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5. High incidence of resistant breakthrough invasive fungal infections (IFD) in patients treated for acute gastrointestinal graft-versus-host disease (GI GVHD) following allogeneic haematopoietic cell transplantation

Author

Yuan, Yin, Wong, Philip, Butler, Jason P., Henden, Andrea, Curley, Cameron, Durrant, Simon, Mediwake, Heshani, Morton, A. James, Stewart, Caroline, Subramoniapillai, Elango, Weber, Nicholas, Tey, Siok-Keen, Kennedy, Glen A., and Scott, Ashleigh P.

Published
2022
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6. Powerful Teaching and Learning in Social Studies: A Position Statement of National Council for the Social Studies

Author

National Council for the Social Studies, Pugh, Shannon M., McGuire, Margit E., Butler, Jason, Castillo, Jyoti, Moore, Daneel, Ramirez, Becky, and Russac, Patricia

Abstract

A comprehensive social studies education provides the foundation for an appreciation of democracy, an understanding of the responsibilities and rights that come with participating in a republican form of government, and the knowledge and skills to be informed, responsible, and active global citizens. As students participate in their social studies education, it is crucial that teachers implement powerful teaching and learning strategies because these are designed to best support students as they acquire the knowledge, skills, and dispositions essential to a well-educated populace in a democratic society and global system. Teaching social studies powerfully and authentically begins with a deep knowledge and understanding of students, the subject, and each subject's unique goals. Teachers must pursue ongoing professional development to develop a deep understanding of their subject and best practices centered in research-based social studies pedagogies in order to effectively build on the pillars that support powerful teaching and learning in social studies classrooms.

Published
2023

9. Tisagenlecleucel in adult relapsed or refractory follicular lymphoma: the phase 2 ELARA trial

Author

Fowler, Nathan Hale, Dickinson, Michael, Dreyling, Martin, Martinez-Lopez, Joaquin, Kolstad, Arne, Butler, Jason, Ghosh, Monalisa, Popplewell, Leslie, Chavez, Julio C., Bachy, Emmanuel, Kato, Koji, Harigae, Hideo, Kersten, Marie José, Andreadis, Charalambos, Riedell, Peter A., Ho, P. Joy, Pérez-Simón, José Antonio, Chen, Andy I., Nastoupil, Loretta J., von Tresckow, Bastian, Ferreri, Andrés José María, Teshima, Takanori, Patten, Piers E. M., McGuirk, Joseph P., Petzer, Andreas L., Offner, Fritz, Viardot, Andreas, Zinzani, Pier Luigi, Malladi, Ram, Zia, Aiesha, Awasthi, Rakesh, Masood, Aisha, Anak, Oezlem, Schuster, Stephen J., and Thieblemont, Catherine

Published
2022
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11. Inverse Saffman-Taylor experiments with particles lead to capillarity driven fingering instabilities

Author

Bihi, Ilyesse, Baudoin, Michael, Butler, Jason E., Faille, Christine, and Zoueshtiagh, Farzam

Subjects
Physics - Fluid Dynamics, Condensed Matter - Soft Condensed Matter
Abstract

Using air to displace a viscous fluid contained in Hele-Shaw cell can create a fingering pattern at the interface between the fluids, if the capillary number exceeds a critical value. This Saffman-Taylor instability is revisited for the inverse case of a viscous fluid displacing air, when partially wettable hydrophilic particles are lying on the walls. Though the inverse case is otherwise stable, the presence of the particles results in a fingering instability at low capillary number. This capillary-driven instability is driven-by the integration of particles into the interface which results from the minimization of the interfacial energy. Both axisymmetric and rectangular geometries are considered in order to quantify this phenomenon.

Published
2016
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12. Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme

Author

Zewdu, Rediet, Risolino, Maurizio, Barbulescu, Alexandru, Ramalingam, Pradeep, Butler, Jason M, and Selleri, Licia

Subjects
Zoology, Biological Sciences, Hematology, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Regenerative Medicine, Genetics, 1.1 Normal biological development and functioning, Underpinning research, Aetiology, 2.1 Biological and endogenous factors, Animals, Cytokines, Hematopoiesis, Extramedullary, Homeodomain Proteins, Mice, Mice, Knockout, Pre-B-Cell Leukemia Transcription Factor 1, Spleen, Stress, Physiological, Transcription Factors, Cxcl12/SDF-1, extramedullary hematopoiesis, GM-CSF, hematopoietic stem cells, Nkx2-5(+) spleen niche KitL/SCF, Pbx transcription factors, spleen hypoplasia, Nkx2-5+  spleen niche KitL/SCF, Biomedical Engineering, Medical Physiology, Anatomy & Morphology
Abstract

The spleen plays critical roles in immunity and also provides a permissive microenvironment for hematopoiesis. Previous studies have reported that the TALE-class homeodomain transcription factor Pbx1 is essential in hematopoietic stem and progenitor cells (HSPCs) for stem cell maintenance and progenitor expansion. However, the role of Pbx1 in the hematopoietic niche has not been investigated. Here we explored the effects that genetic perturbation of the splenic mesenchymal niche has on hematopoiesis upon loss of members of the Pbx family of homeoproteins. Splenic mesenchyme-specific inactivation of Pbx1 (SKO) on a Pbx2- or Pbx3-deficient genetic background (DKO) resulted in abnormal development of the spleen, which is dysmorphic and severely hypoplastic. This phenotype, in turn, affected the number of HSPCs in the fetal and adult spleen at steady state, as well as markedly impairing the kinetics of hematopoietic regeneration in adult mice after sub-lethal and lethal myelosuppressive irradiation. Spleens of mice with compound Pyx deficiency 8 days following sublethal irradiation displayed significant downregulation of multiple cytokine-encoding genes, including KitL/SCF, Cxcl12/SDF-1, IL-3, IL-4, GM-CSF/Csf2 IL-10, and Igf-1, compared with controls. KitL/SCF and Cxcl12/SDF-1 were recently shown to play key roles in the splenic niche in response to various haematopoietic stresses such as myeloablation, blood loss, or pregnancy. Our results demonstrate that, in addition to their intrinsic roles in HSPCs, non-cell autonomous functions of Pbx factors within the splenic niche contribute to the regulation of hematopoiesis, at least in part via the control of KitL/SCF and Cxcl12/SDF-1. Furthermore, our study establishes that abnormal spleen development and hypoplasia have deleterious effects on the efficiency of hematopoietic recovery after bone marrow injury.

Published
2016

13. A comparison of the static and dynamic properties of a semi-flexible polymer using lattice-Boltzmann and Brownian dynamics simulations

Author

Ladd, Anthony J. C., Kekre, Rahul, and Butler, Jason E.

Subjects
Physics - Computational Physics
Abstract

The aim of this paper is to compare results from lattice-Boltzmann and Brownian dynamics simulations of linear chain molecules. We have systematically varied the parameters that may affect the accuracy of the lattice-Boltzmann simulations, including grid resolution, temperature, polymer mass, and fluid viscosity. The effects of the periodic boundary conditions are minimized by an analytic correction for the different long-range interactions in periodic and unbounded systems. Lattice-Boltzmann results for the diffusion coefficient and Rouse mode relaxation times were found to be insensitive to temperature, which suggests that effects of hydrodynamic retardation are small. By increasing the resolution of the lattice-Boltzmann grid with respect to the polymer size, convergent results for the diffusion coefficient and relaxation times were obtained; these results agree with Brownian dynamics to within 1--2%., Comment: Corrected LB reduced time step ($\Delta t/t_0$) in Fig. 1 and Table 1

Published
2009
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14. The bone marrow microenvironment at single-cell resolution

Author

Tikhonova, Anastasia N., Dolgalev, Igor, Hu, Hai, Sivaraj, Kishor K., Hoxha, Edlira, Cuesta-Domínguez, Álvaro, Pinho, Sandra, Akhmetzyanova, Ilseyar, Gao, Jie, Witkowski, Matthew, Guillamot, Maria, Gutkin, Michael C., Zhang, Yutong, Marier, Christian, Diefenbach, Catherine, Kousteni, Stavroula, Heguy, Adriana, Zhong, Hua, Fooksman, David R., Butler, Jason M., Economides, Aris, Frenette, Paul S., Adams, Ralf H., Satija, Rahul, Tsirigos, Aristotelis, and Aifantis, Iannis

Published
2019
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16. Durable response after tisagenlecleucel in adults with relapsed/refractory follicular lymphoma: ELARA trial update

Author

Dreyling, Martin, Fowler, Nathan Hale, Dickinson, Michael, Martinez-Lopez, Joaquin, Kolstad, Arne, Butler, Jason, Ghosh, Monalisa, Popplewell, Leslie, Chavez, Julio C., Bachy, Emmanuel, Kato, Koji, Harigae, Hideo, Kersten, Marie José, Andreadis, Charalambos, Riedell, Peter A., Ho, P. Joy, Pérez-Simón, José Antonio, Chen, Andy I., Nastoupil, Loretta J., von Tresckow, Bastian, María Ferreri, Andrés José, Teshima, Takanori, Patten, Piers E. M., McGuirk, Joseph P., Petzer, Andreas L., Offner, Fritz, Viardot, Andreas, Zinzani, Pier Luigi, Malladi, Ram, Paule, Ines, Zia, Aiesha, Awasthi, Rakesh, Han, Xia, Germano, Davide, O’Donovan, Darragh, Ramos, Roberto, Maier, Harald J., Masood, Aisha, Thieblemont, Catherine, and Schuster, Stephen J.

Abstract

•Tisagenlecleucel responses in patients with r/r FL remain highly durable a year after primary analysis; no new safety signals were observed.•Low levels of LAG3+CD3+exhausted T cells and higher levels of naïve CD8+T cells were significantly associated with improved outcomes.

Published
2024
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18. Targeting skeletal endothelium to ameliorate bone loss

Author

Xu, Ren, Yallowitz, Alisha, Qin, An, Wu, Zhuhao, Shin, Dong Yeon, Kim, Jung-Min, Debnath, Shawon, Ji, Gang, Bostrom, Mathias P., Yang, Xu, Zhang, Chao, Dong, Han, Kermani, Pouneh, Lalani, Sarfaraz, Li, Na, Liu, Yifang, Poulos, Michael G., Wach, Amanda, Zhang, Yi, Inoue, Kazuki, Di Lorenzo, Annarita, Zhao, Baohong, Butler, Jason M., Shim, Jae-Hyuck, Glimcher, Laurie H., and Greenblatt, Matthew B.

Published
2018
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20. Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial

Author

Kennedy, Glen A, Varelias, Antiopi, Vuckovic, Slavica, Le Texier, Laetitia, Gartlan, Kate H, Zhang, Ping, Thomas, Gethin, Anderson, Lisa, Boyle, Glen, Cloonan, Nicole, Leach, Justine, Sturgeon, Elise, Avery, Judy, Olver, Stuart D, Lor, Mary, Misra, Ashish K, Hutchins, Cheryl, Morton, A James, Durrant, Simon TS, Subramoniapillai, Elango, Butler, Jason P, Curley, Cameron I, MacDonald, Kelli P A, Tey, Siok-Keen, and Hill, Geoffrey R

Published
2014
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21. Long-Term Clinical Outcomes and Correlative Efficacy Analyses in Patients (Pts) with Relapsed/Refractory Follicular Lymphoma (r/r FL) Treated with Tisagenlecleucel in the Elara Trial

Author

Dreyling, Martin, primary, Dickinson, Michael, additional, Martinez Lopez, Joaquin, additional, Kolstad, Arne, additional, Butler, Jason P, additional, Ghosh, Monalisa, additional, Popplewell, Leslie L., additional, Chavez, Julio, additional, Bachy, Emmanuel, additional, Kato, Koji, additional, Harigae, Hideo, additional, Kersten, Marie Jose, additional, Andreadis, Charalambos, additional, Riedell, Peter A., additional, Ho, Phoebe Joy, additional, Perez-Simon, Jose A., additional, Chen, Andy, additional, Nastoupil, Loretta J., additional, von Tresckow, Bastian, additional, Ferreri, Andrés J M, additional, Teshima, Takanori, additional, Patten, Piers E.M., additional, McGuirk, Joseph P., additional, Petzer, Andreas, additional, Offner, Fritz, additional, Viardot, Andreas, additional, Zinzani, Pier Luigi, additional, Malladi, Ram, additional, Paule, Ines, additional, Zia, Aiesha, additional, Awasthi, Rakesh, additional, Han, Xia, additional, Germano, Davide, additional, O'Donovan, Darragh, additional, Ramos, Roberto, additional, Masood, Aisha, additional, Thieblemont, Catherine, additional, Fowler, Nathan H., additional, and Schuster, Stephen J., additional

Published
2022
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22. A scoping review of observed benefits of Developmental Transformations (DvT)

Author

Sajnani, Nisha, Willemsen, Marc, and Butler, Jason D.

Abstract

Developmental Transformations (DvT), a practice involving interactive, improvisational play in pairs or groups, has gained international appeal as a therapeutic intervention for different populations in a variety of health, care and recreational contexts. However, a rigorous review of the benefits of DvT has not been conducted. The purpose of this study was to review extant literature for the observed benefits of DvT, identify gaps in the literature and make recommendations concerning future research including identifying possible areas for outcome measurement for preliminary studies. The authors, who each completed training in this approach, conducted a scoping review of English-language, published, peer-reviewed and grey DvT literature through 2021. From an initial 745 records retrieved through databases and a manual search, 51 publications met criteria, which, when analysed using in-vivo and pattern coding, resulted in a total of seventeen categories of observed benefits ascribed to DvT. These included six general categories – relational, emotional, social, cognitive, behavioural and physical benefits – and eleven complex categories of benefits to participants across the lifespan. In addition to benefits for participants, benefits of DvT were also observed and reported for facilitators, therapists, teachers and supervisors engaged in this practice. This review revealed inconsistencies regarding the reporting of practitioner training, frequency, format, population, intended goals, assessment measures and outcomes. Future studies with increased experimental rigor, standardized outcome measures and consistent reporting are recommended.

Published
2023
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23. Distinct bone marrow blood vessels differentially regulate haematopoiesis

Author

Itkin, Tomer, Gur-Cohen, Shiri, Spencer, Joel A., Schajnovitz, Amir, Ramasamy, Saravana K., Kusumbe, Anjali P., Ledergor, Guy, Jung, Yookyung, Milo, Idan, Poulos, Michael G., Kalinkovich, Alexander, Ludin, Aya, Golan, Karin, Khatib, Eman, Kumari, Anju, Kollet, Orit, Shakhar, Guy, Butler, Jason M., Rafii, Shahin, Adams, Ralf H., Scadden, David T., Lin, Charles P., and Lapidot, Tsvee

Published
2016
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27. Efficacy of Tisagenlecleucel in Adult Patients (Pts) with High-Risk Relapsed/Refractory Follicular Lymphoma (r/r FL): Subgroup Analysis of the Phase II Elara Study

Author

Thieblemont, Catherine, primary, Dickinson, Michael, additional, Martinez-Lopez, Joaquin, additional, Kolstad, Arne, additional, Butler, Jason P, additional, Ghosh, Monalisa, additional, Popplewell, Leslie L., additional, Chavez, Julio C., additional, Bachy, Emmanuel, additional, Kato, Koji, additional, Harigae, Hideo, additional, Kersten, Marie Jose, additional, Andreadis, Charalambos, additional, Riedell, Peter A., additional, Ho, P. Joy, additional, Pérez-Simón, Jose, additional, Chen, Andy, additional, Nastoupil, Loretta, additional, Von Tresckow, Bastian, additional, Ferreri, Andres JM, additional, Teshima, Takanori, additional, Patten, Piers EM, additional, McGuirk, Joseph P., additional, Petzer, Andreas, additional, Offner, Fritz, additional, Viardot, Andreas, additional, Zinzani, Pier Luigi, additional, Malladi, Ram, additional, Zia, Aiesha, additional, Lobetti Bodoni, C, additional, Masood, Aisha, additional, Schuster, Stephen J., additional, Fowler, Nathan H., additional, and Dreyling, Martin H., additional

Published
2021
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28. Safety Analysis of Ruxolitinib (RUX) Vs Best Available Therapy (BAT) in Patients (pts) with Steroid-Refractory (SR) Acute Graft-Vs-Host Disease (aGVHD) in the Randomized Phase 3 REACH2 Study

Author

Von Bubnoff, Nikolas, Butler, Jason P, Wagner, Eva Maria, Forcade, Edouard, Caballer, Jaime Sanz, Russo, Domenico, Grillo, Giovanni, Zuckerman, Tsila, Civriz Bozdag, Sinem, Ayuk, Francis A., Stoelzel, Friedrich, Yoon, Sung-Soo, García Gutiérrez, Jose Valentín, Ritchie, David, Bulabois, Claude-Eric, Rubio, Marie Thérèse, Xu, Judith, Morando, Juliane, Mahuzier, Bruyère, Chandraiah, Satish Mahadevaiah, and Socié, Gérard

Published
2020
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29. Efficacy and Safety of Tisagenlecleucel in Adult Patients with Relapsed/Refractory Follicular Lymphoma: Interim Analysis of the Phase 2 Elara Trial

Author

Fowler, Nathan H, Dickinson, Michael, Dreyling, Martin, Martinez-Lopez, Joaquin, Kolstad, Arne, Butler, Jason P, Ghosh, Monalisa, Popplewell, Leslie L., Chavez, Julio C., Bachy, Emmanuel, Kato, Koji, Harigae, Hideo, Kersten, Marie José, Andreadis, Charalambos, Riedell, Peter A., Ho, P. Joy, Pérez-Simón, Jose Antonio, Nagle, Sarah J., Nastoupil, Loretta J., von Tresckow, Bastian, Ferreri, Andres JM, Teshima, Takanori, Patten, Piers, McGuirk, Joseph P., Petzer, Andreas, Offner, Fritz C., Viardot, Andreas, Zinzani, Pier Luigi, Malladi, Ram, Bubuteishvili Pacaud, Lida, Forcina, Alessandra, Zia, Aiesha, Schuster, Stephen J., and Thieblemont, Catherine

Published
2020
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30. A phase 3 double-blind study of the addition of tocilizumab vs placebo to cyclosporin/methotrexate GVHD prophylaxis

Author

Kennedy, Glen A., primary, Tey, Siok-Keen, additional, Buizen, Luke, additional, Varelias, Antiopi, additional, Gartlan, Kate H., additional, Curley, Cameron, additional, Olver, Stuart D., additional, Chang, Karshing, additional, Butler, Jason P., additional, Misra, Ashish, additional, Subramoniapillai, Elango, additional, Morton, A. James, additional, Durrant, Simon, additional, Henden, Andrea S., additional, Moore, John, additional, Ritchie, David, additional, Gottlieb, David, additional, Cooney, Julian, additional, Paul, Sanjoy K., additional, and Hill, Geoffrey R., additional

Published
2021
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32. Biomarker Analysis in Patients (pts) with Steroid-Refractory Acute Graft-Vs-Host Disease (aGVHD) Treated with Ruxolitinib (RUX) or Best Available Therapy (BAT) in the Randomized, Phase 3 REACH2 Study

Author

Socié, Gérard, primary, Niederwieser, Dietger, additional, Von Bubnoff, Nikolas, additional, Mohty, Mohamad, additional, Szer, Jeffrey, additional, Or, Reuven, additional, Butler, Jason P, additional, Wagner, Eva Maria, additional, Forcade, Edouard, additional, Caballer, Jaime Sanz, additional, Russo, Domenico, additional, Grillo, Giovanni, additional, Zuckerman, Tsila, additional, Civriz Bozdag, Sinem, additional, Ritchie, David, additional, Chaturvedi, Shalini, additional, Prahallad, Anirudh, additional, Sinclair, Karen, additional, Wilke, Celine, additional, and Zeiser, Robert, additional

Published
2020
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33. Supporting Cancer Survivors Following Treatment for Non-Hodgkin's and Hodgkin's Lymphoma: A Pilot Study Assessing the Feasibility and Process Outcomes of a Nurse-Led Intervention.

Author

Spooner, Amy J., Turner, Jane, Button, Elise, Yates, Patsy, Kennedy, Glen, Butler, Jason, Bradford, Natalie, Chan, Alexandre, Hart, Nicolas H., and Chan, Raymond J.

Abstract

Lymphoma is the sixth most common cancer in Australia and comprises 2.8% of worldwide cancer diagnoses. Research targeting development and evaluation of post-treatment care for debilitating complications resulting from the disease and its treatment is limited. This study aimed to assess the feasibility and acceptability of a nurse-led survivorship intervention, post-treatment in Hodgkin's and non-Hodgkin's lymphoma survivors. A single-center, prospective, 3-arm, pilot, randomized controlled, parallel-group trial was used. People with lymphoma were recruited and randomized to the intervention (ENGAGE), education booklet only, or usual care arm. Participants receiving ENGAGE received an educational booklet and were offered 3 consultations (via various modes) with a cancer nurse to develop a survivorship care plan and healthcare goals. Participant distress and intervention acceptability was measured at baseline and 12-wk. Acceptability was measured via a satisfaction survey using a 11-point scale. Feasibility was measured using participation, retention rates, and process outcomes. Data were analyzed using descriptive statistics. Thirty-four participants with HL and NHL were recruited to the study (11 = intervention, 11 = information only, 12 = usual care). Twenty-seven participants (79%) completed all time points from baseline to 12 wk. Seven (88%) of the 8 participants receiving ENGAGE completed all consultations using various modes to communicate with the nurse (videoconference 14/23, 61%; phone 5/23, 22%; face-to-face 4/23, 17%). Participants who completed the intervention were highly satisfied with ENGAGE. The ENGAGE intervention is feasible and highly acceptable for lymphoma survivors. These findings will inform a larger trial assessing effectiveness and cost effectiveness of ENGAGE. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Results of a Phase III Double-Blind Study of the Addition of Tocilizumab Vs. Placebo to Cyclosporin/Methotrexate Gvhd Prophylaxis after HLA-Matched Allogeneic Stem Cell Transplantation

Author

Kennedy, Glen A, primary, Tey, Siok-Keen, primary, Curley, Cameron, primary, Butler, Jason P, primary, Misra, Ashish, primary, Subramoniapillai, Elango, primary, Morton, James, primary, Durrant, Simon, primary, Hendon, Andrea S, primary, Moore, John, primary, Ritchie, David, primary, Gottlieb, David, primary, Cooney, Julian, primary, Buizen, Luke, primary, Paul, Sanjoy K, primary, and Hill, Geoff R., primary

Published
2019
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35. Clinical Outcomes of Patients with Relapsed/Refractory Follicular Lymphoma Treated with Tisagenlecleucel: Phase 2 Elara 3-Year Follow-up

Author

Schuster, Stephen J., Fowler, Nathan H., Dickinson, Michael, Martinez-Lopez, Joaquin, Kolstad, Arne, Butler, Jason, Ghosh, Monalisa, Popplewell, Leslie, Chavez, Julio C., Bachy, Emmanuel, Kato, Koji, Harigae, Hideo, Kersten, Marie José, Andreadis, Charalambos, Riedell, Peter A., Ho, P Joy, Pérez-Simón, José Antonio, Chen, Andy I., Nastoupil, Loretta J., von Tresckow, Bastian, Ferreri, Andres Jose Maria, Teshima, Takanori, Patten, Piers EM, McGuirk, Joseph P., Petzer, Andreas, Offner, Fritz, Viardot, Andreas, Zinzani, Pier Luigi, Malladi, Ram, Zia, Aiesha, Awasthi, Rakesh, Paule, Ines, Germano, Davide, Ramos, Roberto, Hsu, Pei, Thieblemont, Catherine, and Dreyling, Martin

Abstract

Primary analysis of the Phase II ELARA trial (median follow-up: 17 mo) reported high response rates and a favorable safety profile in heavily pretreated patients (pts) with relapsed/refractory follicular lymphoma (r/r FL). Here we report longer-term efficacy, safety, pharmacokinetic, and exploratory biomarker analyses after a median follow-up of more than 3 y.

Published
2024
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36. High-Dose Cytarabine (HiDAC) Improves the Cure Rate of Patients with Newly Diagnosed Acute Myeloid Leukemia (AML): Is It Better to be Given As Induction Therapy or As Consolidation Therapy?

Author

Schwarer, Anthony P, primary, Wight, Joel, additional, Jackson, Kathryn, additional, Beligaswatte, Ashanka Mahilal, additional, Butler, Jason P, additional, Kennedy, Glen, additional, Martin, Louisa, additional, Lewis, Ian D., additional, Hiwase, Devendra, additional, Zantomio, Daniela, additional, He, Simon Z., additional, Grigg, Andrew, additional, Morris, Kirk, additional, Mollee, Peter, additional, and Marlton, Paula, additional

Published
2016
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39. From a distance: Technology and the first low-residency drama therapy education program

Author

Pilgrim, Kristen, Ventura, Nicole, Bingen, Amy, Faith, Emily, Fort, Juliana, Reyes, Olivia, Richmond, Mimi, Rosenthal-Schutt, Susannah, Schwinn, S. Aaron, and Butler, Jason D.

Abstract

This article examines the first-year experiences of Lesley University’s first low-residency master’s drama therapy training cohort and their advisor. Course work in this program combines predominantly online learning with several weeks of in-person learning each year, marking a departure from traditional drama therapy education. This article explores ways in which distance learning impacted this cohort in their first year of drama therapy education. Within the cohort’s reflections, specific themes related to technology, cohort experience, course instruction and work‐life balance are examined as well as drama therapy‐specific aspects of their experience. Recommendations are made for future hybrid drama therapy education, including increased use of video and video conferencing, increased training of online instructors, standard use of in-person residencies and further research into technology in drama therapy.

Published
2020
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40. Ibrutinib plus rituximab and mini-CHOP in very elderly patients with newly diagnosed DLBCL: A phase II ALLG study

Author

Verner, Emma, Johnston, Amanda, Pati, Nalini, Hawkes, Eliza A, Lee, Hui Peng, Cochrane, Tara, Cheah, Chan Yoon, Filshie, Robin, Purtill, Duncan, Sia, Hanlon, Enjeti, Anoop K, Brown, Christina, Murphy, Nicholas, Curnow, Jennifer, Lee, Kenneth, Gandhi, Maher K, Walia, Mannu, Butcher, Belinda E, Trotman, Judith, Lenton, Douglas, Taper, John, Presgrave, Peter, Butler, Jason, Mollee, Peter, Kannourakis, George, and Steer, Christopher

Abstract

•Ibrutinib-R-mini-CHOP was a deliverable combination in DLBCL patients 75 years and above•Ibrutinib-R-mini-CHOP improves PFS compared to historical rates reported for R-mini-CHOP, but this study did not demonstrate a superior OS

Published
2024
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41. Direct Comparison of the Hygroscopic Properties of Ammonium Sulfate and Sodium Chloride Aerosol at Relative Humidities Approaching Saturation

Author

Walker, Jim S., Wills, Jon B., Reid, Jonathan P., Wang, Liangyu, Topping, David O., Butler, Jason R., and Zhang, Yun-Hong

Abstract

Holographic optical tweezers are used to make comparative measurements of the hygroscopic properties of single component aqueous aerosol containing sodium chloride and ammonium sulfate over a range of relative humidity from 84% to 96%. The change in RH over the course of the experiment is monitored precisely using a sodium chloride probe droplet with accuracy better than ±0.09%. The measurements are used to assess the accuracy of thermodynamic treatments of the relationship between water activity and solute mass fraction with particular attention focused on the dilute solute limit approaching saturation vapor pressure. The consistency of the frequently used Clegg−Brimblecombe−Wexler (CBW) treatment for predicting the hygroscopic properties of sodium chloride and ammonium sulfate aerosol is confirmed. Measurements of the equilibrium size of ammonium sulfate aerosol are found to agree with predictions to within an uncertainty of ±0.2%. Given the accuracy of treating equilibrium composition, the inconsistencies highlighted in recent calibration measurements of critical supersaturations of sodium chloride and ammonium sulfate aerosol cannot be attributed to uncertainties associated with the thermodynamic predictions and must have an alternative origin. It is concluded that the CBW treatment can allow the critical supersaturation to be estimated for sodium chloride and ammonium sulfate aerosol with an accuracy of better than ±0.002% in RH. This corresponds to an uncertainty of ≤1% in the critical supersaturation for typical supersaturations of 0.2% and above. This supports the view that these systems can be used to accurately calibrate instruments that measure cloud condensation nuclei concentrations at selected supersaturations. These measurements represent the first study in which the equilibrium properties of two particles of chemically distinct composition have been compared simultaneously and directly alongside each other in the same environment.

Published
2024
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44. Derivation and characterization of a UCP1 reporter human ES cell line.

Author

Mukherjee, Suranjit, Zhang, Tuo, Lacko, Lauretta A., Tan, Lei, Xiang, Jenny Zhaoying, Butler, Jason M., and Chen, Shuibing

Abstract

Interest in human brown fat as a novel therapeutic target to tackle the growing obesity and diabetes epidemic has increased dramatically in recent years. While much insight into brown fat biology has been gained from murine cell lines and models, few resources are available to study human brown fat in vitro, which makes the need for new ways to derive and study human brown adipocytes imperative. Human ES cell based reporter systems present an excellent tool to identify, mark, and purify cell populations of choice. In this study, we detail the derivation and characterization of a novel human ES UCP1 reporter cell line that marks UCP1 positive adipocytes in vitro. We targeted a mCherry reporter to the UCP1 stop codon via CRISPR-Cas9 based gene targeting. The brown adipocytes derived from reporter cells express UCP1, display high mitochondrial content, multi-locular lipid morphology, and exhibit functional properties such as lipolysis. The mCherry positive cells purified after cell sorting show elevated expression of brown fat marker genes and a high similarity to isolated human brown fat via RNA-seq analysis. Finally, we demonstrate the utility of this reporter to real time monitor UCP1 expression upon stimulation. This reporter cell line thus presents new opportunities to study human brown fat biology by enabling future work to understand early human brown fat development, perform disease modeling, and facilitate drug screening. [ABSTRACT FROM AUTHOR]

Published
2018
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45. Pegylated interferon-2α invokes graft-versus-leukemia effects in patients relapsing after allogeneic stem cell transplantation

Author

Henden, Andrea S., Varelias, Antiopi, Leach, Justine, Sturgeon, Elise, Avery, Judy, Kelly, Jessica, Olver, Stuart, Samson, Luke, Hartel, Gunter, Durrant, Simon, Butler, Jason, Morton, Anthony J., Misra, Ashish, Tey, Siok-Keen, Subramoniapillai, Elango, Curley, Cameron, Kennedy, Glen, and Hill, Geoffrey R.

Abstract

Allogeneic stem cell transplantation (SCT) is a curative therapy for patients with hematological malignancies related largely to an immunological graft-versus-leukemia (GVL) effect mediated by donor T cells and natural killer cells. Relapse of disease after SCT represents failure of GVL and is now the major cause of treatment failure. We sought to augment GVL effects in patients (n = 29) relapsing after SCT in a prospective phase I/II clinical trial of dose-escalated pegylated interferon-2α (peg-IFNα). The administration of peg-IFNα after reinduction chemotherapy, with or without subsequent donor lymphocyte infusion (DLI), resulted in a 2-year overall survival (OS) of 31% (95% confidence interval, 17.3%-49.2%), which rejects the null hypothesis of 7% generated by observations in an institutional historical cohort. As expected, peg-IFNα was associated with graft-versus-host disease (GVHD) and hematological toxicity, which was manageable with scheduled dose modifications. Progression-free survival (PFS) was greatest in patients who experienced GVHD, although the majority of those patients still eventually progressed. Higher PFS and OS were associated with pretreatment proportions of immune cell populations with regulatory function, including mucosal invariant T cells, regulatory T cells, and plasmacytoid dendritic cells, independent of any association with GVHD. Peg-IFNα administration after relapse thus constitutes a logical strategy to invoke GVL effects and should be studied in a larger, multicenter cohort. This trial was registered at www.anzctr.org.au as #ACTRN12612000728831.

Published
2019
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46. Clinical Outcomes of Patients with Relapsed/Refractory Follicular Lymphoma Treated with Tisagenlecleucel: Phase 2 Elara 3-Year Follow-up

Author

Schuster, Stephen J, Fowler, Nathan, Dickinson, Michael, Martinez-Lopez, Joaquin, Kolstad, Arne, Butler, Jason, Ghosh, Monalisa, Popplewell, Leslie L., Chavez, Julio C, Bachy, Emmanuel, Kato, Koji, Harigae, Hideo, Kersten, Marie José, Andreadis, Charalambos, Riedell, Peter A, Ho, Phoebe Joy, Perez-Simon, Jose A., Chen, Andy, Nastoupil, Loretta J., von Tresckow, Bastian, Ferreri, Andrés José María, Teshima, Takanori, Patten, Piers, McGuirk, Joseph P, Petzer, Andreas L, Offner, Fritz, Viardot, Andreas, Zinzani, Pier Luigi, Malladi, Ram, Zia, Aiesha, Awasthi, Rakesh, Paule, Ines, Germano, Davide, Ramos, Roberto Javier, Hsu, Pei, Thieblemont, Catherine, and Dreyling, Martin

Abstract

Background: Tisagenlecleucel is approved in the United States and Europe for adults with relapsed/refractory follicular lymphoma (r/r FL) after ≥2 lines of prior therapy. The primary analysis of the Phase II ELARA trial (median follow-up: 17 months) reported high response rates and a favorable safety profile in heavily pretreated patients with r/r FL. Here we report longer-term efficacy, safety, pharmacokinetic, and exploratory biomarker analyses after a median follow-up of more than 3 years.

Published
2023
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50. The Addition Of Interleukin-6 Inhibition To Standard Gvhd Prophylaxis Prevents Acute Gvhd: Interim Results Of a Phase I/II Clinical Study

Author

Kennedy, Glen A, primary, Varelias, Antiopi, additional, Vuckovic, Slavica, additional, Zhang, Ping, additional, MacDonald, Kelli PA, additional, Leach, Justine, additional, Sturgeon, Elise, additional, Avery, Judy, additional, Olver, Stuart D, additional, Lor, Mary, additional, Hutchins, Cheryl J, additional, Morton, James A, additional, Durrant, Simon TS, additional, Misra, Ashish, additional, Subramoniapillai, Elango, additional, Butler, Jason P, additional, Curley, Cameron, additional, Tey, Siok K, additional, and Hill, Geoffrey R, additional

Published
2013
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