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2 results on '"C.H.E. Boel"'

1. Data on a rat infection model to assess porous titanium implant coatings

Author

M. Croes, H. de Visser, B.P. Meij, K. Lietart, B.C.H. van der Wal, H.C. Vogely, A.C. Fluit, C.H.E. Boel, J. Alblas, H. Weinans, and S. Amin Yavari

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390
Abstract

A model is needed to study the effectiveness of different anti-bacterial coatings on complex metal implants in a bone environment. This article shares data on the design of porous titanium implants for intramedullary implantation in the proximal rat tibia. The implant length, diameter and porosity were optimized after testing on cadaveric specimens. This article shares data on which parameters are critical to establish a chronic implant infection in Sprague Dawley rats when using the new implant design. To this end, different strains of Staphylococcus aureus and inoculation doses were investigated.

Published
2018
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2. Hair follicles as a niche of Staphylococcus aureus in the nose; is a more effective decolonisation strategy needed?

Author

C.H.E. Boel, R.L.A.W. Bleys, Ad C. Fluit, J.A. Kummer, and N.J.P. ten Broeke-Smits

Subjects
Microbiology (medical), Male, Staphylococcus aureus, Micrococcaceae, medicine.drug_class, Antibiotics, Mupirocin, Nose, Staphylococcal infections, medicine.disease_cause, Epithelium, Microbiology, chemistry.chemical_compound, medicine, Humans, Antibacterial agent, Aged, Aged, 80 and over, biology, business.industry, General Medicine, Middle Aged, Staphylococcal Infections, biology.organism_classification, medicine.disease, Hair follicle, Immunohistochemistry, Anti-Bacterial Agents, Infectious Diseases, medicine.anatomical_structure, chemistry, Immunology, Carrier State, Female, business, Hair Follicle
Abstract

Staphylococcus aureus is the major cause of surgical site infections, and meticillin-resistant S. aureus (MRSA) is increasingly accounting for infections worldwide. Preventing surgical site infections by screening and decolonising positive patients reduces the number of infections, but does not completely eradicate the risk. A balance between prevention, costs and the chance of mupirocin-resistant S. aureus needs to be evaluated and decolonisation strategies optimised. It is essential to know the site of S. aureus during colonisation. In this study, for the first time the exact location of S. aureus in the human nose was determined using a histological approach. We showed the presence of S. aureus in the cornified layer of squamous epithelium, associated keratin and mucous debris and within hair follicles in the vestibulum nasi. The presence of S. aureus in hair follicles suggests that this could be the niche from which relapses occur after decolonisation. Decolonisation strategies might have to be reconsidered.

Published
2010

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