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1. The normal state of attractive Fermi gases from coupled-cluster theory

Author

Callahan, James M., Sous, John, and Berkelbach, Timothy C.

Subjects
Condensed Matter - Quantum Gases, Physics - Atomic Physics, Physics - Chemical Physics
Abstract

We introduce coupled-cluster (CC) theory for the numerical study of the normal state of two-component, dilute Fermi gases with attractive, short-range interactions at zero temperature. We focus on CC theory with double excitations (CCD) and discuss its close relationship with -- and improvement upon -- the t-matrix approximation, i.e., the resummation of ladder diagrams via a random-phase approximation. We further discuss its relationship with Chevy's variational wavefunction ansatz for the Fermi polaron and argue that CCD is its natural extension to nonzero minority species concentrations. Studying normal state energetics for a range of interaction strengths below and above unitarity, we find that CCD yields good agreement with fixed-node diffusion Monte Carlo. We find that CCD does not converge for small polarizations and large interaction strengths, which we speculatively attribute to the nascent instability to a superfluid state., Comment: 7 pages, 3 figures

Published
2022
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3. Dynamical correlation energy of metals in large basis sets from downfolding and composite approaches

Author

Callahan, James M., Lange, Malte F., and Berkelbach, Timothy C.

Subjects
Condensed Matter - Materials Science, Physics - Chemical Physics
Abstract

Coupled-cluster theory with single and double excitations (CCSD) is a promising ab initio method for the electronic structure of three-dimensional metals, for which second-order perturbation theory (MP2) diverges in the thermodynamic limit. However, due to the high cost and poor convergence of CCSD with respect to basis size, applying CCSD to periodic systems often leads to large basis set errors. In a common "composite" method, MP2 is used to recover the missing dynamical correlation energy through a focal-point correction, but the inadequacy of MP2 for metals raises questions about this approach. Here we describe how high-energy excitations treated by MP2 can be "downfolded" into a low-energy active space to be treated by CCSD. Comparing how the composite and downfolding approaches perform for the uniform electron gas, we find that the latter converges more quickly with respect to the basis set size. Nonetheless, the composite approach is surprisingly accurate because it removes the problematic MP2 treatment of double excitations near the Fermi surface. Using the method to estimate the CCSD correlation energy in the combined complete basis set and thermodynamic limits, we find CCSD recovers over 90% of the exact correlation energy at $r_s=4$. We also test the composite and downfolding approaches with the random-phase approximation used in place of MP2, yielding a method that is more effective but more expensive., Comment: 7 pages, 4 figures

Published
2021
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4. Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement

Author

Barton, Linda S., Callahan, James F., Cantizani, Juan, Concha, Nestor O., Cotillo Torrejon, Ignacio, Goodwin, Nicole C., Joshi-Pangu, Amruta, Kiesow, Terry J., McAtee, Jeff J., Mellinger, Mark, Nixon, Christopher J., Padrón-Barthe, Laura, Patterson, Jaclyn R., Pearson, Neil D., Pouliot, Jeffrey J., Rendina, Alan R., Buitrago Santanilla, Alexander, Schneck, Jessica L., Sanz, Olalla, Thalji, Reema K., Ward, Paris, Williams, Shawn P., and King, Bryan W.

Published
2024
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5. Pediatric Readiness in Emergency Medical Services Systems

Author

Moore, Brian, Shah, Manish I, Owusu-Ansah, Sylvia, Gross, Toni, Brown, Kathleen, Gausche-Hill, Marianne, Remick, Katherine, Adelgais, Kathleen, Lyng, John, Rappaport, Lara, Snow, Sally, Wright-Johnson, Cynthia, Leonard, Julie C, ACADEMY OF PEDIATRICS, Committee on Pediatric Emergency Medicine and Section on Emergency Medicine EMS Subcommittee AMERICAN, Wright, Joseph, Adirim, Terry, Agus, Michael SD, Callahan, James, Lane, Natalie, Lee, Lois, Mazor, Suzan, Mahajan, Prashant, Timm, Nathan, PHYSICIANS, Emergency Medical Services Committee AMERICAN COLLEGE OF EMERGENCY, Goodloe, Jeffrey, Abell, Becky, Alson, Roy, Bachista, Kerry, Bowman, Lynthia, Boynton, Heather, Brown, Sara Ann, Chang, Allen, Copeland, Darby, De Lorenzo, Robert, Douglas, Derek, Fowler, Raymond, Gallagher, John, Gilliam, Sheaffer, Guyette, Frank, Holland, Dustin, Jarvis, Jeffrey, Kalan, Clinton, Keeperman, Jacob, Kupas, Douglas, Lairet, Julio, Levy, Michael, Lyon, Kristopher, Manifold, Craig, McCabe-Kline, Kristin, Mell, Howard, Miller, Brian, Millin, Michael, Rosen, Brett, Ross, Jared, Ryan, Kevin, Sanko, Stephen, Schlesinger, Shira, Sheppard, Charles, Sibold, Harry, Smith, Sullivan, Spigner, Michael, Stracuzzi, Vincent, Tanski, Christopher, Tennyson, Joseph, White, Chelsea, Wilcocks, David, Yee, Allen, ASSOCIATION, Pediatric Committee EMERGENCY NURSES, Young, Tiffany, Foresman-Capuzzi, Joyce, Johnson, Rose, Martin, Heather, Milici, Justin, Brandt, Cam, Nelson, Nicholas, PHYSICIANS, Standards and Clinical Practice Committee NATIONAL ASSOCIATION OF EMERGENCY MEDICAL SERVICES, TECHNICIANS, Emergency Pediatric Care Committee NATIONAL ASSOCIATION OF EMERGENCY MEDICAL, Watson, Shannon, Dietrich, Ann, Bates, Kyle, Flake, Frank, Flores, Gustavo, Systems, Pediatric Readiness in Emergency Medical Services, STATEMENT, POLICY, and Children, Organizational Principles to Guide and Define the Child Health Care System and or Improve the Health of All

Subjects
Child, Emergencies, Emergency Medical Services, Humans, Pediatric Emergency Medicine, AMERICAN ACADEMY OF PEDIATRICS, Committee on Pediatric Emergency Medicine and Section on Emergency Medicine EMS Subcommittee, AMERICAN COLLEGE OF EMERGENCY PHYSICIANS, Emergency Medical Services Committee, EMERGENCY NURSES ASSOCIATION, Pediatric Committee, NATIONAL ASSOCIATION OF EMERGENCY MEDICAL SERVICES PHYSICIANS, Standards and Clinical Practice Committee, NATIONAL ASSOCIATION OF EMERGENCY MEDICAL TECHNICIANS, Emergency Pediatric Care Committee, Pediatric Readiness in Emergency Medical Services Systems, POLICY STATEMENT, Organizational Principles to Guide and Define the Child Health Care System and/or Improve the Health of All Children, Clinical Sciences, Emergency & Critical Care Medicine
Published
2020

6. Drugs Used to Treat Pediatric Emergencies

Author

Shenoi, Rohit P, Timm, Nathan, Jones, Bridgette, Neville, Kathleen, Foster, Jennifer, Houck, Connie, Laughon, Matthew, Paul, Ian, Reigart, Routt J, Sullivan, Janice, van den Anker, John, Wright, Joseph, Adirim, Terry, Callahan, James, Agus, Michael, Gonzalez del Rey, Javier, Gross, Toni, Joseph, Madeline, Lane, Natalie, Lee, Lois, Mack, Elizabeth, Mahajan, Prashant, Marin, Jennifer, and Mazor, Suzan

Subjects
Emergency Care, Heart Disease, Pediatric, Cardiovascular, Child, Drug Therapy, Emergencies, Emergency Medical Services, Emergency Service, Hospital, Humans, Pediatrics, COMMITTEE ON DRUGS, COMMITTEE ON PEDIATRIC EMERGENCY MEDICINE, Medical and Health Sciences, Psychology and Cognitive Sciences
Abstract

This clinical report is a revision of "Preparing for Pediatric Emergencies: Drugs to Consider." It updates the list, indications, and dosages of medications used to treat pediatric emergencies in the prehospital, pediatric clinic, and emergency department settings. Although it is not an all-inclusive list of medications that may be used in all emergencies, this resource will be helpful when treating a vast majority of pediatric medical emergencies. Dosage recommendations are consistent with current emergency references such as the Advanced Pediatric Life Support and Pediatric Advanced Life Support textbooks and American Heart Association resuscitation guidelines.

Published
2020

7. Access to Critical Health Information for Children During Emergencies: Emergency Information Forms and Beyond

Author

Dietrich, Ann M., Chairperson, Alade, Kiyetta H., Amato, Christopher S., Atanelov, Zaza, Auerbach, Marc, Barata, Isabel A., Benjamin, Lee S., Berg, Kathleen T., Brown, Kathleen, Chang, Cindy, Chow, Jessica, Chumpitazi, Corrie E., Claudius, Ilene A., Easter, Joshua, Foster, Ashley, Fox, Sean M., Gausche-Hill, Marianne, Gerardi, Michael J., Goodloe, Jeffrey M., Heniff, Melanie, Homme, James (Jim) L., Ishimine, Paul T., John, Susan D., Joseph, Madeline M., Lam, Samuel Hiu-Fung, Lawson, Simone L., Lee, Moon O., Li, Joyce, Lin, Sophia D., Martini, Dyllon Ivy, Mellick, Larry Bruce, Mendez, Donna, Petrack, Emory M., Rice, Lauren, Rose, Emily A., Ruttan, Timothy, Saidinejad, Mohsen, Santillanes, Genevieve, Simpson, Joelle N., Sivasankar, Shyam M., Slubowski, Daniel, Sorrentino, Annalise, Stoner, Michael J., Sulton, Carmen D., Valente, Jonathan H., Vora, Samreen, Wall, Jessica J., Wallin, Dina, Walls, Theresa A., Waseem, Muhammad, Woolridge, Dale P., Callahan, James M., Baldwin, Steve, Bodnar, Chelsea, Fuchs, Susan, Krug, Steven, Lightfoot, Cynthiana, Raskas, Mordechai, and Weinberg, Stuart

Published
2023
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8. Pediatric Readiness in the Emergency Department

Author

Remick, Katherine, Gausche-Hill, Marianne, Joseph, Madeline M, Brown, Kathleen, Snow, Sally K, Wright, Joseph L, AMERICAN ACADEMY OF PEDIATRICS, Committee on Pediatric Emergency Medicine, Wright, Joseph, Adirim, Terry, Agus, Michael SD, Callahan, James, Gross, Toni, Lane, Natalie, Lee, Lois, Mazor, Suzan, Mahajan, Prashant, Timm, Nathan, PHYSICIANS, Pediatric Emergency Medicine Committee AMERICAN COLLEGE OF EMERGENCY, Alade, Kiyetta, Amato, Christopher, Avarello, Jahn T, Baldwin, Steven, Barata, Isabel A, Benjamin, Lee S, Berg, Kathleen, Bullard-Berent, Jeffrey, Dietrich, Ann Marie, Friesen, Phillip, Gerardi, Michael, Heins, Alan, Holtzman, Doug K, Homme, Jeffrey, Horeczko, Timothy, Ishimine, Paul, Lam, Samuel, Long, Katharine, Mayz, Kurtis, Mehta, Sanjay, Mellick, Larry, Ojo, Aderonke, Paul, Audrey Z, Pauze, Denis R, Pearson, Nadia M, Perina, Debra, Petrack, Emory, Rayburn, David, Rose, Emily, Russell, W Scott, Ruttan, Timothy, Saidinejad, Mohsen, Sanders, Brian, Simpson, Joelle, Solari, Patrick, Stoner, Michael, Valente, Jonathan H, Wall, Jessica, Wallin, Dina, Waseem, Muhammad, Whiteman, Paula J, Woolridge, Dale, ASSOCIATION, Pediatric Committee EMERGENCY NURSES, Young, Tiffany, Foresman-Capuzzi, Joyce, Johnson, Rose, Martin, Heather, Milici, Justin, Brandt, Cam, Nelson, Nicholas, Department, Pediatric Readiness in the Emergency, STATEMENT, POLICY, and Children, Organizational Principles to Guide and Define the Child Health Care System and or Improve the Health of All

Subjects
Child, Emergency Medical Services, Emergency Service, Hospital, Emergency Treatment, Evidence-Based Emergency Medicine, Humans, Organizational Policy, Pediatrics, Practice Guidelines as Topic, Quality Improvement, Quality Indicators, Health Care, United States, AMERICAN ACADEMY OF PEDIATRICS, Committee on Pediatric Emergency Medicine, Section on Surgery, AMERICAN COLLEGE OF EMERGENCY PHYSICIANS, Pediatric Emergency Medicine Committee, EMERGENCY NURSES ASSOCIATION, Pediatric Committee, Pediatric Readiness in the Emergency Department, POLICY STATEMENT, Organizational Principles to Guide and Define the Child Health Care System and/or Improve the Health of All Children, Clinical Sciences, Emergency & Critical Care Medicine
Published
2018

9. Early Recurrence of First Unprovoked Seizures in Children

Author

Goldberg, Leah R, Kernie, Catherine G, Lillis, Kathleen, Bennett, Jonathan, Conners, Gregory, Macias, Charles G, Callahan, James, Akman, Cigdem, Hauser, W Allen, Kuppermann, Nathan, and Dayan, Peter S

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurodegenerative, Pediatric, Neurosciences, Epilepsy, Brain Disorders, Clinical Research, Adolescent, Age Factors, Anticonvulsants, Child, Child, Preschool, Cohort Studies, Electroencephalography, Female, Humans, Infant, Male, Odds Ratio, Recurrence, Risk Factors, Seizures, Time Factors, Public Health and Health Services, Emergency & Critical Care Medicine, Clinical sciences
Abstract

ObjectivesThe risk of early seizure recurrences after first unprovoked seizures in children is largely unknown. We aimed to determine the rate of seizure recurrence within 14 days of first unprovoked seizures in children and identify associated risk factors. Secondarily, we aimed to determine the risk of recurrence at 48 hours and 4 months.MethodsWe conducted a secondary analysis of a multicenter cohort study of children 29 days to 18 years with first unprovoked seizures. Emergency department (ED) clinicians completed standardized histories and physical examinations. The primary outcome, recurrent seizure at 14 days, and the secondary outcomes, recurrence at 48 hours and 4 months, were assessed by telephone follow-up and medical record review. For each recurrence time point, we excluded those patients for whom no seizure had recurred but chronic antiepileptic drugs had been initiated.ResultsA total of 475 patients were enrolled in the parent study. Of evaluable patients for this secondary analysis, 26 of 392 (6.6%, 95% confidence interval [CI] = 4.4%-9.6%) had recurrences within 48 hours of the incident seizures, 58 of 366 (15.8%, 95% CI = 12.3%-20.0%) had recurrences within 14 days, and 107 of 340 (31.5%, 95% CI = 26.6%-36.7%) had recurrences within 4 months. On logistic regression analysis, age younger than 3 years was independently associated with a higher risk of 14-day recurrence (adjusted odds ratio [OR] = 2.1, 95% CI = 1.2-3.7; p = 0.01). Having had more than one seizure within the 24 hours prior to ED presentation was independently associated with a higher risk of seizure recurrence at 48 hours (adjusted OR = 4.3, 95% CI = 1.9-9.8; p

Published
2018

10. Pediatric Medication Safety in the Emergency Department

Author

Benjamin, Lee, Frush, Karen, Shaw, Kathy, Shook, Joan E, Snow, Sally K, ACADEMY OF PEDIATRICS, Committee on Pediatric Emergency Medicine AMERICAN, Wright, Joseph, Adirim, Terry, Agus, Michael SD, Callahan, James, Gross, Toni, Lane, Natalie, Lee, Lois, Mazor, Suzan, Mahajan, Prashant, Timm, Nathan, PHYSICIANS, Pediatric Emergency Medicine Committee AMERICAN COLLEGE OF EMERGENCY, Joseph, Madeline, Alade, Kiyetta, Amato, Christopher, Avarello, Jahn T, Baldwin, Steven, Barata, Isabel A, Benjamin, Lee S, Berg, Kathleen, Brown, Kathleen, Bullard-Berent, Jeffrey, Dietrich, Ann M, Friesen, Phillip, Gerardi, Michael, Heins, Alan, Holtzman, Doug K, Homme, Jeffrey, Horeczko, Timothy, Ishimine, Paul, Lam, Samuel, Long, Katharine, Mayz, Kurtis, Mehta, Sanjay, Mellick, Larry, Ojo, Aderonke, Paul, Audrey Z, Pauze, Denis R, Pearson, Nadia M, Perina, Debra, Petrack, Emory, Rayburn, David, Rose, Emily, Russell, W Scott, Ruttan, Timothy, Saidinejad, Mohsen, Sanders, Brian, Simpson, Joelle, Solari, Patrick, Stoner, Michael, Valente, Jonathan H, Wall, Jessica, Wallin, Dina, Waseem, Muhammad, Whiteman, Paula J, Woolridge, Dale, ASSOCIATION, Pediatric Emergency Medicine Committee EMERGENCY NURSES, Young, Tiffany, Foresman-Capuzzi, Joyce, Johnson, Rose, Martin, Heather, Milici, Justin, Brandt, Cam, Nelson, Nicholas, Statement, Policy, and Children, Organizational Principles to Guide and Define the Child Health Care System and Improve the Health of All

Subjects
Child, Emergency Service, Hospital, Humans, Medication Errors, Patient Safety, Risk Factors, AMERICAN ACADEMY OF PEDIATRICS, Committee on Pediatric Emergency Medicine, AMERICAN COLLEGE OF EMERGENCY PHYSICIANS, Pediatric Emergency Medicine Committee, EMERGENCY NURSES ASSOCIATION, Pediatric Emergency Medicine Committee, Policy Statement, Organizational Principles to Guide and Define the Child Health Care System and Improve the Health of All Children, Clinical Sciences, Emergency & Critical Care Medicine
Published
2018

11. Implementation of point-of-care molecular testing for respiratory viruses in congregate living settings

Author

Tan, Charlie, primary, Chan, Christina K., additional, Ofner, Marianna, additional, O’Brien, Jaclyn, additional, Thomas, Neethu R., additional, Callahan, James, additional, Pascual, Brigitte, additional, Palmer, Shawn J., additional, Serapion, Victoria, additional, Fabro, Hannah, additional, Kozak, Robert A., additional, Candon, Heather, additional, Chan, Adrienne K., additional, Powis, Jeff E., additional, and Leis, Jerome A., additional

Published
2024
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12. Predictors of SARS-CoV-2 transmission in congregate living settings: a multicenter prospective study

Author

Leis, Jerome A., primary, Chan, Christina K., additional, Tan, Charlie, additional, Callahan, James, additional, Serapion, Victoria, additional, Pascual, Brigitte, additional, Lee, Wayne, additional, O’Brien, Jaclyn, additional, Thomas, Neethu R., additional, Candon, Heather, additional, Crittenden, Matthew, additional, Kiss, Alex, additional, Chan, Adrienne K, additional, Ofner, Marianna, additional, and Powis, Jeff E., additional

Published
2024
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13. Prevalence of and Risk Factors for Intracranial Abnormalities in Unprovoked Seizures

Author

Dayan, Peter S, Lillis, Kathleen, Bennett, Jonathan, Conners, Gregory, Bailey, Pam, Callahan, James, Akman, Cigdem, Feldstein, Neil, Kriger, Joshua, Hauser, W Allen, and Kuppermann, Nathan

Subjects
Neurodegenerative, Pediatric, Biomedical Imaging, Clinical Research, Brain Disorders, Neurosciences, Epilepsy, Adolescent, Brain, Child, Child, Preschool, Congenital Abnormalities, Female, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Neuroimaging, Prevalence, Prospective Studies, Risk Factors, Seizures, Tomography, X-Ray Computed, Medical and Health Sciences, Psychology and Cognitive Sciences, Pediatrics
Abstract

Background and objectivesProspective data are lacking to determine which children might benefit from prompt neuroimaging after unprovoked seizures. We aimed to determine the prevalence of, and risk factors for, relevant intracranial abnormalities in children with first, unprovoked seizures.MethodsWe conducted a 6-center prospective study in children aged >28 days to 18 years with seemingly unprovoked seizures. Emergency department (ED) clinicians documented clinical findings on a standardized form. Our main outcome was the presence of a clinically relevant intracranial abnormality on computed tomography (CT) or MRI, defined as those that might change management, either emergently, urgently, or nonurgently.ResultsWe enrolled 475 of 625 (76%) eligible patients. Of 354 patients for whom cranial MRI or CT scans were obtained in the ED or within 4 months of the ED visit, 40 (11.3%; 95% confidence interval [CI]: 8.0-14.6%) had clinically relevant intracranial abnormalities, with 3 (0.8%; 95% CI: 0.1-1.8%) having emergent/urgent abnormalities. On logistic regression analysis, a high-risk past medical history (adjusted odds ratio: 9.2; 95% CI: 2.4-35.7) and any focal aspect to the seizure (odds ratio: 2.5; 95% CI: 1.2-5.3) were independently associated with clinically relevant abnormalities.ConclusionsClinically relevant intracranial abnormalities occur in 11% of children with first, unprovoked seizures. Emergent/urgent abnormalities, however, occur in

Published
2015

14. Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo

Author

Boehm, Jeffrey, Davis, Roderick, Murar, Claudia E., Li, Tindy, McCleland, Brent, Dong, Shuping, Yan, Hongxing, Kerns, Jeffrey, Moody, Christopher J., Wilson, Anthony J., Graves, Alan P., Mentzer, Mary, Qi, Hongwei, Yonchuk, John, Kou, Jen-Pyng, Foley, Joseph, Sanchez, Yolanda, Podolin, Patricia L., Bolognese, Brian, Booth-Genthe, Catherine, Galop, Marc, Wolfe, Lawrence, Carr, Robin, and Callahan, James F.

Published
2019
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15. Pediatric Readiness in the Emergency Department

Author

Wright, Joseph, Adirim, Terry, Agus, Michael S.D., Callahan, James, Gross, Toni, Lane, Natalie, Lee, Lois, Mazor, Suzan, Mahajan, Prashant, Timm, Nathan, Joseph, Madeline M., Alade, Kiyetta, Amato, Christopher, Avarello, Jahn T., Baldwin, Steven, Barata, Isabel A., Benjamin, Lee S., Berg, Kathleen, Brown, Kathleen, Bullard-Berent, Jeffrey, Dietrich, Ann Marie, Friesen, Phillip, Gerardi, Michael, Heins, Alan, Holtzman, Doug K., Homme, Jeffrey, Horeczko, Timothy, Ishimine, Paul, Lam, Samuel, Long, Katharine, Mayz, Kurtis, Mehta, Sanjay, Mellick, Larry, Ojo, Aderonke, Paul, Audrey Z., Pauze, Denis R., Pearson, Nadia M., Perina, Debra, Petrack, Emory, Rayburn, David, Rose, Emily, Russell, W. Scott, Ruttan, Timothy, Saidinejad, Mohsen, Sanders, Brian, Simpson, Joelle, Solari, Patrick, Stoner, Michael, Valente, Jonathan H., Wall, Jessica, Wallin, Dina, Waseem, Muhammad, Whiteman, Paula J., Woolridge, Dale, Young, Tiffany, Foresman-Capuzzi, Joyce, Johnson, Rose, Martin, Heather, Milici, Justin, Brandt, Cam, Nelson, Nicholas, Remick, Katherine, Gausche-Hill, Marianne, Snow, Sally K., and Wright, Joseph L.

Published
2019
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18. A Second Chance for the Fourth Chance: A Critique of the Workforce Investment Act of 1998 and a Challenge to State and Local Workforce Investment Boards. Policy Issues Monograph.

Author

Johns Hopkins Univ., Baltimore, MD. Sar Levitan Center for Social Policy Studies., Mangum, Garth, Mangum, Stephen, Sum, Andrew, Callahan, James, Fogg, Neal, Mangum, Garth, Mangum, Stephen, Sum, Andrew, Callahan, James, Fogg, Neal, and Johns Hopkins Univ., Baltimore, MD. Sar Levitan Center for Social Policy Studies.

Abstract

The effectiveness of the Workforce Investment Act (WIA) of 1998 was critiqued. WIA was praised for providing an avenue for communication among state and local agencies during development of workforce development plans, potentially allowing individuals to choose from a wider array of services and service providers, spreading the concept of one-stop career centers nationwide, and potentially providing for sharper and more meaningful focus on local outcomes. The following shortcomings of WIA were identified: (1) its "work first" commitment makes training a last resort; (2) it lacks a coherent mission; (3) it fails to provide additional monies for improved labor market information systems; and (4) its youth component limits services to the economically disadvantaged. Fifteen specific recommendations for addressing these weaknesses were presented, including the following: (1) allow training operators to serve all dislocated and disadvantaged workers otherwise unable to qualify for and obtain jobs providing family-sustaining earnings; (2) encourage states to launch their own independent workforce development crusades, utilizing federal programs as resources consistent with state objectives; and (3) make federal poverty guidelines consistent with current standards of living, national mores, and variations in the cost of living across states and local areas. (Nineteen tables and 18 references are included.) (MN)

Published
1999

19. The Management of Children and Youth With Pediatric Mental and Behavioral Health Emergencies

Author

Saidinejad, Mohsen, primary, Duffy, Susan, additional, Wallin, Dina, additional, Hoffmann, Jennifer A., additional, Joseph, Madeline, additional, Schieferle Uhlenbrock, Jennifer, additional, Brown, Kathleen, additional, Waseem, Muhammad, additional, Snow, Sally K., additional, Andrew, Madeline, additional, Kuo, Alice A., additional, Sulton, Carmen, additional, Chun, Thomas, additional, Lee, Lois K., additional, Conners, Gregory P., additional, Callahan, James, additional, Gross, Toni, additional, Lee, Lois, additional, Mack, Elizabeth, additional, Marin, Jennifer, additional, Mazor, Suzan, additional, Paul, Ronald, additional, Timm, Nathan, additional, Dietrich, Ann M., additional, Alade, Kiyetta H., additional, Amato, Christopher S., additional, Atanelov, Zaza, additional, Auerbach, Marc, additional, Barata, Isabel A., additional, Benjamin, Lee S., additional, Berg, Kathleen T., additional, Chang, Cindy, additional, Chow, Jessica, additional, Chumpitazi, Corrie E., additional, Claudius, Ilene A., additional, Easter, Joshua, additional, Foster, Ashley, additional, Fox, Sean M., additional, Gausche-Hill, Marianne, additional, Gerardi, Michael J., additional, Goodloe, Jeffrey M., additional, Heniff, Melanie, additional, Homme, James (Jim) L., additional, Ishimine, Paul T., additional, John, Susan D., additional, Joseph, Madeline M., additional, Lam, Samuel Hiu-Fung, additional, Lawson, Simone L., additional, Lee, Moon O., additional, Li, Joyce, additional, Lin, Sophia D., additional, Martini, Dyllon Ivy, additional, Mellick, Larry Bruce, additional, Mendez, Donna, additional, Petrack, Emory M., additional, Rice, Lauren, additional, Rose, Emily A., additional, Ruttan, Timothy, additional, Saidinejad, Mohsen, additional, Santillanes, Genevieve, additional, Simpson, Joelle N., additional, Sivasankar, Shyam M., additional, Slubowski, Daniel, additional, Sorrentino, Annalise, additional, Stoner, Michael J., additional, Sulton, Carmen D., additional, Valente, Jonathan H., additional, Vora, Samreen, additional, Wall, Jessica J., additional, Walls, Theresa A., additional, Woolridge, Dale P., additional, Brandt, Cam, additional, Kult, Krisi M., additional, Milici, Justin J., additional, Nelson, Nicholas A., additional, Redlo, Michele A., additional, Curtis Cooper, Maureen R., additional, Redlo, Michele, additional, Kult, Krisi, additional, Logee, Katherine, additional, Bryant, Dixie Elizabeth, additional, Cooper, Maureen Curtis, additional, and Cline, Kristen, additional

Published
2023
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20. ANTEBELLUM ENIGMA: JUSTICE WOODBURY DAVIS, THE MAINE SUPREME JUDICIAL COURT, AND THE ANTISLAVERY CONSTITUTION.

Author

CALLAHAN, JAMES

Subjects
*SLAVERY, *ACTIVISTS, *SUFFRAGE, *CIVIL rights
Abstract

In 1856, abolition activist Woodbury Davis joined the Maine Supreme Judicial Court (SJC) and quickly became its most radical member. Davis was an antebellum enigma: a high-ranking judge who advocated for Black voting rights, rejected the federal consensus that Congress could not pass laws interfering with slavery, denied that the Fugitive Slave Clause even applied to slaves, and believed that the Constitution was an engine for abolition. While Davis was on the SJC, the court issued advisory opinions on two of the most explosive issues in American politics: Black voting rights after Dred Scott v. Sandford and the Fugitive Slave Act. This Note explores the evolution of the law on slavery and race in the United States prior to the Civil War, focusing on Maine and the political pressures surrounding the SJC at that time. Next, this Note examines the SJC’s Voting Rights Opinion (1857) and the Personal Liberty Law Opinion (1861), focusing especially on Justice Davis’s novel constitutional arguments. Finally, drawing on these two cases, this Note argues that radical modes of antislavery constitutionalism were embedded in the American judiciary prior to the Civil War and evaluates the impact of this discovery on current debates in legal history. [ABSTRACT FROM AUTHOR]

Published
2024

23. Calculus in Context

Author

Callahan, James, author, Cox, David, author, and Hoffman, Kenneth, author

Subjects
Mathematics, Calculus, Textbooks
Abstract

Designing the curriculum We believe that calculus can be for students what it was for Euler and the Bernoullis: a language and a tool for exploring the whole fabric of science. We also believe that much of the mathematical depth and vitality of calculus lies in connections to other sciences. The mathematical questions that arise are compelling in part because the answers matter to other disciplines. We began our work with a "clean slate," not by asking what parts of the traditional course to include or discard. Our starting points are thus our summary of what calculus is really about. Our curricular goals are what we aim to convey about the subject in the course. Our functional goals describe the attitudes and behaviors we hope our students will adopt in using calculus to approach scientific and mathematical questions. Starting Points Calculus is fundamentally a way of dealing with functional relationships that occur in scientific and mathematical contexts. The techniques of calculus must be subordinate to an overall view of the questions that give rise to these relationships. Technology radically enlarges the range of questions we can explore and the ways we can answer them. Computers and graphing calculators are much more than tools for teaching the traditional calculus. The concept of a dynamical system is central to science. Therefore, differential equations belong at the center of calculus, and technology makes this possible at the introductory level. The process of successive approximation is a key tool of calculus, even when the outcome of the process--the limit--cannot be explicitly given in closed form. Curricular Goals Develop calculus in the context of scientific and mathematical questions. Treat systems of differential equations as fundamental objects of study. Construct and analyze mathematical models. Use the method of successive approximations to define and solve problems. Develop geometric visualization with hand-drawn and computer graphics. Give numerical methods a more central role. Functional Goals Encourage collaborative work. Enable students to use calculus as a language and a tool. Make students comfortable tackling large, messy, ill-defined problems. Foster an experimental attitude towards mathematics. Help students appreciate the value of approximate solutions. Teach students that understanding grows out of working on problems. Impact of Technology Differential equations can now be solved numerically, so they can take their rightful place in the introductory calculus course. The ability to handle data and perform many computations makes exploring messy, real-world problems possible. Since we can now deal with credible models, the role of modelling becomes much more central to the subject. The text illustrates how we have pursued the curricular goals. Each goal is addressed within the first chapter which begins with questions about describing and analyzing the spread of a contagious disease. A model is built: a model which is actually a system of coupled non-linear differential equations. We then begin a numerical exploration on those equations, and the door is opened to a solution by successive approximations. Our implementation of the functional goals is also evident. The text has many more words than the traditional calculus book--it is a book to be read. The exercises make unusual demands on students. Most are not just variants of examples that have been worked in the text. In fact, the text has rather few "template'' examples. Shifts in Emphasis It will also become apparent to you that the text reflects substantial shifts in emphasis in comparison to the traditional course. Here are some of the most striking: How the emphasis shifts: increase: concepts, geometry, graphs, brute force, numerical solutions decrease: techniques, algebra, formulas, elegance, closed-form solutions Since we all value elegance, let us explain what we mean by "brute force." Euler's method is a good example. It is a general method of wide applicability. Of course when we use it to solve a differential equation like y'(t) = t, we are using a sledgehammer to crack a peanut. But at least the sledgehammer works. Moreover, it works with coconuts (like y' = y(1 - y/10)), and it will even knock down a house (like y' = cos2(t)). Students also see the elegant special methods that can be invoked to solve y' = t and y' = y(1 - y/10) (separation of variables and partial fractions are discussed in chapter 11), but they understand that they are fortunate indeed when a real problem will succumb to such methods.

Published
1994

25. NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease

Author

Ryan, Eilise M., primary, Sadiku, Pranvera, additional, Coelho, Patricia, additional, Watts, Emily R., additional, Zhang, Ailiang, additional, Howden, Andrew J. M., additional, Sanchez-Garcia, Manuel A., additional, Bewley, Martin, additional, Cole, Joby, additional, McHugh, Brian J., additional, Vermaelen, Wesley, additional, Ghesquiere, Bart, additional, Carmeliet, Peter, additional, Rodriguez Blanco, Giovanny, additional, Von Kriegsheim, Alex, additional, Sanchez, Yolanda, additional, Rumsey, William, additional, Callahan, James F., additional, Cooper, George, additional, Parkinson, Nicholas, additional, Baillie, Kenneth, additional, Cantrell, Doreen A., additional, McCafferty, John, additional, Choudhury, Gourab, additional, Singh, Dave, additional, Dockrell, David H., additional, Whyte, Moira K. B., additional, and Walmsley, Sarah R., additional

Published
2023
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38. Artificial Intelligence in Nursing Education: Opportunities and Challenges.

Author

Glauberman, Gary, Ito-Fujita, Avree, Katz, Shayna, and Callahan, James

Subjects
ARTIFICIAL intelligence, NURSING education, SIMULATED patients, CATHETER-associated urinary tract infections, NATURAL language processing, CLINICAL decision support systems, NURSING literature, PATIENT-centered medical homes
Abstract

The article explores the impact of Artificial Intelligence (AI) on nursing education, discussing its potential benefits in healthcare, the transformation of nursing care through AI, and providing guidance for nursing professionals and educators. The piece also outlines opportunities, such as AI-enriched simulation for personalized learning and enhanced clinical judgment tools, as well as challenges, including concerns about overreliance on technology, AI algorithm bias, and security issue.

Published
2023

40. Exploration of the P1 Residue in CL Protease Inhibitors Leading to the Discovery of a Novel 2-Tetrahydrofuran P1 Replacement

Author

Barton, Linda, primary, Callahan, James F., additional, Cantizani, Juan, additional, Concha, Nestor O., additional, Torrejon, Ignacio Cotillo, additional, Goodwin, Nicole C., additional, Joshi-Pangu, Amruta, additional, Kiesow, Terry J., additional, McAtee, Jeff J., additional, Mellinger, Mark, additional, Nixon, Christopher J., additional, Padrón, Laura, additional, Patterson, Jaclyn R., additional, Pearson, Neil D., additional, Pouliot, Jeffrey J., additional, Rendina, Alan R., additional, Santanilla, Alexander Buitrago, additional, Schneck, Jessica L., additional, Sanz, Olalla, additional, Thalji, Reema K., additional, Ward, Paris, additional, Williams, Shawn P., additional, and King, Bryan W., additional

Published
2023
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41. NRF2 activation reprogrammes defects in oxidative metabolism to restore macrophage function in COPD

Author

Ryan, Eilise, Sadiku, Pranvera, Coelho, Patricia, Watts, Emily R, Zhang, Ailiang, Howden, Andrew J M, Sanchez Garcia, Manuel Alejandro, Bewley, Martin A., Cole, Joby, McHugh, Brian, Vermaelen, Wesley, Ghesquiere, Bart, Carmeliet, Peter, Rodriguez Blanco, Giovanny, von Kriegsheim, Alexander, Sanchez, Yolanda, Rumsey, William, Callahan, James F, Cooper, George, Parkinson, Nicholas, Baillie, J Kenneth, Cantrell, Doreen, McCafferty, John, Choudhury, Gourab, Singh, David, Dockrell, David H, Whyte, Moira K B, and Walmsley, Sarah R

Abstract

Rationale: COPD (Chronic Obstructive Pulmonary Disease) is a disease characterized by persistent airway inflammation and disordered macrophage function. The extent to which alterations in macrophage bioenergetics contribute to impaired antioxidant responses and disease pathogenesis has yet to be fully delineated. Objectives: Through the study of COPD alveolar (AM) and peripheral monocyte-derived (MDM) macrophages, we sought to establish if intrinsic defects in core metabolic processes drive macrophage dysfunction and redox imbalance. Methods: AM and MDM from COPD and healthy donors underwent functional, metabolic and transcriptional profiling. Results: We observe that AM and MDM from COPD donors display a critical depletion in glycolytic and mitochondrial respiration derived energy reserves and an over reliance on glycolysis as a source for ATP, resulting in reduced energy status. Defects in oxidative metabolism extend to an impaired redox balance associated with defective expression of the NADPH generating enzyme, malic enzyme 1, a known target of the anti-oxidant transcription factor NRF2. Consequently, selective activation of NRF2 resets the COPD transcriptome, resulting in increased generation of TCA cycle intermediaries, improved energetic status, favorable redox balance and a recovery of macrophage function. Conclusion: In COPD an inherent loss of metabolic plasticity leads to metabolic exhaustion and reduced redox capacity which can be rescued by activation of the NRF2 pathway. Targeting these defects, via NRF2 augmentation, may therefore present an attractive therapeutic strategy for the treatment of the aberrant airway inflammation described in COPD.

Published
2023
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42. Consequences

Author

Callahan, James J., Axler, S., editor, Gehring, F. W., editor, Ribet, K. A., editor, and Callahan, James J.

Published
2000
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43. Intrinsic Geometry

Author

Callahan, James J., Axler, S., editor, Gehring, F. W., editor, Ribet, K. A., editor, and Callahan, James J.

Published
2000
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44. General Relativity

Author

Callahan, James J., Axler, S., editor, Gehring, F. W., editor, Ribet, K. A., editor, and Callahan, James J.

Published
2000
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47. Arbitrary Frames

Author

Callahan, James J., Axler, S., editor, Gehring, F. W., editor, Ribet, K. A., editor, and Callahan, James J.

Published
2000
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49. Contributors

Author

Anderson, Beverly, Arnold, Linda D., Attia, Magdy W., Avner, Jeffrey R., Bajaj, Lalit, Baker, M. Douglas, Baum, Carl R., Bender, Brenda J., Bergamo, David, Brenkert, Timothy, Callahan, James M., Caperell, Kerry S., Carron, Hannah, Chung, Sarita, Cronan, Kate M., Del Pizzo, Jeannine, DePiero, Andrew D., Devens, Monique, Diaz, Maria Carmen G., DiGirolamo, Sara, Doctor, Kaynan, Dudley, Nanette C., Duffy, Susan J., Durani, Yamini, Florin, Todd A., Friedlaender, Eron Y., Friedman, Marla, Fuchs, Susan, Gala, Payal K., Giordano, Katie, Giovanni, Joan Elizabeth, Glissmeyer, Eric W., Hammett, Deborah L., Handa, Arun, Hart, Rebecca J., Hodge, Dee, Hsiao, Allen L., Ishimine, Paul, Johnson, Laurie H., Joshi, Priyanka, Kadish, Howard, Kahane, Caroline G., Kelly, Susan M., Kennedy, Thomas M., Kieffer, Jody C., Kim, Jenny, Kusulas, Matthew P., Lavoie, Megan, Loiselle, John M., Lorch, Margarita S., Ludwig, Stephen, Malburg, Louise, Marchese, Ronald F., Mascarenas, Danielle N., McAneney, Constance M., McNickle, Lauren, Meghpara, Meghan, Mercurio, Laura, Nadel, Frances M., Nelson, Courtney E., Olympia, Robert P., Osterhoudt, Kevin C., Park, Brian L., Pifko, Elysha, Popovsky, Erica Y., Posner, Jill C., Prater, Samuel J., Prince, William B., Rice, Joshua, Riverso, Marisa, Rogers, Elisabeth, Rose, Nevena, Runkle, Anne, Russell, Brittney, Russo, Christopher J., Ryan, Sydney, Sandelich, Stephen, Santry, Laura, Sapien, Robert E., Savage, Jillian Stevens, Scarfone, Richard J., Schremmer, Robert D., Schutzman, Sara A., Schwab, Sandra H., Selbst, Steven M., Sells, Laura L., Seo, Suzanne, Shook, Joan E., Singh, Sabina B., Smith, Nadine, Stevens, Martha W. (Molly), Szydlowski, Ellen G., Taylor, Alexandra A., Thompson, Amy D., Tsarouhas, Nicholas, Tunc, Emine M., Weihmiller, Sarah N., Woodward, George A. (Tony), Yusuf, Shabana, and Zomorrodi, Arezoo

Published
2025
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