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5. The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation

Author

De Roeck, Laurien, van der Weide, Hiska L., Eekers, Daniëlle B.P., Kramer, Miranda C., Alapetite, Claire, Blomstrand, Malin, Burnet, Neil G., Calugaru, Valentin, Coremans, Ida E.M., Di Perri, Dario, Harrabi, Semi, Iannalfi, Alberto, Klaver, Yvonne L.B., Langendijk, Johannes A., Méndez Romero, Alejandra, Paulsen, Frank, Roelofs, Erik, de Ruysscher, Dirk, Timmermann, Beate, Vitek, Pavel, Weber, Damien C., Whitfield, Gillian A., Nyström, Petra Witt, Zindler, Jaap, Troost, Esther G.C., and Lambrecht, Maarten

Published
2022
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6. Current practice in proton therapy delivery in adult cancer patients across Europe

Author

Tambas, Makbule, van der Laan, Hans Paul, Steenbakkers, Roel J.H.M., Doyen, Jerome, Timmermann, Beate, Orlandi, Ester, Hoyer, Morten, Haustermans, Karin, Georg, Petra, Burnet, Neil G, Gregoire, Vincent, Calugaru, Valentin, Troost, Esther G.C., Hoebers, Frank, Calvo, Felipe A., Widder, Joachim, Eberle, Fabian, van Vulpen, Marco, Maingon, Philippe, Skóra, Tomasz, Weber, Damien C., Bergfeldt, Kjell, Kubes, Jiri, and Langendijk, Johannes A.

Published
2022
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9. Update of the EPTN atlas for CT- and MR-based contouring in Neuro-Oncology

Author

Eekers, Daniëlle B.P., Di Perri, Dario, Roelofs, Erik, Postma, Alida, Dijkstra, Jeanette, Ajithkumar, Thankamma, Alapetite, Claire, Blomstrand, Malin, Burnet, Neil G, Calugaru, Valentin, Compter, Inge, Coremans, Ida E.M., Harrabi, Semi, Iannalfi, Alberto, Klaver, Yvonne L.B., Lambrecht, Maarten, Méndez Romero, Alejandra, Paulsen, Frank, Timmermann, Beate, Vitek, Pavel, van der Weide, Hiske L, Whitfield, Gillian A, Nyström, Petra Witt, Zindler, Jaap, de Ruysscher, Dirk, Langendijk, Johannes, Weber, Damien C, and Troost, Esther G.C.

Published
2021
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13. Radiotherapy intensification for atypical and malignant meningiomas: A systematic review

Author

Gaito, Simona, primary, Goyal, Love, additional, Rieu, Romelie, additional, France, Anna, additional, Burnet, Neil G, additional, Barker, Claire, additional, Pan, Shermaine, additional, Colaco, Rovel J, additional, Minniti, Giuseppe, additional, Roncaroli, Federico, additional, Smith, Ed, additional, Aznar, Marianne, additional, and Whitfield, Gillian, additional

Published
2023
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14. Radiation dose constraints for organs at risk in neuro-oncology; the European Particle Therapy Network consensus

Author

Lambrecht, Maarten, Eekers, Daniëlle B.P., Alapetite, Claire, Burnet, Neil G., Calugaru, Valentin, Coremans, Ida E.M., Fossati, Piero, Høyer, Morten, Langendijk, Johannes A., Méndez Romero, Alejandra, Paulsen, Frank, Perpar, Ana, Renard, Laurette, de Ruysscher, Dirk, Timmermann, Beate, Vitek, Pavel, Weber, Damien C., van der Weide, Hiske L., Whitfield, Gillian A., Wiggenraad, Ruud, Roelofs, Erik, Nyström, Petra Witt, and Troost, Esther G.C.

Published
2018
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15. The EPTN consensus-based atlas for CT- and MR-based contouring in neuro-oncology

Author

Eekers, Daniëlle BP, in 't Ven, Lieke, Roelofs, Erik, Postma, Alida, Alapetite, Claire, Burnet, Neil G., Calugaru, Valentin, Compter, Inge, Coremans, Ida E.M., Høyer, Morton, Lambrecht, Maarten, Nyström, Petra Witt, Méndez Romero, Alejandra, Paulsen, Frank, Perpar, Ana, de Ruysscher, Dirk, Renard, Laurette, Timmermann, Beate, Vitek, Pavel, Weber, Damien C., van der Weide, Hiske L., Whitfield, Gillian A., Wiggenraad, Ruud, and Troost, Esther G.C.

Published
2018
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17. Radiotherapy intensification for atypical and malignant meningiomas: A systematic review.

Author

Gaito, Simona, Goyal, Love, Rieu, Romelie, France, Anna, Burnet, Neil G, Barker, Claire, Pan, Shermaine, Colaco, Rovel J, Minniti, Giuseppe, Roncaroli, Federico, Smith, Ed, Aznar, Marianne, and Whitfield, Gillian

Subjects
LITERATURE reviews, RADIOTHERAPY, RANDOMIZED controlled trials, PROGRESSION-free survival, RESEARCH questions
Abstract

Background The outcomes of nonbenign (WHO Grades 2 and 3 [G2, G3]) meningiomas are suboptimal and radiotherapy (RT) dose intensification strategies have been investigated. The purpose of this review is to report on clinical practice and outcomes with particular attention to RT doses and techniques. Methods The PICO criteria (Population, Intervention, Comparison, and Outcomes) were used to frame the research question, directed at outlining the clinical outcomes in patients with G2−3 meningiomas treated with RT. The same search strategy was run in Embase and MEDLINE and, after deduplication, returned 1 807 records. These were manually screened for relevance and 25 were included. Results Tumor outcomes and toxicities are not uniformly reported in the selected studies since different endpoints and time points have been used by different authors. Many risk factors for worse outcomes are described, the most common being suboptimal RT. This includes no or delayed RT, low doses, and older techniques. A positive association between RT dose and progression-free survival (PFS) has been highlighted by analyzing the studies in this review (10/25) that report the same endpoint (5y-PFS). Conclusions This literature review has shown that standard practice RT leads to suboptimal tumor control rates in G2–3 meningiomas, with a significant proportion of disease recurring after a relatively short follow-up. Randomized controlled trials are needed in this setting to define the optimal RT approach. Given the increasing data to suggest a benefit of higher RT doses for high-risk meningiomas, novel RT technologies with highly conformal dose distributions are preferential to achieve optimal target coverage and organs at risk sparing. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

Author

Andreassen, Christian Nicolaj, Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, De Ruysscher, Dirk, Cesaretti, Jamie A., Barnett, Gillian C., Dunning, Alison M., Dorling, Leila, West, Catharine M.L., Burnet, Neil G., Elliott, Rebecca, Coles, Charlotte, Hall, Emma, Fachal, Laura, Vega, Ana, Gómez-Caamaño, Antonio, Talbot, Christopher J., Symonds, R. Paul, De Ruyck, Kim, Thierens, Hubert, Ost, Piet, Chang-Claude, Jenny, Seibold, Petra, Popanda, Odilia, Overgaard, Marie, Dearnaley, David, Sydes, Matthew R., Azria, David, Koch, Christine Anne, Parliament, Matthew, Blackshaw, Michael, Sia, Michael, Fuentes-Raspall, Maria J., Ramon y Cajal, Teresa, Barnadas, Agustin, Vesprini, Danny, Gutiérrez-Enríquez, Sara, Mollà, Meritxell, Díez, Orland, Yarnold, John R., Overgaard, Jens, Bentzen, Søren M., and Alsner, Jan

Published
2016
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22. Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer

Author

Kerns, Sarah L., Dorling, Leila, Fachal, Laura, Bentzen, Søren, Pharoah, Paul D.P., Barnes, Daniel R., Gómez-Caamaño, Antonio, Carballo, Ana M., Dearnaley, David P., Peleteiro, Paula, Gulliford, Sarah L., Hall, Emma, Michailidou, Kyriaki, Carracedo, Ángel, Sia, Michael, Stock, Richard, Stone, Nelson N., Sydes, Matthew R., Tyrer, Jonathan P., Ahmed, Shahana, Parliament, Matthew, Ostrer, Harry, Rosenstein, Barry S., Vega, Ana, Burnet, Neil G., Dunning, Alison M., Barnett, Gillian C., and West, Catharine M.L.

Published
2016
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25. Sub-regional analysis of the parotid glands: model development for predicting late xerostomia with radiomics features in head and neck cancer patients

Author

Berger, Thomas, primary, Noble, David J., additional, Yang, Zhuolin, additional, Shelley, Leila EA., additional, McMullan, Thomas, additional, Bates, Amy, additional, Thomas, Simon, additional, Carruthers, Linda J., additional, Beckett, George, additional, Duffton, Aileen, additional, Paterson, Claire, additional, Jena, Raj, additional, McLaren, Duncan B., additional, Burnet, Neil G., additional, and Nailon, William H., additional

Published
2023
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27. A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity

Author

Barnett, Gillian C., Thompson, Deborah, Fachal, Laura, Kerns, Sarah, Talbot, Chris, Elliott, Rebecca M., Dorling, Leila, Coles, Charlotte E., Dearnaley, David P., Rosenstein, Barry S., Vega, Ana, Symonds, Paul, Yarnold, John, Baynes, Caroline, Michailidou, Kyriaki, Dennis, Joe, Tyrer, Jonathan P., Wilkinson, Jennifer S., Gómez-Caamaño, Antonio, Tanteles, George A., Platte, Radka, Mayes, Rebecca, Conroy, Don, Maranian, Mel, Luccarini, Craig, Gulliford, Sarah L., Sydes, Matthew R., Hall, Emma, Haviland, Joanne, Misra, Vivek, Titley, Jennifer, Bentzen, Søren M., Pharoah, Paul D.P., Burnet, Neil G., Dunning, Alison M., and West, Catharine M.L.

Published
2014
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29. Radiotherapy toxicity

Author

De Ruysscher, Dirk, Niedermann, Gabriele, Burnet, Neil G., Siva, Shankar, Lee, Anne W. M., and Hegi-Johnson, Fiona

Published
2019
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31. No Association Between Polygenic Risk Scores for Cancer and Development of Radiation Therapy Toxicity

Author

Barnett, Gillian C., primary, Kerns, Sarah L., additional, Dorling, Leila, additional, Fachal, Laura, additional, Aguado-Barrera, Miguel E., additional, Martínez-Calvo, Laura, additional, Jandu, Harkeran K., additional, Welsh, Ceilidh, additional, Tyrer, Jonathan, additional, Coles, Charlotte E., additional, Haviland, Joanne S., additional, Parker, Christopher, additional, Gómez-Caamaño, Antonio, additional, Calvo-Crespo, Patricia, additional, Sosa-Fajardo, Paloma, additional, Burnet, Neil G., additional, Summersgill, Holly, additional, Webb, Adam, additional, De Ruysscher, Dirk, additional, Seibold, Petra, additional, Chang-Claude, Jenny, additional, Talbot, Christopher J., additional, Rattay, Tim, additional, Parliament, Matthew, additional, De Ruyck, Kim, additional, Rosenstein, Barry S., additional, Pharoah, Paul D.P., additional, Dunning, Alison M., additional, Vega, Ana, additional, and West, Catharine M.L., additional

Published
2022
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33. No Association Between Polygenic Risk Scores for Cancer and Development of Radiation Therapy Toxicity

Author

Barnett, Gillian C, Kerns, Sarah L, Dorling, Leila, Fachal, Laura, Aguado-Barrera, Miguel E, Martínez-Calvo, Laura, Jandu, Harkeran K, Welsh, Ceilidh, Tyrer, Jonathan, Coles, Charlotte E, Haviland, Joanne S, Parker, Christopher, Gómez-Caamaño, Antonio, Calvo-Crespo, Patricia, Sosa-Fajardo, Paloma, Burnet, Neil G, Summersgill, Holly, Webb, Adam, De Ruysscher, Dirk, Seibold, Petra, Chang-Claude, Jenny, Talbot, Christopher J, Rattay, Tim, Parliament, Matthew, De Ruyck, Kim, Rosenstein, Barry S, Pharoah, Paul DP, Dunning, Alison M, Vega, Ana, West, Catharine ML, RGC and REQUITE Consortia, Coles, Charlotte [0000-0003-4473-8552], Pharoah, Paul [0000-0001-8494-732X], and Apollo - University of Cambridge Repository

Subjects
Male, Biological Products, Risk Factors, Humans, Prostatic Neoplasms, Breast Neoplasms, Genetic Predisposition to Disease, Radiation Injuries, Polymorphism, Single Nucleotide, Genome-Wide Association Study
Abstract

PURPOSE: Our aim was to test whether updated polygenic risk scores (PRS) for susceptibility to cancer affect risk of radiation therapy toxicity. METHODS AND MATERIALS: Analyses included 9,717 patients with breast (n=3,078), prostate (n=5,748) or lung (n=891) cancer from Radiogenomics and REQUITE Consortia cohorts. Patients underwent potentially curative radiation therapy and were assessed prospectively for toxicity. Germline genotyping involved genome-wide single nucleotide polymorphism (SNP) arrays with nontyped SNPs imputed. PRS for each cancer were generated by summing literature-identified cancer susceptibility risk alleles: 352 breast, 136 prostate, and 24 lung. Weighted PRS were generated using log odds ratio (ORs) for cancer susceptibility. Standardized total average toxicity (STAT) scores at 2 and 5 years (breast, prostate) or 6 to 12 months (lung) quantified toxicity. Primary analysis tested late STAT, secondary analyses investigated acute STAT, and individual endpoints and SNPs using multivariable regression. RESULTS: Increasing PRS did not increase risk of late toxicity in patients with breast (OR, 1.000; 95% confidence interval [CI], 0.997-1.002), prostate (OR, 0.99; 95% CI, 0.98-1.00; weighted PRS OR, 0.93; 95% CI, 0.83-1.03), or lung (OR, 0.93; 95% CI, 0.87-1.00; weighted PRS OR, 0.68; 95% CI, 0.45-1.03) cancer. Similar results were seen for acute toxicity. Secondary analyses identified rs138944387 associated with breast pain (OR, 3.05; 95% CI, 1.86-5.01; P = 1.09 × 10-5) and rs17513613 with breast edema (OR, 0.94; 95% CI, 0.92-0.97; P = 1.08 × 10-5). CONCLUSIONS: Patients with increased polygenic predisposition to breast, prostate, or lung cancer can safely undergo radiation therapy with no anticipated excess toxicity risk. Some individual SNPs increase the likelihood of a specific toxicity endpoint, warranting validation in independent cohorts and functional studies to elucidate biologic mechanisms.

Published
2022
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34. Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity

Author

Barnett, Gillian C., Elliott, Rebecca M., Alsner, Jan, Andreassen, Christian N., Abdelhay, Osama, Burnet, Neil G., Chang-Claude, Jenny, Coles, Charlotte E., Gutiérrez-Enríquez, Sara, Fuentes-Raspall, Maria J., Alonso-Muñoz, Maria C., Kerns, Sarah, Raabe, Annette, Symonds, R. Paul, Seibold, Petra, Talbot, Chris J., Wenz, Frederik, Wilkinson, Jennifer, Yarnold, John, Dunning, Alison M., Rosenstein, Barry S., West, Catharine M.L., and Bentzen, Søren M.

Published
2012
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35. Advances in radiotherapy

Author

Ahmad, Saif S, Duke, Simon, Jena, Rajesh, Williams, Michael V, and Burnet, Neil G

Published
2012

37. Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study

Author

Barnett, Gillian C, Coles, Charlotte E, Elliott, Rebecca M, Baynes, Caroline, Luccarini, Craig, Conroy, Don, Wilkinson, Jennifer S, Tyrer, Jonathan, Misra, Vivek, Platte, Radka, Gulliford, Sarah L, Sydes, Matthew R, Hall, Emma, Bentzen, Søren M, Dearnaley, David P, Burnet, Neil G, Pharoah, Paul DP, Dunning, Alison M, and West, Catharine ML

Published
2012
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39. The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation.

Author

UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de radiothérapie oncologique, De Roeck, Laurien, van der Weide, Hiska L, Eekers, Daniëlle B P, Kramer, Miranda C, Alapetite, Claire, Blomstrand, Malin, Burnet, Neil G, Calugaru, Valentin, Coremans, Ida E M, Di Perri, Dario, Harrabi, Semi, Iannalfi, Alberto, Klaver, Yvonne L B, Langendijk, Johannes A, Romero, Alejandra Méndez, Paulsen, Frank, Roelofs, Erik, de Ruysscher, Dirk, Timmermann, Beate, Vitek, Pavel, Weber, Damien C, Whitfield, Gillian A, Nyström, Petra Witt, Zindler, Jaap, Troost, Esther G C, Lambrecht, Maarten, work package 1 of the taskforce “European Particle Therapy Network” of ESTRO, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de radiothérapie oncologique, De Roeck, Laurien, van der Weide, Hiska L, Eekers, Daniëlle B P, Kramer, Miranda C, Alapetite, Claire, Blomstrand, Malin, Burnet, Neil G, Calugaru, Valentin, Coremans, Ida E M, Di Perri, Dario, Harrabi, Semi, Iannalfi, Alberto, Klaver, Yvonne L B, Langendijk, Johannes A, Romero, Alejandra Méndez, Paulsen, Frank, Roelofs, Erik, de Ruysscher, Dirk, Timmermann, Beate, Vitek, Pavel, Weber, Damien C, Whitfield, Gillian A, Nyström, Petra Witt, Zindler, Jaap, Troost, Esther G C, Lambrecht, Maarten, and work package 1 of the taskforce “European Particle Therapy Network” of ESTRO

Abstract

Treatment-related toxicity after irradiation of brain tumours has been underreported in the literature. Furthermore, there is considerable heterogeneity on how and when toxicity is evaluated. The aim of this European Particle Network (EPTN) collaborative project is to develop recommendations for uniform follow-up and toxicity scoring of adult brain tumour patients treated with radiotherapy. A Delphi method-based consensus was reached among 24 international radiation-oncology experts in the field of neuro-oncology concerning the toxicity endpoints, evaluation methods and time points. In this paper, we present a basic framework for consistent toxicity scoring and follow-up, using multiple levels of recommendation. Level I includes all recommendations that are considered minimum of care, whereas level II and III are optional evaluations in the advanced clinical or research setting, respectively. Per outcome domain, the clinical endpoints and evaluation methods per level are listed. Where relevant, the organ at risk threshold doses for recommended referral to specific organ specialists are defined. These consensus-based recommendations for follow-up will enable the collection of uniform toxicity data of brain tumour patients treated with radiotherapy. With adoptation of this standard, collaboration will be facilitated and we can further propel the research field of radiation-induced toxicities relevant for these patients. An online tool to implement this guideline in clinical practice is provided at www.cancerdata.org.

Published
2022

42. The suitability of micronuclei as markers of relative biological effect

Author

Heaven, Charlotte J, primary, Wanstall, Hannah C, additional, Henthorn, Nicholas T, additional, Warmenhoven, John-William, additional, Ingram, Samuel P, additional, Chadwick, Amy L, additional, Santina, Elham, additional, Honeychurch, Jamie, additional, Schmidt, Christine K, additional, Kirkby, Karen J, additional, Kirkby, Norman F, additional, Burnet, Neil G, additional, and Merchant, Michael J, additional

Published
2022
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45. Update of the EPTN atlas for CT- and MR-based contouring in Neuro-Oncology.

Author

UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de radiothérapie oncologique, Eekers, Daniëlle B P, Di Perri, Dario, Roelofs, Erik, Postma, Alida, Dijkstra, Jeanette, Ajithkumar, Thankamma, Alapetite, Claire, Blomstrand, Malin, Burnet, Neil G, Calugaru, Valentin, Compter, Inge, Coremans, Ida E M, Harrabi, Semi, Iannalfi, Alberto, Klaver, Yvonne L B, Lambrecht, Maarten, Romero, Alejandra Méndez, Paulsen, Frank, Timmermann, Beate, Vitek, Pavel, van der Weide, Hiske L, Whitfield, Gillian A, Nyström, Petra Witt, Zindler, Jaap, de Ruysscher, Dirk, Langendijk, Johannes, Weber, Damien C, Troost, Esther G C, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de radiothérapie oncologique, Eekers, Daniëlle B P, Di Perri, Dario, Roelofs, Erik, Postma, Alida, Dijkstra, Jeanette, Ajithkumar, Thankamma, Alapetite, Claire, Blomstrand, Malin, Burnet, Neil G, Calugaru, Valentin, Compter, Inge, Coremans, Ida E M, Harrabi, Semi, Iannalfi, Alberto, Klaver, Yvonne L B, Lambrecht, Maarten, Romero, Alejandra Méndez, Paulsen, Frank, Timmermann, Beate, Vitek, Pavel, van der Weide, Hiske L, Whitfield, Gillian A, Nyström, Petra Witt, Zindler, Jaap, de Ruysscher, Dirk, Langendijk, Johannes, Weber, Damien C, and Troost, Esther G C

Abstract

To update the digital online atlas for organs at risk (OARs) delineation in neuro-oncology based on high-quality computed tomography (CT) and magnetic resonance (MR) imaging with new OARs. In this planned update of the neurological contouring atlas published in 2018, ten new clinically relevant OARs were included, after thorough discussion between experienced neuro-radiation oncologists (RTOs) representing 30 European radiotherapy-oncology institutes. Inclusion was based on daily practice and research requirements. Consensus was reached for the delineation after critical review. Contouring was performed on registered CT with intravenous (IV) contrast (soft tissue & bone window setting) and 3 Tesla (T) MRI (T1 with gadolinium & T2 FLAIR) images of one patient (1 mm slices). For illustration purposes, delineation on a 7 T MRI without IV contrast from a healthy volunteer was added. OARs were delineated by three experienced RTOs and a neuroradiologist based on the relevant literature. The presented update of the neurological contouring atlas was reviewed and approved by 28 experts in the field. The atlas is available online and includes in total 25 OARs relevant to neuro-oncology, contoured on CT and MRI T1 and FLAIR (3 T & 7 T). Three-dimensional (3D) rendered films are also available online. In order to further decrease inter- and intra-observer OAR delineation variability in the field of neuro-oncology, we propose the use of this contouring atlas in photon and particle therapy, in clinical practice and in the research setting. The updated atlas is freely available on www.cancerdata.org.

Published
2021

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