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2,331 results on '"CHAI, YI"'

1. Resonant Quantum Magnetodielectric Effect in Multiferroic Metal-Organic Framework [CH3NH3]Co(HCOO)3

Author

Su, Na, Liu, Shuang, He, Yingjie, Liu, Yan, Fu, Huixia, Chai, Yi-Sheng, and Sun, Young

Subjects
Condensed Matter - Materials Science
Abstract

We report the observation of both resonant quantum tunneling of magnetization (RQTM) and resonant quantum magnetodielectric (RQMD) effect in the perovskite multiferroic metal-organic framework [CH3NH3]Co(HCOO)3. An intrinsic magnetic phase separation emerges at low temperatures due to hydrogen-bond-modified long range super-exchange interaction, leading to the coexistence of canted antiferromagnetic order and single-ion magnet. Subsequently, a stair-shaped magnetic hysteresis loop along the [101] direction characterizing the RQTM appears below the magnetic blocking temperature. More interestingly, the magnetic field dependence of dielectric permittivity exhibits pronounced negative peaks at the critical fields corresponding to the RQTM, a phenomenon termed the RQMD effect which enables electrical detection of the RQTM. These intriguing properties make the multiferroic metal-organic framework a promising candidate for solid-state quantum computing., Comment: 13 pages, 4 figures

Published
2024

2. Atacama Large Aperture Submillimeter Telescope (AtLAST) Science: Solar and stellar observations

Author

Wedemeyer, Sven, Barta, Miroslav, Brajsa, Roman, Chai, Yi, Costa, Joaquim, Gary, Dale, de Castro, Guillermo Gimenez, Gunar, Stanislav, Fleishman, Gregory, Hales, Antonio, Hudson, Hugh, Kirkaune, Mats, Mohan, Atul, Motorina, Galina, Pellizzoni, Alberto, Saberi, Maryam, Selhorst, Caius L., Simoes, Paulo J. A., Shimojo, Masumi, Skokic, Ivica, Sudar, Davor, Menezes, Fabian, White, Stephen, Booth, Mark, Klaassen, Pamela, Cicone, Claudia, Mroczkowski, Tony, Cordiner, Martin A., Di Mascolo, Luca, Johnstone, Doug, van Kampen, Eelco, Lee, Minju, Liu, Daizhong, Maccarone, Thomas, Orlowski-Scherer, John, Saintonge, Amelie, Smith, Matthew, and Thelen, Alexander E.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Observations at (sub-)millimeter wavelengths offer a complementary perspective on our Sun and other stars, offering significant insights into both the thermal and magnetic composition of their chromospheres. Despite the fundamental progress in (sub-)millimeter observations of the Sun, some important aspects require diagnostic capabilities that are not offered by existing observatories. In particular, simultaneously observations of the radiation continuum across an extended frequency range would facilitate the mapping of different layers and thus ultimately the 3D structure of the solar atmosphere. Mapping large regions on the Sun or even the whole solar disk at a very high temporal cadence would be crucial for systematically detecting and following the temporal evolution of flares, while synoptic observations, i.e., daily maps, over periods of years would provide an unprecedented view of the solar activity cycle in this wavelength regime. As our Sun is a fundamental reference for studying the atmospheres of active main sequence stars, observing the Sun and other stars with the same instrument would unlock the enormous diagnostic potential for understanding stellar activity and its impact on exoplanets. The Atacama Large Aperture Submillimeter Telescope (AtLAST), a single-dish telescope with 50\,m aperture proposed to be built in the Atacama desert in Chile, would be able to provide these observational capabilities. Equipped with a large number of detector elements for probing the radiation continuum across a wide frequency range, AtLAST would address a wide range of scientific topics including the thermal structure and heating of the solar chromosphere, flares and prominences, and the solar activity cycle. In this white paper, the key science cases and their technical requirements for AtLAST are discussed., Comment: 14 pages, 4 figures, submitted to Open Research Europe as part of a collection on the Atacama Large Aperture Submillimeter Telescope (AtLAST)

Published
2024

10. A Novel Transparent Object Detection Approach Based on Boundary Optimization

Author

Wang, Hanfang, Chai, Yi, Tao, Tao, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, and S. Shmaliy, Yuriy, editor

Published
2024
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11. Evaluating Non-LTE Spectral Inversions with ALMA and IBIS

Author

Hofmann, Ryan, Reardon, Kevin, Milic, Ivan, Molnar, Momchil, Chai, Yi, and Uitenbroek, Han

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

We present observations of a solar plage in the millimeter-continuum with the ALMA and in the Ca 8542 and Na 5896 spectral lines with the Interferometric BIdimensional Spectrometer (IBIS). Our goal is to compare the measurement of local gas temperatures provided by ALMA with the temperature diagnostics provided by non-LTE inversions using STIC. In performing these inversions, we find that using column mass as the reference height scale, rather than optical depth, provides more reliable atmospheric profiles above the temperature minimum and that the treatment of non- LTE hydrogen ionization brings the inferred chromospheric temperatures into better agreement with the ALMA measurements. The Band 3 brightness temperatures are higher but well correlated with the inversion-derived temperatures at the height of formation of the Ca 8542 line core. The Band 6 temperatures instead do not show good correlations with the temperatures at any specific layer in the inverted atmospheres. We then performed inversions that included the millimeter continuum intensities as an additional constraint. Incorporating Band 3 generally resulted in atmospheres showing a strong temperature rise in the upper atmosphere, while including Band 6 led to significant regions of anomalously low temperatures at chromospheric heights. This is consistent with the idea that the Band 6 emission can come from a range of heights. The poor constraints on the chromospheric electron density with existing inversion codes introduces difficulties in determining the height(s) of formation of the millimeter continuum as well as uncertainties in the temperatures derived from the spectral lines., Comment: 23 pages, 17 figures

Published
2022
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15. Factors influencing brand equity: Testing Aaker’s brand equity framework in Malaysian toy industry

Author

Wong Chee Hoo, Chai Yi Xin, and Visal Moosa

Subjects
brand associations, brand awareness, brand equity, brand loyalty, Malaysia, perceived brand quality, Marketing. Distribution of products, HF5410-5417.5
Abstract

Previous studies have demonstrated varying associations between fundamental components of brand equity within diverse sectors. The purpose of the current study is to examine the influence of Aaker’s brand equity model’s dimensions (brand awareness, brand loyalty, perceived quality, and brand association) on brand equity in the context of toy brands in Malaysia. The study employs a quantitative-based correlation design within a non-controlled setting, using a cross-sectional approach with individuals as the unit of analysis. The population consists of respondents from the general public aged 18 and above, as they are valid buyers of toys. Data collection was conducted using a non-probability sampling method. The questionnaire was sent to the targeted respondents using online Google Form links. A comprehensive dataset from 384 respondents was gathered for descriptive analysis of the demographic profile. Hypothesis testing was performed using regression analysis. The findings indicate that, except for brand associations, the remaining three factors – perceived quality (Beta = .377, p < .001), brand loyalty (Beta = .338, p < .001), and brand awareness (Beta = .221, p < .01) – exhibit a statistically significant positive correlation with the brand equity of children’s toy brands in Malaysia. AcknowledgmentThe authors thank INTI International University, Malaysia, for providing financial support to publish this paper.

Published
2024
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18. A study of sunspot 3 minute oscillations using ALMA and GST

Author

Chai, Yi, Gary, Dale E., Reardon, Kevin P., and Yurchyshyn, Vasyl

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Waves and oscillations are important solar phenomena, not only because they can propagate and dissipate energy in the chromosphere, but also because they carry information about the structure of the atmosphere in which they propagate. The nature of the three-minute oscillations observed in the umbral region of sunspots is considered to be an effect of propagation of magnetohydrodynamic (MHD) waves upward from below the photosphere. We present a study of sunspot oscillations and wave propagation in NOAA AR 12470 using an approximately one-hour long data set acquired on 2015 December 17 by the Atacama Large Millimeter/submillimeter Array (ALMA), the Goode Solar Telescope (GST) operating at the Big Bear Solar Observatory (BBSO), the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory (SDO), and the Interface Region Imaging Spectrograph (IRIS). The ALMA data are unique in providing a time-series of direct temperature measurements in the sunspot chromosphere. The two-second cadence of ALMA images allows us to well resolve the three-minute periods typical of sunspot oscillations in the chromosphere. Fourier analysis is applied to ALMA Band 3 ($\sim$100 GHz, $\sim$3 mm) and GST H$\alpha$ data sets to obtain power spectra as well as oscillation phase information. We analysed properties of the wave propagation by combining multiple wavelengths that probe physical parameters of solar atmosphere at different heights. We find that the ALMA temperature fluctuations are consistent with that expected for a propagating acoustic wave, with a slight asymmetry indicating non-linear steepening., Comment: 18 pages, 13 figures

Published
2021
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19. Giant magnetostriction and nonsaturating electric polarization up to 60 T in the polar magnet CaBaCo4O7

Author

Chai, Yi-Sheng, Cong, Jun-Zhuang, He, Jin-Cheng, Su, Dan, Ding, Xia-Xin, Singleton, John, Zapf, Vivien, and Sun, Young

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

Giant magnetostriction in insulating magnetic materials is highly required for applications but is rarely observed. Here we show that giant magnetostriction (> 1500 ppm) can be achieved in an insulating transition metal oxide CaBaCo4O7 where the ferrimagnetic ordering at TC ~ 62 K is associated with a huge change in the lattice. Moreover, because this material is pyroelectric with a non-switchable electric polarization (P), the giant magnetostriction results in a record-breaking magnetoelectric effect - a gigantic change of electric polarization (deltaP ~ 1.6 {\mu}C/cm2) in response to the applied magnetic field up to 60 T. Geometric frustration as well as the orbital instability of Co2+/Co3+ ions is believed to play a crucial role in the giant magnetostriction. Our study provides new insights on how to achieve both giant magnetostriction and pronounced magnetoelectric effect in insulating transition metal oxides., Comment: 17 pages, 4 figures

Published
2021
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28. High-frequency wave power observed in the solar chromosphere with IBIS and ALMA

Author

Molnar, Momchil E., Reardon, Kevin P., Cranmer, Steven R., Kowalski, Adam F., Chai, Yi, and Gary, Dale

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

We present observational constraints on the solar chromospheric heating contribution from acoustic waves with frequencies between 5 and 50 mHz. We utilize observations from the Dunn Solar Telescope in New Mexico complemented with observations from the Atacama Large Millimeter Array collected on 2017 April 23. The properties of the power spectra of the various quantities are derived from the spectral lines of Ca II 854.2 nm, H I 656.3 nm, and the millimeter continuum at 1.25 mm and 3 mm. At the observed frequencies the diagnostics almost all show a power law behavior, whose particulars (slope, peak and white noise floors) are correlated with the type of solar feature (internetwork, network, plage). In order to disentangle the vertical versus transverse plasma motions we examine two different fields of view; one near disk center and the other close to the limb. To infer the acoustic flux in the middle chromosphere, we compare our observations with synthetic observables from the time-dependent radiative hydrodynamic RADYN code. Our findings show that acoustic waves carry up to about 1 kW m$^{-2}$ of energy flux in the middle chromosphere, which is not enough to maintain the quiet chromosphere, contrary to previous publications., Comment: Accepted for publication in ApJ

Published
2021
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29. Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability

Author

Gaggioli, Vincent, Lo, Calvin S. Y., Reverón-Gómez, Nazaret, Jasencakova, Zuzana, Domenech, Heura, Nguyen, Hong, Sidoli, Simone, Tvardovskiy, Andrey, Uruci, Sidrit, Slotman, Johan A., Chai, Yi, Gonçalves, João G. S. C. Souto, Manolika, Eleni Maria, Jensen, Ole N., Wheeler, David, Sridharan, Sriram, Chakrabarty, Sanjiban, Demmers, Jeroen, Kanaar, Roland, Groth, Anja, and Taneja, Nitika

Published
2023
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36. Dynamic Estimation of Loads on Wind Turbine Blades Based on Sensor Optimization and Kalman Filter

Author

Chen, Hang, Wei, Shanbi, Wang, Yu, Chai, Yi, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Jia, Yingmin, editor, Zhang, Weicun, editor, Fu, Yongling, editor, and Wang, Jiqiang, editor

Published
2023
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37. Early Gastric Cancer Screening Framework Based on Multimodal Fusion

Author

Lu, Meichen, Chai, Yi, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Jia, Yingmin, editor, Zhang, Weicun, editor, Fu, Yongling, editor, and Wang, Jiqiang, editor

Published
2023
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38. An Anomaly Detection Algorithm for Logs Based on Self-attention Mechanism and BiGRU Model

Author

Yang, Han, Lin, Fuliang, Chai, Yi, Qie, Kaiming, Lin, Wenyi, Wang, Yuanyuan, Zhang, Cheng, Guo, Maoyun, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Jia, Yingmin, editor, Zhang, Weicun, editor, Fu, Yongling, editor, and Wang, Jiqiang, editor

Published
2023
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39. Identity Consistency Construction for Visible-Infrared Person Re-identification in Cloud Environment

Author

Wang, Yiming, Xu, Kaixiong, Chai, Yi, Li, Shuo, Jiang, Yutao, Liu, Bowen, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Jia, Yingmin, editor, Zhang, Weicun, editor, Fu, Yongling, editor, and Wang, Jiqiang, editor

Published
2023
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40. A Distributed Processing Method for Large Scale Logs

Author

Yang, Han, Lin, Fuliang, Chai, Yi, Qie, Kaiming, Li, Shuo, Wang, Yuanyuan, Zhang, Cheng, Guo, Maoyun, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Jia, Yingmin, editor, Zhang, Weicun, editor, Fu, Yongling, editor, and Wang, Jiqiang, editor

Published
2023
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41. Nonlinear-Drift-Driven Wiener Process–Markov Chain Switching Model for Predicting Lithium-Ion Battery Remaining Useful Life

Author

Zhang, Yixing, Feng, Fei, Wang, Shunli, Meng, Jinhao, Xie, Jiale, Yin, Hongpeng, Chai, Yi, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Sun, Fengchun, editor, Yang, Qingxin, editor, Dahlquist, Erik, editor, and Xiong, Rui, editor

Published
2023
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42. Selinexor, bortezomib, and dexamethasone versus bortezomib and dexamethasone in previously treated multiple myeloma: Outcomes by cytogenetic risk.

Author

Richard, Shambavi, Chari, Ajai, Delimpasi, Sosana, Simonova, Maryana, Spicka, Ivan, Pour, Ludek, Kriachok, Iryna, Dimopoulos, Meletios, Pylypenko, Halyna, Auner, Holger, Leleu, Xavier, Usenko, Ganna, Hajek, Roman, Benjamin, Reuben, Dolai, Tuphan, Sinha, Dinesh, Venner, Christopher, Garg, Mamta, Stevens, Don, Quach, Hang, Jagannath, Sundar, Moreau, Phillipe, Levy, Moshe, Badros, Ashraf, Anderson, Larry, Bahlis, Nizar, Facon, Thierry, Mateos, Maria, Cavo, Michele, Chang, Hua, Landesman, Yosef, Chai, Yi, Arazy, Melina, Shah, Jatin, Shacham, Sharon, Kauffman, Michael, Grosicki, Sebastian, and Richardson, Paul

Subjects
Adult, Aged, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Bortezomib, Cytogenetic Analysis, Dexamethasone, Female, Humans, Hydrazines, Male, Middle Aged, Multiple Myeloma, Progression-Free Survival, Treatment Outcome, Triazoles, Young Adult
Abstract

In the phase 3 BOSTON study, patients with multiple myeloma (MM) after 1-3 prior regimens were randomized to once-weekly selinexor (an oral inhibitor of exportin 1 [XPO1]) plus bortezomib-dexamethasone (XVd) or twice-weekly bortezomib-dexamethasone (Vd). Compared with Vd, XVd was associated with significant improvements in median progression-free survival (PFS), overall response rate (ORR), and lower rates of peripheral neuropathy, with trends in overall survival (OS) favoring XVd. In BOSTON, 141 (35.1%) patients had MM with high-risk (presence of del[17p], t[4;14], t[14;16], or ≥4 copies of amp1q21) cytogenetics (XVd, n = 70; Vd, n = 71), and 261 (64.9%) exhibited standard-risk cytogenetics (XVd, n = 125; Vd, n = 136). Among patients with high-risk MM, median PFS was 12.91 months for XVd and 8.61 months for Vd (HR, 0.73 [95% CI, (0.4673, 1.1406)], p = 0.082), and ORRs were 78.6% and 57.7%, respectively (OR 2.68; p = 0.004). In the standard-risk subgroup, median PFS was 16.62 months for XVd and 9.46 months for Vd (HR 0.61; p = 0.004), and ORRs were 75.2% and 64.7%, respectively (OR 1.65; p = 0.033). The safety profiles of XVd and Vd in both subgroups were consistent with the overall population. These data suggest that selinexor can confer benefits to patients with MM regardless of cytogenetic risk. ClinicalTrials.gov identifier: NCT03110562.

Published
2021

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