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10 results on '"COLAFATI, GIOVANNA S."'

2. Case Report: Remarkable breakthrough: successful treatment of a rare intracranial mesenchymal, FET::CREB fusion-positive tumor treated with patient-tailored multimodal therapy

Author

D’Antonio, Federica, primary, Rossi, Sabrina, additional, Giovannoni, Isabella, additional, Alaggio, Rita, additional, Carai, Andrea, additional, Milano, Giuseppe M., additional, Cacchione, Antonella, additional, Cancellieri, Alessandra, additional, Gessi, Marco, additional, Antonelli, Manila, additional, Colafati, Giovanna S., additional, Megaro, Giacomina, additional, Vennarini, Sabina, additional, and Mastronuzzi, Angela, additional

Published
2023
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3. Operator perceived advantage of virtual surgical rehearsal in pediatric neurosurgical oncology: a preliminary experience

Author

PREMUSELLI, Roberto, primary, D’AMORE, Carmen, additional, BARBA, Matteo, additional, MARASI, Alessandra, additional, DEL BALDO, Giada, additional, DE BENEDICTIS, Alessandro, additional, PICCIRILLI, Eleonora, additional, COLAFATI, Giovanna S., additional, MASTRONUZZI, Angela, additional, MARRAS, Carlo E., additional, and CARAI, Andrea, additional

Published
2023
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4. GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma

Author

Del Bufalo, Francesca, primary, De Angelis, Biagio, additional, Caruana, Ignazio, additional, Del Baldo, Giada, additional, De Ioris, Maria A., additional, Serra, Annalisa, additional, Mastronuzzi, Angela, additional, Cefalo, Maria G., additional, Pagliara, Daria, additional, Amicucci, Matteo, additional, Li Pira, Giuseppina, additional, Leone, Giovanna, additional, Bertaina, Valentina, additional, Sinibaldi, Matilde, additional, Di Cecca, Stefano, additional, Guercio, Marika, additional, Abbaszadeh, Zeinab, additional, Iaffaldano, Laura, additional, Gunetti, Monica, additional, Iacovelli, Stefano, additional, Bugianesi, Rossana, additional, Macchia, Stefania, additional, Algeri, Mattia, additional, Merli, Pietro, additional, Galaverna, Federica, additional, Abbas, Rachid, additional, Garganese, Maria C., additional, Villani, Maria F., additional, Colafati, Giovanna S., additional, Bonetti, Federico, additional, Rabusin, Marco, additional, Perruccio, Katia, additional, Folsi, Veronica, additional, Quintarelli, Concetta, additional, and Locatelli, Franco, additional

Published
2023
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7. Metastatic Group 3 Medulloblastoma in a Patient With Tuberous Sclerosis Complex: Case Description and Molecular Characterization of the Tumor

Author

Moavero, Romina, Folgiero, Valentina, Carai, Andrea, Miele, Evelina, Ferretti, Elisabetta, Po, Agnese, Camassei, Francesca Diomedi, Lepri, Francesca Romana, Vigevano, Federico, Curatolo, Paolo, Valeriani, Massimiliano, Colafati, Giovanna S., Locatelli, Franco, Tornesello, Assunta, and Mastronuzzi, Angela

Published
2016
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9. Metastatic Group 3 Medulloblastoma in a Patient With Tuberous Sclerosis Complex: Case Description and Molecular Characterization of the Tumor

Author

Moavero, Romina, primary, Folgiero, Valentina, additional, Carai, Andrea, additional, Miele, Evelina, additional, Ferretti, Elisabetta, additional, Po, Agnese, additional, Diomedi Camassei, Francesca, additional, Lepri, Francesca Romana, additional, Vigevano, Federico, additional, Curatolo, Paolo, additional, Valeriani, Massimiliano, additional, Colafati, Giovanna S., additional, Locatelli, Franco, additional, Tornesello, Assunta, additional, and Mastronuzzi, Angela, additional

Published
2015
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10. Case Report: Remarkable breakthrough: successful treatment of a rare intracranial mesenchymal, FET::CREB fusion-positive tumor treated with patient-tailored multimodal therapy.

Author

D'Antonio F, Rossi S, Giovannoni I, Alaggio R, Carai A, Milano GM, Cacchione A, Cancellieri A, Gessi M, Antonelli M, Colafati GS, Megaro G, Vennarini S, and Mastronuzzi A

Abstract

Background: Intracranial mesenchymal tumors are a rare type of neoplasm (0.3% of all soft tissue tumors) characterized by a fusion of a FET family gene (usually EWSR1 , rarely FUS ) to CREB family genes ( CREB1, ATF1 , and CREM ) with a slow-growing and favorable prognosis. Mesenchymal tumors are most frequently localized in the subcutaneous tissue (typically in the limbs and hands) of young adults and have rarely been diagnosed in the central nervous system. Surgery is the gold standard treatment; adjuvant radiation therapy and chemotherapy with sarcoma-based regimens have been used in rare cases when complete surgical excision was not recommended. In terms of prognosis, these tumors show a tendency for local relapse. The longest patient outcomes reported in the literature are five years., Case Description: This case describes a 27-year-old woman with unconventional extracranial metastatic sites of myxoid intracranial mesenchymal tumor FET::CREB fusion-positive and high expression of PD-1 (40%) and PD-L1 (30%). Based on clinical, molecular, and histological characteristics, she underwent various local and systemic therapies, including surgery, proton beam therapy, the use of immune checkpoint inhibitors, and chemotherapy. These treatments led to a complete remission of the disease after eight years from tumor diagnosis., Conclusions: Our case sheds light on the importance of precision medicine and tailored therapy to explore new treatment opportunities for rare or unknown tumor entities., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 D’Antonio, Rossi, Giovannoni, Alaggio, Carai, Milano, Cacchione, Cancellieri, Gessi, Antonelli, Colafati, Megaro, Vennarini and Mastronuzzi.)

Published
2023
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