22 results on '"Caers, Jelle"'
Search Results
2. Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
- Author
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Attardo, Geoffrey M, Abd-Alla, Adly MM, Acosta-Serrano, Alvaro, Allen, James E, Bateta, Rosemary, Benoit, Joshua B, Bourtzis, Kostas, Caers, Jelle, Caljon, Guy, Christensen, Mikkel B, Farrow, David W, Friedrich, Markus, Hua-Van, Aurélie, Jennings, Emily C, Larkin, Denis M, Lawson, Daniel, Lehane, Michael J, Lenis, Vasileios P, Lowy-Gallego, Ernesto, Macharia, Rosaline W, Malacrida, Anna R, Marco, Heather G, Masiga, Daniel, Maslen, Gareth L, Matetovici, Irina, Meisel, Richard P, Meki, Irene, Michalkova, Veronika, Miller, Wolfgang J, Minx, Patrick, Mireji, Paul O, Ometto, Lino, Parker, Andrew G, Rio, Rita, Rose, Clair, Rosendale, Andrew J, Rota-Stabelli, Omar, Savini, Grazia, Schoofs, Liliane, Scolari, Francesca, Swain, Martin T, Takáč, Peter, Tomlinson, Chad, Tsiamis, George, Van Den Abbeele, Jan, Vigneron, Aurelien, Wang, Jingwen, Warren, Wesley C, Waterhouse, Robert M, Weirauch, Matthew T, Weiss, Brian L, Wilson, Richard K, Zhao, Xin, and Aksoy, Serap
- Subjects
Biological Sciences ,Genetics ,Vector-Borne Diseases ,Biotechnology ,Infectious Diseases ,Infection ,Good Health and Well Being ,Animals ,DNA Transposable Elements ,Drosophila melanogaster ,Female ,Gene Expression Regulation ,Genes ,Insect ,Genes ,X-Linked ,Genome ,Insect ,Genomics ,Geography ,Insect Proteins ,Insect Vectors ,Male ,Mutagenesis ,Insertional ,Phylogeny ,Repetitive Sequences ,Nucleic Acid ,Sequence Homology ,Amino Acid ,Synteny ,Trypanosoma ,Tsetse Flies ,Wolbachia ,Tsetse ,Trypanosomiasis ,Hematophagy ,Lactation ,Disease ,Neglected ,Symbiosis ,Environmental Sciences ,Information and Computing Sciences ,Bioinformatics - Abstract
BackgroundTsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse flies are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate viviparity), a vertebrate blood-specific diet by both sexes, and obligate bacterial symbiosis. This work describes the comparative analysis of six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans, G. pallidipes, G. austeni), Palpalis (G. palpalis, G. fuscipes), and Fusca (G. brevipalpis) which represent different habitats, host preferences, and vectorial capacity.ResultsGenomic analyses validate established evolutionary relationships and sub-genera. Syntenic analysis of Glossina relative to Drosophila melanogaster shows reduced structural conservation across the sex-linked X chromosome. Sex-linked scaffolds show increased rates of female-specific gene expression and lower evolutionary rates relative to autosome associated genes. Tsetse-specific genes are enriched in protease, odorant-binding, and helicase activities. Lactation-associated genes are conserved across all Glossina species while male seminal proteins are rapidly evolving. Olfactory and gustatory genes are reduced across the genus relative to other insects. Vision-associated Rhodopsin genes show conservation of motion detection/tracking functions and variance in the Rhodopsin detecting colors in the blue wavelength ranges.ConclusionsExpanded genomic discoveries reveal the genetics underlying Glossina biology and provide a rich body of knowledge for basic science and disease control. They also provide insight into the evolutionary biology underlying novel adaptations and are relevant to applied aspects of vector control such as trap design and discovery of novel pest and disease control strategies.
- Published
- 2019
3. The Glossina Genome Cluster: Comparative Genomic Analysis of the Vectors of African Trypanosomes
- Author
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Attardo, Geoffrey M, Abd-Alla, Adly MM, Acosta-Serrano, Alvaro, Allen, James E, Bateta, Rosemary, Benoit, Joshua B, Bourtzis, Kostas, Caers, Jelle, Caljon, Guy, Christensen, Mikkel B, Farrow, David W, Friedrich, Markus, Hua-Van, Aurélie, Jennings, Emily C, Larkin, Denis M, Lawson, Daniel, Lehane, Michael J, Lenis, Vasileios P, Lowy-Gallego, Ernesto, Macharia, Rosaline W, Malacrida, Anna R, Marco, Heather G, Masiga, Daniel, Maslen, Gareth L, Matetovici, Irina, Meisel, Richard P, Meki, Irene, Michalkova, Veronika, Miller, Wolfgang J, Minx, Patrick, Mireji, Paul O, Ometto, Lino, Parker, Andrew G, Rio, Rita, Rose, Clair, Rosendale, Andrew J, Rota-Stabelli, Omar, Savini, Grazia, Schoofs, Liliane, Scolari, Francesca, Swain, Martin T, Takáč, Peter, Tomlinson, Chad, Tsiamis, George, Van Den Abbeele, Jan, Vigneron, Aurelien, Wang, Jingwen, Warren, Wesley C, Waterhouse, Robert M, Weirauch, Matthew T, Weiss, Brian L, Wilson, Richard K, Zhao, Xin, and Aksoy, Serap
- Subjects
Biological Sciences ,Genetics ,Infectious Diseases ,Vector-Borne Diseases ,Biotechnology ,Infection ,Good Health and Well Being - Abstract
Background: Tsetse flies (Glossina sp.) are the sole vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate viviparity), a vertebrate blood specific diet by both sexes and obligate bacterial symbiosis. This work describes comparative analysis of six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans (G.m. morsitans), G. pallidipes, G. austeni), Palpalis (G. palpalis, G. fuscipes) and Fusca (G. brevipalpis) which represent different habitats, host preferences and vectorial capacity. Results: Genomic analyses validate established evolutionary relationships and sub-genera. Syntenic analysis of Glossina relative to Drosophila melanogaster shows reduced structural conservation across the sex-linked X chromosome. Sex linked scaffolds show increased rates of female specific gene expression and lower evolutionary rates relative to autosome associated genes. Tsetse specific genes are enriched in protease, odorant binding and helicase activities. Lactation associated genes are conserved across all Glossina species while male seminal proteins are rapidly evolving. Olfactory and gustatory genes are reduced across the genus relative to other characterized insects. Vision associated Rhodopsin genes show conservation of motion detection/tracking functions and significant variance in the Rhodopsin detecting colors in the blue wavelength ranges. Conclusions: Expanded genomic discoveries reveal the genetics underlying Glossina biology and provide a rich body of knowledge for basic science and disease control. They also provide insight into the evolutionary biology underlying novel adaptations and are relevant to applied aspects of vector control such as trap design and discovery of novel pest and disease control strategies.
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- 2019
4. Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis
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Initiative, International Glossina Genome, Attardo, Geoffrey M, Abila, Patrick P, Auma, Joanna E, Baumann, Aaron A, Benoit, Joshua B, Brelsfoard, Corey L, Ribeiro, José MC, Cotton, James A, Pham, Daphne QD, Darby, Alistair C, Van Den Abbeele, Jan, Denlinger, David L, Field, Linda M, Nyanjom, Steven RG, Gaunt, Michael W, Geiser, Dawn L, Gomulski, Ludvik M, Haines, Lee R, Hansen, Immo A, Jones, Jeffery W, Kibet, Caleb K, Kinyua, Johnson K, Larkin, Denis M, Lehane, Michael J, Rio, Rita VM, Macdonald, Sandy J, Macharia, Rosaline W, Malacrida, Anna R, Marco, Heather G, Marucha, Kevin K, Masiga, Daniel K, Meuti, Megan E, Mireji, Paul O, Obiero, George FO, Koekemoer, Jacobus JO, Okoro, Chinyere K, Omedo, Irene A, Osamor, Victor C, Balyeidhusa, Apollo SP, Peyton, Justin T, Price, David P, Quail, Michael A, Ramphul, Urvashi N, Rawlings, Neil D, Riehle, Michael A, Robertson, Hugh M, Sanders, Mandy J, Scott, Maxwell J, Dashti, Zahra Jalali Sefid, Snyder, Anna K, Srivastava, Tulika P, Stanley, Eleanor J, Swain, Martin T, Hughes, Daniel ST, Tarone, Aaron M, Taylor, Todd D, Telleria, Erich L, Thomas, Gavin H, Walshe, Deirdre P, Wilson, Richard K, Winzerling, Joy J, Acosta-Serrano, Alvaro, Aksoy, Serap, Arensburger, Peter, Aslett, Martin, Bateta, Rosemary, Benkahla, Alia, Berriman, Matthew, Bourtzis, Kostas, Caers, Jelle, Caljon, Guy, Christoffels, Alan, Falchetto, Marco, Friedrich, Markus, Fu, Shuhua, Gäde, Gerd, Githinji, George, Gregory, Richard, Hall, Neil, Harkins, Gordon, Hattori, Masahira, Hertz-Fowler, Christiane, Hide, Winston, Hu, Wanqi, Imanishi, Tadashi, Inoue, Noboru, Jonas, Mario, Kawahara, Yoshihiro, Koffi, Mathurin, Kruger, Adele, Lawson, Daniel, Lehane, Stella, Lehväslaiho, Heikki, Luiz, Thiago, Makgamathe, Mmule, Malele, Imna, Manangwa, Oliver, Manga, Lucien, and Megy, Karyn
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Vector-Borne Diseases ,Genetics ,Prevention ,Infectious Diseases ,Biotechnology ,2.2 Factors relating to the physical environment ,Aetiology ,Infection ,Good Health and Well Being ,Animals ,Blood ,Feeding Behavior ,Female ,Genes ,Insect ,Genome ,Insect ,Insect Proteins ,Insect Vectors ,Microbiota ,Molecular Sequence Annotation ,Molecular Sequence Data ,Reproduction ,Salivary Glands ,Sensation ,Sequence Analysis ,DNA ,Symbiosis ,Trypanosoma ,Trypanosomiasis ,African ,Tsetse Flies ,Wolbachia ,International Glossina Genome Initiative ,General Science & Technology - Abstract
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
- Published
- 2014
5. System-wide mapping of neuropeptide-GPCR interactions inC. elegans
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Beets, Isabel, primary, Zels, Sven, additional, Vandewyer, Elke, additional, Demeulemeester, Jonas, additional, Caers, Jelle, additional, Baytemur, Esra, additional, Schafer, William R., additional, Vértes, Petra E., additional, Mirabeau, Olivier, additional, and Schoofs, Liliane, additional
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- 2022
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6. Peptidomics of Neuropeptidergic Tissues of the Tsetse Fly Glossina morsitans morsitans
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Caers, Jelle, Boonen, Kurt, Van Den Abbeele, Jan, Van Rompay, Liesbeth, Schoofs, Liliane, and Van Hiel, Matthias B.
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- 2015
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7. New genetic regulators question relevance of abundant yolk protein production in C. elegans
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Van Rompay, Liesbeth, Borghgraef, Charline, Beets, Isabel, Caers, Jelle, and Temmerman, Liesbet
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- 2015
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8. Insect omics research coming of age
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Boerjan, Bart, Cardoen, Dries, Verdonck, Rik, Caers, Jelle, and Schoofs, Liliane
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Nucleotide sequencing -- Methods ,Proteomics -- Research ,DNA sequencing -- Methods ,Drosophila -- Genetic aspects ,Zoology and wildlife conservation - Abstract
As more and more insect genomes are fully sequenced and annotated, omics technologies, including transcriptomic, proteomic, peptidomics, and metobolomic profiling, as well as bioinformatics, can be used to exploit this huge amount of sequence information for the study of different biological aspects of insect model organisms. Omics experiments are an elegant way to deliver candidate genes, the function of which can be further explored by genetic tools for functional inactivation or overexpression of the genes of interest. Such tools include mainly RNA interference and are currently being developed in diverse insect species. In this manuscript, we have reviewed how omics technologies were integrated and applied in insect biology. Key words: insects, functional genomics, peptidomics, proteomics, genetics. A mesure que de plus en plus de genomes d'insectes sont completement sequences et annotes, les technologies << omiques >>, en particulier la transcriptomique, la proteomique, la peptidomique et le profilage metobolomique, de meme que la bioinformatique, peuvent servir a exploiter cet immense quantite d'information sequencee pour l'etude de differents aspects biologiques des organismes modeles entomologiques. Les experiences omiques representent une voie elegante pour fournir des genes candidats dont la fonction peut etre encore exploree plus avant a l' aide des outils genetiques d'inactivation fonctionnelle ou de surexpression des genes retenus. Ces outils comprennent surtout l'ARN interferent et sont en train d'etre mis au point pour diverses especes d'insectes. Nous passons en revue dans notre presentation comment les technologies omiques ont ete integrees dans la biologie des insectes et comment on les a utilisees. Mots-cles: insectes, genomique fonctionnelle, peptidomique, proteomique, genetique. [Traduit par la Redaction], Introduction With the start of the 21st century, we have entered the postgenomic era in biological research. The availability of an ever increasing number of reference genome sequences, transcriptomes, and [...]
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- 2012
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9. Additional file 13: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
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Attardo, Geoffrey, Adly Abd-Alla, Acosta-Serrano, Alvaro, Allen, James, Bateta, Rosemary, Benoit, Joshua, Bourtzis, Kostas, Caers, Jelle, Caljon, Guy, Christensen, Mikkel, Farrow, David, Friedrich, Markus, AurĂŠlie Hua-Van, Jennings, Emily, Larkin, Denis, Lawson, Daniel, Lehane, Michael, Lenis, Vasileios, Lowy-Gallego, Ernesto, Macharia, Rosaline, Malacrida, Anna, Marco, Heather, Masiga, Daniel, Maslen, Gareth, Matetovici, Irina, Meisel, Richard, Meki, Irene, Michalkova, Veronika, Miller, Wolfgang, Minx, Patrick, Mireji, Paul, Ometto, Lino, Parker, Andrew, Rio, Rita, Rose, Clair, Rosendale, Andrew, Rota-Stabelli, Omar, Savini, Grazia, Schoofs, Liliane, Scolari, Francesca, Swain, Martin, TakĂĄÄ, Peter, Tomlinson, Chad, Tsiamis, George, Abbeele, Jan, Vigneron, Aurelien, Jingwen Wang, Warren, Wesley, Waterhouse, Robert, Weirauch, Matthew, Weiss, Brian, Wilson, Richard, Zhao, Xin, and Aksoy, Serap
- Abstract
Review history. (DOCX 31 kb)
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- 2019
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10. The Glossina Genome Cluster: Comparative Genomic Analysis of the Vectors of African Trypanosomes
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Attardo, Geoffrey Michael, primary, Abd-Alla, Adly M.M., additional, Acosta-Serrano, Alvaro, additional, Allen, James E, additional, Bateta, Rosemary, additional, Benoit, Joshua, additional, Bourtzis, Kostas, additional, Caers, Jelle, additional, Caljon, Guy, additional, Christensen, Mikkel B., additional, Farrow, David W., additional, Friedrich, Markus, additional, Hua-Van, Aurélie, additional, Jennings, Emily C., additional, Larkin, Denis M, additional, Lawson, Daniel, additional, Lehane, Michael J., additional, Lenis, Vasileios P., additional, Lowy-Gallego, Ernesto, additional, Macharia, Rosaline W., additional, Malacrida, Anna R., additional, Marco, Heather G., additional, Masiga, Daniel, additional, Maslen, Gareth L., additional, Matetovici, Irina, additional, Meisel, Richard P., additional, Meki, Irene, additional, Michalkova, Veronika, additional, Miller, Wolfgang J., additional, Minx, Patrick, additional, Mireji, Paul O., additional, Ometto, Lino, additional, Parker, Andrew G., additional, Rio, Rita, additional, Rose, Clair, additional, Rosendale, Andrew J., additional, Rota Stabelli, Omar, additional, Savini, Grazia, additional, Schoofs, Liliane, additional, Scolari, Francesca, additional, Swain, Martin T., additional, Takáč, Peter, additional, Tomlinson, Chad, additional, Tsiamis, George, additional, Van Den Abbeele, Jan, additional, Vigneron, Aurélien, additional, Wang, Jingwen, additional, Warren, Wesley C., additional, Waterhouse, Robert M., additional, Weirauch, Matthew T., additional, Weiss, Brian L., additional, Wilson, Richard K., additional, Zhao, Xin, additional, and Aksoy, Serap, additional
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- 2019
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11. Characterization of a neuropeptide F receptor in the tsetse fly, Glossina morsitans morsitans
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Caers, Jelle, primary, Van Hiel, Matthias B., additional, Peymen, Katleen, additional, Zels, Sven, additional, Van Rompay, Liesbeth, additional, Van Den Abbeele, Jan, additional, Schoofs, Liliane, additional, and Beets, Isabel, additional
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- 2016
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12. Comparative genomic analysis of six Glossinagenomes, vectors of African trypanosomes
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Attardo, Geoffrey, Abd-Alla, Adly, Acosta-Serrano, Alvaro, Allen, James, Bateta, Rosemary, Benoit, Joshua, Bourtzis, Kostas, Caers, Jelle, Caljon, Guy, Christensen, Mikkel, Farrow, David, Friedrich, Markus, Hua-Van, Aurélie, Jennings, Emily, Larkin, Denis, Lawson, Daniel, Lehane, Michael, Lenis, Vasileios, Lowy-Gallego, Ernesto, Macharia, Rosaline, Malacrida, Anna, Marco, Heather, Masiga, Daniel, Maslen, Gareth, Matetovici, Irina, Meisel, Richard, Meki, Irene, Michalkova, Veronika, Miller, Wolfgang, Minx, Patrick, Mireji, Paul, Ometto, Lino, Parker, Andrew, Rio, Rita, Rose, Clair, Rosendale, Andrew, Rota-Stabelli, Omar, Savini, Grazia, Schoofs, Liliane, Scolari, Francesca, Swain, Martin, Takáč, Peter, Tomlinson, Chad, Tsiamis, George, Abbeele, Jan, Vigneron, Aurelien, Wang, Jingwen, Warren, Wesley, Waterhouse, Robert, Weirauch, Matthew, Weiss, Brian, Wilson, Richard, Zhao, Xin, and Aksoy, Serap
- Abstract
Tsetse flies (Glossinasp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse flies are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate viviparity), a vertebrate blood-specific diet by both sexes, and obligate bacterial symbiosis. This work describes the comparative analysis of six Glossinagenomes representing three sub-genera: Morsitans(G. morsitans morsitans, G. pallidipes, G. austeni), Palpalis(G. palpalis, G. fuscipes), and Fusca(G. brevipalpis) which represent different habitats, host preferences, and vectorial capacity. Genomic analyses validate established evolutionary relationships and sub-genera. Syntenic analysis of Glossinarelative to Drosophila melanogastershows reduced structural conservation across the sex-linked X chromosome. Sex-linked scaffolds show increased rates of female-specific gene expression and lower evolutionary rates relative to autosome associated genes. Tsetse-specific genes are enriched in protease, odorant-binding, and helicase activities. Lactation-associated genes are conserved across all Glossinaspecies while male seminal proteins are rapidly evolving. Olfactory and gustatory genes are reduced across the genus relative to other insects. Vision-associated Rhodopsin genes show conservation of motion detection/tracking functions and variance in the Rhodopsin detecting colors in the blue wavelength ranges. Expanded genomic discoveries reveal the genetics underlying Glossinabiology and provide a rich body of knowledge for basic science and disease control. They also provide insight into the evolutionary biology underlying novel adaptations and are relevant to applied aspects of vector control such as trap design and discovery of novel pest and disease control strategies.
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- 2019
- Full Text
- View/download PDF
13. Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis : International Glossina Genome Initiative
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Watanabe, Junichi, Hattori, Masahira, Berriman, Matthew, Lehane, Michael, Hall, Neil, Solano, Philippe, Aksoy, Serap, Hide, Winston, Touré, Yeya, Attardo, Geoffrey, Darby, Alistair, Toyoda, Atsushi, Hertz-Fowler, Christiane, Larkin, Denis, Cotton, James, Sanders, Mandy, Swain, Martin, Quail, Michael, Inoue, Noboru, Ravel, Sophie, Taylor, Todd, Srivastava, Tulika, Sharma, Vineet, Warren, Wesley, Wilson, Richard, Suzuki, Yutaka, Lawson, Daniel, Hughes, Daniel, Megy, Karyn, Masiga, Daniel, Mireji, Paul, Hansen, Immo, Van Den Abbeele, Jan, Benoit, Joshua, Bourtzis, Kostas, Obiero, George, Robertson, Hugh, Jones, Jeffery, Zhou, Jing-Jiang, Field, Linda, Friedrich, Markus, Nyanjom, Steven, Telleria, Erich, Caljon, Guy, Ribeiro, José, Acosta-Serrano, Alvaro, Ooi, Cher-Pheng, Rose, Clair, Price, David, Haines, Lee, Christoffels, Alan, Sim, Cheolho, Pham, Daphne, Denlinger, David, Geiser, Dawn, Omedo, Irene, Winzerling, Joy, Peyton, Justin, Marucha, Kevin, Jonas, Mario, Meuti, Megan, Rawlings, Neil, Zhang, Qirui, Macharia, Rosaline, Michalkova, Veronika, Dashti, Zahra, Baumann, Aaron, Gäde, Gerd, Marco, Heather, Caers, Jelle, Schoofs, Liliane, Riehle, Michael, Hu, Wanqi, Tu, Zhijian, Tarone, Aaron, Malacrida, Anna, Kibet, Caleb, Scolari, Francesca, Koekemoer, Jacobus, Willis, Judith, Gomulski, Ludvik, Falchetto, Marco, Scott, Maxwell, Fu, Shuhua, Sze, Sing-Hoi, Luiz, Thiago, Weiss, Brian, Walshe, Deirdre, Wang, Jingwen, Wamalwa, Mark, Mwangi, Sarah, Ramphul, Urvashi, Snyder, Anna, Brelsfoard, Corey, Thomas, Gavin, Tsiamis, George, Arensburger, Peter, Rio, Rita, Macdonald, Sandy, Panji, Sumir, Kruger, Adele, Benkahla, Alia, Balyeidhusa, Apollo, Msangi, Atway, Okoro, Chinyere, Stephens, Dawn, Stanley, Eleanor, Mpondo, Feziwe, Wamwiri, Florence, Mramba, Furaha, Siwo, Geoffrey, Githinji, George, Harkins, Gordon, Murilla, Grace, Lehväslaiho, Heikki, Malele, Imna, Auma, Joanna, Kinyua, Johnson, Ouma, Johnson, Okedi, Loyce, Manga, Lucien, Aslett, Martin, Koffi, Mathurin, Gaunt, Michael, Makgamathe, Mmule, Mulder, Nicola, Manangwa, Oliver, Abila, Patrick, Wincker, Patrick, Gregory, Richard, Bateta, Rosemary, Sakate, Ryuichi, Ommeh, Sheila, Lehane, Stella, Imanishi, Tadashi, Osamor, Victor, and Kawahara, Yoshihiro
- Abstract
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology. ispartof: Science vol:344 issue:6182 pages:380-386 ispartof: location:United States status: published
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- 2014
14. Molecular characterization of a short neuropeptide F signaling system in the tsetse fly, Glossina morsitans morsitans
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Caers, Jelle, primary, Peymen, Katleen, additional, Van Hiel, Matthias B., additional, Van Rompay, Liesbeth, additional, Van Den Abbeele, Jan, additional, Schoofs, Liliane, additional, and Beets, Isabel, additional
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- 2016
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15. Characterization and pharmacological analysis of two adipokinetic hormone receptor variants of the tsetse fly, Glossina morsitans morsitans
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Caers, Jelle, primary, Janssen, Tom, additional, Van Rompay, Liesbeth, additional, Broeckx, Valérie, additional, Van Den Abbeele, Jan, additional, Gäde, Gerd, additional, Schoofs, Liliane, additional, and Beets, Isabel, additional
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- 2016
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16. Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay
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Caers, Jelle, primary, Peymen, Katleen, primary, Suetens, Nick, primary, Temmerman, Liesbet, primary, Janssen, Tom, primary, Schoofs, Liliane, primary, and Beets, Isabel, primary
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- 2014
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17. Structure–activity studies of Drosophila adipokinetic hormone (AKH) by a cellular expression system of dipteran AKH receptors
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Caers, Jelle, primary, Peeters, Lise, additional, Janssen, Tom, additional, De Haes, Wouter, additional, Gäde, Gerd, additional, and Schoofs, Liliane, additional
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- 2012
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18. More than two decades of research on insect neuropeptide GPCRs: an overview
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Caers, Jelle, primary, Verlinden, Heleen, additional, Zels, Sven, additional, Vandersmissen, Hans Peter, additional, Vuerinckx, Kristel, additional, and Schoofs, Liliane, additional
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- 2012
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19. An experimental test of the role of environmental temperature variability on ectotherm molecular, physiological and life-history traits: Implications for global warming
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Folguera, Guillermo, primary, Bastías, Daniel A., additional, Caers, Jelle, additional, Rojas, José M., additional, Piulachs, Maria-Dolors, additional, Bellés, Xavier, additional, and Bozinovic, Francisco, additional
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- 2011
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20. Additional file 2: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
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Attardo, Geoffrey, Adly Abd-Alla, Acosta-Serrano, Alvaro, Allen, James, Bateta, Rosemary, Benoit, Joshua, Bourtzis, Kostas, Caers, Jelle, Caljon, Guy, Christensen, Mikkel, Farrow, David, Friedrich, Markus, AurĂŠlie Hua-Van, Jennings, Emily, Larkin, Denis, Lawson, Daniel, Lehane, Michael, Lenis, Vasileios, Lowy-Gallego, Ernesto, Macharia, Rosaline, Malacrida, Anna, Marco, Heather, Masiga, Daniel, Maslen, Gareth, Matetovici, Irina, Meisel, Richard, Meki, Irene, Michalkova, Veronika, Miller, Wolfgang, Minx, Patrick, Mireji, Paul, Ometto, Lino, Parker, Andrew, Rio, Rita, Rose, Clair, Rosendale, Andrew, Rota-Stabelli, Omar, Savini, Grazia, Schoofs, Liliane, Scolari, Francesca, Swain, Martin, TakĂĄÄ, Peter, Tomlinson, Chad, Tsiamis, George, Abbeele, Jan, Vigneron, Aurelien, Jingwen Wang, Warren, Wesley, Waterhouse, Robert, Weirauch, Matthew, Weiss, Brian, Wilson, Richard, Zhao, Xin, and Aksoy, Serap
- Subjects
3. Good health - Abstract
Supplemental Figures S1-S12 and associated captions. (PDF 2260 kb)
21. Additional file 2: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
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Attardo, Geoffrey, Adly Abd-Alla, Acosta-Serrano, Alvaro, Allen, James, Bateta, Rosemary, Benoit, Joshua, Bourtzis, Kostas, Caers, Jelle, Caljon, Guy, Christensen, Mikkel, Farrow, David, Friedrich, Markus, AurĂŠlie Hua-Van, Jennings, Emily, Larkin, Denis, Lawson, Daniel, Lehane, Michael, Lenis, Vasileios, Lowy-Gallego, Ernesto, Macharia, Rosaline, Malacrida, Anna, Marco, Heather, Masiga, Daniel, Maslen, Gareth, Matetovici, Irina, Meisel, Richard, Meki, Irene, Michalkova, Veronika, Miller, Wolfgang, Minx, Patrick, Mireji, Paul, Ometto, Lino, Parker, Andrew, Rio, Rita, Rose, Clair, Rosendale, Andrew, Rota-Stabelli, Omar, Savini, Grazia, Schoofs, Liliane, Scolari, Francesca, Swain, Martin, TakĂĄÄ, Peter, Tomlinson, Chad, Tsiamis, George, Abbeele, Jan, Vigneron, Aurelien, Jingwen Wang, Warren, Wesley, Waterhouse, Robert, Weirauch, Matthew, Weiss, Brian, Wilson, Richard, Zhao, Xin, and Aksoy, Serap
- Subjects
3. Good health - Abstract
Supplemental Figures S1-S12 and associated captions. (PDF 2260 kb)
22. New genetic regulators question relevance of abundant yolk protein production in C. elegans.
- Author
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Rompay, Liesbeth Van, Borghgraef, Charline, Beets, Isabel, Caers, Jelle, and Temmerman, Liesbet
- Subjects
GENETIC regulation ,VITELLOGENESIS ,CAENORHABDITIS elegans ,EGG yolk ,REGULATOR genes - Abstract
Vitellogenesis or maternal yolk formation is considered critical to the reproduction of egg-laying animals. In invertebrates, however, most of its regulatory genes are still unknown. Via a combined mapping and whole-genome sequencing strategy, we performed a forward genetic screen to isolate novel regulators of yolk production in the nematode model system Caenorhabditis elegans. In addition to isolating new alleles of rab-35, rab-10 and M04F3.2, we identified five mutant alleles corresponding to three novel regulatory genes potently suppressing the expression of a GFP-based yolk reporter. We confirmed that mutations in vrp-1, ceh-60 and lrp-2 disrupt endogenous yolk protein synthesis at the transcriptional and translational level. In contrast to current beliefs, our discovered set of mutants with strongly reduced yolk proteins did not show serious reproduction defects. This raises questions as to whether yolk proteins per se are needed for ultimate reproductive success. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
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