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16 results on '"Bustos, Raul"'

1. A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study)

Author

O’Hearn, Katie, Menon, Kusum, Weiler, Hope A., Amrein, Karin, Fergusson, Dean, Gunz, Anna, Bustos, Raul, Campos, Roberto, Catalan, Valentina, Roedl, Siegfried, Tsampalieros, Anne, Barrowman, Nick, Geier, Pavel, Henderson, Matthew, Khamessan, Ali, Lawson, Margaret L., McIntyre, Lauralyn, Redpath, Stephanie, Jones, Glenville, Kaufmann, Martin, and McNally, Dayre

Published
2023
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2. A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study)

Author

O’Hearn, Katie, primary, Menon, Kusum, additional, Weiler, Hope A., additional, Amrein, Karin, additional, Fergusson, Dean, additional, Gunz, Anna, additional, Bustos, Raul, additional, Campos, Roberto, additional, Catalan, Valentina, additional, Roedl, Siegfried, additional, Tsampalieros, Anne, additional, Barrowman, Nick, additional, Geier, Pavel, additional, Henderson, Matthew, additional, Khamessan, Ali, additional, Lawson, Margaret L., additional, McIntyre, Lauralyn, additional, Redpath, Stephanie, additional, Jones, Glenville, additional, Kaufmann, Martin, additional, and McNally, Dayre, additional

Published
2023
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3. A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study).

Author

O'Hearn, Katie, Menon, Kusum, Weiler, Hope A., Amrein, Karin, Fergusson, Dean, Gunz, Anna, Bustos, Raul, Campos, Roberto, Catalan, Valentina, Roedl, Siegfried, Tsampalieros, Anne, Barrowman, Nick, Geier, Pavel, Henderson, Matthew, Khamessan, Ali, Lawson, Margaret L., McIntyre, Lauralyn, Redpath, Stephanie, Jones, Glenville, and Kaufmann, Martin

Subjects
CRITICALLY ill children, VITAMIN D deficiency, CHOLECALCIFEROL, CLINICAL trials, QUALITY of life, ENTERAL feeding, FEEDING tubes
Abstract

Background: Vitamin D deficiency (VDD) is highly prevalent in the pediatric intensive care unit (ICU) and associated with worse clinical course. Trials in adult ICU demonstrate rapid restoration of vitamin D status using an enteral loading dose is safe and may improve outcomes. There have been no published trials of rapid normalization of VDD in the pediatric ICU. Methods: We conducted a multicenter placebo-controlled phase II pilot feasibility randomized clinical trial from 2016 to 2017. We randomized 67 critically ill children with VDD from ICUs in Canada, Chile and Austria using a 2:1 randomization ratio to receive a loading dose of enteral cholecalciferol (10,000 IU/kg, maximum of 400,000 IU) or placebo. Participants, care givers, and outcomes assessors were blinded. The primary objective was to determine whether the loading dose normalized vitamin D status (25(OH)D > 75 nmol/L). Secondary objectives were to evaluate for adverse events and assess the feasibility of a phase III trial. Results: Of 67 randomized participants, one was withdrawn and seven received more than one dose of cholecalciferol before the protocol was amended to a single loading dose, leaving 59 participants in the primary analyses (40 treatment, 19 placebo). Thirty-one/38 (81.6%) participants in the treatment arm achieved a plasma 25(OH)D concentration > 75 nmol/L versus 1/18 (5.6%) the placebo arm. The mean 25(OH)D concentration in the treatment arm was 125.9 nmol/L (SD 63.4). There was no evidence of vitamin D toxicity and no major drug or safety protocol violations. The accrual rate was 3.4 patients/month, supporting feasibility of a larger trial. A day 7 blood sample was collected for 84% of patients. A survey administered to 40 participating families showed that health-related quality of life (HRQL) was the most important outcome for families for the main trial (30, 75%). Conclusions: A single 10,000 IU/kg dose can rapidly and safely normalize plasma 25(OH)D concentrations in critically ill children with VDD, but with significant variability in 25(OH)D concentrations. We established that a phase III multicentre trial is feasible. Using an outcome collected after hospital discharge (HRQL) will require strategies to minimize loss-to-follow-up. Trial Registration. Clinicaltrials.gov NCT02452762 Registered 25/05/2015. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Adrenal schwannoma in a female patient; A rare benign neoplasm: Case report and literature review

Author

Jafif Cojab, Marcos, primary, Flores Armenta, Jesus, additional, Jorge, Diego L., additional, Sanchez Hernandez, Rodrigo, additional, Cervantes Gutierrez, Oscar, additional, Brener Chaoul, Moises, additional, Moedano Rico, Karen, additional, Cuevas Bustos, Raul, additional, Perez Tristan, Felix Alejandro, additional, Acuña Macouzet, Alejandro, additional, Gonzalez Woge, Miguel, additional, Zamora Duarte, Luis Miguel, additional, Cervantes Millan, Gustavo, additional, Melendez Sanchez, Jose Miguel, additional, and Garcia Mendez, Ana Karen, additional

Published
2020
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7. Gallbladder osteoma in a 66-year-old female; Case report and review of literature

Author

Valdes Castañeda, Alberto, primary, Cuevas Bustos, Raul Alexander, additional, Brener Chaoul, Moises, additional, Jafif Cojab, Marcos, additional, Arribas Martin, Juan Pablo, additional, Mancera Steiner, Carlos, additional, Jorge, Diego L., additional, Velasco Vales, Maria Veronica, additional, Cervantes Gutierrez, Oscar, additional, Flores-Huidobro Martinez, Angel, additional, and Perez Tristan, Felix Alejandro, additional

Published
2020
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9. Advances in the determination of alcohol and other drug consumption during pregnancy: a study of 900 births in Montevideo, Uruguay.

Author

Magri, Raquel, Hutson, Janine, Miguez, Hugo, Suarez, Hector, Menendez, Adriana, Parodi, Veronica, Koren, Gideon, and Bustos, Raul

Subjects
Drug abuse in pregnancy -- Research, Drinking in pregnancy -- Research, Substance abuse -- Research
Abstract

Background For a long time numerous studies have shown that alcohol and other drug consumption during fetal gestation causes diverse health problems for the mother and child (American Academy of [...], A study was performed in Uruguay to estimate the prevalence of drug consumption during pregnancy. The study consisted of a survey and biological samples to validate the responses and investigate information concerning risks involved in drug consumption during pregnancy. The survey consisted of 900 face-to-face interviews performed within 48 hours after birth. Perinatal registries were taken from hospital archives. Nine hundred meconium samples were tested for alcohol, tobacco, illegal drugs, and tranquilizers. The results of the survey indicated consumption during pregnancy of the following: 41.3% tobacco, 36.8% alcohol, 16.3% tranquilizers, 68% caffeine (more than 400 mg/day), and 1.4% illegal drugs. In addition, 8.9% of the pregnancies were unplanned. Among the planned pregnancies, some physicians warned their patients about risks associated with tobacco (34%), alcohol (27%) and illegal drugs (7%). Meconium analysis revealed tobacco (cotinine), 51.8%; alcohol (fatty acid ethyl esters, or FAEES), 43.5%; and cocaine (base paste), 2.5%. Newborns whose mothers smoked tobacco presented statistically lower birth weights: 11% of all newborns at low birth weight, with health problems reported for 14.8%. KEY WORDS: Newborn, alcohol, drugs, caffeine, mate, pregnancy information.

Published
2007

10. Effectiveness of Two Targeted Temperature Management Methods After Pediatric Postcardiac Arrest

Author

Yunge, Mauricio, primary, Cordero, Jaime, additional, Martinez, Daniela, additional, Bustos, Raul, additional, Wegner, Adriana, additional, Castro, Magdalena, additional, Arrau, Lorena, additional, Diaz, Betsy, additional, Dalmazzo, Roberto, additional, Hickmann, Lilian, additional, Lapadula, Michelangelo, additional, Yañez, Leticia, additional, Roque, Jorge, additional, Cecchetti, Corrado, additional, Bravo, Pablo, additional, Cruces, Pablo, additional, Acuña, Carlos, additional, Oyaguez, Pablo, additional, Miras, Alicia, additional, Morales, Antonio, additional, Nieto, Manuel, additional, Lopez, Yolanda, additional, Morales, Gonzalo, additional, Drago, Michele, additional, Nalegach, Maria Elisa, additional, Sepulveda, German, additional, Menchaca, Amanda, additional, Jerez, Florencia, additional, Glasinovic, Maritza, additional, Mallea, Fernando, additional, and Lopez-Herce, Jesus, additional

Published
2019
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13. High-Dose Intravenous Methylprednisolone for Hantavirus Cardiopulmonary Syndrome in Chile: A Double-Blind, Randomized Controlled Clinical Trial

Author

Vial, Pablo A., primary, Valdivieso, Francisca, additional, Ferres, Marcela, additional, Riquelme, Raul, additional, Rioseco, M. Luisa, additional, Calvo, Mario, additional, Castillo, Constanza, additional, Díaz, Ricardo, additional, Scholz, Luis, additional, Cuiza, Analia, additional, Belmar, Edith, additional, Hernandez, Carla, additional, Martinez, Jessica, additional, Lee, Sang-Joon, additional, Mertz, Gregory J., additional, Abarca, Juan, additional, Tomicic, Vinko, additional, Aracena, M. Eugenia, additional, Rehbein, Ana Maria, additional, Velásquez, Soledad, additional, Lavin, Victoria, additional, Garrido, Felipe, additional, Godoy, Paula, additional, Martinez, Constanza, additional, Chamorro, Juan Carlos, additional, Contreras, Jorge, additional, Hernandez, Jury, additional, Pino, Marcelo, additional, Villegas, Paola, additional, Zapata, Viviana, additional, León, Marisol, additional, Vega, Ivonne, additional, Otarola, Irisol, additional, Ortega, Carlos, additional, Daube, Elizabeth, additional, Huecha, Doris, additional, Neira, Alda, additional, Ruiz, Ines, additional, Nuñez, M. Antonieta, additional, Monsalve, Luz, additional, Chabouty, Henriette, additional, Riquelme, Lorena, additional, Palma, Samia, additional, Bustos, Raul, additional, Miranda, Ruben, additional, Mardones, Jovita, additional, Hernandez, Nora, additional, Betancur, Yasna, additional, Sanhueza, Ligia, additional, Inostroza, Jaime, additional, Donoso, Solange, additional, Navarrete, Maritza, additional, Acuña, Lily, additional, Manriquez, Paulina, additional, Castillo, Fabiola, additional, Unzueta, Paola, additional, Aguilera, Teresa, additional, Osorio, Carola, additional, Yobanolo, Veronica, additional, Mardones, Jorge, additional, Aranda, Sandra, additional, Carvajal, Soledad, additional, Sandoval, Moisés, additional, Daza, Soraya, additional, Vargas, Felipe, additional, Diaz, Violeta, additional, Riquelme, Mauricio, additional, Muñoz, Miriam, additional, Carriel, Andrea, additional, Lanino, Paola, additional, Hernandez, Susana, additional, Schumacher, Patricia, additional, Yañez, Lia, additional, Marco, Claudia, additional, Ehrenfeld, Mildred, additional, Delgado, Iris, additional, Rios, Susana, additional, Vial, Cecilia, additional, and Bedrick, Edward, additional

Published
2013
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15. Significance of phosphatidylglycerol in amniotic fluid in complicated pregnancies

Author

Bustos, Raul, Kulovich, Marie V., Gluck, Louis, Gabbe, Steven G., Evertson, Larry, Vargas, Carlos, and Lowenberg, Eduardo

Abstract

In normal pregnancy lecithin/sphingomyelin ratios correlate with gestational age. In complicated pregnancies biochemical maturation of fetal lung may be accelerated or delayed, depending upon maternal, fetal, or placental conditions. Surfactant contains other phospholipids besides lecithin, including phosphatidylglycerol (PG), the second major component of mature surfactant. Ninety phospholipid patterns in amniotic fluid were studied by two-dimensional thin-layer chromatography. In uncomplicated pregnancies PG was absent until 37 weeks' gestation, then increased thereafter. In complicated pregnancies (pre-eclampsia, diabetes Classes D, F, and R, premature rupture of membranes) PG was identified before 35 (as early as 29) weeks' gestation. These results verify accelerated lung maturation in certain complicated pregnancies. No newborn infant developed respiratory distress syndrome in the presence of PG.

Published
1979
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