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2. Effects of early rehabilitation on motor function, dyspnoea intensity, respiratory muscle performance and handgrip strength in patients with COVID-19: an observational study

Author

Polastri, Massimiliano, primary, Carbonara, Paolo, additional, Prediletto, Irene, additional, Gardini, Aldo, additional, Venturoli, Francesca, additional, Tagariello, Federico, additional, Neri, Lucia, additional, Carpano, Marco, additional, Pacilli, Angela Maria Grazia, additional, and Nava, Stefano, additional

Published
2022
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5. Contributors

Author

Ahmed, Asia A., primary, Albert, Richard K., additional, Allen, Mark S., additional, Arenberg, Douglas, additional, Bearfield, Phil, additional, Benfield, Thomas, additional, Berim, Ilya, additional, Bird, Kathryn G., additional, Birring, Surinder S., additional, Brander, Lukas, additional, Brown, Jeremy S., additional, Brown, Kevin K., additional, Bull, Todd M., additional, Burgos, Felip, additional, Calverley, Peter M.A., additional, Camus, Philippe, additional, Carbonara, Paolo, additional, Carlos, William Graham, additional, Cassivi, Stephen D., additional, Cavallazzi, Rodrigo, additional, Celli, Bartolome R., additional, Chang, William Y.C., additional, Chow, Chung-Wai, additional, Churg, Andrew M., additional, Cordier, Jean-François, additional, Cosio, Borja G., additional, Cottin, Vincent, additional, Culver, Bruce H., additional, Daley, Charles L., additional, Davies, Helen E., additional, Denlinger, Chadrick E., additional, Deroose, Christophe, additional, Deschamps, Claude, additional, Dooms, Christophe, additional, Downey, Gregory P., additional, Ferrer, Miquel, additional, Folz, Rodney J., additional, Garrity, Edward R., additional, Gifford, Alex H., additional, Glenny, Robb W., additional, Gray, Kelsey, additional, Green, Ruth H., additional, Gruber, Michael P., additional, Grutters, J.C., additional, Haas, Andrew R., additional, Hage, Chadi A., additional, Haldar, Pranabashis, additional, Hansell, David M., additional, Hart, Nicholas, additional, Herth, Felix J.F., additional, Highland, Kristin B., additional, Holmes, Andre, additional, Hurst, John R., additional, Iannuzzi, Michael C., additional, Barbé, Ferrán, additional, Jardin, Cyrielle, additional, Johnson, Simon R., additional, Kacmarek, Robert M., additional, Kariyawasam, Harsha H., additional, Kaufman, Joel D., additional, Kreit, John W., additional, Krowka, Michael J., additional, Lambert, Mark, additional, Lammers, J.-W.J., additional, Lapinsky, Stephen E., additional, Lee, Y.C. Gary, additional, Bassi, Gianluigi Li, additional, Lipman, Marc C.I., additional, Lomas, David A., additional, MacNee, William, additional, Mahler, Donald A., additional, Malo, Jean-Luc, additional, Marciniak, Stefan J., additional, Marin, José M., additional, Martínez-García, Miguel Ángel, additional, Mazzone, Peter, additional, McGlennan, Alan, additional, McShane, Pamela J., additional, Meniawy, Tarek, additional, Midthun, David E., additional, Miller, Robert F., additional, Moraes, Theo J., additional, Morris, Alison, additional, Mwenge, Gimbada B., additional, Nava, Stefano, additional, Newman, Lee S., additional, Okcay, Aynur, additional, Padley, Simon P.G., additional, Parameswaran, Ganapathi Iyer, additional, Pastis, Nicholas J., additional, Paul, Manju, additional, Pavord, Ian D., additional, Petersen, Hilary, additional, Polkey, Michael I., additional, Quint, Jennifer, additional, Rabe, Klaus F., additional, Ramsay, Michelle, additional, Ratjen, Felix, additional, Rezaei, M. Katayoon, additional, Rinne, Seppo T., additional, Robinson, Bruce W.S., additional, Roca, Josep, additional, Rodenstein, Daniel, additional, Rosado, Jaime Rodríguez, additional, Rosado-de-Christenson, Melissa L., additional, Rose, Cecile, additional, Rossi, Federico Fiorentino, additional, Ruiz, Luis G., additional, Scadding, Glenis K., additional, Schneider, Frank, additional, Schwartz, Arnold M., additional, Sergew, Amen, additional, Sethi, Sanjay, additional, Shaw, Penny J., additional, Simonds, Anita K., additional, Slutsky, Arthur S., additional, Specks, Ulrich, additional, Spiro, Jonathan R., additional, Spiro, Michael, additional, Spiro, Stephen G., additional, Steeds, Richard P., additional, Sterman, Daniel H., additional, Stinson, Kaylan E., additional, Stockley, Robert, additional, Strollo, Diane C., additional, Sulemanji, Demet S., additional, Tanoue, Lynn, additional, Taylor, Magali N., additional, Torres, Antoni, additional, Tullis, Elizabeth, additional, Vachani, Anil, additional, Vandenplas, Olivier, additional, Vansteenkiste, Johan, additional, Vassilakopoulos, Theodoros, additional, Veraldi, Kristen L., additional, Villar, Jesús, additional, Wagner, Peter D., additional, Wallaert, Benoit, additional, Walter, Nicholas, additional, Wedzicha, Jadwiga A., additional, Wells, Athol, additional, Whitters, Deborah, additional, Woodhead, Mark A., additional, Wright, Joanne L., additional, and Wrightson, John M., additional

Published
2012
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9. Malattia tromboembolica polmonare

Author

CARBONARA, PAOLO, COSMI, BENILDE, ZOMPATORI, MAURIZIO, D. Fantini, Mario Fabbri, P. Carbonara, B. Cosmi, D. Fantini, and M. Zompatori

Abstract

Trattazione degli aspetti epidemiologici, ezio-patogenetici, clinici, diagnostici e terapeutici della tromboembolia polmonare.

Published
2007

10. Polmoniti acquisite in comunità

Author

CARBONARA, PAOLO, ZOMPATORI, MAURIZIO, V. Livi, M. D'Avanzo, L. Piccari, M. FABBRI, P. Carbonara, V. Livi, M. D'Avanzo, L. Piccari, and M. Zompatori

Abstract

Presentazione degli aspetti epidemiologici, patogenetici, clinici e diagnostico-terapeutici delle polmoniti acquisite in comunità.

Published
2007

11. Interstitial lung disease (ILD) and gastroesophageal reflux (GER)

Author

BELMONTE, GELORMA, SALVIOLI, BEATRICE, FASANO, LUCA, PACILLI, ANGELA MARIA GRAZIA, DI SCIOSCIO, VALERIO, STANGHELLINI, VINCENZO, CARBONARA, PAOLO, CORINALDESI, ROBERTO, FABBRI, MARIO, Baldi E, Belmonte G, Salvioli B, Fasano L, Pacilli AMG, Di Scioscio V, Stanghellini V, Baldi E, Carbonara P, Corinaldesi R, and Fabbri M

Published
2006

14. Pulmonary statics in disease

Author

CARBONARA, PAOLO, Eidelman D. H., HAMID Q., MARTIN J.G., SHANNON J., Carbonara P., and Eidelman D.H.

Published
2005

19. Idiopathic pulmonary fibrosis and polymorphisms of the folate pathway genes

Author

Martinelli, Marcella, primary, Scapoli, Luca, additional, Carbonara, Paolo, additional, Valentini, Ilaria, additional, Girardi, Ambra, additional, Farinella, Francesca, additional, Mattei, Gabriella, additional, Pacilli, Angela Maria Grazia, additional, Fasano, Luca, additional, Nava, Stefano, additional, and Solmi, Rossella, additional

Published
2013
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22. Human Multidrug Resistance 1 gene polymorphisms and Idiopathic Pulmonary Fibrosis.

Author

Martinelli, Marcella, Scapoli, Luca, Pacilli, Angela Maria Grazia, Carbonara, Paolo, Girardi, Ambra, Mattei, Gabriella, Rodia, Maria Teresa, and Solmi, Rossella

Subjects
ACADEMIC medical centers, CHI-squared test, CONFIDENCE intervals, STATISTICAL correlation, DRUG resistance, GENETIC polymorphisms, POLYMERASE chain reaction, RESEARCH funding, DATA analysis software, IDIOPATHIC pulmonary fibrosis, ODDS ratio, GENOTYPES
Abstract

Background: For the first time we tested an association between the human multidrug resistance gene 1 (MDR1) polymorphisms (SNPs) and idiopathic pulmonary fibrosis (IPF). Several MDR1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics. Materials and Methods: We genotyped three MDR1 polymorphisms of 48 IPF patients and 100 control subjects with Italian origins. Results: No evidence of association was detected. Conclusion: There are 50 known MDR1 SNPs, and their role is explored in terms of the effectiveness of drug therapy. We consider our small-scale preliminary study as a starting point for further research. [ABSTRACT FROM AUTHOR]

Published
2015

24. Influence of the Admission Pattern on the Outcome of Patients Admitted to a Respiratory Intensive Care Unit: Does a Step-Down Admission Differ From a Step-Up One?

Author

Valentini, Ilaria, Pacilli, Angela Maria Grazia, Carbonara, Paolo, Fasano, Luca, Vitale, Rita, Zenesini, Corrado, Melotti, Rita Maria, Faenza, Stefano, and Nava, Stefano

Subjects
HOSPITAL admission & discharge, AGE distribution, ANALYSIS of variance, STATISTICAL correlation, CAUSES of death, EPIDEMIOLOGY, HEALTH status indicators, HOSPITAL wards, HOSPITALS, HOSPITAL respiratory services, LONGITUDINAL method, EVALUATION of medical care, DEATH rate, MULTIVARIATE analysis, PATIENTS, SERUM albumin, SEX distribution, STATISTICS, SURVIVAL analysis (Biometry), MECHANICAL ventilators, COMORBIDITY, LOGISTIC regression analysis, DATA analysis, ACTIVITIES of daily living, CONTINUING education units, DATA analysis software, DESCRIPTIVE statistics, NUTRITIONAL status
Abstract

BACKGROUND: The outcomes of patients admitted to a respiratory ICU (RICU) have been evaluated in the past, but no study has considered the influence of location prior to RICU admission. METHODS: We analyzed prospectively collected data from 326 consecutive patients admitted to a 7-bed RICU. The primary end points were survival and severity of morbidity-related complications, evaluated according to the patient's location prior to RICU admission. Three admission pathways were considered: step-down for patients transferred from the ICUs of our hospital; step-up for patients coming from our respiratory wards or other medical wards; and directly for patients coming from the emergency department. The secondary end point was the potential influence of several risk factors for morbidity and mortality. RESULTS: Of the 326 subjects, 92 (28%) died. Overall, subjects admitted in a step-up process had a significantly higher mortality (P < .001) than subjects in the other groups. The mortality rate was 64% for subjects admitted from respiratory ward, 43% for those from medical wards, and 18% for subjects from both ICU and emergency department (respiratory ward vs medical ward P = .04, respiratory ward vs emergency department P < .001, respiratory ward vs ICU P < .001, medical ward vs emergency department P < .001, and medical ward vs ICU P < .001). Subjects admitted from a respiratory ward had a lower albumin level, and Simplified Acute Physiology Score II was significantly higher in subjects following a step-up admission. About 30% of the subjects admitted from a respiratory ward received noninvasive ventilation as a "ceiling treatment." The highest odds ratios related to survival were subject location prior to RICU admission and female sex. Lack of use of noninvasive ventilation, younger age, female sex, higher albumin level, lower Simplified Acute Physiology Score II, higher Barthel score, and absence of chronic heart failure were also statistically associated with a lower risk of death. CONCLUSIONS: The pathway of admission to a RICU is a determinant of outcome. Patients following a step-up pattern are more likely to die. Other major determinants of survival are age, nutritional status and female sex. [ABSTRACT FROM AUTHOR]

Published
2013
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25. Human multidrug resistance 1 gene polymorphisms and idiopathic pulmonary fibrosis

Author

Marcella Martinelli, Scapoli, Luca, Pacilli, Angela Maria Grazia, Carbonara, Paolo, Girardi, Ambra, Mattei, Gabriella, Rodia, Maria Teresa, Solmi, Rossella, Martinelli, Marcella, Scapoli, Luca, Pacilli, Angela Maria Grazia, Carbonara, Paolo, Girardi, Ambra, Mattei, Gabriella, Rodia, Maria Teresa, and Solmi, Rossella

Subjects
Idiopathic pulmonary fibrosi, Short Communication, lcsh:R, polycyclic compounds, lcsh:Medicine, Idiopathic pulmonary fibrosis, multidrug resistance 1 gene, neoplasms, physiological processes, polymorphism
Abstract

Background: For the first time we tested an association between the human multidrug resistance gene 1 (MDR1) polymorphisms (SNPs) and idiopathic pulmonary fibrosis (IPF). Several MDR1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics. Materials and Methods: We genotyped three MDR1 polymorphisms of 48 IPF patients and 100 control subjects with Italian origins. Results: No evidence of association was detected. Conclusion: There are 50 known MDR1 SNPs, and their role is explored in terms of the effectiveness of drug therapy. We consider our small-scale preliminary study as a starting point for further research.

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