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9 results on '"C.D. Dijkstra"'

1. Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE

Author

S. Dijkstra, G. Kooij, R. Verbeek, S.M.A. van der Pol, S. Amor, E.E. Geisert, Jr., C.D. Dijkstra, J.M. van Noort, and H.E. de Vries

Subjects
Tetraspanins, CD81, Multiple sclerosis, Transendothelial migration, Therapeutic antibodies, EAE, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Leukocyte infiltration is a key step in the development of demyelinating lesions in multiple sclerosis (MS), and molecules mediating leukocyte-endothelial interactions represent prime candidates for the development of therapeutic strategies. Here we studied the effects of blocking the integrin-associated tetraspanin CD81 in in vitro and in vivo models for MS. In an in vitro setting mAb against CD81 significantly reduced monocyte transmigration across brain endothelial cell monolayers, both in rodent and human models. Interestingly, leukocyte as well as endothelial CD81 was involved in this inhibitory effect. To assess their therapeutic potential, CD81 mAb were administered to mice suffering from experimental autoimmune encephalomyelitis (EAE). We found that Eat2, but not 2F7 mAb directed against mouse CD81 significantly reduced the development of neurological symptoms of EAE when using a preventive approach. Concomitantly, Eat2 treated animals showed reduced inflammation in the spinal cord. We conclude that CD81 represents a potential therapeutic target to interfere with leukocyte infiltration and ameliorate inflammatory neurological damage in MS.

Published
2008
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2. Modelling Multiple Sclerosis In Vitro and the Influence of Activated Macrophages

Author

C.E. Teunissen, E.J.F. Vereyken, and C.D. Dijkstra

Subjects
Pathology, medicine.medical_specialty, Microglia, business.industry, Multiple sclerosis, Central nervous system, Disease, medicine.disease, Oligodendrocyte, Astrogliosis, Glial scar, medicine.anatomical_structure, medicine, Remyelination, business
Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). The prevalence of MS is approximately 2 million people worldwide, with an incidence of about 1:1000 in Europe and Northern America, and women are affected more often compared to men, at a ratio of approximately 2:1. It is the most common cause of neurological disability among young adults with an onset generally between 20 and 40 years of age [Pugliatti et al., 2002]. The major neuropathological hallmarks of MS are demyelinating lesions associated with perivascular infiltrates, consisting of macrophages/microglia and lymphocytes. The lesions are characterized by destruction of myelin sheaths, oligodendrocyte death, axonal damage and glial scar formation, called astrogliosis. Demyelination is a central event in MS pathology. Although some remyelination occurs, it ultimately fails [Franklin, 2002]. The cause of the remyelination failure is not clear, although several processes have been suggested to play a role [Franklin and Ffrench-Constant, 2008; Wolswijk, 2002; John et al., 2002]. Not only processes behind remyelination failure remain elusive, also the cellular mechanisms behind the demyelination and axonal damage are largely unknown. Modelling MS both in animals and in vitro could help with understanding this. This chapter will focus on MS pathology and the models that exist for investigating this disease, especially zooming in on in vitro models.

Published
2011

4. LIST OF CONTRIBUTORS

Author

B. Albini, B. Adler, H. Adler, R. Ameratunga, A.O. Anderson, A.E. Andrews, T.P. Arstila, M. Bailey, H.J. Barnes, H. Bazin, G. Bertoni, B. Blacklaws, N.A. Bos, M. Brait, J.E. Butler, R.N.P. Cahill, S.D. Carter, J.-Y. Cesbron, J. Charlemagne, B. Charley, C. Cunningham, B. Cukrowska, M.R. Daha, P.M. Dammers, G.J. Deenen, M.P. Defresne, N. Delhem, S.L. Demaries, D. Desmecht, C.D. Dijkstra, A.E. Ellis, R. Fatzer, P.J. Felsburg, O.J. Fletcher, A. Fluri, D.L. Foss, P. Gianello, U. Giger, B. Goddeeris, A. Govaerts, C.K. Grant, D.L. Greiner, P.J. Griebel, U. Grimholt, H. Groen, B. Hague, D. Haig, K. Hala, R. Hamers, R.J. Hanken, D. Hannant, D.A. Harbour, J. Harlan, R.J. Hawken, W.R. Hein, E. Heinen, S.C. Helfand, T. Hermann, K. Høgåsen, H. Hogenesch, I. Hordvik, D.W. Horohov, C. Howard, T. Hünig, A. Husband, S.W. Hüttner, M.N. Hylkema, G.A. Ingram, N. Ishiguro, S.B. Jakowlew, S.H.M. Jeurissen, E. Joosten, T. Jørgensen, T.W. Jungi, M.H. Kaplan, J. Kaufman, W.G. Kimpton, K.L. Knight, C. Koch, M. Komatsu, T.L. Koppenheffer, G.S. Krakowka, F.G.M. Kroese, T. Landsverk, D. Lanning, D. Latinne, V. Leblond, C. Leutenegger, J.K. Levy, H. Lewin, Ø. Lie, H.S. Lillehoj, D. Llanes, J.S. Lumsden, D.P. Lunn, J. Lunney, H. Lutz, N. MacHugh, J.F. Maddox, R.G. Mage, H.M. Martin, S. McClure, T.J. McConnell, W.T. McCormack, P.P. McCullagh, D. McKeever, B. Mertens, N.W. Miller, J.F. Modiano, B.P. Morgan, D.C. Morizot, M.P. Moutschen, M.P. Murtaugh, S. Muyldermans, J. Naessens, A.D. Nash, T.C. Nguyen, P. Nieuwenhuis, G. Obexer-Ruff, R. Pabst, P.P. Pastoret, N.C. Pedersen, T.L. Pertile, M.D. Pescovitz, E. Peterhans, L. Pilstöm, J. Plachy, C. McL. Press, R. Pu, C. Ramamoorthy, M.J.H. Ratcliffe, S. Rautenschlein, M. Reinacher, J.W. Ritchey, B. Robertsen, L.S. Rodkey, J.H.W.M. Rombout, J. Roth, H.J. Rothkötter, J. Rozing, K.A. Schat, A. Seto, S. Sharar, J.M. Sharma, J. Sinkora, N. Sittisombut, M. Soares, P. Sopp, C.R. Stokes, M. Suter, H. Tabel, M.F. Tatner, R.G. Tissot, H. Tlaskalová-Hogenová, P. Toivanen, M.B. Tompkins, W.A.F. Tompkins, N.E. Torres-Nagel, A. Tournefier, I. Trebichavsky, E. Tucker, J. Urbain, O. Vainio, R.H. van den Berg, T.K. van den Berg, A. van den Broeke, P. van der Meide, M. Vandevelde, E.P. van Rees, P. Vögeli, J.L. Wagner, P.S. Wakenell, D. Watson, P.D. Weinstein, E.R. Werner, J. Westermann, B.J. Whalen, B.J. Willett, J.A. Winkelstein, R. Winn, J.K. Yamamoto, A.J. Young, and A. Zurbriggen

Published
1998

5. Centrocentral coaptation inhibits microglial activation and prevents changes in substance-P reactivity in the rat spinal cord after a peripheral nerve lesion

Author

W.J.R. van Ouwerkerk, C.D. Dijkstra, T.R. de Haan, and W. Kamphorst

Subjects
business.industry, Substance P, General Medicine, Spinal cord, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Anesthesia, Peripheral nervous system, Medicine, Surgery, Reactivity (chemistry), Neurology (clinical), business, Peripheral nerve lesion
Published
1997

6. Scientific Meeting of Netherlands Society of Neurology Held in Amersfoort, 9th and 10th December 1988

Author

J. Boiten, J. Lodder, M. Limburg, A. Hijdra, J.M.J. Krul, J. van Gijn, R.G.A. Ackerstaff, B.C. Eikelboom, Th. Theodorides, F.E.E. Vermeulen, M.D. Ferrari, H.J. Gijsman, J. Jansen, A. Go, M.A.M. Bomhof, J.W. Hartman, L.A. Hogenhuis, J.G. Kok, C.P. Zwetsloot, J.F.V. Caekebeke, J.C. Jansen, M.S. van der Knaap, J. Valk, C.W.G.M. Frenken, A.C. Declerck, J.B.A.M. Arends, J.H.M. van Eck, W.A.J. Hoefnagels, E.J.A. Gerritsen, O.F. Brouwer, J.H.M. Souverijn, J.H.J. Wokke, F.G.J. Jennekens, H.F.M. Buscher, P. Molenaar, A.E.J. de Jager, T.W. van Weerden, J.M. Minderhoud, J.A.F.M. Luijten, V.T.M. Camps, C.J.A. de Groot, J.W. Manten, C.D. Dijkstra, M.C.T.F.M. de Krom, P.G. Knipschild, A.D.M. Kester, F. Spaans, P.J.M. van der Lugt, Jan C. den Heijer, Ward L.E.M. Bollen, Jelte E. Bos, J. Gert van Dijk, Axel R. Wintzen, Obstetrics and gynaecology, Pediatric surgery, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, and Molecular cell biology and Immunology

Subjects
medicine.medical_specialty, Neurology, business.industry, Family medicine, Ophthalmology, medicine, Surgery, Neurology (clinical), General Medicine, business
Published
1989

9. Book Review / News Item / Erratum

Author

M. Steinitz, E. Nieminen, P.G. Holt, Yasuyuki Akiyama, J. Imai, J.C. Koetsier, J. Wasserman, A. Metwali, A.M. Attallah, Beda M. Stadler, Sarah J. Porter, C.D. Dijkstra, Victoria Wicher, C. de Groot, B. Petrini, C. Stenvinkel, Beda Stadler, Konrad Wicher, T.A. Fleisher, Judah A. Denburg, M. Owhashi, M.R. Alijani, Kenji Uegaki, André Capron, Henk K. Parmentier, J. Riedlinger, A.D. Steinberg, I. Vedin, Ruth Standring, L.-V. von Stedingk, H. Blomgren, T. Abe, S. Hammarström, O.J. Corrado, H.W. Clark, A.K. Schröder, Ronald F. Gruhn, M. Viander, P.J.H. Johansson, T. Sminia, A. Fawzy, E. Valovirta, O. Söder, Alain L. de Weck, Vivienne Spackman, H. Abdelghaffar, Komei Fukui, C.H. Polman, L. Rydlander, E.J. Ruitenberg, Y. Nawa, C.J. Abeyounis, M.H. Kaplan, A. Koivikko, P. Christensen, F. Alghraoui, Carolien de Vries, M.A. Ghoneim, Miwako Ono, F. Milgrom, Fusao Ota, Yasuhiko Satomi, L. Ingeman, R.J. Davies, Yasuo Tanno, E. Gomez, Henk Van Loveren, C. Mazingue, D. Wakelin, T. Vanto, S. Kaise, L.A. Mahmoud, Christoph Walker, T.McP. Brown, G.B. Helfrich, G. Sandberg, R.K. Grencis, A.E. Gharavi, Wolfgang Domzig, and G.A. Stewart

Subjects
medicine.medical_specialty, business.industry, Immunology, Alternative medicine, medicine, Immunology and Allergy, Library science, General Medicine, business
Published
1987

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