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2 results on '"CRC patients"'

1. Laparoscopic resection of right colon cancer-a matched pairs analysis.

Author

Zimmermann, M., Benecke, C., Jung, C., Hoffmann, M., Nolde, J., Schlöricke, E., Bruch, H., Keck, T., and Laubert, T.

Subjects
*COLON cancer treatment, *LAPAROSCOPIC surgery, *CANCER treatment, *ADENOCARCINOMA, *SURGICAL excision, *COLECTOMY, *TREATMENT effectiveness
Abstract

Purpose: Laparoscopy for colorectal cancer resection bares early post-operative advantages and results in equal oncologic long-term outcome. However, data on laparoscopic right hemi-colectomy is scarce. Aim of the present study was to analyze a well selected collective of patients with right-sided colon cancer treated open and laparoscopically with regard to peri-operative and long-term outcome. Methods: We analyzed all patients who underwent right-sided hemi-colectomy for colon cancer between January 1996 and March 2013. Data was extracted from our prospective database. Inclusion criteria were tumor localization in the ascending colon, oncologic resection, histology of an adenocarcinoma, tumors UICC I-III, and R0 resection. Exclusion criteria were multiple malignancies including colon, emergency operation, adenoma or pT0 status, and UICC IV. For the matched pairs approach between patients undergoing laparoscopic (LAP) or open (OPEN) surgery, the parameters age, UICC stage, tumor grading, and sex were applied. Results: A total of 188 patients was included in the analysis with n = 94 in both the LAP and the OPEN group. Some peri-operative results demonstrated advantages for laparoscopy including median return to liquid ( p < 0.0001) and solid diet ( p = 0.008), median length of ICU stay ( p < 0.0001), and median length of hospital stay ( p = 0.022). No significant differences were revealed for complication rates, rates of anastomotic leakage, or 30-day mortality. Lymph node yield was identical. Also, no differences in oncologic long-term outcome were detected. Rates for local recurrence were 4.3 and 2.0 %. Conclusion: This matched pairs analysis verifies peri-operative advantages of laparoscopy explicitly for the sub-group of CRC patients undergoing right-sided hemi-colectomy in comparison to open surgery while demonstrating equivalent oncologic long-term results. [ABSTRACT FROM AUTHOR]

Published
2016
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2. Gene and MicroRNA Expression Are Predictive of Tumor Response in Rectal Adenocarcinoma Patients Treated With Preoperative Chemoradiotherapy

Author

Millino, Caterina, Maretto, Isacco, Pacchioni, Beniamina, Digito, Maura, De Paoli, Antonino, Canzonieri, Vincenzo, D’Angelo, Edoardo, Agostini, Marco, Rizzolio, Flavio, Giordano, Antonio, Barina, Andrea, Rajendran, Senthilkumar, Esposito, Giovanni, Lanfranchi, Gerolamo, Nitti, Donato, Pucciarelli, Salvatore, Millino, Caterina, Maretto, Isacco, Pacchioni, Beniamina, Digito, Maura, De Paoli, Antonino, Canzonieri, Vincenzo, D'Angelo, Edoardo, Agostini, Marco, Rizzolio, Flavio, Giordano, Antonio, Barina, Andrea, Rajendran, Senthilkumar, Esposito, Giovanni, Lanfranchi, Gerolamo, Nitti, Donato, and Pucciarelli, Salvatore

Subjects
Adult, Male, CRC patients, Physiology, Messenger, Clinical Biochemistry, Settore BIO/11 - Biologia Molecolare, Adenocarcinoma, Cohort Studies, MicroRNAs, Neoplasms, Preoperative Care, Cluster Analysis, Humans, RNA, Messenger, Aged, Neoplasm Staging, Neoplastic, Rectal Neoplasms, Gene Expression Profiling, Medicine (all), Female, Gene Ontology, Middle Aged, Reproducibility of Results, Treatment Outcome, Chemoradiotherapy, Gene Expression Regulation, Neoplastic, Cell Biology, MicroRNA, Gene Expression Regulation, RNA, Neoplasm
Abstract

Preoperative chemoradiotherapy (pCRT) followed by surgery is the standard treatment for locally advanced rectal cancer (LARC). However, tumor response to pCRT is not uniform, and there are no effective predictive methods. This study investigated whether specific gene and miRNA expression are associated with tumor response to pCRT. Tissue biopsies were obtained from patients before pCRT and resection. Gene and miRNA expression were analyzed using a one-color microarray technique that compares signatures between responders (R) and non-responders (NR), as measured based on tumor regression grade. Two groups composed of 38 "exploration cohort" and 21 "validation cohort" LARC patients were considered for a total of 32 NR and 27 R patients. In the first cohort, using SAM Two Class analysis, 256 genes and 29 miRNAs that were differentially expressed between the NR and R patients were identified. The anti-correlation analysis showed that the same 8 miRNA interacted with different networks of transcripts. The miR-630 appeared only with the NR patients and was anti-correlated with a single transcript: RAB5B. After PAM, the following eight transcripts were strong predictors of tumor response: TMEM188, ITGA2, NRG, TRAM1, BCL2L13, MYO1B, KLF7, and GTSE1. Using this gene set, an unsupervised cluster analysis was applied to the validation cohort and correctly assigned the patients to the NR or R group with 85.7% accuracy, 90% sensitivity, and 82% specificity. All three parameters reached 100% when both cohorts were considered together. In conclusion, gene and miRNA expression profiles may be helpful for predicting response to pCRT in LARC patients. J. Cell. Physiol. 232: 426-435, 2017. © 2016 Wiley Periodicals, Inc.

Published
2017

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