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29 results on '"Burzawa, Jennifer K."'

1. Supplementary Tables 1-6 from Uterine Lavage Identifies Cancer Mutations and Increased TP53 Somatic Mutation Burden in Individuals with Ovarian Cancer

Author

Ghezelayagh, Talayeh S., primary, Kohrn, Brendan F., primary, Fredrickson, Jeanne, primary, Manhardt, Enna, primary, Radke, Marc R., primary, Katz, Ronit, primary, Gray, Heidi J., primary, Urban, Renata R., primary, Pennington, Kathryn P., primary, Liao, John B., primary, Doll, Kemi M., primary, Simons, Elise J., primary, Burzawa, Jennifer K., primary, Goff, Barbara A., primary, Speiser, Paul, primary, Swisher, Elizabeth M., primary, Norquist, Barbara M., primary, and Risques, Rosa Ana, primary

Published
2023
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2. Data from Uterine Lavage Identifies Cancer Mutations and Increased TP53 Somatic Mutation Burden in Individuals with Ovarian Cancer

Author

Ghezelayagh, Talayeh S., primary, Kohrn, Brendan F., primary, Fredrickson, Jeanne, primary, Manhardt, Enna, primary, Radke, Marc R., primary, Katz, Ronit, primary, Gray, Heidi J., primary, Urban, Renata R., primary, Pennington, Kathryn P., primary, Liao, John B., primary, Doll, Kemi M., primary, Simons, Elise J., primary, Burzawa, Jennifer K., primary, Goff, Barbara A., primary, Speiser, Paul, primary, Swisher, Elizabeth M., primary, Norquist, Barbara M., primary, and Risques, Rosa Ana, primary

Published
2023
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3. Supplementary Figures 1-11 from Uterine Lavage Identifies Cancer Mutations and Increased TP53 Somatic Mutation Burden in Individuals with Ovarian Cancer

Author

Ghezelayagh, Talayeh S., primary, Kohrn, Brendan F., primary, Fredrickson, Jeanne, primary, Manhardt, Enna, primary, Radke, Marc R., primary, Katz, Ronit, primary, Gray, Heidi J., primary, Urban, Renata R., primary, Pennington, Kathryn P., primary, Liao, John B., primary, Doll, Kemi M., primary, Simons, Elise J., primary, Burzawa, Jennifer K., primary, Goff, Barbara A., primary, Speiser, Paul, primary, Swisher, Elizabeth M., primary, Norquist, Barbara M., primary, and Risques, Rosa Ana, primary

Published
2023
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4. Supplementary Methods from Uterine Lavage Identifies Cancer Mutations and Increased TP53 Somatic Mutation Burden in Individuals with Ovarian Cancer

Author

Ghezelayagh, Talayeh S., primary, Kohrn, Brendan F., primary, Fredrickson, Jeanne, primary, Manhardt, Enna, primary, Radke, Marc R., primary, Katz, Ronit, primary, Gray, Heidi J., primary, Urban, Renata R., primary, Pennington, Kathryn P., primary, Liao, John B., primary, Doll, Kemi M., primary, Simons, Elise J., primary, Burzawa, Jennifer K., primary, Goff, Barbara A., primary, Speiser, Paul, primary, Swisher, Elizabeth M., primary, Norquist, Barbara M., primary, and Risques, Rosa Ana, primary

Published
2023
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8. Uterine Lavage Identifies Cancer Mutations and Increased TP53 Somatic Mutation Burden in Individuals with Ovarian Cancer

Author

Ghezelayagh, Talayeh S., primary, Kohrn, Brendan F., additional, Fredrickson, Jeanne, additional, Manhardt, Enna, additional, Radke, Marc R., additional, Katz, Ronit, additional, Gray, Heidi J., additional, Urban, Renata R., additional, Pennington, Kathryn P., additional, Liao, John B., additional, Doll, Kemi M., additional, Simons, Elise J., additional, Burzawa, Jennifer K., additional, Goff, Barbara A., additional, Speiser, Paul, additional, Swisher, Elizabeth M., additional, Norquist, Barbara M., additional, and Risques, Rosa Ana, additional

Published
2022
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10. Abstract LB047: Uterine lavage for the detection of ovarian cancer using an expanded gene panel

Author

Ghezelayagh, Talayeh, primary, Fredrickson, Jeanne, additional, Manhardt, Enna, additional, Radke, Marc R., additional, Kohrn, Brendan, additional, Gray, Heidi J., additional, Urban, Renata R., additional, Pennington, Kathryn P., additional, Liao, John B., additional, Doll, Kemi M., additional, Simons, Elise J., additional, Burzawa, Jennifer K., additional, Goff, Barbara A., additional, Speiser, Paul, additional, Swisher, Elizabeth M., additional, Risques, Rosa Ana, additional, and Norquist, Barbara M., additional

Published
2021
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13. Prospective phase II trial of levonorgestrel intrauterine device: nonsurgical approach for complex atypical hyperplasia and early-stage endometrial cancer

Author

Westin, Shannon N., primary, Fellman, Bryan, additional, Sun, Charlotte C., additional, Broaddus, Russell R., additional, Woodall, Misty L., additional, Pal, Navdeep, additional, Urbauer, Diana L., additional, Ramondetta, Lois M., additional, Schmeler, Kathleen M., additional, Soliman, Pamela T., additional, Fleming, Nicole D., additional, Burzawa, Jennifer K., additional, Nick, Alpa M., additional, Milbourne, Andrea M., additional, Yuan, Ying, additional, Lu, Karen H., additional, Bodurka, Diane C., additional, Coleman, Robert L., additional, and Yates, Melinda S., additional

Published
2021
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14. Relaxin Signaling in Uterine Fibroids

Author

Li, Zhen, Burzawa, Jennifer K., Troung, Anne, Feng, Shu, Agoulnik, Irina U., Tong, Xiaowen, Anderson, Matthew L., Kovanci, Ertug, Rajkovic, Aleksandar, and Agoulnik, Alexander I.

Published
2009
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15. Correlation of surgeon radiology assessment with laparoscopic scoring in patients with advanced-stage ovarian cancer.

Author

Fleming, Nicole D., primary, Westin, Shannon Neville, additional, Meyer, Larissa, additional, Rauh-Hain, Jose Alejandro, additional, Shafer, Aaron, additional, Onstad, Michaela, additional, Cobb, Lauren Patterson, additional, Bevers, Michael W., additional, Burzawa, Jennifer K., additional, Zand, Behrouz, additional, Fellman, Bryan M., additional, Jazaeri, Amir A., additional, Levenback, Charles F., additional, Coleman, Robert L., additional, Soliman, Pamela T., additional, and Sood, Anil K, additional

Published
2019
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16. Endometrial Cancer Associated Symptoms: A Case-Control Study

Author

Pakish, Janelle B., primary, Lu, Karen H., additional, Sun, Charlotte C., additional, Burzawa, Jennifer K., additional, Greisinger, Anthony, additional, Smith, Frances A., additional, Fellman, Bryan, additional, Urbauer, Diana L., additional, and Soliman, Pamela T., additional

Published
2016
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17. What Is the Real Rate of Surgical Site Infection?

Author

Taylor, Jolyn S., primary, Marten, Claire A., additional, Potts, Kimberly A., additional, Cloutier, Lynn M., additional, Cain, Katherine E., additional, Fenton, Shauna L., additional, Tatum, Tara N., additional, James, Deepthi A., additional, Myers, Keith N., additional, Hubbs, Cheryl A., additional, Burzawa, Jennifer K., additional, Vachhani, Shital, additional, Nick, Alpa M., additional, Meyer, Larissa A., additional, Graviss, Linda S., additional, Ware, Kathy M., additional, Park, Anne K., additional, Aloia, Thomas A., additional, Bodurka, Diane C., additional, Levenback, Charles F., additional, and Schmeler, Kathleen M., additional

Published
2016
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19. The DISINFECT Initiative: Decreasing the Incidence of Surgical INFECTions in Gynecologic Oncology

Author

Taylor, Jolyn S., primary, Marten, Claire A., additional, Munsell, Mark F., additional, Sun, Charlotte C., additional, Potts, Kimberly A., additional, Burzawa, Jennifer K., additional, Nick, Alpa M., additional, Meyer, Larissa A., additional, Myers, Keith, additional, Bodurka, Diane C., additional, Aloia, Thomas A., additional, Levenback, Charles F., additional, Lairson, David R., additional, and Schmeler, Kathleen M., additional

Published
2016
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21. Symptoms of endometrial cancer.

Author

Pakish, Janelle B., primary, Lu, Karen H., additional, Sun, Charlotte C., additional, Burzawa, Jennifer K., additional, Greisinger, Anthony, additional, Smith, Frances A, additional, Fellman, Bryan, additional, Urbauer, Diana L, additional, and Soliman, Pamela T., additional

Published
2015
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23. Prospective evaluation of the molecular effects of metformin on the endometrium in women with newly diagnosed endometrial cancer: A window of opportunity study.

Author

Soliman, Pamela T., primary, Broaddus, Russell, additional, Westin, Shannon Neville, additional, Iglesias, David A., additional, Burzawa, Jennifer K., additional, Zhang, Qian, additional, Munsell, Mark F., additional, Schmandt, Rosemarie, additional, Ramondetta, Lois M., additional, Lu, Karen H., additional, and Bae-Jump, Victoria Lin, additional

Published
2014
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28. Chemopreventive effects of metformin on obesity-associated endometrial proliferation.

Author

Qian Zhang, Celestino, Joseph, Schmandt, Rosemarie, McCampbell, Adrienne S., Urbauer, Diana L., Meyer, Larissa A., Burzawa, Jennifer K., Huang, Marilyn, Yates, Melinda S., Iglesias, David, Broaddus, Russell R., and Lu, Karen H.

Subjects
METFORMIN, OBESITY, ENDOMETRIAL cancer risk factors, CANCER chemoprevention, CANCER cell proliferation, INSULIN resistance, HYPERINSULINISM, LABORATORY rats
Abstract

OBJECTIVE: Obesity is a significant contributing factor to endometrial cancer risk. We previously demonstrated that estrogen-induced endometrial proliferation is enhanced in the context of hyper-insulinemia and insulin resistance. In this study, we investigate whether pharmacologic agents that modulate insulin sensitivity or normalize insulin levels will diminish the proliferative response to estrogen. STUDY DESIGN: Zucker fa/fa obese rats and lean controls were used as models of hyperinsulinemia and insulin resistance. Insulin levels were depleted in ovariectomized rats following treatment with streptozotocin, or modulated by metformin treatment. The number of BrdU-incorporated cells, estrogen-dependent proliferative and antiproliferative gene expression, and activation of mTOR and ERK1/2 MAPK signaling were studied. A rat normal endometrial cell line RENE1 was used to evaluate the direct effects of metformin on endometrial cell proliferation and gene expression in vitro. RESULTS: Streptozotocin lowered circulating insulin levels in obese rats and decreased the number of BrdU-labeled endometrial cells even in the presence of exogenous estrogen. Treatment with the insulin-sensitizing drug metformin attenuated estrogen-dependent proliferative expression of c-myc and c-fos in the obese rat endometrium compared to untreated controls and was accompanied by inhibition of phosphorylation of the insulin and IGF1 receptors (IRβ/IGF1R) and ERK1/2. In vitro studies indicated metformin inhibited RENE1 proliferation in a dose-dependent manner. CONCLUSION: These findings suggest that drugs that modulate insulin sensitivity, such as metformin, hinder estrogen-mediated endometrial proliferation. Therefore, these drugs may be clinically useful for the prevention of endometrial cancer in obese women. [ABSTRACT FROM AUTHOR]

Published
2013
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29. Improvement in quality of life after robotic surgery results in patient satisfaction.

Author

IIIArms, Richard G., Sun, Charlotte C., Burzawa, Jennifer K., Fleming, Nicole D., Nick, Alpa M., Rallapalli, Vijayashri, Westin, Shannon N., Meyer, Larissa A., Ramirez, Pedro T., and Soliman, Pamela T.

Subjects
*QUALITY of life, *SURGICAL robots, *PATIENT satisfaction, *ONCOLOGY, *GYNECOLOGIC cancer
Abstract

Background There are well-described benefits to minimally invasive surgery including decreased blood loss, shorter hospital-stay, and faster recovery. The role of robotic surgery in gynecologic oncology has become increasingly prominent; however limited data are available on quality of life (QOL) after robotic surgery. Methods In this prospective, IRB-approved study, women scheduled for robotic surgery for a gynecologic indication between May 2008 and February 2012 completed validated QOL measures at baseline, 6 weeks (6 wk), and 4 months postoperative (4 mo). Functional status (SF-12), symptom severity and interference (MDASI), sexual function (FSFI), and satisfaction with decision (SWD) were assessed at relevant time points. Differences between groups were evaluated using the Mann–Whitney test. Results Among 408 women who underwent robotic surgery 278 (68%) completed the QOL measures. Median age was 55.6 years (range 25.7–85.1). Median BMI was 31.3 kg/m 2 . The majority of patients were white (75%). The most common indication for surgery was endometrial cancer/hyperplasia (59.7%). While physical functioning declined from baseline to 6 wk (51.4 to 41.6, p < 0.001), it improved by 4 mo (53.5). Mental functioning improved over time (baseline 48.6, 6 wk 52.8, and 4 mo 55.6, p < 0.001). Symptom severity decreased over time (p < 0.001) as did symptom interference (p < 0.001). Sexual function improved significantly from baseline (8.6) to 4 mo (20.2, p < 0.001). Patients were satisfied with their decision making (SWD = 30). Conclusion In this prospective study, general health, symptom burden and sexual function returned to or improved beyond baseline levels within 6 weeks of surgery. Overall, women were satisfied with their decision to undergo robotic surgery. [ABSTRACT FROM AUTHOR]

Published
2015
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