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11th World Congress for Neurorehabilitation , LYON, FRANCE, 07-/10/2020 - 10/10/2020; Question: Non-pharmacologic treatment such as physical exercise has been proven to have beneficial effects on gait disorders in Parkinson's disease (PD). In Lyon (France), Sirroco rehabilitation program is a novel, collective, multidisciplinary program focused on intensive, high amplitude movements, and loudness of speech for patients with PD. However, the effects of physical exercise on dorsolateral prefrontal cortex (DLPFC) activity in patients with PD is still elusive. The main aim of this pilot study was to assess the effects of the Sirocco program in patients with PD on DLPFC activity on single task (ST) and dual-task (DT) walking. Methods: Fourteen PD patients (mean: 66.9 y.o ± 8.1) completed Sirocco sessions for 5 weeks. Changes in oxyhemoglobin concentration (?HbO2) in the DLPFC were measured using functional Near Infrared Spectroscopy during three walking tasks conditions: (1) ST walking, (2) DT walking while counting forward and (3) DT walking while subtracting. Participants were assessed three times: five weeks before the program (T0); few days before (T1) and one week after the program (T2). Walking performance (mean stride time and cadence) was also recorded using foot-sensors. The gain in performance was calculated by subtracting values at T0 and T1 or at T2 and at T1. Results: Significant differences were observed in ?HbO2 between the three times only for the ST walking: ?HbO2 were significantly higher at T1 than at T0 whereas ?HbO2 was lower in T2 than in T1 (p

WCNR, 11th World Congress for Neurorehabilitation, Lyon, FRANCE, 07-/10/2020 - 11/10/2020; 1.Question: Patients with Parkinson disease (PD) report difficulties walking while performing another task. Dual-task (DT) walking may therefore increase the risk of falls. To date, the effect of DT walking on brain activity is not well understood. The objective of this pilot study was to examine dorsolateral prefrontal cortex activity (DLPFC) during single-task (ST) and DT walking conditions in PD patients. 2.Methods: Thirteen patients with PD (mean age: 66 ± 7 years, 8 men, UPDRS motor score (/108): 23 ± 11, Montreal Cognitive Assessment (MoCA) score: 27 ± 2) and 13 healthy older adults (mean age: 64 ± 7 years, 8 men, MoCA score: 28 ± 3) performed three walking tasks: [1] ST walking, [2] DT walking while counting forward (+1) and [3] DT walking while subtracting (-7). Cortical activity in DLPFC, assessed by changes in oxy-haemoglobin (?HbO2) was measured using functional near infrared spectroscopy (NIRSport). Gait performance (speed, cadence and stride length) was recorded simultaneously using wearables sensors (Gait-Up sensors). 3. Results: In ST walking and DT walking while subtracting conditions, ?HbO2 was higher in patients than in controls (p < 0.05). No significant differences in ?HbO2 were found between ST and the two DT-walking conditions in patients whereas ?HbO2 was significantly higher in DT-walking conditions than in ST walking in controls. As expected, patients had reduced walking speed, cadence and stride length compared to controls, regardless of conditions (p < 0.05). Variability of their cadence increased as the walking task difficulty increased, which is not the case for controls. 4. Conclusion This pilot study suggests that dorsolateral prefrontal cortex plays a major role already during ST walking condition in patients in relatively early stages of PD. This may suggest that patients recruit additional cognitive resources, as a measure of cognitive compensation to perform the ST walking. These findings may have implications for rehabilitation of gait in patients with PD, improving automaticity in simple tasks. Another ongoing study will show the effect of an exercise-based intervention program (SIROCCO program) on DLPFC activity while walking in the same group of patients with PD.

Les 31èmes Entretiens Jacques Cartier, Bron, FRANCE, 13-/11/2018 - 14/11/2018; Évaluer les effets d'un programme de rééducation intensive nommé SIROCCO sur les capacités cognitives et motrices. Programme réalisé à l'hôpital Henry Gabrielle, Saint-Genis-Laval. Les premiers résultats comparant les performances de deux patients ayant eu une évaluation avant et après le programme SIROCCO montrent que les capacités motrices liées à la marche sont améliorées.