1. Atenolol to Treat Intestinal Ischemia and Reperfusion in Rats
- Author
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Afonso Caricati-Neto, M.O. Taha, Djalma José Fagundes, C.E.F. Carmo, G.D. Teixeira, W.T.I. Souza, V.F. Campos, Regiane Miranda-Ferreira, Hugo P. Monteiro, I. T. Gomes, Nabiha Saadi Abrahão Taha, L.A. Silva-Neto, and Edna Frasson de Souza Montero
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,H&E stain ,Ischemia ,Enteric Nervous System ,Potassium Chloride ,Gastrointestinal Agents ,medicine.artery ,Internal medicine ,Occlusion ,Animals ,Medicine ,Superior mesenteric artery ,Rats, Wistar ,Saline ,Transplantation ,business.industry ,Intestinal ischemia ,Organ bath ,Atenolol ,medicine.disease ,Adrenergic beta-1 Receptor Antagonists ,Electric Stimulation ,Rats ,Disease Models, Animal ,Jejunum ,Endocrinology ,Cytoprotection ,Reperfusion Injury ,Anesthesia ,Surgery ,Gastrointestinal Motility ,business ,medicine.drug - Abstract
To study whether treatment with the beta-blocker atenolol (AT) attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rats were treated with AT (1.5 mg · kg −1 , intravenously) or saline solution (SS) prior to I (60 minutes), which was produced by occlusion of the superior mesenteric artery, and/or R (120 minutes). After I or I/R, 2-cm jejunal segments were mounted in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained with hematoxylin and eosin for optical microscopy analysis. Compared to the sham group, jejunal contractions were similar in the I + AT and the I/R + AT groups, but reduced in the I + SS and the I/R + SS groups. The jejunal enteric nerves were damaged in the I + SS and the I/R + SS groups, but not in the I + AT and the I/R + AT. These results suggest that AT may attenuate intestinal dysfunction caused by I and I/R.
- Published
- 2012