1. Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity
- Author
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Hanna-Mari Takkinen, Iris Erlund, Suvi Ahonen, Outi Vaarala, Mikael Knip, Jorma Toppari, Jorma Ilonen, Sari Niinistö, Suvi M. Virtanen, Riitta Veijola, Clinicum, Mikael Knip / Principal Investigator, Children's Hospital, Lastentautien yksikkö, Diabetes and Obesity Research Program, Research Programs Unit, and HUS Children and Adolescents
- Subjects
Male ,Time Factors ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,CHILDHOOD ,Autoimmunity ,Fatty acid status ,medicine.disease_cause ,SERUM ,Cohort Studies ,COWS MILK CONSUMPTION ,chemistry.chemical_compound ,0302 clinical medicine ,HLA-DQ beta-Chains ,Palmitoleic acid ,030212 general & internal medicine ,Finland ,2. Zero hunger ,chemistry.chemical_classification ,Fatty Acids ,HLA-CONFERRED SUSCEPTIBILITY ,COD-LIVER OIL ,n-3 fatty acids ,3. Good health ,Type 1 diabetes ,Milk ,Treatment Outcome ,Docosahexaenoic acid ,Child, Preschool ,Female ,Risk ,YOUNG-CHILDREN ,medicine.medical_specialty ,Breast milk ,Chromatography, Gas ,Genotype ,030209 endocrinology & metabolism ,Islets of Langerhans ,03 medical and health sciences ,Internal medicine ,Fatty Acids, Omega-3 ,Internal Medicine ,medicine ,Animals ,Humans ,Genetic Predisposition to Disease ,ISLET AUTOIMMUNITY ,DISEASE-ASSOCIATED AUTOANTIBODIES ,Autoantibodies ,Milk, Human ,business.industry ,Insulin ,Infant, Newborn ,Autoantibody ,Infant ,Fatty acid ,medicine.disease ,Diabetes Mellitus, Type 1 ,Endocrinology ,chemistry ,3121 General medicine, internal medicine and other clinical medicine ,Case-Control Studies ,ANTIBODIES ,BETA-CELL AUTOIMMUNITY ,business - Abstract
Aims/hypothesis We investigated the association of early serum fatty acid composition with the risk of type 1 diabetes-associated autoimmunity. Our hypothesis was that fatty acid status during infancy is related to type 1 diabetes-associated autoimmunity and that long-chain n-3 fatty acids, in particular, are associated with decreased risk. Methods We performed a nested case-control analysis within the Finnish Type 1 Diabetes Prediction and Prevention Study birth cohort, carrying HLA-conferred susceptibility to type 1 diabetes (n = 7782). Serum total fatty acid composition was analysed by gas chromatography in 240 infants with islet autoimmunity and 480 control infants at the age of 3 and 6 months. Islet autoimmunity was defined as repeated positivity for islet cell autoantibodies in combination with at least one of three selected autoantibodies. In addition, a subset of 43 infants with primary insulin autoimmunity (i.e. those with insulin autoantibodies as the first autoantibody with no concomitant other autoantibodies) and a control group (n = 86) were analysed. A third endpoint was primary GAD autoimmunity defined as GAD autoantibody appearing as the first antibody without other concomitant autoantibodies (22 infants with GAD autoimmunity; 42 infants in control group). Conditional logistic regression was applied, considering multiple comparisons by false discovery rate
- Published
- 2017
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