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4. Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization

Author

D’Amato, Gennaro, Holgate, Stephen T., Pawankar, Ruby, Ledford, Dennis K., Cecchi, Lorenzo, Al-Ahmad, Mona, Al-Enezi, Fatma, Al-Muhsen, Saleh, Ansotegui, Ignacio, Baena-Cagnani, Carlos E., Baker, David J., Bayram, Hasan, Bergmann, Karl Christian, Boulet, Louis-Philippe, Buters, Jeroen T.M., D’Amato, Maria, Dorsano, Sofia, Douwes, Jeroen, Finlay, Sarah Elise, Garrasi, Donata, Gómez, Maximiliano, Haahtela, Tari, Halwani, Rabih, Hassani, Youssouf, Mahboub, Basam, Marks, Guy, Michelozzi, Paola, Montagni, Marcello, Nunes, Carlos, Oh, Jay Jae-Won, Popov, Todor A., Portnoy, Jay, Ridolo, Erminia, Rosário, Nelson, Rottem, Menachem, Sánchez-Borges, Mario, Sibanda, Elopy, Sienra-Monge, Juan José, Vitale, Carolina, and Annesi-Maesano, Isabella

Published
2015
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5. Higher airborne pollen concentrations correlated with increased SARS-CoV-2 infection rates, as evidenced from 31 countries across the globe

Author

Damialis, Athanasios, Gilles, Stefanie, Sofiev, Mikhail, Sofieva, Viktoria, Kolek, Franziska, Bayr, Daniela, Plaza, Maria P., Leier-Wirtz, Vivien, Kaschuba, Sigrid, Ziska, Lewis H., Bielory, Leonard, Makra, László, del Mar Trigo, Maria, Traidl-Hoffmann, Claudia, Oliver, Gilles, Pham-Thi, Nhân, Thibaudon, Michel, Arino, Arturo H., Belmonte, Jordina, Cervigon Morales, Patricia, De Linares, Concepción, Fernández, Delia, Fernández-Rodriguez, Santiago, Gabaldón Arguisuelas, Antonia, Galán, Carmen, González-Alonso, Mónica, Lara, Beatriz, Moreno Grau, José María, Oteros, José, Pérez-Badia, Rosa, Pérez-De-Zabalza, Anabel, Picornell, Antonio, Recio, Marta, Robles, Estrella, Rodríguez-Fernández, Alberto, Rodríguez-Rajo, F. Javier, Rojo, Jesús, Ruiz Valenzuela, Luis, Bergmann, Karl Christian, Werchan, Barbora, Werchan, Matthias, Buters, Jeroen T.M., Bastl, Maximilian, Dunker, Susanne, Hornick, Thomas, González Roldán, Nestor, Gilge, Stefan, Clot, Bernard, Finemann, Stanley, Ford, Linda, Gomez, Robert Anthony, Kamboj, Sanjay, Wilhelm, Wayne, Beggs, Paul J., Burton, Pamela, Davies, Janet M., Haberle, Simon Graeme, Katelaris, Constance Helen, Keaney, Ben, Milic, Andelija, Miller, Victoria, van Haeften, Shanice, Bonini, Maira, Bordin, Anna, Ceriotti, Valentina, Cristofolini, Fabiana, Cristofori, Antonella, Gottardini, Elena, Marcer, Guido, Marraccini, Paolo, Mascagni, Paolo, Meriggi, Antonio, Pace, Loretta, Pini, Alberto, Tacca, Maria Cristina, Bruffaerts, Nicolas, Hoebeke, Lucie, Adams-Groom, Beverley, Pashley, Catherine H., Satchwell, Jack, Skjøth, Carsten, Symon, Fiona A., Antunes, Celia M., Caeiro, Elsa, Camacho, Irene Gomes Câmara, Costa, Ana R., Deus, Ricardo João Ratola Capela, Ferreira, Manuel Branco, Fonseca, Joao Almeida Lopes, Galveias, Ana, Ribeiro, Helena, Tavares, Beatriz, Grewling, Łukasz, Grinn-Gofroń, Agnieszka, Jurkiewicz, Dariusz, Kalinowska, Ewa, Lipiec, Agnieszka, Myszkowska, Dorota, Piotrowska-Weryszko, Krystyna, Puc, Malgorzata, Rapiejko, Anna, Rapiejko, Piotr, Weryszko-Chmielewska, Elzbieta, Ziemianin, Monika, Berman, Dilys, Hoek, Werner, Manjra, Ahmed Ismail, Peter, Jonathan, Dahl, Åslög, Ekebom, Agneta, Stjepanovic, Barbara, Večenaj, Ana, Celenk, Sevcan, Göksel, Özlem, Göksel, Tuncay, Guvensen, Aykut A., Munevver, Nur, Sackesen, Cansin, Acar Sahin, Aydar, Uguz, Ulas U., Yazici, Duygu, Kajtor-Apatini, Dóra, Magyar, Donat, Szigeti, Tamas, Sikoparija, Branko, Kofol Seliger, Andreja, Simčič, Anja, Charalampopoulos, Athanasios, Vokou, Despoina, Rasmussen, Karen, Barrionuevo, Laura Beatriz, Ramon, German Dario, de Weger, Letty A., Koenders, Mieke M.J.F., van Vliet, Arnold J.H., Dušička, Jozef, Lafférsová, Janka, Šèevkováč, Jana, Rybníček, Ondøej, Coates, Frances, Jurgens, Dawn, Šauliene, Ingrida, Severova, Elena, Rodinkova, Victoria, Bortnyk, Mykyta, Palamarchuk, Olena, Yasniuk, Maryna, Louna-Korteniemi, Maria, Pätsi, Sanna, Saarto, Annika, Toiviainen, Linnea, Sozinova, Olga, Jia, Peng, other, and, Damialis, Athanasios, Gilles, Stefanie, Sofiev, Mikhail, Sofieva, Viktoria, Kolek, Franziska, Bayr, Daniela, Plaza, Maria P., Leier-Wirtz, Vivien, Kaschuba, Sigrid, Ziska, Lewis H., Bielory, Leonard, Makra, László, del Mar Trigo, Maria, Traidl-Hoffmann, Claudia, Oliver, Gilles, Pham-Thi, Nhân, Thibaudon, Michel, Arino, Arturo H., Belmonte, Jordina, Cervigon Morales, Patricia, De Linares, Concepción, Fernández, Delia, Fernández-Rodriguez, Santiago, Gabaldón Arguisuelas, Antonia, Galán, Carmen, González-Alonso, Mónica, Lara, Beatriz, Moreno Grau, José María, Oteros, José, Pérez-Badia, Rosa, Pérez-De-Zabalza, Anabel, Picornell, Antonio, Recio, Marta, Robles, Estrella, Rodríguez-Fernández, Alberto, Rodríguez-Rajo, F. Javier, Rojo, Jesús, Ruiz Valenzuela, Luis, Bergmann, Karl Christian, Werchan, Barbora, Werchan, Matthias, Buters, Jeroen T.M., Bastl, Maximilian, Dunker, Susanne, Hornick, Thomas, González Roldán, Nestor, Gilge, Stefan, Clot, Bernard, Finemann, Stanley, Ford, Linda, Gomez, Robert Anthony, Kamboj, Sanjay, Wilhelm, Wayne, Beggs, Paul J., Burton, Pamela, Davies, Janet M., Haberle, Simon Graeme, Katelaris, Constance Helen, Keaney, Ben, Milic, Andelija, Miller, Victoria, van Haeften, Shanice, Bonini, Maira, Bordin, Anna, Ceriotti, Valentina, Cristofolini, Fabiana, Cristofori, Antonella, Gottardini, Elena, Marcer, Guido, Marraccini, Paolo, Mascagni, Paolo, Meriggi, Antonio, Pace, Loretta, Pini, Alberto, Tacca, Maria Cristina, Bruffaerts, Nicolas, Hoebeke, Lucie, Adams-Groom, Beverley, Pashley, Catherine H., Satchwell, Jack, Skjøth, Carsten, Symon, Fiona A., Antunes, Celia M., Caeiro, Elsa, Camacho, Irene Gomes Câmara, Costa, Ana R., Deus, Ricardo João Ratola Capela, Ferreira, Manuel Branco, Fonseca, Joao Almeida Lopes, Galveias, Ana, Ribeiro, Helena, Tavares, Beatriz, Grewling, Łukasz, Grinn-Gofroń, Agnieszka, Jurkiewicz, Dariusz, Kalinowska, Ewa, Lipiec, Agnieszka, Myszkowska, Dorota, Piotrowska-Weryszko, Krystyna, Puc, Malgorzata, Rapiejko, Anna, Rapiejko, Piotr, Weryszko-Chmielewska, Elzbieta, Ziemianin, Monika, Berman, Dilys, Hoek, Werner, Manjra, Ahmed Ismail, Peter, Jonathan, Dahl, Åslög, Ekebom, Agneta, Stjepanovic, Barbara, Večenaj, Ana, Celenk, Sevcan, Göksel, Özlem, Göksel, Tuncay, Guvensen, Aykut A., Munevver, Nur, Sackesen, Cansin, Acar Sahin, Aydar, Uguz, Ulas U., Yazici, Duygu, Kajtor-Apatini, Dóra, Magyar, Donat, Szigeti, Tamas, Sikoparija, Branko, Kofol Seliger, Andreja, Simčič, Anja, Charalampopoulos, Athanasios, Vokou, Despoina, Rasmussen, Karen, Barrionuevo, Laura Beatriz, Ramon, German Dario, de Weger, Letty A., Koenders, Mieke M.J.F., van Vliet, Arnold J.H., Dušička, Jozef, Lafférsová, Janka, Šèevkováč, Jana, Rybníček, Ondøej, Coates, Frances, Jurgens, Dawn, Šauliene, Ingrida, Severova, Elena, Rodinkova, Victoria, Bortnyk, Mykyta, Palamarchuk, Olena, Yasniuk, Maryna, Louna-Korteniemi, Maria, Pätsi, Sanna, Saarto, Annika, Toiviainen, Linnea, Sozinova, Olga, Jia, Peng, and other, and

Abstract

Pollen exposure weakens the immunity against certain seasonal respiratory viruses by diminishing the antiviral interferon response. Here we investigate whether the same applies to the pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is sensitive to antiviral interferons, if infection waves coincide with high airborne pollen concentrations. Our original hypothesis was that more airborne pollen would lead to increases in infection rates. To examine this, we performed a cross-sectional and longitudinal data analysis on SARS-CoV-2 infection, airborne pollen, and meteorological factors. Our dataset is the most comprehensive, largest possible worldwide from 130 stations, across 31 countries and five continents. To explicitly investigate the effects of social contact, we additionally considered population density of each study area, as well as lockdown effects, in all possible combinations: without any lockdown, with mixed lockdown−no lockdown regime, and under complete lockdown. We found that airborne pollen, sometimes in synergy with humidity and temperature, explained, on average, 44% of the infection rate variability. Infection rates increased after higher pollen concentrations most frequently during the four previous days. Without lockdown, an increase of pollen abundance by 100 pollen/m3 resulted in a 4% average increase of infection rates. Lockdown halved infection rates under similar pollen concentrations. As there can be no preventive measures against airborne pollen exposure, we suggest wide dissemination of pollen−virus coexposure dire effect information to encourage high-risk individuals to wear particle filter masks during high springtime pollen concentrations.

Published
2021

6. Anwendung von biologika bei allergischen und Typ-2-entzündlichen Erkrankungen in der aktuellen COVID-19-Pandemie

Author

Klimek, Ludger, Pfaar, Dr O., Worm, Margitta M., Eiwegger, Thomas, Hagemann, Jan, Ollert, Markus W., Untersmayr, Eva, Hoffmann-Sommergruber, Karin, Vultaggio, Alessandra, Agache, Ioana O., Bavbek, S., Bossios, Apostolos, Casper, Ingrid, Chan, Susan, Chatzipetrou, A., Vogelberg, Christian, Firinu, Davide, Kauppi, P., Kolios, Antonios G.A., Kothari, Akash, Matucci, Andrea, Palomares, Óscar, Szépfalusi, Zsolt, Hötzenecker, Wolfram, Rosenkranz, A. R., Bergmann, Karl Christian, Bieber, Thomas, Buhl, Roland, Buters, Jeroen T.M., Darsow, Ulf G., Keil, Thomas, Kleine-Tebbe, Jörg, Lau, S., Maurer, Marcus, Merk, Hans Friedrich, Mösges, Ralph, Saloga, Joachim, Staubach, Petra, Jappe, Uta, Rabe, Klaus Friedrich, Rabe, Uta, Vogelmeier, Claus Franz, Biedermann, Tilo M., Jung, Kirsten, Schlenter, Wolfgang W., Ring, Johannnes, Chaker, Adam M., Wehrmann, Wolfgang, Becker, Sven, Freudelsperger, Laura, Mülleneisen, Norbert K., Nemat, Katja, Czech, Wolfgang, Wrede, Holger, Brehler, Randolph B.S., Fuchs, Thomas, Tomazic, Peter Valentin, Aberer, Werner, Fink-Wagner, Antjie Henriette, Horak, Friedrich, Wöhrl, Stefan, Niederberger-Leppin, Verena, Pali-Schöll, Isabella, Pohl, Wolfgang, Roller-Wirnsberger, Regina Elisabeth, Spranger, Otto, Valenta, Rudolf, Akdis, Mübeccel, Matricardi, Paolo Maria, Spertini, François, Khaltaev, Nikolaï G., Michel, Jean Pierre, Nicod, Laurent Pierre, Schmid-Grendelmeier, Peter D., Idzko, Marco, Hamelmann, E., Jakob, Thilo, Werfel, Thomas Andreas, Wagenmann, Martin M., Taube, Christian, Jensen-Jarolim, Erika, Korn, Stephanie, Hentges, François R., Schwarze, Jürgen, O'Mahony, Liam, Knol, Edward Frank, del Giacco, Stefano R., Chivato Pérez, T., Bousquet, Jean J., Zuberbier, Thorsten, Akdis, Cezmi A., Jutel, Marek, MACVIA-France, Montpellier, Centre de recherche en épidémiologie et santé des populations (CESP), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)

Subjects
SARS-CoV-2, [SDV]Life Sciences [q-bio], Benralizumab, Omalizumab, Dupilumab, Reslizumab, Covid-19, ComputingMilieux_MISCELLANEOUS, Mepolizumab, Telemedicine
Abstract

International audience

Published
2020

7. Allergen immunotherapy in the current COVID-19 pandemic - A position paper of the AeDA, ARIA, EAACI, DGAKI and GPA

Author

Klimek, Ludger, Pfaar, Dr O., Worm, Margitta M., Bergmann, Karl Christian, Bieber, Thomas, Buhl, Roland, Buters, Jeroen T.M., Darsow, Ulf G., Keil, Thomas, Kleine-Tebbe, Jörg, Lau, Susanne, Maurer, Mar, Merk, Hans Friedrich, Mösges, Ralph, Saloga, Joachim, Staubach, Petra, Stute, P., Rabe, Klaus, Rabe, Uta, Vogelmeier, Claus Franz, Biedermann, Tilo M., Jung, Kirsten, Schlenter, Wolfgang W., Ring, Johannnes, Chaker, Adam M., Wehrmann, Wolfgang, Becker, Sven, Mülleneisen, Norbert K., Nemat, Katja, Czech, Wolfgang, Wrede, Holger, Brehler, Randolph B.S., Fuchs, Thomas, Tomazic, Peter Valentin, Aberer, Werner, Fink-Wagner, Antjie Henriette, Horak, Friedrich, Wöhrl, Stefan, Niederberger-Leppin, Verena, Pali-Schöll, Isabella, Pohl, Wolfgang, Roller-Wirnsberger, Regina Elisabeth, Spranger, Otto, Valenta, Rudolf, Akdis, Mübeccel, Akdis, Cezmi A., Hoffmann-Sommergruber, Karin, Jutel, Marek, Matricardi, Paolo Maria, Spertini, François, Khaltaev, Nikolaï G., Michel, Jean Pierre, Nicod, Laurent, Schmid-Grendelmeier, Peter D., Hamelmann, E., Jakob, Thilo, Werfel, Thomas Andreas, Wagenmann, Martin, Taube, Christian, Gerstlauer, Michael, Vogelberg, Christian, Bousquet, Jean J., Zuberbier, Torsten, Rheinische Friedrich-Wilhelms-Universität Bonn, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
SLIT, [SDV]Life Sciences [q-bio], COVID-19, Antiviral immunity, SCIT, ComputingMilieux_MISCELLANEOUS, Allergen immunotherapy
Abstract

International audience

Published
2020

8. Handling of allergen immunotherapy in the COVID-19 pandemic: An ARIA-EAACI-AeDA-GPA-DGAKI Position Paper (Pocket-Guide)

Author

Pfaar, Oliver, Klimek, Ludger, Worm, Margitta M., Bergmann, Karl Christian, Bieber, Thomas, Buhl, Roland, Buters, Jeroen T.M., Darsow, Ulf G., Keil, T., Kleine-Tebbe, Jörg, Lau, S., Maurer, Marcus, Merk, Hans Friedrich, Mösges, Ralph, Saloga, Joachim, Staubach, Petra, Stute, P., Rabe, K., Rabe, Uta, Vogelmeier, Claus Franz, Biedermann, Tilo M., Jung, K., Schlenter, Wolfgang W., Ring, J., Chaker, Adam M., Wehrmann, Wolfgang, Becker, Sven, Mülleneisen, Norbert K., Nemat, Katja, Czech, Wolfgang, Wrede, Holger, Brehler, Randolph B.S., Fuchs, Thomas, Tomazic, Peter Valentin, Aberer, Werner, Fink-Wagner, Antjie Henriette, Horak, Friedrich, Wöhrl, Stefan, Niederberger-Leppin, Verena, Pali-Schöll, Isabella, Pohl, Wolfgang, Roller-Wirnsberger, Regina Elisabeth, Spranger, Otto, Valenta, Rudolf, Akdis, Mübeccel, Akdis, Cezmi A., Hoffmann-Sommergruber, Karin, Jutel, Marek, Matricardi, Paolo Maria, Spertini, François, Khaltaev, Nikolaï G., Michel, Jean Pierre, Nicod, Laurent Pierre, Schmid-Grendelmeier, Peter D., Hamelmann, E., Jakob, Thilo, Werfel, Thomas Andreas, Wagenmann, Martin M., Taube, C., Gerstlauer, Michael, Vogelberg, Christian, Bousquet, Jean J., Zuberbier, Thorsten, Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), FMC VIA LR, 371, avenue Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), and Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)

Subjects
[SHS.LANGUE]Humanities and Social Sciences/Linguistics, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

11. Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz(a)anthracene-induced lymphomas

Author

Buters, Jeroen T.M., Sakai, Shuichi, Richter, Thomas, Pineau, Thierry, Alexander, David L., Savas, Uzen, Doehmer, Johannes, Ward, Jerrold M., Jefcoate, Colin R., and Gonzalez, Frank J.

Subjects
Cytochrome P-450 -- Research, Lymphomas -- Research, Mice as laboratory animals -- Research, Science and technology
Abstract

CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype, thus establishing that CYP1B1 is not required for mouse development. CYP1B1 was not detectable in cultured embryonic fibroblast (EF) or in different tissues, such as lung, of the CYP1B1-null mouse treated with the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin whereas the equivalent wild-type EF cells express basal and substantial inducible CYP1B1 and lung expresses inducible CYP1B1. CYP1A1 is induced to far higher levels than CYP1B1 in liver, kidney, and lung in wild-type mice and is induced to a similar extent in CYP1B1-null mice. 7,12-dimethylbenz[a]anthracene (DMBA) was toxic in wild-type EFs that express CYP1B1 but not CYP1A1. These cells effectively metabolized DMBA, consistent with CYP1B1 involvement in producing the procarcinogenic 3,4-dihydrodiol as a major metabolite, whereas CYP1B1-null EF showed no significant metabolism and were resistant to DMBA-mediated toxicity. When wild-type mice were administered high levels of DMBA intragastrically, 70% developed highly malignant lymphomas whereas only 7.5% of CYP1B1-null mice had lymphomas. Skin hyperplasia and tumors were also more frequent in wild-type mice. These results establish that CYP1B1, located exclusively at extrahepatic sites, mediates the carcinogenicity of DMBA. Surprisingly, CYP1A1, which has a high rate of DMBA metabolism in vitro, is not sufficient for this carcinogenesis, which demonstrates the importance of extrahepatic P450s in determining susceptibility to chemical carcinogens and validates the search for associations between P450 expression and cancer risk in humans.

Published
1999

12. Building an automatic pollen monitoring network (ePIN): Selection of optimal sites by clustering pollen stations

Author

Oteros, Jose, primary, Sofiev, Mikhail, additional, Smith, Matt, additional, Clot, Bernard, additional, Damialis, Athanasios, additional, Prank, Marje, additional, Werchan, Matthias, additional, Wachter, Reinhard, additional, Weber, Alisa, additional, Kutzora, Susanne, additional, Heinze, Stefanie, additional, Herr, Caroline E.W., additional, Menzel, Annette, additional, Bergmann, Karl-Christian, additional, Traidl-Hoffmann, Claudia, additional, Schmidt-Weber, Carsten B., additional, and Buters, Jeroen T.M., additional

Published
2019
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13. First comparison of symptom data with allergen content (Bet v 1 and Phl p 5 measurements) and pollen data from four European regions during 2009–2011

Author

Bastl, Katharina, primary, Kmenta, Maximilian, additional, Pessi, Anna-Mari, additional, Prank, Marje, additional, Saarto, Annika, additional, Sofiev, Mikhail, additional, Bergmann, Karl-Christian, additional, Buters, Jeroen T.M., additional, Thibaudon, Michel, additional, Jäger, Siegfried, additional, and Berger, Uwe, additional

Published
2016
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14. Automatic and Online Pollen Monitoring

Author

Oteros, Jose, primary, Pusch, Gudrun, additional, Weichenmeier, Ingrid, additional, Heimann, Ulrich, additional, Möller, Rouven, additional, Röseler, Stefani, additional, Traidl-Hoffmann, Claudia, additional, Schmidt-Weber, Carsten, additional, and Buters, Jeroen T.M., additional

Published
2015
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15. Release of Bet v 1 from birch pollen from 5 European countries. Results from the HIALINE study

Author

Buters, Jeroen T.M., primary, Thibaudon, Michel, additional, Smith, Matt, additional, Kennedy, Roy, additional, Rantio-Lehtimäki, Auli, additional, Albertini, Roberto, additional, Reese, Gerald, additional, Weber, Bernhard, additional, Galan, Carmen, additional, Brandao, Rui, additional, Antunes, Celia M., additional, Jäger, Siegfried, additional, Berger, Uwe, additional, Celenk, Sevcan, additional, Grewling, Łukasz, additional, Jackowiak, Bogdan, additional, Sauliene, Ingrida, additional, Weichenmeier, Ingrid, additional, Pusch, Gudrun, additional, Sarioglu, Hakan, additional, Ueffing, Marius, additional, Behrendt, Heidrun, additional, Prank, Marje, additional, Sofiev, Mikhail, additional, and Cecchi, Lorenzo, additional

Published
2012
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19. Year-to-Year Variation in Release of Bet v 1 Allergen from Birch Pollen: Evidence for Geographical Differences between West and South Germany

Author

Buters, Jeroen T.M., primary, Kasche, Anna, additional, Weichenmeier, Ingrid, additional, Schober, Wolfgang, additional, Klaus, Sabrina, additional, Traidl-Hoffmann, Claudia, additional, Menzel, Annette, additional, Huss-Marp, Johannes, additional, Krämer, Ursula, additional, and Behrendt, Heidrun, additional

Published
2007
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31. Comparison of substrate metabolism by wild type CYP2D6 protein and a variant containing methionine, not valine, at position 374

Author

Crespi, Charles L., primary, Steimel, Dorothy T., additional, Penman, Bruce W., additional, Korzekwa, Kenneth R., additional, Fernandez-Salguero, Pedro, additional, Buters, Jeroen T.M., additional, Gelboin, Harry V., additional, Gonzalez, Frank J., additional, Idle, Jeffrey R., additional, and Daly, Ann K., additional

Published
1995
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34. Particulate Matter from Both Heavy Fuel Oil and Diesel Fuel Shipping Emissions Show Strong Biological Effects on Human Lung Cells at Realistic and Comparable In Vitro Exposure Conditions

Author

Oeder, Sebastian, Kanashova, Tamara, Sippula, Olli, Sapcariu, Sean C., Streibel, Thorsten, Arteaga-Salas, Jose M., Passig, Johannes, Dilger, Marco, Paur, Hanns-Rudolf, Schlager, Christoph, Mulhopt, Sonja, Diabate, Silvia, Weiss, Carsten, Stengel, Benjamin, Rabe, Rom, Harndorf, Horst, Torvela, Tiina, Jokiniemi, Jorma K., Hirvonen, Maija-Riitta, Schmidt-Weber, Carsten, Traidl-Hoffmann, Claudia, BéruBé, Kelly A., Wlodarczyk, Anna J., Prytherch, Zoe, Michalke, Bernhard, Krebs, Tobias, Prévôt, André S.H., Kelbg, Michael, Tiggesbäumker, Josef, Karg, Erwin, Jakobi, Gert, Scholtes, Sorana, Schnelle-Kreis, Jürgen, Lintelmann, Jutta, Matuschek, Georg, Sklorz, Martin, Klingbeil, Sophie, Orasche, Jürgen, Richthammer, Patrick, Müller, Laarnie, Elsasser, Michael, Reda, Ahmed, Gröger, Thomas, Weggler, Benedikt, Schwemer, Theo, Czech, Hendryk, Rüger, Christopher P., Abbaszade, Gülcin, Radischat, Christian, Hiller, Karsten, Buters, Jeroen T.M., Dittmar, Gunnar, and Zimmermann, Ralf

Subjects
13. Climate action, complex mixtures, 3. Good health
Abstract

Background Ship engine emissions are important with regard to lung and cardiovascular diseases especially in coastal regions worldwide. Known cellular responses to combustion particles include oxidative stress and inflammatory signalling. Objectives To provide a molecular link between the chemical and physical characteristics of ship emission particles and the cellular responses they elicit and to identify potentially harmful fractions in shipping emission aerosols. Methods Through an air-liquid interface exposure system, we exposed human lung cells under realistic in vitro conditions to exhaust fumes from a ship engine running on either common heavy fuel oil (HFO) or cleaner-burning diesel fuel (DF). Advanced chemical analyses of the exhaust aerosols were combined with transcriptional, proteomic and metabolomic profiling including isotope labelling methods to characterise the lung cell responses. Results The HFO emissions contained high concentrations of toxic compounds such as metals and polycyclic aromatic hydrocarbon, and were higher in particle mass. These compounds were lower in DF emissions, which in turn had higher concentrations of elemental carbon (“soot”). Common cellular reactions included cellular stress responses and endocytosis. Reactions to HFO emissions were dominated by oxidative stress and inflammatory responses, whereas DF emissions induced generally a broader biological response than HFO emissions and affected essential cellular pathways such as energy metabolism, protein synthesis, and chromatin modification. Conclusions Despite a lower content of known toxic compounds, combustion particles from the clean shipping fuel DF influenced several essential pathways of lung cell metabolism more strongly than particles from the unrefined fuel HFO. This might be attributable to a higher soot content in DF. Thus the role of diesel soot, which is a known carcinogen in acute air pollution-induced health effects should be further investigated. For the use of HFO and DF we recommend a reduction of carbonaceous soot in the ship emissions by implementation of filtration devices., PLoS ONE, 10 (6), ISSN:1932-6203

35. Phl p 5 levels more strongly associated than grass pollen counts with allergic respiratory health

Author

Fuertes, Elaine, Jarvis, Debbie, Lam, Holly, Davies, Bethan, Fecht, Daniela, Candeias, Joana, Schmidt-Weber, Carsten B., Douiri, Abdel, Slovick, Anna, Scala, Enrico, Smith, Thomas, Shamji, Mohamed, Buters, Jeroen T.M., Cecchi, Lorenzo, Till, Stephen J., Fuertes, Elaine, Jarvis, Debbie, Lam, Holly, Davies, Bethan, Fecht, Daniela, Candeias, Joana, Schmidt-Weber, Carsten B., Douiri, Abdel, Slovick, Anna, Scala, Enrico, Smith, Thomas, Shamji, Mohamed, Buters, Jeroen T.M., Cecchi, Lorenzo, and Till, Stephen J.

Abstract

Background: Studies have linked daily pollen counts to respiratory allergic health outcomes, but few have considered allergen levels. Objective: We sought to assess associations of grass pollen counts and grass allergen levels (Phl p 5) with respiratory allergic health symptoms in a panel of 93 adults with moderate-severe allergic rhinitis and daily asthma hospital admissions in London, United Kingdom. Methods: Daily symptom and medication scores were collected from adult participants in an allergy clinical trial. Daily counts of asthma hospital admissions in the London general population were obtained from Hospital Episode Statistics data. Daily grass pollen counts were measured using a volumetric air sampler, and novel Phl p 5 levels were measured using a ChemVol High Volume Cascade Impactor and ELISA analyses (May through August). Associations between the 2 pollen variables and daily health scores (dichotomized based on within-person 75th percentiles) were assessed using generalized estimating equation logistic models and with asthma hospital admissions using Poisson regression models. Results: Daily pollen counts and Phl p 5 levels were each positively associated with reporting a high combined symptom and medication health score in separate models. However, in mutually adjusted models including terms for both pollen counts and Phl p 5 levels, associations remained for Phl p 5 levels (odds ratio [95% CI]: 1.18 [1.12, 1.24]), but were heavily attenuated for pollen counts (odds ratio [95% CI]: 1.00 [0.93, 1.07]). Similar trends were not observed for asthma hospital admissions in London. Conclusions: Grass allergen (Phl p 5) levels are more consistently associated with allergic respiratory symptoms than grass pollen counts.

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