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To establish a disease risk prediction model based on genetic susceptibility genes and environmental risk factors， which can target high-risk population as early as possible， and intervene in the environmental risk factors in this population. Moreover， accurate screening of genetically susceptible populations can enhance the efficiency of health system. In recent years， with the maturation and cost reduction of high-throughput gene testing， gene testing has been widely used in individual clinical decision-making and will play a more important role in medical and health decision-making. The correlation between genetic testing and disease risk prediction is increasing， making it a prominent research topic in this field. This review summarizes the approaches for establishing and evaluating risk prediction models and discusses potential future challenges and opportunities.

Endoscopic endonasal approach has been widely used for removing various sellae tumors including pituitary adenomas, meningiomas, etc. While, performing these surgeries in such a narrow space with different instruments remains a challenge for surgeons, due to the limited field of view, varying illumination, and occlusion of instruments during the operation. Thus, a proper surgical instrument detection method that can provide classification and location information of the operated surgical instrument is critical for surgeons to understand the surgical scenarios and enhance the safety of the clinical operation. To this end, we propose an anchor-free feature aggregation network (AFA-Net) to improve the detection precision of surgical instruments from the endoscopic operation view field. The proposed method utilizes the improved feature pyramid network (FPN) with the depthwise separable convolution and a weighted feature aggregation module to enhance the feature information of the operated surgical instruments. Based on the anchor-free method, a weighted heatmap aggregation module is used to detect surgical instruments. Experimental studies on a public dataset Cholec80 and an intraoperative dataset from a local hospital are conducted, and the detection performance is assessed by the mean precision (AP) and average recall (AR). From both datasets and comparisons, the proposed method achieves 74.1% AP, 67.0% AR and 73.6% AP, 66.7% AR, respectively, which show significant advantages over five mainstream methods in terms of detection performance.

Monkeypox， a zoonotic disease caused by monkeypox virus， can be transmitted among humans. The etiology and the clinical symptoms of monkeypox are analogous to smallpox. Before 2022， monkeypox was mainly reported in central and west Africa as an endemic. Since May 2022， the outbreak of monkeypox has been reported in many non-endemic countries and regions. Now， the number of new cases of monkeypox is increasing rapidly. The pattern of monkeypox transmission is significantly different from that in previous outbreaks， and many studies have proposed the possible influence of genetic evolution on the virulence and host range of monkeypox virus in the incident. Given its similarity to smallpox， the outbreaks of monkeypox have attracted wide international attention. In order to provide a scientific basis for the formulation of specific measures of prevention and control， we reviewed the characteristics of etiology and epidemiology of monkeypox， and made primary analysis of the global epidemic of monkeypox.

Bisphenol F (BPF), BPS and BPAF are gaining popularity as main substitutes to BPA, but there is no clear evidence that these compounds disrupt glycemic homeostasis in the same way. In this study, four bisphenols were administered to C57BL/6 J mice, and showed that the serum insulin was elevated in the BPA and BPS exposed mice, whereas BPF exposed mice exhibited lower serum insulin and higher blood glucose. BPF decreased oxidized glutathione/reduced glutathione ratio (GSSG/GSH) and N6–methyladenosine (m6A) levels, which was responsible for pancreatic apoptosis in mice. Additionally, the downregulation of Nrf2 and the aberrant regulation of the p53-lncRNA H19 signaling pathway further increased miR-200 family in the BPF-exposed pancreas. The miR-200 family directly suppressed Mettl14 and Xiap by targeting their 3' UTR, leading to islet apoptosis. Antioxidant treatment not only elevated m6A levels and insulin contents but also suppressed the miR-200 family in the pancreas, ultimately improving BPF-induced hyperglycemia. Taken together, miR-200 family could serve as a potential oxidative stress-responsive regulator in the pancreas. And moreover, we demonstrated a novel toxicological mechanism in that BPF disrupted the Keap1-Nrf2 redox system to upregulate miR-141/200b/c which controlled pancreatic insulin production and apoptosis via Mettl14 and Xiap, respectively. As the major surrogates of BPA in various applications, BPF was also diabetogenic, which warrants attention in future research.

Objective To analyze the research status of nursing sensitivity indicators in China, and identify possible problems, so as to provide reference for future related research. Methods bliometric analysis method was used to review the existing literature, and CNKI-CJFD, Wanfang Database and CBMdisc were used as data sources to search the related researches of nursing sensitive indicators, and analyze the publication date, region, author, fund support, journals and keywords. Results A total of 572 valid documents on nursing sensitive indicators were retrieved and published in 149 journals. The number of published documents showed an increasing trend, but the fund papers were low, the degree of interdisciplinary was poor, and the quality of documents needed to be improved. Conclusion The research on nursing sensitive indicators has gradually attracted the attention of researchers, and the research quality, breadth and depth, scientific systematicness and other aspects need to be further studied. (目的 分析我国护理敏感指标的研究现状, 明确可能存在的问题, 为今后相关研究进一步提供参考。方法 应用文献计量学分析方法回顾现有文献, 以中国期刊全文数据库、万方数据库和中国生物医学文献数据库为数据来源, 检索护理敏感指标相关研究的文献, 对文献年代、地区、作者、基金支持、期刊、关键词等方面进行分析。结果 检索获得572篇护理敏感指标有效文献, 发表在149种期刊上, 文献年发表量呈增长趋势, 但基金论文较低, 学科交叉程度欠佳、文献质量有待继续提高。结论 护理敏感指标相关研究逐渐受到研究人员的关注与重视, 在研究质量、广度与深度以及科学系统性等方面有待继续研究。)

To study the distribution characteristics of the overall electromagnetic environment in the main working areas of an underground utility tunnel, a set of process and monitoring methods for the electromagnetic environment layout of the underground utility tunnel was established by referring to relevant standards. The electromagnetic environment of five underground utility tunnels in Xiamen was monitored using the above-mentioned method from 2017 to 2019. The power frequency electric field intensity range is 0.084~4.995 V/m, and the power frequency magnetic induction intensity is 0.026~21.069 μT. The overall electromagnetic environment of the utility tunnels meets the national requirements and is much lower than the specified national limits of electromagnetic radiation exposure (a power frequency electric field strength at 50 Hz frequency is less than 4 000 V/m, and the power frequency magnetic induction strength is less than 100 μT). There is no significant difference between months in the overall electromagnetic environment of utility tunnel. However, in the underground utility tunnel of Jimei Avenue in Xiamen, where 110 kV transmission line is connected and the outer material is slightly damaged, the power frequency electromagnetic field intensity is significantly higher than that of the ordinary monitoring points, and there is no significant difference between the power frequency magnetic induction intensity and the ordinary monitoring points. The electromagnetic environment of underground utility tunnels in Xiamen is safe for employees. Compared with overhead 110 kV transmission lines, it has less impact on the surrounding electromagnetic environment.

Two pyrazol-4-carboxamides, 3-(difluoromethyl)-N-(mesitylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxa-mide (7a) and 3-(difluoromethyl)-N-((3,5-dimethylphenyl) carbamoyl)-1-methyl-1H-pyrazole-4-carboxamide (7b) were synthesized and their structures were confirmed by the aid of 1H NMR and HRMS analyses. The structure of the pyrazole-4-carboxamide, 7a was also determined by X-ray diffraction. The preliminary activity results demonstrate that these two compounds exhibit good inhibitory activity against Botrytis cinerea. Further docking results indicated that the key active group is difluoromethyl pyrazole moiety.

Evaluating reservoirs by pore structure has been widely used in oil and gas development, but this method has not yet been used in the evaluation of potassium salt reservoirs. The pore throat type and structure, capillary pressure curve, and quantitative feature parameters of pore throat of the Paleocene-Cretaceous-rich potassium-rich brine reservoir in Jianghan basin are studied by using a large number of reservoir porosity and pore throat data obtained by Scanning Electron Microscopy and Mercury Intrusion. Combined with the discharge pressure and other experimental parameters, the pore structure is divided into Ⅰ, Ⅱ, and Ⅲ types. The results show that the sandstone reservoirs of the Paleocene Shashi Formation are dominated by type Ⅱ pore structure with the average displacement pressure of 2.72 MPa and the average porosity of 6.32%. The sandstone reservoirs of the Cretaceous Honghuatao Formation are dominated by Ⅰ and Ⅱ pore structure types. The displacement pressure of type Ⅰ is 0.28 MPa, the average porosity is 16.99%, and the permeability is 87.79×10-3 μm2. The average displacement pressure of type Ⅱ is 1.103 MPa, the average porosity is 10.02%, and the permeability is 18.83×10-3 μm2. The quality of the reservoir was evaluated by a comprehensive analysis of pore throat quantitative parameters such as maximum mercury saturation, maximum pore throat radius, median radius and mercury recovery efficiency. It is believed that the sandstone type of the Paleocene Shashi Formation is dominated by siltstone, and the quality of the reservoir is poor, which belongs to the low porosity and low permeability reservoir. The sandstone type of the Cretaceous Honghuatao Formation is mainly fine sandstone, and the reservoir is of good quality and belongs to low porosity and low permeability reservoir. This study provides a reliable geological basis for the evaluation of potassium-rich brine reservoirs and for further exploration and development.

Gantry crane girder structure testing systems can be measured with the deflection of main beam with different structures in the same test environment. At first,through the finite element analysis,the four-pillar tester couldn’t meet the requirements of the large span bending test,Thus,through the finite element simulation,two pillar tester can meet the test requirements,Besides,the use of reinforced concrete structures constitute a closed since the reaction force loading system with the load frame steel structure,instead of the traditional steel structure used in the large span bending test. Finally,compared with the selection of four column structure,the advantages of the two column structure with reinforced concrete structure are given in equipment costs,installation and debugging.