1. Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19
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Andrea Mendizabal, Marcos Guzmán-García, Elisa Rabadán-Pejenaute, Jose D Torres-Peña, Marta Nataya Solís-Marquínez, María Dolores Martín-Escalante, Araceli Pineda-Cantero, Maria Del Pilar Fidalgo-Montero, Francisco Javier Carrasco-Sánchez, Enrique Rodilla, Joaquín Fernandez López-Cuervo, María Esther Guisado-Espartero, Ricardo Gil-Sánchez, Lucy Abella-Vázquez, Ángel Luis Martínez-González, Ricardo Gómez-Huelgas, José Manuel Casas-Rojo, Elizabeth Lorenzo-Hernández, Joaquín Escobar-Sevilla, Julio González-Moraleja, Andrés de la Peña-Fernández, Vicente Giner-Galvañ, Alberto Saura, Ramon Boixeda, Iratxe Jimenez, UCH. Departamento de Medicina y Cirugía, Producción Científica UCH 2020, [Rodilla,E, Saura,A, Jiménez,I, Mendizábal,A] Internal Medicine Department, University Hospital of Sagunto, Universidad Cardenal Herrera-CEU, CEU Universities, Sagunto, Spain. [Pineda-Cantero,A, Lorenzo-Hernández,E, and Gómez-Huelgas,R] Internal Medicine Department, Regional University Hospital of Málaga, Málaga, Spain. [Fidalgo-Montero,MP] Internal Medicine Department, Henares Hospital, Coslada (Madrid), Spain. [Fernandez López-Cuervo,J] Internal Medicine Department, Torrevieja University Hospital, Torrevieja (Alicante), Spain. [Gil-Sánchez,R] Internal Medicine Department, La Fe University Hospital, Valencia, Spain. [Rabadán-Pejenaute,E] Internal Medicine Department, San Pedro Hospital, Logroño (La Rioja), Spain. [Abella-Vázquez,L] Internal Medicine Department, Ntra Sra Candelaria University Hospital, Santa Cruz de Tenerife, Spain. [Giner-Galvañ,V] Internal Medicine Department, Hypertension and Cardiometabolic Risk Unit, San Juan de Alicante University Hospital, Miguel Hernández University, San Juan de Alicante (Alicante), Spain. [Solís-Marquínez,MN] Internal Medicine Department, San Agustin University Hospital, Avilés (Asturias), Spain. [Boixeda,R] Internal Medicine Department, Mataró Hospital, Mataró, Barcelona, Spain. [de la Peña-Fernández,A] Internal Medicine Department, Son Llàtzer University Hospital, Palma de Mallorca, Spain. [Carrasco-Sánchez,FJ] Internal Medicine Department, Juan Ramón Jiménez Hospital, Huelva, Spain. [González-Moraleja,J] Internal Medicine Department, Virgen de la Salud Hospital, Toledo, Spain. [Torres-Peña,JD] Internal Medicine Department, Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain. [Guisado-Espartero,ME] Internal Medicine Department, Infanta Margarita Hospital, Cabra (Córdoba), Spain. [Escobar-Sevilla,J] Internal Medicine Department, Virgen de las Nieves University Hospital, Granada, Spain. [Guzmán-García,M] Internal Medicine Department, San Juan de la Cruz Hospital, Úbeda (Jaén), Spain. [Martín-Escalante,MD] Internal Medicine Department, Costa del Sol Hospital, Marbella (Málaga), Spain. [Martínez-González,AL] Internal Medicine Department, León University Hospital Complex, León, Spain. [Casas-Rojo,JM] Internal Medicine Department, Infanta Cristina University Hospital, Parla (Madrid), Spain.
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Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Cardiovascular Agents::Antihypertensive Agents [Medical Subject Headings] ,Hipertensión ,Multivariate analysis ,Physiology ,lcsh:Medicine ,Disease ,030204 cardiovascular system & hematology ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,0302 clinical medicine ,SARS-CoV-2 (Virus) - Pacientes - Mortalidad ,030212 general & internal medicine ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Cause of Death [Medical Subject Headings] ,Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Vital Statistics::Mortality [Medical Subject Headings] ,Atrial fibrillation ,General Medicine ,Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Comorbidity [Medical Subject Headings] ,humanities ,Population study ,all-cause mortality ,Inhibidores de la enzima convertidora de angiotensina ,Cardiology and Cardiovascular Medicine ,angiotensin-converting enzyme inhibitors (ACEIs) ,medicine.medical_specialty ,angiotensin II receptor blockers (ARBs) ,hypertension ,Infecciones por coronavirus ,Antagonistas de receptores de angiotensina ,COVID-19 (Disease) - Patients - Mortality ,Lower risk ,Article ,Diseases::Cardiovascular Diseases::Vascular Diseases::Hypertension [Medical Subject Headings] ,03 medical and health sciences ,Internal medicine ,Diabetes mellitus ,Hypertension ,Internal Medicine ,medicine ,Risk factor ,COVID-19, all-cause mortality, angiotensin II receptor blockers (ARBs), angiotensin-converting enzyme inhibitors (ACEIs), hypertension ,COVID-19 - Pacientes - Mortalidad ,Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings] ,business.industry ,lcsh:R ,COVID-19 ,medicine.disease ,Comorbidity ,Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings] ,SARS-CoV-2 (Virus) - Patients - Mortality ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Hospital Mortality [Medical Subject Headings] ,Observational study ,business ,Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protease Inhibitors::Angiotensin-Converting Enzyme Inhibitors [Medical Subject Headings] - Abstract
It is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who required hospital admission in 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics of survivors versus non-survivors. The mean age of the study population was 67.5 ±, 16.1 years, 42.6% were women. Overall, 2630 (21.5%) subjects died. The most common comorbidity was hypertension (50.9%) followed by diabetes (19.1%), and atrial fibrillation (11.2%). Multivariate analysis showed that after adjusting for gender (males, OR: 1.5, p = 0.0001), age tertiles (second and third tertiles, OR: 2.0 and 4.7, p = 0.0001), and Charlson Comorbidity Index scores (second and third tertiles, OR: 4.7 and 8.1, p = 0.0001), hypertension was significantly predictive of all-cause mortality when this comorbidity was treated with angiotensin-converting enzyme inhibitors (ACEIs) (OR: 1.6, p = 0.002) or other than renin-angiotensin-aldosterone blockers (OR: 1.3, p = 0.001) or angiotensin II receptor blockers (ARBs) (OR: 1.2, p = 0.035). The preexisting condition of hypertension had an independent prognostic value for all-cause mortality in patients with COVID-19 who required hospitalization. ARBs showed a lower risk of lethality in hypertensive patients than other antihypertensive drugs.
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- 2020