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1. Protein intake and cancer: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society

Author

Kühn, Tilman, Kalotai, Nicole, Amini, Anna M., Haardt, Julia, Lehmann, Andreas, Schmidt, Annemarie, Buyken, Anette E., Egert, Sarah, Ellinger, Sabine, Kroke, Anja, Lorkowski, Stefan, Louis, Sandrine, Schulze, Matthias B., Schwingshackl, Lukas, Siener, Roswitha, Stangl, Gabriele I., Watzl, Bernhard, Zittermann, Armin, and Nimptsch, Katharina

Published
2024
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5. Dietary protein and blood pressure: an umbrella review of systematic reviews and evaluation of the evidence

Author

Boeing, Heiner, Amini, Anna M., Haardt, Julia, Schmidt, Annemarie, Bischoff-Ferrari, Heike A., Buyken, Anette E., Egert, Sarah, Ellinger, Sabine, Kroke, Anja, Lorkowski, Stefan, Louis, Sandrine, Nimptsch, Katharina, Schulze, Matthias B., Schutkowski, Alexandra, Schwingshackl, Lukas, Siener, Roswitha, Zittermann, Armin, Watzl, Bernhard, and Stangl, Gabriele I.

Published
2024
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6. Protein intake and body weight, fat mass and waist circumference: an umbrella review of systematic reviews for the evidence-based guideline on protein intake of the German Nutrition Society

Author

Ellinger, Sabine, Amini, Anna M., Haardt, Julia, Lehmann, Andreas, Schmidt, Annemarie, Bischoff-Ferrari, Heike A., Buyken, Anette E., Kroke, Anja, Kühn, Tilman, Louis, Sandrine, Lorkowski, Stefan, Nimptsch, Katharina, Schulze, Matthias B., Schwingshackl, Lukas, Siener, Roswitha, Stangl, Gabriele I., Volkert, Dorothee, Zittermann, Armin, Watzl, Bernhard, and Egert, Sarah

Published
2024
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7. Protein intake and type 2 diabetes mellitus: an umbrella review of systematic reviews for the evidence-based guideline for protein intake of the German Nutrition Society

Author

Schulze, Matthias B., Haardt, Julia, Amini, Anna M., Kalotai, Nicole, Lehmann, Andreas, Schmidt, Annemarie, Buyken, Anette E., Egert, Sarah, Ellinger, Sabine, Kroke, Anja, Kühn, Tilman, Louis, Sandrine, Nimptsch, Katharina, Schwingshackl, Lukas, Siener, Roswitha, Zittermann, Armin, Watzl, Bernhard, and Lorkowski, Stefan

Published
2024
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8. Association of dietary patterns with diabetes-related comorbidities varies among diabetes endotypes

Author

Roden, M., Al-Hasani, H., Belgardt, B., Lammert, E., Bönhof, G., Geerling, G., Herder, C., Icks, A., Jandeleit-Dahm, K., Kotzka, J., Kuß, O., Rathmann, W., Schlesinger, S., Schrauwen-Hinderling, V., Szendroedi, J., Trenkamp, S., Wagner, R., Weber, Katharina S., Schlesinger, Sabrina, Lang, Alexander, Straßburger, Klaus, Maalmi, Haifa, Zhu, Anna, Zaharia, Oana-Patricia, Strom, Alexander, Bönhof, Gidon J., Goletzke, Janina, Trenkamp, Sandra, Wagner, Robert, Buyken, Anette E., Lieb, Wolfgang, Roden, Michael, and Herder, Christian

Published
2024
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12. Relative validity of a glycemic index extended food-frequency questionnaire

Author

M.Roden, Al-Hasani, H., Belgardt, B., Burkart, V., Buyken, A.E., Geerling, G., Herder, C., Icks, A., Jandeleit-Dahm, K., Kahl, S., Kotzka, J., Kuß, O., Lammert, E., Rathmann, W., Schrauwen-Hinderling, V., Szendroedi, J., Trenkamp, S., Ziegler, D., Goletzke, Janina, Weber, Katharina S., Kössler, Theresa, Zaharia, Oana-Patricia, Bódis, Kálmán, Müssig, Karsten, Szendroedi, Julia, Burkart, Volker, Stutz, Bianca, Nöthlings, Ute, Buyken, Anette E., and Roden, Michael

Published
2022
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13. Associations of carbohydrate quality and cardiovascular risk factors vary among diabetes subtypes.

Author

Weber, Katharina S., Schlesinger, Sabrina, Goletzke, Janina, Straßburger, Klaus, Zaharia, Oana-Patricia, Trenkamp, Sandra, Wagner, Robert, Lieb, Wolfgang, Buyken, Anette E., Roden, Michael, Herder, Christian, Roden, M., Al-Hasani, H., Belgardt, B., Bönhof, G., Geerling, G., Guthoff, R., Herder, C., Icks, A., and Jandeleit-Dahm, K.

Subjects
CARDIOVASCULAR diseases risk factors, GLYCEMIC index, BLOOD lipids, DIETARY carbohydrates, FATTY liver
Abstract

Background: Assess the intake of carbohydrate quality and their association with cardiovascular risk factors among diabetes subtypes. Methods: Participants of the German Diabetes Study (GDS) (recent-onset diabetes (n = 487) and 5-years thereafter (n = 209)) were allocated into severe autoimmune diabetes (SAID, 35%), severe insulin-deficient diabetes (SIDD, 3%), severe insulin-resistant diabetes (SIRD, 5%), mild obesity-related diabetes (MOD, 28%), and mild age-related diabetes (MARD, 29%). Dietary glycemic index (GI), glycemic load (GL), and intake of higher- (≥ 55) and low-GI (< 55) foods, dietary fiber, and total sugar were derived from a validated food frequency questionnaire and cross-sectionally associated with cardiovascular risk factors (blood lipids, subclinical inflammation, blood pressure, fatty liver index) using multivariable linear regression analysis for subtypes with prevalences ≥ 10%. Results: Intake of carbohydrate quality parameters was broadly comparable between the subtypes. Among SAID higher total sugar intake was associated with lower HDL-cholesterol (ß (95% CI) relative change per 1 SD increment: − 3.4% (− 6.7; − 0.1)). No clear associations were seen among MOD. Among MARD, a higher dietary GL and higher-GI carbohydrate intake were associated with higher serum triglycerides (10.9% (2.4; 20.1), 12.4% (3.9; 21.5)) and fatty liver index (absolute change: 0.18 (0.06; 0.31), 0.17 (0.05; 0.28)) and lower HDL-cholesterol (− 4.1% (− 7.6; − 0.4), − 4.4% (− 7.8; − 0.8)), whilst higher intake of low-GI carbohydrates and dietary fiber were associated with lower high-sensitivity C-reactive protein (− 16.0% (− 25.7; − 5.1), − 13.9% (− 24.2; − 2.2)). Conclusions: Associations of carbohydrate quality parameters with blood lipids, subclinical inflammation, and fatty liver index differed between diabetes subtypes. However, evidence is too preliminary to derive subtype-specific recommendations. Trial registration: Clinicaltrials.gov: NCT01055093. [ABSTRACT FROM AUTHOR]

Published
2025
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15. Dietary protein intake and health-related outcomes: a methodological protocol for the evidence evaluation and the outline of an evidence to decision framework underlying the evidence-based guideline of the German Nutrition Society

Author

Kroke, Anja, Schmidt, Annemarie, Amini, Anna M., Kalotai, Nicole, Lehmann, Andreas, Haardt, Julia, Bauer, Jürgen M., Bischoff-Ferrari, Heike A., Boeing, Heiner, Egert, Sarah, Ellinger, Sabine, Kühn, Tilman, Louis, Sandrine, Lorkowski, Stefan, Nimptsch, Katharina, Remer, Thomas, Schulze, Matthias B., Siener, Roswitha, Stangl, Gabriele I., Volkert, Dorothee, Zittermann, Armin, Buyken, Anette E., Watzl, Bernhard, and Schwingshackl, Lukas

Published
2022
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21. Relevance of high glycaemic index breakfast for heart rate variability among collegiate students with early and late chronotypes.

Author

Krueger, Bettina, Stutz, Bianca, Jakobsmeyer, Rasmus, Reinsberger, Claus, and Buyken, Anette E.

Subjects
HEART beat, GLYCEMIC index, BLOOD sugar, BLOOD volume, CHRONOTYPE
Abstract

Plasma glucose spikes affect cardiac autonomic modulation resulting in a decrease of heart rate variability (HRV). We hypothesize that a later chronotype or a higher morning plasma melatonin level is associated with larger decreases of HRV following an early high glycaemic index (GI) breakfast. In persons with an early (n = 21) or a late (n = 15) chronotype who consumed a high GI breakfast at 7 a.m. glucose data were continuously monitored. Time domain HRV parameters were calculated from blood volume pulses derived by wireless wrist worn multisensor. HRV changes (values after minus values before breakfast) were associated with chronotype by multivariable linear regression adjusted for age, sex and baseline levels. Morning plasma melatonin levels were determined from samples drawn on the run-in day. Time domain parameters indicate a higher HRV before high GI breakfast in both chronotypes. A later chronotype tended to be associated with smaller decreases of mean interbeat intervals (p = 0.08) only; no associations were seen with morning melatonin levels. This exploratory analysis in a small sample provides a first indication that in young healthy adults later chronotype might be associated with reduced ANS activation following a high GI breakfast. Future studies should elucidate whether this indicates parasympathetic or sympathetic inhibition. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Adherence to the Dietary Approaches to Stop Hypertension (DASH) diet is associated with lower visceral and hepatic lipid content in recent‐onset type 1 diabetes and type 2 diabetes.

Author

Schaefer, Edyta, Lang, Alexander, Kupriyanova, Yuliya, Bódis, Kálmán B., Weber, Katharina S., Buyken, Anette E., Barbaresko, Janett, Kössler, Theresa, Kahl, Sabine, Zaharia, Oana‐Patricia, Szendroedi, Julia, Herder, Christian, Schrauwen‐Hinderling, Vera B., Wagner, Robert, Kuss, Oliver, Roden, Michael, and Schlesinger, Sabrina

Subjects
DASH diet, TYPE 2 diabetes, TYPE 1 diabetes, PEOPLE with diabetes, BODY mass index, ADIPOSE tissues
Abstract

Aim: To investigate the associations of the Dietary Approaches to Stop Hypertension (DASH) score with subcutaneous (SAT) and visceral (VAT) adipose tissue volume and hepatic lipid content (HLC) in people with diabetes and to examine whether changes in the DASH diet were associated with changes in these outcomes. Methods: In total, 335 participants with recent‐onset type 1 diabetes (T1D) and type 2 diabetes (T2D) from the German Diabetes Study were included in the cross‐sectional analysis, and 111 participants in the analysis of changes during the 5‐year follow‐up. Associations between the DASH score and VAT, SAT and HLC and their changes were investigated using multivariable linear regression models by diabetes type. The proportion mediated by changes in potential mediators was determined using mediation analysis. Results: A higher baseline DASH score was associated with lower HLC, especially in people with T2D (per 5 points: −1.5% [−2.7%; −0.3%]). Over 5 years, a 5‐point increase in the DASH score was associated with decreased VAT in people with T2D (−514 [−800; −228] cm3). Similar, but imprecise, associations were observed for VAT changes in people with T1D (−403 [−861; 55] cm3) and for HLC in people with T2D (−1.3% [−2.8%; 0.3%]). Body mass index and waist circumference changes explained 8%‐48% of the associations between DASH and VAT changes in both groups. In people with T2D, adipose tissue insulin resistance index (Adipo‐IR) changes explained 47% of the association between DASH and HLC changes. Conclusions: A shift to a DASH‐like diet was associated with favourable VAT and HLC changes, which were partly explained by changes in anthropometric measures and Adipo‐IR. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Association of dietary patterns with diabetes-related comorbidities varies among diabetes endotypes

Author

Weber, Katharina S., primary, Schlesinger, Sabrina, additional, Lang, Alexander, additional, Straßburger, Klaus, additional, Maalmi, Haifa, additional, Zhu, Anna, additional, Zaharia, Oana-Patricia, additional, Strom, Alexander, additional, Bönhof, Gidon J., additional, Goletzke, Janina, additional, Trenkamp, Sandra, additional, Wagner, Robert, additional, Buyken, Anette E., additional, Lieb, Wolfgang, additional, Roden, Michael, additional, Herder, Christian, additional, Roden, M., additional, Al-Hasani, H., additional, Belgardt, B., additional, Lammert, E., additional, Bönhof, G., additional, Geerling, G., additional, Herder, C., additional, Icks, A., additional, Jandeleit-Dahm, K., additional, Kotzka, J., additional, Kuß, O., additional, Rathmann, W., additional, Schlesinger, S., additional, Schrauwen-Hinderling, V., additional, Szendroedi, J., additional, Trenkamp, S., additional, and Wagner, R., additional

Published
2024
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25. Short-term effects of carbohydrates differing in glycemic index (GI) consumed at lunch on children's cognitive function in a randomized crossover study

Author

Jansen, Kathrin, Tempes, Jana, Drozdowska, Alina, Gutmann, Maike, Falkenstein, Michael, Buyken, Anette E., and Libuda, Lars

Subjects
Rankings, Analysis, Diet therapy, Cognition -- Analysis, Batteries -- Rankings, Glycemic index -- Analysis, Children -- Analysis, Elementary school students -- Analysis
Abstract

Author(s): Kathrin Jansen [sup.1], Jana Tempes [sup.2], Alina Drozdowska [sup.1], Maike Gutmann [sup.1] [sup.3], Michael Falkenstein [sup.4], Anette E. Buyken [sup.5], Lars Libuda [sup.6], Henrik Rudolf [sup.7], Thomas Lücke [sup.1], [...], Background Intervention studies suggest an influence of breakfast dietary glycemic index (GI) on children's cognition. The Cognition Intervention Study Dortmund-GI-I study examined whether lunch dietary GI might have short-term effects on selected cognitive parameters. Methods A randomized crossover study was performed at a comprehensive school on 2 test days. One hundred and eighty-nine participants (5th and 6th grade) were randomly assigned to one of the two sequences, medium-high GI (m-hGI) or high-medium GI (h-mGI), following block randomization. In the first period, one group received a dish containing hGI rice (GI: 86) ad libitum, the other mGI rice (GI: 62)--1 week later, in the second period, vice versa. Tonic alertness, task switching, and working memory updating were tested with a computerized test battery 45 min after beginning of lunch break. Treatment effects were estimated using the t test for normally distributed data or the Wilcoxon rank-sum test for non-normally distributed data. Results The crossover approach revealed no effects of lunch dietary GI on the tested cognitive parameters in the early afternoon. However, we determined carryover effects for two parameters, and therefore analyzed only data of the first period. The reaction time of the two-back task (working memory updating) was faster (p = 0.001) and the count of commission errors in the alertness task was lower (p = 0.04) in the hGI group. Conclusion No evidence of short-term effects of lunch dietary GI on cognition of schoolchildren was found. Potential positive effects on single parameters of working memory updating and tonic alertness favoring hGI rice need to be verified.

Published
2020
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32. Perspective: A Conceptual Framework for Adaptive Personalized Nutrition Advice Systems

Author

Renner, Britta, primary, Buyken, Anette E., additional, Gedrich, Kurt, additional, Lorkowski, Stefan, additional, Watzl, Bernhard, additional, Linseisen, Jakob, additional, Daniel, Hannelore, additional, Conrad, Johanna, additional, Ferrario, Paola G., additional, Holzapfel, Christina, additional, Leitzmann, Michael, additional, Richter, Margrit, additional, Simon, Marie-Christine, additional, Sina, Christian, additional, and Wirsam, Jan, additional

Published
2023
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35. Plant-based dietary patterns and cardiometabolic risk factors in subgroups of individuals with diabetes

Author

Weber, Katharina S., additional, Schlesinger, Sabrina, additional, Lang, Alexander, additional, Straßburger, Klaus, additional, Maalmi, Haifa, additional, Zaharia, Oana P., additional, Goletzke, Janina, additional, Buyken, Anette E., additional, Trenkamp, Sandra, additional, Wagner, Robert, additional, Lieb, Wolfgang, additional, Roden, Michael, additional, and Herder, Christian, additional

Published
2023
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40. Perspective: a conceptual framework for adaptive personalized nutrition advice systems (APNASs)

Author

Renner, Britta, Buyken, Anette E., Gedrich, Kurt, Lorkowski, Stefan, Watzl, Bernhard, Linseisen, Jakob, Daniel, Hannelore, Conrad, Johanna, Ferrario, Paola G., Holzapfel, Christina, Leitzmann, Michael, Richter, Margrit, Simon, Marie-Christine, Sina, Christian, and Wirsam, Jan

Subjects
ddc:610
Abstract

Nearly all approaches to personalized nutrition (PN) use information such as the gene variants of individuals to deliver advice that is more beneficial than a generic one-size-fits-all recommendation. Despite great enthusiasm and the increased availability of commercial services, thus far, scientific studies have only revealed small to negligible effects on the efficacy and effectiveness of personalized dietary recommendations, even when using genetic or other individual information. In addition, from a public health perspective, scholars are critical of PN because it primarily targets socially privileged groups rather than the general population, thereby potentially widening health inequality. Therefore, in this perspective, we propose to extend current PN approaches by creating adaptive personalized nutrition advice systems (APNASs) that are tailored to the type and timing of personalized advice for individual needs, capacities, and receptivity in real-life food environments. These systems encompass a broadening of current PN goals (i.e., what should be achieved) to incorporate individual goal preferences beyond currently advocated biomedical targets (e.g., making sustainable food choices). Moreover, they cover the personalization processes of behavior change by providing in situ, just-in-time information in real-life environments (how and when to change), which accounts for individual capacities and constraints (e.g., economic resources). Finally, they are concerned with a participatory dialogue between individuals and experts (e.g., actual or virtual dieticians, nutritionists, and advisors), when setting goals and deriving measures of adaption. Within this framework, emerging digital nutrition ecosystems enable continuous, real-time monitoring, advice, and support in food environments from exposure to consumption. We present this vision of a novel PN framework along with scenarios and arguments that describe its potential to efficiently address individual and population needs and target groups that would benefit most from its implementation.

Published
2023

41. A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Author

Schadow, Alena M, Revheim, Ingrid, Spielau, Ulrike, Dierkes, Jutta, Schwingshackl, Lukas, Frank, Jan, Hodgson, Jonathan M, Moreira-Rosário, André, Seal, Chris J, Buyken, Anette E, Rosendahl-Riise, Hanne, Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS), and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Adult, Glycated Hemoglobin, Dietary Fiber, Diabetes Mellitus, Type 2, SDG 3 - Good Health and Well-being, Cardiovascular Diseases, Humans, Insulin, Bread, Blood Glucose/analysis, Randomized Controlled Trials as Topic
Abstract

Copyright © 2022. Published by Elsevier Inc. Bread is a major source of grain-derived carbohydrates worldwide. High intakes of refined grains, low in dietary fiber and high in glycemic index, are linked with increased risk for type 2 diabetes mellitus (T2DM) and other chronic diseases. Hence, improvements in the composition of bread could influence population health. This systematic review evaluated the effect of regular consumption of reformulated breads on glycemic control among healthy adults, adults at cardiometabolic risk or with manifest T2DM. A literature search was performed using MEDLINE, Embase, Web of Science and the Cochrane Central Register of Controlled Trials. Eligible studies employed a bread intervention (≥2 wk) in adults (healthy, at cardiometabolic risk or manifest T2DM) and reported glycemic outcomes (fasting blood glucose, fasting insulin, HOMA-IR, HbA1c, and postprandial glucose responses). Data were pooled using generic inverse variance with random-effects model and presented as mean difference (MD) or standardized MD between treatments with 95% CIs. Twenty-two studies met the inclusion criteria (n = 1037 participants). Compared with "regular" or comparator bread, consumption of reformulated intervention breads yielded lower fasting blood glucose concentrations (MD: -0.21 mmol/L; 95% CI: -0.38, -0.03; I2 = 88%, moderate certainty of evidence), yet no differences in fasting insulin (MD: -1.59 pmol/L; 95% CI: -5.78, 2.59; I2 = 38%, moderate certainty of evidence), HOMA-IR (MD: -0.09; 95% CI: -0.35, 0.23; I2 = 60%, moderate certainty of evidence), HbA1c (MD: -0.14; 95% CI: -0.39, 0.10; I2 = 56%, very low certainty of evidence), or postprandial glucose response (SMD: -0.46; 95% CI: -1.28, 0.36; I2 = 74%, low certainty of evidence). Subgroup analyses revealed a beneficial effect for fasting blood glucose only among people with T2DM (low certainty of evidence). Our findings suggest a beneficial effect of reformulated breads high in dietary fiber, whole grains, and/or functional ingredients on fasting blood glucose concentrations in adults, primarily among those with T2DM. This trial was registered at PROSPERO as CRD42020205458. publishersversion published

Published
2023

47. Metabolic flexibility and oxidative capacity independently associate with insulin sensitivity in individuals with newly diagnosed type 2 diabetes

Author

Apostolopoulou, Maria, Strassburger, Klaus, Herder, Christian, Knebel, Birgit, Kotzka, Jörg, Szendroedi, Julia, Roden, Michael, Roden, M., Buyken, A. E., Eckel, J., Geerling, G., Al-Hasani, H., Herder, C., Icks, A., Kotzka, J., Kuss, O., Lammert, E., Lundbom, J., Müssig, K., Nowotny, P., Rathmann, W., Szendroedi, J., Ziegler, D., and for the GDS group

Published
2016
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