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4. Plasticized 3D-Printed Polymer Electrolytes for Lithium-Ion Batteries

Author

Vinegrad, Adi, primary, Ragones, Heftsi, additional, Jayakody, Nishani, additional, Ardel, Gilat, additional, Goor, Meital, additional, Kamir, Yossi, additional, Dorfman, Moty Marcos, additional, Gladkikh, Alexander, additional, Burstein, Larisa, additional, Horowitz, Yonatan, additional, Greenbaum, Steve, additional, and Golodnitsky, Diana, additional

Published
2021
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7. Understanding the Role of Alumina (Al 2 O 3 ), Pentalithium Aluminate (Li 5 AlO 4 ), and Pentasodium Aluminate (Na 5 AlO 4 ) Coatings on the Li and Mn‐Rich NCM Cathode Material 0.33Li 2 MnO 3 ·0.67Li(Ni 0.4 Co 0.2 Mn 0.4 )O 2 for Enhanced Electrochemical Performance

Author

Maiti, Sandipan, primary, Sclar, Hadar, additional, Sharma, Rosy, additional, Vishkin, Noam, additional, Fayena‐Greenstein, Miryam, additional, Grinblat, Judith, additional, Talianker, Michael, additional, Burstein, Larisa, additional, Solomatin, Nickolay, additional, Tiurin, Ortal, additional, Ein‐Eli, Yair, additional, Noked, Malachi, additional, Markovsky, Boris, additional, and Aurbach, Doron, additional

Published
2020
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9. Enhancement of Electrochemical Performance of Lithium and Manganese-Rich Cathode Materials via Thermal Treatment with SO2

Author

Sclar, Hadar, primary, Sicklinger, Johannes, additional, Erickson, Evan M., additional, Maiti, Sandipan, additional, Grinblat, Judith, additional, Talianker, Michael, additional, Amalraj Susai, Francis, additional, Burstein, Larisa, additional, Beyer, Hans, additional, Hartmann, Louis, additional, Avruschenko, Gregory, additional, Gasteiger, Hubert A., additional, Markovsky, Boris, additional, and Aurbach, Doron, additional

Published
2020
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10. Stabilized Behavior of LiNi0.85Co0.10Mn0.05O2 Cathode Materials Induced by Their Treatment with SO2

Author

Susai, Francis Amalraj, primary, Sclar, Hadar, additional, Maiti, Sandipan, additional, Burstein, Larisa, additional, Perkal, Ortal, additional, Grinblat, Judith, additional, Talianker, Michael, additional, Ruthstein, Sharon, additional, Erk, Christoph, additional, Hartmann, Pascal, additional, Markovsky, Boris, additional, and Aurbach, Doron, additional

Published
2020
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11. Light-Controlled Selective Collection-and-Release of Biomolecules by an On-Chip Nanostructured Device

Author

Borberg, Ella, primary, Zverzhinetsky, Marina, additional, Krivitsky, Adva, additional, Kosloff, Alon, additional, Heifler, Omri, additional, Degabli, Gal, additional, Soroka, Hagit Peretz, additional, Fainaro, Ronit Satchi, additional, Burstein, Larisa, additional, Reuveni, Shlomi, additional, Diamant, Haim, additional, Krivitsky, Vadim, additional, and Patolsky, Fernando, additional

Published
2019
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12. Disiloxane with nitrile end groups as Co-solvent for electrolytes in lithium sulfur batteries – A feasible approach to replace LiNO3

Author

Mukra, Tzach, primary, Horowitz, Yonatan, additional, Shekhtman, Inna, additional, Goor, Meital, additional, Drvarič Talian, Sara, additional, Burstein, Larisa, additional, Kasnatscheew, Johannes, additional, Meister, Paul, additional, Grünebaum, Mariano, additional, Winter, Martin, additional, Wiemhöfer, Hans-Dieter, additional, Golodnitsky, Diana, additional, and Peled, Emanuel, additional

Published
2019
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13. Improving Performance of LiNi0.8Co0.1Mn0.1O2 Cathode Materials for Lithium-Ion Batteries by Doping with Molybdenum-Ions: Theoretical and Experimental Studies

Author

Susai, Francis Amalraj, primary, Kovacheva, Daniela, additional, Chakraborty, Arup, additional, Kravchuk, Tatyana, additional, Ravikumar, R., additional, Talianker, Michael, additional, Grinblat, Judith, additional, Burstein, Larisa, additional, Kauffmann, Yaron, additional, Major, Dan Thomas, additional, Markovsky, Boris, additional, and Aurbach, Doron, additional

Published
2019
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15. Understanding the Role of Alumina (Al2O3), Pentalithium Aluminate (Li5AlO4), and Pentasodium Aluminate (Na5AlO4) Coatings on the Li and Mn‐Rich NCM Cathode Material 0.33Li2MnO3·0.67Li(Ni0.4Co0.2Mn0.4)O2 for Enhanced Electrochemical Performance

Author

Maiti, Sandipan, Sclar, Hadar, Sharma, Rosy, Vishkin, Noam, Fayena‐Greenstein, Miryam, Grinblat, Judith, Talianker, Michael, Burstein, Larisa, Solomatin, Nickolay, Tiurin, Ortal, Ein‐Eli, Yair, Noked, Malachi, Markovsky, Boris, and Aurbach, Doron

Subjects
ATOMIC layer deposition, CATHODES, ALUMINATES, ALUMINUM-lithium alloys, ELECTROLYTE solutions, ELECTROCHEMICAL electrodes, ALUMINUM oxide, TRANSITION metals
Abstract

The active role of alumina, pentalithium aluminate (Li5AlO4, Li‐aluminate), and pentasodium aluminate (Na5AlO4, Na‐aluminate) as the surface protection coatings produced via atomic layer deposition on Li and Mn‐rich NCM cathode materials 0.33Li2MnO3·0.67LiNi0.4Co0.2Mn0.4O2 is discussed. A notable improvement in the electrochemical behavior of the coated cathodes has been found while tested in Li‐coin cells at 30 °C. Though all the coated cathodes demonstrate enhanced electrochemical cycling and rate performances, Na‐aluminate coated cathodes exhibit exemplary behavior. Prolonged cycling and rate capability testing demonstrate that after more than 400 cycles at 1 C rate, the uncoated cathode delivers only 63 mAh g−1, while those with alumina, Li‐aluminate, and Na‐aluminate coatings exhibit approximately two times higher specific capacities. The coated cathodes display steady average discharge potential and lower evolution of the voltage hysteresis during prolonged cycling compared to the uncoated cathode. Importantly, Na‐aluminate coated cathode shows a lowering in gases (O2, CO2, H2, etc.) evolution. Post‐cycling analysis of the electrodes demonstrates higher morphological integrity of the coated cathode materials and lower transition metals dissolution from them. The coatings mitigate undesirable side reactions between the electrodes and the electrolyte solution in the cells. [ABSTRACT FROM AUTHOR]

Published
2021
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16. Light-Controlled Selective Collection-and-Release of Biomolecules by an On-Chip Nanostructured Device

Author

Borberg, Ella, Zverzhinetsky, Marina, Krivitsky, Adva, Kosloff, Alon, Heifler, Omri, Degabli, Gal, Soroka, Hagit Peretz, Fainaro, Ronit Satchi, Burstein, Larisa, Reuveni, Shlomi, Diamant, Haim, Krivitsky, Vadim, and Patolsky, Fernando

Abstract

The analysis of biosamples, e.g., blood, is a ubiquitous task of proteomics, genomics, and biosensing fields; yet, it still faces multiple challenges, one of the greatest being the selective separation and detection of target proteins from these complex biosamples. Here, we demonstrate the development of an on-chip light-triggered reusable nanostructured selective and quantitative protein separation and preconcentration platform for the direct analysis of complex biosamples. The on-chip selective separation of required protein analytes from raw biosamples is performed using antibody–photoacid-modified Si nanopillars vertical arrays (SiNPs) of ultralarge binding surface area and enormously high binding affinity, followed by the light-controlled rapid release of the tightly bound target proteins in a controlled liquid media. Two important experimental observations are presented: (1) the first demonstration on the control of biological reaction binding affinity by the nanostructuring of the capturing surface, leading to highly efficient protein collection capabilities, and (2) the light-triggered switching of the highly sticky binding surfaces into highly reflective nonbinding surfaces, leading to the rapid and quantitative release of the originally tightly bound protein species. Both of these two novel behaviors were theoretically and experimentally investigated. Importantly, this is the first demonstration of a three-dimensional (3D) SiNPs on-chip filter with ultralarge binding surface area and reversible light-controlled quantitative release of adsorbed biomolecules for direct purification of blood samples, able to selectively collect and separate specific low abundant proteins, while easily removing unwanted blood components (proteins, cells) and achieving desalting results, without the requirement of time-consuming centrifugation steps, the use of desalting membranes, or affinity columns.

Published
2024
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19. Understanding the Role of Minor Molybdenum Doping in LiNi0.5Co0.2Mn0.3O2 Electrodes: from Structural and Surface Analyses and Theoretical Modeling to Practical Electrochemical Cells

Author

Breuer, Ortal, primary, Chakraborty, Arup, additional, Liu, Jing, additional, Kravchuk, Tatyana, additional, Burstein, Larisa, additional, Grinblat, Judith, additional, Kauffman, Yaron, additional, Gladkih, Alexandr, additional, Nayak, Prasant, additional, Tsubery, Merav, additional, Frenkel, Anatoly I., additional, Talianker, Michael, additional, Major, Dan T., additional, Markovsky, Boris, additional, and Aurbach, Doron, additional

Published
2018
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21. From Surface ZrO2 Coating to Bulk Zr Doping by High Temperature Annealing of Nickel-Rich Lithiated Oxides and Their Enhanced Electrochemical Performance in Lithium Ion Batteries

Author

Schipper, Florian, primary, Bouzaglo, Hana, additional, Dixit, Mudit, additional, Erickson, Evan M., additional, Weigel, Tina, additional, Talianker, Michael, additional, Grinblat, Judith, additional, Burstein, Larisa, additional, Schmidt, Michael, additional, Lampert, Jordan, additional, Erk, Christoph, additional, Markovsky, Boris, additional, Major, Dan Thomas, additional, and Aurbach, Doron, additional

Published
2017
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22. High‐Temperature Treatment of Li‐Rich Cathode Materials with Ammonia: Improved Capacity and Mean Voltage Stability during Cycling

Author

Erickson, Evan M., primary, Sclar, Hadar, additional, Schipper, Florian, additional, Liu, Jing, additional, Tian, Ruiyuan, additional, Ghanty, Chandan, additional, Burstein, Larisa, additional, Leifer, Nicole, additional, Grinblat, Judith, additional, Talianker, Michael, additional, Shin, Ji‐Yong, additional, Lampert, Jordan K., additional, Markovsky, Boris, additional, Frenkel, Anatoly I., additional, and Aurbach, Doron, additional

Published
2017
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23. Modification of Li- and Mn-Rich Cathode Materials viaFormation of the Rock-Salt and Spinel Surface Layers for Steady and High-Rate Electrochemical Performances

Author

Maiti, Sandipan, Sclar, Hadar, Rosy, Grinblat, Judith, Talianker, Michael, Burstein, Larisa, Noked, Malachi, Markovsky, Boris, and Aurbach, Doron

Abstract

We demonstrate a novel surface modification of Li- and Mn-rich cathode materials 0.33Li2MnO3·0.67LiNi0.4Co0.2Mn0.4O2for lithium-ion batteries (high-energy Ni–Co–Mn oxides, HE-NCM) viatheir heat treatment with trimesic acid (TA) or terephthalic acid at 600 °C under argon. We established the optimal regimes of the treatment—the amounts of HE-NCM, acid, temperature, and time—resulting in a significant improvement of the electrochemical behavior of cathodes in Li cells. It was shown that upon treatment, some lithium is leached out from the surface, leading to the formation of a surface layer comprising rock-salt-like phase Li0.4Ni1.6O2. The analysis of the structural and surface studies by X-ray diffraction, transmission electron microscopy, and X-ray photoelectron spectroscopy confirmed the formation of the above surface layer. We discuss the possible reactions of HE-NCM with the acids and the mechanism of the formation of the new phases, Li0.4Ni1.6O2and spinel. The electrochemical characterizations were performed by testing the materials versusLi anodes at 30 °C. Importantly, the electrochemical results disclose significantly improved cycling stability (much lower capacity fading) and high-rate performance for the treated materials compared to the untreated ones. We established a lower evolution of the voltage hysteresis with cycling for the treated cathodes compared to that for the untreated ones. Thermal studies by differential scanning calorimetry also demonstrated lower (by ∼32%) total heat released in the reactions of the materials treated with fluoroethylene carbonate (FEC)−dimethyl carbonate (DEC)/LiPF6electrolyte solutions, thus implying their significant surface stabilization because of the surface treatment. It was established by a postmortem analysis after 400 cycles that a lower amount of transition-metal cations dissolved (especially Ni) and a reduced number of surface cracks were formed for the 2 wt % TA-treated HE-NCMs compared to the untreated ones. We consider the proposed method of surface modification as a simple, cheap, and scalable approach to achieve a steady and superior electrochemical performance of HE-NCM cathodes.

Published
2020
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28. From Surface ZrO2 Coating to Bulk Zr Doping by High Temperature Annealing of Nickel‐Rich Lithiated Oxides and Their Enhanced Electrochemical Performance in Lithium Ion Batteries.

Author

Schipper, Florian, Bouzaglo, Hana, Dixit, Mudit, Erickson, Evan M., Weigel, Tina, Talianker, Michael, Grinblat, Judith, Burstein, Larisa, Schmidt, Michael, Lampert, Jordan, Erk, Christoph, Markovsky, Boris, Major, Dan Thomas, and Aurbach, Doron

Subjects
LITHIUM-ion batteries, ZIRCONIUM oxide, METAL coating, DOPING agents (Chemistry), ANNEALING of metals, NICKEL oxides, ELECTROCHEMICAL sensors
Abstract

Abstract: One of the major hurdles of Ni‐rich cathode materials Li1+x(NixCozMnz)wO2, y > 0.5 for lithium‐ion batteries is their low cycling stability especially for compositions with Ni ≥ 60%, which suffer from severe capacity fading and impedance increase during cycling at elevated temperatures (e.g., 45 °C). Two promising surface and structural modifications of these materials to alleviate the above drawback are (1) coatings by electrochemically inert inorganic compounds (e.g., ZrO2) or (2) lattice doping by cations like Zr4+, Al3+, Mg2+, etc. This paper demonstrates the enhanced electrochemical behavior of Ni‐rich material LiNi0.8Co0.1Mn0.1O2 (NCM811) coated with a thin ZrO2 layer. The coating is produced by an easy and scalable wet chemical approach followed by annealing the material at ≥700 °C under oxygen that results in Zr doping. It is established that some ZrO2 remains even after annealing at ≥800 °C as a surface layer on NCM811. The main finding of this work is the enhanced cycling stability and lower impedance of the coated/doped NCM811 that can be attributed to a synergetic effect of the ZrO2 coating in combination with a zirconium doping. [ABSTRACT FROM AUTHOR]

Published
2018
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29. Understanding the Role of Minor Molybdenum Doping in LiNi0.5Co0.2Mn0.3O2Electrodes: from Structural and Surface Analyses and Theoretical Modeling to Practical Electrochemical Cells

Author

Breuer, Ortal, Chakraborty, Arup, Liu, Jing, Kravchuk, Tatyana, Burstein, Larisa, Grinblat, Judith, Kauffman, Yaron, Gladkih, Alexandr, Nayak, Prasant, Tsubery, Merav, Frenkel, Anatoly I., Talianker, Michael, Major, Dan T., Markovsky, Boris, and Aurbach, Doron

Abstract

Doping LiNi0.5Co0.2Mn0.3O2(NCM523) cathode material by small amount of Mo6+ions, around 1 mol %, affects pronouncedly its structure, surface properties, and electronic and electrochemical behavior. Cathodes comprising Mo6+-doped NCM523 exhibited in Li cells higher specific capacities, higher rate capabilities, lower capacity fading, and lower charge-transfer resistance that relates to a more stable electrode/solution interface due to doping. This, in turn, is ascribed to the fact that the Mo6+ions tend to concentrate more at the surface, as a result of a synthesis that always includes a necessary calcination, high-temperature stage. This phenomenon of the Mo dopant segregation at the surface in NCM523 material was discovered in the present work for the first time. It appears that Mo doping reduces the reactivity of the Ni-rich NCM cathode materials toward the standard electrolyte solutions of Li-ion batteries. Using density functional theory (DFT) calculations, we showed that Mo6+ions are preferably incorporated at Ni sites and that the doping increases the amount of Ni2+ions at the expense of Ni3+ions, due to charge compensation, in accord with X-ray absorption fine structure (XAFS) spectroscopy measurements. Furthermore, DFT calculations predicted Ni–O bond length distributions in good agreement with the XAFS results, supporting a model of partial substitution of Ni sites by molybdenum.

Published
2018
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31. Non-covalent Monolayer-Piercing Anchoring of Lipophilic Nucleic Acids: Preparation, Characterization, and Sensing Applications

Author

Kwiat, Moria, primary, Elnathan, Roey, additional, Kwak, Minseok, additional, de Vries, Jan Willem, additional, Pevzner, Alexander, additional, Engel, Yoni, additional, Burstein, Larisa, additional, Khatchtourints, Artium, additional, Lichtenstein, Amir, additional, Flaxer, Eli, additional, Herrmann, Andreas, additional, and Patolsky, Fernando, additional

Published
2011
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38. Electrochemical Activation of Li 2 MnO 3 Electrodes at 0 °C and Its Impact on the Subsequent Performance at Higher Temperatures.

Author

Susai, Francis Amalraj, Talianker, Michael, Liu, Jing, Rosy, Paul, Tanmoy, Grinblat, Yehudit, Erickson, Evan, Noked, Malachi, Burstein, Larisa, Frenkel, Anatoly I., Tsur, Yoed, Markovsky, Boris, and Aurbach, Doron

Subjects
HIGH temperatures, INTERFACE stability, ELECTRODES, SURFACE chemistry, LITHIUM-ion batteries, MANGANESE alloys, ELECTROCHEMICAL electrodes
Abstract

This work continues our systematic study of Li- and Mn- rich cathodes for lithium-ion batteries. We chose Li2MnO3 as a model electrode material with the aim of correlating the improved electrochemical characteristics of these cathodes initially activated at 0 °C with the structural evolution of Li2MnO3, oxygen loss, formation of per-oxo like species (O22−) and the surface chemistry. It was established that performing a few initial charge/discharge (activation) cycles of Li2MnO3 at 0 °C resulted in increased discharge capacity and higher capacity retention, and decreased and substantially stabilized the voltage hysteresis upon subsequent cycling at 30 °C or at 45 °C. In contrast to the activation of Li2MnO3 at these higher temperatures, Li2MnO3 underwent step-by-step activation at 0 °C, providing a stepwise traversing of the voltage plateau at >4.5 V during initial cycling. Importantly, these findings agree well with our previous studies on the activation at 0 °C of 0.35Li2MnO3·0.65Li[Mn0.45Ni0.35Co0.20]O2 materials. The stability of the interface developed at 0 °C can be ascribed to the reduced interactions of the per-oxo-like species formed and the oxygen released from Li2MnO3 with solvents in ethylene carbonate–methyl-ethyl carbonate/LiPF6 solutions. Our TEM studies revealed that typically, upon initial cycling both at 0 °C and 30 °C, Li2MnO3 underwent partial structural layered-to-spinel (Li2Mn2O4) transition. [ABSTRACT FROM AUTHOR]

Published
2020
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39. Non-covalent Monolayer-Piercing Anchoring of Lipophilic Nucleic Acids

Author

Eli Flaxer, Moria Kwiat, Jan Willem de Vries, Fernando Patolsky, Yoni Engel, Roey Elnathan, Andreas Herrmann, Artium Khatchtourints, Minseok Kwak, Alexander Pevzner, Amir Lichtenstein, Larisa Burstein, Polymer Chemistry and Bioengineering, Nanotechnology and Biophysics in Medicine (NANOBIOMED), Kwiat, Moria, Elnathan, Roey, Kwak, Minseok, De, Vries Jan, Pevzner, Alexander, Engel, Yoni, Burstein, Larisa, Khatchtourints, Artium, Lichtenstein, Amir, Flaxer, Eli, Hermann, Andreas, and Patolsky, Fernando

Subjects
Models, Molecular, Silicon, Hot Temperature, DEVICES, Surface Properties, Supramolecular chemistry, Nanotechnology, Biosensing Techniques, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, Contact angle, chemistry.chemical_compound, Colloid and Surface Chemistry, LABEL-FREE DETECTION, Amphiphile, Monolayer, BLOCK-COPOLYMER MICELLES, SENSORS, Bifunctional, AMPHIPHILES, Electrodes, chemistry.chemical_classification, Base Sequence, ELECTRICAL DETECTION, Biomolecule, DNA HYBRIDIZATION, Nucleic Acid Hybridization, DNA, General Chemistry, Quartz crystal microbalance, 021001 nanoscience & nanotechnology, ALKANETHIOL MONOLAYERS, 0104 chemical sciences, nucleic acids, Oligodeoxyribonucleotides, Semiconductors, chemistry, Nucleic Acid Conformation, Glass, Gold, FIELD-EFFECT TRANSISTORS, 0210 nano-technology, Hydrophobic and Hydrophilic Interactions, Biosensor, SILICON NANOWIRES
Abstract

Functional interfaces of biomolecules and inorganic substrates like semiconductor materials are of utmost importance for the development of highly sensitive biosensors and microarray technology. However, there is still a lot of room for improving the techniques for immobilization of biomolecules, in particular nucleic acids and proteins. Conventional anchoring strategies rely on attaching biomacromolecules via complementary functional groups, appropriate bifunctional linker molecules, or non-covalent immobilization via electrostatic interactions. In this work, we demonstrate a facile, new, and general method for the reversible non-covalent attachment of amphiphilic DNA probes containing hydrophobic units attached to the nucleobases (lipid-DNA) onto SAM-modified gold electrodes, silicon semiconductor surfaces, and glass substrates. We show the anchoring of well-defined amounts of lipid-DNA onto the surface by insertion of their lipid tails into the hydrophobic monolayer structure. The surface coverage of DNA molecules can be conveniently controlled by modulating the initial concentration and incubation time. Further control over the DNA layer is afforded by the additional external stimulus of temperature. Heating the DNA-modified surfaces at temperatures > 80 degrees C leads to the release of the lipid-DNA structures from the surface without harming the integrity of the hydrophobic SAMs. These supramolecular DNA layers can be further tuned by anchoring onto a mixed SAM containing hydrophobic molecules of different lengths, rather than a homogeneous SAM. Immobilization of lipid-DNA on such SAMs has revealed that the surface density of DNA probes is highly dependent on the composition of the surface layer and the structure of the lipid-DNA. The formation of the lipid-DNA sensing layers was monitored and characterized by numerous techniques including X-ray photoelectron spectroscopy, quartz crystal microbalance, ellipsometry, contact angle measurements, atomic force microscopy, and confocal fluorescence imaging. Finally, this new DNA modification strategy was applied for the sensing of target DNAs using silicon-nanowire field-effect transistor device arrays, showing a high degree of specificity toward the complementary DNA target, as well as single-base mismatch selectivity.

Published
2012

40. Biorecognition layer engineering: overcoming screening limitations of nanowire-based FET devices

Author

Amir Lichtenstein, Yoni Engel, Larisa Burstein, Raisa Kantaev, Artium Khatchtourints, Fernando Patolsky, Alexander Pevzner, Moria Kwiat, Roey Elnathan, Elnathan, Roey, Kwiat, Moria, Pevzner, Alexander, Engel, Yoni, Burstein, Larisa, Khatchtourints, Artium, Lichtenstein, Amir, Kantaev, Raisa, and Patolsky, Fernando

Subjects
Materials science, Transistors, Electronic, Silicon dioxide, Nanowire, Ionic bonding, Nanotechnology, Bioengineering, Biosensing Techniques, Microscopy, Atomic Force, biomolecules, chemistry.chemical_compound, Immunoglobulin Fab Fragments, Troponin T, Quantum Dots, field effect transistors, ionic screening, Humans, General Materials Science, chemistry.chemical_classification, antibody fragments, Nanowires, Mechanical Engineering, Biomolecule, Osmolar Concentration, General Chemistry, Blood Proteins, Condensed Matter Physics, biosensors, Silicon Dioxide, Chemical species, chemistry, Ionic strength, nanowire, Biosensor, Layer (electronics), ionic strength, Antibodies, Immobilized, Biomarkers, Blood Chemical Analysis
Abstract

Detection of biological species is of great importance to numerous areas of medical and life sciences from the diagnosis of diseases to the discovery of new drugs. Essential to the detection mechanism is the transduction of a signal associated with the specific recognition of biomolecules of interest. Nanowire-based electrical devices have been demonstrated as a powerful sensing platform for the highly sensitive detection of a wide-range of biological and chemical species. Yet, detecting biomolecules in complex biosamples of high ionic strength (>100 mM) is severely hampered by ionic screening effects. As a consequence, most of existing nanowire sensors operate under low ionic strength conditions, requiring ex situ biosample manipulation steps, that is, desalting processes. Here, we demonstrate an effective approach for the direct detection of biomolecules in untreated serum, based on the fragmentation of antibody-capturing units. Size-reduced antibody fragments permit the biorecognition event to occur in closer proximity to the nanowire surface, falling within the charge-sensitive Debye screening length. Furthermore, we explored the effect of antibody surface coverage on the resulting detection sensitivity limit under the high ionic strength conditions tested and found that lower antibody surface densities, in contrary to high antibody surface coverage, leads to devices of greater sensitivities. Thus, the direct and sensitive detection of proteins in untreated serum and blood samples was effectively performed down to the sub-pM concentration range without the requirement of biosamples manipulation. Refereed/Peer-reviewed

Published
2012

41. Understanding the Role of Minor Molybdenum Doping in LiNi 0.5 Co 0.2 Mn 0.3 O 2 Electrodes: from Structural and Surface Analyses and Theoretical Modeling to Practical Electrochemical Cells.

Author

Breuer O, Chakraborty A, Liu J, Kravchuk T, Burstein L, Grinblat J, Kauffman Y, Gladkih A, Nayak P, Tsubery M, Frenkel AI, Talianker M, Major DT, Markovsky B, and Aurbach D

Abstract

Doping LiNi 0.5 Co 0.2 Mn 0.3 O 2 (NCM523) cathode material by small amount of Mo 6+ ions, around 1 mol %, affects pronouncedly its structure, surface properties, and electronic and electrochemical behavior. Cathodes comprising Mo 6+ -doped NCM523 exhibited in Li cells higher specific capacities, higher rate capabilities, lower capacity fading, and lower charge-transfer resistance that relates to a more stable electrode/solution interface due to doping. This, in turn, is ascribed to the fact that the Mo 6+ ions tend to concentrate more at the surface, as a result of a synthesis that always includes a necessary calcination, high-temperature stage. This phenomenon of the Mo dopant segregation at the surface in NCM523 material was discovered in the present work for the first time. It appears that Mo doping reduces the reactivity of the Ni-rich NCM cathode materials toward the standard electrolyte solutions of Li-ion batteries. Using density functional theory (DFT) calculations, we showed that Mo 6+ ions are preferably incorporated at Ni sites and that the doping increases the amount of Ni 2+ ions at the expense of Ni 3+ ions, due to charge compensation, in accord with X-ray absorption fine structure (XAFS) spectroscopy measurements. Furthermore, DFT calculations predicted Ni-O bond length distributions in good agreement with the XAFS results, supporting a model of partial substitution of Ni sites by molybdenum.

Published
2018
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