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1. Cyclosporine A prevents cardiac arrest-induced acute respiratory failure: a post-hoc analysis of the CYRUS trial.

Author

Kreitmann, Louis, Argaud, Laurent, Ovize, Michel, Cour, Martin, For the CYRUS Study Group, Gueugniaud, Pierre-Yves, Zéni, Fabrice, Tchénio, Xavier, Quenot, Jean-Pierre, Beuret, Pascal, Badet, Michel, Chaulier, Kevin, Blanc, Quentin, Vallet, Bénédicte, Gainnier, Marc, Alasan, Emel, Sadoune, Sonia, Bobbia, Xavier, and CYRUS Study Group

Subjects
POSITIVE end-expiratory pressure, ADULT respiratory distress syndrome, CYCLOSPORINE
Abstract

The CYRUS trial failed to demonstrate a significant decrease in the sequential organ failure assessment (SOFA) score at 24 h after nonshockable OHCA in patients receiving a prehospital single injection of 2.5 mg/kg CsA [[4]]. Even though this post-hoc analysis of the CYRUS trial does not provide mechanistic insight, our findings are in line with both experimental and clinical studies reporting potent protective effects of CsA against ischemia/reperfusion (I/R) injury [[1], [3], [5]]. [Extracted from the article]

Published
2020
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