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2. Tolerability and Effectiveness of Regorafenib Treatment in Patients with Unresectable Hepatocellular Carcinoma: Real-World Data from the United States

Author

Finn RS, Iyer R, Kalman RS, Parikh ND, Cabrera R, Babajanyan S, and Kaseb AO

Subjects
hepatocellular carcinoma, regorafenib, sorafenib, observational study, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Richard S Finn,1 Renuka Iyer,2 Richard S Kalman,3 Neehar D Parikh,4 Roniel Cabrera,5 Svetlana Babajanyan,6 Ahmed O Kaseb7 1Department of Medicine, University of California, Los Angeles, CA, USA; 2Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA; 3Department of Medicine, Einstein Medical Center, Philadelphia, PA, USA; 4Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA; 5Department of Medicine, University of Florida Health, Gainesville, FL, USA; 6US Medical Affairs, Oncology, Bayer Healthcare, Whippany, NJ, USA; 7Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence: Richard S Finn, Department of Medicine, University of California, Los Angeles, CA, USA, Tel +1-310-586-2091, Email rfinn@mednet.ucla.eduIntroduction: While several systemic therapies are available for unresectable hepatocellular carcinoma (uHCC), there is a lack of granular real-world evidence to support the efficacy and safety of these therapies. The REFINE study evaluated safety and effectiveness of regorafenib in a global population under real-world practice conditions. This sub-analysis describes the safety and effectiveness of regorafenib among the United States (US) subset of patients in the REFINE study relative to patients in the non-US subset.Materials and Methods: REFINE was an international, prospective, multicenter observational study. Eligible patients were those with uHCC for whom a decision to treat with regorafenib had already been made. The primary study endpoint was the frequency of documented treatment-emergent adverse events (TEAEs). Additional endpoints included overall survival and progression-free survival. Groups were compared descriptively.Results: Of 1005 patients, 65 were from the US and 940 were from other countries. 91% of patients in the US subset (n=59) and 92% in the non-US subset (n=862) experienced ≥ 1 TEAE. Common adverse events (AEs) included gastrointestinal disorders, fatigue, and hand-foot skin reaction. Median overall survival for patients in the US subset was 11.4 months (interquartile range [IQR]: 4.7– 25.4) and 13.2 months (IQR: 5.8– 26.3) in the non-US subset. Median progression-free survival was 3.4 months (IQR: 2.4– 6.1) for patients in the US subset and 3.9 months (IQR: 2.2– 8.5) in the non-US subset.Conclusion: Regorafenib was associated with similar safety and effectiveness outcomes for patients in the US and non-US subsets of the REFINE study. Differences in the incidence of certain AEs may be due to differences in treatment management between study sites or baseline disease status. These findings are consistent with the phase 3 RESORCE trial and corroborate the safety and effectiveness of regorafenib as a subsequent-line treatment in US patients with uHCC.Keywords: hepatocellular carcinoma, regorafenib, sorafenib, observational study

Published
2025

3. Effectiveness of the Zero Surgical Infection Project (ZSIP) in Spanish hospitals 2017–2021: a prospective cohort study

Author

Nogueras, R.M., Compañ, S.O., García Palacios, M.V., Cachinero, C.M., García de la Vega, M., Andújar, A.C., Hernández Navarrete, M.J., Blazquez, S.C., Duarte, J.M., Prada, M.F., Ortega, C.M., Matas, F.A., Fernández, Y.P., Monserrat Blasco, M.T., Moya García, I.M., Orozco, R.G., Fernández, M.L., Sanz Salanova, J.A., Rodrigo, H.R., Masip, J.M., Domínguez, L.P., Jiménez, M.A., Abad, I.G., Álvarez, A.R., Ramírez, Y.G., Quintana, C.P., Gómez García, J.M., Brugger, M.B., Armijo, D.J., Galán, M.del M.D., Bayle, C.M., Soza, C.R., Miguel, J.M., Hernández, M.G., Martínez, N.T., Fernández, M.C., Steinbauer, C.G., Morel, H.M., Román, V.G., Laguardia, A.M., Valentí, P.G., Payá, J.S., Franco, E.C., Monterde, R.B., Gea Velázquez de Castro, M.T., Pérez, A.V., López Poma, J.C., Vicente de Vera, B.N., Alfonso Sánchez, J.L., Valencia, M.C., Torregrosa, G.P., Cantero, A.T., Aguilá, M.S., Monteagudo Pérez, J.F., Quintero, A.C., Pajares, F.G., Rentero, D.B., Delgado, M.B., Cuenca Giner, M.Á., Vicente de Vera, H.N., León Espinosa, I.F., Flor, P.M., Martínez, S.F., Garrido, J.B., Rius Muñoz, M.A., Sanchiz, P.S., Collado, A.B., Blesa Algas, M.T., Martos, N.M., Luciano, E., Santillana, M.G., Caballero Martínez, M.V., Paternina, G.P., Juárez, A.G., Sánchez, G.P., González Jiménez, M.Á., Guerrero, J.G., Moriñigo, H.M., Haro Pérez, A.M., de la Hoz González, C., González Pérez, M.E., Fernández, A.Q., Garcia Crespo, J.A., Quintana, G.F., Belzunce, A.del V., Espinilla, V.F., Montes Villameriel, F.J., Martínez Sáez, M.S., Domingo, E.P., García Palomar, M.I., García, I.A., Callejo, E.J., Salgado, A.S., Arcal, D.G., Encinas, S.T., Conde, J.M., Pereira Rodríguez, M.J., Meijide, M.S., Rodela, A.R., Gallardo, I.S., Fernández, B.I., Grima, F.G., Valderas X, S., Herreros, F.J., Martínez, A.S., Pérez Romero, S.B., Campayo Rojas, F.J., Uruena Tincani, E.M., Barrachina, R.L., Coro, I.E., Camazón, J.C., Hualde, A.B., Torres Fernández-Gil, M.A., Diego, P.G., Jiménez Buñuales, M.T., Blasco, C.B., Carrandi Camiña, M.B., García, M.V., Páez, D.D., Adham, A.A., Vicente, I.L., Cotera, A.M., Martín, H.G., Torrontegui, U.L., Cogollo, R.R., Navarro-Gracia, J.F., Gómez-Romero, F.J., Lozano-García, F.J., Ortí-Lucas, R., Delgado-De los Reyes, J.A., Fernández-Prada, M., and Herruzo-Cabrera, R.

Published
2025
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4. Functional Analysis of BRCA1 3’UTR Variants Predisposing to Breast Cancer

Author

Sierra-Díaz DC, Cabrera R, Gonzalez-Vasquez LA, Angulo-Aguado M, Llinás-Caballero K, Fonseca-Mendoza DJ, Contreras-Bravo NC, Restrepo CM, Ortega-Recalde O, and Morel A

Subjects
mirna, 3’utr variant, breast cancer, brca1, Medicine (General), R5-920, Genetics, QH426-470
Abstract

Diana Carolina Sierra-Díaz,1 Rodrigo Cabrera,1,2 Laura Alejandra Gonzalez-Vasquez,1 Mariana Angulo-Aguado,1,3 Kevin Llinás-Caballero,1,4 Dora Janeth Fonseca-Mendoza,1 Nora Constanza Contreras-Bravo,1 Carlos Martin Restrepo,1 Oscar Ortega-Recalde,1,5 Adrien Morel1 1Center for Research in Genetics and Genomics (CIGGUR), Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad Del Rosario, Bogotá, Colombia; 2Laboratorio de Biología Molecular y Pruebas Diagnósticas de Alta Complejidad, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia; 3Growth Factors, Nutrients and Cancer Group, Molecular Oncology Programme, Centro Nacional Investigaciones Oncológicas (CNIO), Madrid, Spain; 4Institute for Immunological Research, University of Cartagena, Cartagena, Colombia; 5Departamento de Morfología, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C, ColombiaCorrespondence: Adrien Morel, School of Medicine and Health Sciences, Center for Research in Genetics and Genomics (CIGGUR), Institute of Translational Medicine (IMT), Universidad Del Rosario, Cra 24# 63c - 69, Bogotá, 111221, Colombia, Tel +57-6012970200, Email adrien.morel@urosario.edu.coPurpose: Breast Cancer (BC) is the main female cancer diagnosed worldwide, and it has been described that few genes, such as BRCA1, have a high penetrance for this type of cancer. In this manuscript, we were interested in evaluating the effect of 3’UTR variants on BRCA1 expression.Patients and Methods: To accomplish this objective, Whole Exome Sequencing (WES) data of 400 patients with unselected BC was used to filter variants located in the region of interest of BRCA1 gene, finding two of them (c.*36C>G and c.*369_373del). miRGate and miRanda in silico tools were used to predict microRNA (miRNA) interaction.Results: The two variants (c.*36C>G, c.*369_373del) were predicted to affect miRNA interaction. After cloning of BRCA1 3’UTR into pMIR-Report vector, the construct was transfected into two BC cell lines (MDA-MB-231 and MCF-7), and the variant c.*36C>G evidenced overexpression of reporter gene luciferase, showing that the transcript was not being degraded by the miRNA in MDA-MB-231 cells.Conclusion: The variant seems to protect against Triple Negative BC probably due to the expression level of miRNA in this particular cell line (MDA-MB-231). This is consistent with the clinical history of the patients who harbor BC Hormone Receptors positive (HR+).Keywords: miRNA, 3’UTR variant, breast cancer, BRCA1

Published
2024

5. Experience With Bexarotene to Treat Cutaneous T-Cell Lymphomas: A Study of the Spanish Working Group of Cutaneous Lymphomas

Author

Izu-Belloso, R., Gainza-Apraiz, I., Ortiz-Romero, P., Servitje-Bedate, O., Fernández de Misa-Cabrera, R., Peñate, Y., Hernandez-Machin, B., Estrach-Panella, T., Llamas-Velasco, M., Yanguas-Bayona, J.I., Morillo-Andujar, M., Acebo-Mariñas, E., Perez-Gala, S., Armario-Hita, J.C., Sanchez-Sambucety, P., Ortiz-Brugues, A., Eguren-Michelena, C., Bielsa-Marsol, I., Lopez-Pestaña, A., Blanes-Martinez, M., Fernandez-Guarino, M., and Lopez-Lerma, I.

Published
2024
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6. [Artículo traducido] Experiencia con bexaroteno en linfoma cutáneo de células T: un estudio del Grupo Español de Linfomas Cutáneos (GELC)

Author

Izu-Belloso, R., Gainza-Apraiz, I., Ortiz-Romero, P., Servitje-Bedate, O., Fernández de Misa-Cabrera, R., Peñate, Y., Hernandez-Machin, B., Estrach-Panella, T., Llamas-Velasco, M., Yanguas-Bayona, J.I., Morillo-Andujar, M., Acebo-Mariñas, E., Perez-Gala, S., Armario-Hita, J.C., Sanchez-Sambucety, P., Ortiz-Brugues, A., Eguren-Michelena, C., Bielsa-Marsol, I., Lopez-Pestaña, A., Blanes-Martinez, M., Fernandez-Guarino, M., and Lopez-Lerma, I.

Published
2024
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7. Explicit volume-preserving numerical schemes for relativistic trajectories and spin dynamics

Author

Cabrera, R., Campos, A. G., Bondar, D. I., MacLean, S., and Fillion-Gourdeau, F.

Subjects
Physics - Computational Physics, Physics - Plasma Physics
Abstract

A class of explicit numerical schemes is developed to solve for the relativistic dynamics and spin of particles in electromagnetic fields, using the Lorentz-BMT equation formulated in the Clifford algebra representation of Baylis. It is demonstrated that these numerical methods, reminiscent of the leapfrog and Verlet methods, share a number of important properties: they are energy-conserving, volume-conserving and second order convergent. These properties are analysed empirically by benchmarking against known analytical solutions in constant uniform electrodynamic fields. It is demonstrated that the numerical error in a constant magnetic field remains bounded for long time simulations in contrast to the Boris pusher, whose angular error increases linearly with time. Finally, the intricate spin dynamics of a particle is investigated in a plane wave field configuration., Comment: 15 pages, 9 figures

Published
2020
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8. [Translated article] Cost of Treating Cutaneous T-Cell Lymphoma in Spain: Analysis of MICADOS Study Data by Disease Stage

Author

Navarro Matilla, B., Ortiz Romero, P.L., Pujol Vallverdú, R.M., Combalia Escudero, A., Zapata Paz, I., González Barca, E., Muniesa Montserrat, C., Morillo Andújar, M., Pérez Ferriols, A., Román Curto, C., Fernández de Misa Cabrera, R., Hospital Gil, M., Marín Niebla, A., Rios Rull, P.J., de la Cruz Vicente, F., Izu Belloso, R.M., Martín García-Sancho, A., Parera Amer, M.E., Córdoba Mascuñano, R., Ramón Quiles, M.D., Saus Carreres, A., del Campo García, R., Machan, S., Viguera Ester, P., and Blanco Garnelo, J.

Published
2024
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9. Evaluación de los costes asociados a la enfermedad de pacientes con linfoma cutáneo de células T en España: análisis en función del estadio clínico (estudio MICADOS)

Author

Navarro Matilla, B., Ortiz Romero, P.L., Pujol Vallverdú, R.M., Combalia Escudero, A., Zapata Paz, I., González Barca, E., Muniesa Montserrat, C., Morillo Andújar, M., Pérez Ferriols, A., Román Curto, C., Fernández de Misa Cabrera, R., Hospital Gil, M., Marín Niebla, A., Rios Rull, P.J., de la Cruz Vicente, F., Izu Belloso, R.M., Martín García-Sancho, A., Parera Amer, M.E., Córdoba Mascuñano, R., Ramón Quiles, M.D., Saus Carreres, A., del Campo García, R., Machan, S., Viguera Ester, P., and Blanco Garnelo, J.

Published
2024
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10. Effects of Clinical and Tumor Characteristics on Survival in Patients with Hepatocellular Carcinoma with Bone Metastasis

Author

Ozer M, Goksu SY, Lin RY, Ayasun R, Kahramangil D, Rogers SC, Fabregas JC, Ramnaraign BH, George TJ, Feely M, Cabrera R, Duarte S, Zarrinpar A, and Sahin I

Subjects
hepatocellular carcinoma, hcc, bone metastasis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Muhammet Ozer,1 Suleyman Yasin Goksu,2 Rick Y Lin,3 Ruveyda Ayasun,4 Doga Kahramangil,5 Sherise C Rogers,5,6 Jesus C Fabregas,5,6 Brian H Ramnaraign,5,6 Thomas J George,5,6 Michael Feely,7 Roniel Cabrera,8 Sergio Duarte,9 Ali Zarrinpar,9 Ilyas Sahin5,6 1Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; 2Division of Hematology/Oncology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; 3Department of Medicine, University of Florida Health Cancer Center, Gainesville, FL, USA; 4Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA; 5Division of Hematology/Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA; 6University of Florida Health Cancer Center, Gainesville, FL, USA; 7Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA; 8Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL, USA; 9Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, USACorrespondence: Ilyas Sahin, Department of Medicine, University of Florida, Gainesville, FL, 32608, USA, Email i.sahin@ufl.eduBackground: Advanced hepatocellular carcinoma (HCC) generally has a dismal prognosis. Bone metastases from HCC are infrequent, with a poorer prognosis. However, the survival influencing factors are not yet well understood.Aim: The aim of the present study was to assess the clinical features and tumor characteristics of HCC patients with bone metastasis.Methods: A cohort of 170,576 adult patients with HCC was studied using the National Cancer Database (NCDB) spanning from 2010 to 2019, and within this group, 5285 patients (3.1%) were diagnosed with bone metastasis. We performed the Kaplan–Meier method to calculate the median overall survival (OS). We included demographics (age at diagnosis, gender, race, insurance status), comorbidity score, and treatment characteristics.Results: Of a total of 5285 HCC patients with bone metastasis, 86.2% were male and 61.2% were non-Hispanic white. Most patients (55.1%) were below 65, and 89% had a total Charlson-Deyo comorbidity score of under 3. Among patients with known tumor grade, 24.8% had well-differentiated tumors, and 36.1% had poorly differentiated tumors. Chemotherapy was administrated to 39.5% of patients. In univariate analysis, patients with well-differentiated tumors had better OS compared to poorly differentiated tumors (5.4 months vs 3.0 months, p = 0.001). Patients who received single or multiagent chemotherapy were significantly associated with improved OS compared to patients who did not receive chemotherapy (7.0 and 8.5 months vs 1.94 months, respectively). We also found mortality difference between age, comorbidity scores, facility types and race groups.Conclusion: In this cohort analysis of NCDB data, we found better OS in treatment receipt, lower tumor grade, younger age, non-Hispanic Black and Hispanic race, treatment at academic facility and lower comorbidity score in HCC patients with bone metastasis. The study results may have a consequential impact on the treatment decisions for HCC patients with bone metastasis.Keywords: hepatocellular carcinoma, HCC, bone metastasis

Published
2023

13. Contributors

Author

Akkari, Alessandra Cristina Santos, primary, Baranov, L.A., additional, Barbeito, Gonzalo, additional, Barros, Graiciany de Paula, additional, Bochkov, Alexander V., additional, Bolognani, Silverio, additional, Bolvashenkov, Igor, additional, Branković, Dejan Lj., additional, Chen, Liwei, additional, Chiñas-Sánchez, P., additional, Costa, Antônio Carlos Lopes da, additional, da Costa, Laís Santiago, additional, Diogo, Ricardo A., additional, Diván, Mario José, additional, Dohi, Tadashi, additional, dos Santos, Neri, additional, Dui, Hongyan, additional, Farsi, Mohammad Ali, additional, Frenkel, Ilia, additional, Hernández-López, A., additional, Herzog, Hans-Georg, additional, Janicˇić Milovanović, Valentina Z., additional, Kammermann, Jörg, additional, Knezevic, Jezdimir, additional, Kubota, Kento, additional, Liu, Zhao, additional, López-Juárez, I., additional, Loures, Eduardo F.R., additional, Ma, Jing, additional, Mazzucato, Stefania, additional, Mendez, G.M., additional, Milovanović, Zdravko N., additional, Munhoz, Igor Polezi, additional, Nadjafi, Mohammad, additional, Okamura, Hiroyuki, additional, Pereira, Luciana, additional, Pickl, Stefan Wolfgang, additional, Rios-Cabrera, R., additional, Rozenberg, E.N., additional, Ruiz-Tamayo, J., additional, Rutiaga-Quezada, M, additional, Sánchez Reynoso, María Laura, additional, Shubinsky, I.B., additional, Soares, Wellington Antonio, additional, Triantafyllou, Ioannis S., additional, Vasconcelos, Vanderley, additional, Vázquez-López, J.A., additional, Zaitseva, Elena, additional, Zharikova, Maryna, additional, and Zheng, Xiaoqian, additional

Published
2023
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15. Effectiveness of the Zero Surgical Infection Project (ZSIP) in Spanish hospitals 2017–2021: a prospective cohort study.

Author

Navarro-Gracia, J.F., Gómez-Romero, F.J., Lozano-García, F.J., Ortí-Lucas, R., Delgado-De los Reyes, J.A., Fernández-Prada, M., and Herruzo-Cabrera, R.

Abstract

The Zero Surgical Infection Project (ZSIP) in Spain is a nationwide programme to prevent surgical site infections (SSIs), sponsored by the Ministry of Health. The programme includes the application of a bundle of five key preventive measures (5PM): peri-operative antibiotic prophylaxis (PAP), skin antisepsis (SA), hair removal (HR), normothermia and normoglycaemia. To assess the effectiveness of the 5PM, applied in a set of Spanish public hospitals between 2017 and 2021, under standard conditions of surgical health care in Spain. This prospective cohort study of 33,240 patients from the ZSIP Registry (National Database Network) included surveillance of SSI data of selected surgical interventions, compliance data and other risk factors. Compliance with the 5PM bundle was verified through a specific checklist. The intervention and comparison groups were patients who were compliant with the 5PM bundle and patients who were not compliant with the 5PM bundle, respectively. Adjusted odds ratios (OR) and preventive fractions (PF) were calculated using logistic regression. The overall SSI rates for patients in the compliant group and non-compliant group were 4.77% and 6.90%, respectively. Overall compliance with the 5PM bundle was 35.9%, and the compliance rates were highest for PAP (87.2%), SA (82.2%) and HR (78.7%). Compliance with the 5PM bundle had a PF of 32% and adjusted OR of 0.68 (95% confidence interval 0.60–0.76). The ZSIP, implemented between 2017 and 2021 in Spain, had a significant level of effectiveness against SSIs. [ABSTRACT FROM AUTHOR]

Published
2025
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20. International Nosocomial Infection Control Consortium (INICC) report, data summary of 45 countries for 2012-2017: Device-associated module

Author

Riera, F.O., López, M., Maurizi, D.M., Desse, J.E., Pérez, I., Silva, G.C., Chaparro, G.J., Golschmid, D., Cabrera, R., Montanini, A.M., Bianchi, A.C., Vimercati, J., Rodríguez-del-Valle, M.C., Domínguez, C.V., Saul, P.A., Chediack, V., Piastrelini, M., Cardena, L.P., Ramasco, L., Olivieri, M.S., Gallardo, P.F., Juarez, P.D., Brito, M.P., Botta, P., Alvarez, G., Benchetrit, G., Caridi, M., Stagnaro, J.P., Bourlot, I., García, M., Arregui, N.V., Saeed, N.K., Abdul-Aziz, S., ALSayegh, S., Humood, M.Z., Mohamed-Ali, K., Swar, S., Magray, T.A.S., Aguiar-Portela, T.B., Sugette-de-Aguiar, T., Serpa-Maia, F.I., Fernandes-Alves-de-Lima, L., Teixeira-Josino, L.A., Sampaio-Bezerra, M., Furtado-Maia, R.C., Romário-Mendes, A., Alves-De-Oliveira, A., Vasconcelos-Carneiro, A.P., Anjos-Lima, J. Dos, Pinto-Coelho, K.H., Maciel-Canuto, M.L., Rocha-Batista, M.X., Moreira, T., Rodrigues-Amarilo, N., Lima-de-Barros, T.M., Guimarães, K. Arruda, Batista, C., Santos, C., de-Lima-Silva, F.J., Santos-Mota, E., Karla, L., Ferreira-de-Souza, M.C., Luzia, N., de-Oliveira, S.S, Takeda, C., Azevedo-Ferreira-Lima, D., Faheina, J., Coelho-Oliveira, L.M., do-Nascimento, S.C., Machado-Silva, V.L., Bento-Ferreira, Olszewski, J., Tenorio, M.T., Silva-Lemos, A.C., Ramos-Feijó, C.A., Cardoso, D.M., Correa-Barbosa, M.A., Assunção-Ponte, G., da-Silva-Escudero, D.V., Servolo-Medeiros, E.A., Andrade-Oliveira-Reis, M., Kostadinov, E.D., Dicheva, V.J., Petrov, M.M., Guo, C., Yu, H., Liu, T., Song, G., Wang, C., Cañas-Giraldo, L.M., Marin-Tobar, D.A., Trujillo-Ramirez, E.M., Andrea-Rios, P., Álvarez-Moreno, C., Linares, C., González-Rubio, P.A., Ariza-Ayala, B.E., Gamba-Moreno, L.J., Gualtero-Trujill, S.L., Segura-Sarmiento, S.J., Rodriguez-Pena, J., Ortega, R., Olarte, N., Pardo-Lopez, Y.A., Luis Marino Otela-Baicue, A., Vargas-Garcia, A.R., Roncancio, E.G., Gomez-Nieto, K., Espinosa-Valencia, M., Barahona-Guzman, N., Avila-Acosta, C., Raigoza-Martinez, W., Villamil-Gomez, W., Chapeta-Parada, E.G., Mindiola-Rochel, A.E., Corchuelo-Martinez, A.H., Martinez, A., Lagares-Guzman, A., Rodriguez-Ferrer, M., Yepes-Gomez, D., Muñoz-Gutierrez, G.A., Arguello-Ruiz, A., Zuniga-Chavarria, M.A., Maroto-Vargas, L., Valverde-Hernández, M., Solano-Chinchilla, A., Calvo-Hernandez, I., Chavarria-Ugalde, O., Tolari, G., Rojas-Fermin, R.A., Diaz-Rodriguez, C.V., Huascar, S., Ortiz, M., Bovera, M.M., Alquinga, N., Santacruz, G., Jara, E., Delgado, V., Salgado-Yepez, E., Valencia, F., Pelaez, C., Gonzalez-Flores, H.A., Coello-Gordon, E.E., Picoita, F., Arboleda, M., Garcia, M.F., Velez, J., Valle, M., Unigarro, L., Figueroa, V., Marin, K., Caballero-Narvaez, H., Bayani, V., Ahmed, S.A., Alansary, A.M., Hassan, A.R., Abdel-Halim, M.M., El-Fattah, M.A., Abdelaziz-Yousef, R.H., Hala, A., Abdelhady, K.M., Ahmed-Fouad, H., Mounir-Agha, H., Hamza, H.S., Salah, Z., Abdel-Aziz, D.M., Ibrahim, S.B., Helal, A.M., AbdelMassih, A.F., Mahmoud, A. Reham, Elawady, B., El-sherif, R.H., Fattah-Radwan, Y.A., Abdel-Mawla, T.S., Kamal-Elden, N.M., Kartsonaki, M., Rivera, D.M., Mandal, S., Mukherjee, S., Navaneet, P., Padmini, B., Sorabjee, J.S., Sakle, A.S., Potdar, M.S., Mane, D., Sale, H.K., Abdul-Gaffar, M.M., Kazi, M., Chabukswar, S., Anju, M., Gaikwad, D., Harshe, A., Blessymole, S., Nair, P.K., Khanna, D.K., Chacko, F., Rajalakshmi, A., Mubarak, A., Kharbanda, M., Kumar, S., Mathur, P., Saranya, S., Abubakar, F., Sampat, S., Raut, V., Biswas, S.K., Kelkar, R., Divatia, J.V., Chakravarthy, M., Gokul, B.N., Sukanya, R., Pushparaj, L., Thejasvini, A., Rangaswamy, S., Saini, N., Bhattacharya, C., Das, S., Sanyal, S., Chaudhury, B.N., Rodrigues, C., Khanna, G., Dwivedy, A., Binu, S., Shetty, S., Eappen, J., Valsa, T., Sriram, A., Todi, S.K., Bhattacharyya, M., Bhakta, A., Ramachandran, B., Krupanandan, R., Sahoo, P., Mohanty, N., Sahu, S., Misra, S., Ray, B., Pattnaik, S., Pillai, H., Warrier, A.R., Ranganathan, L., Mani, A.K., Rajagopal, S.K., Abraham, B.K., Venkatraman, R., Ramakrishnan, N., Devaprasad, D., Siva, K., Divekar, D.G., Satish Kavathekar, M.S., Suryawanshi, M.V., Poojary, A., Sheeba, J., Patil, P., Kukreja, S., Varma, K., Narayanan, S., Sohanlal, T., Agarwal, A., Agarwal, M., Nadimpalli, G., Bhamare, S., Thorat, S., Sarda, O., Nadimpalli, P., Nirkhiwale, S., Gehlot, G.S., Bhattacharya, S., Pandya, N., Raphel, A.K.O., Zala, D., Mishra, S.B., Patel, M.H., Aggarwal, D.G.C., Jawadwal, B.Q., Pawar, N.K., Kardekar, S.N., Manked, A.N., Tamboli, A.S., Manked, A., Khety, Z., Singhal, T., Shah, S., Kothari, V., Naik, R., Narain, R., Sengupta, S., Karmakar, A., Mishra, S., Pati, B.K., Kantroo, V., Kansal, S., Modi, N., Chawla, R., Chawla, A., Roy, I., Bej, M., Mukherjee, P., Baidya, S., Durell, A., Vadi, S., Saseedharan, S., Anant, P., Edwin, J.P., Sen, N., Sandhu, K., Sharma, S., Palaniswamy, V., Sharma, P., Selvaraj, M., Saurabh, L., Punia, D.P., Soni, D.K., Misra, R., Harsvardhan, R., Azim, A., Kambam, C., Garg, A., Ekta, S., Lakhe, M., Sharma, C.B., Singh, G., Kaur, A., Singhal, S., Chhabra, K.D., Ramakrishnan, G., Kamboj, H., Pillai, S., Rani, P., Singla, D., Sanaei, A., Maghsudi, B., Sabetian, G., Masjedi, M., Shafiee, E., Nikandish, R., Paydar, S., Khalili, H.A., Moradi, A., Sadeghi, P., Bolandparvaz, S., Mubarak, S., Makhlouf, M., Awwad, M., Ayyad, O., Shaweesh, A.A., Khader, M.M., Alghazawi, A., Hussien, N., Alruzzieh, M., Mohamed, Y.K., ALazhary, M., Abdul Aziz, O.A., Alazmi, M., Mendoza, J., De Vera, P.A., Rillorta, A.S., de Guzman, M., Girvan, M., Torres, M., Alzahrani, N., Alfaraj, S., Gopal, U., Manuel, M.G., Alshehri, R., Lessing, L., Alzoman, H., Abdrahiem, J., Adballah, H., Thankachan, J., Gomaa, H., Asad, T., AL-Alawi, M., Al-Abdullah, N.A., Demaisip, N.L., Laungayan-Cortez, E., Cabato, A.F., Gonzales, J.M., Al Raey, M.A., Al-Darani, S.A., Aziz, M.R., Al-Manea, B., Samy, E., AlDalaton, M., Alaliany, M.J., Alabdely, H.M., Helali, N.J., Sindayen, G., Malificio, A.A., Al-Dossari, H.B., Kelany, A., Algethami, A.G., Mohamed, D., Yanne, L., Tan, A., Babu, S., Abduljabbar, S.M., Al-Zaydani, M.A., Ahmed, H., Al Jarie, A., Al-Qathani, A.S.M., Al-Alkami, H.Y., Alih, S.J.B., Gasmin-Aromin, R., Balon-Ubalde, E., Diab, H.H., Kader, N.A., Hassan-Assiry, I.Y., Albeladi, E., Aboushoushah, S., Qushmaq, N., Fernandez, J., Hussain, W.M., Rajavel, R.D., Bukhari, S.Z., Rushdi, H., Turkistani, A.A., Mushtaq, J.J., Bohlega, E., Simon, S., Damlig, E., Elsherbini, S.G., Abraham, S., Kaid, E., Al-Attas, A., Hawsawi, G., Hussein, B., Esam, B., Caminade, Y., Santos, A.J., Abdulwahab, M.H., Aldossary, A.H., Al-Suliman, S., AlTalib, A.A., Albaghly, N., HaqlreMia, M.E., Altowerqi, R., Ghalilah, K.M., Alradady, M., Al-Qatri, A., Chaouali, M., Shyrine, E.L., Philipose, J., Raees, M., AbdulKhalik, N.S., Madco, M., Acostan, C., Safwat, R., Halwani, M., Abdul-Aal, N.A.H., Thomas, A., Abdulatif, S.M., Ali-Karrar, M.A., Al-Gosn, N., Al-Hindi, A.A., Jaha, R.N., AlQahtani, S.N., Ayugat, E.P., Al-Hussain, M.I., Aldossary, A., Al-Talib, A.A., Haqlre-Mia, M.E., Briones, S., Krishnan, R., Tabassum, K., Alharbi, L., Madani, A., Al-Gethamy, M.A., Alamri, D.M., Spahija, G., Gashi, A., Kurian, A., George, S.M., Mohamed, A.M., Ramapurath, R.J., Varghese, S.T., Abdo, N.M., Foda-Salama, M., Al-Mousa, H.H., Omar, A.A., Salama, M.F., Toleb, M., Khamis, S., Kanj, S.S., Zahreddine, N.K., Kanafani, Z., Kardas, T., Ahmadieh, R., Hammoud, Z., Zeid, I., Al-Souheil, A., Ayash, H., Mahfouz, T., Kondratas, T., Grinkeviciute, D., Kevalas, R., Dagys, A., Mitrev, Z., Bogoevska-Miteva, Z., Jankovska, K., Guroska, S.T., Petrovska, M., Popovska, K., Ng, C., Hoon, Y.M., Hasan, YM.S., Othman-Jailani, M.I., Hadi-Jamaluddin, M.F., Othman, A.A., Zainol, H., Wan-Yusoff, W.N., Gan, C.S., Lum, L.C.S., Ling, C.S., Aziz, F.A., Zhazali, R., Abud-Wahab, M.R., Cheng, T.S., Elghuwael, I.M., Wan-Mat, W.R., Abd-Rahman, R., Perez-Gomez, H.R., Kasten-Monges, M., Esparza-Ahumada, S., Rodriguez-Noriega, E., Gonzalez-Diaz, E., Mayoral-Pardo, D., Cerero-Gudino, A., Altuzar-Figueroa, M.A., Perez-Cruz, J., Escobar-Vazquez, M., Aragon, D.M.L., Coronado-Magana, H., Mijangos-Mendez, J.C., Corona-Jimenez, F., Aguirre-Avalos, G., Lopez-Mateos, A., Martinez-Marroquin, M.Y., Montell-Garcia, M., Martinez-Martinez, A., Leon-Sanchez, E., Gomez-Flores, G., Ramirez, M., Gomez, M.E., Lozano, M., Mercado, V.N., Zamudio-Lugo, I., Gomez-Gonzalez, C.J., Miranda-Novales, M.G., Villegas-Mota, I., Reyes-Garcia, C., Ramirez-Morales, M.K., Sanchez-Rivas, M., Cureno-Diaz, M.A., Matias-Tellez, B., Gonzalez-Martinez, J., Juarez-Vargas, R., Pastor-Salinas, O., Gutierrez-Munoz, V.H., Conde-Mercado, J.M., Bruno-Carrasco, G., Manrique, M.A., Monroy-Colin, V.A., Cruz-Rivera, Z., Rodriguez-Pacheco, J., Cruz, N.L., Hernandez-Chena, B.E., Guido-Ramirez, O., Arteaga-Troncoso, G., Guerra-Infante, F.M., Lopez-Hurtado, M., Caleco, J.A. Denicia, Leyva-Medellin, E.E., Salamanca-Meneses, A., Cosio-Moran, C., Ruiz-Rendon, R., Aguilar-Angel, L.A., Sanchez-Vargas, M., Mares-Morales, R.C., Fernandez-Alvarez, L.C., Castillo-Cruz, B.V., Gonzalez-Ma, M.R., Zavala-Ramír, M.C., Rivera-Reyna, L., del-Moral-Rossete, L.G., Lopez-Rubio, C., Valadez-de-Alba, M., Bat-Erdene, A., Chuluunchimeg, K.H., Baatar, O., Batkhuu, B., Ariyasuren, Z., Bayasgalan, G., Baigalmaa, S., Uyanga, T.S., Suvderdene, P., Enkhtsetseg, D., Suvd-Erdene, D., Chimedtseye, E., Bilguun, G., Tuvshinbayar, M., Dorj, M., Khajidmaa, T., Batjargal, G., Naranpurev, M., Bolormaa, T., Battsetseg, T., Batsuren, Ch, Batsaikhan, N., Tsolmon, B., Saranbaatar, A., Natsagnyam, P., Nyamdawa, O., Madani, N., Abouqal, R., Zeggwagh, A.A., Berechid, K., Dendane, T.P., Koirala, A., Giri, R., Sainju, S., Acharya, S.P., Paul, N., Parveen, A., Raza, A., Nizamuddin, S., Sultan, F., Imran, X., Sajjad, R., Khan, M., Sana, F., Tayyab, N., Ahmed, A., Zaman, G., Khan, I., Khurram, F., Hussain, A., Zahra, F.T., Imtiaz, A., Daud, N., Sarwar, M., Roop, Z., Yusuf, S., Hanif, F., Shumaila, X., Zeb, J., Ali, S.R., Demas, S., Ariff, S., Riaz, A., Hussain, A.S., Kanaan, A., Jeetawi, R., Castaño, E.G., Moreno-Castillo, L.L., García-Mayorca, E., Prudencio-Leon, W.E., Vivas-Pardo, A., Changano-Rodriguez, M.V., Castillo-Bravo, L.I., Aibar-Yaranga, K.F., Marquez-Mondalgo, V.A., Mueras-Quevedo, J., Meza-Borja, C., Flor, J.L., Fernandez-Camacho, Y.M., Banda-Flores, C., Pichilingue-Chagray, J., Castaneda-Sabogal, A., Caoili, J.C., Mariano, M.C., Maglente, R.R., Santos, S., de-Guzman, G., Mendoza, M.T., Javellana, O.P., Tajanlangit, A.N.L., Tapang, A.R.D., Sg-Buenaflor, M.C., Labro, E., Carma, R., Dy, A.M.P., Fortin, J.D., Navoa-Ng, J.A., Cesar, J.L., Bonifacio, B.S., Llames, M.J.P., Gata, H.L.B., Tamayo, A.S., Calupit, H.K.E., Catcho, V.V., Bergosa, L.D., Abuy, M.T.B., Barteczko-Grajek, B., Rojek, S., Szczesny, A., Domanska, M., Lipinska, G., Jaroslaw, J., Wieczoreka, A., Szczykutowicza, A., Gawor, M., Piwoda, M., Rydz-Lutrzykowska, J., Grudzinska, M., Kolat-Brodecka, P., Smiechowicz, K., Tamowicz, B., Mikstacki, A., Grams, A., Sobczynski, P., Nowicka, M., Kretov, V., Shalapuda, V., Molkov, A., Puzanov, S., Utkin, I., Tchekulaev, A., Tulupova, V., Vasiljevic, S., Nikolic, L., Ristic, G., Eremija, J., Kojovic, J., Lekic, D., Simic, A., Hlinkova, S., Lesnakova, A., Kadankunnel, S.K., Abdo-Ali, M.M., Pimathai, R., Wanitanukool, S., Supa, N., Prasan, P., Luxsuwong, M., Khuenkaew, Y., Lamngamsupha, J., Siriyakorn, N., Prasanthai, V., Apisarnthanarak, A., Borgi, A., Bouziri, A., Cabadak, H., Tuncer, G.E., Bulut, C., Hatipoglu, C.A., Sebnem, F.E., Demiroz, A.P., Kaya, A., Ersoz, G., Kuyucu, N., Karacorlu, S., Oncul, O., Gorenek, L., Erdem, H., Yildizdas, D., Horoz, O.O., Guclu, E., Kaya, G., Karabay, O., Altindis, M., Oztoprak, N., Sahip, Y., Uzun, C., Erben, N., Usluer, G., Ozgunes, I., Ozcelik, M., Ceyda, B.M., Oral, M., Unal, N., Cigdem, Y.G., Bayar, M.K., Bermede, O., Saygili, S., Yesiler, I., Memikoglu, O., Tekin, R., Oncul, A., Gunduz, A., Ozdemir, D., Geyik, M.F., Erdogan, S.Y., Aygun, C., Dilek, A., Esen, S., Turgut, H., Sungurtekin, H., Ugurcan, D., Yarar, V., Bilir, Y., Bayram, N., Devrim, I., Agin, H., Ceylan, G., Yasar, N., Oruc, Y., Ramazanoglu, A., Turhan, O., Cengiz, M., Yalcin, A.N., Dursun, O., Gunasan, P., Kaya, S., Senol, G., Kocagoz, A.S., Al-Rahma, H., Annamma, P., El-Houfi, A., Vidal, H., Perez, F., D-Empaire, G., Ruiz, Y., Hernandez, D., Aponte, D., Salinas, E., Vidal, H.R., Navarrete, N., Vargas, R., Sanchez, E., Ngo Quy, C., Thu, T.A., Nguyet, L.T.T., Hang, P.T., Hang, T.T.T., Hanh, T.T.M., Anh, D.P.P., Rosenthal, Víctor Daniel, Bat-Erdene, Ider, Gupta, Debkishore, Belkebir, Souad, Rajhans, Prasad, Zand, Farid, Myatra, Sheila Nainan, Afeef, Majeda, Tanzi, Vito L, Muralidharan, S., Gurskis, Vaidotas, Al-Abdely, Hail M., El-Kholy, Amani, AlKhawaja, Safa A. Aziz, Sen, Suha, Mehta, Yatin, Rai, Vineya, Hung, Nguyen Viet, Sayed, Amani F., Guerrero-Toapanta, Fausto Marcos, Elahi, Naheed, Morfin-Otero, María del Rayo, Somabutr, Suwara, De-Carvalho, Braulio Matias, Magdarao, Mary Shine, Velinova, Velmira Angelova, Quesada-Mora, Ana Marcela, Anguseva, Tanja, Ikram, Aamer, Aguilar-de-Moros, Daisy, Duszynska, Wieslawa, Mejia, Nepomuceno, Horhat, Florin George, Belskiy, Vladislav, Mioljevic, Vesna, Di-Silvestre, Gabriela, Furova, Katarina, Gamar-Elanbya, May Osman, Gupta, Umesh, Abidi, Khalid, Raka, Lul, Guo, Xiuqin, Luque-Torres, Marco Tulio, Jayatilleke, Kushlani, Ben-Jaballah, Najla, Gikas, Achilleas, Sandoval-Castillo, Harrison Ronald, Trotter, Andrew, Valderrama-Beltrán, Sandra L., and Leblebicioglu, Hakan

Published
2020
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22. A Novel Splice-Site Mutation in the ELN Gene Suggests an Alternative Mechanism for Vascular Elastinopathies

Author

Velandia-Piedrahita CA, Morel A, Fonseca-Mendoza DJ, Huertas-Quiñones VM, Castillo D, Bonilla JD, Hernandez-Toro CJ, Miranda-Fernández MC, Restrepo CM, and Cabrera R

Subjects
svas, eln, adcl, coacervation, splicing, Medicine (General), R5-920, Genetics, QH426-470
Abstract

Camilo Andres Velandia-Piedrahita,1 Adrien Morel,2,* Dora Janeth Fonseca-Mendoza,2,* Victor Manuel Huertas-Quiñones,3– 5 David Castillo,6 Juan Diego Bonilla,7 Camilo José Hernandez-Toro,1 Marta Catalina Miranda-Fernández,1 Carlos Martin Restrepo,2 Rodrigo Cabrera1,2 1Laboratorio de Biología Molecular y Pruebas Diagnósticas de Alta Complejidad, Fundación Cardioinfantil‐Instituto de Cardiología, Bogotá, Colombia; 2Center for Research in Genetics and Genomics-CIGGUR, GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia; 3Instituto de Cardiopatías Congénitas, Fundación Cardioinfantil‐Instituto de Cardiología, Bogotá, Colombia; 4Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia; 5Facultad de Medicina, Universidad del Rosario, Bogotá, Colombia; 6Servicio de Dermatología, Fundación Para la Investigación en Dermatología FUNINDERMA, Bogotá, Colombia; 7Servicio de Dermatología, Universidad El Bosque, Bogotá, Colombia*These authors contributed equally to this workCorrespondence: Rodrigo CabreraLaboratorio de Biología Molecular y Pruebas Diagnósticas de Alta Complejidad, Fundación Cardioinfantil‐Instituto de Cardiología, Calle 163A # 13B-60, Bogotá CP 110131, ColombiaTel +57 1 6672727 ext 11611Fax +57 1 6672727 Ext 73206Email rcabrerap@cardioinfantil.orgAbstract: The ELN gene encodes elastin, a fundamental protein of the extracellular matrix that confers elasticity to different tissues including blood vessels. The formation of elastin fibers is a complex process involving monomer coacervation and subsequent crosslinking. Mutations in exons 1– 29 of the ELN gene have been linked to supravalvular aortic stenosis (SVAS) whereas mutations in exons 30– 33 are associated with autosomal dominant cutis laxa (ADCL). This striking segregation has led to the hypothesis that distinct molecular mechanisms underlie both diseases. SVAS is believed to arise through haploinsufficiency while ADCL is hypothesized to be caused by a dominant negative effect. Here, we describe a patient with SVAS harboring a novel splice-site mutation in the last exon of ELN. The location of this mutation is not consistent with current knowledge of SVAS, since all mutations reported in the C-terminus have been found in ADCL patients, and a thorough evaluation did not reveal significant skin involvement in this case. RT-PCR analysis of skin tissue showed that C-terminal mutations in the region can lead to the production of aberrant transcripts through intron retention and activation of cryptic splice sites and suggest that disruption of the very last exon can lead to functional haploinsufficiency potentially related to SVAS.Keywords: SVAS, ELN, ADCL, coacervation, splicing

Published
2020

23. Intelligent Telehealth System To Support Epilepsy Diagnosis

Author

Molina E, Sarmiento Torres CE, Salazar-Cabrera R, López DM, and Vargas-Cañas R

Subjects
electroencephalogram (eeg), electronic health record (ehr), machine learning, diagnostic support system., Medicine (General), R5-920
Abstract

Edward Molina,1 Camilo Ernesto Sarmiento Torres,2 Ricardo Salazar-Cabrera,1 Diego M López,1 Rubiel Vargas-Cañas2 1Telematics Department, Universidad del Cauca, Popayán, Cauca, Colombia; 2Department of Physics, Universidad del Cauca, Popayán, Cauca, ColombiaCorrespondence: Diego M López Tel +57 3015819362 Email dmlopez@unicauca.edu.coBackground: Availability and opportunity of epilepsy diagnostic services is a significant challenge, especially in developing countries with a low number of neurologists. The most commonly used test to diagnose epilepsy is electroencephalogram (EEG). A typical EEG recording lasts for 20 to 30 minutes; however, a specialist requires much more time to read it. Furthermore, no evidence was found in the literature on open-source systems for the cost-effective management of patient information using electronic health records (EHR) that adequately integrate EEG analysis for automatic identification of abnormal signals.Objective: To develop an integrated open-source EHR system for the management of the patients’ personal, clinical, and EEG data, and for automatic identification of abnormal EEG signals.Methods: The core of the system is an EHR and telehealth service based on the OpenMRS platform. On top of that, we developed an intelligent component to automatically detect abnormal segments of EEG tests using machine learning algorithms, as well as a service to annotate and visualize abnormal segments in EEG signals. Finally, we evaluated the intelligent component and the integrated system using precision, recall, and accuracy metrics.Results: The system allowed to manage patients’ information properly, store and manage the EEG tests recorded with a medical EEG device, and to detect abnormal segments of signals with a precision of 85.10%, a recall of 97.16%, and an accuracy of 99.92%.Conclusion: Digital health is a multidisciplinary field of research in which artificial intelligence is playing a significant role in boosting traditional health services. Notably, the developed system could significantly reduce the time a neurologist spends in the reading of an EEG for the diagnosis of epilepsy, saving approximately 65– 75% of the time consumed. It can be used in a telehealth environment. In this way, the availability and provision of diagnostic services for epilepsy management could be improved, especially in developing countries where the number of neurologists is low.Keywords: electroencephalogram, electronic health record, machine learning, diagnostic support system, EEG, EHR

Published
2020

24. Usos y aplicaciones de bases de datos hidrometeorológicos globales en la gestión del agua en zonas con escasez de datos

Author

Araneda-Cabrera, R., Álvarez, M., Puertas, J., Araneda-Cabrera, R., Álvarez, M., and Puertas, J.

Abstract

La gestión adecuada de los recursos hídricos es esencial para garantizar el acceso sostenible al agua dulce. Este estudio se centra en informar sobre la situación actual y posibles situaciones futuras de la disponibilidad de agua mediante análisis de balances hídricos y análisis de sequías en Angola y en la cuenca del río Cuvelai. La escasez de estaciones de medición hidrológicas y meteorológicas dificulta la recopilación de datos precisos por lo que se utilizan bases de datos globales como TerraClimate y CHIRPS para obtener estimaciones y calcular índices de sequía. Se identificaron que las zonas con altas temperaturas y escasa precipitación enfrentan mayor déficit hídrico y riesgos de sequía. Además, se proyecta un crecimiento significativo de la población, lo que aumentará la presión sobre los recursos hídricos. El estudio sugiere estrategias de mitigación y planificación para enfrentar los desafíos futuros debido al cambio climático y el aumento poblacional.

Published
2024

25. Controlling magnetic order and quantum disorder in one- and zero-dimensional molecule-based magnets

Author

Lancaster, T., Goddard, P. A., Blundell, S. J., Foronda, F. R., Ghannadzadeh, S., Möller, J. S., Baker, P. J., Pratt, F. L., Baines, C., Huang, L., Wosnitza, J., McDonald, R. D., Modic, K. A., Singleton, J., Topping, C. V., Beale, T. A. W., Xiao, F., Schlueter, J. A., Cabrera, R. D., Carreiro, K. E., Tran, H. E., and Manson, J. L.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We investigate the structural and magnetic properties of two molecule-based magnets synthesized from the same starting components. Their different structural motifs promote contrasting exchange pathways and consequently lead to markedly different magnetic ground states. Through examination of their structural and magnetic properties we show that [Cu(pyz)(H$_{2}$O)(gly)$_{2}$](ClO$_{4}$)$_{2}$ may be considered a quasi-one-dimensional quantum Heisenberg antiferromagnet while the related compound [Cu(pyz)(gly)](ClO$_{4}$), which is formed from dimers of antiferromagnetically interacting Cu$^{2+}$ spins, remains disordered down to at least 0.03 K in zero field, but shows a field-temperature phase diagram reminiscent of that seen in materials showing a Bose-Einstein condensation of magnons., Comment: 5 pages, 4 figures, supplemental information (6 pages, 2 figures) also included

Published
2013
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27. Adverse Effects in Elderly Patients (≥ 85 years old) with Advanced Basal Cell Carcinoma Treated with Sonidegib: A multicenter retrospective study

Author

Martos-Cabrera, L., primary, Bonfill Ortí, M., additional, Deza, G., additional, Fernandez-de-Misa Cabrera, R., additional, Hernandez-Hernandez, M.N., additional, Abril Pérez, C., additional, Botella-Estrada, R., additional, Ciudad Blanco, C., additional, Jaka, A., additional, Just-Sarobé, M., additional, Conde-Taboada, A., additional, Mayor Arenal, M., additional, Vargas-Laguna, E., additional, Masferrer, E., additional, Alcaraz León, I., additional, Leal, L., additional, Medina Montalvo, S., additional, Polo, I., additional, Turrión, L., additional, Hernández, B., additional, Soria, A., additional, Delgado, Y., additional, Beá-Ardebol, S., additional, and Rodríguez-Jiménez, P., additional

Published
2024
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29. AN INTEGRATING SPHERE SPECTROPHOTOMETER PROTOTYPE PROTOTIPO DE ESPECTROFOTÓMETRO DE ESFERA INTEGRADORA.

Author

Hernandez-Rayas, A., Montes-Ramirez, E., Gomez, E. Sarmiento, Cordova-Fraga, T., and Cabrera, R. Guzmán

Subjects
QUANTITATIVE research, QUALITATIVE research, SIGNAL processing, SPHERES, RHINOCEROSES, SPECTROPHOTOMETERS
Abstract

Spectroscopy is essential for research in the qualitative and quantitative analysis of samples. In recent years, the need to develop portable and accessible equipment for sample characterization has reduced real-time analysis. The objective is to design and build a prototype of a portable spectrophotometer with an integrating sphere using tools such as Rhinoceros and Trace-Pro for its theoretical design and radiation simulation. The result is an integrating sphere 3D printed with PLA material and an internal coating with a 95% high reflectance paint. The AS7265 Triad module is the detector, along with signal processing to obtain spectra from control samples. The spectral profiles obtained were comparable with commercial equipment, validating the viability of the measurement system as the first spectroscopic instrument in the field, in complement to other spectroscopic techniques. This breakthrough promises to facilitate research in the field and in environments where mobility and accessibility are priorities. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Fluorescence enzymatic assay for bacterial polyphosphate kinase 1 (PPK1) as a platform for screening antivirulence molecules

Author

Campos F, Álvarez JA, Ortiz-Severín J, Varas MA, Lagos CF, Cabrera R, Álvarez SA, and Chávez FP

Subjects
Antivirulence, Antimicrobial, Affinity purification, Polyphosphate kinase, DAPI, Fluorescence enzymatic activity, Infectious and parasitic diseases, RC109-216
Abstract

Francisca Campos,1 Javiera A Álvarez,1 Javiera Ortiz-Severín,1 Macarena A Varas,1 Carlos F Lagos,2 Ricardo Cabrera,3 Sergio A Álvarez,4 Francisco P Chávez11Laboratorio de Microbiología de Sistemas, Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago de Chile, Chile; 2Chemical Biology & Drug Discovery Laboratory, Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago de Chile, Chile; 3Laboratorio de Bioquímica y Biología Molecular, Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago de Chile, Chile; 4Laboratorio de Microbiología, Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas Y Farmacéuticas, Universidad de Chile, Santiago de Chile, ChileAbstract: Inorganic polyphosphate (polyP) and its metabolic enzymes are important in several cellular processes related with virulence and antibiotic susceptibility. Accordingly, bacterial polyP synthesis has been proposed as a good target for designing novel antivirulence molecules as alternative to conventional antibiotics. In most pathogenic bacteria, polyphosphate kinase 1 (PPK1), in charge of polyP synthesis from ATP, is widely conserved. Current colorimetric and radioactive polyP synthesis enzymatic assays are not suitable for high-throughput screening of PPK1 inhibitors. Given the ability of polyP to modify the excitation-emission spectra of DAPI (4ʹ-6-diamidino-2-phenylindole), a fluorescence assay was previously developed by using a purified recombinant PPK1 enzyme from Escherichia coli. In this work we have developed a suitable methodology for high-throughput measurement of E. coli PPK1 activity. This platform can be used for the screening putative antimicrobial molecules for related enteropathogenic bacteria.Keywords: antivirulence, antimicrobial, affinity purification, polyphosphate kinase, DAPI, fluorescence enzymatic activity

Published
2019

32. Quantum/Classical Interface: Fermion Spin

Author

Baylis, W. E., Cabrera, R., and Keselica, D.

Subjects
Quantum Physics
Abstract

Although intrinsic spin is usually viewed as a purely quantum property with no classical analog, we present evidence here that fermion spin has a classical origin rooted in the geometry of three-dimensional physical space. Our approach to the quantum/classical interface is based on a formulation of relativistic classical mechanics that uses spinors. Spinors and projectors arise naturally in the Clifford's geometric algebra of physical space and not only provide powerful tools for solving problems in classical electrodynamics, but also reproduce a number of quantum results. In particular, many properites of elementary fermions, as spin-1/2 particles, are obtained classically and relate spin, the associated g-factor, its coupling to an external magnetic field, and its magnetic moment to Zitterbewegung and de Broglie waves. The relationship is further strengthened by the fact that physical space and its geometric algebra can be derived from fermion annihilation and creation operators. The approach resolves Pauli's argument against treating time as an operator by recognizing phase factors as projected rotation operators., Comment: 18 pp., no figures

Published
2007

33. Overcoming the su(2^n) sufficient condition for the coherent control of n-qubit systems

Author

Cabrera, R., Rangan, C., and Baylis, W. E.

Subjects
Quantum Physics
Abstract

We study quantum systems with even numbers N of levels that are completely state-controlled by unitary transformations generated by Lie algebras isomorphic to sp(N) of dimension N(N+1)/2. These Lie algebras are smaller than the respective su(N) with dimension N^2-1. We show that this reduction constrains the Hamiltonian to have symmetric energy levels. An example of such a system is an n-qubit system. Using a geometric representation for the quantum wave function of a finite system, we present an explicit example that shows a two-qubit system can be controlled by the elements of the Lie algebra sp(4) (isomorphic to spin(5) and so(5)) with dimension ten rather than su(4) with dimension fifteen. These results enable one to envision more efficient algorithms for the design of fields for quantum-state engineering, and they provide more insight into the fundamental structure of quantum control., Comment: 13 pp., 2 figures

Published
2007
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34. Average Fidelity in n-Qubit systems

Author

Cabrera, R. and Baylis, W. E.

Subjects
Quantum Physics
Abstract

This letter generalizes the expression for the average fidelity of single qubits, as found by Bowdrey et al., to the case of n qubits. We use a simple algebraic approach with basis elements for the density-matrix expansion expressed as Kronecker products of n Pauli spin matrices. An explicit integration over initial states is avoided by invoking the invariance of the state average under unitary transformations of the initial density matrix. The results have applications to measurements of quantum information, for example in ion-trap and NMR experiments., Comment: 4 pages, no figures. Revision includes additional references and a more detailed symmetry argument

Published
2007
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35. Control and Representation of n-qubit Quantum Systems

Author

Baylis, W. E., Cabrera, R., and Rangan, C.

Subjects
Quantum Physics
Abstract

Just as any state of a single qubit or 2-level system can be obtained from any other state by a rotation operator parametrized by three real Euler angles, we show how any state of an n-qubit or 2^n-level system can be obtained from any other by a compact unitary transformation with 2^(n+1)-1 real angles, 2^n of which are azimuthal-like and the rest polar-like. The results follow from a modeling of the Hilbert space of n-qubits by a minimal left ideal of an associative algebra. This representation is expected to be useful in the design of new compact control techniques or more efficient algorithms in quantum computing., Comment: 4 pages, no figures, revision corrects a couple of minor errors

Published
2006

39. Molecular solids at high pressure

Author

Quesada Cabrera, R.

Subjects
540
Abstract

High pressure science has extended its applications beyond its classic domain of physics and geophysics. Diamond anvil cell techniques have been adapted to the study on chemical transformations at high pressure and pressure-modified reaction kinetics, contributing to a better understanding of reaction processes and new preparative strategies and opening unexplored chemical pathways for new materials. In this thesis, we aim to present examples of the contribution of the diamond anvil cell to high pressure science, as well as to explore potential applications for this revolutionary perturbation tool. We first introduce a study on sodium silicide (NaSi), a Zintl phase, a potential compound for polymerization at high pressure. This system is an interesting model that illustrates some of the common processes observed in high pressure research. The investigation on the behaviour of sodium orthonitrate (Na3NO4) at high pressure aimed to analyse possible routes towards the synthesis of as yet unknown orthocarbonates and maybe discover compounds with an ever higher coordination for nitrogen or a NO4-containing three-dimensional network. Recently synthesised polyoxometalate (POM) clusters have shown interesting thermochromic properties, which has been related to a redox reaction occurring within the metal-oxygen cage. At high temperature, it has been proposed that the SO3 heteroanion groups contained in the cluster transform to SO4 by the introduction of bridging oxygen from the cage. An oxygen rearrangement would reduce up to four metal atoms, inducing the colour change. We aimed to investigate here whether a similar electron localization process is possible upon compression of these systems. Finally, we develop pioneering high-pressure DAC experiments on amyloid fibrils, using synchrotron X-ray diffraction. Our approach allows us to estimate the Young’s modulus of these biological macromolecular materials and discuss their low compressibility for applications in nanotechnology.

Published
2009

47. Survey of wound-induced ethylene production by excised root segments

Author

Cabrera, R M and Saltveit, Mikal E

Abstract

Ethylene production was measured from excised 10-mm apical and subapical root segments from 50 cultivars in 19 species of 7 families. Monocotyledonous species tended to have much lower rates of ethylene production than dicotyledonous species. Ethylene production was generally higher in apical root segments than in subapical segments within 1 h of wounding. However, cultivars of Cucumis melo, C. sativus, Helianthus annuus, Hibiscus esculentus, and Zea mays had higher rates of ethylene production from subapical segments. In apical root segments, Phaseolus aureus cv. Berken had the highest ethylene production rate (76.7 etal g(-1) h(-1)), while Zea mays cv. Silver Queen had the lowest rate (0.6 etal g(-1) h(-1)). In subapical root segments, Cucumis sativus cv. Armenian had the highest rate (55.7 etal g(-1) h(-1)), while Zea mays cv. Silver Queen again had the lowest rate (0.6 etal g(-1) h(-1)). The many different responses in magnitude and kinetics of wound-induced ethylene production among the species, cultivars and tissues should provide interesting and useful systems with which to study wound responses and induced ethylene production.

Published
2003

49. Evaluación de los costes asociados a la enfermedad de pacientes con linfoma cutáneo de células T en España: análisis en función del estadio clínico (estudio MICADOS)

Author

Navarro Matilla, B., primary, Ortiz Romero, P.L., additional, Pujol Vallverdú, R.M., additional, Combalia Escudero, A., additional, Zapata Paz, I., additional, González Barca, E., additional, Muniesa Montserrat, C., additional, Morillo Andújar, M., additional, Pérez Ferriols, A., additional, Román Curto, C., additional, Fernández de Misa Cabrera, R., additional, Hospital Gil, M., additional, Marín Niebla, A., additional, Rios Rull, P.J., additional, de la Cruz Vicente, F., additional, Izu Belloso, R.M., additional, Martín García-Sancho, A., additional, Parera Amer, M.E., additional, Córdoba Mascuñano, R., additional, Ramón Quiles, M.D., additional, Saus Carreres, A., additional, del Campo García, R., additional, Machan, S., additional, Viguera Ester, P., additional, and Blanco Garnelo, J., additional

Published
2023
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