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2. The Oncoprotein Fra-2 Drives the Activation of Human Endogenous Retrovirus Env Expression in Adult T-Cell Leukemia/Lymphoma (ATLL) Patients.

Author

Tram, Julie, Marty, Laetitia, Mourouvin, Célima, Abrantes, Magali, Jaafari, Ilham, Césaire, Raymond, Hélias, Philippe, Barbeau, Benoit, Mesnard, Jean-Michel, Baccini, Véronique, Chaloin, Laurent, and Peloponese, Jean-Marie Jr.

Subjects
ADULT T-cell leukemia, HTLV-I, HUMAN endogenous retroviruses, RETROVIRUS diseases, ENDOGENOUS retroviruses
Abstract

Human endogenous retroviruses (HERVs) are retroviral sequences integrated into 8% of the human genome resulting from ancient exogenous retroviral infections. Unlike endogenous retroviruses of other mammalian species, HERVs are mostly replication and retro-transposition defective, and their transcription is strictly regulated by epigenetic mechanisms in normal cells. A significant addition to the growing body of research reveals that HERVs' aberrant activation is often associated with offsetting diseases like autoimmunity, neurodegenerative diseases, cancers, and chemoresistance. Adult T-cell leukemia/lymphoma (ATLL) is a very aggressive and chemoresistant leukemia caused by the human T-cell leukemia virus type 1 (HTLV-1). The prognosis of ATLL remains poor despite several new agents being approved in the last few years. In the present study, we compare the expression of HERV genes in CD8+-depleted PBMCs from HTLV-1 asymptomatic carriers and patients with acute ATLL. Herein, we show that HERVs are highly upregulated in acute ATLL. Our results further demonstrate that the oncoprotein Fra-2 binds the LTR region and activates the transcription of several HERV families, including HERV-H and HERV-K families. This raises the exciting possibility that upregulated HERV expression could be a key factor in ATLL development and the observed chemoresistance, potentially leading to new therapeutic strategies and significantly impacting the field of oncology and virology. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Molecular epidemiology identifies the expansion of the DENV2 epidemic lineage from the French Caribbean Islands to French Guiana and mainland France, 2023 to 2024.

Author

Klitting, Raphaëlle, Piorkowski, Géraldine, Rousset, Dominique, Cabié, André, Frumence, Etienne, Lagrave, Alisé, Lavergne, Anne, Enfissi, Antoine, Dos Santos, George, Fagour, Laurence, Césaire, Raymond, Jaffar-Bandjee, Marie-Christine, Traversier, Nicolas, Gérardin, Patrick, Amaral, Rayane, Fournier, Lucie, Leon, Lucie, Dorléans, Frédérique, Vincent, Muriel, and Fontaine, Albin

Published
2024
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4. Phylogenetic Investigations of Dengue 2019–2021 Outbreak in Guadeloupe and Martinique Caribbean Islands

Author

Garcia--Van Smévoorde, Margot, primary, Piorkowski, Géraldine, additional, Emboulé, Loic, additional, Dos Santos, Georges, additional, Loraux, Cécile, additional, Guyomard-Rabenirina, Stéphanie, additional, Joannes, Marie-Odile, additional, Fagour, Laurence, additional, Najioullah, Fatiha, additional, Cabié, André, additional, de Lamballerie, Xavier, additional, Vega-Rúa, Anubis, additional, Césaire, Raymond, additional, and Calvez, Elodie, additional

Published
2023
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6. Guillain-Barré Syndrome Associated With Zika Virus Infection in Martinique in 2016 : A Prospective Study

Author

Guillain-Barré Syndrome Zika Working Group of Martinique, Rozé, Benoît, Najioullah, Fatiha, Fergé, Jean-Louis, Dorléans, Frédérique, Apetse, Kossivi, Barnay, Jose-Luis, Daudens-Vaysse, Elise, Brouste, Yannick, Césaire, Raymond, Fagour, Laurence, Valentino, Ruddy, Ledrans, Martine, Mehdaoui, Hossein, Abel, Sylvie, Leparc-Goffart, Isabelle, Signate, Aissatou, and Cabié, André

Published
2017

8. Long-term outcome in neuroZika: When biological diagnosis matters

Author

Lannuzel, Annie, Fergé, Jean-Louis, Lobjois, Quentin, Signate, Aissatou, Rozé, Benoit, Tressières, Benoit, Madec, Yoann, Poullain, Pascale, Herrmann, Cécile, Najioullah, Fatiha, McGovern, Eavan, Savidan, Anne-Charlotte, Valentino, Ruddy, Breurec, Sébastien, Césaire, Raymond, Hirsch, Etienne, Lledo, Pierre-Marie, Thiery, Guillaume, Cabié, André, Lazarini, Françoise, and Roze, Emmanuel

Published
2019
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10. Fundus Changes in the Offspring of Mothers With Confirmed Zika Virus Infection During Pregnancy in French Guiana, Guadeloupe, and Martinique, French West Indies

Author

Merle, Harold, primary, Chassery, Maxime, additional, Béral, Laurence, additional, Najioullah, Fatiha, additional, Cabié, André, additional, Césaire, Raymond, additional, Fléchelles, Olivier, additional, Pignol, Jérome, additional, Errera, Marie-Hélène, additional, Ventura, Eric, additional, Grant, Rebecca, additional, Fontanet, Arnaud, additional, David, Thierry, additional, Tressières, Benoit, additional, and Hoen, Bruno, additional

Published
2022
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12. Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas

Author

Hoen, Bruno, Schaub, Bruno, Funk, Anna L., Ardillon, Vanessa, Boullard, Manon, Cabié, André, Callier, Caroline, Carles, Gabriel, Cassadou, Sylvie, Césaire, Raymond, Douine, Maylis, Herrmann-Storck, Cécile, Kadhel, Philippe, Laouénan, Cédric, Madec, Yoann, Monthieux, Alice, Nacher, Mathieu, Najioullah, Fatiha, Rousset, Dominique, Ryan, Catherine, Schepers, Kinda, Stegmann-Planchard, Sofia, Tressières, Benoît, Voluménie, Jean-Luc, Yassinguezo, Samson, Janky, Eustase, and Fontanet, Arnaud

Published
2018
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17. Early assessment of diffusion and possible expansion of SARS-CoV-2 Lineage 20I/501Y.V1 (B.1.1.7, variant of concern 202012/01) in France, January to March 2021

Author

Gaymard, Alexandre, Bosetti, Paolo, Feri, Adeline, Destras, Gregory, Enouf, Vincent, Andronico, Alessio, Burrel, Sonia, Behillil, Sylvie, Sauvage, Claire, Bal, Antonin, Morfin, Florence, Van Der Werf, Sylvie, Josset, Laurence, Blanquart, François, Coignard, Bruno, Cauchemez, Simon, Lina, Bruno, Gault, Elyanne, Moreau, Frédérique, Brichler, Ségolène, Delagrèverie, Héloïse, Descamps, Diane, Charpentier, Charlotte, Rozenberg, Flore, L'Honneur, Anne-Sophie, Veyer, David, Bélec, Laurent, Fourati, Slim, Rodriguez, Christophe, Pawlotsky, Jean-Michel, Fourgeaud, Jacques, Abid, Hanène, Roque-Afonso, Anne-Marie, Fenaux, Honorine, Jary, Aude, Marot, Stéphane, Salmona, Maud, Chaix, Marie-Laure, Morand-Joubert, Laurence, Schnuriger, Aurélie, Juillet, Stéphanie Marque, Bargain, Pauline, Poggi, Cécile, Chollet, Lionel, Guillaume, Clémence, Guinard, Jérôme, Vallet, Sophie, Pilorgé, Léa, Schvoerer, Evelyne, Hartard, Cédric, Castelain, Sandrine, François, Catherine, Ducancelle, Alexandra, Lefeuvre, Caroline, Lepiller, Quentin, Marty-Quinternet, Solène, Bellecave, Pantxika, Tumiotto, Camille, Dina, Julia, Le Gouil, Meriadeg, Henquell, Cécile, Mirand, Audrey, Césaire, Raymond, de Rougemont, Alexis, Auvray, Christelle, Larrat, Sylvie, Némoz, Benjamin, Tinez, Claire, Guigon, Aurélie, Hantz, Sébastien, Rogez, Sylvie, Dos Santos, Georges, Perez, Pascale, Jost, Christelle, Montes, Brigitte, Foulongne, Vincent, Imbert, Berthe-Marie, Bressollette, Céline, Giordanengo, Valérie, Gonfrier, Géraldine, Garcia, Magali, Lévêque, Nicolas, Brodard, Véronique, Moret, Hélène, Thibault, Vincent, Maillard, Anne, Jaffar-Bandjee, Marie-Christine, Gueudin, Marie, Plantier, Jean-Christophe, Pozzetto, Bruno, Pillet, Sylvie, Fafi-Kremer, Samira, Solis, Morgane, Izopet, Jacques, Trémeaux, Pauline, Stefic, Karl, Handala, Lynda, Billaud, Geneviève, Frobert, Emilie, Mérens, Audrey, Bigaillon, Christine, Desroches, Marine, Thepenier, Cédric, Janvier, Frédéric, Otto, Marie-Pierre, Roquebert, Bénédicte, Haïm-Boukobza, Stéphanie, Centre National de Référence des Virus des Infections Respiratoires (dont la Grippe) [Lyon] (CNR - laboratoire associé), Institut des Agents Infectieux [Lyon] (IAI), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Hospices Civils de Lyon (HCL), Virpath-Grippe, de l'émergence au contrôle -- Virpath-Influenza, from emergence to control (Virpath), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Direction des maladies infectieuses - Infectious Diseases Division [Saint-Maurice], Santé publique France - French National Public Health Agency [Saint-Maurice, France], Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur), Institut Pasteur [Paris] (IP), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Laboratoire de Virologie [CHU Amiens], CHU Amiens-Picardie, ANRS - Maladies infectieuses émergentes (ANRS - MIE), Institut National de la Santé et de la Recherche Médicale (INSERM), We acknowledge financial support from Santé publique France (the French national public health agency), the French Ministry of health (Grant COVIDseq), the Consortium for the surveillance and research on emerging pathogens via microbial genomics (EMERGEN) coordinated by Santé publique France and ANRS Maladies Infectieuses Emergentes, the Investissement d’Avenir programme, the Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases programme (grant ANR-10-LABX-62-IBEID), the European Union’s Horizon 2020 research and in-novation programme under grants 101003589 (RECOVER). This work has been supported by the laboratories belonging to the ColVHB network*., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), European Project: 101003589, H2020-SC1-PHE-CORONAVIRUS-2020,RECOVER(2020), Centre National de Référence des Virus des Infections Respiratoires (dont la Grippe) [Lyon] (CNR), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR), Institut Pasteur [Paris], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Gestionnaire, Hal Sorbonne Université, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID, Rapid European COVID-19 Emergency Response research - RECOVER - - H2020-SC1-PHE-CORONAVIRUS-20202020-02-14 - 2022-02-13 - 101003589 - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris)

Subjects
Author's Correction, Paris, medicine.medical_specialty, 2019-20 coronavirus outbreak, Lineage (genetic), Coronavirus disease 2019 (COVID-19), Epidemiology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), viral infections, [SDV]Life Sciences [q-bio], Context (language use), Biology, 03 medical and health sciences, 0302 clinical medicine, Virology, medicine, Humans, MESH: COVID-19, MESH: SARS-CoV-2, 030212 general & internal medicine, 030304 developmental biology, COVID, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, 0303 health sciences, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, MESH: Humans, SARS-CoV-2, MESH: Paris, Public Health, Environmental and Occupational Health, COVID-19, [SDV] Life Sciences [q-bio], MESH: France, 20I/501Y.V1, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, surveillance, France, mutation, Rapid Communication, Demography
Abstract

International audience; The emergence of SARS-CoV-2 variant 20I/501Y.V1 (VOC-202012/1 or GR/501Y.V1) is concerning given its increased transmissibility. We reanalysed 11,916 PCR-positive tests (41% of all positive tests) performed on 7-8 January 2021 in France. The prevalence of 20I/501Y.V1 was 3.3% among positive tests nationwide and 6.9% in the Paris region. Analysing the recent rise in the prevalence of 20I/501Y.V1, we estimate that, in the French context, 20I/501Y.V1 is 52-69% more transmissible than the previously circulating lineages, depending on modelling assumptions.

Published
2021

19. Seroprevalence of chikungunya virus infection among HIV-infected adults in French Caribbean Islands of Martinique and Guadeloupe in 2015: A cross-sectional study

Author

Curlier, Elodie, primary, Fagour, Laurence, additional, Herrmann-Storck, Cécile, additional, Staelen, Adrien, additional, Vingadassalom, Ingrid, additional, Breurec, Sébastien, additional, Abel, Sylvie, additional, Pierre-François, Sandrine, additional, Jean-Marie, Janick, additional, Laouénan, Cédric, additional, Césaire, Raymond, additional, Hoen, Bruno, additional, and Cabié, André, additional

Published
2021
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20. Is Chikungunya Virus Infection an Independent Risk Factor for 2-Year Mortality in Older Afro-Caribbean Subjects?

Author

Godaert, Lidvine, Nicolon, Camille, Najioullah, Fatiha, Kanagaratnam, Lukshe, Césaire, Raymond, and Dramé, Moustapha

Subjects
hospital admission, elderly people, Infection and Drug Resistance, Chikungunya, survival, Original Research
Abstract

Lidvine Godaert,1 Camille Nicolon,2 Fatiha Najioullah,3 Lukshe Kanagaratnam,4 Raymond Césaire,3,5 Moustapha Dramé5,6 1Department of Geriatrics, General Hospital of Valenciennes, Valenciennes, France; 2Department of Geriatrics, Hospital of Marennes, Marennes, France; 3Department of Virology, University Hospitals of Martinique, Fort-de-France, Martinique; 4Department of Research and Public Health, University Hospitals of Reims, Reims, France; 5Faculty of Medicine, University of French West Indies, Fort-de-France, Martinique; 6Department of Research and Innovation, University Hospitals of Martinique, Fort-de-France, MartiniqueCorrespondence: Moustapha DraméDepartment of Research and Innovation - CS 90632, University Hospitals of Martinique - Pierre Zobda-Quitman Hospital, Fort-de-France 97261, MartiniqueTel +596 596 559769Email moustapha.drame@chu-martinique.frPurpose: The aim of this study was to investigate whether Chikungunya virus infection (CVI) was an independent risk factor for 2-year mortality in Afro-Caribbean subjects aged 65 years or older.Patients and methods: A retrospective cohort study was performed from January 2014 to December 2016 in the University Hospital of Martinique. Subjects aged ≥ 65 years admitted to the hospital were included. Baseline characteristics and concurrent manifestations at admission were collected. Subjects were followed up by phone for 2 years.Results: A total of 687 old Afro-Caribbean subjects (80.4± 8.0 years) were included: 467 positive for CVI (Chik+) and 220 negative for CVI (Chik-). During the follow-up, 180 (26.2%) died. The proportion of deaths was higher among Chik- (40.9%) than among Chik+ subjects (21.6%) (p< 0.0001). By multivariable analysis, when adjusted for age polyarthralgia, neurological troubles, cardiovascular disorders, absence of neutrophilia, thrombocytopenia, hypernatremia, and hospital stay, Chik+ subjects had significantly higher survival rates (HR: 0.58; 95% CI: 0.40– 0.85) than Chik- ones.Conclusion: Within the two years following hospital admission of subjects aged ≥ 65 years or older, Chik+ subjects had significantly higher survival rates than Chik- ones.Keywords: Chikungunya, survival, elderly people, hospital admission

Published
2020

27. Increasing prevalence and local transmission of non-B HIV-1 subtypes in the French Antilles and French Guiana between 1995 and 2018

Author

Bello, Gonzalo, primary, Delatorre, Edson, additional, Lacoste, Vincent, additional, Darcissac, Edith, additional, Herrmann-Storck, Cécile, additional, Tressières, Benoit, additional, Cabras, Ornella, additional, Lamaury, Isabelle, additional, Cabié, André, additional, Visseaux, Benoit, additional, Chaix, Marie-Laure, additional, Descamps, Diane, additional, Césaire, Raymond, additional, Nacher, Mathieu, additional, and Dos Santos, Georges, additional

Published
2020
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31. Chapitre 35 : HTLV

Author

ANTOINE, Gessain, CASSAR, Olivier, LEZIN, Agnes, CÉSAIRE, Raymond, Institut Pasteur [Paris], CHU de la Martinique [Fort de France], Thomas Mourez, Sonia Burrel, David Boutolleau, Sylvie Pillet, and Institut Pasteur [Paris] (IP)

Subjects
[SDV]Life Sciences [q-bio], [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

34. Assessing Zika Virus Transmission Within Households During an Outbreak in Martinique, 2015–2016

Author

Cousien, Anthony, primary, Abel, Sylvie, additional, Monthieux, Alice, additional, Andronico, Alessio, additional, Calmont, Isabelle, additional, Cervantes, Minerva, additional, Césaire, Raymond, additional, Gallian, Pierre, additional, de Lamballerie, Xavier, additional, Laouénan, Cédric, additional, Najioullah, Fatiha, additional, Pierre-François, Sandrine, additional, Pircher, Mathilde, additional, Salje, Henrik, additional, ten Bosch, Quirine A, additional, Cabié, André, additional, and Cauchemez, Simon, additional

Published
2019
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36. Increased proviral load in HTLV-1-infected patients with rheumatoid arthritis or connective tissue disease

Author

Olindo Stéphane, Lagathu Gisèle, Dantin Fabienne, Lézin Agnès, Yakova Maria, Jean-Baptiste Georges, Arfi Serge, and Césaire Raymond

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background Human T-lymphotropic virus type 1 (HTLV-1) proviral load is related to the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and has also been shown to be elevated in the peripheral blood in HTLV-1-infected patients with uveitis or alveolitis. Increased proliferation of HTLV-1-infected cells in, or migration of such cells into, the central nervous system is also seen in HAM/TSP. In the present study, we evaluated the proviral load in a cohort of HTLV-1-infected patients with arthritic conditions. Results HTLV-1 proviral load in the peripheral blood from 12 patients with RA and 6 patients with connective tissue disease was significantly higher than that in matched asymptomatic HTLV-1 carriers, but similar to that in matched HAM/TSP controls. HAM/TSP was seen in one-third of the HTLV-1-infected patients with RA or connective tissue disease, but did not account for the higher proviral load compared to the asymptomatic carrier group. The proviral load was increased in the synovial fluid and tissue from an HTLV-1-infected patient with RA, the values suggesting that the majority of infiltrated cells were HTLV-1-infected. In the peripheral blood from HTLV-1-infected patients with RA or connective tissue disease, HTLV-1 proviral load correlated with the percentages of memory CD4+ T cells and activated T cells, and these percentages were shown to be markedly higher in the synovial fluid than in the peripheral blood in an HTLV-1-infected patient with RA. Conclusions These biological findings are consistent with a role of the retrovirus in the development of arthritis in HTLV-1-infected patients. A high level of HTLV-1-infected lymphocytes in the peripheral blood and their accumulation in situ might play a central role in the pathogenesis of HTLV-1-associated inflammatory disorders. Alternatively, the autoimmune arthritis, its etiological factors or treatments might secondarily enhance HTLV-1 proviral load.

Published
2005
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37. Prevalence of chronic chikungunya and associated risks factors in the French West Indies (La Martinique): A prospective cohort study.

Author

Bertolotti, Antoine, Thioune, Marême, Abel, Sylvie, Belrose, Gilda, Calmont, Isabelle, Césaire, Raymond, Cervantes, Minerva, Fagour, Laurence, Javelle, Émilie, Lebris, Catherine, Najioullah, Fatiha, Pierre-François, Sandrine, Rozé, Benoît, Vigan, Marie, Laouénan, Cédric, and Cabié, André

Subjects
CHIKUNGUNYA, CHIKUNGUNYA virus, LONGITUDINAL method, COHORT analysis, ALPHAVIRUS diseases, TENOSYNOVITIS, UNIVARIATE analysis
Abstract

Background: The chikungunya virus (CHIKV) is a re-emerging alphavirus that can cause chronic and potentially incapacitating rheumatic musculoskeletal disorders known as chronic chikungunya arthritis (CCA). We conducted a prospective cohort study of CHIKV-infected subjects during the 2013 chikungunya outbreak in Martinique. The aim of this study was to assess the prevalence of CCA at 12 months and to search for acute phase factors significantly associated with chronicity. Methodology/Principal findings: A total of 193 patients who tested positive for CHIKV RNA via qRT-PCR underwent clinical investigations in the acute phase (<21 days), and then 3, 6, and 12 months after inclusion. The Asian lineage was identified as the circulating genotype. A total of 167 participants were classified as either with or without CCA, and were analyzed using logistic regression models. The overall prevalence of CCA at 12 months was 52.1% (95%CI: 44.5–59.7). In univariate analysis, age (RD 9.62, 95% CI, 4.87;14.38, p<0.0001), female sex (RD 15.5, 95% CI, 1.03;30.0, p = 0.04), headache (RD 15.42, 95% CI, 0.65;30.18 p = 0.04), vertigo (RD 15.33, 95% CI, 1.47;29.19, p = 0.03), vomiting (RD 12.89, 95% CI, 1.54;24.24, p = 0.03), dyspnea (RD 13.53, 95% CI, 0.73;26.33, p = 0.04), intravenous rehydration (RD -16.12, 95% CI, -31.58; -0.66 p = 0.04) and urea (RD 0.66, 95% CI, 0.12;1.20, p = 0.02) were significantly associated with the development of CCA. For the subpopulation with data on joint involvement in the acute phase, the risk factors significantly associated with CCA were at least one 1 enthesitis (RD 16.7, 95%CI, 2.8; 30.7, p = 0.02) and at least one tenosynovitis (RD 16.8, 95% CI, 1.4–32.2, p = 0.04). Conclusions: This cohort study conducted in Martinique confirms that CCA is a common complication of acute chikungunya disease. Our analysis emphasized the importance of age and female sex for CCA occurrence, and highlighted the aggravating role of dehydration during the acute phase. Early and adequate hydration were found to reduce the risk chronic chikungunya disorders. Trial registration: clinicaltrials.gov (NCT01099852). Author summary: Chikungunya is a tropical, mosquito-borne virus that has been re-emerging in the last decade. It has caused major epidemics in recent years, including in Reunion Island and in Southeast Asia. Nearly 2.5 billion people around the world are at risk of contracting the virus. In the acute phase of the illness, patients experience a flu-like syndrome with fever, headache, myalgia, rash, and severe arthralgia. These symptoms can persist for several months in some patients, and can lead to significant functional disability. During the 2013 epidemic in Martinique, we followed nearly 200 patients who had contracted chikungunya. More than half of the patients had a chronic form of the disease—mainly women over 50 years of age. Our statistical analyses indicate that poor hydration in the acute phase is a risk factor for developing chronic rheumatism. This suggests that, in the context of a chikungunya epidemic, patients should drink plenty of fluids as soon as the first symptoms appear. [ABSTRACT FROM AUTHOR]

Published
2020
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40. Outbreak of Chikungunya in the French Caribbean Islands of Martinique and Guadeloupe: Findings from a Hospital-Based Surveillance System (2013–2015)

Author

Dorléans, Frédérique, primary, Hoen, Bruno, additional, Najioullah, Fatiha, additional, Herrmann-Storck, Cécile, additional, Schepers, Kinda Maria, additional, Abel, Sylvie, additional, Lamaury, Isabelle, additional, Fagour, Laurence, additional, Césaire, Raymond, additional, Guyomard, Stéphanie, additional, Troudard, Ruth, additional, Adélaïde, Yvette, additional, Romagne, Marie-José, additional, Davidas, Magguy, additional, Rochais, Séverine, additional, Boa, Sylvie, additional, de Saint-Alary, Frédérique, additional, Preira, Annabel, additional, Saint-Martin, Patrick, additional, Vaidie, Amandine, additional, Melin, Mathilde, additional, Daudens-Vaysse, Elise, additional, Rosine, Jacques, additional, Blateau, Alain, additional, Carvalho, Luisiane, additional, Septfons, Alexandra, additional, Paty, Marie-Claire, additional, Leduc, Ghislain, additional, Cassadou, Sylvie, additional, Ledrans, Martine, additional, and Cabié, André, additional

Published
2018
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42. Épidémiologie de l’infection à papillomavirus humains chez les femmes âgées de 20 à 65 ans résidant dans des communes isolées de Guyane française : adapter l’action au territoire

Author

Dufit , Valentin, Adenis, Antoine, Douine, Maylis, Najioullah, Fatiha, Kilie, Odile, Molinié, Vincent, Catherine , Dominique, Thomas, Nadia, Deshayes, Jean-Luc, Brousse, Paul, Carles, Gabriel, Lacoste, Vincent, Césaire, Raymond, Nacher, Mathieu, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Laboratoire de Virologie-Immunologie, Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Service d'anatomopathologie, CHU Fort de France, Service de gynécologie-obstétrique, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Association guyanaise de dépistage organisé des cancers (AGDOC), Département des Centres Délocalisés de Prévention et de Soins, Centre Hospitalier de l'Ouest Guyanais, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), and Fonds européens de développement régional (numéro présage FEDER : 30 814)

Subjects
HPV, Guyane française, Populations isolées, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Génotype, Prévalence
Abstract

National audience; Context – Cervical cancer is the second most frequent cancer of women in French Guiana. Studies have shown that populations living in remote villages in the interior of the territory have early sexual relations and that multiple sexual partnerships are frequent. Hence, the main objective of the study was to determine the prevalence of Human Papilloma Virus (HPV) in these areas.Methods – This multicentric cross sectional study was conducted in women aged 20 to 65 years, living in theremote villages along the Maroni and Oyapock rivers. Women were included on a voluntary basis after beinginformed of the study team schedule through radio address and key opinion leaders.The search for HPV and cytologic examinations were performed on each sample. HPV infection was defined bythe detection of viral DNA using the Greiner Bio One® kit. Cytologic analyses were performed using the 2001Bethesda classification.Results – Overall, 643 women were included in the study. Age-standardized HPV prevalence was 35%. Theprevalence curve by age group showed a U-shaped pattern: women over 50 years had the highest risk of being infected by HPV, followed by women aged 20-29 years. In addition, 26.1% of women with a normal smear test had HPV infection. The most frequent genotypes were HPV52, HPV58, and HPV16. On interpretable smears 1.16% of women had high grade superficial intra-epithelial (HSIL) lesions.Conclusions – The standardized prevalence of HPV in French Guiana is among the highest in the world. HSILcytological lesions were nearly 4 times more frequent than in the Île-de-France region. Given the importance of the incidence of cervical cancer in French Guiana, these results suggest it may be preferable to use HPV testing than cytology. Vaccination against HPV, preferably with the new nonavalent vaccine seems an appropriate prevention measure. However, this intervention will be a challenge to implement in this region where a significant proportion of the population is not covered by health insurance.; Contexte – Le cancer du col de l’utérus est le deuxième cancer féminin le plus fréquent en Guyane française.Des études ont montré que les populations résidant dans les communes isolées de l’intérieur du départementdébutent leur vie sexuelle de façon précoce et que le multipartenariat sexuel y est fréquent. Dans ce contexte, l’objectif principal de cette étude était de déterminer la prévalence de l’infection à papillomavirus humains (HPV) dans ces zones.Méthodes – Cette étude transversale multicentrique a été conduite auprès des femmes âgées de 20 à 65 ansrésidant dans les communes isolées des fleuves Maroni et Oyapock. Les femmes étaient incluses sur la basedu volontariat après avoir été informées du passage de l’équipe de l’étude via la radio locale et par les leadersd’opinion. La recherche d’infection à HPV et les analyses cytologiques ont été réalisées sur chaque prélèvement. L’infection à HPV était définie par la détection d’ADN viral par le kit de dépistage Greiner Bio One®. Les analyses cytologiques ont été décrites selon la classification de Bethesda 2001.Résultats – Au total, 643 femmes ont été incluses. La prévalence de l’infection à HPV, standardisée sur l’âge,était de 35%. La courbe de prévalence par classe d’âge présentait une forme en U : les femmes de plus de50 ans avaient le plus haut risque d’être infectées par HPV, suivies par les femmes âgées de 20 à 29 ans.Par ailleurs, 26,1% des femmes ayant un frottis normal étaient infectées par le HPV. Les génotypes les plusfréquents étaient HPV52, HPV58 et HPV16. Sur les frottis interprétables, 1,16% des femmes avaient des lésions de haut grade (type HSIL).Conclusions – Le taux standardisé de prévalence de l’infection par le HPV en Guyane est parmi les plus élevésau monde. Les lésions cytologiques de type HSIL étaient près de 4 fois plus fréquentes qu’en Île-de-France.Étant donné l’importance de l’incidence du cancer du col de l’utérus en Guyane, ces résultats montrent qu’il est peut être préférable d’utiliser le test HPV plutôt que la cytologie. La vaccination anti-HPV, de préférence avec le nouveau vaccin nonavalent, semble être une mesure de prévention appropriée. Pour autant, cela reste un challenge de mettre en oeuvre ces interventions dans cette région où une part importante de la population n’a pas d’assurance maladie.

Published
2016

43. The epidemiology of human papilloma virus in women aged 20-65 years living in remote villages in French Guiana: adapting interventions to the territory

Author

Dufit , Valentin, Adenis, Antoine, Douine, Maylis, Najioullah, Fatiha, Kilie, Odile, Molinié, Vincent, Catherine , Dominique, Thomas, Nadia, Deshayes, Jean-Luc, Brousse, Paul, Carles, Gabriel, Lacoste, Vincent, Césaire, Raymond, Nacher, Mathieu, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Laboratoire de Virologie-Immunologie, Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Service d'anatomopathologie, CHU Fort de France, Service de gynécologie-obstétrique, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Association guyanaise de dépistage organisé des cancers (AGDOC), Département des Centres Délocalisés de Prévention et de Soins, Centre Hospitalier de l'Ouest Guyanais, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Fonds européens de développement régional (numéro présage FEDER : 30 814), and ADENIS, ANTOINE

Subjects
HPV, Guyane française, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Populations isolées, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Génotype, Prévalence
Abstract

Context – Cervical cancer is the second most frequent cancer of women in French Guiana. Studies have shown that populations living in remote villages in the interior of the territory have early sexual relations and that multiple sexual partnerships are frequent. Hence, the main objective of the study was to determine the prevalence of Human Papilloma Virus (HPV) in these areas.Methods – This multicentric cross sectional study was conducted in women aged 20 to 65 years, living in theremote villages along the Maroni and Oyapock rivers. Women were included on a voluntary basis after beinginformed of the study team schedule through radio address and key opinion leaders.The search for HPV and cytologic examinations were performed on each sample. HPV infection was defined bythe detection of viral DNA using the Greiner Bio One® kit. Cytologic analyses were performed using the 2001Bethesda classification.Results – Overall, 643 women were included in the study. Age-standardized HPV prevalence was 35%. Theprevalence curve by age group showed a U-shaped pattern: women over 50 years had the highest risk of being infected by HPV, followed by women aged 20-29 years. In addition, 26.1% of women with a normal smear test had HPV infection. The most frequent genotypes were HPV52, HPV58, and HPV16. On interpretable smears 1.16% of women had high grade superficial intra-epithelial (HSIL) lesions.Conclusions – The standardized prevalence of HPV in French Guiana is among the highest in the world. HSILcytological lesions were nearly 4 times more frequent than in the Île-de-France region. Given the importance of the incidence of cervical cancer in French Guiana, these results suggest it may be preferable to use HPV testing than cytology. Vaccination against HPV, preferably with the new nonavalent vaccine seems an appropriate prevention measure. However, this intervention will be a challenge to implement in this region where a significant proportion of the population is not covered by health insurance., Contexte – Le cancer du col de l’utérus est le deuxième cancer féminin le plus fréquent en Guyane française.Des études ont montré que les populations résidant dans les communes isolées de l’intérieur du départementdébutent leur vie sexuelle de façon précoce et que le multipartenariat sexuel y est fréquent. Dans ce contexte, l’objectif principal de cette étude était de déterminer la prévalence de l’infection à papillomavirus humains (HPV) dans ces zones.Méthodes – Cette étude transversale multicentrique a été conduite auprès des femmes âgées de 20 à 65 ansrésidant dans les communes isolées des fleuves Maroni et Oyapock. Les femmes étaient incluses sur la basedu volontariat après avoir été informées du passage de l’équipe de l’étude via la radio locale et par les leadersd’opinion. La recherche d’infection à HPV et les analyses cytologiques ont été réalisées sur chaque prélèvement. L’infection à HPV était définie par la détection d’ADN viral par le kit de dépistage Greiner Bio One®. Les analyses cytologiques ont été décrites selon la classification de Bethesda 2001.Résultats – Au total, 643 femmes ont été incluses. La prévalence de l’infection à HPV, standardisée sur l’âge,était de 35%. La courbe de prévalence par classe d’âge présentait une forme en U : les femmes de plus de50 ans avaient le plus haut risque d’être infectées par HPV, suivies par les femmes âgées de 20 à 29 ans.Par ailleurs, 26,1% des femmes ayant un frottis normal étaient infectées par le HPV. Les génotypes les plusfréquents étaient HPV52, HPV58 et HPV16. Sur les frottis interprétables, 1,16% des femmes avaient des lésions de haut grade (type HSIL).Conclusions – Le taux standardisé de prévalence de l’infection par le HPV en Guyane est parmi les plus élevésau monde. Les lésions cytologiques de type HSIL étaient près de 4 fois plus fréquentes qu’en Île-de-France.Étant donné l’importance de l’incidence du cancer du col de l’utérus en Guyane, ces résultats montrent qu’il est peut être préférable d’utiliser le test HPV plutôt que la cytologie. La vaccination anti-HPV, de préférence avec le nouveau vaccin nonavalent, semble être une mesure de prévention appropriée. Pour autant, cela reste un challenge de mettre en oeuvre ces interventions dans cette région où une part importante de la population n’a pas d’assurance maladie.

Published
2016

45. Screening test for neutralizing antibodies against yellow fever virus, based on a flavivirus pseudotype

Author

Mercier-Delarue, Séverine, primary, Durier, Christine, additional, Colin de Verdière, Nathalie, additional, Poveda, Jean-Dominique, additional, Meiffrédy, Vincent, additional, Fernandez Garcia, Maria Dolores, additional, Lastère, Stéphane, additional, Césaire, Raymond, additional, Manuggera, Jean-Claude, additional, Molina, Jean-Michel, additional, Amara, Ali, additional, and Simon, François, additional

Published
2017
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47. Late miscarriage: another Zika concern?

Author

Schaub, Bruno, primary, Monthieux, Alice, additional, Najioullah, Fatiha, additional, Harte, Caroline, additional, Césaire, Raymond, additional, Jolivet, Eugénie, additional, and Voluménie, Jean-Luc, additional

Published
2016
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48. High prevalence of human papillomavirus infection in HIV-infected women living in French Antilles and French Guiana.

Author

Abel, Sylvie, Najioullah, Fatiha, Voluménie, Jean-Luc, Accrombessi, Laetitia, Carles, Gabriel, Catherine, Dominique, Chiappetta, Déborah, Clavel, Cyril, Codjo-Sodokine, Akua, El Guedj, Myriam, Jean-Marie, Janick, Molinié, Vincent, Pierre-François, Sandrine, Stegmann-Planchard, Sofia, Vantilcke, Vincent, Vaz, Tania, Nacher, Mathieu, Cabié, André, Césaire, Raymond, and null, null

Subjects
PAPILLOMAVIRUSES, PAPILLOMAVIRUS diseases, HIV infections, HUMAN papillomavirus vaccines, ART therapy, VIRUS diseases, SEXUALLY transmitted diseases
Abstract

An association between HIV infection and cervical cancer, a major public health issue worldwide, has been reported. The aim of this study was to estimate the prevalence of human papillomavirus (HPV) infection and the distribution of HPV genotypes in HIV-infected women living in French Antilles and Guiana and to determine HIV-related characteristics associated with HPV infection. This cross-sectional study included 439 HIV-infected women who were followed between January 2011 and May 2014. Variables related to HIV infections were collected, and cervical samples were analysed to determine HPV genotypes. The median age of the population was 46 years. Estimated prevalence of HPV and high-risk (HR)-HPV infection were 50.1% IC95 [45.4–54.7] and 42% IC95 [37.3–46.6], respectively. HR-HPV 16, 52, 53 or intermediate risk-HPV-68 were found in 25% to 30% of the HPV-infected patients. Gynaecological screening revealed abnormal cervical smear in 24% and 42% of HR-HPV-negative and HPV-positive women, respectively (p = 0.003). Approximately 90% of women were on antiretroviral therapy (ART). Demographic characteristics associated with a higher prevalence of HPV infection included alcohol consumption. Regarding HIV-related characteristics, current therapy on ART, its duration, and undetectable plasma concentrations of RNA-HIV1 were associated with a lower risk of HPV infection. Infection rate with HR-HPV was higher than what is commonly reported in HIV-negative women worldwide and was more likely in women with incomplete HIV suppression. These results highlight the need for supporting adherence to ART, cervical cytology, HPV testing and HPV vaccination. [ABSTRACT FROM AUTHOR]

Published
2019
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