11,346 results on '"CHEN Chuan"'
Search Results
2. Quality comparability analysis on production site change of human coagulation factor Ⅷ
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TIAN Tianli, WANG Hanyu, MA Yiyun, XUE Wei, ZHANG Shengchao, ZHANG Yaoyin, ZHOU Shunbo, ZOU Lingling, CHEN Chuan, and DING Yaling
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human coagulation factor ⅷ(fⅷ) ,site change ,quality indexes ,Diseases of the blood and blood-forming organs ,RC633-647.5 ,Medicine - Abstract
Objective To study the quality comparability of human coagulation factor Ⅷ (FⅧ) produced before and after the change of factory site. Methods A comparative study was carried out on quality quantitative indexes, related impurities and stability data of FⅧ produced before and after the change of factory site. Results The FⅧ quantitative quality before and after the change of factory site all met the quality standard, and the related impurities including aluminum residue, tributyl phosphate residue, polysorbate 80 residue and PEG residue all met the quality standard. Other impurities including human fibrinogen, fibronectin, plasminogen, IgA, IgM and IgG were extremely low in content and equivalent in quality. The content of VWF (von Willebrand factor) had no obvious change before and after the change of factory site, but was significantly higher than that of other domestic manufacturers’ commercial products. The results of accelerated stability and long-term stability tests showed that the titer of FⅧ fluctuated within the methodological error range, and the results all met the quality standard. Conclusion The change of factory site of FⅧ has no effect on the quality.
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- 2024
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3. Impact of precipitation on soil moisture in seasonal drought regions in Southwest China
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ZHANG Manxue, LUO Houpan, CHEN Chuan, YU Kangning, CHEN Taiyang, HUANG Rong, and LIU Zhandong
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soil water content ,rainfall ,southwest seasonal drought regions ,farmland ,crop ,Agriculture (General) ,S1-972 ,Irrigation engineering. Reclamation of wasteland. Drainage ,TC801-978 - Abstract
【Objective】 Soil water is not only a resource to plants but also controls microbial activity and biogeochemical processes which are essential for ecosystem functions. Its spatiotemporal dynamics is controlled by a multitude of biotic and abiotic processes. In this paper, we investigate the response of soil water dynamics to rainfall events in the seasonal drought regions in Southwest China. 【Method】 The study was based on in-situ observations and rainfalls and soil water content measured from April to October 2023 across the region. Using these data, we analyzed the response of soil water content in paddy and corn fields to rainfall events with different intensities. 【Result】 ① Rainfall intensities affected penetration depths of the rainfall water. Rainfall events less than 2 mm/h affected the soil water mainly in the 0-20 cm soil layer, while rainfall events with intensity greater than 2 mm/h but less than 8 mm/h affected soil water in the 0-50 cm soil layer. ② The responses of soil water to rainfall events varied with crops. For the corn and paddy fields, the mean effective recharge efficiency were 0.72%/h and 1.07%/h, the mean effective recharge lag time were 0.88 h and 5.38 h, and the mean regression rates were 0.04%/h and 0.02%/h, respectively, during the experimental period. ③ Compared with the corn fields, the paddy fields were more sensitive to rainfall, probably due to the difference in canopy interception of the crown leaves and water uptake of the roots between the two crops. The initial soil water content also affected the response of soil water to rainfall events. 【Conclusion】 Heavy rainfall events can effectively recharge soil water. Irrigation is needed for both crops during dry periods or periods in which rainfalls were less than 2 mm/h.
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- 2024
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4. Detection methods and biological treatment of typical organic compounds in tail water of chemical/pharmaceutical industrial parks
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YANG Lei, FU Ruotong, JIN Wenhui, FU Shiying, SHAO Zhen, WANG Xueting, and CHEN Chuan
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industrial wastewater ,typical organic compounds ,gas chromatography-mass spectrometry ,high performance liquid chromatography ,biological treatment ,Renewable energy sources ,TJ807-830 ,Environmental protection ,TD169-171.8 - Abstract
In order to meet the demand for the identification and detection of high-risk environmental pollutants in industrial park tail water, this paper adopted the gas chromatography-mass spectrometry (GC-MS) method to achieve the rapid qualitative analysis of alkanes, olefins, benzenes, ketones, alcohols, esters, acids, and other organics in the tail water of chemical/ pharmaceutical industrial parks. Based on the production process and water quality research and analysis of key enterprises within the industrial park, typical organic compounds, including 3-hexanol, 3-hexanone, methyl 3-(3,5-di-tertbutyl-4-hydroxyphenyl) propionate, and 4-bromo-2,6-di-tert-butylphenol were selected. A high-performance liquid chromatography (HPLC) method was established to analyze these compounds in the tail water achieving recoveries of 80% to 97% and the average recoveries of 87% to 95%. Furthermore aerobic and anaerobic biological sequential batch experiments were conducted to verify the biodegradation effect of these typical organics. The results showed that aerobic treatment was more effective than anaerobic treatment, with concentration removal rates ranging from 48.0% to 88.8%, COD removal rates from 70.8% to 99.9%, and average TOC removal rates from 54.7% to 79.5%. These findings provide theoretical and technological support for the further studies on advanced treatment technology or the upgrading and transformation of processes for industrial wastewater.
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- 2024
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5. Automated geometric precise correction of medium remote sensing images based on ASTER global digital elevation model
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Yanxia Wang, Ye Jiangxia, Chen Chuan, and Ruliang Zhou
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digital elevation model ,remote sensing image ,terrain feature lines ,ground control points ,geometric precise correction ,Physical geography ,GB3-5030 - Abstract
Accurate and unified information from the increasingly remote sensing (RS) scenes is important for RS applications in multi-sectoral association services of natural resource management. However, these applications in mountain areas are limited by the challenging issues of random geometric distortions and erroneous spatial associations. The paper introduces digital elevation model (DEM) maps as a unified geographic reference to search and match homonymy ground points (HGPs). The proposed computer-based procedure was tested with Landsat TM, ETM and HJ-1B satellite images using ASTER global DEM in the Longitudinal Rang-gorge Valley Region of Southwest China. 1322, 3551 and 694 pairs of HGPs were identified and acquired the geometric accuracies with 43 m (TM), 14 m (ETM) and 123 m (HJ), respectively. The deviations are significantly reduced and the disjoint ground objects are matched. The study satisfies the application requirement of multispectral satellite imagery with less labour and time costs.
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- 2023
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6. Forecast of new energy vehicle ownership in key cities in China
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Liang Panchun, Chen Chuan, and Li Hongwei
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Environmental sciences ,GE1-350 - Abstract
With the rapid development of the electric vehicle industry, the future number of new energy vehicle(NEV) will play a key role in urban planning and the infrastructure layout of NEV development such as charging piles. This paper aims to forecast the future vehicle ownership and NEV ownership in ten key cities in China through authoritative data and scientific forecasting methods, discuss the characteristics and differences of NEV development in different cities, and provide a reference for government policy formulation and enterprise industrial layout.
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- 2024
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7. Development of intelligent delineation model for clinical target volume of nasopharyngeal carcinoma based on integrated clinical health care system
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HE Rong, CHEN Chuan, LI Mengxia, XIAO He, and ZHONG Liangzhi
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nasopharyngeal carcinoma ,clinical target volume ,artificial intelligence ,dice similarity coefficient ,Medicine (General) ,R5-920 - Abstract
Objective To established an intelligent delineation model of clinical target volume (CTV) for nasopharyngeal carcinoma (NPC) using artificial intelligence (AI) technology to improve the efficiency and the accuracy of CTV delineation among various radiotherapy institutes and clinicians with different technical levels. Methods Thirty NPC patients (20 males and 10 females, at a median age of 52 years) with early stage (T1~2N2) and small lymph nodes (≤ 2 cm) admitted in our Army Medical Center of PLA from September 2020 to May 2021 were collected in this study. CTV was delineated according to the International Guideline of CTV Delineation for NPC in 2017, and a deep learning model was trained to obtain AI+CTV model. The model was subsequently tested with manually segmented CTV in 10 NPC cases (7 males and 3 females, at a median age of 54 years) in our medical center and 6 cases (4 males and 2 females, at a median age of 46 years) from the teaching hospitals. Dice similarity coefficient (DSC), Hausdorff distance (HD), average symmetric surface distance (ASSD), maximum symmetric surface distance (MSSD) and relative absolute volume difference (RAVD) were analyzed to evaluate the feasibility and accuracy of AI delineation. Results Our established AI+CTV model obtained quite high accuracy, with an average DSC value of 0.865, and median DSC values of high-risk areas (CTV1) and low-risk areas (CTV2) of 0.886 and 0.842, respectively. The median HD, ASSD, MSSD and RAVD of CTV1 and CTV2 were all quite low, that is, 7.789 and 6.144 mm, 1.683 and 1.467 mm, 20.52 and 14.03 mm, 16.30% and 15.14%, respectively. The results of external verification showed that CTV1 delineation had higher consistency than CTV2. CTV1 of 6 patients and CTV2 of 5 patients were well delineated (DSC value was greater than 0.7) except CTV2-DSC value of 1 case was close to 0.7. Conclusion Our AI+CTV model based on small samples is basically feasible for the clinical application of CTV delineation in NPC patients with early stage (T1~2N2) and small lymph nodes (≤2 cm).
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- 2022
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8. Accelerating Equity: Overcoming the Gender Gap in VC Funding
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Chen, Chuan, Fioretti, Michele, He, Junnan, and Jia, Yanrong
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Economics - General Economics - Abstract
We examine the growing gender gap in venture capital funding, focusing on accelerator programs in the U.S. We collect a unique dataset with detailed information on accelerators and startups. Using a two-stage methodology, we first estimate a matching model between startups and accelerators, and then use its output to analyze the gender gap in post-graduation outcomes through a control function approach. Our results show that female-founded startups face a significant funding disadvantage, primarily due to relocation challenges tied to family obligations. However, larger cohorts and higher-quality accelerators help reduce this gap by offering female founders better networking opportunities and mentorship.
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- 2025
9. RL-based Query Rewriting with Distilled LLM for online E-Commerce Systems
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Nguyen, Duy A., Mohan, Rishi Kesav, Yang, Van, Akash, Pritom Saha, and Chang, Kevin Chen-Chuan
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Computer Science - Information Retrieval - Abstract
Query rewriting (QR) is a critical technique in e-commerce search, addressing the lexical gap between user queries and product descriptions to enhance search performance. Existing QR approaches typically fall into two categories: discriminative models and generative methods leveraging large language models (LLMs). Discriminative models often struggle with natural language understanding and offer limited flexibility in rewriting, while generative LLMs, despite producing high-quality rewrites, face high inference latency and cost in online settings. These limitations force offline deployment, making them vulnerable to issues like information staleness and semantic drift. To overcome these challenges, we propose a novel hybrid pipeline for QR that balances efficiency and effectiveness. Our approach combines offline knowledge distillation to create a lightweight but efficient student model with online reinforcement learning (RL) to refine query rewriting dynamically using real-time feedback. A key innovation is the use of LLMs as simulated human feedback, enabling scalable reward signals and cost-effective evaluation without manual annotations. Experimental results on Amazon ESCI dataset demonstrate significant improvements in query relevance, diversity, and adaptability, as well as positive feedback from the LLM simulation. This work contributes to advancing LLM capabilities for domain-specific applications, offering a robust solution for dynamic and complex e-commerce search environments.
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- 2025
10. Clinical effect and follow-up of laparoscopic radical proximal gastrectomy for upper gastric carcinoma
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Wei Meng, Huang Ya-di, Cao Wei-bo, Zhao Ru-dong, Cheng Ze-wei, Jun Ou Yang, Yan Ze-peng, Chen Chuan-qi, Liang Yi-ze, Sun Dan-ping, and Yu Wen-bin
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upper gastric carcinoma ,laparoscopic radical proximal gastrectomy ,tubular esophagogastric anastomosis ,traditional esophagogastrostomy ,indocyanine green tracer technique ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
ObjectiveTo evaluate the safety and clinical effect of tubular esophagogastric anastomosis in laparoscopic radical proximal gastrectomy.MethodsA retrospective analysis was conducted involving 191 patients who underwent laparoscopic radical proximal gastrectomy in the Department of Gastrointestinal Surgery, Qilu Hospital of Shandong University from January 2017 to October 2020. Patients were divided into tubular esophagogastric anastomosis group (TG group) and traditional esophagogastric anastomosis group (EG group) according to the digestive tract reconstruction. Their intraoperative conditions, perioperative recovery and postoperative follow-up were compared. Patients were also divided into indocyanine green group and non-indocyanine green group according to whether or not indocyanine green tracer technology was used during the operation. Their intraoperative condition and perioperative recovery were compared and analyzed after propensity score matching.ResultsThe operation was successfully completed in all patients. Compared with the EG group, the TG group had less volume of gastric tube drainage, shorter gastric tube drainage time and proton pump inhibitors application time, and lower reuse rate of proton pump inhibitors. However, the TG group had a higher anastomotic stenosis at three months after surgery, as measured using anastomotic width and dysphagia score. Nevertheless, the incidence of reflux esophagitis and postoperative quality of life score in the TG group were lower compared with the EG group at 1st and 2nd year after surgery. In the indocyanine green analysis, the indocyanine green group had significantly shorter total operation time and lymph node dissection time and less intraoperative blood loss compared with the non-indocyanine green group. However, compared with the non-indocyanine green group, more postoperative lymph nodes were obtained in the indocyanine green group.ConclusionLaparoscopic radical proximal gastrectomy is safe and effective treatment option for upper gastric cancer. Tubular esophagogastric anastomosis has more advantages in restoring postoperative gastrointestinal function and reducing reflux, but it has a higher incidence of postoperative anastomotic stenosis compared with traditional esophagogastrostomy. The application of indocyanine green tracer technique in laparoscopic radical proximal gastrectomy has positive significance.
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- 2023
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11. Transcriptomic Changes of Astrocytes in the Brain of Rats with Subacute METH Exposure
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WANG Tao, WU Sai-qun, TAN Xiao-hui, CHEN Chuan-xiang, YUE Xia, WANG Hui-jun, DU Si-hao, and QIAO Dong-fang
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forensic toxicology ,transcriptomics ,methamphetamine ,astrocyte ,differentially expressed genes ,signaling pathway ,Medicine - Abstract
ObjectiveTo study the transcriptomic changes of astrocytes in the brain of rats exposed to methamphetamine (METH) and its possible mechanism in neurotoxicity.MethodsThe rats were intraperitoneally injected with METH (15 mg/kg) every 12 h for 8 times in total to establish the subacute rat model of METH. After the model was successfully established, the striatum was extracted, and astrocytes were separated by the magnetic bead method. Transcriptome sequencing was performed on selected astrocytes, and the differentially expressed genes were analyzed by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis.ResultsA total of 876 differentially expressed genes were obtained by transcriptome sequencing, including 321 up-regulated genes and 555 down-regulated genes. GO analysis revealed that differentially expressed genes were mainly concentrated in cell structure, biological process regulation, extracellular matrix and organelle functions. KEGG pathway enrichment analysis showed that steroids biosynthesis, fatty acid biosynthesis, peroxisome proliferators-activated receptor (PPAR), adenosine 5’-monophosphate-activated protein kinase (AMPK) and other signaling pathways were significantly changed.ConclusionMETH can cause structural changes of astrocytes through multiple targets, among which cellular structure, steroids biosynthesis and fatty acid biosynthesis may play an important role in nerve injury, providing a new idea for forensic identification of METH related death.
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- 2021
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12. Distribution of heat transfer coefficient in the vertical tube of falling film evaporator treating saline wastewater based on micro flow and experimental verification
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Liu Bing, Liu Youle, Chen Chuan, Xue Jianliang, Li Huashan, and Ma Zhun
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convective heat transfer coefficient ,falling film evaporation ,numerical simulation ,saline wastewater ,Environmental technology. Sanitary engineering ,TD1-1066 - Abstract
It is still one of the significant solutions to treat saline wastewater with thermal desalination technology, especially falling film evaporators. To improve the performance of the falling film evaporator, a numerical study on the gas–liquid two-phase flow characteristics of saline wastewater in the vertical pipe was conducted using the VOF model. The results showed that the inlet velocity of the saline wastewater increased under the same operating conditions, resulting in the thickening of the liquid film and the increase of the average convective heat transfer coefficient. Increasing the inlet temperature of the working liquid reduced the temperature difference, which led to a decrease of the average convective heat transfer coefficient. In addition, as the inlet concentration of the working liquid increased, the film flow rate and the average convective heat transfer coefficient first decreased and then increased slightly. The experimental results verified the accuracy of the numerical simulation, and the average error was 9.27%. HIGHLIGHTS The study of fluid microflow combined with heat transfer was proposed.; The distribution of heat transfer coefficient based on numerical simulation.; The distribution of heat transfer coefficient is correctly verified by experiments.; The effects of the various operating parameters on the heat and mass transfer processes are studied.;
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- 2021
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13. Novel H2S donor proglumide-ADT-OH protects HUVECs from ox-LDL-induced injury through NF-κB and JAK/SATA pathway
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Ou Xuelan, Xia Tianqin, Yang Chunyan, Yu Chunlei, Zhang Shipeng, Huang Rong, Chen Chuan, and Zhou Chunyang
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hydrogen sulfide donor ,atherosclerosis ,nf-кb ,jak/stat ,proglumide-(5-(4-hydroxyphenyl)-3h-1,2-dithiole-3-thione) ,Medicine - Abstract
As a gaseous mediator, hydrogen sulfide (H2S) has many physiological effects and pathological effects in atherosclerosis. In recent years, many exogenous H2S donors have been synthesized to study atherosclerosis diseases. In this study, proglumide-(5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione) (P-A) was synthesized as a H2S donor. The protective effect and mechanism of P-A on HUVEC that was injured by ox-LDL were detected. The HUEVCs were affected by 100 μmol/L P-A for 24 h; the release of H2S was the largest. After 100 μmol/L P-A acted on HUVEC damage model for 12 h, the cell proliferation activity was the best. The results showed that P-A can downregulate the expression of p-NF-кBp65 protein and reduce the amount of TNF-α and IL-6 and promote the formation of IL-10 by inhibiting the NF-кB pathway, and also induce the expression of superoxide dismutase (SOD) to protect HUVEC from ox-LDL injury. P-A can also regulate JAK/STAT pathway to reduce the expression of p-JAK2 protein and reduce the production of IL-6 and TNF-α. P-A has protective effect on HUVEC injured by ox-LDL, and the protective mechanism is related to the regulation of JAK/STAT pathway and NF-кB pathway.
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- 2021
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14. Surgery for idiopathic spinal cord herniation in 11 cases: a retrospective analysis
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GAO Hai⁃hao, SHANG Ai⁃jia, LIU Hong⁃yu, CHEN Ling, SUN Zheng⁃hui, CHEN Chuan⁃biao, and TAO Ben⁃zhang
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hernia ,spinal cord ,thoracic vertebrae ,neurosurgical procedures ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Objective To investigate the clinical presentation, diagnosis, operative strategy and prognosis of idiopathic spinal cord herniation (ISCH). Methods and Results Clinical data of 11 ISCH cases with definite spinal cord dysfunction enrolled in Hainan Hospital and the First Medical Center of PLA General Hospital from August 2015 to December 2019 were retrospectively analyzed. The main clinical manifestations were hypesthesia of pain and temperature, while one case had lumbocrural pain and dysuria. Myasthenia or hypomyotonia was seen in 7 cases and hypermyotonia in 4 cases. One case occurred in the cervical spine, 9 cases occurred in the thoracic spine, and one case occurred in the lumbar spine. The mean Japan Orthopedic Association Scores (JOA) was 6.91. MRI demonstrated that the defect was mostly situated in the level of T4-7 vertebral bodies. Amyelotrophy and T2 hyperintense signal at the corresponding level could be detected. All patients were treated with correction of herniated spinal cord and dural defect repair, and the success rate of surgery was 100%. The postoperative clinical symptoms were improved and the postoperative recovery was well. There were no cerebrospinal fluid leakage and intracranial infection. The mean postoperative JOA score was 11.55, which was significantly improved, and the average rate of improvement was 76.44%. The average follow⁃up period for 11 patients without recurrence was 32 months. The preoperative clinical symptoms disappeared in 5 cases, improved significantly in 3 cases, and alleviate in 3 cases. Conclusions The difficulties of the treatment of ISCH are the preoperative diagnosis and the choice of the best surgical procedure. Early definite diagnosis and surgical treatment are helpful for clinical prognosis of patients.
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- 2021
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15. THESAURUS: Contrastive Graph Clustering by Swapping Fused Gromov-Wasserstein Couplings
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Deng, Bowen, Wang, Tong, Fu, Lele, Huang, Sheng, Chen, Chuan, and Zhang, Tao
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Computer Science - Machine Learning - Abstract
Graph node clustering is a fundamental unsupervised task. Existing methods typically train an encoder through selfsupervised learning and then apply K-means to the encoder output. Some methods use this clustering result directly as the final assignment, while others initialize centroids based on this initial clustering and then finetune both the encoder and these learnable centroids. However, due to their reliance on K-means, these methods inherit its drawbacks when the cluster separability of encoder output is low, facing challenges from the Uniform Effect and Cluster Assimilation. We summarize three reasons for the low cluster separability in existing methods: (1) lack of contextual information prevents discrimination between similar nodes from different clusters; (2) training tasks are not sufficiently aligned with the downstream clustering task; (3) the cluster information in the graph structure is not appropriately exploited. To address these issues, we propose conTrastive grapH clustEring by SwApping fUsed gRomov-wasserstein coUplingS (THESAURUS). Our method introduces semantic prototypes to provide contextual information, and employs a cross-view assignment prediction pretext task that aligns well with the downstream clustering task. Additionally, it utilizes Gromov-Wasserstein Optimal Transport (GW-OT) along with the proposed prototype graph to thoroughly exploit cluster information in the graph structure. To adapt to diverse real-world data, THESAURUS updates the prototype graph and the prototype marginal distribution in OT by using momentum. Extensive experiments demonstrate that THESAURUS achieves higher cluster separability than the prior art, effectively mitigating the Uniform Effect and Cluster Assimilation issues, Comment: Accepted by AAAI 2025
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- 2024
16. Toward Ethical Spatial Analysis: Addressing Endogenous Bias Through Visual Analytics
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Chen, Chuan, Luo, Peng, Zhao, Bo, Feng, Yu, and Meng, Liqiu
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Computer Science - Human-Computer Interaction ,Physics - Data Analysis, Statistics and Probability - Abstract
Spatial analysis can generate both exogenous and endogenous biases, which will lead to ethics issues. Exogenous biases arise from external factors or environments and are unrelated to internal operating mechanisms, while endogenous biases stem from internal processes or technologies. Although much attention has been given to exogenous biases, endogenous biases in spatial analysis have been largely overlooked, and a comprehensive methodology for addressing them is yet to be developed. To tackle this challenge, we propose that visual analytics can play a key role in understanding geographic data and improving the interpretation of analytical results. In this study, we conducted a preliminary investigation using various visualization techniques to explore endogenous biases. Our findings demonstrate the potentials of visual analytics to uncover hidden biases and identify associated issues. Additionally, we synthesized these visualization strategies into a framework that approximates a method for detecting endogenous biases. Through this work, we advocate for the integration of visualization at three critical stages of spatial analysis in order to minimize errors, address ethical concerns, and reduce misinterpretations associated with endogenous biases.
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- 2024
17. MemHunter: Automated and Verifiable Memorization Detection at Dataset-scale in LLMs
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Wu, Zhenpeng, Lou, Jian, Zheng, Zibin, and Chen, Chuan
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Computer Science - Cryptography and Security ,Computer Science - Machine Learning - Abstract
Large language models (LLMs) have been shown to memorize and reproduce content from their training data, raising significant privacy concerns, especially with web-scale datasets. Existing methods for detecting memorization are primarily sample-specific, relying on manually crafted or discretely optimized memory-inducing prompts generated on a per-sample basis, which become impractical for dataset-level detection due to the prohibitive computational cost of iterating through all samples. In real-world scenarios, data owners may need to verify whether a susceptible LLM has memorized their dataset, particularly if the LLM may have collected the data from the web without authorization. To address this, we introduce MemHunter, which trains a memory-inducing LLM and employs hypothesis testing to efficiently detect memorization at the dataset level, without requiring sample-specific memory inducing. Experiments on models like Pythia and Llama demonstrate that MemHunter can extract up to 40% more training data than existing methods under constrained time resources and reduce search time by up to 80% when integrated as a plug-in. Crucially, MemHunter is the first method capable of dataset-level memorization detection, providing a critical tool for assessing privacy risks in LLMs powered by large-scale datasets.
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- 2024
18. PRECISE: Pre-training Sequential Recommenders with Collaborative and Semantic Information
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Song, Chonggang, Shen, Chunxu, Gu, Hao, Wu, Yaoming, Yi, Lingling, Wen, Jie, and Chen, Chuan
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Computer Science - Information Retrieval ,Computer Science - Artificial Intelligence - Abstract
Real-world recommendation systems commonly offer diverse content scenarios for users to interact with. Considering the enormous number of users in industrial platforms, it is infeasible to utilize a single unified recommendation model to meet the requirements of all scenarios. Usually, separate recommendation pipelines are established for each distinct scenario. This practice leads to challenges in comprehensively grasping users' interests. Recent research endeavors have been made to tackle this problem by pre-training models to encapsulate the overall interests of users. Traditional pre-trained recommendation models mainly capture user interests by leveraging collaborative signals. Nevertheless, a prevalent drawback of these systems is their incapacity to handle long-tail items and cold-start scenarios. With the recent advent of large language models, there has been a significant increase in research efforts focused on exploiting LLMs to extract semantic information for users and items. However, text-based recommendations highly rely on elaborate feature engineering and frequently fail to capture collaborative similarities. To overcome these limitations, we propose a novel pre-training framework for sequential recommendation, termed PRECISE. This framework combines collaborative signals with semantic information. Moreover, PRECISE employs a learning framework that initially models users' comprehensive interests across all recommendation scenarios and subsequently concentrates on the specific interests of target-scene behaviors. We demonstrate that PRECISE precisely captures the entire range of user interests and effectively transfers them to the target interests. Empirical findings reveal that the PRECISE framework attains outstanding performance on both public and industrial datasets.
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- 2024
19. Universal non-Hermitian transport in disordered systems
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Li, Bo, Chen, Chuan, and Wang, Zhong
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Quantum Physics ,Condensed Matter - Disordered Systems and Neural Networks ,Condensed Matter - Statistical Mechanics ,Physics - Optics - Abstract
In disordered Hermitian systems, localization of energy eigenstates prohibits wave propagation. In non-Hermitian systems, however, wave propagation is possible even when the eigenstates of Hamiltonian are exponentially localized by disorders. We find in this regime that non-Hermitian wave propagation exhibits novel universal scaling behaviors without Hermitian counterpart. Furthermore, our theory demonstrates how the tail of imaginary-part density of states dictates wave propagation in the long-time limit. Specifically, for the three typical classes, namely the Gaussian, the uniform, and the linear imaginary-part density of states, we obtain logarithmically suppressed sub-ballistic transport, and two types of subdiffusion with exponents that depend only on spatial dimensions, respectively. Our work highlights the fundamental differences between Hermitian and non-Hermitian Anderson localization, and uncovers unique universality in non-Hermitian wave propagation., Comment: 5+10 pages,3+2 figures
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- 2024
20. Query Optimization for Parametric Knowledge Refinement in Retrieval-Augmented Large Language Models
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Cong, Youan, Wang, Cheng, Akash, Pritom Saha, and Chang, Kevin Chen-Chuan
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Computer Science - Computation and Language ,Computer Science - Information Retrieval - Abstract
We introduce the Extract-Refine-Retrieve-Read (ERRR) framework, a novel approach designed to bridge the pre-retrieval information gap in Retrieval-Augmented Generation (RAG) systems through query optimization tailored to meet the specific knowledge requirements of Large Language Models (LLMs). Unlike conventional query optimization techniques used in RAG, the ERRR framework begins by extracting parametric knowledge from LLMs, followed by using a specialized query optimizer for refining these queries. This process ensures the retrieval of only the most pertinent information essential for generating accurate responses. Moreover, to enhance flexibility and reduce computational costs, we propose a trainable scheme for our pipeline that utilizes a smaller, tunable model as the query optimizer, which is refined through knowledge distillation from a larger teacher model. Our evaluations on various question-answering (QA) datasets and with different retrieval systems show that ERRR consistently outperforms existing baselines, proving to be a versatile and cost-effective module for improving the utility and accuracy of RAG systems.
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- 2024
21. Anyon polarons as a window into the competing phases of the Kitaev honeycomb model under a Zeeman field
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Chen, Chuan and Villadiego, Inti Sodemann
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Condensed Matter - Strongly Correlated Electrons - Abstract
We compute the spectra of anyon quasiparticles in all three super-selection sectors of the Kitaev model (i.e., visons, fermions and bosons), perturbed by a Zeeman field away from its exactly solvable limit, to gain insights on the competition of its non-abelian spin-liquid with other nearby phases, such as the mysterious intermediate state observed in the antiferromagnetic model. Both for the ferro- and antiferro-magnetic models we find that the fermions and visons become gapless at nearly identical critical Zeeman couplings. In the ferromagnetic model this is consistent with a direct transition into a polarized state. In the anti-ferromagnetic model this implies that previous theories of the intermediate phase viewed as a spin liquid with a different fermion Chern number are inadequate, as they presume that the vison gap does not close. In the antiferromagnetic model we also find that a bosonic quasiparticle becomes gapless at nearly the same critical field as the fermions and visons. This boson carries the quantum numbers of an anti-ferromagnetic order parameter, suggesting that the intermediate phase has spontaneously broken symmetry with this order., Comment: main text: 4 pages and 2 figures. Supplementary: 12 pages and 9 figures
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- 2024
22. ConTReGen: Context-driven Tree-structured Retrieval for Open-domain Long-form Text Generation
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Roy, Kashob Kumar, Akash, Pritom Saha, Chang, Kevin Chen-Chuan, and Popa, Lucian
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Computer Science - Information Retrieval - Abstract
Open-domain long-form text generation requires generating coherent, comprehensive responses that address complex queries with both breadth and depth. This task is challenging due to the need to accurately capture diverse facets of input queries. Existing iterative retrieval-augmented generation (RAG) approaches often struggle to delve deeply into each facet of complex queries and integrate knowledge from various sources effectively. This paper introduces ConTReGen, a novel framework that employs a context-driven, tree-structured retrieval approach to enhance the depth and relevance of retrieved content. ConTReGen integrates a hierarchical, top-down in-depth exploration of query facets with a systematic bottom-up synthesis, ensuring comprehensive coverage and coherent integration of multifaceted information. Extensive experiments on multiple datasets, including LFQA and ODSUM, alongside a newly introduced dataset, ODSUM-WikiHow, demonstrate that ConTReGen outperforms existing state-of-the-art RAG models., Comment: Accepted at EMNLP'24 Findings
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- 2024
23. Enhancing Short-Text Topic Modeling with LLM-Driven Context Expansion and Prefix-Tuned VAEs
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Akash, Pritom Saha and Chang, Kevin Chen-Chuan
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Computer Science - Computation and Language ,Computer Science - Information Retrieval - Abstract
Topic modeling is a powerful technique for uncovering hidden themes within a collection of documents. However, the effectiveness of traditional topic models often relies on sufficient word co-occurrence, which is lacking in short texts. Therefore, existing approaches, whether probabilistic or neural, frequently struggle to extract meaningful patterns from such data, resulting in incoherent topics. To address this challenge, we propose a novel approach that leverages large language models (LLMs) to extend short texts into more detailed sequences before applying topic modeling. To further improve the efficiency and solve the problem of semantic inconsistency from LLM-generated texts, we propose to use prefix tuning to train a smaller language model coupled with a variational autoencoder for short-text topic modeling. Our method significantly improves short-text topic modeling performance, as demonstrated by extensive experiments on real-world datasets with extreme data sparsity, outperforming current state-of-the-art topic models., Comment: EMNLP Findings 2024. arXiv admin note: substantial text overlap with arXiv:2310.15420
- Published
- 2024
24. Study on the Matching of Construction Subcontractor Based on Cooperative Game
- Author
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Chen Chuan, Liu Linlin, and Zhang Xinli
- Subjects
general contractor ,subcontractor ,evolutionary game ,supply chains ,Environmental sciences ,GE1-350 - Abstract
China’s construction industry is the pillar industry of the national economy, but the market competition faced by construction enterprises is becoming increasingly fierce. The general contractor must carry out close business cooperation with other subcontractors and integrate the valuable resources of all parties to cope with the competition jointly. Based on this, this paper constructs the evolutionary game model between the general contractor and the subcontractor. The equilibrium point is calculated by copying the dynamic equation, and the influence of parameters on the evolution probability of both sides is explored. Finally, combined with the numerical simulation, some suggestions on the matching of construction subcontractor suppliers are put forward: improve the cognitive level of the supply chain and reduce the contract cost of the enterprise; adopt an efficient and transparent supervision mechanism to reduce the risk of cooperation; improve the information transmission network of the supply chain and reduce the cost of failure; clear project claims and reward and punishment measures to enhance the enthusiasm of enterprises.
- Published
- 2023
- Full Text
- View/download PDF
25. Computation of Atmospheric Optical Parameters Based on Deep Neural Network and PCA
- Author
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Chen Chuan, Cheng Zheng, Liu Bo, and Li Ligang
- Subjects
Atmospheric optical parameters ,imaging simulation ,deep neural networks ,principal component analysis ,atmospheric downward radiation ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
The effect of the atmosphere on the propagating energy during the remote sensing imaging simulation is one of the most critical factors affecting the quality of image. The classical methods retrieving atmospheric optical parameters (AOP) have shortcomings in GPU-based imaging simulation application. This paper proposed a method based on deep neural networks (DNN) and principal component analysis (PCA) to compute AOP. Firstly, MODTRAN is employed to obtain large numbers of AOP as original spectrum set in different weather and observation geometry conditions. Then the dimension of original spectrum is reduced by PCA. Next, a DNN is constructed and trained using compressed spectral signatures. Finally, estimated AOP are obtained through inverse PCA by decompressing the output of DNN. The results show that original AOP and estimated AOP have a high spectral similarity which relative error is less than 2%. Compared with the classical methods, DNN can be used to accurately and fast compute AOP with any kind of conditions in remote sensing imaging applications, without consuming large of graphic memory.
- Published
- 2020
- Full Text
- View/download PDF
26. Incremental Context-free Grammar Inference in Black Box Settings
- Author
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Li, Feifei, Chen, Xiao, Xiao, Xi, Sun, Xiaoyu, Chen, Chuan, Wang, Shaohua, and Han, Jitao
- Subjects
Computer Science - Programming Languages ,Computer Science - Software Engineering - Abstract
Black-box context-free grammar inference presents a significant challenge in many practical settings due to limited access to example programs. The state-of-the-art methods, Arvada and Treevada, employ heuristic approaches to generalize grammar rules, initiating from flat parse trees and exploring diverse generalization sequences. We have observed that these approaches suffer from low quality and readability, primarily because they process entire example strings, adding to the complexity and substantially slowing down computations. To overcome these limitations, we propose a novel method that segments example strings into smaller units and incrementally infers the grammar. Our approach, named Kedavra, has demonstrated superior grammar quality (enhanced precision and recall), faster runtime, and improved readability through empirical comparison., Comment: Accepted by ASE'24
- Published
- 2024
27. Artificial intelligence algorithms enhance urine cytology reporting confidence in postoperative follow-up for upper urinary tract urothelial carcinoma
- Author
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Chen, Cheng-Che, Yen, Tsung-Han, Li, Jian-Ri, Chen, Chih-Jung, Yang, Chi-Shun, Lai, Jing-Yi, Lin, Shu-Jiuan, Yeh, Cheng-Hung, Hsu, Shih-Wen, Lin, Ming-Yu, Liu, Tien-Jen, and Chen, Chuan Shu
- Published
- 2025
- Full Text
- View/download PDF
28. The Long-Term Functional and Oncologic Outcomes of Kidney-Sparing Surgery in Upper Tract Urothelial Carcinoma
- Author
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Wang, Yu-Chieh, Li, Jian-Ri, Chen, Chuan-Shu, Wang, Shian-Shiang, Yang, Cheng-Kuang, Chiu, Kun-Yuan, and Hsu, Chiann-Yi
- Published
- 2025
- Full Text
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29. Indoxyl Sulfate Induces Ventricular Arrhythmias Attenuated by Secretoneurin in Right Ventricular Outflow Tract Cardiomyocytes
- Author
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Hung, Yuan, Cheng, Chen-Chuan, Lu, Yen-Yu, Huang, Shih-Yu, Chen, Yao-Chang, Lin, Fong-Jhih, Lin, Wei-Shiang, Kao, Yu-Hsun, Lin, Yung-Kuo, Chen, Shih-Ann, and Chen, Yi-Jen
- Published
- 2025
- Full Text
- View/download PDF
30. Analysis of Channel Evolution and Its Influence of Xunwu River in Source Area of Dongjiang River Based on GIS Technology
- Author
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CHEN Chuan and ZENG Jinfeng
- Subjects
GIS ,river channel evolution ,influence analysis ,main stream of Xunwu River ,source area of Dongjiang River ,River, lake, and water-supply engineering (General) ,TC401-506 - Abstract
Based on the measured data of large fixed sections at Shuibei Hydrological Station from 2010 to 2020 and the underwater topographic survey data near Shuibei Hydrological Station,this paper constructs a topographic database of underwater sections and a three-dimensional underwater topographic model near Shuibei Hydrological Station for riverbed change analysis by using GIS technology,analyzes the channel scouring and silting in single Shuibei Station section of the main stream of Xunwu River in terms of temporal and spatial change,and discusses the influencing factors and the influence of the changes.The results show that:GIS technology is an effective method to study the changes of river topography.The average annual river-bed elevation of Shuibei Station section of the main stream of Xunwu River decreased by 0.75 m from 2010 to 2015,and by 0.52 m from 2015 to 2020.With the scouring of the main channel terrain during 2010—2020,the average undercut depth is 1.27 m.The main factors for the topographic change of the river channel in this section are the sand restraining of power plants,the sand mining of river channels and the comprehensive treatment of abandoned mines.The annual undercut of river channels will increase the storage capacity of river channels and increase the reverberation time of pollutants in the downstream channels,thus worsening the water quality.In a worse case,the severe evolution of riverbed may cause the dangerous situation of the bridge across the river and even the hollowing out or collapse of embankment.
- Published
- 2021
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- View/download PDF
31. The Influence of Oil Temperature on the Content of Dissolved Gases in Oil Under Partial Discharge Conditions
- Author
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Gao, Jie, Huang, Meng, Qi, Bo, Deng, Xianqin, Chen, Chuan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Sha, Aimin, editor, Liu, Zhigang, editor, Wang, Xiaojun, editor, Xiao, Qian, editor, Zang, Yiming, editor, and Tang, Longfei, editor
- Published
- 2025
- Full Text
- View/download PDF
32. Non-Ioffe-Larkin composition rule and spinon-dictated electric transport in doped Mott insulators
- Author
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Chen, Chuan, Zhang, Jia-Xin, Song, Zhi-Jian, and Weng, Zheng-Yu
- Subjects
Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Superconductivity - Abstract
The electric resistivity is examined in the constrained Hilbert space of a doped Mott insulator, which is dictated by a non-Ioffe-Larkin composition rule due to the underlying mutual Chern-Simons topological gauge structure. In the low-temperature pseudogap phase, where holons remain condensed while spinons proliferate, the charge transport is governed by a chiral spinon excitation, comprising a bosonic spin-$1/2$ at the core of a supercurrent vortex. It leads to a vanishing resistivity with the "confinement" of the spinons in the superconducting phase but a low-$T$ divergence of the resistivity once the spinon confinement is disrupted by external magnetic fields. In the latter, the chiral spinons will generate a Hall number $n_H =$ doping concentration $\delta$ and a Nernst effect to signal an underlying long-range entanglement between the charge and spin degrees of freedom. Their presence is further reflected in thermodynamic quantities such as specific heat and spin susceptibility. Finally, in the high-temperature spin-disordered phase, it is shown that the holons exhibit a linear-$T$ resistivity by scattering with the spinons acting as free local moments, which generate randomized gauge fluxes as perceived by the charge degree of freedom., Comment: 6+6 pages, 6 figures
- Published
- 2024
33. Mapping AI Ethics Narratives: Evidence from Twitter Discourse Between 2015 and 2022
- Author
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Wei, Mengyi, Zhang, Puzhen, Chen, Chuan, Chen, Dongsheng, Zuo, Chenyu, and Meng, Liqiu
- Subjects
Computer Science - Computers and Society - Abstract
Public participation is indispensable for an insightful understanding of the ethics issues raised by AI technologies. Twitter is selected in this paper to serve as an online public sphere for exploring discourse on AI ethics, facilitating broad and equitable public engagement in the development of AI technology. A research framework is proposed to demonstrate how to transform AI ethics-related discourse on Twitter into coherent and readable narratives. It consists of two parts: 1) combining neural networks with large language models to construct a topic hierarchy that contains popular topics of public concern without ignoring small but important voices, thus allowing a fine-grained exploration of meaningful information. 2) transforming fragmented and difficult-to-understand social media information into coherent and easy-to-read stories through narrative visualization, providing a new perspective for understanding the information in Twitter data. This paper aims to advocate for policy makers to enhance public oversight of AI technologies so as to promote their fair and sustainable development., Comment: 22 pages, 6 figures
- Published
- 2024
34. GI-NAS: Boosting Gradient Inversion Attacks through Adaptive Neural Architecture Search
- Author
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Yu, Wenbo, Fang, Hao, Chen, Bin, Sui, Xiaohang, Chen, Chuan, Wu, Hao, Xia, Shu-Tao, and Xu, Ke
- Subjects
Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Gradient Inversion Attacks invert the transmitted gradients in Federated Learning (FL) systems to reconstruct the sensitive data of local clients and have raised considerable privacy concerns. A majority of gradient inversion methods rely heavily on explicit prior knowledge (e.g., a well pre-trained generative model), which is often unavailable in realistic scenarios. To alleviate this issue, researchers have proposed to leverage the implicit prior knowledge of an over-parameterized network. However, they only utilize a fixed neural architecture for all the attack settings. This would hinder the adaptive use of implicit architectural priors and consequently limit the generalizability. In this paper, we further exploit such implicit prior knowledge by proposing Gradient Inversion via Neural Architecture Search (GI-NAS), which adaptively searches the network and captures the implicit priors behind neural architectures. Extensive experiments verify that our proposed GI-NAS can achieve superior attack performance compared to state-of-the-art gradient inversion methods, even under more practical settings with high-resolution images, large-sized batches, and advanced defense strategies.
- Published
- 2024
35. Impacts of ALP on the Constraints of Dark Photon
- Author
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Chen, Chuan-Ren, Hsieh, Yuan-Feng, and Nugroho, Chrisna Setyo
- Subjects
High Energy Physics - Phenomenology - Abstract
Dark sector may exist and interact with Standard Model (SM) through the $U(1)$ kinetic mixing. Through this portal-type interaction, dark photon from dark sector couples to SM fermions, and may explain the discrepancy between experimental data and SM calculations on muon anomalous magnetic moment, muon $g-2$. However, current searches for dark photon impose stringent constraints on the mixing parameter $\varepsilon$ for various dark photon masses, excluding the favorite parameter space for muon $g-2$. In this paper, we study the case where a global $U(1)$ in dark sector is spontaneously broken, resulting a light pseudo-Goldstone, axion-like particle (ALP) $a$, which couples to dark photon and SM photon, $g_{a\gamma\gamma'}$. Through this interaction, dark photon may decay into photon and ALP when this channel is kinematically allowed. As a result, the experimental constraints on dark photon change significantly, and dark photon is able to explain the muon $g-2$ anomaly when its mass is heavier than $10$ GeV., Comment: 9 pages, 3 figures
- Published
- 2024
36. Fast adiabatic preparation of multi-squeezed states by jumping along the path
- Author
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Chen, Chuan, Lu, Jian-Yu, Chen, Xu-Yang, and Wang, Zhen-Yu
- Subjects
Quantum Physics - Abstract
Multi-squeezed states, also known as generalized squeezed states, are valuable quantum non-Gaussian resources, because they can feature non-classical properties such as large phase-space Wigner negativities. In this work, we introduce a novel shortcuts to adiabaticity (STA) method for the fast preparation of multi-squeezed states. In contrast to previous STA methods, which rely on the use of counterdiabatic control to suppress unwanted non-adiabatic effects, our method simplifies the process and accelerates state preparation by selecting an appropriate sampling along a quantum evolution path. We demonstrate the high-fidelity and fast preparation of multi-squeezed states, as well as hybrid entangled states between a bosonic mode and a qubit.
- Published
- 2024
37. Advances in Robust Federated Learning: Heterogeneity Considerations
- Author
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Chen, Chuan, Liao, Tianchi, Deng, Xiaojun, Wu, Zihou, Huang, Sheng, and Zheng, Zibin
- Subjects
Computer Science - Machine Learning - Abstract
In the field of heterogeneous federated learning (FL), the key challenge is to efficiently and collaboratively train models across multiple clients with different data distributions, model structures, task objectives, computational capabilities, and communication resources. This diversity leads to significant heterogeneity, which increases the complexity of model training. In this paper, we first outline the basic concepts of heterogeneous federated learning and summarize the research challenges in federated learning in terms of five aspects: data, model, task, device, and communication. In addition, we explore how existing state-of-the-art approaches cope with the heterogeneity of federated learning, and categorize and review these approaches at three different levels: data-level, model-level, and architecture-level. Subsequently, the paper extensively discusses privacy-preserving strategies in heterogeneous federated learning environments. Finally, the paper discusses current open issues and directions for future research, aiming to promote the further development of heterogeneous federated learning.
- Published
- 2024
38. Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma.
- Author
-
Visvanathan, Abhirami, Saulnier, Olivier, Chen, Chuan, Haldipur, Parthiv, Orisme, Wilda, Delaidelli, Alberto, Shin, Seungmin, Millman, Jake, Bryant, Andrew, Abeysundara, Namal, Wu, Xujia, Hendrikse, Liam, Patil, Vikas, Bashardanesh, Zahedeh, Golser, Joseph, Livingston, Bryn, Nakashima, Takuma, Funakoshi, Yusuke, Ong, Winnie, Rasnitsyn, Alexandra, Aldinger, Kimberly, Richman, Cory, Van Ommeren, Randy, Lee, John, Ly, Michelle, Vladoiu, Maria, Kharas, Kaitlin, Balin, Polina, Erickson, Anders, Fong, Vernon, Zhang, Jiao, Suárez, Raúl, Wang, Hao, Huang, Ning, Pallota, Jonelle, Douglas, Tajana, Haapasalo, Joonas, Razavi, Ferechte, Silvestri, Evelina, Sirbu, Olga, Worme, Samantha, Kameda-Smith, Michelle, Wu, Xiaochong, Daniels, Craig, MichaelRaj, Antony, Bhaduri, Aparna, Schramek, Daniel, Suzuki, Hiromichi, Garzia, Livia, Ahmed, Nabil, Kleinman, Claudia, Stein, Lincoln, Dirks, Peter, Dunham, Christopher, Jabado, Nada, Rich, Jeremy, Li, Wei, Sorensen, Poul, Wechsler-Reya, Robert, Weiss, William, Millen, Kathleen, Ellison, David, Dimitrov, Dimiter, and Taylor, Michael
- Subjects
brain development ,brain tumor immunotherapy ,cancer genomics ,group 3 medulloblastoma ,perivascular niche ,rhombic lip ,Humans ,Medulloblastoma ,Animals ,Neoplastic Stem Cells ,Mice ,Rhombencephalon ,Cerebellar Neoplasms ,Endothelial Cells ,Stem Cell Niche ,Stem Cells ,Coculture Techniques ,Embryonic Structures ,Metencephalon - Abstract
We identify a population of Protogenin-positive (PRTG+ve) MYChigh NESTINlow stem cells in the four-week-old human embryonic hindbrain that subsequently localizes to the ventricular zone of the rhombic lip (RLVZ). Oncogenic transformation of early Prtg+ve rhombic lip stem cells initiates group 3 medulloblastoma (Gr3-MB)-like tumors. PRTG+ve stem cells grow adjacent to a human-specific interposed vascular plexus in the RLVZ, a phenotype that is recapitulated in Gr3-MB but not in other types of medulloblastoma. Co-culture of Gr3-MB with endothelial cells promotes tumor stem cell growth, with the endothelial cells adopting an immature phenotype. Targeting the PRTGhigh compartment of Gr3-MB in vivo using either the diphtheria toxin system or chimeric antigen receptor T cells constitutes effective therapy. Human Gr3-MBs likely arise from early embryonic RLVZ PRTG+ve stem cells inhabiting a specific perivascular niche. Targeting the PRTGhigh compartment and/or the perivascular niche represents an approach to treat children with Gr3-MB.
- Published
- 2024
39. Absence of PNET formation and normal longevity in a mouse model of Mahvash disease.
- Author
-
Xu, Yingna, Liu, Qiaofeng, Chen, Chuan-Wei, Wang, Qiuying, Du, Tianyuan, Yu, Run, Zhou, Qingtong, Yang, Dehua, and Wang, Ming-Wei
- Subjects
Amino acid ,Glucagon ,Glucagon receptor ,Mahvash disease ,Metabolism - Abstract
Mahvash disease, a rare autosomal recessive metabolic disorder characterized by biallelic loss-of-function mutations in the glucagon receptor gene (GCGR), induces significant pancreatic hyperglucagonemia, resulting in α-cell hyperplasia and occasional hypoglycemia. Utilizing CRISPR-Cas9 technology, we engineered a mouse model, designated as Gcgr V369M/V369M, harboring a homozygous V369M substitution in the glucagon receptor (GCGR). Although wild-type (WT) and Gcgr V369M/V369M mice exhibited no discernible difference in appearance or weight, adult Gcgr V369M/V369M mice, approximately 12 months of age, displayed a notable decrease in fasting blood glucose levels and elevated the levels of cholesterol and low-density lipoprotein-cholesterol. Moreover, plasma amino acid levels such as alanine (Ala), proline (Pro) and arginine (Arg) were elevated in Gcgr V369M/V369M mice contributing to α-cell proliferation and hyperglucagonemia. Despite sustained α-cell hyperplasia and increased circulating glucagon levels in Gcgr V369M/V369M mice, metabolic disparities between the two groups gradually waned with age accompanied by a reduction in α-cell hyperplasia. Throughout the lifespan of the mice (up to approximately 30 months), pancreatic neuroendocrine tumors (PNETs) did not manifest. This prolonged observation of metabolic alterations in Gcgr V369M/V369M mice furnishes valuable insights for a deeper comprehension of mild Mahvash disease in humans.
- Published
- 2024
40. Investigation on the Structure Profile of Precise Copper Tube by Three-Roll Planetary Rolling Based on Finite Element Simulation Assisted by Machine Learning
- Author
-
Liu, Jin-Song, Sun, Yang-Le, Chen, Da-Yong, Song, Hong-Wu, Zhang, Shi-Hong, and Chen, Chuan-Lai
- Published
- 2024
- Full Text
- View/download PDF
41. Dimethylarsinic acid induces rice straighthead disease by causing genotoxicity and abnormal floral development
- Author
-
Yang, Yang, Tang, Zhong, Chen, Chuan, Wang, Peng, and Zhao, Fang-Jie
- Published
- 2024
- Full Text
- View/download PDF
42. Rare $B$ and $K$ decays in a scotogenic model
- Author
-
Chen, Chuan-Hung and Chiang, Cheng-Wei
- Subjects
High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
A scotogenic model can radiatively generate the observed neutrino mass, provide a dark matter candidate, and lead to rare lepton flavor-violating processes. We aim to extend the model to establish a potential connection to the quark flavor-related processes within the framework of scotogenesis, enhancing the unexpectedly large branching ratio (BR) of $B^+\to K^+ \nu \bar\nu$, observed by Belle II Collaboration. Meanwhile, the model can address tensions between some experimental measurements and standard model (SM) predictions in flavor physics, such as the muon $g-2$ excess and the higher BR of $B_s \to \mu^- \mu^+$. We introduce in the model the following dark particles: a neutral singlet Dirac-type lepton ($N$); two inert Higgs doublets ($\eta_{1,2}$), with one of which carrying a lepton number; a charged singlet dark scalar $(\chi^+)$, and a singlet vector-like up-type dark quark ($T$). The first two entities are responsible for the radiative neutrino mass, and $\chi^+$ couples to right-handed quarks and leptons and can resolve the tensions existing in muon $g-2$ and $B_s\to \mu^- \mu^+$. Furthermore, the BR of $B^+ \to K^+ \nu \bar\nu$ can be enhanced up to a factor of 2 compared to the SM prediction through the mediations of the dark $T$ and the charged scalars. In addition, we also study the impacts on the $K\to \pi \nu \bar\nu$ decays., Comment: 34 pages, 6 figures, references added, text revised
- Published
- 2024
43. FedBRB: An Effective Solution to the Small-to-Large Scenario in Device-Heterogeneity Federated Learning
- Author
-
Xu, Ziyue, Xu, Mingfeng, Liao, Tianchi, Zheng, Zibin, and Chen, Chuan
- Subjects
Computer Science - Machine Learning - Abstract
Recently, the success of large models has demonstrated the importance of scaling up model size. This has spurred interest in exploring collaborative training of large-scale models from federated learning perspective. Due to computational constraints, many institutions struggle to train a large-scale model locally. Thus, training a larger global model using only smaller local models has become an important scenario (i.e., the \textbf{small-to-large scenario}). Although recent device-heterogeneity federated learning approaches have started to explore this area, they face limitations in fully covering the parameter space of the global model. In this paper, we propose a method called \textbf{FedBRB} (\underline{B}lock-wise \underline{R}olling and weighted \underline{B}roadcast) based on the block concept. FedBRB can uses small local models to train all blocks of the large global model, and broadcasts the trained parameters to the entire space for faster information interaction. Experiments demonstrate FedBRB yields substantial performance gains, achieving state-of-the-art results in this scenario. Moreover, FedBRB using only minimal local models can even surpass baselines using larger local models.
- Published
- 2024
44. Ego Group Partition: A Novel Framework for Improving Ego Experiments in Social Networks
- Author
-
Deng, Lu, Zhang, JingJing, Wang, Yong, and Chen, Chuan
- Subjects
Computer Science - Social and Information Networks ,Statistics - Applications - Abstract
Estimating the average treatment effect in social networks is challenging due to individuals influencing each other. One approach to address interference is ego cluster experiments, where each cluster consists of a central individual (ego) and its peers (alters). Clusters are randomized, and only the effects on egos are measured. In this work, we propose an improved framework for ego cluster experiments called ego group partition (EGP), which directly generates two groups and an ego sub-population instead of ego clusters. Under specific model assumptions, we propose two ego group partition algorithms. Compared to the original ego clustering algorithm, our algorithms produce more egos, yield smaller biases, and support parallel computation. The performance of our algorithms is validated through simulation and real-world case studies.
- Published
- 2024
45. Unbiased Estimation for Total Treatment Effect Under Interference Using Aggregated Dyadic Data
- Author
-
Deng, Lu, Li, Yilin, Zhang, JingJing, Wang, Yong, and Chen, Chuan
- Subjects
Computer Science - Social and Information Networks ,Statistics - Applications - Abstract
In social media platforms, user behavior is often influenced by interactions with other users, complicating the accurate estimation of causal effects in traditional A/B experiments. This study investigates situations where an individual's outcome can be broken down into the sum of multiple pairwise outcomes, a reflection of user interactions. These outcomes, referred to as dyadic data, are prevalent in many social network contexts. Utilizing a Bernoulli randomized design, we introduce a novel unbiased estimator for the total treatment effect (TTE), which quantifies the difference in population mean when all individuals are assigned to treatment versus control groups. We further explore the bias of our estimator in scenarios where it is impractical to include all individuals in the experiment, a common constraint in online control experiments. Our numerical results reveal that our proposed estimator consistently outperforms some commonly used estimators, underscoring its potential for more precise causal effect estimation in social media environments.
- Published
- 2024
46. Clients Collaborate: Flexible Differentially Private Federated Learning with Guaranteed Improvement of Utility-Privacy Trade-off
- Author
-
Li, Yuecheng, Wang, Tong, Chen, Chuan, Lou, Jian, Chen, Bin, Yang, Lei, and Zheng, Zibin
- Subjects
Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Cryptography and Security - Abstract
To defend against privacy leakage of user data, differential privacy is widely used in federated learning, but it is not free. The addition of noise randomly disrupts the semantic integrity of the model and this disturbance accumulates with increased communication rounds. In this paper, we introduce a novel federated learning framework with rigorous privacy guarantees, named FedCEO, designed to strike a trade-off between model utility and user privacy by letting clients ''Collaborate with Each Other''. Specifically, we perform efficient tensor low-rank proximal optimization on stacked local model parameters at the server, demonstrating its capability to flexibly truncate high-frequency components in spectral space. This implies that our FedCEO can effectively recover the disrupted semantic information by smoothing the global semantic space for different privacy settings and continuous training processes. Moreover, we improve the SOTA utility-privacy trade-off bound by an order of $\sqrt{d}$, where $d$ is the input dimension. We illustrate our theoretical results with experiments on representative image datasets. It observes significant performance improvements and strict privacy guarantees under different privacy settings., Comment: 22 pages, 8 figures
- Published
- 2024
47. Enhanced thermal properties of 3D-laminated laser-induced graphene paper infiltrated epoxy composites
- Author
-
Zhang, Yong, Liu, Weiwei, Guo, Xiaohui, Zhang, Qixin, Zhang, Yan, Chen, Chuan, and Cao, Liqiang
- Published
- 2025
- Full Text
- View/download PDF
48. Effect of Nb Doping on High Temperature Oxidation Resistance of Ti-Al Alloyed Coatings
- Author
-
DAI Jing-jie, ZHANG Feng-yun, WANG A-min, CHEN Chuan-zhong, and WENG Fei
- Subjects
titanium alloy ,Ti-Al alloyed coating ,Nb doping ,high temperature oxidation resistance ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Ti-Al alloyed coatings with different Nb doping contents were fabricated on TC4 titanium alloy by laser surface alloying to improve high temperature oxidation resistance of the alloy. Structures and high temperature oxidation behaviors of the alloyed coatings were analyzed and tested by X-ray diffraction (XRD), scanning electron microscope (SEM), energy dispersive spectrometer (EDS) and box-type resistance furnace. The results show that the alloyed coatings consist of TiAl and Ti3Al, and no niobium compound are formed in Ti-Al-Nb alloyed coatings. The alloyed coatings are uniform and exhibit excellent metallurgical bonding with the substrates. A large amount of surface cracks and a few penetrating cracks are formed in Ti-Al alloyed coating without Nb doping, while no obvious cracks are formed in Ti-Al alloyed coating with Nb doping. The oxidation mass gains of all the alloyed coatings were significantly lower than those of the substrate. The alloyed coatings with Nb doping exhibit more excellent high temperature oxidation resistance due to the beneficial machanism of Nb doping. The mechanism of Nb doping on improving high temperature oxidation resistance of Ti-Al alloyed coatings includes reducing the defect concentration of TiO2, refining oxide grains and promoting the formation of Al2O3.
- Published
- 2017
- Full Text
- View/download PDF
49. Research on Mid-term Review System of PPP Project
- Author
-
Liu Jinchan, Guo Yubo, and Chen Chuan
- Subjects
Environmental sciences ,GE1-350 - Abstract
The mid-term review is a necessary window for the PPP project to move forward objectively, and it is also a tool to adjust the expected goals of all parties to the project. This paper built a mid-term review system for PPP projects based on the whole-of-life cycle, studied the objectives, content and evaluation procedures of the mid-term review of PPP projects, and took the urban and rural water supply and drainage integrated PPP project in Mianzhu city, Sichuan Province as the case for field research and interviews, to verify the feasibility of the review system. The research results have a certain guiding role for the mid-term review of PPP projects.
- Published
- 2021
- Full Text
- View/download PDF
50. Research on Determinants of Inclusiveness of China Rural Infrastructure
- Author
-
Jiang Aichun and Chen Chuan
- Subjects
Environmental sciences ,GE1-350 - Abstract
Since the founding of the theory of inclusive growth, it has been widely researched worldwide. However, most of the researches are more focused on the macro-level measurement, but lack of systematic research on micro-level implementation and viable path. From a micro view prospective, this article studies Chinese rural infrastructure with its influence factors and defining inclusive infrastructure. The literature review will clarify the influencing factors of inclusive infrastructure, as to lay the assessment and policy decision foundation of rural infrastructure.
- Published
- 2021
- Full Text
- View/download PDF
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