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2 results on '"C Günthert"'

1. Oncoplastic breast consortium recommendations for mastectomy and whole breast reconstruction in the setting of post-mastectomy radiation therapy

Author

Weber, W.P. Shaw, J. Pusic, A. Wyld, L. Morrow, M. King, T. Mátrai, Z. Heil, J. Fitzal, F. Potter, S. Rubio, I.T. Cardoso, M.-J. Gentilini, O.D. Galimberti, V. Sacchini, V. Rutgers, E.J.T. Benson, J. Allweis, T.M. Haug, M. Paulinelli, R.R. Kovacs, T. Harder, Y. Gulluoglu, B.M. Gonzalez, E. Faridi, A. Elder, E. Dubsky, P. Blohmer, J.-U. Bjelic-Radisic, V. Barry, M. Hay, S.D. Bowles, K. French, J. Reitsamer, R. Koller, R. Schrenk, P. Kauer-Dorner, D. Biazus, J. Brenelli, F. Letzkus, J. Saccilotto, R. Joukainen, S. Kauhanen, S. Karhunen-Enckell, U. Hoffmann, J. Kneser, U. Kühn, T. Kontos, M. Tampaki, E.C. Carmon, M. Hadar, T. Catanuto, G. Garcia-Etienne, C.A. Koppert, L. Gouveia, P.F. Lagergren, J. Svensjö, T. Maggi, N. Kappos, E.A. Schwab, F.D. Castrezana, L. Steffens, D. Krol, J. Tausch, C. Günthert, A. Knauer, M. Katapodi, M.C. Bucher, S. Hauser, N. Kurzeder, C. Mucklow, R. Tsoutsou, P.G. Sezer, A. Çakmak, G.K. Karanlik, H. Fairbrother, P. Romics, L. Montagna, G. Urban, C. Walker, M. Formenti, S.C. Gruber, G. Zimmermann, F. Zwahlen, D.R. Kuemmel, S. El-Tamer, M. Vrancken Peeters, M.J. Kaidar-Person, O. Gnant, M. Poortmans, P. de Boniface, J. and Weber, W.P. Shaw, J. Pusic, A. Wyld, L. Morrow, M. King, T. Mátrai, Z. Heil, J. Fitzal, F. Potter, S. Rubio, I.T. Cardoso, M.-J. Gentilini, O.D. Galimberti, V. Sacchini, V. Rutgers, E.J.T. Benson, J. Allweis, T.M. Haug, M. Paulinelli, R.R. Kovacs, T. Harder, Y. Gulluoglu, B.M. Gonzalez, E. Faridi, A. Elder, E. Dubsky, P. Blohmer, J.-U. Bjelic-Radisic, V. Barry, M. Hay, S.D. Bowles, K. French, J. Reitsamer, R. Koller, R. Schrenk, P. Kauer-Dorner, D. Biazus, J. Brenelli, F. Letzkus, J. Saccilotto, R. Joukainen, S. Kauhanen, S. Karhunen-Enckell, U. Hoffmann, J. Kneser, U. Kühn, T. Kontos, M. Tampaki, E.C. Carmon, M. Hadar, T. Catanuto, G. Garcia-Etienne, C.A. Koppert, L. Gouveia, P.F. Lagergren, J. Svensjö, T. Maggi, N. Kappos, E.A. Schwab, F.D. Castrezana, L. Steffens, D. Krol, J. Tausch, C. Günthert, A. Knauer, M. Katapodi, M.C. Bucher, S. Hauser, N. Kurzeder, C. Mucklow, R. Tsoutsou, P.G. Sezer, A. Çakmak, G.K. Karanlik, H. Fairbrother, P. Romics, L. Montagna, G. Urban, C. Walker, M. Formenti, S.C. Gruber, G. Zimmermann, F. Zwahlen, D.R. Kuemmel, S. El-Tamer, M. Vrancken Peeters, M.J. Kaidar-Person, O. Gnant, M. Poortmans, P. de Boniface, J.

Abstract

Aim: Demand for nipple- and skin- sparing mastectomy (NSM/SSM) with immediate breast reconstruction (BR) has increased at the same time as indications for post-mastectomy radiation therapy (PMRT) have broadened. The aim of the Oncoplastic Breast Consortium initiative was to address relevant questions arising with this clinically challenging scenario. Methods: A large global panel of oncologic, oncoplastic and reconstructive breast surgeons, patient advocates and radiation oncologists developed recommendations for clinical practice in an iterative process based on the principles of Delphi methodology. Results: The panel agreed that surgical technique for NSM/SSM should not be formally modified when PMRT is planned with preference for autologous over implant-based BR due to lower risk of long-term complications and support for immediate and delayed-immediate reconstructive approaches. Nevertheless, it was strongly believed that PMRT is not an absolute contraindication for implant-based or other types of BR, but no specific recommendations regarding implant positioning, use of mesh or timing were made due to absence of high-quality evidence. The panel endorsed use of patient-reported outcomes in clinical practice. It was acknowledged that the shape and size of reconstructed breasts can hinder radiotherapy planning and attention to details of PMRT techniques is important in determining aesthetic outcomes after immediate BR. Conclusions: The panel endorsed the need for prospective, ideally randomised phase III studies and for surgical and radiation oncology teams to work together for determination of optimal sequencing and techniques for PMRT for each patient in the context of BR © 2022 The Authors

Published
2022

2. Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial

Author

John R. Ingram, H K Bell, Gudula Kirtschig, B Walker, Fiona Antony, M Walsh, Eva-B. Bröcker, Ingrid Salvary, J Wee, Emilia Duarte-Williamson, H Santander, Kathy Taghipour, David Gawkrodger, Enno Schmidt, Sam Gibbs, Alison M Layton, Michael Sticherling, J Adams, M Vatve, Joanne R Chalmers, Hywel C Williams, Fiona Craig, S Blackford, A Carmichael, Walter Bottomley, Adzura Azam, Chris Lovell, Karen E. Harman, Margaret Childs, Alexander Vincent Anstey, K. Hussain, Marinella Nik, C Günthert, A. Chapman, N. van Beek, Andrew M Wright, Rainer Hügel, C Barnard, Indre Verpetinske, K Davies, Thomas A. Luger, A Omerod, Karen Gibbon, Alex Waters, V Akhras, Robert Charles-Holmes, Shyamal Wahie, John C. English, James Mason, R.R. Coelho, Girish Khandubhai Patel, Robert Ellis, Jane C. Sterling, A Lloyd Lavery, Thomas R. Godec, Fenella Wojnarowska, Jane Ravenscroft, Richard Groves, H Malhomme, Kerstin Steinbrink, Andrew J. Nunn, Regine Gläser, Emma Veysey, Adam Ferguson, V Lewis, Diane Whitham, V Venning, M Westmoreland, G Wong, Chris Bower, N. Hepburn, C Thomas, P J Hampton, R. Wachsmuth, Andrew Ilchyshyn, Nick J. Levell, M G S Dunnill, S. Walton, and R Rallan

Subjects
Adult, Male, medicine.medical_specialty, Pemphigoid, medicine.medical_treatment, Prednisolone, RL, Administration, Oral, Equivalence Trials as Topic, law.invention, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Germany, Internal medicine, Pemphigoid, Bullous, medicine, Initial treatment, Humans, skin and connective tissue diseases, Glucocorticoids, Aged, Aged, 80 and over, Doxycycline, Medicine(all), Clinical Trials as Topic, integumentary system, business.industry, Standard treatment, General Medicine, Articles, Middle Aged, medicine.disease, R1, Dermatology, United Kingdom, Anti-Bacterial Agents, Treatment Outcome, 030220 oncology & carcinogenesis, Female, Bullous pemphigoid, business, Adjuvant, medicine.drug
Abstract

BACKGROUND: Bullous pemphigoid is a blistering skin disorder with increased mortality. We tested whether a strategy of starting treatment with doxycycline gives acceptable short-term blister control while conferring long-term safety advantages over starting treatment with oral corticosteroids. METHODS: We did a pragmatic, multicentre, parallel-group randomised controlled trial of adults with bullous pemphigoid (three or more blisters at two or more sites and linear basement membrane IgG or C3). Participants were randomly assigned to doxycycline (200 mg per day) or prednisolone (0·5 mg/kg per day) using random permuted blocks of randomly varying size, and stratified by baseline severity (3-9, 10-30, and >30 blisters for mild, moderate, and severe disease, respectively). Localised adjuvant potent topical corticosteroids (

Published
2017

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