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Your search keyword '"Burzynska, Agnieszka Z."' showing total 42 results
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42 results on '"Burzynska, Agnieszka Z."'

5. Brain Network Modularity Predicts Exercise-Related Executive Function Gains in Older Adults

Author

Baniqued, Pauline L, Gallen, Courtney L, Voss, Michelle W, Burzynska, Agnieszka Z, Wong, Chelsea N, Cooke, Gillian E, Duffy, Kristin, Fanning, Jason, Ehlers, Diane K, Salerno, Elizabeth A, Aguiñaga, Susan, McAuley, Edward, Kramer, Arthur F, and D'Esposito, Mark

Subjects
Biological Psychology, Psychology, Applied and Developmental Psychology, Prevention, Behavioral and Social Science, Aging, Clinical Research, Underpinning research, 1.2 Psychological and socioeconomic processes, Neurological, executive function, cognitive control, functional connectivity, exercise, brain network modularity, Biochemistry and Cell Biology, Neurosciences, Cognitive Sciences, Biological psychology
Abstract

Recent work suggests that the brain can be conceptualized as a network comprised of groups of sub-networks or modules. The extent of segregation between modules can be quantified with a modularity metric, where networks with high modularity have dense connections within modules and sparser connections between modules. Previous work has shown that higher modularity predicts greater improvements after cognitive training in patients with traumatic brain injury and in healthy older and young adults. It is not known, however, whether modularity can also predict cognitive gains after a physical exercise intervention. Here, we quantified modularity in older adults (N = 128, mean age = 64.74) who underwent one of the following interventions for 6 months (NCT01472744 on ClinicalTrials.gov): (1) aerobic exercise in the form of brisk walking (Walk), (2) aerobic exercise in the form of brisk walking plus nutritional supplement (Walk+), (3) stretching, strengthening and stability (SSS), or (4) dance instruction. After the intervention, the Walk, Walk+ and SSS groups showed gains in cardiorespiratory fitness (CRF), with larger effects in both walking groups compared to the SSS and Dance groups. The Walk, Walk+ and SSS groups also improved in executive function (EF) as measured by reasoning, working memory, and task-switching tests. In the Walk, Walk+, and SSS groups that improved in EF, higher baseline modularity was positively related to EF gains, even after controlling for age, in-scanner motion and baseline EF. No relationship between modularity and EF gains was observed in the Dance group, which did not show training-related gains in CRF or EF control. These results are consistent with previous studies demonstrating that individuals with a more modular brain network organization are more responsive to cognitive training. These findings suggest that the predictive power of modularity may be generalizable across interventions aimed to enhance aspects of cognition and that, especially in low-performing individuals, global network properties can capture individual differences in neuroplasticity.

Published
2018

17. White matter microstructure mediates the relationship between cardiorespiratory fitness and spatial working memory in older adults☆

Author

Oberlin, Lauren E., Verstynen, Timothy D., Burzynska, Agnieszka Z., Voss, Michelle W., Prakash, Ruchika Shaurya, Chaddock-Heyman, Laura, Wong, Chelsea, Fanning, Jason, Awick, Elizabeth, Gothe, Neha, Phillips, Siobhan M., Mailey, Emily, Ehlers, Diane, Olson, Erin, Wojcicki, Thomas, McAuley, Edward, Kramer, Arthur F., and Erickson, Kirk I.

Published
2016
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24. Standard‐space atlas of the viscoelastic properties of the human brain

Author

Hiscox, Lucy V., primary, McGarry, Matthew D. J., additional, Schwarb, Hillary, additional, Van Houten, Elijah E. W., additional, Pohlig, Ryan T., additional, Roberts, Neil, additional, Huesmann, Graham R., additional, Burzynska, Agnieszka Z., additional, Sutton, Bradley P., additional, Hillman, Charles H., additional, Kramer, Arthur F., additional, Cohen, Neal J., additional, Barbey, Aron K., additional, Paulsen, Keith D., additional, and Johnson, Curtis L., additional

Published
2020
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30. Brain Network Modularity Predicts Exercise-Related Executive Function Gains in Older Adults.

Author

Baniqued, Pauline L, Baniqued, Pauline L, Gallen, Courtney L, Voss, Michelle W, Burzynska, Agnieszka Z, Wong, Chelsea N, Cooke, Gillian E, Duffy, Kristin, Fanning, Jason, Ehlers, Diane K, Salerno, Elizabeth A, Aguiñaga, Susan, McAuley, Edward, Kramer, Arthur F, D'Esposito, Mark, Baniqued, Pauline L, Baniqued, Pauline L, Gallen, Courtney L, Voss, Michelle W, Burzynska, Agnieszka Z, Wong, Chelsea N, Cooke, Gillian E, Duffy, Kristin, Fanning, Jason, Ehlers, Diane K, Salerno, Elizabeth A, Aguiñaga, Susan, McAuley, Edward, Kramer, Arthur F, and D'Esposito, Mark

Abstract

Recent work suggests that the brain can be conceptualized as a network comprised of groups of sub-networks or modules. The extent of segregation between modules can be quantified with a modularity metric, where networks with high modularity have dense connections within modules and sparser connections between modules. Previous work has shown that higher modularity predicts greater improvements after cognitive training in patients with traumatic brain injury and in healthy older and young adults. It is not known, however, whether modularity can also predict cognitive gains after a physical exercise intervention. Here, we quantified modularity in older adults (N = 128, mean age = 64.74) who underwent one of the following interventions for 6 months (NCT01472744 on ClinicalTrials.gov): (1) aerobic exercise in the form of brisk walking (Walk), (2) aerobic exercise in the form of brisk walking plus nutritional supplement (Walk+), (3) stretching, strengthening and stability (SSS), or (4) dance instruction. After the intervention, the Walk, Walk+ and SSS groups showed gains in cardiorespiratory fitness (CRF), with larger effects in both walking groups compared to the SSS and Dance groups. The Walk, Walk+ and SSS groups also improved in executive function (EF) as measured by reasoning, working memory, and task-switching tests. In the Walk, Walk+, and SSS groups that improved in EF, higher baseline modularity was positively related to EF gains, even after controlling for age, in-scanner motion and baseline EF. No relationship between modularity and EF gains was observed in the Dance group, which did not show training-related gains in CRF or EF control. These results are consistent with previous studies demonstrating that individuals with a more modular brain network organization are more responsive to cognitive training. These findings suggest that the predictive power of modularity may be generalizable across interventions aimed to enhance aspects of cognition and that, espe

Published
2017

34. Physical Activity Is Linked to Greater Moment-To-Moment Variability in Spontaneous Brain Activity in Older Adults

Author

Wong, Chelsea N. and Burzynska, Agnieszka Z.

Abstract

Higher cardiorespiratory fitness (CRF) and physical activity (PA) in old age are associated with greater brain structural and functional integrity, and higher cognitive functioning. However, it is not known how different aspects of lifestyle such as sedentariness, light PA (LI-PA), or moderate-to-vigorous physical activity (MV-PA) relate to neural activity in aging. In addition, it is not known whether the effects of PA on brain function differ or overlap with those of CRF. Here, we objectively measured CRF as oxygen consumption during a maximal exercise test and measured PA with an accelerometer worn for 7 days in 100 healthy but low active older adults (aged 60–80 years). We modeled the relationships between CRF, PA, and brain functional integrity using multivariate partial least squares analysis. As an index of functional brain integrity we used spontaneous moment-to-moment variability in the blood oxygenation level-dependent signal (SDBOLD), known to be associated with better cognitive functioning in aging. We found that older adults who engaged more in LI-PA and MV-PA had greater SDBOLD in brain regions that play a role in integrating segregated functional domains in the brain and benefit from greater CRF or PA, such as precuneus, hippocampus, medial and lateral prefrontal, and temporal cortices. Our results suggest that engaging in higher intensity PA may have protective effects on neural processing in aging. Finally, we demonstrated that older adults with greater overall WM microstructure were those showing more LI-PA and MV-PA and greater SDBOLD. We conclude that SDBOLD is a promising correlate of functional brain health in aging. Future analyses will evaluate whether SDBOLD is modifiable with interventions aimed to increase PA and CRF in older adults.

Published
2015

35. Adult-Life Occupational Exposures: Enriched Environment or a Stressor for the Aging Brain?

Author

Burzynska, Agnieszka Z, Jiao, Yuqin, and Ganster, Daniel C

Subjects
AGING, MENTAL health, COGNITIVE ability, DEMOGRAPHIC change, RETIREMENT, BRAIN stimulation, INDUSTRIAL psychology
Abstract

Demographic changes and economic demands of aging populations are raising the age of retirement. It is common knowledge that one's occupation is associated with socioeconomic status, and also has a significant impact on physical and mental health. However, research on the long-term effects of employment on cognition and brain health in old age is still rare. Understanding occupational factors shaping our brains is necessary to develop interventions at the workplace, aimed at optimizing neurocognitive outcomes in old age. This review outlines the emerging empirical research on the relationships between occupational characteristics and cognitive and brain aging. We propose the "brain aging: occupational stimulation and stress" (BOSS) model that outlines the long-term interplay of antiaging (occupational stimulation or environmental enrichment) and proaging factors (occupational stress) on the development and aging of the adult mind and brain. The BOSS model outlines the mechanisms of the employment–brain relationships that include immune system, cortisol responsivity, neurotrophins, hypertension, and sleep quality. Existing at the intersection of organizational psychology, developmental sciences, and neuroscience, the BOSS model offers a framework for future "occupational neuroscience" research. We argue that decisions on retirement age should be viewed not only from an economic, but also from a public health perspective. We conclude that occupational activities need to be acknowledged as an important factor in lifespan cognitive and brain development. [ABSTRACT FROM AUTHOR]

Published
2019
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36. Brain activation during dual-task processing is associated with cardiorespiratory fitness and performance in older adults

Author

Wong, Chelsea N., primary, Chaddock-Heyman, Laura, additional, Voss, Michelle W., additional, Burzynska, Agnieszka Z., additional, Basak, Chandramallika, additional, Erickson, Kirk I., additional, Prakash, Ruchika S., additional, Szabo-Reed, Amanda N., additional, Phillips, Siobhan M., additional, Wojcicki, Thomas, additional, Mailey, Emily L., additional, McAuley, Edward, additional, and Kramer, Arthur F., additional

Published
2015
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39. Enriched Environments for Healthy Aging: Qualities of Seniors Housing Designs Promoting Brain and Cognitive Health.

Author

Burzynska, Agnieszka Z. and Malinin, Laura H.

Subjects
SENIOR housing, INDEPENDENT living, AGING, HEALTH of older people, COGNITION disorders in old age, CONGREGATE housing, BUILDING design & construction
Abstract

Problem: By the year 2050, nearly one in four people in the world will be over the age of 60. Cognitive functioning is the strongest predictor of a person's ability to maintain independence through activities of daily living. Seniors housing designs do not typically consider users' cognitive health. The Resolution: We link high-quality experimental research in neuroscience and architectural design through the neuroscience concept of Enriched Environments to support long-term maintenance of cognitive performance and neural health in the older population. Tips for Success: Designing seniors housing to promote neurocognitive health requires a sufficient level of environmental complexity, achieved by providing "enriched" spaces that are physically, socially, and cognitively stimulating. Enriched Environments offer therapeutic challenge, complementing universal designs that emphasize accessibility through minimal environmental challenge. [ABSTRACT FROM AUTHOR]

Published
2017

40. A Scaffold for Efficiency in the Human Brain

Author

Burzynska, Agnieszka Z., Garrett, Douglas D., Preuschhof, Claudia, Nagel, Irene E., Li, Shu-Chen, Bäckman, Lars, Heekeren, Hauke R., Lindenberger, Ulman, Burzynska, Agnieszka Z., Garrett, Douglas D., Preuschhof, Claudia, Nagel, Irene E., Li, Shu-Chen, Bäckman, Lars, Heekeren, Hauke R., and Lindenberger, Ulman

Abstract

The comprehensive relations between healthy adult human brain white matter(WM) microstructure and gray matter (GM) function, and their joint relations to cognitive performance, remain poorly understood. We investigated these associations in 27 younger and 28 older healthy adults by linking diffusion tensor imaging (DTI) with functional magnetic resonance imaging (fMRI) data collected during an n-back working memory task. We present a novel application of multivariate Partial Least Squares (PLS) analysis that permitted the simultaneous modeling of relations between WM integrity values from all major WM tracts and patterns of condition-related BOLD signal across all GM regions. Our results indicate that greater microstructural integrity of the major WM tracts was negatively related to condition-related blood oxygenation level-dependent (BOLD) signal in task-positive GM regions. This negative relationship suggests that better quality of structural connections allows for more efficient use of task-related GM processing resources. Individuals with more intact WM further showed greater BOLD signal increases in typical task-negative regions during fixation, and notably exhibited a balanced magnitude of BOLD response across task-positive and-negative states. Structure-function relations also predicted task performance, including accuracy and speed of responding. Finally, structure-function behavior relations reflected individual differences over and above chronological age. Our findings provide evidence for the role of WM microstructure as a scaffold for the context-relevant utilization of GM regions., AuthorCount:8;Funding Agencies:Max Planck Society-University College London Initiative for Computational Psychiatry and Ageing Research (ICPAR); Swedish Research Council; Swedish Brain Power, an Alexander von Humboldt Research Award; Jochnick Foundation

Published
2013
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41. A Scaffold for Efficiency in the Human Brain

Author

Burzynska, Agnieszka Z., primary, Garrett, Douglas D., additional, Preuschhof, Claudia, additional, Nagel, Irene E., additional, Li, Shu-Chen, additional, Bäckman, Lars, additional, Heekeren, Hauke R., additional, and Lindenberger, Ulman, additional

Published
2013
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