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25 results on '"Burny, Claire"'

1. Epigenenomic and transcriptomic characterization of NPM1-mutated CN-AML subtypes

Author

NGuyen, Lia, primary, Tellez Quijorna, Clara, additional, Vernerey, Julien, additional, Garciaz, Sylvain, additional, Carbuccia, Nadine, additional, Guille, Arnaud, additional, Burny, Claire, additional, Poplineau, Mathilde, additional, Murati, Anne, additional, Hospital, Marie Anne, additional, Vey, Norbert, additional, Birnbaum, Daniel, additional, and DUPREZ, Estelle, additional

Published
2024
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2. Acute multi-level response to defective de novo chromatin assembly in S-phase

Author

Dreyer, Jan, primary, Ricci, Giulia, additional, van den Berg, Jeroen, additional, Bhardwaj, Vivek, additional, Funk, Janina, additional, Armstrong, Claire, additional, van Batenburg, Vincent, additional, Sine, Chance, additional, Vaninsberghe, Michael A., additional, Marsman, Richard, additional, Mandemaker, Imke K., additional, di Sanzo, Simone, additional, Costantini, Juliette, additional, Manzo, Stefano, additional, Biran, Alva, additional, Burny, Claire, additional, Voelker-Albert, Moritz, additional, Groth, Anja, additional, Spencer, Sabrina L, additional, van Oudenaarden, Alexander, additional, and Mattiroli, Francesca, additional

Published
2024
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7. Highly Parallel Genomic Selection Response in Replicated Drosophila melanogaster Populations with Reduced Genetic Variation

Author

Schlötterer Christian, Nolte Viola, Burny Claire, and Dolezal Marlies

Subjects
AcademicSubjects/SCI01140, Multifactorial Inheritance, Genome, Insect, inbred strains, evolve and resequence, Biology, Genome, Genetic variation, Genetics, Animals, experimental evolution, Selection, Genetic, Ecology, Evolution, Behavior and Systematics, Selection (genetic algorithm), parallelism, Experimental evolution, Selection coefficient, AcademicSubjects/SCI01130, Genetic Variation, Genomics, biology.organism_classification, polygenic trait, Drosophila melanogaster, Evolutionary biology, Genetic redundancy, Adaptation, Research Article
Abstract

Many adaptive traits are polygenic and frequently more loci contributing to the phenotype than needed are segregating in populations to express a phenotypic optimum. Experimental evolution provides a powerful approach to study polygenic adaptation using replicated populations adapting to a new controlled environment. Since genetic redundancy often results in non-parallel selection responses among replicates, we propose a modified Evolve and Resequencing (E&R) design that maximizes the similarity among replicates. Rather than starting from many founders, we only use two inbred Drosophila melanogaster strains and expose them to a very extreme, hot temperature environment (29°C). After 20 generations, we detect many genomic regions with a strong, highly parallel selection response in 10 evolved replicates. The X chromosome has a more pronounced selection response than the autosomes, which may be attributed to dominance effects. Furthermore, we find that the median selection coefficient for all chromosomes is higher in our two-genotype experiment than in classic E&R studies. Since two random genomes harbor sufficient variation for adaptive responses, we propose that this approach is particularly well-suited for the analysis of polygenic adaptation.

Published
2021

17. Males as somatic investment in a parthenogenetic nematode

Author

Grosmaire, Manon, primary, Launay, Caroline, additional, Siegwald, Marion, additional, Brugière, Thibault, additional, Estrada-Virrueta, Lilia, additional, Berger, Duncan, additional, Burny, Claire, additional, Modolo, Laurent, additional, Blaxter, Mark, additional, Meister, Peter, additional, Félix, Marie-Anne, additional, Gouyon, Pierre-Henri, additional, and Delattre, Marie, additional

Published
2019
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18. Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription

Author

Hocquet, Clémence, primary, Robellet, Xavier, additional, Modolo, Laurent, additional, Sun, Xi-Ming, additional, Burny, Claire, additional, Cuylen-Haering, Sara, additional, Toselli, Esther, additional, Clauder-Münster, Sandra, additional, Steinmetz, Lars, additional, Haering, Christian H, additional, Marguerat, Samuel, additional, and Bernard, Pascal, additional

Published
2018
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19. Author response: Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription

Author

Hocquet, Clémence, primary, Robellet, Xavier, additional, Modolo, Laurent, additional, Sun, Xi-Ming, additional, Burny, Claire, additional, Cuylen-Haering, Sara, additional, Toselli, Esther, additional, Clauder-Münster, Sandra, additional, Steinmetz, Lars, additional, Haering, Christian H, additional, Marguerat, Samuel, additional, and Bernard, Pascal, additional

Published
2018
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24. Acute multi-level response to defective de novo chromatin assembly in S-phase.

Author

Dreyer J, Ricci G, van den Berg J, Bhardwaj V, Funk J, Armstrong C, van Batenburg V, Sine C, VanInsberghe MA, Marsman R, Mandemaker IK, di Sanzo S, Costantini J, Manzo SG, Biran A, Burny C, Völker-Albert M, Groth A, Spencer SL, van Oudenaarden A, and Mattiroli F

Abstract

Long-term perturbation of de novo chromatin assembly during DNA replication has profound effects on epigenome maintenance and cell fate. The early mechanistic origin of these defects is unknown. Here, we combine acute degradation of Chromatin Assembly Factor 1 (CAF-1), a key player in de novo chromatin assembly, with single-cell genomics, quantitative proteomics, and live-microscopy to uncover these initiating mechanisms in human cells. CAF-1 loss immediately slows down DNA replication speed and renders nascent DNA hyperaccessible. A rapid cellular response, distinct from canonical DNA damage signaling, is triggered and lowers histone mRNAs. As a result, histone variants usage and their modifications are altered, limiting transcriptional fidelity and delaying chromatin maturation within a single S-phase. This multi-level response induces a cell-cycle arrest after mitosis. Our work reveals the immediate consequences of defective de novo chromatin assembly during DNA replication, explaining how at later times the epigenome and cell fate can be altered.

Published
2024
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25. Genome-wide selection signatures reveal widespread synergistic effects of two different stressors in Drosophila melanogaster .

Author

Burny C, Nolte V, Dolezal M, and Schlötterer C

Subjects
Animals, Genome, Gene Frequency, Adaptation, Physiological genetics, Drosophila melanogaster genetics, Selection, Genetic
Abstract

Experimental evolution combined with whole-genome sequencing (evolve and resequence (E&R)) is a powerful approach to study the adaptive architecture of selected traits. Nevertheless, so far the focus has been on the selective response triggered by a single stressor. Building on the highly parallel selection response of founder populations with reduced variation, we evaluated how the presence of a second stressor affects the genomic selection response. After 20 generations of adaptation to laboratory conditions at either 18°C or 29°C, strong genome-wide selection signatures were observed. Only 38% of the selection signatures can be attributed to laboratory adaptation (no difference between temperature regimes). The remaining selection responses are either caused by temperature-specific effects, or reflect the joint effects of temperature and laboratory adaptation (same direction, but the magnitude differs between temperatures). The allele frequency changes resulting from the combined effects of temperature and laboratory adaptation were more extreme in the hot environment for 83% of the affected genomic regions-indicating widespread synergistic effects of the two stressors. We conclude that E&R with reduced genetic variation is a powerful approach to study genome-wide fitness consequences driven by the combined effects of multiple environmental factors.

Published
2022
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