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Your search keyword '"CHANNER, KEVIN S."' showing total 324 results
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324 results on '"CHANNER, KEVIN S."'

12. A randomised controlled trial of warfarin versus aspirin for stroke prevention in octogenarians with atrial fibrillation (WASPO)

Author

Rash, Amar, Downes, Tom, Portner, Robin, Yeo, Wilf W., Morgan, Nicollette, and Channer, Kevin S.

Subjects
Aspirin -- Health aspects, Aspirin -- Comparative analysis, Atrial fibrillation -- Complications and side effects, Aged -- Health aspects, Stroke (Disease) -- Prevention, Warfarin -- Health aspects, Warfarin -- Comparative analysis, Health, Psychology and mental health, Seniors, Social sciences
Published
2007

30. The normal range for inter-arm differences in blood pressure

Author

Orme, Susan, Ralph, Susan G., Birchall, Andrew, Lawson-Matthew, Peter, McLean, Katherine, and Channer, Kevin S.

Subjects
Aged -- Health aspects, Blood pressure -- Measurement, Heart -- Contraction, Diastole (Cardiac cycle) -- Research, Dissecting aneurysm -- Research, Health, Psychology and mental health, Seniors, Social sciences
Published
1999

35. Evaluation of a protocol to select patients of all ages for cardioversion from atrial fibrillation

Author

Lawson-Matthew, Peter J., Ionescu, Adrian, McHugh, Patrick, and Channer, Kevin S.

Subjects
Cardiology -- Research, Aged patients -- Research, Electric countershock -- Research, Atrial fibrillation -- Research, Cardiac patients -- Research, Health, Psychology and mental health, Seniors, Social sciences, Research
Abstract

Abstract Objective: to audit the success of a decision protocol to select patients for cardioversion from atrial fibrillation or flutter by recording the success of cardioversion and the maintenance of [...]

Published
1997

43. To the editor

Author

Pugh, Peter J., Malkin, Christopher J., and Channer, Kevin S.

Published
2003

50. Study protocol to investigate the effects of testosterone therapy as an adjunct to exercise rehabilitation in hypogonadal males with chronic heart failure

Author

Mathur Atish, Zwierska Irena, Saxton John M, and Channer Kevin S

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Testosterone deficiency is a common occurrence in men with chronic heart failure (CHF) and may underpin features of advanced disease, including reduced skeletal muscle mass and fatigue. It is positively correlated with cardiac output and exercise capacity in patients with CHF, whereas a significant improvement in both these parameters has been observed following testosterone replacement therapy. Testosterone therapy has also been shown to reduce circulating levels of inflammatory markers, (TNF-α, sICAM-1 and sVCAM-1) in patients with established coronary artery disease and testosterone deficiency. This pilot study will assess the feasibility of a combined exercise rehabilitation and adjunctive testosterone therapy intervention for evoking improvements in exercise capacity, circulating inflammatory markers, cardiac and skeletal muscle function, indices of psychological health status and quality of life in hypogonadal males with chronic heart failure. Methods/design Following ethical approval, 36 patients will be randomly allocated to one of two groups: testosterone or placebo therapy during exercise rehabilitation. A combined programme of moderate intensity aerobic exercise and resistance (strength) training will be used. The primary outcome measure is exercise capacity, assessed using an incremental shuttle walk test. Secondary outcome measures include measures of peak oxygen uptake, cardiac function, lower-limb skeletal muscle contractile function and oxygenation during exercise, circulating inflammatory markers, psychological health status and quality of life. Discussion Exercise rehabilitation can safely increase exercise capacity in stable CHF patients but there is a need for studies which are aimed at evaluating the long-term effects of physical training on functional status, morbidity and mortality. This pilot study will provide valuable preliminary data on the efficacy of testosterone therapy as an adjunct to exercise rehabilitation on a range of functional, physiological and health-related outcomes in this patient population. Preliminary data will be used in the design of a large-scale randomised controlled trial, aimed at informing clinical practice with respect to optimisation of exercise rehabilitation in this patient group.

Published
2006
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