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2. Basic concepts of mixture toxicity and relevance for risk evaluation and regulation

Author

Bloch, Denise, Diel, Patrick, Epe, Bernd, Hellwig, Michael, Lampen, Alfonso, Mally, Angela, Marko, Doris, Villar Fernández, María A., Guth, Sabine, Roth, Angelika, Marchan, Rosemarie, Ghallab, Ahmed, Cadenas, Cristina, Nell, Patrick, Vartak, Nachiket, van Thriel, Christoph, Luch, Andreas, Schmeisser, Sebastian, Herzler, Matthias, Landsiedel, Robert, Leist, Marcel, Marx-Stoelting, Philip, Tralau, Tewes, and Hengstler, Jan G.

Published
2023
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3. Alterations in the hepatocyte epigenetic landscape in steatosis

Author

Maji, Ranjan Kumar, Czepukojc, Beate, Scherer, Michael, Tierling, Sascha, Cadenas, Cristina, Gianmoena, Kathrin, Gasparoni, Nina, Nordström, Karl, Gasparoni, Gilles, Laggai, Stephan, Yang, Xinyi, Sinha, Anupam, Ebert, Peter, Falk-Paulsen, Maren, Kinkley, Sarah, Hoppstädter, Jessica, Chung, Ho-Ryun, Rosenstiel, Philip, Hengstler, Jan G., Walter, Jörn, Schulz, Marcel H., Kessler, Sonja M., and Kiemer, Alexandra K.

Published
2023
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5. Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth

Author

Keller, Magdalena, Rohlf, Katharina, Glotzbach, Annika, Leonhardt, Gregor, Lüke, Simon, Derksen, Katharina, Demirci, Özlem, Göçener, Defne, AlWahsh, Mohammad, Lambert, Jörg, Lindskog, Cecilia, Schmidt, Marcus, Brenner, Walburgis, Baumann, Matthias, Zent, Eldar, Zischinsky, Mia-Lisa, Hellwig, Birte, Madjar, Katrin, Rahnenführer, Jörg, Overbeck, Nina, Reinders, Jörg, Cadenas, Cristina, Hengstler, Jan G., Edlund, Karolina, and Marchan, Rosemarie

Published
2023
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6. Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis

Author

Ghallab, Ahmed, González, Daniela, Strängberg, Ellen, Hofmann, Ute, Myllys, Maiju, Hassan, Reham, Hobloss, Zaynab, Brackhagen, Lisa, Begher-Tibbe, Brigitte, Duda, Julia C., Drenda, Carolin, Kappenberg, Franziska, Reinders, Joerg, Friebel, Adrian, Vucur, Mihael, Turajski, Monika, Seddek, Abdel-latief, Abbas, Tahany, Abdelmageed, Noha, Morad, Samy A.F., Morad, Walaa, Hamdy, Amira, Albrecht, Wiebke, Kittana, Naim, Assali, Mohyeddin, Vartak, Nachiket, van Thriel, Christoph, Sous, Ansam, Nell, Patrick, Villar-Fernandez, Maria, Cadenas, Cristina, Genc, Erhan, Marchan, Rosemarie, Luedde, Tom, Åkerblad, Peter, Mattsson, Jan, Marschall, Hanns-Ulrich, Hoehme, Stefan, Stirnimann, Guido, Schwab, Matthias, Boor, Peter, Amann, Kerstin, Schmitz, Jessica, Bräsen, Jan H., Rahnenführer, Jörg, Edlund, Karolina, Karpen, Saul J., Simbrunner, Benedikt, Reiberger, Thomas, Mandorfer, Mattias, Trauner, Michael, Dawson, Paul A., Lindström, Erik, and Hengstler, Jan G.

Published
2024
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8. Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity

Author

Hassan, Reham, Friebel, Adrian, Brackhagen, Lisa, Hobloss, Zaynab, Myllys, Maiju, González, Daniela, Albrecht, Wiebke, Mohammed, Elsayed S. I., Seddek, Abdel-latif, Marchan, Rosemarie, Cadenas, Cristina, Cramer, Benedikt, Humpf, Hans-Ulrich, Hartl, Lukas, Simbrunner, Benedikt, Reiberger, Thomas, Trauner, Michael, Hoehme, Stefan, Degen, Gisela H., Hengstler, Jan G., and Ghallab, Ahmed

Published
2022
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10. Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells

Author

Nell, Patrick, Kattler, Kathrin, Feuerborn, David, Hellwig, Birte, Rieck, Adrian, Salhab, Abdulrahman, Lepikhov, Konstantin, Gasparoni, Gilles, Thomitzek, Antonia, Belgasmi, Katharina, Blüthgen, Nils, Morkel, Markus, Küppers-Munther, Barbara, Godoy, Patricio, Hay, David C., Cadenas, Cristina, Marchan, Rosemarie, Vartak, Nachiket, Edlund, Karolina, Rahnenführer, Jörg, Walter, Jörn, and Hengstler, Jan G.

Published
2022
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11. In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay

Author

Brecklinghaus, Tim, Albrecht, Wiebke, Duda, Julia, Kappenberg, Franziska, Gründler, Lisa, Edlund, Karolina, Marchan, Rosemarie, Ghallab, Ahmed, Cadenas, Cristina, Rieck, Adrian, Vartak, Nachiket, Tolosa, Laia, Castell, José V., Gardner, Iain, Halilbasic, Emina, Trauner, Michael, Ullrich, Anett, Zeigerer, Anja, Demirci Turgunbayer, Özlem, Damm, Georg, Seehofer, Daniel, Rahnenführer, Jörg, and Hengstler, Jan G.

Published
2022
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12. Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease

Author

Campos, Gisela, Schmidt-Heck, Wolfgang, De Smedt, Jonathan, Widera, Agata, Ghallab, Ahmed, Pütter, Larissa, González, Daniela, Edlund, Karolina, Cadenas, Cristina, Marchan, Rosemarie, Guthke, Reinhard, Verfaillie, Catherine, Hetz, Claudio, Sachinidis, Agapios, Braeuning, Albert, Schwarz, Michael, Weiß, Thomas S., Banhart, Benjamin K., Hoek, Jan, Vadigepalli, Rajanikanth, Willy, Jeffrey, Stevens, James L., Hay, David C., Hengstler, Jan G., and Godoy, Patricio

Published
2020
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13. Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis

Author

Ghallab, Ahmed, primary, González, Daniela, additional, Strängberg, Ellen, additional, Hofmann, Ute, additional, Myllys, Maiju, additional, Hassan, Reham, additional, Hobloss, Zaynab, additional, Brackhagen, Lisa, additional, Begher-Tibbe, Brigitte, additional, Duda, Julia C., additional, Drenda, Carolin, additional, Kappenberg, Franziska, additional, Reinders, Joerg, additional, Friebel, Adrian, additional, Vucur, Mihael, additional, Turajski, Monika, additional, Seddek, Abdel-latief, additional, Abbas, Tahany, additional, Abdelmageed, Noha, additional, Morad, Samy A.F., additional, Morad, Walaa, additional, Hamdy, Amira, additional, Albrecht, Wiebke, additional, Kittana, Naim, additional, Assali, Mohyeddin, additional, Vartak, Nachiket, additional, van Thriel, Christoph, additional, Sous, Ansam, additional, Nell, Patrick, additional, Villar-Fernandez, Maria, additional, Cadenas, Cristina, additional, Genc, Erhan, additional, Marchan, Rosemarie, additional, Luedde, Tom, additional, Åkerblad, Peter, additional, Mattsson, Jan, additional, Marschall, Hanns-Ulrich, additional, Hoehme, Stefan, additional, Stirnimann, Guido, additional, Schwab, Matthias, additional, Boor, Peter, additional, Amann, Kerstin, additional, Schmitz, Jessica, additional, Bräsen, Jan H., additional, Rahnenführer, Jörg, additional, Edlund, Karolina, additional, Karpen, Saul J., additional, Simbrunner, Benedikt, additional, Reiberger, Thomas, additional, Mandorfer, Mattias, additional, Trauner, Michael, additional, Dawson, Paul A., additional, Lindström, Erik, additional, and Hengstler, Jan G., additional

Published
2023
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15. Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Author

Albrecht, Wiebke, Kappenberg, Franziska, Brecklinghaus, Tim, Stoeber, Regina, Marchan, Rosemarie, Zhang, Mian, Ebbert, Kristina, Kirschner, Hendrik, Grinberg, Marianna, Leist, Marcel, Moritz, Wolfgang, Cadenas, Cristina, Ghallab, Ahmed, Reinders, Jörg, Vartak, Nachiket, van Thriel, Christoph, Golka, Klaus, Tolosa, Laia, Castell, José V., Damm, Georg, Seehofer, Daniel, Lampen, Alfonso, Braeuning, Albert, Buhrke, Thorsten, Behr, Anne-Cathrin, Oberemm, Axel, Gu, Xiaolong, Kittana, Naim, van de Water, Bob, Kreiling, Reinhard, Fayyaz, Susann, van Aerts, Leon, Smedsrød, Bård, Ellinger-Ziegelbauer, Heidrun, Steger-Hartmann, Thomas, Gundert-Remy, Ursula, Zeigerer, Anja, Ullrich, Anett, Runge, Dieter, Lee, Serene M. L., Schiergens, Tobias S., Kuepfer, Lars, Aguayo-Orozco, Alejandro, Sachinidis, Agapios, Edlund, Karolina, Gardner, Iain, Rahnenführer, Jörg, and Hengstler, Jan G.

Published
2019
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16. Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

Author

Grinberg, Marianna, Stöber, Regina M., Albrecht, Wiebke, Edlund, Karolina, Schug, Markus, Godoy, Patricio, Cadenas, Cristina, Marchan, Rosemarie, Lampen, Alfonso, Braeuning, Albert, Buhrke, Thorsten, Leist, Marcel, Oberemm, Axel, Hellwig, Birte, Kamp, Hennicke, Gardner, Iain, Escher, Sylvia, Taboureau, Olivier, Aguayo-Orozco, Alejandro, Sachinidis, Agapios, Ellinger-Ziegelbauer, Heidrun, Rahnenführer, Jörg, and Hengstler, Jan G.

Published
2018
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18. Supplementary tables S1-S5, S8 and S9 from Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma

Author

Marchan, Rosemarie, primary, Büttner, Bettina, primary, Lambert, Jörg, primary, Edlund, Karolina, primary, Glaeser, Iris, primary, Blaszkewicz, Meinolf, primary, Leonhardt, Gregor, primary, Marienhoff, Lisa, primary, Kaszta, Darius, primary, Anft, Moritz, primary, Watzl, Carsten, primary, Madjar, Katrin, primary, Grinberg, Marianna, primary, Rempel, Eugen, primary, Hergenröder, Roland, primary, Selinski, Silvia, primary, Rahnenführer, Jörg, primary, Lesjak, Michaela S., primary, Stewart, Joanna D., primary, Cadenas, Cristina, primary, and Hengstler, Jan G., primary

Published
2023
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19. Supplemental methods and figure legends from Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma

Author

Marchan, Rosemarie, primary, Büttner, Bettina, primary, Lambert, Jörg, primary, Edlund, Karolina, primary, Glaeser, Iris, primary, Blaszkewicz, Meinolf, primary, Leonhardt, Gregor, primary, Marienhoff, Lisa, primary, Kaszta, Darius, primary, Anft, Moritz, primary, Watzl, Carsten, primary, Madjar, Katrin, primary, Grinberg, Marianna, primary, Rempel, Eugen, primary, Hergenröder, Roland, primary, Selinski, Silvia, primary, Rahnenführer, Jörg, primary, Lesjak, Michaela S., primary, Stewart, Joanna D., primary, Cadenas, Cristina, primary, and Hengstler, Jan G., primary

Published
2023
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20. Marchan Supplementary Table 7 from Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma

Author

Marchan, Rosemarie, primary, Büttner, Bettina, primary, Lambert, Jörg, primary, Edlund, Karolina, primary, Glaeser, Iris, primary, Blaszkewicz, Meinolf, primary, Leonhardt, Gregor, primary, Marienhoff, Lisa, primary, Kaszta, Darius, primary, Anft, Moritz, primary, Watzl, Carsten, primary, Madjar, Katrin, primary, Grinberg, Marianna, primary, Rempel, Eugen, primary, Hergenröder, Roland, primary, Selinski, Silvia, primary, Rahnenführer, Jörg, primary, Lesjak, Michaela S., primary, Stewart, Joanna D., primary, Cadenas, Cristina, primary, and Hengstler, Jan G., primary

Published
2023
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21. CCR Translation for This Article from A Comprehensive Analysis of Human Gene Expression Profiles Identifies Stromal Immunoglobulin κ C as a Compatible Prognostic Marker in Human Solid Tumors

Author

Schmidt, Marcus, primary, Hellwig, Birte, primary, Hammad, Seddik, primary, Othman, Amnah, primary, Lohr, Miriam, primary, Chen, Zonglin, primary, Boehm, Daniel, primary, Gebhard, Susanne, primary, Petry, Ilka, primary, Lebrecht, Antje, primary, Cadenas, Cristina, primary, Marchan, Rosemarie, primary, Stewart, Joanna D., primary, Solbach, Christine, primary, Holmberg, Lars, primary, Edlund, Karolina, primary, Kultima, Hanna Göransson, primary, Rody, Achim, primary, Berglund, Anders, primary, Lambe, Mats, primary, Isaksson, Anders, primary, Botling, Johan, primary, Karn, Thomas, primary, Müller, Volkmar, primary, Gerhold-Ay, Aslihan, primary, Cotarelo, Christina, primary, Sebastian, Martin, primary, Kronenwett, Ralf, primary, Bojar, Hans, primary, Lehr, Hans-Anton, primary, Sahin, Ugur, primary, Koelbl, Heinz, primary, Gehrmann, Mathias, primary, Micke, Patrick, primary, Rahnenführer, Jörg, primary, and Hengstler, Jan G., primary

Published
2023
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22. Marchan_Supplementary Table 6 from Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma

Author

Marchan, Rosemarie, primary, Büttner, Bettina, primary, Lambert, Jörg, primary, Edlund, Karolina, primary, Glaeser, Iris, primary, Blaszkewicz, Meinolf, primary, Leonhardt, Gregor, primary, Marienhoff, Lisa, primary, Kaszta, Darius, primary, Anft, Moritz, primary, Watzl, Carsten, primary, Madjar, Katrin, primary, Grinberg, Marianna, primary, Rempel, Eugen, primary, Hergenröder, Roland, primary, Selinski, Silvia, primary, Rahnenführer, Jörg, primary, Lesjak, Michaela S., primary, Stewart, Joanna D., primary, Cadenas, Cristina, primary, and Hengstler, Jan G., primary

Published
2023
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23. Supplementary Materials and Methods from A Comprehensive Analysis of Human Gene Expression Profiles Identifies Stromal Immunoglobulin κ C as a Compatible Prognostic Marker in Human Solid Tumors

Author

Schmidt, Marcus, primary, Hellwig, Birte, primary, Hammad, Seddik, primary, Othman, Amnah, primary, Lohr, Miriam, primary, Chen, Zonglin, primary, Boehm, Daniel, primary, Gebhard, Susanne, primary, Petry, Ilka, primary, Lebrecht, Antje, primary, Cadenas, Cristina, primary, Marchan, Rosemarie, primary, Stewart, Joanna D., primary, Solbach, Christine, primary, Holmberg, Lars, primary, Edlund, Karolina, primary, Kultima, Hanna Göransson, primary, Rody, Achim, primary, Berglund, Anders, primary, Lambe, Mats, primary, Isaksson, Anders, primary, Botling, Johan, primary, Karn, Thomas, primary, Müller, Volkmar, primary, Gerhold-Ay, Aslihan, primary, Cotarelo, Christina, primary, Sebastian, Martin, primary, Kronenwett, Ralf, primary, Bojar, Hans, primary, Lehr, Hans-Anton, primary, Sahin, Ugur, primary, Koelbl, Heinz, primary, Gehrmann, Mathias, primary, Micke, Patrick, primary, Rahnenführer, Jörg, primary, and Hengstler, Jan G., primary

Published
2023
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24. Supplementary Figures 1-11 from A Comprehensive Analysis of Human Gene Expression Profiles Identifies Stromal Immunoglobulin κ C as a Compatible Prognostic Marker in Human Solid Tumors

Author

Schmidt, Marcus, primary, Hellwig, Birte, primary, Hammad, Seddik, primary, Othman, Amnah, primary, Lohr, Miriam, primary, Chen, Zonglin, primary, Boehm, Daniel, primary, Gebhard, Susanne, primary, Petry, Ilka, primary, Lebrecht, Antje, primary, Cadenas, Cristina, primary, Marchan, Rosemarie, primary, Stewart, Joanna D., primary, Solbach, Christine, primary, Holmberg, Lars, primary, Edlund, Karolina, primary, Kultima, Hanna Göransson, primary, Rody, Achim, primary, Berglund, Anders, primary, Lambe, Mats, primary, Isaksson, Anders, primary, Botling, Johan, primary, Karn, Thomas, primary, Müller, Volkmar, primary, Gerhold-Ay, Aslihan, primary, Cotarelo, Christina, primary, Sebastian, Martin, primary, Kronenwett, Ralf, primary, Bojar, Hans, primary, Lehr, Hans-Anton, primary, Sahin, Ugur, primary, Koelbl, Heinz, primary, Gehrmann, Mathias, primary, Micke, Patrick, primary, Rahnenführer, Jörg, primary, and Hengstler, Jan G., primary

Published
2023
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25. Supplementary Data from Gene Expression–Based Prediction of Neoadjuvant Chemotherapy Response in Early Breast Cancer: Results of the Prospective Multicenter EXPRESSION Trial

Author

Edlund, Karolina, primary, Madjar, Katrin, primary, Lebrecht, Antje, primary, Aktas, Bahriye, primary, Pilch, Henryk, primary, Hoffmann, Gerald, primary, Hofmann, Manfred, primary, Kolberg, Hans-Christian, primary, Boehm, Daniel, primary, Battista, Marco, primary, Seehase, Martina, primary, Stewen, Kathrin, primary, Gebhard, Susanne, primary, Cadenas, Cristina, primary, Marchan, Rosemarie, primary, Brenner, Walburgis, primary, Hasenburg, Annette, primary, Koelbl, Heinz, primary, Solbach, Christine, primary, Gehrmann, Mathias, primary, Tanner, Berno, primary, Weber, Karsten E., primary, Loibl, Sibylle, primary, Sachinidis, Agapios, primary, Rahnenführer, Jörg, primary, Schmidt, Marcus, primary, and Hengstler, Jan G., primary

Published
2023
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26. Supplementary Figures 1 -9 from Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma

Author

Marchan, Rosemarie, primary, Büttner, Bettina, primary, Lambert, Jörg, primary, Edlund, Karolina, primary, Glaeser, Iris, primary, Blaszkewicz, Meinolf, primary, Leonhardt, Gregor, primary, Marienhoff, Lisa, primary, Kaszta, Darius, primary, Anft, Moritz, primary, Watzl, Carsten, primary, Madjar, Katrin, primary, Grinberg, Marianna, primary, Rempel, Eugen, primary, Hergenröder, Roland, primary, Selinski, Silvia, primary, Rahnenführer, Jörg, primary, Lesjak, Michaela S., primary, Stewart, Joanna D., primary, Cadenas, Cristina, primary, and Hengstler, Jan G., primary

Published
2023
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27. Supplementary Tables 1-3 from A Comprehensive Analysis of Human Gene Expression Profiles Identifies Stromal Immunoglobulin κ C as a Compatible Prognostic Marker in Human Solid Tumors

Author

Schmidt, Marcus, primary, Hellwig, Birte, primary, Hammad, Seddik, primary, Othman, Amnah, primary, Lohr, Miriam, primary, Chen, Zonglin, primary, Boehm, Daniel, primary, Gebhard, Susanne, primary, Petry, Ilka, primary, Lebrecht, Antje, primary, Cadenas, Cristina, primary, Marchan, Rosemarie, primary, Stewart, Joanna D., primary, Solbach, Christine, primary, Holmberg, Lars, primary, Edlund, Karolina, primary, Kultima, Hanna Göransson, primary, Rody, Achim, primary, Berglund, Anders, primary, Lambe, Mats, primary, Isaksson, Anders, primary, Botling, Johan, primary, Karn, Thomas, primary, Müller, Volkmar, primary, Gerhold-Ay, Aslihan, primary, Cotarelo, Christina, primary, Sebastian, Martin, primary, Kronenwett, Ralf, primary, Bojar, Hans, primary, Lehr, Hans-Anton, primary, Sahin, Ugur, primary, Koelbl, Heinz, primary, Gehrmann, Mathias, primary, Micke, Patrick, primary, Rahnenführer, Jörg, primary, and Hengstler, Jan G., primary

Published
2023
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28. Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth

Author

Keller, Magdalena, Rohlf, Katharina, Glotzbach, Annika, Leonhardt, Gregor, Lueke, Simon, Derksen, Katharina, Demirci, Özlem, Göcener, Defne, AlWahsh, Mohammad, Lambert, Jörg, Lindskog, Cecilia, Schmidt, Marcus, Brenner, Walburgis, Baumann, Matthias, Zent, Eldar, Zischinsky, Mia-Lisa, Hellwig, Birte, Madjar, Katrin, Rahnenführer, Jörg, Overbeck, Nina, Reinders, Jörg, Cadenas, Cristina, Hengstler, Jan. G. G., Edlund, Karolina, Marchan, Rosemarie, Keller, Magdalena, Rohlf, Katharina, Glotzbach, Annika, Leonhardt, Gregor, Lueke, Simon, Derksen, Katharina, Demirci, Özlem, Göcener, Defne, AlWahsh, Mohammad, Lambert, Jörg, Lindskog, Cecilia, Schmidt, Marcus, Brenner, Walburgis, Baumann, Matthias, Zent, Eldar, Zischinsky, Mia-Lisa, Hellwig, Birte, Madjar, Katrin, Rahnenführer, Jörg, Overbeck, Nina, Reinders, Jörg, Cadenas, Cristina, Hengstler, Jan. G. G., Edlund, Karolina, and Marchan, Rosemarie

Abstract

Background: Intrinsic or acquired resistance to HER2-targeted therapy is often a problem when small molecule tyrosine kinase inhibitors or antibodies are used to treat patients with HER2 positive breast cancer. Therefore, the identification of new targets and therapies for this patient group is warranted. Activated choline metabolism, characterized by elevated levels of choline-containing compounds, has been previously reported in breast cancer. The glycerophosphodiesterase EDI3 (GPCPD1), which hydrolyses glycerophosphocholine to choline and glycerol-3-phosphate, directly influences choline and phospholipid metabolism, and has been linked to cancer-relevant phenotypes in vitro. While the importance of choline metabolism has been addressed in breast cancer, the role of EDI3 in this cancer type has not been explored. Methods: EDI3 mRNA and protein expression in human breast cancer tissue were investigated using publicly-available Affymetrix gene expression microarray datasets (n = 540) and with immunohistochemistry on a tissue microarray (n = 265), respectively. A panel of breast cancer cell lines of different molecular subtypes were used to investigate expression and activity of EDI3 in vitro. To determine whether EDI3 expression is regulated by HER2 signalling, the effect of pharmacological inhibition and siRNA silencing of HER2, as well as the influence of inhibiting key components of signalling cascades downstream of HER2 were studied. Finally, the influence of silencing and pharmacologically inhibiting EDI3 on viability was investigated in vitro and on tumour growth in vivo. Results: In the present study, we show that EDI3 expression is highest in ER-HER2 + human breast tumours, and both expression and activity were also highest in ER-HER2 + breast cancer cell lines. Silencing HER2 using siRNA, as well as inhibiting HER2 signalling with lapatinib decreased EDI3 expression. Pathways downstream of PI3K/Akt/mTOR and GSK3 beta, and transcription factors, including HI

Published
2023
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29. CRUP: a comprehensive framework to predict condition-specific regulatory units

Author

Ramisch, Anna, Heinrich, Verena, Glaser, Laura V., Fuchs, Alisa, Yang, Xinyi, Benner, Philipp, Schöpflin, Robert, Li, Na, Kinkley, Sarah, Römer-Hillmann, Anja, Longinotto, John, Heyne, Steffen, Czepukojc, Beate, Kessler, Sonja M., Kiemer, Alexandra K., Cadenas, Cristina, Arrigoni, Laura, Gasparoni, Nina, Manke, Thomas, Pap, Thomas, Pospisilik, John A., Hengstler, Jan, Walter, Jörn, Meijsing, Sebastiaan H., Chung, Ho-Ryun, and Vingron, Martin

Published
2019
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30. Additional file 1 of Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth

Author

Keller, Magdalena, Rohlf, Katharina, Glotzbach, Annika, Leonhardt, Gregor, Lüke, Simon, Derksen, Katharina, Demirci, Özlem, Göçener, Defne, AlWahsh, Mohammad, Lambert, Jörg, Lindskog, Cecilia, Schmidt, Marcus, Brenner, Walburgis, Baumann, Matthias, Zent, Eldar, Zischinsky, Mia-Lisa, Hellwig, Birte, Madjar, Katrin, Rahnenführer, Jörg, Overbeck, Nina, Reinders, Jörg, Cadenas, Cristina, Hengstler, Jan G., Edlund, Karolina, and Marchan, Rosemarie

Abstract

Additional file 1: Supplementary Figure S1. EDI3 is highly expressed in ER-HER2+ cells and is regulated by HER2. A (left panel), HER2 mRNA expression measured using qRT-PCR. Quantification of A (right panel), HER2 and B, ER protein expression from immunoblotting as represented in Figure 1D. C, Immunofluorescence staining, and D, metabolite levels by NMR in a panel of breast cancer cell lines representing the different breast cancer subtypes. E, HER2 and EDI3 mRNA, and F, protein expression in HCC1954 cells upon HER2 silencing. G, EDI3 and HER2 mRNA expression and H, EDI3, pHER2, and HER2 protein expression in SKBR3 cells after silencing EDI3 with siRNA. I, EDI3 and HER2 mRNA expression and J, EDI3, pHER2, and HER2 protein expression in HCC1954 cells after silencing EDI3 with siRNA. K, Representative Western blots showing EDI3, pHER2 and HER2 protein expression in HCC1954 cells treated with 0.1 µM or 1.0 µM lapatinib for 24, 48, 72 and 96h, with corresponding quantification of protein levels. Data are mean ± SD or mean ± SE for HER2 protein expression in panel A of at least three independent experiments (*, P

Published
2023
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31. Additional file 3 of Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth

Author

Keller, Magdalena, Rohlf, Katharina, Glotzbach, Annika, Leonhardt, Gregor, Lüke, Simon, Derksen, Katharina, Demirci, Özlem, Göçener, Defne, AlWahsh, Mohammad, Lambert, Jörg, Lindskog, Cecilia, Schmidt, Marcus, Brenner, Walburgis, Baumann, Matthias, Zent, Eldar, Zischinsky, Mia-Lisa, Hellwig, Birte, Madjar, Katrin, Rahnenführer, Jörg, Overbeck, Nina, Reinders, Jörg, Cadenas, Cristina, Hengstler, Jan G., Edlund, Karolina, and Marchan, Rosemarie

Abstract

Additional file 3: Supplementary Figure S3. Effect of targeting EDI3 on viability, alone or in combination with lapatinib, in ER-HER2+ and ER+HER2+ breast cancer cell lines. A-B, EDI3 mRNA (left panels) and protein expression (right panels) after silencing EDI3 using siRNA in A, BT474 and B, EFM192A cells. C, Effect of inhibiting HER2 using increasing concentrations of lapatinib on viability in SKBR3, HCC1954, BT474 and EFM192A cells. D-G Influence of silencing EDI3 with siRNA (oligo #2) and inhibiting HER2 with lapatinib (0.01 µM, 0.1 µM and 1 µM), as well as the combined inhibition of both EDI3 and HER2 on viability in D, SKBR3, E, HCC1954, F, BT474 and G, EFM192A cells. H, Effect of inhibiting HER2 using different concentrations of trastuzumab on viability in SKBR3, HCC1954, BT474 and EFM192A cells. I-L Influence of inhibiting EDI3 with siRNA (oligos #1 and #2) and HER2 with trastuzumab (1 µg/ml and 10 µg/ml), as well as the combined inhibition of both EDI3 and HER2 on viability in I, SKBR3, J, HCC1954, K, BT474 and L, EFM192A. Data are mean ± SD (A-C and H) or mean ± SE (D-G and I-L) of at least three independent experiments (*, P

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2023
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32. Additional file 2 of Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth

Author

Keller, Magdalena, Rohlf, Katharina, Glotzbach, Annika, Leonhardt, Gregor, Lüke, Simon, Derksen, Katharina, Demirci, Özlem, Göçener, Defne, AlWahsh, Mohammad, Lambert, Jörg, Lindskog, Cecilia, Schmidt, Marcus, Brenner, Walburgis, Baumann, Matthias, Zent, Eldar, Zischinsky, Mia-Lisa, Hellwig, Birte, Madjar, Katrin, Rahnenführer, Jörg, Overbeck, Nina, Reinders, Jörg, Cadenas, Cristina, Hengstler, Jan G., Edlund, Karolina, and Marchan, Rosemarie

Abstract

Additional file 2: Supplementary Figure S2. GSK3β and mTOR are key proteins in HER2-mediated upregulation of EDI3. A, Quantification of HER2, EDI3 and p-Akt protein expression after inhibiting PI3K with 5 and 10 µM LY294002 for 3 and 7 days in MCF7-NeuT cells. B, Representative Western blot and HER2, EDI3 and p-PKCα/βII protein expression quantification after inhibiting PLCγ with 1 and 3 µM U73122 for 3 and 7 days in MCF7-NeuT cells. C, Representative Western blot and quantification of HER2, EDI3 and p-ERK1/2 protein expression after inhibiting MEK with 5 and 25 µM PD98059 for 3 and 7 days in MCF7-NeuT cells. D, HER2, EDI3 and p-mTOR protein expression after inhibiting mTORC1 with 1 and 3 µM everolimus for 3 and 7 days in MCF7-NeuT cells. E, HER2, EDI3 and p-mTOR protein expression after inhibiting mTORC1 with 1 and 3 µM everolimus for 1, 2 and 3 days in HCC1954 cells. F, HER2, EDI3 and p-mTOR protein expression after inhibiting mTORC1 with 1 and 3 µM everolimus for 1, 2 and 3 days in SKBR3 cells. G, HER2, EDI3 and β-catenin protein expression after inhibiting GSKβ with 1 and 2.5 µM CHIR-99021 for 3 and 7 days in MCF7/NeuT cells. H, HER2, EDI3 and β-catenin protein expression after inhibiting GSKβ with 1 and 2.5 µM CHIR-99021 for 1, 2 and 3 days in HCC1954 cells. I, HER2, EDI3 and β-catenin protein expression after inhibiting GSKβ with 1 and 2.5 µM CHIR-99021 for 1, 2 and 3 days in SKBR3 cells. Graphs D-I are quantification of Western blots exemplified in Fig. 3C-H, respectively. J, EDI3 mRNA expression after inhibiting c-Myc with 5 and 10 µM 10074-G5, K, NFκB with 5 and 10 µM SC75741, or L, KLF5 with 5 and 10 µM SR18662 for 1, 2 and 3 days in SKBR3 cells. Data are mean ± SD of at least three independent experiments (*, P

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2023
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33. Additional file 7 of Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth

Author

Keller, Magdalena, Rohlf, Katharina, Glotzbach, Annika, Leonhardt, Gregor, Lüke, Simon, Derksen, Katharina, Demirci, Özlem, Göçener, Defne, AlWahsh, Mohammad, Lambert, Jörg, Lindskog, Cecilia, Schmidt, Marcus, Brenner, Walburgis, Baumann, Matthias, Zent, Eldar, Zischinsky, Mia-Lisa, Hellwig, Birte, Madjar, Katrin, Rahnenführer, Jörg, Overbeck, Nina, Reinders, Jörg, Cadenas, Cristina, Hengstler, Jan G., Edlund, Karolina, and Marchan, Rosemarie

Abstract

Additional file 7: Supplementary Table S2. List of used reagents including A, QuantiTect primer assays, B, siRNA and shRNA oligos, and C, antibodies.

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2023
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34. Additional file 6 of Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth

Author

Keller, Magdalena, Rohlf, Katharina, Glotzbach, Annika, Leonhardt, Gregor, Lüke, Simon, Derksen, Katharina, Demirci, Özlem, Göçener, Defne, AlWahsh, Mohammad, Lambert, Jörg, Lindskog, Cecilia, Schmidt, Marcus, Brenner, Walburgis, Baumann, Matthias, Zent, Eldar, Zischinsky, Mia-Lisa, Hellwig, Birte, Madjar, Katrin, Rahnenführer, Jörg, Overbeck, Nina, Reinders, Jörg, Cadenas, Cristina, Hengstler, Jan G., Edlund, Karolina, and Marchan, Rosemarie

Abstract

Additional file 6: Supplementary Table S1. EDI3 (GPCPD1) expression in human breast cancer tissue was evaluated in publicly available Affymetrix HG U133 Plus 2.0 gene expression microarray dataset that were downloaded from the Gene Expression Omnibus webportal (GEO) together with available clinicopathological data.

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2023
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35. Additional file 8 of Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth

Author

Keller, Magdalena, Rohlf, Katharina, Glotzbach, Annika, Leonhardt, Gregor, Lüke, Simon, Derksen, Katharina, Demirci, Özlem, Göçener, Defne, AlWahsh, Mohammad, Lambert, Jörg, Lindskog, Cecilia, Schmidt, Marcus, Brenner, Walburgis, Baumann, Matthias, Zent, Eldar, Zischinsky, Mia-Lisa, Hellwig, Birte, Madjar, Katrin, Rahnenführer, Jörg, Overbeck, Nina, Reinders, Jörg, Cadenas, Cristina, Hengstler, Jan G., Edlund, Karolina, and Marchan, Rosemarie

Abstract

Additional file 8: Supplementary Table S3. Association of EDI3 expression for the three probesets on the Affymetrix HG U133 Plus 2.0 array and available clinicopathological parameters shown for A, the six datasets combined, as well as separately for B, GSE16446, C, GSE19615, D, GSE28844, E, GSE32646, F, GSE6532, and G, GSE9195. P value from the Mann Whitney or Kruskal-Wallis U test.

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2023
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36. Additional file 5 of Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth

Author

Keller, Magdalena, Rohlf, Katharina, Glotzbach, Annika, Leonhardt, Gregor, Lüke, Simon, Derksen, Katharina, Demirci, Özlem, Göçener, Defne, AlWahsh, Mohammad, Lambert, Jörg, Lindskog, Cecilia, Schmidt, Marcus, Brenner, Walburgis, Baumann, Matthias, Zent, Eldar, Zischinsky, Mia-Lisa, Hellwig, Birte, Madjar, Katrin, Rahnenführer, Jörg, Overbeck, Nina, Reinders, Jörg, Cadenas, Cristina, Hengstler, Jan G., Edlund, Karolina, and Marchan, Rosemarie

Abstract

Additional file 5: Supplemental Figure S5. Inducibly silencing EDI3 inhibits colony formation and cell viability. A, Representative images (top) and corresponding quantification (bottom) of colony number (left) and size (right) formed by HCC1954 shNEG and HCC1954 shEDI3 (oligos shEDI3 #1, #2, #3) cells treated with 0 or 0.1 µg/ml doxycycline. B, Viability (RFU) after treating HCC1954 shNEG and HCC1954 shEDI3 (oligos shEDI3 #1, #2) with 0.1 or 1 µg/ml doxycycline. All in vitro data are mean ± SD of three independent experiments. (*, P < 0.05; **, P < 0.01; ***, P < 0.001). RFU, relative fluorescence units.

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2023
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37. Additional file 4 of Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth

Author

Keller, Magdalena, Rohlf, Katharina, Glotzbach, Annika, Leonhardt, Gregor, Lüke, Simon, Derksen, Katharina, Demirci, Özlem, Göçener, Defne, AlWahsh, Mohammad, Lambert, Jörg, Lindskog, Cecilia, Schmidt, Marcus, Brenner, Walburgis, Baumann, Matthias, Zent, Eldar, Zischinsky, Mia-Lisa, Hellwig, Birte, Madjar, Katrin, Rahnenführer, Jörg, Overbeck, Nina, Reinders, Jörg, Cadenas, Cristina, Hengstler, Jan G., Edlund, Karolina, and Marchan, Rosemarie

Abstract

Additional file 4: Supplementary Figure S4. Inhibiting EDI3 with dipyridamole, alone or in combination with HER2-targeting therapy, in ER-HER2+ tumors in mice. A-D EDI3 activity in percent after treatment with dipyridamole at different concentrations in A, HCC1954 B, SKBR3, C, BT474 and D, EFM192 cells. E, Cell viability in percent of vehicle control after treatment with different concentrations of dipyridamole in SKBR3, HCC1954, BT474 and EFM192A cells (upper panel) and EC50-values with corresponding 95% confidence intervals (CI) (lower panel). F, Concentration of dipyridamole in plasma after a single oral dose of 120 mg/kg dipyridamole in mice over time. G, Mouse weight (grams) after treatment with dipyridamole, lapatinib and the combination for up to 4 weeks. H, Images of CD1 nude mice with tumors encircled, after 4-week treatment of vehicle, dipyridamole, lapatinib and the combination of both. I, Plasma and tumor concentrations (µM) of dipyridamole (upper panel) and lapatinib (lower panel) after treatment with each compound alone or in combination (D+L). Data (A-E) are mean ± SD of three independent experiments; mean ± SD of three CD1 mice (F); mean ± SD 5 to 6 mice (G); and representative images of 4 mice per condition H. D+L (combined dipyridamole and lapatinib treatment); BQL (below quantification limit); EC50 (half maximal effective concentration).

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2023
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38. Adverse outcome pathways: opportunities, limitations and open questions

Author

Leist, Marcel, Ghallab, Ahmed, Graepel, Rabea, Marchan, Rosemarie, Hassan, Reham, Bennekou, Susanne Hougaard, Limonciel, Alice, Vinken, Mathieu, Schildknecht, Stefan, Waldmann, Tanja, Danen, Erik, van Ravenzwaay, Ben, Kamp, Hennicke, Gardner, Iain, Godoy, Patricio, Bois, Frederic Y., Braeuning, Albert, Reif, Raymond, Oesch, Franz, Drasdo, Dirk, Höhme, Stefan, Schwarz, Michael, Hartung, Thomas, Braunbeck, Thomas, Beltman, Joost, Vrieling, Harry, Sanz, Ferran, Forsby, Anna, Gadaleta, Domenico, Fisher, Ciarán, Kelm, Jens, Fluri, David, Ecker, Gerhard, Zdrazil, Barbara, Terron, Andrea, Jennings, Paul, van der Burg, Bart, Dooley, Steven, Meijer, Annemarie H., Willighagen, Egon, Martens, Marvin, Evelo, Chris, Mombelli, Enrico, Taboureau, Olivier, Mantovani, Alberto, Hardy, Barry, Koch, Bjorn, Escher, Sylvia, van Thriel, Christoph, Cadenas, Cristina, Kroese, D., van de Water, Bob, and Hengstler, Jan G.

Published
2017
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43. Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

Author

Godoy, Patricio, Widera, Agata, Schmidt-Heck, Wolfgang, Campos, Gisela, Meyer, Christoph, Cadenas, Cristina, Reif, Raymond, Stöber, Regina, Hammad, Seddik, Pütter, Larissa, Gianmoena, Kathrin, Marchan, Rosemarie, Ghallab, Ahmed, Edlund, Karolina, Nüssler, Andreas, Thasler, Wolfgang E., Damm, Georg, Seehofer, Daniel, Weiss, Thomas S., Dirsch, Olaf, Dahmen, Uta, Gebhardt, Rolf, Chaudhari, Umesh, Meganathan, Kesavan, Sachinidis, Agapios, Kelm, Jens, Hofmann, Ute, Zahedi, René P., Guthke, Reinhard, Blüthgen, Nils, Dooley, Steven, and Hengstler, Jan G.

Published
2016
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44. The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer

Author

Lohr, Miriam, Edlund, Karolina, Botling, Johan, Hammad, Seddik, Hellwig, Birte, Othman, Amnah, Berglund, Anders, Lambe, Mats, Holmberg, Lars, Ekman, Simon, Bergqvist, Michael, Pontén, Fredrik, Cadenas, Cristina, Marchan, Rosemarie, Hengstler, Jan G., Rahnenführer, Jörg, and Micke, Patrick

Published
2013
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45. Impact of Biological and Lifestyle Factors on Cognitive Aging and Work Ability in the Dortmund Vital Study: Protocol of an Interdisciplinary, Cross-sectional, and Longitudinal Study

Author

Gajewski, Patrick D, primary, Getzmann, Stephan, additional, Bröde, Peter, additional, Burke, Michael, additional, Cadenas, Cristina, additional, Capellino, Silvia, additional, Claus, Maren, additional, Genç, Erhan, additional, Golka, Klaus, additional, Hengstler, Jan G, additional, Kleinsorge, Thomas, additional, Marchan, Rosemarie, additional, Nitsche, Michael A, additional, Reinders, Jörg, additional, van Thriel, Christoph, additional, Watzl, Carsten, additional, and Wascher, Edmund, additional

Published
2022
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47. The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds

Author

Brecklinghaus, Tim, primary, Albrecht, Wiebke, additional, Kappenberg, Franziska, additional, Duda, Julia, additional, Vartak, Nachiket, additional, Edlund, Karolina, additional, Marchan, Rosemarie, additional, Ghallab, Ahmed, additional, Cadenas, Cristina, additional, Günther, Georgia, additional, Leist, Marcel, additional, Zhang, Mian, additional, Gardner, Iain, additional, Reinders, Jörg, additional, Russel, Frans GM., additional, Foster, Alison J., additional, Williams, Dominic P., additional, Damle-Vartak, Amruta, additional, Grandits, Melanie, additional, Ecker, Gerhard, additional, Kittana, Naim, additional, Rahnenführer, Jörg, additional, and Hengstler, Jan G., additional

Published
2022
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49. The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity

Author

Campos, Gisela, Schmidt-Heck, Wolfgang, Ghallab, Ahmed, Rochlitz, Katharina, Pütter, Larissa, Medinas, Danilo B., Hetz, Claudio, Widera, Agata, Cadenas, Cristina, Begher-Tibbe, Brigitte, Reif, Raymond, Günther, Georgia, Sachinidis, Agapios, Hengstler, Jan G., and Godoy, Patricio

Published
2014
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50. Impact of Biological and Lifestyle Factors on Cognitive Aging and Work Ability in the Dortmund Vital Study: Protocol of an Interdisciplinary, Cross-sectional, and Longitudinal Study (Preprint)

Author

Gajewski, Patrick D, primary, Getzmann, Stephan, additional, Bröde, Peter, additional, Burke, Michael, additional, Cadenas, Cristina, additional, Capellino, Silvia, additional, Claus, Maren, additional, Genç, Erhan, additional, Golka, Klaus, additional, Hengstler, Jan G, additional, Kleinsorge, Thomas, additional, Marchan, Rosemarie, additional, Nitsche, Michael A, additional, Reinders, Jörg, additional, van Thriel, Christoph, additional, Watzl, Carsten, additional, and Wascher, Edmund, additional

Published
2021
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