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97 results on '"Buttó, Ludovica"'

1. Intestinal Stem Cell Niche Defects Result in Impaired 3D Organoid Formation in Mouse Models of Crohn's Disease-like Ileitis

Author

Buttó, Ludovica F, Pelletier, Adam, More, Shyam K, Zhao, Nan, Osme, Abdullah, Hager, Christopher L, Ghannoum, Mahmoud A, Sekaly, Rafick-Pierre, Cominelli, Fabio, and Dave, Maneesh

Subjects
Biochemistry and Cell Biology, Biological Sciences, Regenerative Medicine, Stem Cell Research - Nonembryonic - Non-Human, Inflammatory Bowel Disease, Crohn's Disease, Autoimmune Disease, Stem Cell Research, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Oral and gastrointestinal, Animals, Crohn Disease, Culture Media, Conditioned, Dexamethasone, Disease Models, Animal, Gene Expression Regulation, Ileitis, Inflammation, Intestinal Mucosa, Intestine, Small, Male, Mice, Inbred C57BL, Organoids, Signal Transduction, Stem Cell Niche, Stem Cells, Tumor Necrosis Factor-alpha, Wnt3A Protein, Crohn’s disease, Paneth cells, RNAseq, SAMP1/YitFc, TNF(ΔARE), enteroids, epithelial barrier defect, intestinal stem cell niche, organoids, stem cells, Clinical Sciences, Biochemistry and cell biology
Abstract

Intestinal epithelial barrier dysfunction is a risk factor in the pathogenesis of Crohn's disease (CD); however, no corrective FDA-approved therapies exist. We used an enteroid (EnO)-based system in two murine models of experimental CD, SAMP1/YitFc (SAMP) and TNFΔARE/+ (TNF). While severely inflamed SAMP mice do not generate EnOs, "inflammation-free" SAMP mice form EnO structures with impaired morphology and reduced intestinal stem cell (ISC) and Paneth cell viability. We validated these findings in TNF mice concluding that inflammation in intestinal tissues impedes EnO generation and suppressing inflammation by steroid administration partially rescues impaired formation in SAMP mice. We generated the first high-resolution transcriptional profile of the SAMP ISC niche demonstrating that alterations in multiple key pathways contribute to niche defect and targeting them may partially rescue the phenotype. Furthermore, we correlated the defects in formation and the rescue of EnO formation to reduced viability of ISCs and Paneth cells.

Published
2020

9. Replacing Animal Protein with Soy-Pea Protein in an “American Diet” Controls Murine Crohn Disease–Like Ileitis Regardless of Firmicutes: Bacteroidetes Ratio

Author

Raffner Basson, Abigail, primary, Gomez-Nguyen, Adrian, additional, LaSalla, Alexandria, additional, Buttó, Ludovica, additional, Kulpins, Danielle, additional, Warner, Alexandra, additional, Di Martino, Luca, additional, Ponzani, Gina, additional, Osme, Abdullah, additional, Rodriguez-Palacios, Alexander, additional, and Cominelli, Fabio, additional

Published
2021
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10. Human Gut Microbiome Transplantation in Ileitis Prone Mice: A Tool for the Functional Characterization of the Microbiota in Inflammatory Bowel Disease Patients

Author

Basson, Abigail R, primary, Gomez-Nguyen, Adrian, additional, Menghini, Paola, additional, Buttó, Ludovica F, additional, Di Martino, Luca, additional, Aladyshkina, Natalia, additional, Osme, Abdullah, additional, Lasalla, Alexandria, additional, Fischer, Derek, additional, Ezeji, Jessica C, additional, Erkkila, Hailey L, additional, Brennan, Connery J, additional, Lam, Minh, additional, Rodriguez-Palacios, Alexander, additional, and Cominelli, Fabio, additional

Published
2019
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13. Human Gut Microbiome Transplantation in Ileitis Prone Mice: A Tool for the Functional Characterization of the Microbiota in Inflammatory Bowel Disease Patients.

Author

Basson, Abigail R, Gomez-Nguyen, Adrian, Menghini, Paola, Buttó, Ludovica F, Martino, Luca Di, Aladyshkina, Natalia, Osme, Abdullah, LaSalla, Alexandria, Fischer, Derek, Ezeji, Jessica C, Erkkila, Hailey L, Brennan, Connery J, Lam, Minh, Rodriguez-Palacios, Alexander, and Cominelli, Fabio

Published
2020
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14. Neutralization of IL-1a ameliorates Crohn's diseaselike ileitis by functional alterations of the gut microbiome.

Author

Menghini, Paola, Corridoni, Daniele, Buttó, Ludovica F., Osme, Abdullah, Shivaswamy, Sushma, Lam, Minh, Bamias, Giorgos, Pizarro, Theresa T., Rodriguez-Palacios, Alexander, Dinarello, Charles A., and Cominelli, Fabio

Subjects
INFLAMMATORY bowel diseases, GUT microbiome, CROHN'S disease, ILEITIS, ULCERATIVE colitis
Abstract

Crohn's disease and ulcerative colitis are chronic and progressive inflammatory bowel diseases (IBDs) that are attributed to dysregulated interactions between the gut microbiome and the intestinal mucosaassociated immune system. There are limited studies investigating the role of either IL-1α or IL-1β in mouse models of colitis, and no clinical trials blocking either IL-1 have yet to be performed. In the present study, we show that neutralization of IL-1α by a specific monoclonal antibody against murine IL-1α was highly effective in reducing inflammation and damage in SAMP mice, mice that spontaneously develop a Crohn's-like ileitis. Anti-mouse IL-1α significantly ameliorated the established, chronic ileitis and also protected mice from developing acute DSS-induced colitis. Both were associated with taxonomic divergence of the fecal gut microbiome, which was treatment-specific and not dependent on inflammation. Anti-IL-1α administration led to a decreased ratio of Proteobacteria to Bacteroidetes, decreased presence of Helicobacter species, and elevated representation of Mucispirillum schaedleri and Lactobacillus salivarius. Such modification in flora was functionally linked to the antiinflammatory effects of IL-1α neutralization, as blockade of IL-1α was not effective in germfree SAMP mice. Furthermore, preemptive dexamethasone treatment of DSS-challenged SAMP mice led to changes in flora composition without preventing the development of colitis. Thus, neutralization of IL-1α changes specific bacterial species of the intestinal microbiome, which is linked to its antiinflammatory effects. These functional findings may be of significant value for patients with IBD, who may benefit from targeted IL-1α-based therapies. [ABSTRACT FROM AUTHOR]

Published
2019
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24. World Congress Integrative Medicine & Health 2017: Part one

Author

Brinkhaus, Benno, Falkenberg, Torkel, Haramati, Aviad, Willich, Stefan N, Briggs, Josephine P, Willcox, Merlin, Linde, Klaus, Theorell, Töres, Wong, Lisa M, Dusek, Jeffrey, Wu, Darong, Eisenberg, David, Berger, Bettina, Kemper, Kathi, Schröer, Beate, Klein, Hedda, Ferreri, Rosaria, Kaplan, Gary, Matthes, Harald, Rotter, Gabriele, Schiff, Elad, Arnon, Zahi, Hahn, Eckhard, Luberto, Christina M, Martin, David, Schwarz, Silke, Tauschel, Diethard, Flower, Andrew, Gramminger, Harsha, Gupta, Hedwig H, Gupta, S. N, Kerckhoff, Annette, Kessler, Christian S, Michalsen, Andreas, Kim, Eun S, Jang, Eun H, Kim, Rana, Jan, Sae B, Mittwede, Martin, Mohme, Wiebke, Arye, Eran, Bonucci, Massimo, Saad, Bashar, Breitkreuz, Thomas, Rossi, Elio, Kebudi, Rejin, Daher, Michel, Razaq, Samaher, Gafer, Nahla, Nimri, Omar, Hablas, Mohamed, Kienle, Gunver S, Samuels, Noah, Silbermann, Michael, Bandelin, Lena, Lang, Anna-Lena, Wartner, Eva, Holtermann, Christoph, Binstock, Maxwell, Riebau, Robert, Mujkanovic, Edin, Cramer, Holger, Lauche, Romy, Michalsen, Andres, Ward, Lesley, Irnich, Dominik, Stör, Wolfram, Burnstock, Geoffrey, Schaible, Hans-Georg, Ots, Thomas, Langhorst, Jost, Sundberg, Tobias, Amarell, Catherina, Anheyer, Melanie, Eckert, Marion, Ogal, Mercedes, Schönauer, Annette, Reisenberger, Birgit, Brand, Bernhard, Anheyer, Dennis, Dobos, Gustav, Kroez, Matthias, Ammendola, Aldo, Mao, Jun J, Witt, Claudia, Yang, Yufei, Oritz, Miriam, Horneber, Markus, Voiß, Petra, Rosenstiel, Alexandra, Amarell, Catharina, Schad, Friedemann, Schläppi, Marc, Kröz, Matthias, Büssing, Arndt, Sela, Gil, Avshalomov, David, Attias, Samuel, Cotton, Sian, Jong, Miek, Jong, Mats, Scheffer, Christian, Edelhäuser, Friedrich, AlBedah, Abdullah, Lee, Myeong S, Khalil, Mohamed, Ogawa, Keiko, Motoo, Yoshiharu, Arimitsu, Junsuke, Ogawa, Masao, Shimizu, Genki, Stange, Rainer, Kraft, Karin, Kuchta, Kenny, Watanabe, Kenji, Bonin, D, Gruber, Harald, Koch, Sabine, Pohlmann, Urs, Caldwell, Christine, Krantz, Barbara, Kortum, Ria, Martin, Lily, Wieland, Lisa S, Kligler, Ben, Fogerite, Susan, Zhang, Yuqing, Riva, John J, Lumpkin, Michael, Ratner, Emily, Ping, Liu, Jian, Pei, Hamme, Gesa-Meyer, Mao, Xiaosong, Chouping, Han, Schröder, Sven, Hummelsberger, Josef, Wullinger, Michael, Brodzky, Marc, Zalpour, Christoff, Langley, Julia, Weber, Wendy, Mudd, Lanay M, Wayne, Peter, Witt, Clauda, Weidenhammer, Wolfgang, Fønnebø, Vinjar, Boon, Heather, Steel, Amie, Bugarcic, Andrea, Rangitakatu, Melisa, Adams, Jon, Sibbritt, David, Wardle, Jon, Leach, Matthew, Schloss, Janet, Dieze, Helene, Ijaz, Nadine, Heinrich, Michael, Lewith, George, Graz, Bertrand, Adam, Daniela, Grabenhenrich, Linus, Ortiz, Miriam, Binting, Sylvia, Reinhold, Thomas, Andermo, Susanne, Nordberg, Johanna H, Arman, Maria, Bhasin, Manoj, Fan, Xueyi, Libermann, Towia, Fricchione, Gregory, Denninger, John, Benson, Herbert, Martin, David D, Boers, Inge, Vlieger, Arine, Teut, Michael, Ullmann, Alexander, Lotz, Fabian, Roll, Stephanie, Canella, Claudia, Mikolasek, Michael, Rostock, Matthias, Beyer, Jörg, Guckenberger, Matthias, Jenewein, Josef, Linka, Esther, Six, Claudia, Stoll, Sarah, Stupp, Roger, Witt, Claudia M, Chuang, Elisabeth, McKee, Melissa D, Klose, Petra, Lange, Silke, Chung, Vincent C H, Wong, Hoi L C, Wu, Xin Y, Wen, Grace Y G, Ho, Robin S T, Ching, Jessica Y L, Wu, Justin C Y, Coakley, Amanda, Flanagan, Jane, Annese, Christine, Empoliti, Joanne, Gao, Zishan, Liu, Xugang, Yu, Shuguang, Yan, Xianzhong, Liang, Fanrong, Hohmann, Christoph D, Steckhan, Nico, Ostermann, Thomas, Paetow, Arion, Hoff, Evelyn, Hu, Xiao-Yang, Wu, Ruo-Han, Logue, Martin, Blonde, Clara, Lai, Lily Y, Stuart, Beth, Fei, Yu-Tong, Moore, Michael, Liu, Jian-Ping, Jeitler, Michael, Zillgen, Hannah, Högl, Manuel, Stöckigt, Barbara, Seifert, Georg, Kessler, Christian, Khadivzadeh, Talat, Bashtian, Maryam H, Aval, Shapour B, Esmaily, Habibollah, Kim, Jihye, Kim, Keun H, Klocke, Carina, Joos, Stefanie, Koshak, Abdulrahman, Wie, Li, Koshak, Emad, Wali, Siraj, Alamoudi, Omer, Demerdash, Abdulrahman, Qutub, Majdy, Pushparaj, Peter, Kruse, Sigrid, Fischer, Isabell, Tremel, Nadine, Rosenecker, Joseph, Leung, Brenda, Takeda, Wendy, Liang, Ning, Feng, Xue, Liu, Jian-ping, Cao, Hui-juan, Shinday, Nina, Philpotts, Lisa, Park, Elyse, Fricchione, Gregory L, Yeh, Gloria, Munk, Niki, Zakeresfahani, Arash, Foote, Trevor R, Ralston, Rick, Boulanger, Karen, Özbe, Dominik, Gräßel, Elmar, Luttenberger, Katharina, Pendergrass, Anna, Pach, Daniel, Strobl, Judit, Chang, Yinhui, Pasura, Laura, Liu, Bin, Jäger, Sven F, Loerch, Ronny, Jin, Li, Icke, Katja, Shi, Xuemin, Paul, Friedemann, Rütz, Michaela, Lynen, Andreas, Schömitz, Meike, Vahle, Maik, Salomon, Nir, Lang, Alon, Lahat, Adi, Kopylov, Uri, Horin, Shomron, Noi, Ofir, Avidan, Benjamin, Elyakim, Rami, Gamus, Dorit, NG, Siew, Chang, Jessica, Wu, Justin, Kaimiklotis, John, Schumann, Dania, Buttó, Ludovica, Haller, Dirk, Smith, Caroline, Lacey, Sheryl, Chapman, Michael, Ratcliffe, Julie, Johnson, Neil, Lyttleton, Jane, Boothroyd, Clare, Fahey, Paul, Tjaden, Bram, Vliet, Marja, Wietmarschen, Herman, Tröger, Wilfried, Vuolanto, Pia, Aarva, Paulina, Sorsa, Minna, Helin, Kaija, Wenzel, Claudia, Zoderer, Iris, Pammer, Patricia, Simon, Patrick, Tucek, Gerhard, Wode, Kathrin, Henriksson, Roger, Sharp, Lena, Stoltenberg, Anna, ying, Yang, Wang, Li-qiong, Li, Jin-gen, Wang, Ying, Balneaves, Lynda, Capler, Rielle, Bocci, Chiara, Guffi, Marta, Paolini, Marina, Meaglia, Ilaria, Porcu, Patrizia, Ivaldi, Giovanni B, Dragan, Simona, Bucuras, Petru, Pah, Ana M, Petrescu, Marius, Buleu, Florina, Stoichescu, Gheorghe, Christodorescu, Ruxandra, Kao, Lan, Cho, Yumin, Klafke, Nadja, Mahler, Cornelia, von Hagens, Cornelia, Uhlmann, Lorenz, Bentner, Martina, Schneeweiß, Andreas, Mueller, Andreas, Szecsenyi, Joachim, Neri, Isabella, Schnabel, Katharina, Cree, Margit, Suhr, Ralf, Baccetti, Sonia, Firenzuoli, Fabio, Monechi, Maria V, Stefano, Mariella, Amunni, Gianni, Wong, Wendy, Chen, Bingzhong, Amri, Hakima, Kotlyanskaya, Lucy, Anderson, Belinda, Evans, Roni, Marantz, Paul, Bradley, Ryan, LaForce, Cathryn, Zwickey, Heather, Kligler, Benjamin, Brooks, Audrey, Kreitzer, Mary J, Lebensohn, Patricia, Goldblatt, Elisabeth, Esmel, Neus, Herrera, Maria, Jocham, Alexandra, Berberat, Pascal O, Schneider, Antonius, Masetti, Morgana, Murakozy, Henriette, Agdal, Rita, Atarzadeh, Fatemeh, Jaladat, Amir M, Hoseini, Leila, Amini, Fatemeh, Bai, Chen, Liu, Tiegang, Zheng, Zian, Wan, Yuxiang, Xu, Jingnan, Wang, Xuan, Yu, He, Gu, Xiaohong, Daneshfard, Babak, Nimrouzi, Majid, Tafazoli, Vahid, Alorizi, Seyed M E, Saghebi, Seyed A, Fattahi, Mohammad R, Salehi, Alireza, Rezaeizadeh, Hossein, Zarshenas, Mohammad M, Fox, Kealoha, Hughes, John, Kostanjsek, Nenad, Espinosa, Stéphane, Fisher, Peter, Latif, Abdul, Lefeber, Donald, Paske, William, Öztürk, Ali Ö, Öztürk, Gizemnur, Tissing, Wim, Naafs, Marianne, Busch, Martine, Sanaye, Mohammad R, Dräger, Kilian, Leininger, Brent, Shafto, Kate, Breen, Jenny, Wüst, Ana P, Puigmartí, Carolina, Dongen, Martien, Dagnelie, Pieter, Thijs, Carel, White, Shelley, Wiesener, Solveig, Salamonsen, Anita, Stub, Trine, Abanades, Sergio, Blanco, Mar, Masllorens, Laia, Sala, Roser, Ahnoumy, Shafekah, Han, Dongwoon, He, Luzhu, Kim, Ha Y, Choi, Da, Alræk, Terje, Kristoffersen, Agnete, Sceidt, Christel, Bruset, Stig, Musial, Frauke, Saha, Felix J, Haller, Heidemarie, Azizi, Hoda, Khadem, Nayereh, Hassanzadeh, Malihe, Estiri, Nazanin, Azizi, Hamideh, Tavassoli, Fatemeh, Lotfalizadeh, Marzieh, Zabihi, Reza, Shabestari, Mahmoud M, Paeizi, Reza, Azari, Masoumeh A, Taghanaki, Hamidreza, Baars, Erik, Bruin, Anja, Ponstein, Anne, Segantini, Sergio, Voller, Fabio, Barth, Jürgen, Kern, Alexandra, Lüthi, Sebastian, Zieger, Anja, Otto, Fabius, Beccia, Ariel, Dunlap, Corina, Courneene, Brendan, Bedregal, Paula, Passi, Alvaro, Rodríguez, Alfredo, Chang, Mayling, Gutiérrez, Soledad, Beissner, Florian, Preibisch, Christine, Arau, Annemarie, Popovici, Roxana, Meissner, Karin, Beljanski, Sylvie, Belland, Laura, Reyes, Laura, Hwang, Ula, Sethe, Dominik, Hilgard, Dörte, Heusser, Peter, Bishop, Felicity, Abbadey, Miznah, Bradbury, Katherine, Carnes, Dawn, Dimitrov, Borislav, Fawkes, Carol, Foster, Jo, MacPherson, Hugh, Roberts, Lisa, Yardley, Lucy, Holmes, Michelle, Little, Paul, Cooper, Cyrus, Bogani, Patrizia, Maggini, Valentina, Gallo, Eugenia, Miceli, Elisangela, Biffi, Sauro, Mengoni, Alessio, Fani, Renato, Guendling, Nadine, Guendling, Peter W, Bronfort, Gert, Haas, Mitch, Schulz, Craig, Bu, Xiangwei, Wang, J., Fang, T., Shen, Z., He, Y., Zhang, X., Zhang, Zhengju, Wang, Dali, Meng, Fengxian, Baumann, Klaus, Frick, Eckhard, Jacobs, Christoph, Grünther, Ralph-Achim, Lötzke, Désirée, Jung, Sonny, Recchia, Daniela R, Robens, Sibylle, Stankewitz, Josephin, Jeitler, Mika, Cheon, Chunhoo, Jang, Bo H, Ko, Seong G, Huang, Ching W, Sasaki, Yui, Ko, Youme, Cheshire, Anna, Ridge, Damien, Peters, David, Panagioti, Maria, Simon, Chantal, Cho, Hyun J, Choi, Soo J, Jung, Young S, Im, Hyea B, Cooley, Kieran, Simmons, Laura, Wasson, Rachel, Kraemer, Kristen, Sears, Richard, Hueber, Carly, Derk, Gwendolyn, Lill, JR, An, Ruopeng, Steinberg, Lois, Rodriguez, Lourdes D, Fuente, Francisca G, Vega, Miguel, Román, Keyla, Ruiz, Jonatan, Villanueva, Irene, Fuente, Francisca, Guerrero, Fanny, Castillo, Noelia, Saez, Gualberto, Jimenez, José I, Gomez, Olga, Muñoz, Luis, Diez, Camino, Dicen, Demijon, Diezel, Helene, Frawley, Jane, Broom, Alex, Dong, Fei, Ma, Xueyan, Yan, Liyi, Wu, Liqun, Ma, Jiaju, Zhen, Jianhua, Dubois, Julie, Rodondi, Pierre-Yves, Schwartze, Sophia, Trapp, Barbara, Cysarz, Dirk, Brinkhaus, Benno, Falkenberg, Torkel, Haramati, Aviad, Willich, Stefan N, Briggs, Josephine P, Willcox, Merlin, Linde, Klaus, Theorell, Töres, Wong, Lisa M, Dusek, Jeffrey, Wu, Darong, Eisenberg, David, Berger, Bettina, Kemper, Kathi, Schröer, Beate, Klein, Hedda, Ferreri, Rosaria, Kaplan, Gary, Matthes, Harald, Rotter, Gabriele, Schiff, Elad, Arnon, Zahi, Hahn, Eckhard, Luberto, Christina M, Martin, David, Schwarz, Silke, Tauschel, Diethard, Flower, Andrew, Gramminger, Harsha, Gupta, Hedwig H, Gupta, S. N, Kerckhoff, Annette, Kessler, Christian S, Michalsen, Andreas, Kim, Eun S, Jang, Eun H, Kim, Rana, Jan, Sae B, Mittwede, Martin, Mohme, Wiebke, Arye, Eran, Bonucci, Massimo, Saad, Bashar, Breitkreuz, Thomas, Rossi, Elio, Kebudi, Rejin, Daher, Michel, Razaq, Samaher, Gafer, Nahla, Nimri, Omar, Hablas, Mohamed, Kienle, Gunver S, Samuels, Noah, Silbermann, Michael, Bandelin, Lena, Lang, Anna-Lena, Wartner, Eva, Holtermann, Christoph, Binstock, Maxwell, Riebau, Robert, Mujkanovic, Edin, Cramer, Holger, Lauche, Romy, Michalsen, Andres, Ward, Lesley, Irnich, Dominik, Stör, Wolfram, Burnstock, Geoffrey, Schaible, Hans-Georg, Ots, Thomas, Langhorst, Jost, Sundberg, Tobias, Amarell, Catherina, Anheyer, Melanie, Eckert, Marion, Ogal, Mercedes, Schönauer, Annette, Reisenberger, Birgit, Brand, Bernhard, Anheyer, Dennis, Dobos, Gustav, Kroez, Matthias, Ammendola, Aldo, Mao, Jun J, Witt, Claudia, Yang, Yufei, Oritz, Miriam, Horneber, Markus, Voiß, Petra, Rosenstiel, Alexandra, Amarell, Catharina, Schad, Friedemann, Schläppi, Marc, Kröz, Matthias, Büssing, Arndt, Sela, Gil, Avshalomov, David, Attias, Samuel, Cotton, Sian, Jong, Miek, Jong, Mats, Scheffer, Christian, Edelhäuser, Friedrich, AlBedah, Abdullah, Lee, Myeong S, Khalil, Mohamed, Ogawa, Keiko, Motoo, Yoshiharu, Arimitsu, Junsuke, Ogawa, Masao, Shimizu, Genki, Stange, Rainer, Kraft, Karin, Kuchta, Kenny, Watanabe, Kenji, Bonin, D, Gruber, Harald, Koch, Sabine, Pohlmann, Urs, Caldwell, Christine, Krantz, Barbara, Kortum, Ria, Martin, Lily, Wieland, Lisa S, Kligler, Ben, Fogerite, Susan, Zhang, Yuqing, Riva, John J, Lumpkin, Michael, Ratner, Emily, Ping, Liu, Jian, Pei, Hamme, Gesa-Meyer, Mao, Xiaosong, Chouping, Han, Schröder, Sven, Hummelsberger, Josef, Wullinger, Michael, Brodzky, Marc, Zalpour, Christoff, Langley, Julia, Weber, Wendy, Mudd, Lanay M, Wayne, Peter, Witt, Clauda, Weidenhammer, Wolfgang, Fønnebø, Vinjar, Boon, Heather, Steel, Amie, Bugarcic, Andrea, Rangitakatu, Melisa, Adams, Jon, Sibbritt, David, Wardle, Jon, Leach, Matthew, Schloss, Janet, Dieze, Helene, Ijaz, Nadine, Heinrich, Michael, Lewith, George, Graz, Bertrand, Adam, Daniela, Grabenhenrich, Linus, Ortiz, Miriam, Binting, Sylvia, Reinhold, Thomas, Andermo, Susanne, Nordberg, Johanna H, Arman, Maria, Bhasin, Manoj, Fan, Xueyi, Libermann, Towia, Fricchione, Gregory, Denninger, John, Benson, Herbert, Martin, David D, Boers, Inge, Vlieger, Arine, Teut, Michael, Ullmann, Alexander, Lotz, Fabian, Roll, Stephanie, Canella, Claudia, Mikolasek, Michael, Rostock, Matthias, Beyer, Jörg, Guckenberger, Matthias, Jenewein, Josef, Linka, Esther, Six, Claudia, Stoll, Sarah, Stupp, Roger, Witt, Claudia M, Chuang, Elisabeth, McKee, Melissa D, Klose, Petra, Lange, Silke, Chung, Vincent C H, Wong, Hoi L C, Wu, Xin Y, Wen, Grace Y G, Ho, Robin S T, Ching, Jessica Y L, Wu, Justin C Y, Coakley, Amanda, Flanagan, Jane, Annese, Christine, Empoliti, Joanne, Gao, Zishan, Liu, Xugang, Yu, Shuguang, Yan, Xianzhong, Liang, Fanrong, Hohmann, Christoph D, Steckhan, Nico, Ostermann, Thomas, Paetow, Arion, Hoff, Evelyn, Hu, Xiao-Yang, Wu, Ruo-Han, Logue, Martin, Blonde, Clara, Lai, Lily Y, Stuart, Beth, Fei, Yu-Tong, Moore, Michael, Liu, Jian-Ping, Jeitler, Michael, Zillgen, Hannah, Högl, Manuel, Stöckigt, Barbara, Seifert, Georg, Kessler, Christian, Khadivzadeh, Talat, Bashtian, Maryam H, Aval, Shapour B, Esmaily, Habibollah, Kim, Jihye, Kim, Keun H, Klocke, Carina, Joos, Stefanie, Koshak, Abdulrahman, Wie, Li, Koshak, Emad, Wali, Siraj, Alamoudi, Omer, Demerdash, Abdulrahman, Qutub, Majdy, Pushparaj, Peter, Kruse, Sigrid, Fischer, Isabell, Tremel, Nadine, Rosenecker, Joseph, Leung, Brenda, Takeda, Wendy, Liang, Ning, Feng, Xue, Liu, Jian-ping, Cao, Hui-juan, Shinday, Nina, Philpotts, Lisa, Park, Elyse, Fricchione, Gregory L, Yeh, Gloria, Munk, Niki, Zakeresfahani, Arash, Foote, Trevor R, Ralston, Rick, Boulanger, Karen, Özbe, Dominik, Gräßel, Elmar, Luttenberger, Katharina, Pendergrass, Anna, Pach, Daniel, Strobl, Judit, Chang, Yinhui, Pasura, Laura, Liu, Bin, Jäger, Sven F, Loerch, Ronny, Jin, Li, Icke, Katja, Shi, Xuemin, Paul, Friedemann, Rütz, Michaela, Lynen, Andreas, Schömitz, Meike, Vahle, Maik, Salomon, Nir, Lang, Alon, Lahat, Adi, Kopylov, Uri, Horin, Shomron, Noi, Ofir, Avidan, Benjamin, Elyakim, Rami, Gamus, Dorit, NG, Siew, Chang, Jessica, Wu, Justin, Kaimiklotis, John, Schumann, Dania, Buttó, Ludovica, Haller, Dirk, Smith, Caroline, Lacey, Sheryl, Chapman, Michael, Ratcliffe, Julie, Johnson, Neil, Lyttleton, Jane, Boothroyd, Clare, Fahey, Paul, Tjaden, Bram, Vliet, Marja, Wietmarschen, Herman, Tröger, Wilfried, Vuolanto, Pia, Aarva, Paulina, Sorsa, Minna, Helin, Kaija, Wenzel, Claudia, Zoderer, Iris, Pammer, Patricia, Simon, Patrick, Tucek, Gerhard, Wode, Kathrin, Henriksson, Roger, Sharp, Lena, Stoltenberg, Anna, ying, Yang, Wang, Li-qiong, Li, Jin-gen, Wang, Ying, Balneaves, Lynda, Capler, Rielle, Bocci, Chiara, Guffi, Marta, Paolini, Marina, Meaglia, Ilaria, Porcu, Patrizia, Ivaldi, Giovanni B, Dragan, Simona, Bucuras, Petru, Pah, Ana M, Petrescu, Marius, Buleu, Florina, Stoichescu, Gheorghe, Christodorescu, Ruxandra, Kao, Lan, Cho, Yumin, Klafke, Nadja, Mahler, Cornelia, von Hagens, Cornelia, Uhlmann, Lorenz, Bentner, Martina, Schneeweiß, Andreas, Mueller, Andreas, Szecsenyi, Joachim, Neri, Isabella, Schnabel, Katharina, Cree, Margit, Suhr, Ralf, Baccetti, Sonia, Firenzuoli, Fabio, Monechi, Maria V, Stefano, Mariella, Amunni, Gianni, Wong, Wendy, Chen, Bingzhong, Amri, Hakima, Kotlyanskaya, Lucy, Anderson, Belinda, Evans, Roni, Marantz, Paul, Bradley, Ryan, LaForce, Cathryn, Zwickey, Heather, Kligler, Benjamin, Brooks, Audrey, Kreitzer, Mary J, Lebensohn, Patricia, Goldblatt, Elisabeth, Esmel, Neus, Herrera, Maria, Jocham, Alexandra, Berberat, Pascal O, Schneider, Antonius, Masetti, Morgana, Murakozy, Henriette, Agdal, Rita, Atarzadeh, Fatemeh, Jaladat, Amir M, Hoseini, Leila, Amini, Fatemeh, Bai, Chen, Liu, Tiegang, Zheng, Zian, Wan, Yuxiang, Xu, Jingnan, Wang, Xuan, Yu, He, Gu, Xiaohong, Daneshfard, Babak, Nimrouzi, Majid, Tafazoli, Vahid, Alorizi, Seyed M E, Saghebi, Seyed A, Fattahi, Mohammad R, Salehi, Alireza, Rezaeizadeh, Hossein, Zarshenas, Mohammad M, Fox, Kealoha, Hughes, John, Kostanjsek, Nenad, Espinosa, Stéphane, Fisher, Peter, Latif, Abdul, Lefeber, Donald, Paske, William, Öztürk, Ali Ö, Öztürk, Gizemnur, Tissing, Wim, Naafs, Marianne, Busch, Martine, Sanaye, Mohammad R, Dräger, Kilian, Leininger, Brent, Shafto, Kate, Breen, Jenny, Wüst, Ana P, Puigmartí, Carolina, Dongen, Martien, Dagnelie, Pieter, Thijs, Carel, White, Shelley, Wiesener, Solveig, Salamonsen, Anita, Stub, Trine, Abanades, Sergio, Blanco, Mar, Masllorens, Laia, Sala, Roser, Ahnoumy, Shafekah, Han, Dongwoon, He, Luzhu, Kim, Ha Y, Choi, Da, Alræk, Terje, Kristoffersen, Agnete, Sceidt, Christel, Bruset, Stig, Musial, Frauke, Saha, Felix J, Haller, Heidemarie, Azizi, Hoda, Khadem, Nayereh, Hassanzadeh, Malihe, Estiri, Nazanin, Azizi, Hamideh, Tavassoli, Fatemeh, Lotfalizadeh, Marzieh, Zabihi, Reza, Shabestari, Mahmoud M, Paeizi, Reza, Azari, Masoumeh A, Taghanaki, Hamidreza, Baars, Erik, Bruin, Anja, Ponstein, Anne, Segantini, Sergio, Voller, Fabio, Barth, Jürgen, Kern, Alexandra, Lüthi, Sebastian, Zieger, Anja, Otto, Fabius, Beccia, Ariel, Dunlap, Corina, Courneene, Brendan, Bedregal, Paula, Passi, Alvaro, Rodríguez, Alfredo, Chang, Mayling, Gutiérrez, Soledad, Beissner, Florian, Preibisch, Christine, Arau, Annemarie, Popovici, Roxana, Meissner, Karin, Beljanski, Sylvie, Belland, Laura, Reyes, Laura, Hwang, Ula, Sethe, Dominik, Hilgard, Dörte, Heusser, Peter, Bishop, Felicity, Abbadey, Miznah, Bradbury, Katherine, Carnes, Dawn, Dimitrov, Borislav, Fawkes, Carol, Foster, Jo, MacPherson, Hugh, Roberts, Lisa, Yardley, Lucy, Holmes, Michelle, Little, Paul, Cooper, Cyrus, Bogani, Patrizia, Maggini, Valentina, Gallo, Eugenia, Miceli, Elisangela, Biffi, Sauro, Mengoni, Alessio, Fani, Renato, Guendling, Nadine, Guendling, Peter W, Bronfort, Gert, Haas, Mitch, Schulz, Craig, Bu, Xiangwei, Wang, J., Fang, T., Shen, Z., He, Y., Zhang, X., Zhang, Zhengju, Wang, Dali, Meng, Fengxian, Baumann, Klaus, Frick, Eckhard, Jacobs, Christoph, Grünther, Ralph-Achim, Lötzke, Désirée, Jung, Sonny, Recchia, Daniela R, Robens, Sibylle, Stankewitz, Josephin, Jeitler, Mika, Cheon, Chunhoo, Jang, Bo H, Ko, Seong G, Huang, Ching W, Sasaki, Yui, Ko, Youme, Cheshire, Anna, Ridge, Damien, Peters, David, Panagioti, Maria, Simon, Chantal, Cho, Hyun J, Choi, Soo J, Jung, Young S, Im, Hyea B, Cooley, Kieran, Simmons, Laura, Wasson, Rachel, Kraemer, Kristen, Sears, Richard, Hueber, Carly, Derk, Gwendolyn, Lill, JR, An, Ruopeng, Steinberg, Lois, Rodriguez, Lourdes D, Fuente, Francisca G, Vega, Miguel, Román, Keyla, Ruiz, Jonatan, Villanueva, Irene, Fuente, Francisca, Guerrero, Fanny, Castillo, Noelia, Saez, Gualberto, Jimenez, José I, Gomez, Olga, Muñoz, Luis, Diez, Camino, Dicen, Demijon, Diezel, Helene, Frawley, Jane, Broom, Alex, Dong, Fei, Ma, Xueyan, Yan, Liyi, Wu, Liqun, Ma, Jiaju, Zhen, Jianhua, Dubois, Julie, Rodondi, Pierre-Yves, Schwartze, Sophia, Trapp, Barbara, and Cysarz, Dirk

Published
2017
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28. World Congress Integrative Medicine & Health 2017: Part one

Author

Brinkhaus, Benno, primary, Falkenberg, Torkel, additional, Haramati, Aviad, additional, Willich, Stefan N., additional, Briggs, Josephine P., additional, Willcox, Merlin, additional, Linde, Klaus, additional, Theorell, Töres, additional, Wong, Lisa M., additional, Dusek, Jeffrey, additional, Wu, Darong, additional, Eisenberg, David, additional, Berger, Bettina, additional, Kemper, Kathi, additional, Stock-Schröer, Beate, additional, Sützl-Klein, Hedda, additional, Ferreri, Rosaria, additional, Kaplan, Gary, additional, Matthes, Harald, additional, Rotter, Gabriele, additional, Schiff, Elad, additional, Arnon, Zahi, additional, Hahn, Eckhard, additional, Luberto, Christina M., additional, Martin, David, additional, Schwarz, Silke, additional, Tauschel, Diethard, additional, Flower, Andrew, additional, Gramminger, Harsha, additional, Gupta, Hedwig H., additional, Gupta, S. N., additional, Kerckhoff, Annette, additional, Kessler, Christian S., additional, Michalsen, Andreas, additional, Kim, Eun S., additional, Jang, Eun H., additional, Kim, Rana, additional, Jan, Sae B., additional, Mittwede, Martin, additional, Mohme, Wiebke, additional, Ben-Arye, Eran, additional, Bonucci, Massimo, additional, Saad, Bashar, additional, Breitkreuz, Thomas, additional, Rossi, Elio, additional, Kebudi, Rejin, additional, Daher, Michel, additional, Razaq, Samaher, additional, Gafer, Nahla, additional, Nimri, Omar, additional, Hablas, Mohamed, additional, Kienle, Gunver Sophia, additional, Samuels, Noah, additional, Silbermann, Michael, additional, Bandelin, Lena, additional, Lang, Anna-Lena, additional, Wartner, Eva, additional, Holtermann, Christoph, additional, Binstock, Maxwell, additional, Riebau, Robert, additional, Mujkanovic, Edin, additional, Cramer, Holger, additional, Lauche, Romy, additional, Michalsen, Andres, additional, Ward, Lesley, additional, Irnich, Dominik, additional, Stör, Wolfram, additional, Burnstock, Geoffrey, additional, Schaible, Hans-Georg, additional, Ots, Thomas, additional, Langhorst, Jost, additional, Sundberg, Tobias, additional, Amarell, Catherina, additional, Anheyer, Melanie, additional, Eckert, Marion, additional, Ogal, Mercedes, additional, Schönauer, Annette, additional, Reisenberger, Birgit, additional, Brand, Bernhard, additional, Anheyer, Dennis, additional, Dobos, Gustav, additional, Kroez, Matthias, additional, Ammendola, Aldo, additional, Mao, Jun J., additional, Witt, Claudia, additional, Yang, Yufei, additional, Oritz, Miriam, additional, Horneber, Markus, additional, Voiß, Petra, additional, von Rosenstiel, Alexandra, additional, Amarell, Catharina, additional, Schad, Friedemann, additional, Schläppi, Marc, additional, Kröz, Matthias, additional, Büssing, Arndt, additional, Bar-Sela, Gil, additional, Avshalomov, David, additional, Attias, Samuel, additional, Brinkhaus, Benno, additional, Cotton, Sian, additional, Jong, Miek, additional, Jong, Mats, additional, Scheffer, Christian, additional, Edelhäuser, Friedrich, additional, AlBedah, Abdullah, additional, Lee, Myeong Soo, additional, Khalil, Mohamed, additional, Ogawa, Keiko, additional, Motoo, Yoshiharu, additional, Arimitsu, Junsuke, additional, Ogawa, Masao, additional, Shimizu, Genki, additional, Stange, Rainer, additional, Kraft, Karin, additional, Kuchta, Kenny, additional, Watanabe, Kenji, additional, Bonin, D, additional, Gruber, Harald, additional, Koch, Sabine, additional, Pohlmann, Urs, additional, Caldwell, Christine, additional, Krantz, Barbara, additional, Kortum, Ria, additional, Martin, Lily, additional, Wieland, Lisa S., additional, Kligler, Ben, additional, Gould-Fogerite, Susan, additional, Zhang, Yuqing, additional, Riva, John J., additional, Lumpkin, Michael, additional, Ratner, Emily, additional, Ping, Liu, additional, Jian, Pei, additional, Hamme, Gesa-Meyer, additional, Mao, Xiaosong, additional, Chouping, Han, additional, Schröder, Sven, additional, Hummelsberger, Josef, additional, Wullinger, Michael, additional, Brodzky, Marc, additional, Zalpour, Christoff, additional, Langley, Julia, additional, Weber, Wendy, additional, Mudd, Lanay M., additional, Wayne, Peter, additional, Witt, Clauda, additional, Weidenhammer, Wolfgang, additional, Fønnebø, Vinjar, additional, Boon, Heather, additional, Steel, Amie, additional, Bugarcic, Andrea, additional, Rangitakatu, Melisa, additional, Adams, Jon, additional, Sibbritt, David, additional, Wardle, Jon, additional, Leach, Matthew, additional, Schloss, Janet, additional, Dieze, Helene, additional, Ijaz, Nadine, additional, Heinrich, Michael, additional, Lewith, George, additional, Graz, Bertrand, additional, Adam, Daniela, additional, Grabenhenrich, Linus, additional, Ortiz, Miriam, additional, Binting, Sylvia, additional, Reinhold, Thomas, additional, Andermo, Susanne, additional, Nordberg, Johanna Hök, additional, Arman, Maria, additional, Bhasin, Manoj, additional, Fan, Xueyi, additional, Libermann, Towia, additional, Fricchione, Gregory, additional, Denninger, John, additional, Benson, Herbert, additional, Martin, David D., additional, Boers, Inge, additional, Vlieger, Arine, additional, Teut, Michael, additional, Ullmann, Alexander, additional, Lotz, Fabian, additional, Roll, Stephanie, additional, Canella, Claudia, additional, Mikolasek, Michael, additional, Rostock, Matthias, additional, Beyer, Jörg, additional, Guckenberger, Matthias, additional, Jenewein, Josef, additional, Linka, Esther, additional, Six, Claudia, additional, Stoll, Sarah, additional, Stupp, Roger, additional, Witt, Claudia M., additional, Chuang, Elisabeth, additional, McKee, Melissa D., additional, Klose, Petra, additional, Lange, Silke, additional, Chung, Vincent C. H., additional, Wong, Hoi L. C., additional, Wu, Xin Y., additional, Wen, Grace Y. G., additional, Ho, Robin S. T., additional, Ching, Jessica Y. L., additional, Wu, Justin C. Y., additional, Coakley, Amanda, additional, Flanagan, Jane, additional, Annese, Christine, additional, Empoliti, Joanne, additional, Gao, Zishan, additional, Liu, Xugang, additional, Yu, Shuguang, additional, Yan, Xianzhong, additional, Liang, Fanrong, additional, Hohmann, Christoph D., additional, Steckhan, Nico, additional, Ostermann, Thomas, additional, Paetow, Arion, additional, Hoff, Evelyn, additional, Hu, Xiao-Yang, additional, Wu, Ruo-Han, additional, Logue, Martin, additional, Blonde, Clara, additional, Lai, Lily Y., additional, Stuart, Beth, additional, Fei, Yu-Tong, additional, Moore, Michael, additional, Liu, Jian-Ping, additional, Jeitler, Michael, additional, Zillgen, Hannah, additional, Högl, Manuel, additional, Stöckigt, Barbara, additional, Seifert, Georg, additional, Kessler, Christian, additional, Khadivzadeh, Talat, additional, Bashtian, Maryam Hassanzadeh, additional, Aval, Shapour Badiee, additional, Esmaily, Habibollah, additional, Kim, Jihye, additional, Kim, Keun H., additional, Klocke, Carina, additional, Joos, Stefanie, additional, Koshak, Abdulrahman, additional, Wie, Li, additional, Koshak, Emad, additional, Wali, Siraj, additional, Alamoudi, Omer, additional, Demerdash, Abdulrahman, additional, Qutub, Majdy, additional, Pushparaj, Peter, additional, Kruse, Sigrid, additional, Fischer, Isabell, additional, Tremel, Nadine, additional, Rosenecker, Joseph, additional, Leung, Brenda, additional, Takeda, Wendy, additional, Liang, Ning, additional, Feng, Xue, additional, Liu, Jian-ping, additional, Cao, Hui-juan, additional, Shinday, Nina, additional, Philpotts, Lisa, additional, Park, Elyse, additional, Fricchione, Gregory L., additional, Yeh, Gloria, additional, Munk, Niki, additional, Zakeresfahani, Arash, additional, Foote, Trevor R., additional, Ralston, Rick, additional, Boulanger, Karen, additional, Özbe, Dominik, additional, Gräßel, Elmar, additional, Luttenberger, Katharina, additional, Pendergrass, Anna, additional, Pach, Daniel, additional, Bellmann-Strobl, Judit, additional, Chang, Yinhui, additional, Pasura, Laura, additional, Liu, Bin, additional, Jäger, Sven F., additional, Loerch, Ronny, additional, Jin, Li, additional, Icke, Katja, additional, Shi, Xuemin, additional, Paul, Friedemann, additional, Rütz, Michaela, additional, Lynen, Andreas, additional, Schömitz, Meike, additional, Vahle, Maik, additional, Salomon, Nir, additional, Lang, Alon, additional, Lahat, Adi, additional, Kopylov, Uri, additional, Ben-Horin, Shomron, additional, Har-Noi, Ofir, additional, Avidan, Benjamin, additional, Elyakim, Rami, additional, Gamus, Dorit, additional, NG, Siew, additional, Chang, Jessica, additional, Wu, Justin, additional, Kaimiklotis, John, additional, Schumann, Dania, additional, Buttó, Ludovica, additional, Haller, Dirk, additional, Smith, Caroline, additional, de Lacey, Sheryl, additional, Chapman, Michael, additional, Ratcliffe, Julie, additional, Johnson, Neil, additional, Lyttleton, Jane, additional, Boothroyd, Clare, additional, Fahey, Paul, additional, Tjaden, Bram, additional, van Vliet, Marja, additional, van Wietmarschen, Herman, additional, Tröger, Wilfried, additional, Vuolanto, Pia, additional, Aarva, Paulina, additional, Sorsa, Minna, additional, Helin, Kaija, additional, Wenzel, Claudia, additional, Zoderer, Iris, additional, Pammer, Patricia, additional, Simon, Patrick, additional, Tucek, Gerhard, additional, Wode, Kathrin, additional, Henriksson, Roger, additional, Sharp, Lena, additional, Stoltenberg, Anna, additional, Xiao-ying, Yang, additional, Wang, Li-qiong, additional, Li, Jin-gen, additional, Wang, Ying, additional, Balneaves, Lynda, additional, Capler, Rielle, additional, Bocci, Chiara, additional, Guffi, Marta, additional, Paolini, Marina, additional, Meaglia, Ilaria, additional, Porcu, Patrizia, additional, Ivaldi, Giovanni B., additional, Dragan, Simona, additional, Bucuras, Petru, additional, Pah, Ana M., additional, Badalica-Petrescu, Marius, additional, Buleu, Florina, additional, Hogea-Stoichescu, Gheorghe, additional, Christodorescu, Ruxandra, additional, Kao, Lan, additional, Cho, Yumin, additional, Klafke, Nadja, additional, Mahler, Cornelia, additional, von Hagens, Cornelia, additional, Uhlmann, Lorenz, additional, Bentner, Martina, additional, Schneeweiss, Andreas, additional, Mueller, Andreas, additional, Szecsenyi, Joachim, additional, Neri, Isabella, additional, Schnabel, Katharina, additional, Cree, Margit, additional, Suhr, Ralf, additional, Baccetti, Sonia, additional, Firenzuoli, Fabio, additional, Monechi, Maria V., additional, Di Stefano, Mariella, additional, Amunni, Gianni, additional, Wong, Wendy, additional, Chen, Bingzhong, additional, Amri, Hakima, additional, Kotlyanskaya, Lucy, additional, Anderson, Belinda, additional, Evans, Roni, additional, Marantz, Paul, additional, Bradley, Ryan, additional, Booth-LaForce, Cathryn, additional, Zwickey, Heather, additional, Kligler, Benjamin, additional, Brooks, Audrey, additional, Kreitzer, Mary J., additional, Lebensohn, Patricia, additional, Goldblatt, Elisabeth, additional, Esmel-Esmel, Neus, additional, Jiménez-Herrera, Maria, additional, Jocham, Alexandra, additional, Berberat, Pascal O., additional, Schneider, Antonius, additional, Masetti, Morgana, additional, Murakozy, Henriette, additional, Van Vliet, Marja, additional, Agdal, Rita, additional, Atarzadeh, Fatemeh, additional, Jaladat, Amir M., additional, Hoseini, Leila, additional, Amini, Fatemeh, additional, Bai, Chen, additional, Liu, Tiegang, additional, Zheng, Zian, additional, Wan, Yuxiang, additional, Xu, Jingnan, additional, Wang, Xuan, additional, Yu, He, additional, Gu, Xiaohong, additional, Daneshfard, Babak, additional, Nimrouzi, Majid, additional, Tafazoli, Vahid, additional, Alorizi, Seyed M. Emami, additional, Saghebi, Seyed A., additional, Fattahi, Mohammad R., additional, Salehi, Alireza, additional, Rezaeizadeh, Hossein, additional, Zarshenas, Mohammad M., additional, Fox, Kealoha, additional, Hughes, John, additional, Kostanjsek, Nenad, additional, Espinosa, Stéphane, additional, Fisher, Peter, additional, Latif, Abdul, additional, Lefeber, Donald, additional, Paske, William, additional, Öztürk, Ali Ö., additional, Öztürk, Gizemnur, additional, Tissing, Wim, additional, Naafs, Marianne, additional, Busch, Martine, additional, Sanaye, Mohammad R., additional, Dräger, Kilian, additional, Leininger, Brent, additional, Shafto, Kate, additional, Breen, Jenny, additional, Simões-Wüst, Ana P., additional, Moltó-Puigmartí, Carolina, additional, van Dongen, Martien, additional, Dagnelie, Pieter, additional, Thijs, Carel, additional, White, Shelley, additional, Wiesener, Solveig, additional, Salamonsen, Anita, additional, Stub, Trine, additional, Abanades, Sergio, additional, Blanco, Mar, additional, Masllorens, Laia, additional, Sala, Roser, additional, Al-Ahnoumy, Shafekah, additional, Han, Dongwoon, additional, He, Luzhu, additional, Kim, Ha Yun, additional, In Choi, Da, additional, Alræk, Terje, additional, Kristoffersen, Agnete, additional, von Sceidt, Christel, additional, Bruset, Stig, additional, Musial, Frauke, additional, Saha, Felix J., additional, Haller, Heidemarie, additional, Azizi, Hoda, additional, Khadem, Nayereh, additional, Hassanzadeh, Malihe, additional, Estiri, Nazanin, additional, Azizi, Hamideh, additional, Tavassoli, Fatemeh, additional, Lotfalizadeh, Marzieh, additional, Zabihi, Reza, additional, Shabestari, Mahmoud Mohammadzadeh, additional, Paeizi, Reza, additional, Azari, Masoumeh Alvandi, additional, Bahrami-Taghanaki, Hamidreza, additional, Baars, Erik, additional, De Bruin, Anja, additional, Ponstein, Anne, additional, Segantini, Sergio, additional, Monechi, Maria Valeria, additional, Voller, Fabio, additional, Barth, Jürgen, additional, Kern, Alexandra, additional, Lüthi, Sebastian, additional, Zieger, Anja, additional, Otto, Fabius, additional, Beccia, Ariel, additional, Dunlap, Corina, additional, Courneene, Brendan, additional, Bedregal, Paula, additional, Passi, Alvaro, additional, Rodríguez, Alfredo, additional, Chang, Mayling, additional, Gutiérrez, Soledad, additional, Beissner, Florian, additional, Preibisch, Christine, additional, Schweizer-Arau, Annemarie, additional, Popovici, Roxana, additional, Meissner, Karin, additional, Beljanski, Sylvie, additional, Belland, Laura, additional, Rivera-Reyes, Laura, additional, Hwang, Ula, additional, Sethe, Dominik, additional, Hilgard, Dörte, additional, Heusser, Peter, additional, Bishop, Felicity, additional, Al-Abbadey, Miznah, additional, Bradbury, Katherine, additional, Carnes, Dawn, additional, Dimitrov, Borislav, additional, Fawkes, Carol, additional, Foster, Jo, additional, MacPherson, Hugh, additional, Roberts, Lisa, additional, Yardley, Lucy, additional, Holmes, Michelle, additional, Little, Paul, additional, Cooper, Cyrus, additional, Bogani, Patrizia, additional, Maggini, Valentina, additional, Gallo, Eugenia, additional, Miceli, Elisangela, additional, Biffi, Sauro, additional, Mengoni, Alessio, additional, Fani, Renato, additional, Brands-Guendling, Nadine, additional, Guendling, Peter W., additional, Bronfort, Gert, additional, Haas, Mitch, additional, Schulz, Craig, additional, Bu, Xiangwei, additional, Wang, J., additional, Fang, T., additional, Shen, Z., additional, He, Y., additional, Zhang, X., additional, Zhang, Zhengju, additional, Wang, Dali, additional, Meng, Fengxian, additional, Baumann, Klaus, additional, Frick, Eckhard, additional, Jacobs, Christoph, additional, Grünther, Ralph-Achim, additional, Lötzke, Désirée, additional, Jung, Sonny, additional, Recchia, Daniela R., additional, Robens, Sibylle, additional, Stankewitz, Josephin, additional, Jeitler, Mika, additional, Cheon, Chunhoo, additional, Jang, Bo H., additional, Ko, Seong G., additional, Huang, Ching W., additional, Sasaki, Yui, additional, Ko, Youme, additional, Cheshire, Anna, additional, Ridge, Damien, additional, Peters, David, additional, Panagioti, Maria, additional, Simon, Chantal, additional, Cho, Hyun J., additional, Choi, Soo J., additional, Jung, Young S., additional, Im, Hyea B, additional, Cooley, Kieran, additional, Tummon-Simmons, Laura, additional, Wasson, Rachel, additional, Kraemer, Kristen, additional, Sears, Richard, additional, Hueber, Carly, additional, Derk, Gwendolyn, additional, Lill, JR, additional, An, Ruopeng, additional, Steinberg, Lois, additional, Rodriguez, Lourdes Diaz, additional, la Fuente, Francisca García-de, additional, De la Vega, Miguel, additional, Vargas-Román, Keyla, additional, Fernández-Ruiz, Jonatan, additional, Cantarero-Villanueva, Irene, additional, García-De la Fuente, Francisca, additional, Jiménez-Guerrero, Fanny, additional, Galiano-Castillo, Noelia, additional, Diaz-Saez, Gualberto, additional, Torres-Jimenez, José I., additional, Garcia-Gomez, Olga, additional, Hortal-Muñoz, Luis, additional, Diaz-Diez, Camino, additional, Dicen, Demijon, additional, Diezel, Helene, additional, Frawley, Jane, additional, Broom, Alex, additional, Dong, Fei, additional, Ma, Xueyan, additional, Yan, Liyi, additional, Wu, Liqun, additional, Ma, Jiaju, additional, Zhen, Jianhua, additional, Dubois, Julie, additional, Rodondi, Pierre-Yves, additional, Schwartze, Sophia, additional, Trapp, Barbara, additional, and Cysarz, Dirk, additional

Published
2017
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32. Mechanisms of Microbe–Host Interaction in Crohn’s Disease: Dysbiosis vs. Pathobiont Selection

Author

Buttó, Ludovica F., Schaubeck, Monika, and Haller, Dirk

Subjects
Crohn’s disease, Immunology, IBD, TNF, microbiota, IEC, dysbiosis, barrier dysfunction, Paneth cells
Abstract

Crohn’s disease (CD) is a systemic chronic inflammatory condition mainly characterized by discontinuous transmural pathology of the gastrointestinal tract and frequent extraintestinal manifestations with intermittent episodes of remission and relapse. Genome-wide association studies identified a number of risk loci that, catalyzed by environmental triggers, result in the loss of tolerance toward commensal bacteria based on dysregulated innate effector functions and antimicrobial defense, leading to exacerbated adaptive immune responses responsible for chronic immune-mediated tissue damage. In this review, we discuss the inter-related role of changes in the intestinal microbiota, epithelial barrier integrity, and immune cell functions on the pathogenesis of CD, describing the current approaches available to investigate the molecular mechanisms underlying the disease. Substantial effort has been dedicated to define disease-associated changes in the intestinal microbiota (dysbiosis) and to link pathobionts to the etiology of inflammatory bowel diseases. A cogent definition of dysbiosis is lacking, as well as an agreement of whether pathobionts or complex shifts in the microbiota trigger inflammation in the host. Among the rarely available animal models, SAMP/Yit and TNFdeltaARE mice are the best known displaying a transmural CD-like phenotype. New hypothesis-driven mouse models, e.g., epithelial-specific Caspase8−/−, ATG16L1−/−, and XBP1−/− mice, validate pathway-focused function of specific CD-associated risk genes highlighting the role of Paneth cells in antimicrobial defense. To study the causal role of bacteria in initiating inflammation in the host, the use of germ-free mouse models is indispensable. Unraveling the interactions of genes, immune cells and microbes constitute a criterion for the development of safe, reliable, and effective treatment options for CD.

Published
2015
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49. Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response.

Author

Kavanaugh, Devon W., O’Callaghan, John, Buttó, Ludovica F., Slattery, Helen, Lane, Jonathan, Clyne, Marguerite, Kane, Marian, Joshi, Lokesh, and Hickey, Rita M.

Subjects
BIFIDOBACTERIUM longum, OLIGOSACCHARIDES, CELL adhesion, EPITHELIAL cells, GENETIC transcription, BACTERIAL growth, PREBIOTICS
Abstract

In this study, we tested the hypothesis that milk oligosaccharides may contribute not only to selective growth of bifidobacteria, but also to their specific adhesive ability. Human milk oligosaccharides (3′sialyllactose and 6′sialyllactose) and a commercial prebiotic (Beneo Orafti P95; oligofructose) were assayed for their ability to promote adhesion of Bifidobacterium longum subsp. infantis ATCC 15697 to HT-29 and Caco-2 human intestinal cells. Treatment with the commercial prebiotic or 3′sialyllactose did not enhance adhesion. However, treatment with 6′sialyllactose resulted in increased adhesion (4.7 fold), while treatment with a mixture of 3′- and 6′-sialyllactose substantially increased adhesion (9.8 fold) to HT-29 intestinal cells. Microarray analyses were subsequently employed to investigate the transcriptional response of B. longum subsp. infantis to the different oligosaccharide treatments. This data correlated strongly with the observed changes in adhesion to HT-29 cells. The combination of 3′- and 6′-sialyllactose resulted in the greatest response at the genetic level (both in diversity and magnitude) followed by 6′sialyllactose, and 3′sialyllactose alone. The microarray data was further validated by means of real-time PCR. The current findings suggest that the increased adherence phenotype of Bifidobacterium longum subsp. infantis resulting from exposure to milk oligosaccharides is multi-faceted, involving transcription factors, chaperone proteins, adhesion-related proteins, and a glycoside hydrolase. This study gives additional insight into the role of milk oligosaccharides within the human intestine and the molecular mechanisms underpinning host-microbe interactions. [ABSTRACT FROM AUTHOR]

Published
2013
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50. Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production.

Author

Miyauchi, Eiji, O'Callaghan, John, Buttó, Ludovica F., Hurley, Gráinne, Melgar, Silvia, Tanabe, Soichi, Shanahan, Fergus, Nally, Kenneth, and O'Toole, Paul W.

Abstract

Enhanced barrier function is one mechanism whereby commensals and probiotic bacteria limit translocation of foreign antigens or pathogens in the gut. However, barrier protection is not exhibited by all probiotic or commensals and the strain-specific molecules involved remain to be clarified. We evaluated the effects of 33 individual Lactobacillus salivarius strains on the hydrogen peroxide (H2O2)- induced barrier impairment in human epithelial Caco-2 cells. These strains showed markedly different effects on H2O2-induced reduction in transepithelial resistance (TER). The effective strains such as UCC118 and CCUG38008 attenuated H2O2-induced disassembly and relocalization of tight junction proteins, but the ineffective strain AH43324 did not. Strains UCC118 and CCUG38008 induced phosphorylation of extracellular signal-regulated kinase (ERK) in Caco-2 cells, and the ERK inhibitor U0126 attenuated the barrier-protecting effect of these strains. In contrast, the AH43324 strain induced phosphorylation of Akt and p38, which was associated with an absence of a protective effect. Global transcriptome analysis of UCC118 and AH43324 revealed that some genes in a bacteriocin gene cluster were upregulated in AH43324 under TER assay conditions. A bacteriocin-negative UCC118 mutant displayed significantly greater suppressive effect on H2O2-induced reduction in TER compared with wild-type UCC118. The wild-type strain augmented H2O2-induced phosphorylation of Akt and p38, whereas a bacteriocin-negative UCC118 mutant did not. These observations indicate that L. salivarius strains are widely divergent in their capacity for barrier protection, and this is underpinned by differences in the activation of intracellular signaling pathways. Furthermore, bacteriocin production appears to have an attenuating influence on lactobacillus-mediated barrier protection. [ABSTRACT FROM AUTHOR]

Published
2012
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