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4. Kinetics and Physiology at Vanishingly Small Substrate Concentrations

Author

Button, D. K., Timmis, Kenneth N., Editor-in-Chief, Boll, Matthias, Series Editor, Geiger, Otto, Series Editor, Goldfine, Howard, Series Editor, Krell, Tino, Series Editor, Lee, Sang Yup, Series Editor, McGenity, Terry J., Series Editor, Rojo, Fernando, Series Editor, Sousa, Diana Z, Series Editor, Stams, Alfons J. M., Series Editor, Steffan, Robert, Series Editor, and Wilkes, Heinz, Series Editor

Published
2018
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5. Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Author

Christensen, L M, Bentsen, L, Krarup Hansen, C, Thomsen, T T, Kruuse, C, Jensen, H H, Hansen, S S, Petrovic, V, Beridze, N, Kakabadze, N, Kherkheulidze, T, Kakabadze, D, Toidze, I, Lobjanidze, N, Akiashvili, N, Tevdoradze, A, Khizanishvili, N, Tsanava, T, Taylor, R, Iniesta, I, Kok, J, Duignan, J, Funnell, M, Cariga, P, Rodriguez, M, Watson, I J, Tennant, S, Macleod, M, Furnace, J, Gow, H, Irvine, J, Joyson, A, Nelson, S, Taylor, V, Smith, M, Bellfield, R, Hairsine, B, Davies, R, Dodd, A, Corrigan, J, Doherty, M, Ahmed, A, Denniss, C, Johnson-Holland, S, Kay, K A, Palau, R Icart, Auld, G, Daboo, P, Erande, R, Grimwood, G, Hove, D, Howaniec, L, Redjep, O, Rangasamay, R, Butt, G, Sandler, D, Reddan, J, Stafford, S, McIlmoyle, J, Maguire, S, Murphy, P, Chambers, J, Guthrie, L, Osborn, M, Steele, A, Burn, M, Benford, A, Misra, A, Hilton, D, O'Brien, E, Amis, E, Finlay, S, Mitchell, J, Geraghty, O, Harvey, K, Hazel, B, Mashate, S, Wilding, P, Sajid, M, Ball, M, Gascoyne, R, Sivakumar, R, Wright, A, Chatterjee, K, Booth, S, Eccleson, H, Kelly, C, Leason, S, Perkins, C, Bruce, D, Brown, E, Clayton, S, Garside, M, Rogers, G, Lawrence, E, Mahmood, S, Watchurst, C, Chadha, D, Glover, L, Holford, L, Smith, K, Walstow, D, Williams, R, O'Shea, L, Goodsell, J, Athulathmudali, C, Barbon, E, Namushi, R, Jacob, P, Johnson, L, Morse, D, McGhee, C, Speirs, O, Atkinson, S, Peacocke, A, Langhorne, P, Graham, R, Wright, F, McAlpine, C, Ravindrane, A, Bajoriene, M, Matter, L, Windebank, S, Giallombardo, E, Dellafera, D, Eglinton, C, Wilson, J, Broughton, D, Chapman, K, Dixon, L, Zaidi, M, Ayes, K, Kessell, J, Manawadu, D, Adegbaju, O, Aeron-Thomas, J, Anderson, K, Brigden, A, Cattermole, E, Good, J, Hassan, S, Khoromana, E, Lee-Carbon, L, Marks, K, Mckenzie, E, Sikondari, N, Cooper, M, Whysall, K, Wynter, I, Bamford, J, Hassan, A, Wanklyn, P, Kambafwile, M, Makawa, L, Waugh, D, Veraque, E, Soliman, MGG, Arif, S, Brown, R, Butler, S, Hewitt, C, Hindle, J, Pusalkar, A, Beadle, H, Chan, K, Siddiqui, M, Dangri, P, Buddha, S, Asokanathan, A, Mistri, A, Eveson, D, Musarrat, K, Manning, L, Anand, S, Christian, P, Khan, S, Patel, C, Sein, M, Banns, J, Gibson, E, Gordon, T, Gruenbeck, Y, Wong, S, Datta, P, Bateman, G, Jackson, L, Needle, A, Duodu, Y, Oliver, R, Padilla-Harris, C, Barber, M, Esson, D, Brodie, F, McInnes, C, Fotherby, K, Butler, D, Morgan, D, Preece, K, Willberry, A, Dent, M, Hammonds, F, Hunt, J, Vernon, C, O'Kane, D, Faola, F, Lai, P, O'Callaghan, J, Smith, C, Price, C, Lakey, R, Riddell, V, Smith, A, Storey, G, Munshi, S, Buck, A, Clarke, J, Gilzeane, N, Godfrey, M, Keshvara, R, Richardson, C, Roffe, J, Ryan, L, Shelton, F, Sunman, W, Tittle, A, Tomlinson, J, Whittamore, K, Wilkes, G, Owusu-Agyei, P, Temple, N, Mangion, D, Hardwick, A, Netherton, K, Nor, A Mohd, Hyams, B, Norman, S, Persad, N, Ragab, S, Dickson, C, Dube, J, Jinks, E, Knops, K, Wadams, B, Ali, K, Gaylard, J, Spurling, G, Sztriha, L, Ajao, T, Alao, M, Chan, F K, Webster, P, Howard, P, Dobson, T J, Hyatt, L, Sims, D, Cunningham, J, Esisi, B, Cassidy, T, Bokhari, M, McClelland, B, Mokoena, B, Gunathilagan, G, Jones, S, Reader, M, Thomas, G, Tilby, S, Findlay, P, Barrett, F, Leslie, F, Ross, S, Shread, I, Okwera, J, Howe, J, Harrington, F, Courtauld, G, Schofield, C, Donnelly, R, Maddula, M, Scott, J, Beavan, J, Muhidden, K, Memon, I, Clarke, M, Hedstrom, A, Mills, L, Hemsley, A, Bowring, A, Boxall, L, Kingwell, H, Keenan, S, Roughan, C, Manoj, A, Cox, P, Fletcher, G, Lopez, P, Emsley, H, Gregary, B, McLoughlin, A, Raj, S, Roffe, C, Abano, N, Barry, A, Butler, A, Carpio, R, Castro, K, Finney, K, Gomm, S, Hiden, J, Grocott, J, Lyjko, S, Maguire, H, Remegoso, A, Sanyal, R, Stevens, S, Natarajan, I, Chembala, J, Muddegowda, G, Warusevitane, A, Blight, A, Balazikova, O, Lawlor, C, Shaw, L, Button, D, Howcroft, D, Lucas, S, Madigan, B, McCann, S, Dixit, A, Barkat, A, Davis, J, Fawcett, M, Finlay, L, Guy, H, Hays, C, Hogg, V, Horsley, E, Hubbuck, C, Pringle, C, Stevenson, C, Storey, K, Thompson, T, Woodward, S, Banerjee, A, Allcock, C, Merotra, S, Douglass, C, Campbell, E, Jarapa, R, Johnes, M, Keaveney, C, Marsden, T, Naing, Z, Perez, J, Shaw, K, Black, T, Anthony, A, Clarke, C, Paterson, J, Deighton, K, Temlett, E, Blank, C, Doyle, C, Duty, S, Gill, K, Harkness, K, Kamara, C, Richards, E, Elfandi, K, Guyler, P, Harman, P, Khuoge, C, Kunhunny, S, Tysoe, S, Moynihan, B, Adedoyin, T, Chopra, N, Dayal, N, Ghatala, R, Jeyaraj, N, Jones, I, Kennedy, F, Kerin, L, Khanom, N, Lewis, S, Maheswaran, S, Montague, L, Niemierko, M, O'Reilly, J, Trippier, S, Watson, F, Wilkinson, P, Young, E, Dizayee, K, Cochrane, H, O'Connell, J, Mokoena, L, Osborne, E, Nair, A, Greig, J, Jenkins, C, Powell, J, Price, F, Chowdhury, M, Brixey, S, Hunt, L, Rands, N, Rose, G, Stoddart, S, Srinivasan, M, Motherwell, N, Shekhar, R, Fuller, T, Lankester, A, Lingwood, P, Rankin, C, Webb, H, Jupp, B, Bell, J, Hann, G, Longland, B, Ovington, C, Bhaskaran, B, Ayres, G, Bailey, C, Bearne, H, Buxton, J, Fitzell, P, Hilaire, C, Kelly, D, Szabo, S, Tomlin, D, Gamble, E, Charles, B, Kumar, R, Fluskey, T, Mellor, Z, Peters, J, Sutton, V, Kenton, A, Martin, I, Nyabadza, S, Ghosh, S, Henry, M, Kumar, B, Ambulo, C, Crawford, S, Nozedar, T, Platton, M, Cvoro, V, Couser, M, McCormick, K, Wilkinson, D, Javaid, K, Hurdowar, S, Attygalle, T, Sundayi, S, Orugun, O, Crowther, H, Jolly, R, Poultney, U, Azim, A, Krasinska-Chavez, M, White, J, Sengupta, N, Margalef, J, Metiu, M G, Meenakshisundaram, S, Dealing, S, Hargroves, D, Beranova, E, Cowie, L, Rudenko, H, Thomson, A, Verrion, A, Rashed, K, Board, S, Buckley, C, Hayward, D, Jenkins, K, Keeling, E, Rowland-Axe, R, Vickers, C, Wood, D, Lehman, A, Patel, M, Russell, H, Rehman, H, Forrest, D, Farren, P, Bath, Philip M, Woodhouse, Lisa J, Appleton, Jason P, Beridze, Maia, Christensen, Hanne, Dineen, Robert A, Duley, Lelia, England, Timothy J, Flaherty, Katie, Havard, Diane, Heptinstall, Stan, James, Marilyn, Krishnan, Kailash, Markus, Hugh S, Montgomery, Alan A, Pocock, Stuart J, Randall, Marc, Ranta, Annemarei, Robinson, Thompson G, Scutt, Polly, Venables, Graham S, and Sprigg, Nikola

Published
2018
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10. Estimated GFR and the Effect of Intensive Blood Pressure Lowering After Acute Intracerebral Hemorrhage

Author

Anderson, C.S., Chalmers, J., Arima, H., Davis, S., Heeley, E., Huang, Y., Lavados, P., Neal, B., Parsons, M.W., Lindley, R., Morgenstern, L., Robinson, T., Stapf, C., Tzourio, C., Wang, J.G., Chen, S., Chen, X.Y., Cui, L., Liu, Z., Lu, C., Wang, J., Wu, S., Xu, E., Yang, Q., Zhang, C., Zhang, J., Beer, R., Schmutzhard, E., Redondo, P., Kaste, M., Soinne, L., Tatlisumak, T., Wartenberg, K., Ricci, S., Klijn, K., Azevedo, E., Chamorro, A., Arnold, M., Fischer, U., Kaul, S., Pandian, J., Boyini, H., Singh, S., Rabinstein, A.A., Estol, C., Silva, G., Olavarria, V.V., Robinson, T.G., Simes, R.J., Bousser, M.-G., Hankey, G., Jamrozik, K., Johnston, S.C., Li, S., Bailey, K., Cheung, T., Delcourt, C., Chintapatla, S., Ducasse, E., Erho, T., Hata, J., Holder, B., Knight, E., Leroux, M., Sassé, T., Odgers, E., Walsh, R., Wolfowicz, Z., Chen, G., Fuentes, S., Peng, B., Schneble, H.-M., Wang, M.-X., Billot, L., Heritier, S., Li, Q., Woodward, M., Abimbola, S., Anderson, S., Chan, E., Cheng, G., Chmielnik, P., Leighton, S., Liu, J.-Y., Rasmussen, B., Saxena, A., Tripathy, S., Armenis, M., Baig, M.A., Naidu, B., Starzec, G., Steley, S., Moles, A., Ruiz, A., Zimmermann, M., Marinho, J., Alves, S., Angelim, R., Araujo, J., Kawakami, L., Bustos, C., Gonzalez, F., Munoz Venturelli, P., Chen, X., Jia, R., Li, N., Qu, S., Shu, Y., Song, A., Sun, J., Xiao, J., Zhao, Y., Huang, Q., Vicaut, E., Chamam, A., Viaud, M.-C., Dert, C., Fiedler, U., Jovis, V., Kabla, S., Marchand, S., Pena, A., Rochaud, V., Mallikarjuna, K., Hasan, N., Berge, E., Sandset, E.C., Forårsveen, A.S., Richardson, D., Kumar, T., Lewin, S., Poulter, N., Field, J., Anjum, A., Wilson, A., Perelmuter, H., Agarie, A.M., Barboza, A.G., Recchia, L.A., Miranda, I.F., Rauek, S.G., Duplessis, R.J., Dewey, H., Walker, L., Petrolo, S., Bladin, C., Sturm, J., Crimmins, D., Griffiths, D., Schutz, A., Zenteno, V., Miteff, F., Spratt, N., Kerr, E., Levi, C.R., Phan, T.G., Ma, H., Sanders, L., Moran, C., Wong, K., Read, S., Henderson, R., Wong, A., Hull, R., Skinner, G., Hand, P., Yan, B., Tu, H., Campbell, B., Blacker, D.J., Wijeratne, T., Pathirage, M., Jasinararchchi, M., Matkovic, Z., Celestino, S., Gruber, F., Vosko, M.R., Diabl, E., Rathmaier, S., Pfausler, B., Helbok, R., Fazekas, F., Fischer, R., Poltrum, B., Zechner, B., Trummer, U., Rutgers, M.P., Peeters, A., Dusart, A., Duray, M.-C., Parmentier, C., Ferrao-Santos, S., Brouns, R., De Raedt, S., De Smedt, A., VanHooff, R.-J., De Keyser, J., Martins, S.C.O., de Almeida, A.G., Broudani, R., Titton, N.F., de Freitas, G.R., Cardoso, F.M., Giesel, L.M., Lima, N.A., Jr, Ferraz de Almeida, A.C., Gomes, R.B., Borges dos Santos, T.S., Veloso Soares, E.M., Neto, O.L.A., Silva, G.S., Gomes, D.L., de Carvalho, F.A., Miranda, M., Marques, A., Zétola, V.F., de Matia, G., Lange, M.C., Montes, J., Reccius, A., Soto, A., Rivas, R., Klapp, C., Illanes, S., Aguilera, C., Castro, A., Figueroa, C., Benavides, J., Salamanca, P., Concha, M.C., Pajarito, J., Araya, P., Guerra, F., Li, Y., Liu, G., Wang, B., Chong, Y., He, M., Wang, L., Liu, J., Zhang, X., Lai, C., Jiang, H., Cui, S., Tao, Q., Zhang, Y., Yao, S., Xu, M., Xiao, H., Hu, J., Tang, J., Ji, H., Jiang, M., Yu, F., Yang, X., Guo, X., Wang, Y., Wu, L., Gao, Y., Sun, D., Huang, X., Liu, L., Li, P., Jiang, Y., Li, H., Lu, H., Zhou, J., Yuan, C., Qi, X., Qiu, F., Qian, H., Wang, W., Sun, W., Li, F., Liu, R., Peng, Q., Ren, Z., Fan, C., Wang, H., Wang, T., Shi, F., Duan, C., Chen, Z., Tan, X., Zhao, Z., Chen, J., Han, T., Zhang, L., Hu, Q., Hou, Q., Zhao, X., Zeng, G., Ma, L., Wang, F., Zeng, L., Guo, Z., Fu, Y., Song, Y., Tai, L., Liu, X., Su, X., Yang, Y., Dong, R., Xu, Y., Tian, S., Cheng, S., Su, L., Xie, X., Xu, T., Geng, D., Yan, X., Fan, H., Zhao, N., Wang, S., Yang, J., Yan, M., Li, L., Li, Z., Xu, X., Lian, Y., Sun, H., Liu, D., Wang, N., Tang, Q., Han, Z., Feng, L., Cui, Y., Tian, J., Chang, H., Sun, X., Liu, C., Wen, Z., Lin, Q., Sun, L., Hu, B., Zou, M., Bao, Q., Lin, X., Zhao, L., Tian, X., Wang, X., Li, X., Hao, L., Duan, Y., Wang, R., Wei, Z., Ren, S., Ren, H., Dong, Y., Cheng, Y., Liu, W., Han, J., Zhang, Z., Zhu, J., Qian, J., Sun, Y., Liu, K., Long, F., Peng, X., Zhang, Q., Yuan, Z., Wang, C., Huang, M., He, P., You, Y., Xia, J., Zhou, L., Hou, Y., Qi, Y., Mei, L., Lu, R., Ping, L., Zhou, S., Zhang, S., Zou, R., Guo, J., Li, M., Wei, W., Curtze, S., Saarela, M., Strbian, D., Scheperjans, F., De Broucker, T., Henry, C., Cumurciuc, R., Ibos-Augé, N., Zéghoudi, A.-C., Pico, F., Dereeper, O., Simian, M.-C., Boisselier, C., Mahfoud, A., Timsit, S., Merrien, F.M., Guillon, B., Sevin, M., Herisson, F., Magne, C., Ameri, A., Cret, C., Stefanizzi, S., Klapzcynski, F., Denier, C., Sarov-Riviere, M., Reiner, P., Mawet, J., Hervé, D., Buffon, F., Touzé, E., Domigo, V., Lamy, C., Calvet, D., Pasquini, M., Alamowitch, S., Favrole, P., Muresan, I.-P., Crozier, S., Rosso, C., Pires, C., Leger, A., Deltour, S., Cordonnier, C., Henon, H., Rossi, C., Zuber, M., Bruandet, M., Tamazyan, R., Join-Lambert, C., Juettler, E., Krause, T., Maul, S., Endres, M., Jungehulsing, G.J., Hennerici, M., Griebe, M., Sauer, T., Knoll, K., Huber, R., Knauer, K., Knauer, C., Raubold, S., Schneider, H., Hentschel, H., Lautenschläger, C., Schimmel, E., Dzialowski, I., Foerch, C., Lorenz, M., Singer, O., Meyer dos Santos, I.M.R., Hartmann, A., Hamann, A., Schacht, A., Schrader, B., Teíchmann, A., Wartenberg, K.E., Mueller, T.J., Jander, S., Gliem, M., Boettcher, C., Rosenkranz, M., Beck, C., Otto, D., Thomalla, G., Cheng, B., Wong, K.S., Leung, T.W., Soo, Y.O.Y., Prabhakar, S., Kesavarapu, S.R., Gajjela, P.K., Chenna, R.R., Ummer, K., Basheer, M., Andipet, A., Jagarlapudi, M.K.M., Mohammed, A.U.R., Pawar, V.G., Eranki, S.S.K., Singh, Y., Akhtar, N., Borah, N.C., Ghose, M., Choudhury, N., Ichaporia, N.R., Shendge, J., Khese, S., Pamidimukkala, V., Inbamuthaiah, P., Nuthakki, S.R., Tagallamudi, N.M.R., Gutti, A.K., Khurana, D., Kesavarapu, P., Jogi, V., Garg, A., Samanta, D., Sarma, G.R.K., Nadig, R., Mathew, T., Anandan, M.A., Caterbi, E., Zini, A., Cavazzuti, M., Casoni, F., Pentore, R., Falzone, F., Mazzoli, T., Greco, L.M., Menichetti, C., Coppola, F., Cenciarelli, S., Gallinella, E., Mattioni, A., Condurso, R., Sicilia, I., Zampolini, M., Corea, F., Barbi, M., Proietti, C., Toni, D., Pieroni, A., Anzini, A., Falcou, A., Demichele, M., Klijn, C.J.M., Tveiten, A., Thortveit, E.T., Pettersen, S., Holand, N., Hitland, B., Johnsen, S.H., Eltoft, A., Wasay, M., Kamal, A., Iqrar, A., Ali, L., Begum, D., Gama, G., Fonseca, L., Moreira, G., Veloso, L.M., Pinheiro, D., Paredes, L., Rozeira, C., Gregorio, T., Segura Martin, T., Ayo, O., Garcia-Garcia, J., Feria Vilar, I., Gómez Fernández, I., Amaro, S., Urra, X., Obach, V., Cervera, A., Silva, Y., Serena, J., Castellanos, M., Terceno, M., Van Eendenburg, C., Weck, A., Findling, O., Lüdi, R., Warburton, E.A., Day, D., Butler, N., Bumanlag, E., Caine, S., Steele, A., Osborn, M., Dodd, E., Murphy, P., Esisi, B., Brown, E., Hayman, R., Baliga, V.K.V., Minphone, M., Kennedy, J., Reckless, I., Pope, G., Teal, R., Michael, K., Manawadu, D., Kalra, L., Lewis, R., Mistry, B., Cattermole, E., Hassan, A., Mandizvidza, L., Bamford, J., Brooks, H., Bedford, C., Whiting, R., Baines, P., Hussain, M., Harvey, M., Fotherby, K., McBride, S., Bourke, P., Morgan, D., Jennings-Preece, K., Price, C., Huntley, S., Riddell, V.E., Storey, G., Lakey, R.L., Subramanian, G., Jenkinson, D., Kwan, J., David, O., Tiwari, D., James, M., Keenan, S., Eastwood, H., Shaw, L., Kaye, P., Button, D., Madigan, B., Williamson, D., Dixit, A., Davis, J., Hossain, M.O., Ford, G.A., Parry-Jones, A., O'Loughlin, V., Jarapa, R., Naing, Z., Lovelock, C., O'Reilly, J., Khan, U., Bhalla, A., Rudd, A., Birns, J., Werring, D.J., Law, R., Perry, R., Jones, I., Erande, R., Roffe, C., Natarajan, I., Ahmad, N., Finney, K., Lucas, J., Mistri, A., Eveson, D., Marsh, R., Haunton, V., Fugate, J.E., Lepore, S.W., Zheng, Danni, Sato, Shoichiro, Arima, Hisatomi, Heeley, Emma, Delcourt, Candice, Cao, Yongjun, Chalmers, John, and Anderson, Craig S.

Published
2016
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15. Standardising definitions for the pre-eclampsia core outcome set: A consensus development study

Author

Duffy, J. M. N., Cairns, A. E., Magee, L. A., von Dadelszen, P., van 't Hooft, J., Gale, C., Brown, M., Chappell, L. C., Grobman, W. A., Fitzpatrick, R., Karumanchi, S. A., Lucas, D. N., Mol, B., Stark, M., Thangaratinam, S., Wilson, M. J., Williamson, P. R., Ziebland, S., Mcmanus, R. J., Abalos, E. J., Adamson, C. C. D., Akadri, A. A., Akturk, Z., Allegaert, K., Angel-Muller, E., Antretter, J., Ashdown, H. F., Audibert, F., Auger, N., Aygun, C., Babic, I., Bagga, R., Baker, J. M., Beebeejaun, Y., Bhakta, P., Bhandari, V., Bhattacharya, S., Blanker, M. H., Bloomfield, F. H., Bof, A., Brennan, S. M., Broekhuijsen, K., Broughton Pipkin, F., Browne, J. L., Browning, R. M., Bull, J. W., Butt, A., Button, D., Campbell, J. P., Campbell, D. M., Carbillon, L., Carthy, S., Casely, E., Cave, J. A., Cecatti, J. G., Chamillard, M. E., Chassard, D., Checheir, N. C., Chulkov, V. S., Cluver, C. A., Crawford, C. F., Daly, M. C., Darmochwal-Kolarz, D. A., Davies, R. E., Davies, M. W., Dawson, J. S., Dobson, N., Dodd, C. N., Donald, F., Duley, L., Epstein-Mares, J., Erez, O., Evans, E., Farlie, R. N., Ferris, A. V., Frankland, E. M., Freeman, D. J., Gainder, S., Ganzevoort, W., Gbinigie, O. A., Gerval, M. -O., Ghosh, S. K., Gingel, L. J., Glogowska, M., Goodlife, A., Gough, K. L., Green, J. R., Gul, F., Haggerty, L., Hall, D. R., Hallman, M., Hamilton, L. M., Hammond, S. J., Harlow, S. D., Hays, K. E., Hickey, S. C., Higgins, M., Hinton, L., Hobson, S. R., Hogg, M. J., Hollands, H. J., Homer, C. S. E., Hoodbhoy, Z., Howell, P., Huppertz, B., Husain, S., Jacoby, S. D., Jacqz-Aigrain, E., Jenkins, G., Jewel, D., Johnson, M. J., Johnston, C. L., Jones, P. M., Kantrowitz-Gordon, I., Khan, R. -U., Kirby, L. J., Kirk, C., Knight, M., Korey, M. T., Lee, G. J., Lee, V. W., Levene, L. S., Londero, A. P., Lust, K. M., Mackenzie, V., Malha, L., Mattone, M., Mccartney, D. E., Mcfadden, A., Mckinstry, B. H., Middleton, P. F., Mills, D. J., Mistry, H. D., Mitchell, C. A., Mockler, J. C., Molsher, S. -A., Monast, E. S., Moodley, J., Mooij, R., Moore, E. L., Morgan, L., Moulson, A., Mughal, F., Mundle, S. R., Munoz, M. A., Murray, E., Nagata, C., Nair, A. S., Nakimuli, A., Nath, G., Newport, R. S., Oakeshott, P., Ochoa-Ferraro, M. R., Odendaal, H., Ohkuchi, A., Oliveira, L., Ortiz-Panozo, E., Oudijk, M. A., Oygucu, S. E., Paech, M. J., Painter, R. C., Parry, C. L., Payne, B. A., Pearson, E. L., Phupong, V., Pickett, N., Pickles, K. A., Plumb, L. K., Prefumo, F., Preston, R., Ray, J. G., Rayment, J., Regan, L. V., Rey, E., Robson, E. J., Rubin, A. N., Rubio-Romero, J. A., Rull, K., Sass, N., Sauve, N., Savory, N. A., Scott, J. R., Seaton, S. E., Seed, P. T., Shakespeare, J. M., Shand, A. W., Sharma, S., Shaw, T. Y., Smedley, K. L., Smith, D., Smith Conk, A., Soward, D., Stepan, H., Stroumpoulis, K., Surendran, A., Takeda, S., Tan, L., Theriot, B. S., Thomas, H. F., Thompson, K., Thompson, P. I., Thompson, M. J., Toms, L., Torney, K. L. H. T., Treadwell, J. S., Tucker, K. L., Turrentine, M. A., Van Hecke, O., Van Oostwaard, M. F., Vasquez, D. N., Vaughan, D. J. A., Vinturache, A., Walker, J., Wardle, S. P., Wasim, T., Waters, J. H., Whitehead, C. L., Wolfson, A., Yeo, S., Zermansky, A. G., (iHOPE), International Collaboration to Harmonise Outcomes for Pre-eclampsia, Life Course Epidemiology (LCE), University of Oxford, University College London, King’s College London, Academic Medical Center, Imperial College London, St George Hospital and University of New South Wales, Northwestern University, Cedars-Sinai Medical Center, London North West University Healthcare NHS Trust, Monash University, University of Adelaide, Barts and The London School of Medicine and Dentistry, University of Sheffield, University of Liverpool, Centro Rosarino de Estudios Perinatales, Chelsea and Westminster Hospital NHS Foundation Trust, Babcock University, Ailem Academic Counselling, KU Leuven, Universidad Nacional de Colombia, Northwell Health, Université de Montréal, University of Montreal Hospital Centre, Ondokuz Mayıs University, Prince Sultan Military Medical City, Postgraduate Institute of Medical Education and Research, Fetal Medicine Research Institute, University Hospital Limerick, Drexel University, University of Aberdeen, University of Groningen, University of Auckland, Haaglanden Medisch Centrum, Nottingham University Medical School, Utrecht University, King Edward Memorial Hospital for Women, Imperial College Healthcare NHS Trust, Jean-Verdier Hospital, Downland Practice, Universidade Estadual de Campinas (UNICAMP), Université Lyon, University of North Carolina School of Medicine, South Ural State Medical University, Stellenbosch University, Irish Neonatal Health Alliance, University of Rzeszow, Royal Brisbane and Women’s Hospital, Nottingham University Hospitals NHS Trust, University Hospitals of Leicester, North Bristol NHS Trust, University of Nottingham, Soroka University Medical Center Ben Gurion University of the Negev, St George’s University Hospitals NHS Foundation Trust, Hospitalsenhed Midt, University of Glasgow, Amsterdam Universitair Medische Centra, All India Institute of Medical Sciences Patna, Luton and Dunstable University Hospital, Khyber Medical University Institution of Medical Sciences, Midwife Mid Essex Hospitals NHS Trust, University of Oulu, University of Michigan, Bastyr University, Irish Nurses and Midwives Organisation, University of Toronto, Barts Health NHS Trust, University Hospitals Plymouth NHS Trust, Burnet Institute, Aga Khan University, Medical University of Graz, Homerton University Hospital NHS Foundation Trust, Mount Royal University, Université de Paris, Royal Surrey County Hospital, University Hospital Southampton NHS Foundation Trust, University of Washington School of Nursing, Evelina London Children's Hospital Neonatal Unit, University of Sydney, University of Leicester, Academic Hospital of Udine, NHS Borders, Weill Cornell Medical College, University of Dundee, University of Edinburgh, South Australian Health and Medical Research Institute, Monash University and Monash Health, United Lincolnshire Hospitals NHS Trust, University of Kwa Zulu-Natal, Beatrix Hospital, Keele University, Government Medical College, Institut Catala de la Salut. IdiapJgol, National Center for Child Health and Development, Basavatarakam Indo-American Cancer Hospital and Research Institute, Axon Anaesthesia Associates, Pennine Acute Hospitals NHS Trust, University of London, Norfolk and Norwich University Hospital, Jichi Medical University School of Medicine, Universidade Estadual Paulista (UNESP), National Institute of Public Health, University of Kyrenia, King Edward Memorial Hospital, Amsterdam University Centres, University of British Columbia, Chulalongkorn University, University of Brescia, University Of British Columbia, University of Montreal, Women's Clinic of Tartu University Hospital, Universidade Federal de São Paulo (UNIFESP), Université de Sherbrooke, University Hospital of Wales, University of Iowa, King's College London, Westmead Hospital, Princess Royal Maternity, Leipzig University, Centre Hospitalier Public du Cotentin, Lewisham and Greenwich NHS Trust, Juntendo University Faculty of Medicine, Western Sydney University, National Institute of Health Research, University of Washington, Baylor College of Medicine, Capelle aan den Ijssel, Sanatorio Anchorena, Oxford University Hospitals NHS Foundation Trust, University of Leeds, Institute of Medical Sciences, UPMC Magee Womens Hospital, Penn Medicine Princeton Health, University of North Carolina at Chapel Hill, and Obstetrics and Gynaecology

Subjects
Adult, medicine.medical_specialty, Consensus, Delphi Technique, Standardization, Birth weight, Psychological intervention, Randomised controlled trials, 030204 cardiovascular system & hematology, Outcome (game theory), 03 medical and health sciences, Hypertension in pregnancy, Outcome measure, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, Consensus development study, Internal Medicine, medicine, Humans, Set (psychology), 030219 obstetrics & reproductive medicine, Eclampsia, business.industry, Pregnancy Outcome, Obstetrics and Gynecology, Core outcome set, Reference Standards, medicine.disease, Pre-eclampsia, Pregnancy Complications, Core (game theory), Treatment Outcome, Systematic review, Family medicine, 1114 Paediatrics and Reproductive Medicine, Female, International Collaboration to Harmonise Outcomes for Pre-eclampsia (iHOPE), business
Abstract

Made available in DSpace on 2022-04-28T19:29:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-07-01 Medical Research Council Canada National Institute for Health Research Objectives: To develop consensus definitions for the core outcome set for pre-eclampsia. Study design: Potential definitions for individual core outcomes were identified across four formal definition development initiatives, nine national and international guidelines, 12 Cochrane systematic reviews, and 79 randomised trials. Eighty-six definitions were entered into the consensus development meeting. Ten healthcare professionals and three researchers, including six participants who had experience of conducting research in low- and middle-income countries, participated in the consensus development process. The final core outcome set was approved by an international steering group. Results: Consensus definitions were developed for all core outcomes. When considering stroke, pulmonary oedema, acute kidney injury, raised liver enzymes, low platelets, birth weight, and neonatal seizures, consensus definitions were developed specifically for low- and middle-income countries because of the limited availability of diagnostic interventions including computerised tomography, chest x-ray, laboratory tests, equipment, and electroencephalogram monitoring. Conclusions: Consensus on measurements for the pre-eclampsia core outcome set will help to ensure consistency across future randomised trials and systematic reviews. Such standardization should make research evidence more accessible and facilitate the translation of research into clinical practice. Video abstract can be available at: www.dropbox.com/s/ftrgvrfu0u9glqd/6.%20Standardising%20definitions%20in%20teh%20pre-eclampsia%20core%20outcome%20set%3A%20a%20consensus%20development%20study.mp4?dl=0. Nuffield Department of Primary Care Health Sciences University of Oxford Institute for Women’s Health University College London Department of Women and Children’s Health School of Life Course Sciences King’s College London Department of Obstetrics and Gynecology Amsterdam UMC Academic Medical Center Academic Neonatal Medicine Imperial College London Department of Renal Medicine St George Hospital and University of New South Wales Department of Obstetrics and Gynaecology Feinberg School of Medicine Northwestern University Health Services Research Unit Nuffield Department of Population Health University of Oxford Cedars-Sinai Medical Center London North West University Healthcare NHS Trust Women’s Health Care Research Group Department of Obstetrics and Gynaecology Monash University Department of Obstetrics and Gynaecology University of Adelaide Women’s Health Research Unit Barts and The London School of Medicine and Dentistry School of Health and Related Research University of Sheffield MRC North West Hub for Trials Methodology Research Department of Biostatistics University of Liverpool Centro Rosarino de Estudios Perinatales Chelsea and Westminster Hospital NHS Foundation Trust Babcock University Ailem Academic Counselling KU Leuven Universidad Nacional de Colombia Northwell Health University of Oxford Université de Montréal University of Montreal Hospital Centre Ondokuz Mayıs University Prince Sultan Military Medical City Postgraduate Institute of Medical Education and Research King's Fertility Fetal Medicine Research Institute University Hospital Limerick Drexel University University of Aberdeen University of Groningen University of Auckland Haaglanden Medisch Centrum Nottingham University Medical School Utrecht University King Edward Memorial Hospital for Women Imperial College Healthcare NHS Trust Jean-Verdier Hospital Downland Practice University of Campinas Université Lyon University of North Carolina School of Medicine South Ural State Medical University Stellenbosch University Irish Neonatal Health Alliance University of Rzeszow Royal Brisbane and Women’s Hospital Nottingham University Hospitals NHS Trust University Hospitals of Leicester North Bristol NHS Trust University of Nottingham Soroka University Medical Center Ben Gurion University of the Negev St George’s University Hospitals NHS Foundation Trust Hospitalsenhed Midt University of Glasgow Amsterdam Universitair Medische Centra All India Institute of Medical Sciences Patna Luton and Dunstable University Hospital Khyber Medical University Institution of Medical Sciences Midwife Mid Essex Hospitals NHS Trust University of Oulu University of Michigan Bastyr University Irish Nurses and Midwives Organisation University of Toronto Barts Health NHS Trust University Hospitals Plymouth NHS Trust Burnet Institute Aga Khan University Medical University of Graz Homerton University Hospital NHS Foundation Trust Mount Royal University Université de Paris Royal Surrey County Hospital University Hospital Southampton NHS Foundation Trust University of Washington School of Nursing Evelina London Children's Hospital Neonatal Unit University of Sydney University of Leicester Academic Hospital of Udine NHS Borders Weill Cornell Medical College University of Dundee University of Edinburgh South Australian Health and Medical Research Institute University of Sheffield Monash University and Monash Health United Lincolnshire Hospitals NHS Trust University of Kwa Zulu-Natal Beatrix Hospital Keele University Government Medical College Institut Catala de la Salut. IdiapJgol University College London National Center for Child Health and Development Basavatarakam Indo-American Cancer Hospital and Research Institute Axon Anaesthesia Associates Pennine Acute Hospitals NHS Trust St George's University of London Norfolk and Norwich University Hospital Jichi Medical University School of Medicine São Paulo State University National Institute of Public Health University of Kyrenia King Edward Memorial Hospital Amsterdam University Centres University of British Columbia Chulalongkorn University University of Brescia University Of British Columbia University of Montreal Women's Clinic of Tartu University Hospital Universidade Federal de São Paulo Université de Sherbrooke University Hospital of Wales University of Iowa King's College London Westmead Hospital Princess Royal Maternity Leipzig University Centre Hospitalier Public du Cotentin Lewisham and Greenwich NHS Trust Juntendo University Faculty of Medicine Western Sydney University National Institute of Health Research University of Washington Baylor College of Medicine Capelle aan den Ijssel Sanatorio Anchorena Oxford University Hospitals NHS Foundation Trust University of Leeds Institute of Medical Sciences UPMC Magee Womens Hospital Penn Medicine Princeton Health University of North Carolina at Chapel Hill São Paulo State University

Published
2020
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16. The contribution of peer research in evaluating complex public health interventions: examples from two UK community empowerment projects

Author

Southby, K, Coan, S, Rushworth, S, South, J, Bagnall, A-M, Lam, T, Woodward, J, Button, D, Southby, K, Coan, S, Rushworth, S, South, J, Bagnall, A-M, Lam, T, Woodward, J, and Button, D

Abstract

Background Peer-research is steered and conducted by people with lived experience of the issues being researched. This paper explores the value of peer-research in two complex public health intervention evaluations in the UK. Methods Reports from 18 peer research projects, completed by residents from 12 communities in the UK taking part in two community empowerment interventions, were analysed using cross-case analysis. Results Undertaking peer research helped to build the evaluation and research skills within individual projects as well as providing data on other outcomes related to the programmes Theory of Change. Some peer researchers, however, felt unprepared for the activity despite support from the academic team and were unsatisfied with project outcomes. While peer research projects provided more opportunities for local residents to engage with the overall evaluations, there was an overreliance on people closely connected to the programmes to be peer researchers. The peer research projects explored topics that were broader than the aims and objectives of the overall programme evaluations. All provided insight into the context in which projects occurred, while some also informed understanding of programme change mechanisms. Conclusions Including peer research as part of complex public health intervention evaluations can help uncover important contextual and ecological details beyond the reach of more traditional evaluation data collection. Peer research can also empower and build research/evaluation capacity within communities, which is particularly pertinent for community empowerment interventions.

Published
2022

27. A core outcome set for pre‐eclampsia research : an international consensus development study

Author

Duffy, JMN, Cairns, AE, Richards‐Doran, D, van 't Hooft, J, Gale, C, Brown, M, Chappell, LC, Grobman, WA, Fitzpatrick, R, Karumanchi, SA, Khalil, A, Lucas, DN, Magee, LA, Mol, BW, Stark, M, Thangaratinam, S, Wilson, MJ, von Dadelszen, P, Williamson, PR, Ziebland, S, McManus, RJ, Abalos, EJ, Adamson, CCD, Akadri, AA, Akturk, Z, Allegaert, K, Angel‐Müller, E, Antretter, J, Audibert, F, Auger, N, Aygun, C, Babic, I, Bagga, R, Baker, JM, Bhandari, V, Bhattacharya, S, Blanker, MH, Bloomfield, FH, Bof, A, Brennan, SM, Broekhuijsen, K, Fiona Broughton Pipkin, E, Browne, JL, Browning, RM, Bull, JW, Butt, A, Button, D, Campbell, JP, Campbell, DM, Carbillon, L, Carthy, S, Casely, E, Cave, JA, Cecatti, JG, Chamillard, ME, Chassard, D, Checheir, NC, Chulkov, VS, Cluver, CA, Crawford, CF, Daly, MC, Darmochwal‐Kolarz, DA, Davies, RE, Davies, MW, Dawson, JS, Dobson, N, Dodd, CN, Donald, F, Duley, L, Epstein‐Mares, J, Erez, O, Evans, E, Farlie, RN, Ferris, AV, Frankland, EM, Freeman, DJ, Gainder, S, Ganzevoort, W, Gbinigie, OA, Ghosh, SK, Glogowska, M, Goodlife, A, Gough, KL, Green, JR, Gul, F, Haggerty, L, Hall, DR, Hallman, M, Hammond, SJ, Harlow, SD, Hays, KE, Hickey, SC, Higgins, M, Hinton, L, Hobson, SR, Hogg, MJ, Hollands, HJ, Homer, CSE, Hoodbhoy, Z, Howell, P, Huppertz, B, Husain, S, Jacoby, SD, Jacqz‐Aigrain, E, Jenkins, G, Jewel, D, Johnson, MJ, Johnston, CL, Jones, PM, Kantrowitz‐Gordon, I, Khan, R, Kirby, LJ, Kirk, C, Knight, M, Korey, MT, Lee, GJ, Lee, VW, Levene, LS, Londero, AP, Lust, KM, MacKenzie, V, Malha, L, Mattone, M, McCartney, DE, McFadden, A, McKinstry, BH, Middleton, PF, Mistry, HD, Mitchell, CA, Mockler, JC, Molsher, S, Monast, ES, Moodley, J, Mooij, R, Moore, EL, Morgan, L, Moulson, A, Mughal, F, Mundle, SR, Angel Munoz, M, Murray, E, Nagata, C, Nair, AS, Nakimuli, A, Nath, G, Newport, RS, Oakeshott, P, Ochoa‐Ferraro, MR, Odendaal, H, Ohkuchi, A, Oliveira, L, Ortiz‐Panozo, E, Oudijk, MA, Oygucu, SE, Paech, MJ, Painter, RC, Parry, CL, Payne, BA, Pearson, EL, Phupong, V, Pickett, N, Pickles, KA, Plumb, LK, Prefumo, F, Preston, R, Ray, JG, Rayment, J, Regan, LV, Rey, E, Robson, EJ, Rubin, AN, Rubio‐Romero, JA, Rull, K, Sass, N, Sauvé, N, Savory, NA, Scott, JR, Seaton, SE, Seed, PT, Shakespeare, JM, Shand, AW, Sharma, S, Shaw, TY, Smedley, KL, Smith, D, Smith Conk, A, Soward, D, Stepan, H, Stroumpoulis, K, Surendran, A, Takeda, S, Tan, L, Theriot, BS, Thomas, HF, Thompson, K, Thompson, PI, Thompson, MJ, Torney, KLHT, Treadwell, JS, Tucker, KL, Turrentine, MA, Van Hecke, O, Van Oostwaard, MF, Vasquez, DN, Vaughan, DJA, VInturache, A, Walker, J, Wardle, SP, Wasim, T, Waters, JH, Whitehead, CL, Wolfson, A, Yeo, S, and Zermansky, AG

Subjects
reproductive and urinary physiology
Abstract

Objective\ud To develop a core outcome set for pre‐eclampsia.\ud \ud Design\ud Consensus development study.\ud \ud Setting\ud International.\ud \ud Population\ud Two hundred and eight‐one healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated.\ud \ud Methods\ud Modified Delphi method and Modified Nominal Group Technique.\ud \ud Results\ud A long‐list of 116 potential core outcomes was developed by combining the outcomes reported in 79 pre‐eclampsia trials with those derived from thematic analysis of 30 in‐depth interviews of women with lived experience of pre‐eclampsia. Forty‐seven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, small‐for‐gestational‐age, neonatal mortality, seizures, admission to neonatal unit required and respiratory support.\ud \ud Conclusions\ud The core outcome set for pre‐eclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies.

Published
2020

28. A core outcome set for pre-eclampsia research: an international consensus development study.

Author

Ghosh S.K., Daly M.C., Darmochwal-Kolarz D.A., Davies R.E., Davies M.W., Dawson J.S., Dobson N., Dodd C.N., Donald F., Duley L., Epstein-Mares J., Erez O., Evans E., Farlie R.N., Ferris A.V., Frankland E.M., Freeman D.J., Gainder S., Ganzevoort W., Hamilton L.M., Hammond S.J., Harlow S.D., Hays K.E., Hickey S.C., Higgins M., Hinton L., Hobson S.R., Hogg M.J., Hollands H.J., EH C.S.E., Hoodbhoy Z., Howell P., Huppertz B., Husain S., Jacoby S.D., Jacqz-Aigrain E., Jenkins G., Jewel D., Johnson M.J., Johnston C.L., Jones P.M., Kantrowitz-Gordon I., Khan R.-U., Kirby L.J., Kirk C., Knight M., Korey M.T., Lee G.J., Lee V.W., Levene L.S., Londero A.P., Lust K.M., MacKenzie V., Malha L., Mattone M., McCartney D.E., McFadden A., McKinstry B.H., Middleton P.F., Mistry H.D., Mitchell C.A., Mockler J.C., Molsher S.-A., Monast E.S., Moodley E.J., Mooij R., Moore E.L., Morgan L., Moulson A., Mughal F., Mundle S.R., Munoz M.A., Murray E., Nagata C., Nair A.S., Nakimuli A., Nath G., Newport R.S., Oakeshott P., Ochoa-Ferraro M.R., Odendaal H., Ohkuchi A., Oliveira L., Ortiz-Panozo E., Oudijk M.A., Oygucu S.E., Paech M.J., Painter R.C., Parry C.L., Payne B.A., Pearson E.L., Phupong V., Pickett N., Pickles K.A., Plumb L.K., Prefumo F., Preston R., Ray J.G., Rayment J., Regan L.V., Rey E., Robson E.J., Rubin A.N., Rubio-Romero A.N., Rull K., Sass N., Sauve N., Savory N.A., Scott J.R., Seaton S.E., Seed P.T., Shakespeare J.M., Shand A.W., Sharma S., Shaw T.Y., Smedley K.L., Smith D., Conk A.S., Soward D., Stepan H., Stroumpoulis K., SurenDr A., Takeda S., Tan L., Theriot B.S., Thomas H.F., Thompson K., Thompson P.I., Thompson M.J., Toms L., Torney K.L.H.T., Treadwell J.S., Tucker K.L., Turrentine M.A., Van Hecke O., Van Oostwaard M.F., Vasquez D.N., AV D.J.A., VInturache A., Walker J., Wardle S.P., Wasim T., Waters J.H., Whitehead C.L., Wolfson A., Yeo S., Duffy J.M.N., Cairns A.E., Richards-Doran D., van 't Hooft J., Gale C., Brown M., Chappell L.C., Grobman W.A., Fitzpatrick R., Karumanchi S.A., Khalil A., Lucas D.N., Magee L.A., Mol B.W., Stark M., Thangaratinam S., Wilson M.J., von Dadelszen P., Williamson P.R., Ziebland S., McManus R.J., Abalos E.J., DA C.C.D., AkaDr A.A., Akturk Z., Allegaert K., Angel-Muller E., Antretter J., Ashdown H.F., Audibert F., Auger N., Aygun C., Babic I., Bagga R., Baker J.M., Bhakta P., Bhandari V., Bhattacharya S., Blanker M.H., Bloomfield F.H., Bof A., Brennan S.M., Broekhuijsen K., Pipkin E.F.B., Browne J.L., Browning R.M., Bull J.W., Butt A., Button D., Campbell J.P., Campbell D.M., Carbillon L., Carthy S., Casely E., Cave J.A., Cecatti J.G., Chamillard M.E., Chassard D., Checheir N.C., Chulkov V.S., Cluver C.A., Crawford C.F., Gbinigie O.A., Glogowska M., Goodlife A., Gough K.L., Green J.R., Gul F., Haggerty L., Hall D.R., Hallman M., Ghosh S.K., Daly M.C., Darmochwal-Kolarz D.A., Davies R.E., Davies M.W., Dawson J.S., Dobson N., Dodd C.N., Donald F., Duley L., Epstein-Mares J., Erez O., Evans E., Farlie R.N., Ferris A.V., Frankland E.M., Freeman D.J., Gainder S., Ganzevoort W., Hamilton L.M., Hammond S.J., Harlow S.D., Hays K.E., Hickey S.C., Higgins M., Hinton L., Hobson S.R., Hogg M.J., Hollands H.J., EH C.S.E., Hoodbhoy Z., Howell P., Huppertz B., Husain S., Jacoby S.D., Jacqz-Aigrain E., Jenkins G., Jewel D., Johnson M.J., Johnston C.L., Jones P.M., Kantrowitz-Gordon I., Khan R.-U., Kirby L.J., Kirk C., Knight M., Korey M.T., Lee G.J., Lee V.W., Levene L.S., Londero A.P., Lust K.M., MacKenzie V., Malha L., Mattone M., McCartney D.E., McFadden A., McKinstry B.H., Middleton P.F., Mistry H.D., Mitchell C.A., Mockler J.C., Molsher S.-A., Monast E.S., Moodley E.J., Mooij R., Moore E.L., Morgan L., Moulson A., Mughal F., Mundle S.R., Munoz M.A., Murray E., Nagata C., Nair A.S., Nakimuli A., Nath G., Newport R.S., Oakeshott P., Ochoa-Ferraro M.R., Odendaal H., Ohkuchi A., Oliveira L., Ortiz-Panozo E., Oudijk M.A., Oygucu S.E., Paech M.J., Painter R.C., Parry C.L., Payne B.A., Pearson E.L., Phupong V., Pickett N., Pickles K.A., Plumb L.K., Prefumo F., Preston R., Ray J.G., Rayment J., Regan L.V., Rey E., Robson E.J., Rubin A.N., Rubio-Romero A.N., Rull K., Sass N., Sauve N., Savory N.A., Scott J.R., Seaton S.E., Seed P.T., Shakespeare J.M., Shand A.W., Sharma S., Shaw T.Y., Smedley K.L., Smith D., Conk A.S., Soward D., Stepan H., Stroumpoulis K., SurenDr A., Takeda S., Tan L., Theriot B.S., Thomas H.F., Thompson K., Thompson P.I., Thompson M.J., Toms L., Torney K.L.H.T., Treadwell J.S., Tucker K.L., Turrentine M.A., Van Hecke O., Van Oostwaard M.F., Vasquez D.N., AV D.J.A., VInturache A., Walker J., Wardle S.P., Wasim T., Waters J.H., Whitehead C.L., Wolfson A., Yeo S., Duffy J.M.N., Cairns A.E., Richards-Doran D., van 't Hooft J., Gale C., Brown M., Chappell L.C., Grobman W.A., Fitzpatrick R., Karumanchi S.A., Khalil A., Lucas D.N., Magee L.A., Mol B.W., Stark M., Thangaratinam S., Wilson M.J., von Dadelszen P., Williamson P.R., Ziebland S., McManus R.J., Abalos E.J., DA C.C.D., AkaDr A.A., Akturk Z., Allegaert K., Angel-Muller E., Antretter J., Ashdown H.F., Audibert F., Auger N., Aygun C., Babic I., Bagga R., Baker J.M., Bhakta P., Bhandari V., Bhattacharya S., Blanker M.H., Bloomfield F.H., Bof A., Brennan S.M., Broekhuijsen K., Pipkin E.F.B., Browne J.L., Browning R.M., Bull J.W., Butt A., Button D., Campbell J.P., Campbell D.M., Carbillon L., Carthy S., Casely E., Cave J.A., Cecatti J.G., Chamillard M.E., Chassard D., Checheir N.C., Chulkov V.S., Cluver C.A., Crawford C.F., Gbinigie O.A., Glogowska M., Goodlife A., Gough K.L., Green J.R., Gul F., Haggerty L., Hall D.R., and Hallman M.

Abstract

Objective: To develop a core outcome set for pre-eclampsia. Design(s): Consensus development study. Setting(s): International. Population: Two hundred and eight-one healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated. Method(s): Modified Delphi method and Modified Nominal Group Technique. Result(s): A long-list of 116 potential core outcomes was developed by combining the outcomes reported in 79 pre-eclampsia trials with those derived from thematic analysis of 30 in-depth interviews of women with lived experience of pre-eclampsia. Forty-seven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, small-for-gestational-age, neonatal mortality, seizures, admission to neonatal unit required and respiratory support. Conclusion(s): The core outcome set for pre-eclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies. Tweetable abstract: 281 healthcare professionals, 41 researchers and 110 women have developed #preeclampsia core outcomes @HOPEoutcomes @jamesmnduffy. [Correction added on 29 June 2020, after first online publication: the order has been corrected.].Copyright © 2020 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetr

Published
2021

33. Standardising definitions for the pre-eclampsia core outcome set: A consensus development study.

Author

Donald F., Morgan L., Moulson A., Mughal F., Mundle S.R., Munoz M.A., Murray E., Nagata C., Nair A.S., Nakimuli A., Nath G., Newport R.S., Oakeshott P., Ochoa-Ferraro M.R., Odendaal H., Ohkuchi A., Oliveira L., Ortiz-Panozo E., Oudijk M.A., Oygucu S.E., Paech M.J., Painter R.C., Parry C.L., Payne B.A., Pearson E.L., Phupong V., Pickett N., Pickles K.A., Plumb L.K., Prefumo F., Preston R., Ray J.G., Rayment J., Regan L.V., Rey E., Robson E.J., Rubin A.N., Rubio-Romero J.A., Rull K., Sass N., Sauve N., Savory N.A., Scott J.R., Seaton S.E., Seed P.T., Shakespeare J.M., Shand A.W., Sharma S., Shaw T.Y., Smedley K.L., Smith D., Smith Conk A., Soward D., Stepan H., Stroumpoulis K., Surendran A., Takeda S., Tan L., Theriot B.S., Thomas H.F., Thompson K., Thompson P.I., Thompson M.J., Toms L., Torney K.L.H.T., Treadwell J.S., Tucker K.L., Turrentine M.A., Van Hecke O., Van Oostwaard M.F., Vasquez D.N., Vaughan D.J.A., Vinturache A., Walker J., Wardle S.P., Wasim T., Waters J.H., Whitehead C.L., Wolfson A., Yeo S., Zermansky A.G., Mol B., Duffy J.M.N., Cairns A.E., Magee L.A., von Dadelszen P., van 't Hooft J., Gale C., Brown M., Chappell L.C., Grobman W.A., Fitzpatrick R., Karumanchi S.A., Lucas D.N., Stark M., Thangaratinam S., Wilson M.J., Williamson P.R., Ziebland S., McManus R.J., Abalos E.J., Adamson C.C.D., Akadri A.A., Akturk Z., Allegaert K., Angel-Muller E., Antretter J., Ashdown H.F., Audibert F., Auger N., Aygun C., Babic I., Bagga R., Baker J.M., Beebeejaun Y., Bhakta P., Bhandari V., Bhattacharya S., Blanker M.H., Bloomfield F.H., Bof A., Brennan S.M., Broekhuijsen K., Broughton Pipkin F., Browne J.L., Browning R.M., Bull J.W., Butt A., Button D., Campbell J.P., Campbell D.M., Carbillon L., Carthy S., Casely E., Cave J.A., Cecatti J.G., Chamillard M.E., Chassard D., Checheir N.C., Chulkov V.S., Cluver C.A., Crawford C.F., Daly M.C., Darmochwal-Kolarz D.A., Davies R.E., Davies M.W., Dawson J.S., Dobson N., Dodd C.N., Duley L., Epstein-Mares J., Erez O., Evans E., Farlie R.N., Ferris A.V., Frankland E.M., Freeman D.J., Gainder S., Ganzevoort W., Gbinigie O.A., Gerval M.-O., Ghosh S.K., Gingel L.J., Glogowska M., Goodlife A., Gough K.L., Green J.R., Gul F., Haggerty L., Hall D.R., Hallman M., Hamilton L.M., Hammond S.J., Harlow S.D., Hays K.E., Hickey S.C., Higgins M., Hinton L., Hobson S.R., Hogg M.J., Hollands H.J., Homer C.S.E., Hoodbhoy Z., Howell P., Huppertz B., Husain S., Jacoby S.D., Jacqz-Aigrain E., Jenkins G., Jewel D., Johnson M.J., Johnston C.L., Jones P.M., Kantrowitz-Gordon I., Khan R.-U., Kirby L.J., Kirk C., Knight M., Korey M.T., Lee G.J., Lee V.W., Levene L.S., Londero A.P., Lust K.M., MacKenzie V., Malha L., Mattone M., McCartney D.E., McFadden A., McKinstry B.H., Middleton P.F., Mills D.J., Mistry H.D., Mitchell C.A., Mockler J.C., Molsher S.-A., Monast E.S., Moodley J., Mooij R., Moore E.L., Donald F., Morgan L., Moulson A., Mughal F., Mundle S.R., Munoz M.A., Murray E., Nagata C., Nair A.S., Nakimuli A., Nath G., Newport R.S., Oakeshott P., Ochoa-Ferraro M.R., Odendaal H., Ohkuchi A., Oliveira L., Ortiz-Panozo E., Oudijk M.A., Oygucu S.E., Paech M.J., Painter R.C., Parry C.L., Payne B.A., Pearson E.L., Phupong V., Pickett N., Pickles K.A., Plumb L.K., Prefumo F., Preston R., Ray J.G., Rayment J., Regan L.V., Rey E., Robson E.J., Rubin A.N., Rubio-Romero J.A., Rull K., Sass N., Sauve N., Savory N.A., Scott J.R., Seaton S.E., Seed P.T., Shakespeare J.M., Shand A.W., Sharma S., Shaw T.Y., Smedley K.L., Smith D., Smith Conk A., Soward D., Stepan H., Stroumpoulis K., Surendran A., Takeda S., Tan L., Theriot B.S., Thomas H.F., Thompson K., Thompson P.I., Thompson M.J., Toms L., Torney K.L.H.T., Treadwell J.S., Tucker K.L., Turrentine M.A., Van Hecke O., Van Oostwaard M.F., Vasquez D.N., Vaughan D.J.A., Vinturache A., Walker J., Wardle S.P., Wasim T., Waters J.H., Whitehead C.L., Wolfson A., Yeo S., Zermansky A.G., Mol B., Duffy J.M.N., Cairns A.E., Magee L.A., von Dadelszen P., van 't Hooft J., Gale C., Brown M., Chappell L.C., Grobman W.A., Fitzpatrick R., Karumanchi S.A., Lucas D.N., Stark M., Thangaratinam S., Wilson M.J., Williamson P.R., Ziebland S., McManus R.J., Abalos E.J., Adamson C.C.D., Akadri A.A., Akturk Z., Allegaert K., Angel-Muller E., Antretter J., Ashdown H.F., Audibert F., Auger N., Aygun C., Babic I., Bagga R., Baker J.M., Beebeejaun Y., Bhakta P., Bhandari V., Bhattacharya S., Blanker M.H., Bloomfield F.H., Bof A., Brennan S.M., Broekhuijsen K., Broughton Pipkin F., Browne J.L., Browning R.M., Bull J.W., Butt A., Button D., Campbell J.P., Campbell D.M., Carbillon L., Carthy S., Casely E., Cave J.A., Cecatti J.G., Chamillard M.E., Chassard D., Checheir N.C., Chulkov V.S., Cluver C.A., Crawford C.F., Daly M.C., Darmochwal-Kolarz D.A., Davies R.E., Davies M.W., Dawson J.S., Dobson N., Dodd C.N., Duley L., Epstein-Mares J., Erez O., Evans E., Farlie R.N., Ferris A.V., Frankland E.M., Freeman D.J., Gainder S., Ganzevoort W., Gbinigie O.A., Gerval M.-O., Ghosh S.K., Gingel L.J., Glogowska M., Goodlife A., Gough K.L., Green J.R., Gul F., Haggerty L., Hall D.R., Hallman M., Hamilton L.M., Hammond S.J., Harlow S.D., Hays K.E., Hickey S.C., Higgins M., Hinton L., Hobson S.R., Hogg M.J., Hollands H.J., Homer C.S.E., Hoodbhoy Z., Howell P., Huppertz B., Husain S., Jacoby S.D., Jacqz-Aigrain E., Jenkins G., Jewel D., Johnson M.J., Johnston C.L., Jones P.M., Kantrowitz-Gordon I., Khan R.-U., Kirby L.J., Kirk C., Knight M., Korey M.T., Lee G.J., Lee V.W., Levene L.S., Londero A.P., Lust K.M., MacKenzie V., Malha L., Mattone M., McCartney D.E., McFadden A., McKinstry B.H., Middleton P.F., Mills D.J., Mistry H.D., Mitchell C.A., Mockler J.C., Molsher S.-A., Monast E.S., Moodley J., Mooij R., and Moore E.L.

Abstract

Objectives: To develop consensus definitions for the core outcome set for pre-eclampsia. Study design: Potential definitions for individual core outcomes were identified across four formal definition development initiatives, nine national and international guidelines, 12 Cochrane systematic reviews, and 79 randomised trials. Eighty-six definitions were entered into the consensus development meeting. Ten healthcare professionals and three researchers, including six participants who had experience of conducting research in low- and middle-income countries, participated in the consensus development process. The final core outcome set was approved by an international steering group. Result(s): Consensus definitions were developed for all core outcomes. When considering stroke, pulmonary oedema, acute kidney injury, raised liver enzymes, low platelets, birth weight, and neonatal seizures, consensus definitions were developed specifically for low- and middle-income countries because of the limited availability of diagnostic interventions including computerised tomography, chest x-ray, laboratory tests, equipment, and electroencephalogram monitoring. Conclusion(s): Consensus on measurements for the pre-eclampsia core outcome set will help to ensure consistency across future randomised trials and systematic reviews. Such standardization should make research evidence more accessible and facilitate the translation of research into clinical practice. Video abstract can be available at: www.dropbox.com/s/ftrgvrfu0u9glqd/6.%20Standardising%20definitions%20in%20teh%20pre-eclampsia%20core%20outcome%20set%3A%20a%20consensus%20development%20study.mp4?dl=0.Copyright © 2020 International Society for the Study of Hypertension in Pregnancy

Published
2020

35. Can a community empowerment intervention improve health and wellbeing in a post-industrial UK town?

Author

Coan, S, Woodward, J, South, J, Bagnall, A-M, Southby, K, Button, D, Trigwell, J, Coan, S, Woodward, J, South, J, Bagnall, A-M, Southby, K, Button, D, and Trigwell, J

Abstract

Background The ‘Local People’ programme operates in 29 UK communities experiencing disadvantage and economic stressors that impact on population wellbeing. The programme uses a community empowerment approach to increase social connections, and collective control, improve health, and reduce inequalities. This links to SDGs 3 and 11. Mechanisms include a decision-making group led by residents, a project lead, funding, and support from a national charity. Methods A mixed method evaluation was conducted (2017-19) to identify processes and assess outcomes and impacts. This presentation outlines the findings from five in-depth qualitative case studies (c140 interviews) with emphasis on one post-industrial UK town suffering from the effects of industrial decline. A within case and cross case qualitative analysis was undertaken using a thematic framework. Results Priorities set by local areas focused on increasing community involvement and connections between people. A wide range of activities took place including regular classes and community events. The five case studies found strong qualitative evidence of increased social connectedness, community spirit and a sense of purpose, along with the area becoming a better place to live. People involved in project delivery gained confidence and skills, improved their wellbeing and gained a sense of control. There is, as yet, limited evidence that increased involvement has influenced the wider determinants of health. In the post-industrial town, people’s social networks expanded, enriching their lives and providing missed companionship. Participants in the programme reported improved mental and physical health, as well as increased confidence and skills. Involvement gave a voice to marginalised older people in the area. Conclusion Empowering communities and putting residents in control can lead to improvements in connectedness and some aspects of health and wellbeing, even in post-industrial towns facing considerable and complex

Published
2020

39. Complexity and Community Context: Learning from the Evaluation Design of a National Community Empowerment Programme

Author

South, J, Button, D, Quick, A, Bagnall, A-M, Trigwell, J, Woodward, J, Coan, S, Southby, K, South, J, Button, D, Quick, A, Bagnall, A-M, Trigwell, J, Woodward, J, Coan, S, and Southby, K

Abstract

Community empowerment interventions, which aim to build greater individual and community control over health, are shaped by the community systems in which they are implemented. Drawing on complex systems thinking in public health research, this paper discusses the evaluation approach used for a UK community empowerment programme focused on disadvantaged neighbourhoods. It explores design choices and the tension between the overall enquiry questions, which were based on a programme theory of change, and the varied dynamic socio-cultural contexts in intervention communities. The paper concludes that the complexity of community systems needs to be accounted for through in-depth case studies that incorporate community perspectives.

Published
2019

40. Herz-Kreislauf-Stillstand

Author

Gerber, Christof, Button, Daniel, et al, Gerber, C ( Christof ), Button, D ( Daniel ), et al, ( ), Kaserer, Alexander, Gerber, Christof, Button, Daniel, et al, Gerber, C ( Christof ), Button, D ( Daniel ), et al, ( ), and Kaserer, Alexander

Published
2019

43. Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Author

Bath, Philip M, primary, Woodhouse, Lisa J, additional, Appleton, Jason P, additional, Beridze, Maia, additional, Christensen, Hanne, additional, Dineen, Robert A, additional, Duley, Lelia, additional, England, Timothy J, additional, Flaherty, Katie, additional, Havard, Diane, additional, Heptinstall, Stan, additional, James, Marilyn, additional, Krishnan, Kailash, additional, Markus, Hugh S, additional, Montgomery, Alan A, additional, Pocock, Stuart J, additional, Randall, Marc, additional, Ranta, Annemarei, additional, Robinson, Thompson G, additional, Scutt, Polly, additional, Venables, Graham S, additional, Sprigg, Nikola, additional, Christensen, L M, additional, Bentsen, L, additional, Krarup Hansen, C, additional, Thomsen, T T, additional, Kruuse, C, additional, Jensen, H H, additional, Hansen, S S, additional, Petrovic, V, additional, Beridze, N, additional, Kakabadze, N, additional, Kherkheulidze, T, additional, Kakabadze, D, additional, Toidze, I, additional, Lobjanidze, N, additional, Akiashvili, N, additional, Tevdoradze, A, additional, Khizanishvili, N, additional, Tsanava, T, additional, Taylor, R, additional, Iniesta, I, additional, Kok, J, additional, Duignan, J, additional, Funnell, M, additional, Cariga, P, additional, Rodriguez, M, additional, Watson, I J, additional, Tennant, S, additional, Macleod, M, additional, Furnace, J, additional, Gow, H, additional, Irvine, J, additional, Joyson, A, additional, Nelson, S, additional, Taylor, V, additional, Smith, M, additional, Bellfield, R, additional, Hairsine, B, additional, Davies, R, additional, Dodd, A, additional, Corrigan, J, additional, Doherty, M, additional, Ahmed, A, additional, Denniss, C, additional, Johnson-Holland, S, additional, Kay, K A, additional, Palau, R Icart, additional, Auld, G, additional, Daboo, P, additional, Erande, R, additional, Grimwood, G, additional, Hove, D, additional, Howaniec, L, additional, Redjep, O, additional, Rangasamay, R, additional, Butt, G, additional, Sandler, D, additional, Reddan, J, additional, Stafford, S, additional, McIlmoyle, J, additional, Maguire, S, additional, Murphy, P, additional, Chambers, J, additional, Guthrie, L, additional, Osborn, M, additional, Steele, A, additional, Burn, M, additional, Benford, A, additional, Misra, A, additional, Hilton, D, additional, O'Brien, E, additional, Amis, E, additional, Finlay, S, additional, Mitchell, J, additional, Geraghty, O, additional, Harvey, K, additional, Hazel, B, additional, Mashate, S, additional, Wilding, P, additional, Sajid, M, additional, Ball, M, additional, Gascoyne, R, additional, Sivakumar, R, additional, Wright, A, additional, Chatterjee, K, additional, Booth, S, additional, Eccleson, H, additional, Kelly, C, additional, Leason, S, additional, Perkins, C, additional, Bruce, D, additional, Brown, E, additional, Clayton, S, additional, Garside, M, additional, Rogers, G, additional, Lawrence, E, additional, Mahmood, S, additional, Watchurst, C, additional, Chadha, D, additional, Glover, L, additional, Holford, L, additional, Smith, K, additional, Walstow, D, additional, Williams, R, additional, O'Shea, L, additional, Goodsell, J, additional, Athulathmudali, C, additional, Barbon, E, additional, Namushi, R, additional, Jacob, P, additional, Johnson, L, additional, Morse, D, additional, McGhee, C, additional, Speirs, O, additional, Atkinson, S, additional, Peacocke, A, additional, Langhorne, P, additional, Graham, R, additional, Wright, F, additional, McAlpine, C, additional, Ravindrane, A, additional, Bajoriene, M, additional, Matter, L, additional, Windebank, S, additional, Giallombardo, E, additional, Dellafera, D, additional, Eglinton, C, additional, Wilson, J, additional, Broughton, D, additional, Chapman, K, additional, Dixon, L, additional, Zaidi, M, additional, Ayes, K, additional, Kessell, J, additional, Manawadu, D, additional, Adegbaju, O, additional, Aeron-Thomas, J, additional, Anderson, K, additional, Brigden, A, additional, Cattermole, E, additional, Good, J, additional, Hassan, S, additional, Khoromana, E, additional, Lee-Carbon, L, additional, Marks, K, additional, Mckenzie, E, additional, Sikondari, N, additional, Cooper, M, additional, Whysall, K, additional, Wynter, I, additional, Bamford, J, additional, Hassan, A, additional, Wanklyn, P, additional, Kambafwile, M, additional, Makawa, L, additional, Waugh, D, additional, Veraque, E, additional, Soliman, MGG, additional, Arif, S, additional, Brown, R, additional, Butler, S, additional, Hewitt, C, additional, Hindle, J, additional, Pusalkar, A, additional, Beadle, H, additional, Chan, K, additional, Siddiqui, M, additional, Dangri, P, additional, Buddha, S, additional, Asokanathan, A, additional, Mistri, A, additional, Eveson, D, additional, Musarrat, K, additional, Manning, L, additional, Anand, S, additional, Christian, P, additional, Khan, S, additional, Patel, C, additional, Sein, M, additional, Banns, J, additional, Gibson, E, additional, Gordon, T, additional, Gruenbeck, Y, additional, Wong, S, additional, Datta, P, additional, Bateman, G, additional, Jackson, L, additional, Needle, A, additional, Duodu, Y, additional, Oliver, R, additional, Padilla-Harris, C, additional, Barber, M, additional, Esson, D, additional, Brodie, F, additional, McInnes, C, additional, Fotherby, K, additional, Butler, D, additional, Morgan, D, additional, Preece, K, additional, Willberry, A, additional, Dent, M, additional, Hammonds, F, additional, Hunt, J, additional, Vernon, C, additional, O'Kane, D, additional, Faola, F, additional, Lai, P, additional, O'Callaghan, J, additional, Smith, C, additional, Price, C, additional, Lakey, R, additional, Riddell, V, additional, Smith, A, additional, Storey, G, additional, Munshi, S, additional, Buck, A, additional, Clarke, J, additional, Gilzeane, N, additional, Godfrey, M, additional, Keshvara, R, additional, Richardson, C, additional, Roffe, J, additional, Ryan, L, additional, Shelton, F, additional, Sunman, W, additional, Tittle, A, additional, Tomlinson, J, additional, Whittamore, K, additional, Wilkes, G, additional, Owusu-Agyei, P, additional, Temple, N, additional, Mangion, D, additional, Hardwick, A, additional, Netherton, K, additional, Nor, A Mohd, additional, Hyams, B, additional, Norman, S, additional, Persad, N, additional, Ragab, S, additional, Dickson, C, additional, Dube, J, additional, Jinks, E, additional, Knops, K, additional, Wadams, B, additional, Ali, K, additional, Gaylard, J, additional, Spurling, G, additional, Sztriha, L, additional, Ajao, T, additional, Alao, M, additional, Chan, F K, additional, Webster, P, additional, Howard, P, additional, Dobson, T J, additional, Hyatt, L, additional, Sims, D, additional, Cunningham, J, additional, Esisi, B, additional, Cassidy, T, additional, Bokhari, M, additional, McClelland, B, additional, Mokoena, B, additional, Gunathilagan, G, additional, Jones, S, additional, Reader, M, additional, Thomas, G, additional, Tilby, S, additional, Findlay, P, additional, Barrett, F, additional, Leslie, F, additional, Ross, S, additional, Shread, I, additional, Okwera, J, additional, Howe, J, additional, Harrington, F, additional, Courtauld, G, additional, Schofield, C, additional, Donnelly, R, additional, Maddula, M, additional, Scott, J, additional, Beavan, J, additional, Muhidden, K, additional, Memon, I, additional, Clarke, M, additional, Hedstrom, A, additional, Mills, L, additional, Hemsley, A, additional, Bowring, A, additional, Boxall, L, additional, Kingwell, H, additional, Keenan, S, additional, Roughan, C, additional, Manoj, A, additional, Cox, P, additional, Fletcher, G, additional, Lopez, P, additional, Emsley, H, additional, Gregary, B, additional, McLoughlin, A, additional, Raj, S, additional, Roffe, C, additional, Abano, N, additional, Barry, A, additional, Butler, A, additional, Carpio, R, additional, Castro, K, additional, Finney, K, additional, Gomm, S, additional, Hiden, J, additional, Grocott, J, additional, Lyjko, S, additional, Maguire, H, additional, Remegoso, A, additional, Sanyal, R, additional, Stevens, S, additional, Natarajan, I, additional, Chembala, J, additional, Muddegowda, G, additional, Warusevitane, A, additional, Blight, A, additional, Balazikova, O, additional, Lawlor, C, additional, Shaw, L, additional, Button, D, additional, Howcroft, D, additional, Lucas, S, additional, Madigan, B, additional, McCann, S, additional, Dixit, A, additional, Barkat, A, additional, Davis, J, additional, Fawcett, M, additional, Finlay, L, additional, Guy, H, additional, Hays, C, additional, Hogg, V, additional, Horsley, E, additional, Hubbuck, C, additional, Pringle, C, additional, Stevenson, C, additional, Storey, K, additional, Thompson, T, additional, Woodward, S, additional, Banerjee, A, additional, Allcock, C, additional, Merotra, S, additional, Douglass, C, additional, Campbell, E, additional, Jarapa, R, additional, Johnes, M, additional, Keaveney, C, additional, Marsden, T, additional, Naing, Z, additional, Perez, J, additional, Shaw, K, additional, Black, T, additional, Anthony, A, additional, Clarke, C, additional, Paterson, J, additional, Deighton, K, additional, Temlett, E, additional, Blank, C, additional, Doyle, C, additional, Duty, S, additional, Gill, K, additional, Harkness, K, additional, Kamara, C, additional, Richards, E, additional, Elfandi, K, additional, Guyler, P, additional, Harman, P, additional, Khuoge, C, additional, Kunhunny, S, additional, Tysoe, S, additional, Moynihan, B, additional, Adedoyin, T, additional, Chopra, N, additional, Dayal, N, additional, Ghatala, R, additional, Jeyaraj, N, additional, Jones, I, additional, Kennedy, F, additional, Kerin, L, additional, Khanom, N, additional, Lewis, S, additional, Maheswaran, S, additional, Montague, L, additional, Niemierko, M, additional, O'Reilly, J, additional, Trippier, S, additional, Watson, F, additional, Wilkinson, P, additional, Young, E, additional, Dizayee, K, additional, Cochrane, H, additional, O'Connell, J, additional, Mokoena, L, additional, Osborne, E, additional, Nair, A, additional, Greig, J, additional, Jenkins, C, additional, Powell, J, additional, Price, F, additional, Chowdhury, M, additional, Brixey, S, additional, Hunt, L, additional, Rands, N, additional, Rose, G, additional, Stoddart, S, additional, Srinivasan, M, additional, Motherwell, N, additional, Shekhar, R, additional, Fuller, T, additional, Lankester, A, additional, Lingwood, P, additional, Rankin, C, additional, Webb, H, additional, Jupp, B, additional, Bell, J, additional, Hann, G, additional, Longland, B, additional, Ovington, C, additional, Bhaskaran, B, additional, Ayres, G, additional, Bailey, C, additional, Bearne, H, additional, Buxton, J, additional, Fitzell, P, additional, Hilaire, C, additional, Kelly, D, additional, Szabo, S, additional, Tomlin, D, additional, Gamble, E, additional, Charles, B, additional, Kumar, R, additional, Fluskey, T, additional, Mellor, Z, additional, Peters, J, additional, Sutton, V, additional, Kenton, A, additional, Martin, I, additional, Nyabadza, S, additional, Ghosh, S, additional, Henry, M, additional, Kumar, B, additional, Ambulo, C, additional, Crawford, S, additional, Nozedar, T, additional, Platton, M, additional, Cvoro, V, additional, Couser, M, additional, McCormick, K, additional, Wilkinson, D, additional, Javaid, K, additional, Hurdowar, S, additional, Attygalle, T, additional, Sundayi, S, additional, Orugun, O, additional, Crowther, H, additional, Jolly, R, additional, Poultney, U, additional, Azim, A, additional, Krasinska-Chavez, M, additional, White, J, additional, Sengupta, N, additional, Margalef, J, additional, Metiu, M G, additional, Meenakshisundaram, S, additional, Dealing, S, additional, Hargroves, D, additional, Beranova, E, additional, Cowie, L, additional, Rudenko, H, additional, Thomson, A, additional, Verrion, A, additional, Rashed, K, additional, Board, S, additional, Buckley, C, additional, Hayward, D, additional, Jenkins, K, additional, Keeling, E, additional, Rowland-Axe, R, additional, Vickers, C, additional, Wood, D, additional, Lehman, A, additional, Patel, M, additional, Russell, H, additional, Rehman, H, additional, Forrest, D, additional, and Farren, P, additional

Published
2018
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47. Clinical evaluation of the FloTrac/VigileoTM system and two established continuous cardiac output monitoring devices in patients undergoing cardiac surgery†‡

Author

Button, D., Weibel, L., Reuthebuch, O., Genoni, M., Zollinger, A., Hofer, C. K., Button, D., Weibel, L., Reuthebuch, O., Genoni, M., Zollinger, A., and Hofer, C. K.

Abstract

Background Assessment of cardiac output (CO) by the FloTrac/Vigileo™ system may offer a less invasive means of determining the CO than either the pulmonary artery catheter (PAC) or the PiCCOplus™ system. The aim of this study was to compare CO measurements made using the FloTrac/Vigileo™ system with upgraded software (FCO, Edwards Lifesciences, Irvine CA, USA), the PiCCOplus™ system (PCO, Pulsion Medical Systems, Munich, Germany) and continuous CO monitoring using a PAC (CCO; Vigilance™ monitoring, Edwards Lifesciences, Irvine CA, USA) with intermittent pulmonary artery thermodilution (ICO). The study was conducted in patients undergoing elective cardiac surgery. Methods Thirty-one patients with preserved left ventricular function were enrolled. CCO, FCO, and PCO were recorded in the perioperative period at six predefined time points after achieving stable haemodynamic conditions; ICO was determined from the mean of three bolus injections. Bland-Altman analysis was used to compare CCO, FCO, and PCO with ICO. Results Bland-Altman analysis revealed a comparable mean bias and limits of agreement for all tested continuous CO monitoring devices using ICO as reference method. Agreement for all devices decreased in the postoperative period. Conclusion The performance of the FloTrac/Vigileo™ system, the PiCCOplus™, and the Vigilance™ CCO monitoring for CO measurement were comparable when tested against intermittent thermodilution in patients undergoing elective cardiac surgery

Published
2017

48. Estimated GFR and the Effect of Intensive Blood Pressure Lowering after Acute Intracerebral Hemorrhage.

Author

Fischer R., Gama G., Fonseca L., Moreira G., Veloso L.M., Pinheiro D., Paredes L., Rozeira C., Gregorio T., Segura Martin T., Ayo O., Garcia-Garcia J., Feria Vilar I., Gomez Fernandez I., Amaro S., Urra X., Obach V., Cervera A., Silva Y., Serena J., Castellanos M., Terceno M., Van Eendenburg C., Weck A., Findling O., Ludi R., Warburton E.A., Day D., Butler N., Bumanlag E., Caine S., Steele A., Osborn M., Dodd E., Murphy P., Esisi B., Brown E., Hayman R., Baliga V.K.V., Minphone M., Kennedy J., Reckless I., Pope G., Teal R., Michael K., Manawadu D., Kalra L., Lewis R., Mistry B., Cattermole E., Hassan A., Mandizvidza L., Bamford J., Brooks H., Bedford C., Whiting R., Baines P., Hussain M., Harvey M., Fotherby K., McBride S., Bourke P., Morgan D., Jennings-Preece K., Price C., Huntley S., Riddell V.E., Storey G., Lakey R.L., Subramanian G., Jenkinson D., Kwan J., David O., Tiwari D., James M., Keenan S., Eastwood H., Shaw L., Kaye P., Button D., Madigan B., Williamson D., Dixit A., Davis J., Hossain M.O., Ford G.A., Parry-Jones A., O'Loughlin V., Jarapa R., Naing Z., Lovelock C., O'Reilly J., Khan U., Bhalla A., Rudd A., Birns J., Werring D.J., Law R., Perry R., Jones I., Erande R., Roffe C., Natarajan I., Ahmad N., Finney K., Lucas J., Mistri A., Eveson D., Marsh R., Haunton V., Fugate J.E., Lepore S.W., Zheng D., Sato S., Arima H., Heeley E., Delcourt C., Cao Y., Chalmers J., Anderson C.S., Davis S., Huang Y., Lavados P., Neal B., Parsons M.W., Lindley R., Morgenstern L., Robinson T., Stapf C., Tzourio C., Wang J.G., Chen S., Chen X.Y., Cui L., Liu Z., Lu C., Wang J., Wu S., Xu E., Yang Q., Zhang C., Zhang J., Beer R., Schmutzhard E., Redondo P., Kaste M., Soinne L., Tatlisumak T., Wartenberg K., Ricci S., Klijn K., Azevedo E., Chamorro A., Arnold M., Fischer U., Kaul S., Pandian J., Boyini H., Singh S., Rabinstein A.A., Estol C., Silva G., Olavarria V.V., Robinson T.G., Simes R.J., Bousser M.-G., Hankey G., Jamrozik K., Johnston S.C., Li S., Bailey K., Cheung T., Chintapatla S., Ducasse E., Erho T., Hata J., Holder B., Knight E., Leroux M., Sasse T., Odgers E., Walsh R., Wolfowicz Z., Chen G., Fuentes S., Peng B., Schneble H.-M., Wang M.-X., Billot L., Heritier S., Li Q., Woodward M., Abimbola S., Anderson S., Chan E., Cheng G., Chmielnik P., Leighton S., Liu J.-Y., Rasmussen B., Saxena A., Tripathy S., Armenis M., Baig M.A., Naidu B., Starzec G., Steley S., Moles A., Ruiz A., Zimmermann M., Marinho J., Alves S., Angelim R., Araujo J., Kawakami L., Bustos C., Gonzalez F., Munoz Venturelli P., Chen X., Jia R., Li N., Qu S., Shu Y., Song A., Sun J., Xiao J., Zhao Y., Huang Q., Vicaut E., Chamam A., Viaud M.-C., Dert C., Fiedler U., Jovis V., Kabla S., Marchand S., Pena A., Mallikarjuna K., Hasan N., Berge E., Sandset E.C., Forarsveen A.S., Richardson D., Kumar T., Lewin S., Poulter N., Field J., Anjum A., Wilson A., Perelmuter H., Agarie A.M., Barboza A.G., Recchia L.A., Miranda I.F., Rauek S.G., Duplessis R.J., Dewey H., Walker L., Petrolo S., Bladin C., Sturm J., Crimmins D., Griffiths D., Schutz A., Zenteno V., Miteff F., Spratt N., Kerr E., Levi C.R., Phan T.G., Ma H., Sanders L., Moran C., Wong K., Read S., Henderson R., Wong A., Hull R., Skinner G., Hand P., Yan B., Tu H., Campbell B., Blacker D.J., Wijeratne T., Pathirage M., Jasinararchchi M., Matkovic Z., Celestino S., Gruber F., Vosko M.R., Diabl E., Rathmaier S., Pfausler B., Helbok R., Fazekas F., Poltrum B., Zechner B., Trummer U., Rutgers M.P., Peeters A., Dusart A., Duray M.-C., Parmentier C., Ferrao-Santos S., Brouns R., De Raedt S., De Smedt A., Vanhooff R.-J., De Keyser J., Martins S.C.O., De Almeida A.G., Broudani R., Titton N.F., De Freitas G.R., Cardoso F.M., Giesel L.M., Lima N.A., Ferraz De Almeida A.C., Gomes R.B., Borges Dos Santos T.S., Veloso Soares E.M., Neto O.L.A., Silva G.S., Gomes D.L., De Carvalho F.A., Miranda M., Marques A., Zetola V.F., De Matia G., Lange M.C., Montes J., Reccius A., Soto A., Rivas R., Klapp C., Illanes S., Aguilera C., Castro A., Figueroa C., Benavides J., Salamanca P., Concha M.C., Pajarito J., Araya P., Guerra F., Li Y., Liu G., Wang B., Chong Y., He M., Wang L., Liu J., Zhang X., Lai C., Jiang H., Cui S., Tao Q., Zhang Y., Yao S., Xu M., Xiao H., Hu J., Tang J., Ji H., Jiang M., Yu F., Yang X., Guo X., Wang Y., Wu L., Gao Y., Sun D., Huang X., Liu L., Li P., Jiang Y., Li H., Lu H., Zhou J., Yuan C., Qi X., Qiu F., Qian H., Wang W., Sun W., Li F., Liu R., Peng Q., Ren Z., Fan C., Wang H., Wang T., Shi F., Duan C., Chen Z., Tan X., Zhao Z., Chen J., Han T., Zhang L., Hu Q., Hou Q., Zhao X., Zeng G., Ma L., Wang F., Guo Z., Fu Y., Song Y., Tai L., Liu X., Su X., Yang Y., Dong R., Xu Y., Tian S., Cheng S., Su L., Xie X., Xu T., Geng D., Yan X., Fan H., Zhao N., Wang S., Yang J., Yan M., Li L., Li Z., Xu X., Lian Y., Sun H., Liu D., Wang N., Tang Q., Han Z., Feng L., Cui Y., Tian J., Chang H., Sun X., Liu C., Wen Z., Lin Q., Sun L., Hu B., Zou M., Bao Q., Lin X., Zhao L., Tian X., Wang X., Li X., Hao L., Duan Y., Wang R., Wei Z., Ren S., Ren H., Dong Y., Cheng Y., Liu W., Han J., Zhang Z., Zhu J., Qian J., Sun Y., Liu K., Long F., Peng X., Zhang Q., Yuan Z., Wang C., Huang M., He P., You Y., Xia J., Zhou L., Hou Y., Qi Y., Mei L., Lu R., Ping L., Zhou S., Zhang S., Zou R., Guo J., Li M., Wei W., Curtze S., Saarela M., Strbian D., Scheperjans F., De Broucker T., Henry C., Cumurciuc R., Ibos-Auge N., Zeghoudi A.-C., Pico F., Dereeper O., Simian M.-C., Boisselier C., Mahfoud A., Timsit S., Merrien F.M., Guillon B., Sevin M., Herisson F., Magne C., Ameri A., Cret C., Stefanizzi S., Klapzcynski F., Denier C., Sarov-Riviere M., Reiner P., Mawet J., Herve D., Buffon F., Touze E., Domigo V., Lamy C., Calvet D., Pasquini M., Alamowitch S., Favrole P., Muresan I.-P., Crozier S., Rosso C., Pires C., Leger A., Deltour S., Cordonnier C., Henon H., Rossi C., Zuber M., Bruandet M., Tamazyan R., Join-Lambert C., Juettler E., Krause T., Maul S., Endres M., Jungehulsing G.J., Hennerici M., Griebe M., Sauer T., Knoll K., Huber R., Knauer K., Knauer C., Raubold S., Schneider H., Hentschel H., Lautenschlager C., Schimmel E., Dzialowski I., Foerch C., Lorenz M., Singer O., Meyer Dos Santos I.M.R., Hartmann A., Hamann A., Schacht A., Schrader B., Teichmann A., Wartenberg K.E., Mueller T.J., Jander S., Gliem M., Boettcher C., Rosenkranz M., Beck C., Otto D., Thomalla G., Cheng B., Wong K.S., Leung T.W., Soo Y.O.Y., Prabhakar S., Kesavarapu S.R., Gajjela P.K., Chenna R.R., Ummer K., Basheer M., Andipet A., Jagarlapudi M.K.M., Mohammed A.U.R., Pawar V.G., Eranki S.S.K., Singh Y., Akhtar N., Borah N.C., Ghose M., Choudhury N., Ichaporia N.R., Shendge J., Khese S., Pamidimukkala V., Inbamuthaiah P., Nuthakki S.R., Tagallamudi N.M.R., Gutti A.K., Khurana D., Kesavarapu P., Jogi V., Garg A., Samanta D., Sarma G.R.K., Nadig R., Mathew T., Anandan M.A., Caterbi E., Zini A., Cavazzuti M., Casoni F., Pentore R., Falzone F., Mazzoli T., Greco L.M., Menichetti C., Coppola F., Cenciarelli S., Gallinella E., Mattioni A., Condurso R., Sicilia I., Zampolini M., Corea F., Barbi M., Proietti C., Toni D., Pieroni A., Anzini A., Falcou A., Demichele M., Klijn C.J.M., Tveiten A., Thortveit E.T., Pettersen S., Holand N., Hitland B., Johnsen S.H., Eltoft A., Wasay M., Kamal A., Iqrar A., Ali L., Begum D., Fischer R., Gama G., Fonseca L., Moreira G., Veloso L.M., Pinheiro D., Paredes L., Rozeira C., Gregorio T., Segura Martin T., Ayo O., Garcia-Garcia J., Feria Vilar I., Gomez Fernandez I., Amaro S., Urra X., Obach V., Cervera A., Silva Y., Serena J., Castellanos M., Terceno M., Van Eendenburg C., Weck A., Findling O., Ludi R., Warburton E.A., Day D., Butler N., Bumanlag E., Caine S., Steele A., Osborn M., Dodd E., Murphy P., Esisi B., Brown E., Hayman R., Baliga V.K.V., Minphone M., Kennedy J., Reckless I., Pope G., Teal R., Michael K., Manawadu D., Kalra L., Lewis R., Mistry B., Cattermole E., Hassan A., Mandizvidza L., Bamford J., Brooks H., Bedford C., Whiting R., Baines P., Hussain M., Harvey M., Fotherby K., McBride S., Bourke P., Morgan D., Jennings-Preece K., Price C., Huntley S., Riddell V.E., Storey G., Lakey R.L., Subramanian G., Jenkinson D., Kwan J., David O., Tiwari D., James M., Keenan S., Eastwood H., Shaw L., Kaye P., Button D., Madigan B., Williamson D., Dixit A., Davis J., Hossain M.O., Ford G.A., Parry-Jones A., O'Loughlin V., Jarapa R., Naing Z., Lovelock C., O'Reilly J., Khan U., Bhalla A., Rudd A., Birns J., Werring D.J., Law R., Perry R., Jones I., Erande R., Roffe C., Natarajan I., Ahmad N., Finney K., Lucas J., Mistri A., Eveson D., Marsh R., Haunton V., Fugate J.E., Lepore S.W., Zheng D., Sato S., Arima H., Heeley E., Delcourt C., Cao Y., Chalmers J., Anderson C.S., Davis S., Huang Y., Lavados P., Neal B., Parsons M.W., Lindley R., Morgenstern L., Robinson T., Stapf C., Tzourio C., Wang J.G., Chen S., Chen X.Y., Cui L., Liu Z., Lu C., Wang J., Wu S., Xu E., Yang Q., Zhang C., Zhang J., Beer R., Schmutzhard E., Redondo P., Kaste M., Soinne L., Tatlisumak T., Wartenberg K., Ricci S., Klijn K., Azevedo E., Chamorro A., Arnold M., Fischer U., Kaul S., Pandian J., Boyini H., Singh S., Rabinstein A.A., Estol C., Silva G., Olavarria V.V., Robinson T.G., Simes R.J., Bousser M.-G., Hankey G., Jamrozik K., Johnston S.C., Li S., Bailey K., Cheung T., Chintapatla S., Ducasse E., Erho T., Hata J., Holder B., Knight E., Leroux M., Sasse T., Odgers E., Walsh R., Wolfowicz Z., Chen G., Fuentes S., Peng B., Schneble H.-M., Wang M.-X., Billot L., Heritier S., Li Q., Woodward M., Abimbola S., Anderson S., Chan E., Cheng G., Chmielnik P., Leighton S., Liu J.-Y., Rasmussen B., Saxena A., Tripathy S., Armenis M., Baig M.A., Naidu B., Starzec G., Steley S., Moles A., Ruiz A., Zimmermann M., Marinho J., Alves S., Angelim R., Araujo J., Kawakami L., Bustos C., Gonzalez F., Munoz Venturelli P., Chen X., Jia R., Li N., Qu S., Shu Y., Song A., Sun J., Xiao J., Zhao Y., Huang Q., Vicaut E., Chamam A., Viaud M.-C., Dert C., Fiedler U., Jovis V., Kabla S., Marchand S., Pena A., Mallikarjuna K., Hasan N., Berge E., Sandset E.C., Forarsveen A.S., Richardson D., Kumar T., Lewin S., Poulter N., Field J., Anjum A., Wilson A., Perelmuter H., Agarie A.M., Barboza A.G., Recchia L.A., Miranda I.F., Rauek S.G., Duplessis R.J., Dewey H., Walker L., Petrolo S., Bladin C., Sturm J., Crimmins D., Griffiths D., Schutz A., Zenteno V., Miteff F., Spratt N., Kerr E., Levi C.R., Phan T.G., Ma H., Sanders L., Moran C., Wong K., Read S., Henderson R., Wong A., Hull R., Skinner G., Hand P., Yan B., Tu H., Campbell B., Blacker D.J., Wijeratne T., Pathirage M., Jasinararchchi M., Matkovic Z., Celestino S., Gruber F., Vosko M.R., Diabl E., Rathmaier S., Pfausler B., Helbok R., Fazekas F., Poltrum B., Zechner B., Trummer U., Rutgers M.P., Peeters A., Dusart A., Duray M.-C., Parmentier C., Ferrao-Santos S., Brouns R., De Raedt S., De Smedt A., Vanhooff R.-J., De Keyser J., Martins S.C.O., De Almeida A.G., Broudani R., Titton N.F., De Freitas G.R., Cardoso F.M., Giesel L.M., Lima N.A., Ferraz De Almeida A.C., Gomes R.B., Borges Dos Santos T.S., Veloso Soares E.M., Neto O.L.A., Silva G.S., Gomes D.L., De Carvalho F.A., Miranda M., Marques A., Zetola V.F., De Matia G., Lange M.C., Montes J., Reccius A., Soto A., Rivas R., Klapp C., Illanes S., Aguilera C., Castro A., Figueroa C., Benavides J., Salamanca P., Concha M.C., Pajarito J., Araya P., Guerra F., Li Y., Liu G., Wang B., Chong Y., He M., Wang L., Liu J., Zhang X., Lai C., Jiang H., Cui S., Tao Q., Zhang Y., Yao S., Xu M., Xiao H., Hu J., Tang J., Ji H., Jiang M., Yu F., Yang X., Guo X., Wang Y., Wu L., Gao Y., Sun D., Huang X., Liu L., Li P., Jiang Y., Li H., Lu H., Zhou J., Yuan C., Qi X., Qiu F., Qian H., Wang W., Sun W., Li F., Liu R., Peng Q., Ren Z., Fan C., Wang H., Wang T., Shi F., Duan C., Chen Z., Tan X., Zhao Z., Chen J., Han T., Zhang L., Hu Q., Hou Q., Zhao X., Zeng G., Ma L., Wang F., Guo Z., Fu Y., Song Y., Tai L., Liu X., Su X., Yang Y., Dong R., Xu Y., Tian S., Cheng S., Su L., Xie X., Xu T., Geng D., Yan X., Fan H., Zhao N., Wang S., Yang J., Yan M., Li L., Li Z., Xu X., Lian Y., Sun H., Liu D., Wang N., Tang Q., Han Z., Feng L., Cui Y., Tian J., Chang H., Sun X., Liu C., Wen Z., Lin Q., Sun L., Hu B., Zou M., Bao Q., Lin X., Zhao L., Tian X., Wang X., Li X., Hao L., Duan Y., Wang R., Wei Z., Ren S., Ren H., Dong Y., Cheng Y., Liu W., Han J., Zhang Z., Zhu J., Qian J., Sun Y., Liu K., Long F., Peng X., Zhang Q., Yuan Z., Wang C., Huang M., He P., You Y., Xia J., Zhou L., Hou Y., Qi Y., Mei L., Lu R., Ping L., Zhou S., Zhang S., Zou R., Guo J., Li M., Wei W., Curtze S., Saarela M., Strbian D., Scheperjans F., De Broucker T., Henry C., Cumurciuc R., Ibos-Auge N., Zeghoudi A.-C., Pico F., Dereeper O., Simian M.-C., Boisselier C., Mahfoud A., Timsit S., Merrien F.M., Guillon B., Sevin M., Herisson F., Magne C., Ameri A., Cret C., Stefanizzi S., Klapzcynski F., Denier C., Sarov-Riviere M., Reiner P., Mawet J., Herve D., Buffon F., Touze E., Domigo V., Lamy C., Calvet D., Pasquini M., Alamowitch S., Favrole P., Muresan I.-P., Crozier S., Rosso C., Pires C., Leger A., Deltour S., Cordonnier C., Henon H., Rossi C., Zuber M., Bruandet M., Tamazyan R., Join-Lambert C., Juettler E., Krause T., Maul S., Endres M., Jungehulsing G.J., Hennerici M., Griebe M., Sauer T., Knoll K., Huber R., Knauer K., Knauer C., Raubold S., Schneider H., Hentschel H., Lautenschlager C., Schimmel E., Dzialowski I., Foerch C., Lorenz M., Singer O., Meyer Dos Santos I.M.R., Hartmann A., Hamann A., Schacht A., Schrader B., Teichmann A., Wartenberg K.E., Mueller T.J., Jander S., Gliem M., Boettcher C., Rosenkranz M., Beck C., Otto D., Thomalla G., Cheng B., Wong K.S., Leung T.W., Soo Y.O.Y., Prabhakar S., Kesavarapu S.R., Gajjela P.K., Chenna R.R., Ummer K., Basheer M., Andipet A., Jagarlapudi M.K.M., Mohammed A.U.R., Pawar V.G., Eranki S.S.K., Singh Y., Akhtar N., Borah N.C., Ghose M., Choudhury N., Ichaporia N.R., Shendge J., Khese S., Pamidimukkala V., Inbamuthaiah P., Nuthakki S.R., Tagallamudi N.M.R., Gutti A.K., Khurana D., Kesavarapu P., Jogi V., Garg A., Samanta D., Sarma G.R.K., Nadig R., Mathew T., Anandan M.A., Caterbi E., Zini A., Cavazzuti M., Casoni F., Pentore R., Falzone F., Mazzoli T., Greco L.M., Menichetti C., Coppola F., Cenciarelli S., Gallinella E., Mattioni A., Condurso R., Sicilia I., Zampolini M., Corea F., Barbi M., Proietti C., Toni D., Pieroni A., Anzini A., Falcou A., Demichele M., Klijn C.J.M., Tveiten A., Thortveit E.T., Pettersen S., Holand N., Hitland B., Johnsen S.H., Eltoft A., Wasay M., Kamal A., Iqrar A., Ali L., and Begum D.

Abstract

Background: The kidney-brain interaction has been a topic of growing interest. Past studies of the effect of kidney function on intracerebral hemorrhage (ICH) outcomes have yielded inconsistent findings. Although the second, main phase of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2) suggests the effectiveness of early intensive blood pressure (BP) lowering in improving functional recovery after ICH, the balance of potential benefits and harms of this treatment in those with decreased kidney function remains uncertain. Study Design: Secondary analysis of INTERACT2, which randomly assigned patients with ICH with elevated systolic BP (SBP) to intensive (target SBP < 140 mm Hg) or contemporaneous guideline-based (target SBP < 180 mm Hg) BP management. Setting & Participants: 2,823 patients from 144 clinical hospitals in 21 countries. Predictors Admission estimated glomerular filtration rates (eGFRs) of patients were categorized into 3 groups based on the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) creatinine equation: normal or high, mildly decreased, and moderately to severely decreased (>90, 60-90, and <60 mL/min/1.73 m2, respectively). Outcome(s): The effect of admission eGFR on the primary outcome of death or major disability at 90 days (defined as modified Rankin Scale scores of 3-6) was analyzed using a multivariable logistic regression model. Potential effect modification of intensive BP lowering treatment by admission eGFR was assessed by interaction terms. Result(s): Of 2,623 included participants, 912 (35%) and 280 (11%) had mildly and moderately/severely decreased eGFRs, respectively. Patients with moderately/severely decreased eGFRs had the greatest risk for death or major disability at 90 days (adjusted OR, 1.82; 95% CI, 1.28-2.61). Effects of early intensive BP lowering were consistent across different eGFRs (P = 0.5 for homogeneity). Limitation(s): Generalizability issues arising from a clinical tri

Published
2016

50. Estimated GFR and the Effect of Intensive Blood Pressure Lowering After Acute Intracerebral Hemorrhage

Author

Zheng, Danni, primary, Sato, Shoichiro, additional, Arima, Hisatomi, additional, Heeley, Emma, additional, Delcourt, Candice, additional, Cao, Yongjun, additional, Chalmers, John, additional, Anderson, Craig S., additional, Anderson, C.S., additional, Chalmers, J., additional, Arima, H., additional, Davis, S., additional, Heeley, E., additional, Huang, Y., additional, Lavados, P., additional, Neal, B., additional, Parsons, M.W., additional, Lindley, R., additional, Morgenstern, L., additional, Robinson, T., additional, Stapf, C., additional, Tzourio, C., additional, Wang, J.G., additional, Chen, S., additional, Chen, X.Y., additional, Cui, L., additional, Liu, Z., additional, Lu, C., additional, Wang, J., additional, Wu, S., additional, Xu, E., additional, Yang, Q., additional, Zhang, C., additional, Zhang, J., additional, Beer, R., additional, Schmutzhard, E., additional, Redondo, P., additional, Kaste, M., additional, Soinne, L., additional, Tatlisumak, T., additional, Wartenberg, K., additional, Ricci, S., additional, Klijn, K., additional, Azevedo, E., additional, Chamorro, A., additional, Arnold, M., additional, Fischer, U., additional, Kaul, S., additional, Pandian, J., additional, Boyini, H., additional, Singh, S., additional, Rabinstein, A.A., additional, Estol, C., additional, Silva, G., additional, Olavarria, V.V., additional, Robinson, T.G., additional, Simes, R.J., additional, Bousser, M.-G., additional, Hankey, G., additional, Jamrozik, K., additional, Johnston, S.C., additional, Li, S., additional, Bailey, K., additional, Cheung, T., additional, Delcourt, C., additional, Chintapatla, S., additional, Ducasse, E., additional, Erho, T., additional, Hata, J., additional, Holder, B., additional, Knight, E., additional, Leroux, M., additional, Sassé, T., additional, Odgers, E., additional, Walsh, R., additional, Wolfowicz, Z., additional, Chen, G., additional, Fuentes, S., additional, Peng, B., additional, Schneble, H.-M., additional, Wang, M.-X., additional, Billot, L., additional, Heritier, S., additional, Li, Q., additional, Woodward, M., additional, Abimbola, S., additional, Anderson, S., additional, Chan, E., additional, Cheng, G., additional, Chmielnik, P., additional, Leighton, S., additional, Liu, J.-Y., additional, Rasmussen, B., additional, Saxena, A., additional, Tripathy, S., additional, Armenis, M., additional, Baig, M.A., additional, Naidu, B., additional, Starzec, G., additional, Steley, S., additional, Moles, A., additional, Ruiz, A., additional, Zimmermann, M., additional, Marinho, J., additional, Alves, S., additional, Angelim, R., additional, Araujo, J., additional, Kawakami, L., additional, Bustos, C., additional, Gonzalez, F., additional, Munoz Venturelli, P., additional, Chen, X., additional, Jia, R., additional, Li, N., additional, Qu, S., additional, Shu, Y., additional, Song, A., additional, Sun, J., additional, Xiao, J., additional, Zhao, Y., additional, Huang, Q., additional, Vicaut, E., additional, Chamam, A., additional, Viaud, M.-C., additional, Dert, C., additional, Fiedler, U., additional, Jovis, V., additional, Kabla, S., additional, Marchand, S., additional, Pena, A., additional, Rochaud, V., additional, Mallikarjuna, K., additional, Hasan, N., additional, Berge, E., additional, Sandset, E.C., additional, Forårsveen, A.S., additional, Richardson, D., additional, Kumar, T., additional, Lewin, S., additional, Poulter, N., additional, Field, J., additional, Anjum, A., additional, Wilson, A., additional, Perelmuter, H., additional, Agarie, A.M., additional, Barboza, A.G., additional, Recchia, L.A., additional, Miranda, I.F., additional, Rauek, S.G., additional, Duplessis, R.J., additional, Dewey, H., additional, Walker, L., additional, Petrolo, S., additional, Bladin, C., additional, Sturm, J., additional, Crimmins, D., additional, Griffiths, D., additional, Schutz, A., additional, Zenteno, V., additional, Miteff, F., additional, Spratt, N., additional, Kerr, E., additional, Levi, C.R., additional, Phan, T.G., additional, Ma, H., additional, Sanders, L., additional, Moran, C., additional, Wong, K., additional, Read, S., additional, Henderson, R., additional, Wong, A., additional, Hull, R., additional, Skinner, G., additional, Hand, P., additional, Yan, B., additional, Tu, H., additional, Campbell, B., additional, Blacker, D.J., additional, Wijeratne, T., additional, Pathirage, M., additional, Jasinararchchi, M., additional, Matkovic, Z., additional, Celestino, S., additional, Gruber, F., additional, Vosko, M.R., additional, Diabl, E., additional, Rathmaier, S., additional, Pfausler, B., additional, Helbok, R., additional, Fazekas, F., additional, Fischer, R., additional, Poltrum, B., additional, Zechner, B., additional, Trummer, U., additional, Rutgers, M.P., additional, Peeters, A., additional, Dusart, A., additional, Duray, M.-C., additional, Parmentier, C., additional, Ferrao-Santos, S., additional, Brouns, R., additional, De Raedt, S., additional, De Smedt, A., additional, VanHooff, R.-J., additional, De Keyser, J., additional, Martins, S.C.O., additional, de Almeida, A.G., additional, Broudani, R., additional, Titton, N.F., additional, de Freitas, G.R., additional, Cardoso, F.M., additional, Giesel, L.M., additional, Lima, N.A., additional, Ferraz de Almeida, A.C., additional, Gomes, R.B., additional, Borges dos Santos, T.S., additional, Veloso Soares, E.M., additional, Neto, O.L.A., additional, Silva, G.S., additional, Gomes, D.L., additional, de Carvalho, F.A., additional, Miranda, M., additional, Marques, A., additional, Zétola, V.F., additional, de Matia, G., additional, Lange, M.C., additional, Montes, J., additional, Reccius, A., additional, Soto, A., additional, Rivas, R., additional, Klapp, C., additional, Illanes, S., additional, Aguilera, C., additional, Castro, A., additional, Figueroa, C., additional, Benavides, J., additional, Salamanca, P., additional, Concha, M.C., additional, Pajarito, J., additional, Araya, P., 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Pettersen, S., additional, Holand, N., additional, Hitland, B., additional, Johnsen, S.H., additional, Eltoft, A., additional, Wasay, M., additional, Kamal, A., additional, Iqrar, A., additional, Ali, L., additional, Begum, D., additional, Gama, G., additional, Fonseca, L., additional, Moreira, G., additional, Veloso, L.M., additional, Pinheiro, D., additional, Paredes, L., additional, Rozeira, C., additional, Gregorio, T., additional, Segura Martin, T., additional, Ayo, O., additional, Garcia-Garcia, J., additional, Feria Vilar, I., additional, Gómez Fernández, I., additional, Amaro, S., additional, Urra, X., additional, Obach, V., additional, Cervera, A., additional, Silva, Y., additional, Serena, J., additional, Castellanos, M., additional, Terceno, M., additional, Van Eendenburg, C., additional, Weck, A., additional, Findling, O., additional, Lüdi, R., additional, Warburton, E.A., additional, Day, D., additional, Butler, N., additional, Bumanlag, E., additional, Caine, S., 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additional, Kwan, J., additional, David, O., additional, Tiwari, D., additional, James, M., additional, Keenan, S., additional, Eastwood, H., additional, Shaw, L., additional, Kaye, P., additional, Button, D., additional, Madigan, B., additional, Williamson, D., additional, Dixit, A., additional, Davis, J., additional, Hossain, M.O., additional, Ford, G.A., additional, Parry-Jones, A., additional, O'Loughlin, V., additional, Jarapa, R., additional, Naing, Z., additional, Lovelock, C., additional, O'Reilly, J., additional, Khan, U., additional, Bhalla, A., additional, Rudd, A., additional, Birns, J., additional, Werring, D.J., additional, Law, R., additional, Perry, R., additional, Jones, I., additional, Erande, R., additional, Roffe, C., additional, Natarajan, I., additional, Ahmad, N., additional, Finney, K., additional, Lucas, J., additional, Mistri, A., additional, Eveson, D., additional, Marsh, R., additional, Haunton, V., additional, Fugate, J.E., additional, and Lepore, S.W., additional

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2016
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