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7 results on '"Burns, Suzanne S."'

1. The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation

Author

Kosti, Adam, de Araujo, Patricia Rosa, Li, Wei-Qing, Guardia, Gabriela D. A., Chiou, Jennifer, Yi, Caihong, Ray, Debashish, Meliso, Fabiana, Li, Yi-Ming, Delambre, Talia, Qiao, Mei, Burns, Suzanne S., Lorbeer, Franziska K., Georgi, Fanny, Flosbach, Markus, Klinnert, Sarah, Jenseit, Anne, Lei, Xiufen, Sandoval, Carolina Romero, Ha, Kevin, Zheng, Hong, Pandey, Renu, Gruslova, Aleksandra, Gupta, Yogesh K., Brenner, Andrew, Kokovay, Erzsebet, Hughes, Timothy R., Morris, Quaid D., Galante, Pedro A. F., Tiziani, Stefano, and Penalva, Luiz O. F.

Published
2020
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2. Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes

Author

Baroni, Mirella, Yi, Caihong, Choudhary, Saket, Lei, Xiufen, Kosti, Adam, Grieshober, Denise, Velasco, Mitzli, Qiao, Mei, Burns, Suzanne S., Araujo, Patricia R., DeLambre, Talia, Son, Mi Young, Plateroti, Michelina, Ferreira, Marco A. R., Hasty, Paul, Penalva, Luiz O. F., Baroni, Mirella, Yi, Caihong, Choudhary, Saket, Lei, Xiufen, Kosti, Adam, Grieshober, Denise, Velasco, Mitzli, Qiao, Mei, Burns, Suzanne S., Araujo, Patricia R., DeLambre, Talia, Son, Mi Young, Plateroti, Michelina, Ferreira, Marco A. R., Hasty, Paul, and Penalva, Luiz O. F.

Abstract

RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in their levels are often observed in tumors with numerous oncogenic RBPs identified in recent years. Musashi1 (Msi1) is an RBP and stem cell gene that controls the balance between self-renewal and differentiation. High Msi1 levels have been observed in multiple tumors including glioblastoma and are often associated with poor patient outcomes and tumor growth. A comprehensive genomic analysis identified a network of cell cycle/division and DNA replication genes and established these processes as Msi1’s core regulatory functions in glioblastoma. Msi1 controls this gene network via two mechanisms: direct interaction and indirect regulation mediated by the transcription factors E2F2 and E2F8. Moreover, glioblastoma lines with Msi1 knockout (KO) displayed increased sensitivity to cell cycle and DNA replication inhibitors. Our results suggest that a drug combination strategy (Msi1 + cell cycle/DNA replication inhibitors) could be a viable route to treat glioblastoma.

Published
2021
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3. Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes

Author

Statistics, Baroni, Mirella, Yi, Caihong, Choudhary, Saket, Lei, Xiufen, Kosti, Adam, Grieshober, Denise, Velasco, Mitzli, Qiao, Mei, Burns, Suzanne S., Araujo, Patricia R., DeLambre, Talia, Son, Mi Young, Plateroti, Michelina, Ferreira, Marco A. R., Hasty, Paul, Penalva, Luiz O. F., Statistics, Baroni, Mirella, Yi, Caihong, Choudhary, Saket, Lei, Xiufen, Kosti, Adam, Grieshober, Denise, Velasco, Mitzli, Qiao, Mei, Burns, Suzanne S., Araujo, Patricia R., DeLambre, Talia, Son, Mi Young, Plateroti, Michelina, Ferreira, Marco A. R., Hasty, Paul, and Penalva, Luiz O. F.

Abstract

RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in their levels are often observed in tumors with numerous oncogenic RBPs identified in recent years. Musashi1 (Msi1) is an RBP and stem cell gene that controls the balance between self-renewal and differentiation. High Msi1 levels have been observed in multiple tumors including glioblastoma and are often associated with poor patient outcomes and tumor growth. A comprehensive genomic analysis identified a network of cell cycle/division and DNA replication genes and established these processes as Msi1’s core regulatory functions in glioblastoma. Msi1 controls this gene network via two mechanisms: direct interaction and indirect regulation mediated by the transcription factors E2F2 and E2F8. Moreover, glioblastoma lines with Msi1 knockout (KO) displayed increased sensitivity to cell cycle and DNA replication inhibitors. Our results suggest that a drug combination strategy (Msi1 + cell cycle/DNA replication inhibitors) could be a viable route to treat glioblastoma.

Published
2021

4. Additional file 1 of The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation

Author

Kosti, Adam, Araujo, Patricia Rosa De, Li, Wei-Qing, Guardia, Gabriela D. A., Chiou, Jennifer, Caihong Yi, Debashish Ray, Meliso, Fabiana, Li, Yi-Ming, Delambre, Talia, Qiao, Mei, Burns, Suzanne S., Lorbeer, Franziska K., Georgi, Fanny, Flosbach, Markus, Klinnert, Sarah, Jenseit, Anne, Xiufen Lei, Sandoval, Carolina Romero, Ha, Kevin, Zheng, Hong, Pandey, Renu, Gruslova, Aleksandra, Gupta, Yogesh K., Brenner, Andrew, Erzsebet Kokovay, Hughes, Timothy R., Quaid D. Morris, Galante, Pedro A. F., Tiziani, Stefano, and Penalva, Luiz O. F.

Abstract

Additional file 1: Supplementary Figures and Legends (Figs. S1-S9). Contains compiled supplementary figures and legends referenced in the main text.

Published
2020
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5. Additional file 4 of The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation

Author

Kosti, Adam, Araujo, Patricia Rosa De, Li, Wei-Qing, Guardia, Gabriela D. A., Chiou, Jennifer, Caihong Yi, Debashish Ray, Meliso, Fabiana, Li, Yi-Ming, Delambre, Talia, Qiao, Mei, Burns, Suzanne S., Lorbeer, Franziska K., Georgi, Fanny, Flosbach, Markus, Klinnert, Sarah, Jenseit, Anne, Xiufen Lei, Sandoval, Carolina Romero, Ha, Kevin, Zheng, Hong, Pandey, Renu, Gruslova, Aleksandra, Gupta, Yogesh K., Brenner, Andrew, Erzsebet Kokovay, Hughes, Timothy R., Quaid D. Morris, Galante, Pedro A. F., Tiziani, Stefano, and Penalva, Luiz O. F.

Abstract

Additional file 4: Table S3. Clinicopathological characteristics of 177 glioma patients from Shanghai Changzheng Hospital, and results of SERBP1 immunostaining.

Published
2020
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6. Additional file 2 of The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation

Author

Kosti, Adam, Araujo, Patricia Rosa De, Li, Wei-Qing, Guardia, Gabriela D. A., Chiou, Jennifer, Caihong Yi, Debashish Ray, Meliso, Fabiana, Li, Yi-Ming, Delambre, Talia, Qiao, Mei, Burns, Suzanne S., Lorbeer, Franziska K., Georgi, Fanny, Flosbach, Markus, Klinnert, Sarah, Jenseit, Anne, Xiufen Lei, Sandoval, Carolina Romero, Ha, Kevin, Zheng, Hong, Pandey, Renu, Gruslova, Aleksandra, Gupta, Yogesh K., Brenner, Andrew, Erzsebet Kokovay, Hughes, Timothy R., Quaid D. Morris, Galante, Pedro A. F., Tiziani, Stefano, and Penalva, Luiz O. F.

Abstract

Additional file 2: Table S1. SERBP1 expression in glioma (TCGA) and brain/cortex (GTEx).

Published
2020
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7. Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes.

Author

Baroni M, Yi C, Choudhary S, Lei X, Kosti A, Grieshober D, Velasco M, Qiao M, Burns SS, Araujo PR, DeLambre T, Son MY, Plateroti M, Ferreira MAR, Hasty P, and Penalva LOF

Abstract

RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in their levels are often observed in tumors with numerous oncogenic RBPs identified in recent years. Musashi1 (Msi1) is an RBP and stem cell gene that controls the balance between self-renewal and differentiation. High Msi1 levels have been observed in multiple tumors including glioblastoma and are often associated with poor patient outcomes and tumor growth. A comprehensive genomic analysis identified a network of cell cycle/division and DNA replication genes and established these processes as Msi1's core regulatory functions in glioblastoma. Msi1 controls this gene network via two mechanisms: direct interaction and indirect regulation mediated by the transcription factors E2F2 and E2F8. Moreover, glioblastoma lines with Msi1 knockout (KO) displayed increased sensitivity to cell cycle and DNA replication inhibitors. Our results suggest that a drug combination strategy (Msi1 + cell cycle/DNA replication inhibitors) could be a viable route to treat glioblastoma.

Published
2021
Full Text
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