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665 results on '"Cabral, Joaquim M. S."'

3. Human Pluripotent Stem Cells: Applications and Challenges for Regenerative Medicine and Disease Modeling

Author

Miranda, Cláudia C., Fernandes, Tiago G., Diogo, M. Margarida, Cabral, Joaquim M. S., Scheper, T., Series editor, Belkin, S., Editorial board member, Bley, T., Editorial board member, Bohlmann, J., Editorial board member, Gu, M. B., Editorial board member, Hu, W.-S., Editorial board member, Mattiasson, B., Editorial board member, Seitz, H., Editorial board member, Ulber, R., Editorial board member, Zeng, A.-P., Editorial board member, Zhong, J.-J., Editorial board member, Zhou, W., Editorial board member, Silva, Ana Catarina, editor, Moreira, João Nuno, editor, Lobo, José Manuel Sousa, editor, Almeida, Hugo, editor, Abreu, T. R., With Contri. By, Almeida, H., With Contri. By, Baran, E. T., With Contri. By, Battaglia, L. S., With Contri. By, Cabral, J. M. S., With Contri. By, Chao, S., With Contri. By, Costa, C. P., With Contri. By, da Silva, C. L., With Contri. By, de Almeida Fuzeta, M., With Contri. By, de Matos Branco, A. D., With Contri. By, del Pozo-Rodríguez, A., With Contri. By, Diogo, M. M., With Contri. By, Fernandes, T. G., With Contri. By, Fernandes-Platzgummer, A., With Contri. By, Gómez-Aguado, I., With Contri. By, Goncalves, J., With Contri. By, Gonçalves, J., With Contri. By, Ladisch, M. R., With Contri. By, Lobo, J. M. S., With Contri. By, Manuel, A. M., With Contri. By, Mao, H. H., With Contri. By, Ministro, J., With Contri. By, Miranda, C. C., With Contri. By, Moreira, J. N., With Contri. By, Ribeiro, R., With Contri. By, Rodríguez-Castejón, J., With Contri. By, Rodríguez-Gascón, A., With Contri. By, Rudge, S. R., With Contri. By, Silva, A. C., With Contri. By, Singh, D. B., With Contri. By, Solinís, M. Á., With Contri. By, Tahmasebifar, A., With Contri. By, Vicente-Pascual, M., With Contri. By, and Yilmaz, B., With Contri. By

Published
2020
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4. Addressing the Manufacturing Challenges of Cell-Based Therapies

Author

de Almeida Fuzeta, Miguel, de Matos Branco, André Dargen, Fernandes-Platzgummer, Ana, da Silva, Cláudia Lobato, Cabral, Joaquim M. S., Scheper, T., Series editor, Belkin, S., Editorial board member, Bley, T., Editorial board member, Bohlmann, J., Editorial board member, Gu, M. B., Editorial board member, Hu, W.-S., Editorial board member, Mattiasson, B., Editorial board member, Seitz, H., Editorial board member, Ulber, R., Editorial board member, Zeng, A.-P., Editorial board member, Zhong, J.-J., Editorial board member, Zhou, W., Editorial board member, Silva, Ana Catarina, editor, Moreira, João Nuno, editor, Lobo, José Manuel Sousa, editor, Almeida, Hugo, editor, Abreu, T. R., With Contri. By, Almeida, H., With Contri. By, Baran, E. T., With Contri. By, Battaglia, L. S., With Contri. By, Cabral, J. M. S., With Contri. By, Chao, S., With Contri. By, Costa, C. P., With Contri. By, da Silva, C. L., With Contri. By, de Almeida Fuzeta, M., With Contri. By, de Matos Branco, A. D., With Contri. By, del Pozo-Rodríguez, A., With Contri. By, Diogo, M. M., With Contri. By, Fernandes, T. G., With Contri. By, Fernandes-Platzgummer, A., With Contri. By, Gómez-Aguado, I., With Contri. By, Goncalves, J., With Contri. By, Gonçalves, J., With Contri. By, Ladisch, M. R., With Contri. By, Lobo, J. M. S., With Contri. By, Manuel, A. M., With Contri. By, Mao, H. H., With Contri. By, Ministro, J., With Contri. By, Miranda, C. C., With Contri. By, Moreira, J. N., With Contri. By, Ribeiro, R., With Contri. By, Rodríguez-Castejón, J., With Contri. By, Rodríguez-Gascón, A., With Contri. By, Rudge, S. R., With Contri. By, Silva, A. C., With Contri. By, Singh, D. B., With Contri. By, Solinís, M. Á., With Contri. By, Tahmasebifar, A., With Contri. By, Vicente-Pascual, M., With Contri. By, and Yilmaz, B., With Contri. By

Published
2020
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7. Synergy between 3D-extruded electroconductive scaffolds and electrical stimulation to improve bone tissue engineering strategies

Author

Silva, João C., primary, Marcelino, Pedro, additional, Meneses, João, additional, Barbosa, Frederico, additional, Moura, Carla S., additional, Marques, Ana C., additional, Cabral, Joaquim M. S., additional, Pascoal-Faria, Paula, additional, Alves, Nuno, additional, Morgado, Jorge, additional, Ferreira, Frederico Castelo, additional, and Garrudo, Fábio F. F., additional

Published
2024
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15. A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

Author

Jalili-Firoozinezhad, Sasan, Gazzaniga, Francesca S., Calamari, Elizabeth L., Camacho, Diogo M., Fadel, Cicely W., Bein, Amir, Swenor, Ben, Nestor, Bret, Cronce, Michael J., Tovaglieri, Alessio, Levy, Oren, Gregory, Katherine E., Breault, David T., Cabral, Joaquim M. S., Kasper, Dennis L., Novak, Richard, and Ingber, Donald E.

Published
2019
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19. Continuous Production of Highly Functional Vascularized Hepatobiliary Organoids from Human Pluripotent Stem Cells using a Scalable Microfluidic Platform

Author

Abbasalizadeh, Saeed, primary, Babaee, Sahab, additional, Kowsari‐Esfahan, Reza, additional, Mazidi, Zahra, additional, Shi, Yichao, additional, Wainer, Jake, additional, Cabral, Joaquim M. S., additional, Langer, Robert, additional, Traverso, Giovanni, additional, and Baharvand, Hossein, additional

Published
2023
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33. Hypothermic Preservation of Adipose-Derived Mesenchymal Stromal Cells as a Viable Solution for the Storage and Distribution of Cell Therapy Products

Author

Branco, André, primary, Tiago, Ana L., additional, Laranjeira, Paula, additional, Carreira, Maria C., additional, Milhano, João C., additional, dos Santos, Francisco, additional, Cabral, Joaquim M. S., additional, Paiva, Artur, additional, da Silva, Cláudia L., additional, and Fernandes-Platzgummer, Ana, additional

Published
2022
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39. Optimized operation of a controlled stirred tank reactor system for the production of mesenchymal stromal cells and their extracellular vesicles.

Author

Fernandes‐Platzgummer, Ana, Cunha, Raquel, Morini, Sara, Carvalho, Marta, Moreno‐Cid, Juan, García, Carmen, Cabral, Joaquim M. S., and da Silva, Cláudia L.

Abstract

The therapeutic effects of human mesenchymal stromal cells (MSC) have been attributed mostly to their paracrine activity, exerted through small‐secreted extracellular vesicles (EVs) rather than their engraftment into injured tissues. Currently, the production of MSC‐derived EVs (MSC‐EVs) is performed in laborious static culture systems with limited manufacturing capacity using serum‐containing media. In this work, a serum‐/xenogeneic‐free microcarrier‐based culture system was successfully established for bone marrow‐derived MSC cultivation and MSC‐EV production using a 2 l‐scale controlled stirred tank reactor (STR) operated under fed‐batch (FB) or fed‐batch combined with continuous perfusion (FB/CP). Overall, maximal cell numbers of (3.0 ± 0.12) × 108 and (5.3 ± 0.32) × 108 were attained at Days 8 and 12 for FB and FB/CP cultures, respectively, and MSC(M) expanded under both conditions retained their immunophenotype. MSC‐EVs were identified in the conditioned medium collected from all STR cultures by transmission electron microscopy, and EV protein markers were successfully identified by Western blot analysis. Overall, no significant differences were observed between EVs isolated from MSC expanded in STR operated under the two feeding approaches. EV mean sizes of 163 ± 5.27 nm and 162 ± 4.44 nm (p > 0.05) and concentrations of (2.4 ± 0.35) × 1011 EVs/mL and (3.0 ± 0.48) × 1011 EVs/mL (p > 0.05) were estimated by nanoparticle tracking analysis for FB and FB/CP cultures, respectively. The STR‐based platform optimized herein represents a major contribution toward the development of human MSC‐ and MSC‐EV‐based products as promising therapeutic agents for Regenerative Medicine settings. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Membrane-Assisted Extractive Bioconversions

Author

Fernandes, Pedro, Prazeres, Duarte M. F., Cabral, Joaquim M. S., Scheper, T., editor, Babel, W., editor, Blanch, H. W., editor, Endo, I., editor, Enfors, S.-O., editor, Fiechter, A., editor, Hoare, M., editor, Mattiasson, B., editor, Sahm, H., editor, Schügerl, K., editor, Stephanopoulos, G., editor, Tsao, D. T., editor, Villadsen, J., editor, Wandrey, C., editor, Zhong, J.-J., editor, von Stockar, Urs., editor, van der Wielen, L. A. M., editor, Bruggink, A., editor, Cabral, J. M. S., editor, Fernandes, P., editor, Jenne, M., editor, Mauch, K., editor, Prazeres, D. M. F., editor, Reuss, M., editor, Schmalzriedt, S., editor, Stark, D., editor, von Stockar, U., editor, and Straathof, A. J. J., editor

Published
2003
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46. Enhanced Proliferative and Osteogenic Potential of Periodontal Ligament Stromal Cells.

Author

Alves, Laura, Machado, Vanessa, Botelho, João, Mendes, José João, Cabral, Joaquim M. S., da Silva, Cláudia L., and Carvalho, Marta S.

Subjects
PERIODONTAL ligament, STROMAL cells, OSTEOINDUCTION, ADIPOSE tissues, THIRD molars, IMPACTION of teeth, ADIPOGENESIS
Abstract

Cell-based therapies using periodontal ligament stromal cells (PDLSC) for periodontal regeneration may represent an alternative source for mesenchymal stromal cells (MSC) to MSC derived from bone marrow (MSC(M)) and adipose tissue (MSC(AT)). We aimed to characterize the osteogenic/periodontal potential of PDLSC in comparison to MSC(M) and MSC(AT). PDLSC were obtained from surgically extracted healthy human third molars, while MSC(M) and MSC(AT) were obtained from a previously established cell bank. Flow cytometry, immunocytochemistry, and cell proliferation analyses provided cellular characteristics from each group. Cells from the three groups presented MSC-like morphology, MSC-related marker expression, and multilineage differentiation capacity (adipogenic, chondrogenic, and osteogenic). In this study, PDLSC expressed osteopontin, osteocalcin, and asporin, while MSC(M) and MSC(AT) did not. Of note, only PDLSC expressed CD146, a marker previously applied to identify PDLSC, and presented higher proliferative potential compared to MSC(M) and MSC(AT). Upon osteogenic induction, PDLSC exhibited higher calcium content and enhanced upregulation of osteogenic/periodontal genes compared to MSC(M) and MSC(AT), such as Runx2, Col1A1 and CEMP-1. However, the alkaline phosphatase activity of PDLSC did not increase. Our findings suggest that PDLSC might be a promising cell source for periodontal regeneration, presenting enhanced proliferative and osteogenic potential compared to MSC(M) and MSC(AT). [ABSTRACT FROM AUTHOR]

Published
2023
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