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4. Contemporary Presentation and Management of Valvular Heart Disease The EURObservational Research Programme Valvular Heart Disease II Survey

Author

Iung, B., Delgado, V., Rosenhek, R., Price, S., Prendergast, B., Wendler, O., Bonis, M. de, Tribouilloy, C., Evangelista, A., Bogachev-Prokophiev, A., Apor, A., Ince, H., Laroche, C., Popescu, B.A., Pierard, L., Haude, M., Hindricks, G., Ruschitzka, F., Windecker, S., Bax, J.J., Maggioni, A., Vahanian, A., Mekhaldi, S., Lemaitre, K., Authier, S., Druais, H., Goda, A., Mascherbauer, J., Samadov, F., Pasquet, A., Linhartova, K., Ihlemann, N., Abdelhamid, M., Saraste, A., Kostovska, E.S., Bajraktari, G., Mirrakhimov, E., Erglis, A., Mizariene, V., Cassar, D., Tomkiewicz-Pajak, L., Ribeiras, R., Popescu, B., Beleslin, B., Simkova, I., Dogan, S.M., Rahman-Haley, S., Shirka, E., Dado, E., Zera, E., Bica, L., Heger, M., Muslumova, F., Jahangirov, T., Ahmedov, T., Husseynov, S., Cosyns, B., Camp, G. van, Sindelarova, S., Branny, M., Parenicova, I., Vondrackova, D.J., Homza, M., Ostransky, J., Hasan-Ali, H., Abdelhady, Y., Hassan, M., Soliman, H., Mostafa, A.E., Moaaz, M., Kazamel, G., Sadek, Y., Eltobgi, S., Kamal, D., Kylmala, M., Turpeinen, A., Monin, J.L., Jobic, Y., Attias, D., Magne, J., Marechaux, S., Donal, E., Biere, L., Bernard, A., Daudin, M., Khounlaboud, M., Habib, G., Bardet, H., Audonnet, M., Thuny, F., Plurien, F., Berenfeld, A., Gervais, R., Sorbets, E., Charbonnier, A., Bauer, F., Menager-Gangloff, C., Gjerakorska-Radovikj, M., Jordanova, S., Caglayan, E., Hambrecht, R., Akin, I., Maier, L., Nickenig, G., Scholtz, W., Schulze, P.C., Heintzen, M., Er, F., Sigusch, H., Spargias, K., Kamperidis, V., Sachpekidis, V., Bellos, V., Kanakakis, I., Papafaklis, M., Makris, A., Poulimenos, L., Katsaros, A., Lampropoulos, K., Bartha, E., Zsary, A., Jebelovszki, E., Cziraki, A., Borsanyi, T., Lupkovics, G., Jarai, Z., Ibrahimi, P., Arapova, R., Laahunova, E., Sime, I., Rancane, G., Radauskaite, G., Raugaliene, R., Xuereb, R.G., Djaberi, R., Komar, M., Szymanski, P., Zaborska, B., Mizia-Stec, K., Regulski, M., Bogacki, P., Sedziwy, E., Komor, K., Myszor, J., Joao, I., Martins, R., Cabral, S., Gago, P., Cardoso, G., Almeida, I., Antunes, N., Carvalho, S., Galrinho, A., Freitas, A., Grigorica, L., Mitre, A., Ionac, A., Tint, D., Popescu, A., Petris, A.O., Onut, R., Pop, C., Usurelu, C., Beyer, R., Militaru, C., Eminovici, G., Arsenescu-Georgescu, C., Irtyuga, O., Semenova, E., Boldyrev, S., Kozmin, D., Gross, Y., Zotov, A., Kuznetsov, D., Nemchenko, E., Kulumbegov, O., Jakubov, R., Stefanov, S., Schneider, Y., Tsechanovich, V., Gamzaev, A., Fomenko, M., Mayorova, O., Skripkina, E., Safina, V., Slastin, Y., Koroleva, T., Polyaeva, L., Tarasenko, I., Alekseeva, S., Magamet, V., Medvedev, I., Khilova, L., Verevetinov, A., Stojsic-Milosavljevic, A., Nikolic, N.M., Ostric, D.K., Ruzicic, D., Pavlovic, S., Milosavljevic, J., Jovovic, L., Margoczy, R., Valocik, G., Studencan, M., Iglesias, F.C., Mendez, I., Gomez, A.G., Sanchez Fernandez, P.L., Valenzuela, G.M., Cladellas, M., Villegas, D.V., Moral, S., Gallego, I.M., Paya, R., Caballero, L., Paton, R.R., Esteban, E., Iglesia-Carreno, C., Alberca, M.T., Valle, A., Molina-Mora, M.J., Castro, N., Sayar, N., Demirtas, A.O., Yesilay, A., Demir, S., Bozkurt, A., Kanar, B., Gudul, N.E., Yildirim, T., Taylan, G., Mert, K.U., Yilmaztepe, M.A., Mert, G.O., Cosansu, K., Sayin, M.R., Karabag, T., EORP VHD II Investigators, Instituto Universitario de Investigacion de Nanocienca de Aragon, University of Zaragoza - Universidad de Zaragoza [Zaragoza], Instituto de Física de Cantabria (IFCA), Universidad de Cantabria [Santander]-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Leibniz Institute for Astrophysics Potsdam (AIP), St. Josef Hospital, Ruhr-University Bochum, Université Paris Diderot - Paris 7 (UPD7), Institut National de la Santé et de la Recherche Médicale (INSERM), Leiden University Medical Center (LUMC), Universiteit Leiden, Medizinische Universität Wien = Medical University of Vienna, Department of Imaging Royal Brompton Hospital, Royal Brompton Hospital, Guy's and St Thomas' Hospital [London], CHU Amiens-Picardie, Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Vall d'Hebron University Hospital [Barcelona], Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire de Liège (CHU-Liège), Lukaskrankenhaus, Universität Leipzig, University Heart Centre Freiburg - Bad Krozingen, Research Center [Associazione Nazionale Medici Cardiologi Ospedalieri] (ANMCO Research Center), Associazione Nazionale Medici Cardiologi Ospedalieri [Firenze] (ANMCO), Service de cardiologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Uppsala University, SAFRAN Group, Laboratory of In Vivo Cellular and Molecular Imaging, Vrije Universiteit Brussel (VUB), Université de Lille, Sciences et Technologies, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes - Faculté de Médecine (UR Médecine), Université de Rennes (UR), CHU Pontchaillou [Rennes], Laboratoire de Protection et Remodelage du Myocarde (PMRM), Université d'Angers (UA)-Université d'Angers (UA), Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer (LabEx LipSTIC), Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Gustave Roussy (IGR)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Fédération Francophone de la Cancérologie Digestive, FFCD-Université de Montpellier (UM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), CHU de Saint-Brieuc, Hôpital Lapeyronie [Montpellier] (CHU), Assistance Publique - Hôpitaux de Marseille (APHM), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Institut de la Vision, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, University of Latvia (LU), Dipartimento di Scienza dei Materiali = Department of Materials Science [Milano-Bicocca], Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), MDM Laboratory, IMM-CNR, Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Réseaux épuration et qualité des eaux (UR REBX), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), King Abdullah University of Science and Technology (KAUST), INSTITUTO NACIONAL DE INVESTIGACAO AGRARIA E VETERINARIA VILA DO CONDE PRT, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Université de Médecine Carol Davila, Emergency Institute for Cardiovascular Diseases 'Prof. Dr. C.C. Iliescu' [Bucharest, Romania], Département Intelligence Ambiante et Systèmes Interactifs (DIASI), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Department of photonics engineering, Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Clinical sciences, Cardio-vascular diseases, Cardiology, Universität Leipzig [Leipzig], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes 1 - Faculté de Médecine (UR1 Médecine), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-École pratique des hautes études (EPHE), UNICANCER-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Fédération Francophone de la Cancérologie Digestive, FFCD-Université de Montpellier (UM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Technical University of Denmark [Lyngby] (DTU), Université d'Angers (UA), Iung, Bernard, Delgado, Victoria, Rosenhek, Raphael, Price, Susanna, Prendergast, Bernard, Wendler, Olaf, De Bonis, Michele, Tribouilloy, Christophe, Evangelista, Arturo, Bogachev-Prokophiev, Alexander, Apor, Astrid, Ince, Hüseyin, Laroche, Cécile, Popescu, Bogdan A, Piérard, Luc, Haude, Michael, Hindricks, Gerhard, Ruschitzka, Frank, Windecker, Stephan, Bax, Jeroen J, Maggioni, Aldo, and Vahanian, Alec

Subjects
Male, Time Factors, [SDV]Life Sciences [q-bio], 030204 cardiovascular system & hematology, heart valve diseases, valvular surgery, Cardiologists, 0302 clinical medicine, Time-to-Treatment/trends, Referral and Consultation/trends, Heart Valve Diseases/diagnosis, Medicine, echocardiography, 03.02. Klinikai orvostan, 030212 general & internal medicine, Prospective Studies, Practice Patterns, Physicians', 610 Medicine & health, Referral and Consultation, valvular heart disease, Middle Aged, Europe, Practice Guidelines as Topic, cardiovascular system, Healthcare Disparities/trends, transcatheter aortic valve replacement, Female, Guideline Adherence, Presentation (obstetrics), Cardiology and Cardiovascular Medicine, guideline, Cardiologists/trends, medicine.medical_specialty, transcatheter intervention, Clinical Decision-Making, Time-to-Treatment, Europe/epidemiology, 03 medical and health sciences, Physiology (medical), Guideline Adherence/trends, Humans, Healthcare Disparities, Intensive care medicine, Aged, business.industry, medicine.disease, Practice Patterns, Physicians'/trends, Health Care Surveys, business, aged, 80 and over, guidelines as topic
Abstract

Background: Valvular heart disease (VHD) is an important cause of mortality and morbidity and has been subject to important changes in management. The VHD II survey was designed by the EURObservational Research Programme of the European Society of Cardiology to analyze actual management of VHD and to compare practice with guidelines. Methods: Patients with severe native VHD or previous valvular intervention were enrolled prospectively across 28 countries over a 3-month period in 2017. Indications for intervention were considered concordant if the intervention was performed or scheduled in symptomatic patients, corresponding to Class I recommendations specified in the 2012 European Society of Cardiology and in the 2014 American Heart Association/American College of Cardiology VHD guidelines. Results: A total of 7247 patients (4483 hospitalized, 2764 outpatients) were included in 222 centers. Median age was 71 years (interquartile range, 62–80 years); 1917 patients (26.5%) were ≥80 years; and 3416 were female (47.1%). Severe native VHD was present in 5219 patients (72.0%): aortic stenosis in 2152 (41.2% of native VHD), aortic regurgitation in 279 (5.3%), mitral stenosis in 234 (4.5%), mitral regurgitation in 1114 (21.3%; primary in 746 and secondary in 368), multiple left-sided VHD in 1297 (24.9%), and right-sided VHD in 143 (2.7%). Two thousand twenty-eight patients (28.0%) had undergone previous valvular intervention. Intervention was performed in 37.0% and scheduled in 26.8% of patients with native VHD. The decision for intervention was concordant with Class I recommendations in symptomatic patients with severe single left-sided native VHD in 79.4% (95% CI, 77.1–81.6) for aortic stenosis, 77.6% (95% CI, 69.9–84.0) for aortic regurgitation, 68.5% (95% CI, 60.8–75.4) for mitral stenosis, and 71.0% (95% CI, 66.4–75.3) for primary mitral regurgitation. Valvular interventions were performed in 2150 patients during the survey; of them, 47.8% of patients with single left-sided native VHD were in New York Heart Association class III or IV. Transcatheter procedures were performed in 38.7% of patients with aortic stenosis and 16.7% of those with mitral regurgitation. Conclusions: Despite good concordance between Class I recommendations and practice in patients with aortic VHD, the suboptimal number in mitral VHD and late referral for valvular interventions suggest the need to improve further guideline implementation.

Published
2019

5. EVALUATION OF GERIATRIC PATIENTS PRESENTING TO EMERGENCY DEPARTMENT WITH TRAUMA

Author

Caglayan, S., Celik, B., Caglayan, E., Celik, N., Ozturk, D., Altinbilek, E., and Kavalci, C.

Subjects
гериатрия, trauma, отделение неотложной помощи, emergency department, falling, geriatric, травма, падение, құлау, жедел көмек бөлімі, жарақат
Abstract

Objective: Elderly people are more open to accidents due to the physical changes brought by ageing, and an accident or falling that may not cause an important problem in a normal healthy adult may lead to significant injury even death in elderly persons. In this study, we aimed to prospectively determine demographic features, clinical findings, comorbidities, trauma mechanisms and trauma localizations in geriatric patients who presented to our hospital, and to provide contribution to the management of geriatric trauma patients that account for a considerable part of presentations to emergency departments. Method: This study included a total of 2108 geriatric patients aged 65 years and over, who presented to the emergency department of Sisli Hamidiye Etfal Training & Research Hospital due to trauma between 01/12/2014 and 30/11/2015. Patients’ demographic data, the way of arrival to emergency department, body region of trauma, GCS scores at the time of admission, vital findings at the time of admission and scene of the trauma were recorded. All data obtained about the patients were recorded to the prepared forms. Results: The incidence of geriatric trauma cases was 0.62% among all presentations. The rate of traumas experienced at street by patients aged under 75 years was significantly higher than those experienced at street by patients aged over 75 years (p, Мақсаты: Егде жастағы адамдар қартаюдан туындаған физикалық қиындықтар арқасында жазатайым жағдайларға бейім. Ересек адамда қиындықтар туғызбауы мүмкін апат немесе құлдырау түрлері егде жастағы адамдарда ауыр жарақаттарға әкеп соғып, тіпті өлімге әкелуі де мүмкін. Бұл зерттеуде біз жедел бөлімде емделетін гериатриялық науқастарда демографиялық белгілерді, клиникалық көріністерді, сырқаттанушылықтарды, жарақаттық механизмдерді және жарақаттардың орналасуын перспективті түрде бағалауға тырыстық, сондай-ақ, гериатрлы жарақат алған науқастарды басқарудың тактикасын анықтадық. Құралдар мен әдістер. Бұл зерттеуге жастары 65 және одан жоғары жастағы 2108 науқас қатысты, олар Этфаледегі Шишли Хамидие оқыту және зерттеу ауруханасының жедел жәрдем бөліміне 2014 жылдың 1 қаңтарынан бастап 30 қарашаға дейінгі кезеңде жарақатқа байланысты қаралған. Науқастардың демографиялық деректері, төтенше жағдайлар бөліміне жеткізу әдісі, жарақаттың орналасуы, қабылдау кезінде GCS баллдары, қабылдау кезінде өмірлік белгілер және жарақаттар орыны талданды. Барлық науқастар туралы алынған деректер арнайы әзірленген нысандарға енгізілді. Нәтижелер: Барлық науқастарда гериатриялық зақымдану деңгейі 0,62% құрады. 75 жастағы науқастарда көшеде алған жарақаттардың жиілігі 75 жастан асқан науқастармен салыстырғанда статистикалық жағынан айтарлықтай жоғары болды (р, Наука и здравоохранение, Выпуск 3 (21) 2019

Published
2019
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8. Poster Session Saturday 14 December - AM: 14/12/2013 08:30-12:30 * Location: Poster area

Author

Muraru, D., Addetia, K., Veronesi, F., Corsi, C., Mor-Avi, V., Yamat, M., Weinert, L., Lang, R., Badano, L., Faita, F., Di Lascio, N., Bruno, R., Bianchini, E., Ghiadoni, L., Sicari, R., Gemignani, V., Angelis, A., Ageli, K., Ioakimidis, N., Chrysohoou, C., Agelakas, A., Felekos, I., Vaina, S., Aznaourides, K., Vlachopoulos, C., Stefanadis, C., Nemes, A., Szolnoky, G., Gavaller, H., Gonczy, A., Kemeny, L., Forster, T., Ramalho, A., Placido, R., Marta, L., Menezes, M., Magalhaes, A., Cortez Dias, N., Martins, S., Almeida, A., Pinto, F., Nunes Diogo, A., Botezatu, C.-D., Enache, R., Popescu, B., Nastase, O., Coman, M., Ghiorghiu, I., Calin, A., Rosca, M., Beladan, C., Ginghina, C., Grapsa, J., Cabrita, I., Durighel, G., O'regan, D., Dawson, D., Nihoyannopoulos, P., Pellicori, P., Kallvikbacka-Bennett, A., Zhang, J., Lukaschuk, E., Joseph, A., Bourantas, C., Loh, H., Bragadeesh, T., Clark, A., Cleland, J., Lomax, S., Putzu, P., Diercx, R., Parsons, S., Dicken, B., Vered, Z., Adirevitz, L., Dragu, R., Blatt, A., Karev, E., Malca, Y., Roytvarf, A., Marek, D., Sovova, E., Berkova, M., Cihalik, C., Taborsky, M., Lindqvist, P., Tossavainen, E., Soderberg, S., Gonzales, M., Gustavsson, S., Henein, M., Sonne, C., Bott-Fluegel, L., Hauck, S., Lesevic, H., Hadamitzky, M., Wolf, P., Kolb, C., Bandera, F., Pellegrino, M., Generati, G., Donghi, V., Alfonzetti, E., Castelvecchio, S., Menicanti, L., Guazzi, M., Buchyte, S., Rinkuniene, D., Jurkevicius, R., Smarz, K., Zaborska, B., Jaxa-Chamiec, T., Maciejewski, P., Budaj, A., Santoro, A., Federico Alvino, F., Giovanni Antonelli, G., Roberta Molle, R., Matteo Bertini, M., Stefano Lunghetti, S., Sergio Mondillo, S., Henri, C., Magne, J., Dulgheru, R., Laaraibi, S., Voilliot, D., Kou, S., Pierard, L., Lancellotti, P., Szulik, M., Stabryla-Deska, J., Kalinowski, M., Sliwinska, A., Szymala, M., Lenarczyk, R., Kalarus, Z., Kukulski, T., Yiangou, K., Azina, C., Yiangou, A., Ioannides, M., Chimonides, S., Baysal, S., Pirat, B., Okyay, K., Bal, U., Muderrisoglu, H., Popovic, D., Ostojic, M., Petrovic, M., Vujisic-Tesic, B., Arandjelovic, A., Petrovic, I., Banovic, M., Popovic, B., Vukcevic, V., Damjanovic, S., Velasco Del Castillo, S., Onaindia Gandarias, J., Arana Achaga, X., Laraudogoitia Zaldumbide, E., Rodriguez Sanchez, I., Cacicedo De Bobadilla, A., Romero Pereiro, A., Aguirre Larracoechea, U., Salinas, T., Subinas, A., Elzbieciak, M., Wita, K., Grabka, M., Chmurawa, J., Doruchowska, A., Turski, M., Filipecki, A., Wybraniec, M., Mizia-Stec, K., Varho, V., Karjalainen, P., Lehtinen, T., Airaksinen, J., Ylitalo, A., Kiviniemi, T., Gargiulo, P., Galderisi, M., D' Amore, C., Lo Iudice, F., Savarese, G., Casaretti, L., Pellegrino, A., Fabiani, I., La Mura, L., Perrone Filardi, P., Kim, J. Y., Chung, W., Yu, J., Choi, Y., Park, C., Youn, H., Lee, M., Nagy, A., Manouras, A., Gunyeli, E., Gustafsson, U., Shahgaldi, K., Winter, R., Johnsson, J., Zagatina, A., Krylova, L., Zhuravskaya, N., Vareldzyan, Y., Tyurina, T., Clitsenko, O., Khalifa, E. A., Ashour, Z., Elnagar, W., Jung, I., Seo, H., Lee, S., Lim, D., Mizariene, V., Verseckaite, R., Janenaite, J., Jonkaitiene, R., Sanchez Espino, A., Bonaque Gonzalez, J., Merchan Ortega, G., Bolivar Herrera, N., Ikuta, I., Macancela Quinones, J., Gomez Recio, M., Silva Fazendas Adame, P. R., Caldeira, D., Stuart, B., Almeida, S., Cruz, I., Ferreira, A., Freire, G., Lopes, L., Cotrim, C., Pereira, H., Mediratta, A., Moss, J., Nayak, H., Al Amri, I., Debonnaire, P., Van Der Kley, F., Schalij, M., Bax, J., Ajmone Marsan, N., Delgado, V., Schmidt, F. P., Gniewosz, T., Jabs, A., Munzel, T., Jansen, T., Kaempfner, D., Hink, U., Von Bardeleben, R., Jose, J., George, O., Joseph, G., Adawi, S., Najjar, R., Ahronson, D., Shiran, A., Van Riel, A., Boerlage - Van Dijk, K., De Bruin - Bon, H., Araki, M., Meregalli, P., Koch, K., Vis, M., Mulder, B., Baan, J., Bouma, B., Marciniak, A., Elton, D., Glover, K., Campbell, I., Sharma, R., Batalha, S., Lourenco, C., Oliveira Da Silva, C., Caballero, L., Garcia-Lara, J., Gonzalez-Carrillo, J., Oliva, M., Saura, D., Garcia-Navarro, M., Espinosa, M., Pinar, E., Valdes, M., De La Morena, G., Barreiro Perez, M., Lopez Perez, M., Roy, D., Brecker, S., Venkateshvaran, A., Dash, P. K., Sola, S., Barooah, B., Govind, S. C., Brodin, L. A., Saura Espin, D., Caballero Jimenez, L., Gonzalez Carrillo, J., Oliva Sandoval, M., Lopez Ruiz, M., Garcia Navarro, M., Espinosa Garcia, M., Valdes Chavarri, M., De La Morena Valenzuela, G., Gatti, G., Dell'angela, L., Pinamonti, B., Benussi, B., Sinagra, G., Pappalardo, A., Hernandez, V., Saavedra, J., Gonzalez, A., Iglesias, P., Civantos, S., Guijarro, G., Monereo, S., Ikeda, M., Toh, N., Oe, H., Tanabe, Y., Watanabe, N., Ito, H., Ciampi, Q., Cortigiani, L., Pratali, L., Rigo, F., Villari, B., Picano, E., Yoon, J., Sohn, J., Kim, Y., Chang, H., Hong, G., Kim, T., Ha, J., Choi, B., Rim, S., Choi, E., Tibazarwa, K., Sliwa, K., Wonkam, A., Mayosi, B., Oryshchyn, N., Ivaniv, Y., Pavlyk, S., Lourenco, M. R., Azevedo, O., Moutinho, J., Nogueira, I., Fernandes, M., Pereira, V., Quelhas, I., Lourenco, A., Sunbul, M., Tigen, K., Karaahmet, T., Dundar, C., Ozben, B., Guler, A., Cincin, A., Bulut, M., Sari, I., Basaran, Y., Baydar, O., Kadriye Kilickesmez, K., Ugur Coskun, U., Polat Canbolat, P., Veysel Oktay, V., Umit Yasar Sinan, U., Okay Abaci, O., Cuneyt Kocas, C., Sinan Uner, S., Serdar Kucukoglu, S., Zaroui, A., Mourali, M., Ben Said, R., Asmi, M., Aloui, H., Kaabachi, N., Mechmeche, R., Saberniak, J., Hasselberg, N., Borgquist, R., Platonov, P., Holst, A., Edvardsen, T., Haugaa, K., Eran, A., Yueksel, D., Er, F., Gassanov, N., Rosenkranz, S., Baldus, S., Guedelhoefer, H., Faust, M., Caglayan, E., Matveeva, N., Nartsissova, G., Chernjavskij, A., Ippolito, R., De Palma, D., Muscariello, R., Santoro, C., Raia, R., Schiano-Lomoriello, V., Gargiulo, F., Lipari, P., Bonapace, S., Zenari, L., Valbusa, F., Rossi, A., Lanzoni, L., Canali, G., Molon, G., Campopiano, E., Barbieri, E., Ikonomidis, I., Varoudi, M., Papadavid, E., Theodoropoulos, K., Papadakis, I., Pavlidis, G., Triantafyllidi, H., Anastasiou - Nana, M., Rigopoulos, D., Lekakis, J., Ozen, G., Durmus, E., Kivrak, T., Atas, H., Direskeneli, H., Stevanovic, A., Dekleva, M., Trajic, S., Paunovic, N., Simic, A., Khan, S., Mushemi-Blake, S., Jouhra, F., Dennes, W., Monaghan, M., Melikian, N., Shah, A., Maceira Gonzalez, A. M., Lopez-Lereu, M., Monmeneu, J., Igual, B., Estornell, J., Boraita, A., Kosmala, W., Rojek, A., Bialy, D., Mysiak, A., Przewlocka-Kosmala, M., Popescu, I., Mancas, S., Mornos, C., Serbescu, I., Ionescu, G., Ionac, A., Gaudron, P., Niemann, M., Herrmann, S., Hu, K., Liu, D., Wojciech, K., Frantz, S., Bijnens, B., Ertl, G., Weidemann, F., Cosin-Sales, J., Ruvira, J., Diago, J., Aguilar, J., Cruz, C., Pinho, T., Madureira, A., Lebreiro, A., Dias, C., Ramos, I., Silva Cardoso, J., Julia Maciel, M., De Meester, P., Van De Bruaene, A., Herijgers, P., Voigt, J.-U., Budts, W., Franzoso, F., Voser, E., Wohlmut, C., Kellenberger, C., Valsangiacomo Buechel, E., Carrero, C., Benger, J., Parcerisa, M., Falconi, M., Oberti, P., Granja, M., Cagide, A., Del Pasqua, A., Secinaro, A., Antonelli, G., Iacomino, M., Toscano, A., Chinali, M., Esposito, C., Carotti, A., Pongiglione, G., Rinelli, G., Youssef Moustafa, A., Al Murayeh, M., Al Masswary, A., Al Sheikh, K., Moselhy, M., Dardir, M., Deising, J., Butz, T., Suermeci, G., Liebeton, J., Wennemann, R., Tzikas, S., Van Bracht, M., Prull, M., Trappe, H.-J., Martin Hidalgo, M., Delgado Ortega, M., Ruiz Ortiz, M., Mesa Rubio, D., Carrasco Avalos, F., Seoane Garcia, T., Pan Alvarez-Ossorio, M., Lopez Aguilera, J., Puentes Chiachio, M., Suarez De Lezo Cruz Conde, J., Petrovic, M. T., Giga, V., Stepanovic, J., Tesic, M., Jovanovic, I., Djordjevic-Dikic, A., Piatkowski, R., Kochanowski, J., Scislo, P., Opolski, G., Vareldzhyan, Y., Bombardini, T., Gherardi, S., Leone, O., Michelotto, E., Ciccarone, A., Tarantino, N., Ostuni, V., Rubino, M., Genco, W., Santoro, G., Carretta, D., Romito, R., Colonna, P., Cameli, M., Lunghetti, S., Lisi, M., Curci, V., Cameli, P., Focardi, M., Favilli, R., Mondillo, S., Hoffmann, R., Barletta, G., Von Bardeleben, S., Kasprzak, J., Greis, C., Vanoverschelde, J., Becher, H., Machida, T., Izumo, M., Suzuki, K., Kaimijima, R., Mizukoshi, K., Manabe-Uematsu, M., Takai, M., Harada, T., Akashi, Y., Martin Garcia, A., Arribas-Jimenez, A., Cruz-Gonzalez, I., Nieto, F., Iscar, A., Merchan, S., Martin-Luengo, C., Brecht, A., Theres, L., Spethmann, S., Dreger, H., Baumann, G., Knebel, F., Jasaityte, R., Heyde, B., Rademakers, F., Claus, P., D'hooge, J., Lervik Nilsen, L. C., Lund, J., Brekke, B., Stoylen, A., Giraldeau, G., Duchateau, N., Gabrielli, L., Penela, D., Evertz, R., Mont, L., Brugada, J., Berruezo, A., Sitges, M., Kordybach, M., Kowalski, M., Hoffman, P., Pilichowska, E., Baran, J., Kulakowski, P., Wahi, S., Vollbon, W., Leano, R., Thomas, A., Bricknell, K., Holland, D., Napier, S., Stanton, T., Teferici, D., Qirko, S., Petrela, E., Dibra, A., Bajraktari, G., Bara, P., Sanchis Ruiz, L., Andrea, R., Falces, C., Perez-Villa, F., Sulemane, S., Panoulas, V., Bratsas, A., Tam, F., Abduch, M., Alencar, A., Coracin, F., Barban, A., Saboya, R., Dulley, F., Mathias, W., Vieira, M., Buccheri, S., Mangiafico, S., Arcidiacono, A., Bottari, V., Leggio, S., Tamburino, C., Monte, I. P., Spitzer, E., Beitzke, D., Kaneider, A., Pavo, N., Gottsauner-Wolf, M., Wolf, F., Loewe, C., Mushtaq, S., Andreini, D., Pontone, G., Bertella, E., Conte, E., Baggiano, A., Annoni, A., Cortinovis, S., Fiorentini, C., Pepi, M., Gustafsson, M., Alehagen, U., Dahlstrom, U., Johansson, P., Faden, G., Faggiano, P., Albertini, L., Reverberi, C., Gaibazzi, N., Taylor, R. J., Moody, W., Umar, F., Edwards, N., Townend, J., Steeds, R., Leyva, F., Mihaila, S., Piasentini, E., Peluso, D., Casablanca, S., Naso, P., Puma, L., Iliceto, S., Vinereanu, D., Ciciarello, F. L., Agati, L., Cimino, S., De Luca, L., Petronilli, V., Fedele, F., and Tsverava, M.

Subjects
medicine.medical_specialty, Bundle branch block, business.industry, Left bundle branch block, Speckle tracking echocardiography, General Medicine, 030204 cardiovascular system & hematology, medicine.disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Radial function, Ventricle, Internal medicine, Cardiology, medicine, Radiology, Nuclear Medicine and imaging, In patient, Cardiology and Cardiovascular Medicine, business
Published
2013
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9. Left atrial function measured by cardiac magnetic resonance in patients with heart failure: clinical associations and prognostic value

Author

Muraru, D., Addetia, K., Veronesi, F., Corsi, C., Mor-Avi, V., Yamat, M., Weinert, L., Lang, R., Badano, L., Faita, F., Di Lascio, N., Bruno, R., Bianchini, E., Ghiadoni, L., Sicari, R., Gemignani, V., Angelis, A., Ageli, K., Ioakimidis, N., Chrysohoou, C., Agelakas, A., Felekos, I., Vaina, S., Aznaourides, K., Vlachopoulos, C., Stefanadis, C., Nemes, A., Szolnoky, G., Gavaller, H., Gonczy, A., Kemeny, L., Forster, T., Ramalho, A., Placido, R., Marta, L., Menezes, M., Magalhaes, A., Cortez Dias, N., Martins, S., Almeida, A., Pinto, F., Nunes Diogo, A., Botezatu, C.-D., Enache, R., Popescu, B., Nastase, O., Coman, M., Ghiorghiu, I., Calin, A., Rosca, M., Beladan, C., Ginghina, C., Grapsa, J., Cabrita, I., Durighel, G., O'regan, D., Dawson, D., Nihoyannopoulos, P., Pellicori, P., Kallvikbacka-Bennett, A., Zhang, J., Lukaschuk, E., Joseph, A., Bourantas, C., Loh, H., Bragadeesh, T., Clark, A., Cleland, J., Lomax, S., Putzu, P., Diercx, R., Parsons, S., Dicken, B., Vered, Z., Adirevitz, L., Dragu, R., Blatt, A., Karev, E., Malca, Y., Roytvarf, A., Marek, D., Sovova, E., Berkova, M., Cihalik, C., Taborsky, M., Lindqvist, P., Tossavainen, E., Soderberg, S., Gonzales, M., Gustavsson, S., Henein, M., Sonne, C., Bott-Fluegel, L., Hauck, S., Lesevic, H., Hadamitzky, M., Wolf, P., Kolb, C., Bandera, F., Pellegrino, M., Generati, G., Donghi, V., Alfonzetti, E., Castelvecchio, S., Menicanti, L., Guazzi, M., Buchyte, S., Rinkuniene, D., Jurkevicius, R., Smarz, K., Zaborska, B., Jaxa-Chamiec, T., Maciejewski, P., Budaj, A., Santoro, A., Federico Alvino, F., Giovanni Antonelli, G., Roberta Molle, R., Matteo Bertini, M., Stefano Lunghetti, S., Sergio Mondillo, S., Henri, C., Magne, J., Dulgheru, R., Laaraibi, S., Voilliot, D., Kou, S., Pierard, L., Lancellotti, P., Szulik, M., Stabryla-Deska, J., Kalinowski, M., Sliwinska, A., Szymala, M., Lenarczyk, R., Kalarus, Z., Kukulski, T., Yiangou, K., Azina, C., Yiangou, A., Ioannides, M., Chimonides, S., Baysal, S., Pirat, B., Okyay, K., Bal, U., Muderrisoglu, H., Popovic, D., Ostojic, M., Petrovic, M., Vujisic-Tesic, B., Arandjelovic, A., Petrovic, I., Banovic, M., Popovic, B., Vukcevic, V., Damjanovic, S., Velasco Del Castillo, S., Onaindia Gandarias, J., Arana Achaga, X., Laraudogoitia Zaldumbide, E., Rodriguez Sanchez, I., Cacicedo De Bobadilla, A., Romero Pereiro, A., Aguirre Larracoechea, U., Salinas, T., Subinas, A., Elzbieciak, M., Wita, K., Grabka, M., Chmurawa, J., Doruchowska, A., Turski, M., Filipecki, A., Wybraniec, M., Mizia-Stec, K., Varho, V., Karjalainen, P., Lehtinen, T., Airaksinen, J., Ylitalo, A., Kiviniemi, T., Gargiulo, P., Galderisi, M., D' Amore, C., Lo Iudice, F., Savarese, G., Casaretti, L., Pellegrino, A., Fabiani, I., La Mura, L., Perrone Filardi, P., Kim, J. Y., Chung, W., Yu, J., Choi, Y., Park, C., Youn, H., Lee, M., Nagy, A., Manouras, A., Gunyeli, E., Gustafsson, U., Shahgaldi, K., Winter, R., Johnsson, J., Zagatina, A., Krylova, L., Zhuravskaya, N., Vareldzyan, Y., Tyurina, T., Clitsenko, O., Khalifa, E. A., Ashour, Z., Elnagar, W., Jung, I., Seo, H., Lee, S., Lim, D., Mizariene, V., Verseckaite, R., Janenaite, J., Jonkaitiene, R., Sanchez Espino, A., Bonaque Gonzalez, J., Merchan Ortega, G., Bolivar Herrera, N., Ikuta, I., Macancela Quinones, J., Gomez Recio, M., Silva Fazendas Adame, P. R., Caldeira, D., Stuart, B., Almeida, S., Cruz, I., Ferreira, A., Freire, G., Lopes, L., Cotrim, C., Pereira, H., Mediratta, A., Moss, J., Nayak, H., Al Amri, I., Debonnaire, P., Van Der Kley, F., Schalij, M., Bax, J., Ajmone Marsan, N., Delgado, V., Schmidt, F. P., Gniewosz, T., Jabs, A., Munzel, T., Jansen, T., Kaempfner, D., Hink, U., Von Bardeleben, R., Jose, J., George, O., Joseph, G., Adawi, S., Najjar, R., Ahronson, D., Shiran, A., Van Riel, A., Boerlage - Van Dijk, K., De Bruin - Bon, H., Araki, M., Meregalli, P., Koch, K., Vis, M., Mulder, B., Baan, J., Bouma, B., Marciniak, A., Elton, D., Glover, K., Campbell, I., Sharma, R., Batalha, S., Lourenco, C., Oliveira Da Silva, C., Caballero, L., Garcia-Lara, J., Gonzalez-Carrillo, J., Oliva, M., Saura, D., Garcia-Navarro, M., Espinosa, M., Pinar, E., Valdes, M., De La Morena, G., Barreiro Perez, M., Lopez Perez, M., Roy, D., Brecker, S., Venkateshvaran, A., Dash, P. K., Sola, S., Barooah, B., Govind, S. C., Brodin, L. A., Saura Espin, D., Caballero Jimenez, L., Gonzalez Carrillo, J., Oliva Sandoval, M., Lopez Ruiz, M., Garcia Navarro, M., Espinosa Garcia, M., Valdes Chavarri, M., De La Morena Valenzuela, G., Gatti, G., Dell'angela, L., Pinamonti, B., Benussi, B., Sinagra, G., Pappalardo, A., Hernandez, V., Saavedra, J., Gonzalez, A., Iglesias, P., Civantos, S., Guijarro, G., Monereo, S., Ikeda, M., Toh, N., Oe, H., Tanabe, Y., Watanabe, N., Ito, H., Ciampi, Q., Cortigiani, L., Pratali, L., Rigo, F., Villari, B., Picano, E., Yoon, J., Sohn, J., Kim, Y., Chang, H., Hong, G., Kim, T., Ha, J., Choi, B., Rim, S., Choi, E., Tibazarwa, K., Sliwa, K., Wonkam, A., Mayosi, B., Oryshchyn, N., Ivaniv, Y., Pavlyk, S., Lourenco, M. R., Azevedo, O., Moutinho, J., Nogueira, I., Fernandes, M., Pereira, V., Quelhas, I., Lourenco, A., Sunbul, M., Tigen, K., Karaahmet, T., Dundar, C., Ozben, B., Guler, A., Cincin, A., Bulut, M., Sari, I., Basaran, Y., Baydar, O., Kadriye Kilickesmez, K., Ugur Coskun, U., Polat Canbolat, P., Veysel Oktay, V., Umit Yasar Sinan, U., Okay Abaci, O., Cuneyt Kocas, C., Sinan Uner, S., Serdar Kucukoglu, S., Zaroui, A., Mourali, M., Ben Said, R., Asmi, M., Aloui, H., Kaabachi, N., Mechmeche, R., Saberniak, J., Hasselberg, N., Borgquist, R., Platonov, P., Holst, A., Edvardsen, T., Haugaa, K., Eran, A., Yueksel, D., Er, F., Gassanov, N., Rosenkranz, S., Baldus, S., Guedelhoefer, H., Faust, M., Caglayan, E., Matveeva, N., Nartsissova, G., Chernjavskij, A., Ippolito, R., De Palma, D., Muscariello, R., Santoro, C., Raia, R., Schiano-Lomoriello, V., Gargiulo, F., Lipari, P., Bonapace, S., Zenari, L., Valbusa, F., Rossi, A., Lanzoni, L., Canali, G., Molon, G., Campopiano, E., Barbieri, E., Ikonomidis, I., Varoudi, M., Papadavid, E., Theodoropoulos, K., Papadakis, I., Pavlidis, G., Triantafyllidi, H., Anastasiou - Nana, M., Rigopoulos, D., Lekakis, J., Ozen, G., Durmus, E., Kivrak, T., Atas, H., Direskeneli, H., Stevanovic, A., Dekleva, M., Trajic, S., Paunovic, N., Simic, A., Khan, S., Mushemi-Blake, S., Jouhra, F., Dennes, W., Monaghan, M., Melikian, N., Shah, A., Maceira Gonzalez, A. M., Lopez-Lereu, M., Monmeneu, J., Igual, B., Estornell, J., Boraita, A., Kosmala, W., Rojek, A., Bialy, D., Mysiak, A., Przewlocka-Kosmala, M., Popescu, I., Mancas, S., Mornos, C., Serbescu, I., Ionescu, G., Ionac, A., Gaudron, P., Niemann, M., Herrmann, S., Hu, K., Liu, D., Wojciech, K., Frantz, S., Bijnens, B., Ertl, G., Weidemann, F., Cosin-Sales, J., Ruvira, J., Diago, J., Aguilar, J., Cruz, C., Pinho, T., Madureira, A., Lebreiro, A., Dias, C., Ramos, I., Silva Cardoso, J., Julia Maciel, M., De Meester, P., Van De Bruaene, A., Herijgers, P., Voigt, J.-U., Budts, W., Franzoso, F., Voser, E., Wohlmut, C., Kellenberger, C., Valsangiacomo Buechel, E., Carrero, C., Benger, J., Parcerisa, M., Falconi, M., Oberti, P., Granja, M., Cagide, A., Del Pasqua, A., Secinaro, A., Antonelli, G., Iacomino, M., Toscano, A., Chinali, M., Esposito, C., Carotti, A., Pongiglione, G., Rinelli, G., Youssef Moustafa, A., Al Murayeh, M., Al Masswary, A., Al Sheikh, K., Moselhy, M., Dardir, M., Deising, J., Butz, T., Suermeci, G., Liebeton, J., Wennemann, R., Tzikas, S., Van Bracht, M., Prull, M., Trappe, H.-J., Martin Hidalgo, M., Delgado Ortega, M., Ruiz Ortiz, M., Mesa Rubio, D., Carrasco Avalos, F., Seoane Garcia, T., Pan Alvarez-Ossorio, M., Lopez Aguilera, J., Puentes Chiachio, M., Suarez De Lezo Cruz Conde, J., Petrovic, M. T., Giga, V., Stepanovic, J., Tesic, M., Jovanovic, I., Djordjevic-Dikic, A., Piatkowski, R., Kochanowski, J., Scislo, P., Opolski, G., Vareldzhyan, Y., Bombardini, T., Gherardi, S., Leone, O., Michelotto, E., Ciccarone, A., Tarantino, N., Ostuni, V., Rubino, M., Genco, W., Santoro, G., Carretta, D., Romito, R., Colonna, P., Cameli, M., Lunghetti, S., Lisi, M., Curci, V., Cameli, P., Focardi, M., Favilli, R., Mondillo, S., Hoffmann, R., Barletta, G., Von Bardeleben, S., Kasprzak, J., Greis, C., Vanoverschelde, J., Becher, H., Machida, T., Izumo, M., Suzuki, K., Kaimijima, R., Mizukoshi, K., Manabe-Uematsu, M., Takai, M., Harada, T., Akashi, Y., Martin Garcia, A., Arribas-Jimenez, A., Cruz-Gonzalez, I., Nieto, F., Iscar, A., Merchan, S., Martin-Luengo, C., Brecht, A., Theres, L., Spethmann, S., Dreger, H., Baumann, G., Knebel, F., Jasaityte, R., Heyde, B., Rademakers, F., Claus, P., D'hooge, J., Lervik Nilsen, L. C., Lund, J., Brekke, B., Stoylen, A., Giraldeau, G., Duchateau, N., Gabrielli, L., Penela, D., Evertz, R., Mont, L., Brugada, J., Berruezo, A., Sitges, M., Kordybach, M., Kowalski, M., Hoffman, P., Pilichowska, E., Baran, J., Kulakowski, P., Wahi, S., Vollbon, W., Leano, R., Thomas, A., Bricknell, K., Holland, D., Napier, S., Stanton, T., Teferici, D., Qirko, S., Petrela, E., Dibra, A., Bajraktari, G., Bara, P., Sanchis Ruiz, L., Andrea, R., Falces, C., Perez-Villa, F., Sulemane, S., Panoulas, V., Bratsas, A., Tam, F., Abduch, M., Alencar, A., Coracin, F., Barban, A., Saboya, R., Dulley, F., Mathias, W., Vieira, M., Buccheri, S., Mangiafico, S., Arcidiacono, A., Bottari, V., Leggio, S., Tamburino, C., Monte, I. P., Spitzer, E., Beitzke, D., Kaneider, A., Pavo, N., Gottsauner-Wolf, M., Wolf, F., Loewe, C., Mushtaq, S., Andreini, D., Pontone, G., Bertella, E., Conte, E., Baggiano, A., Annoni, A., Cortinovis, S., Fiorentini, C., Pepi, M., Gustafsson, M., Alehagen, U., Dahlstrom, U., Johansson, P., Faden, G., Faggiano, P., Albertini, L., Reverberi, C., Gaibazzi, N., Taylor, R. J., Moody, W., Umar, F., Edwards, N., Townend, J., Steeds, R., Leyva, F., Mihaila, S., Piasentini, E., Peluso, D., Casablanca, S., Naso, P., Puma, L., Iliceto, S., Vinereanu, D., Ciciarello, F. L., Agati, L., Cimino, S., De Luca, L., Petronilli, V., Fedele, F., and Tsverava, M.

Published
2013
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12. Influence of dietary state and insulin on myocardial, skeletal muscle and brain [F]-fluorodeoxyglucose kinetics in mice

Author

Kreissl, M.C., Stout, D.B., Wong, K.P., Wu, H.M., Caglayan, E., Ladno, W., Zhang, X., Prior, J.O., Reiners, C., Huang, S.C., and Schelbert, H.R.

Subjects
Original Research
Abstract

Background We evaluated the effect of insulin stimulation and dietary changes on myocardial, skeletal muscle and brain [18F]-fluorodeoxyglucose (FDG) kinetics and uptake in vivo in intact mice. Methods Mice were anesthetized with isoflurane and imaged under different conditions: non-fasted (n = 7; "controls"), non-fasted with insulin (2 IU/kg body weight) injected subcutaneously immediately prior to FDG (n = 6), fasted (n = 5), and fasted with insulin injection (n = 5). A 60-min small-animal PET with serial blood sampling and kinetic modeling was performed. Results We found comparable FDG standardized uptake values (SUVs) in myocardium in the non-fasted controls and non-fasted-insulin injected group (SUV 45-60 min, 9.58 ± 1.62 vs. 9.98 ± 2.44; p = 0.74), a lower myocardial SUV was noted in the fasted group (3.48 ± 1.73; p < 0.001). In contrast, the FDG uptake rate constant (Ki) for myocardium increased significantly by 47% in non-fasted mice by insulin (13.4 ± 3.9 ml/min/100 g vs. 19.8 ± 3.3 ml/min/100 g; p = 0.030); in fasted mice, a lower myocardial Ki as compared to controls was observed (3.3 ± 1.9 ml/min/100 g; p < 0.001). Skeletal muscle SUVs and Ki values were increased by insulin independent of dietary state, whereas in the brain, those parameters were not influenced by fasting or administration of insulin. Fasting led to a reduction in glucose metabolic rate in the myocardium (19.41 ± 5.39 vs. 3.26 ± 1.97 mg/min/100 g; p < 0.001), the skeletal muscle (1.06 ± 0.34 vs. 0.34 ± 0.08 mg/min/100 g; p = 0.001) but not the brain (3.21 ± 0.53 vs. 2.85 ± 0.25 mg/min/100 g; p = 0.19). Conclusions Changes in organ SUVs, uptake rate constants and metabolic rates induced by fasting and insulin administration as observed in intact mice by small-animal PET imaging are consistent with those observed in isolated heart/muscle preparations and, more importantly, in vivo studies in larger animals and in humans. When assessing the effect of insulin on the myocardial glucose metabolism of non-fasted mice, it is not sufficient to just calculate the SUV - dynamic imaging with kinetic modeling is necessary.

Published
2011

18. Sustainable development as an education tool for primary school students through SCRATCH code

Author

Tsikalakis Georgios, Neofotistou Eleftheria., Kontogiannakis Emmanouil., Pau Alonso-Monasterio, Caglayan Ercakir Mehmet, Fernandez-Canez Regina, and Perez-Accino Martinez

Subjects
Environmental sciences, GE1-350
Abstract

The concept of sustainable development is not only a scientific term but an essential way of changing the way of life for modern man. The cultivation of the values recommended by the UN through the 17 goals must become a pedagogical tool at all levels of education in order to achieve the most basic component of environmental education and sustainable development in the context of ESG, which is the process of recognizing values and clarifying concepts to develop the skills and attitudes necessary for understanding and appreciating the interrelationship of man, culture and the Biophysical environment. The project focus: a) on principles of software programming and pedagogical issues and b) on eco-social contextualization & dynamiting activities that can be applied with the students in order to create a pedagogical model through the use of Scratch code so that students can master knowledge through STEM methods.

Published
2023
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22. The PiCCO catheter

Author

Gassanov, N., Caglayan, E., Nia, A., Erdmann, E., Er, F., Gassanov, N., Caglayan, E., Nia, A., Erdmann, E., and Er, F.

Published
2010

34. Der PiCCO-Katheter

Author

Gassanov, N, primary, Caglayan, E, additional, Nia, A, additional, Erdmann, E, additional, and Er, F, additional

Published
2010
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44. Disruption of platelet-derived growth factor-dependent phosphatidylinositol 3-kinase and phospholipase Cγ 1 activity abolishes vascular smooth muscle cell proliferation and migration and attenuates neointima formation in vivo.

Author

Caglayan E, Vantler M, Leppänen O, Gerhardt F, Mustafov L, Ten Freyhaus H, Kappert K, Odenthal M, Zimmermann WH, Tallquist MD, Rosenkranz S, Caglayan, Evren, Vantler, Marius, Leppänen, Olli, Gerhardt, Felix, Mustafov, Lenard, Ten Freyhaus, Henrik, Kappert, Kai, Odenthal, Margarete, and Zimmermann, Wolfram H

Abstract

Objectives: We tested the hypothesis whether selective blunting of platelet-derived growth factor (PDGF)-dependent vascular smooth muscle cell (VSMC) proliferation and migration is sufficient to prevent neointima formation after vascular injury.Background: To prevent neointima formation and stent thrombosis after coronary interventions, it is essential to inhibit VSMC proliferation and migration without harming endothelial cell function. The role of PDGF-a potent mitogen and chemoattractant for VSMC that does not affect endothelial cells-for neointima formation remains controversial.Methods: To decipher the signaling pathways that control PDGF beta receptor (βPDGFR)-driven VSMC proliferation and migration, we characterized 2 panels of chimeric CSF1R/βPDGFR mutants in which the binding sites for βPDGFR-associated signaling molecules (Src, phosphatidylinositol 3-kinase [PI3K], GTPase activating protein of ras, SHP-2, phospholipase Cγ 1 [PLCγ]) were individually mutated. Based on in vitro results, the importance of PDGF-initiated signals for neointima formation was investigated in genetically modified mice.Results: Our results indicate that the chemotactic response to PDGF requires the activation of Src, PI3K, and PLCγ, whereas PDGF-dependent cell cycle progression is exclusively mediated by PI3K and PLCγ. These 2 signaling molecules contribute to signal relay of the βPDGFR by differentially regulating cyclin D1 and p27(kip1). Blunting of βPDGFR-induced PI3K and PLCγ signaling by a combination mutant (F3) completely abolished the mitogenic and chemotactic response to PDGF. Disruption of PDGF-dependent PI3K and PLCγ signaling in mice expressing the F3 receptor led to a profound reduction of neointima formation after balloon injury.Conclusions: Signaling by the activated βPDGFR, particularly through PI3K and PLCγ, is crucial for neointima formation after vascular injury. Disruption of these specific signaling pathways is sufficient to attenuate pathogenic processes such as vascular remodeling in vivo. [ABSTRACT FROM AUTHOR]

Published
2011
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45. Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases.

Author

Freyhaus HT, Dagnell M, Leuchs M, Vantler M, Berghausen EM, Caglayan E, Weissmann N, Dahal BK, Schermuly RT, Ostman A, Kappert K, Rosenkranz S, ten Freyhaus, Henrik, Dagnell, Markus, Leuchs, Maike, Vantler, Marius, Berghausen, Eva M, Caglayan, Evren, Weissmann, Norbert, and Dahal, Bhola K

Abstract

Rationale: Platelet-derived growth factor (PDGF) plays a pivotal role in the pathobiology of pulmonary hypertension (PH) because it promotes pulmonary vascular remodeling. PH is frequently associated with pulmonary hypoxia. Objectives: To investigate whether hypoxia alters PDGF β receptor (βPDGFR) signaling in the pulmonary vasculature. Methods: The impact of chronic hypoxia on signal transduction by the βPDGFR was measured in human pulmonary arterial smooth muscle cells (hPASMC) in vitro, and in mice with hypoxia-induced PH in vivo. Measurements and Main Results: Chronic hypoxia significantly enhanced PDGF-BB-dependent proliferation and chemotaxis of hPASMC. Pharmacologic inhibition of PI3 kinase (PI3K) and PLCγ abrogated these events under both normoxia and hypoxia. Although hypoxia did not affect βPDGFR expression, it increased the ligand-induced tyrosine phosphorylation of the receptor, particularly at binding sites for PI3K (Y751) and PLCγ (Y1021). The activated βPDGFR is dephosphorylated by protein tyrosine phosphatases (PTPs). Interestingly, hypoxia decreased expression of numerous PTPs (T cell PTP, density-enhanced phosphatase-1, PTP1B, and SH2 domain-containing phosphatase-2), resulting in reduced PTP activity. Hypoxia-inducible factor (HIF)-1α is involved in this regulation of gene expression, because hypoxia-induced βPDGFR hyperphosphorylation and PTP down-regulation were abolished by HIF-1α siRNA and by the HIF-1α inhibitor 2-methoxyestradiol. βPDGFR hyperphosphorylation and PTP down-regulation were also present in vivo in mice with chronic hypoxia-induced PH. Conclusions: Hypoxia reduces expression and activity of βPDGFR-antagonizing PTPs in a HIF-1α-dependent manner, thereby enhancing receptor activation and proliferation and chemotaxis of hPASMC. Because hyperphosphorylation of the βPDGFR and down-regulation of PTPs occur in vivo, this mechanism likely has significant impact on the development and progression of PH and other hypoxia-associated diseases. [ABSTRACT FROM AUTHOR]

Published
2011
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46. Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis.

Author

Caglayan E, Stauber B, Collins AR, Lyon CJ, Yin F, Liu J, Rosenkranz S, Erdmann E, Peterson LE, Ross RS, Tangirala RK, Hsueh WA, Caglayan, Evren, Stauber, Bradley, Collins, Alan R, Lyon, Christopher J, Yin, Fen, Liu, Joey, Rosenkranz, Stephan, and Erdmann, Erland

Abstract

Objective: Cardiac fibrosis is an important component of diabetic cardiomyopathy. Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands repress proinflammatory gene expression, including that of osteopontin, a known contributor to the development of myocardial fibrosis. We thus investigated the hypothesis that PPARgamma ligands could attenuate cardiac fibrosis.Research Design and Methods: Wild-type cardiomyocyte- and macrophage-specific PPARgamma(-/-) mice were infused with angiotensin II (AngII) to promote cardiac fibrosis and treated with the PPARgamma ligand pioglitazone to determine the roles of cardiomyocyte and macrophage PPARgamma in cardiac fibrosis.Results: Cardiomyocyte-specific PPARgamma(-/-) mice (cPPARgamma(-/-)) developed spontaneous cardiac hypertrophy with increased ventricular osteopontin expression and macrophage content, which were exacerbated by AngII infusion. Pioglitazone attenuated AngII-induced fibrosis, macrophage accumulation, and osteopontin expression in both wild-type and cPPARgamma(-/-) mice but induced hypertrophy in a PPARgamma-dependent manner. We pursued two mechanisms to explain the antifibrotic cardiomyocyte-PPARgamma-independent effects of pioglitazone: increased adiponectin expression and attenuation of proinflammatory macrophage activity. Adenovirus-expressed adiponectin had no effect on cardiac fibrosis and the PPARgamma ligand pioglitazone did not attenuate AngII-induced cardiac fibrosis, osteopontin expression, or macrophage accumulation in monocyte-specific PPARgamma(-/-) mice.Conclusions: We arrived at the following conclusions: 1) both cardiomyocyte-specific PPARgamma deficiency and activation promote cardiac hypertrophy, 2) both cardiomyocyte and monocyte PPARgamma regulate cardiac macrophage infiltration, 3) inflammation is a key mediator of AngII-induced cardiac fibrosis, 4) macrophage PPARgamma activation prevents myocardial macrophage accumulation, and 5) PPARgamma ligands attenuate AngII-induced cardiac fibrosis by inhibiting myocardial macrophage infiltration. These observations have important implications for potential interventions to prevent cardiac fibrosis. [ABSTRACT FROM AUTHOR]

Published
2008
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47. Simulation of Biomass and/or Coal Gasification Systems Integrated With Fuel Cells

Author

Ersoz, A., Ozdogan, S., Caglayan, E., and Olgun, H.

Abstract

This paper presents the results of a system simulation study. The HYSYS 3.1 - ASPEN code has been used for simulation. The system consists of a fixed bed gasifier followed by reforming and clean-up units. The produced hydrogen gas is fed to a PEM fuel cell. The gasified hydrocarbons are hazelnut shells, bark, rice straw, animal waste, and two lignites. Hydrocarbon properties, gasification, and reforming process parameters all affect the system efficiency. The effect of the moisture content and oxygen to carbon ratio of the hydrocarbon feeds on the fuel processing and overall system efficiencies are presented. The overall efficiency of the system increases with increasing hydrocarbon feed oxygen to carbon ratio; this tendency is more evident at higher moisture levels.

Published
2006
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49. Poster Session Saturday 14 December - AM: 14/12/2013, 08:30-12:30 * Location: Poster area

Author

Muraru, D, Addetia, K, Veronesi, F, Corsi, C, Mor-Avi, V, Yamat, M, Weinert, L, Lang, RM, Badano, LP, Faita, F, Di Lascio, N, Bruno, RM, Bianchini, E, Ghiadoni, L, Sicari, R, Gemignani, V, Angelis, A, Ageli, K, Ioakimidis, N, Chrysohoou, C, Agelakas, A, Felekos, I, Vaina, S, Aznaourides, K, Vlachopoulos, C, Stefanadis, C, Nemes, A, Szolnoky, G, Gavaller, H, Gonczy, A, Kemeny, L, Forster, T, Ramalho, A, Placido, R, Marta, L, Menezes, M, Magalhaes, A, Cortez Dias, N, Martins, S, Almeida, A, Pinto, F, Nunes Diogo, A, Botezatu, C-D, Enache, R, Popescu, BA, Nastase, O, Coman, MC, Ghiorghiu, I, Calin, A, Rosca, M, Beladan, C, Ginghina, C, Grapsa, J, Cabrita, IZ, Durighel, G, Oregan, D, Dawson, D, Nihoyannopoulos, P, Pellicori, P, Kallvikbacka-Bennett, A, Zhang, J, Lukaschuk, E, Joseph, A, Bourantas, C, Loh, H, Bragadeesh, T, Clark, A, Cleland, JG, Kallvikbacka-Bennett, A, Pellicori, P, Lomax, S, Putzu, P, Diercx, R, Parsons, S, Dicken, B, Zhang, J, Clark, A, Cleland, JG, Vered, Z, Adirevitz, L, Dragu, R, Blatt, A, Karev, E, Malca, Y, Roytvarf, A, Marek, D, Sovova, E, Berkova, M, Cihalik, C, Taborsky, M, Lindqvist, P, Tossavainen, ERIK, Soderberg, S, Gonzales, M, Gustavsson, S, Henein, MY, Sonne, C, Bott-Fluegel, L, Hauck, S, Lesevic, H, Hadamitzky, M, Wolf, P, Kolb, C, Bandera, F, Pellegrino, M, Generati, G, Donghi, V, Alfonzetti, E, Castelvecchio, S, Menicanti, L, Guazzi, M, Buchyte, S, Rinkuniene, D, Jurkevicius, R, Smarz, K, Zaborska, B, Jaxa-Chamiec, T, Maciejewski, P, Budaj, A, Santoro, A, Federico Alvino, FA, Giovanni Antonelli, GA, Roberta Molle, RM, Matteo Bertini, MB, Stefano Lunghetti, SL, Sergio Mondillo, SM, Henri, C, Magne, J, Dulgheru, R, Laaraibi, S, Voilliot, D, Kou, S, Pierard, L, Lancellotti, P, Szulik, M, Stabryla-Deska, J, Kalinowski, M, Sliwinska, A, Szymala, M, Lenarczyk, R, Kalarus, Z, Kukulski, T, Investigators, TRUST CRT, Yiangou, K, Azina, C, Yiangou, A, Ioannides, M, Chimonides, S, Baysal, S, Pirat, B, Okyay, K, Bal, U, Muderrisoglu, H, Popovic, D, Ostojic, M, Petrovic, M, Vujisic-Tesic, B, Arandjelovic, A, Petrovic, I, Banovic, M, Popovic, B, Vukcevic, V, Damjanovic, S, Velasco Del Castillo, S, Onaindia Gandarias, JJ, Arana Achaga, X, Laraudogoitia Zaldumbide, E, Rodriguez Sanchez, I, Cacicedo De Bobadilla, A, Romero Pereiro, A, Aguirre Larracoechea, U, Salinas, T, Subinas, A, Elzbieciak, M, Wita, K, Grabka, M, Chmurawa, J, Doruchowska, A, Turski, M, Filipecki, A, Wybraniec, M, Mizia-Stec, K, Varho, VV, Karjalainen, PP, Lehtinen, T, Airaksinen, JKE, Ylitalo, A, Kiviniemi, TO, Gargiulo, P, Galderisi, M, D Amore, C, Lo Iudice, F, Savarese, G, Casaretti, L, Pellegrino, AM, Fabiani, I, La Mura, L, Perrone Filardi, P, Kim, J Y, Chung, WB, Yu, JS, Choi, YS, Park, CS, Youn, HJ, Lee, MY, Nagy, AI, Manouras, A, Gunyeli, E, Gustafsson, U, Shahgaldi, K, Winter, R, Johnsson, J, Zagatina, A, Krylova, L, Zhuravskaya, N, Vareldzyan, Y, Tyurina, TV, Clitsenko, O, Khalifa, E A, Ashour, Z, Elnagar, W, Jung, IH, Seo, HS, Lee, SJ, Lim, DS, Mizariene, V, Verseckaite, R, Janenaite, J, Jonkaitiene, R, Jurkevicius, R, Sanchez Espino, AD, Bonaque Gonzalez, JC, Merchan Ortega, G, Bolivar Herrera, N, Ikuta, I, Macancela Quinones, JJ, Gomez Recio, M, Silva Fazendas Adame, P R, Caldeira, D, Stuart, B, Almeida, S, Cruz, I, Ferreira, A, Freire, G, Lopes, L, Cotrim, C, Pereira, H, Mediratta, A, Addetia, K, Moss, JD, Nayak, HM, Yamat, M, Weinert, L, Mor-Avi, V, Lang, RM, Al Amri, I, Debonnaire, P, Van Der Kley, F, Schalij, MJ, Bax, JJ, Ajmone Marsan, N, Delgado, V, Schmidt, F P, Gniewosz, T, Jabs, A, Munzel, T, Jansen, T, Kaempfner, D, Hink, U, Von Bardeleben, RS, Jose, J, George, OK, Joseph, G, Jose, J, Adawi, S, Najjar, R, Ahronson, D, Shiran, A, Van Riel, ACMJ, Boerlage - Van Dijk, K, De Bruin - Bon, HACM, Araki, M, Meregalli, PG, Koch, KT, Vis, MM, Mulder, BJM, Baan, J, Bouma, BJ, Marciniak, A, Elton, D, Glover, K, Campbell, I, Sharma, R, Batalha, S, Lourenco, C, Oliveira Da Silva, C, Manouras, A, Shahgaldi, K, Caballero, L, Garcia-Lara, J, Gonzalez-Carrillo, J, Oliva, MJ, Saura, D, Garcia-Navarro, M, Espinosa, MD, Pinar, E, Valdes, M, De La Morena, G, Barreiro Perez, M, Lopez Perez, M, Roy, D, Brecker, S, Sharma, R, Venkateshvaran, A, Dash, P K, Sola, S, Barooah, B, Govind, S C, Winter, R, Shahgaldi, K, Brodin, L A, Manouras, A, Saura Espin, D, Caballero Jimenez, L, Gonzalez Carrillo, J, Oliva Sandoval, MJ, Lopez Ruiz, M, Garcia Navarro, M, Espinosa Garcia, MD, Valdes Chavarri, M, De La Morena Valenzuela, G, Gatti, G, Dellangela, L, Pinamonti, B, Benussi, B, Sinagra, G, Pappalardo, A, Group, Heart Muscle Disease Study, Hernandez, V, Saavedra, J, Gonzalez, A, Iglesias, P, Civantos, S, Guijarro, G, Monereo, S, Ikeda, M, Toh, N, Oe, H, Tanabe, Y, Watanabe, N, Ito, H, Ciampi, Q, Cortigiani, L, Pratali, L, Rigo, F, Villari, B, Picano, E, Sicari, R, Yoon, JH, Sohn, JW, Kim, YJ, Chang, HJ, Hong, GR, Kim, TH, Ha, JW, Choi, BW, Rim, SJ, Choi, EY, Tibazarwa, K, Sliwa, K, Wonkam, A, Mayosi, BM, Oryshchyn, N, Ivaniv, Y, Pavlyk, S, Lourenco, M R, Azevedo, O, Moutinho, J, Nogueira, I, Fernandes, M, Pereira, V, Quelhas, I, Lourenco, A, Sunbul, M, Tigen, K, Karaahmet, T, Dundar, C, Ozben, B, Guler, A, Cincin, A, Bulut, M, Sari, I, Basaran, Y, Baydar, O, Kadriye Kilickesmez, KK, Ugur Coskun, UC, Polat Canbolat, PC, Veysel Oktay, VO, Umit Yasar Sinan, US, Okay Abaci, OA, Cuneyt Kocas, CK, Sinan Uner, SU, Serdar Kucukoglu, SK, Zaroui, A, Mourali, MS, Ben Said, R, Asmi, M, Aloui, H, Kaabachi, N, Mechmeche, R, Saberniak, J, Hasselberg, NE, Borgquist, R, Platonov, PG, Holst, AG, Edvardsen, T, Haugaa, KH, Lourenco, M R, Azevedo, O, Nogueira, I, Moutinho, J, Fernandes, M, Pereira, V, Quelhas, I, Lourenco, A, Eran, A, Yueksel, D, Er, F, Gassanov, N, Rosenkranz, S, Baldus, S, Guedelhoefer, H, Faust, M, Caglayan, E, Matveeva, N, Nartsissova, G, Chernjavskij, A, Ippolito, R, De Palma, D, Muscariello, R, Santoro, C, Raia, R, Schiano-Lomoriello, V, Gargiulo, F, Galderisi, M, Lipari, P, Bonapace, S, Zenari, L, Valbusa, F, Rossi, A, Lanzoni, L, Canali, G, Molon, G, Campopiano, E, Barbieri, E, Ikonomidis, I, Varoudi, M, Papadavid, E, Theodoropoulos, K, Papadakis, I, Pavlidis, G, Triantafyllidi, H, Anastasiou - Nana, M, Rigopoulos, D, Lekakis, J, Sunbul, M, Tigen, K, Ozen, G, Durmus, E, Kivrak, T, Cincin, A, Ozben, B, Atas, H, Direskeneli, H, Basaran, Y, Stevanovic, A, Dekleva, M, Trajic, S, Paunovic, N, Simic, A, Khan, SG, Mushemi-Blake, S, Jouhra, F, Dennes, W, Monaghan, M, Melikian, N, Shah, AM, Division, Cardiovascular, Excellence, King’s BHF Centre of, Maceira Gonzalez, A M, Lopez-Lereu, MP, Monmeneu, JV, Igual, B, Estornell, J, Boraita, A, Kosmala, W, Rojek, A, Bialy, D, Mysiak, A, Przewlocka-Kosmala, M, Popescu, I, Mancas, S, Mornos, C, Serbescu, I, Ionescu, G, Ionac, A, Gaudron, P, Niemann, M, Herrmann, S, Hu, K, Liu, D, Wojciech, K, Frantz, S, Bijnens, B, Ertl, G, Weidemann, F, Maceira Gonzalez, A M, Cosin-Sales, J, Ruvira, J, Diago, JL, Aguilar, J, Igual, B, Lopez-Lereu, MP, Monmeneu, J, Estornell, J, Cruz, C, Pinho, T, Madureira, AJ, Lebreiro, A, Dias, CC, Ramos, I, Silva Cardoso, J, Julia Maciel, M, De Meester, P, Van De Bruaene, A, Herijgers, P, Voigt, J-U, Budts, W, Franzoso, F, Voser, EM, Wohlmut, C, Kellenberger, CJ, Valsangiacomo Buechel, E, Carrero, C, Benger, J, Parcerisa, MF, Falconi, M, Oberti, PF, Granja, M, Cagide, AM, Del Pasqua, A, Secinaro, A, Antonelli, G, Iacomino, M, Toscano, A, Chinali, M, Esposito, C, Carotti, A, Pongiglione, G, Rinelli, G, Youssef Moustafa, A, Al Murayeh, M, Al Masswary, A, Al Sheikh, K, Moselhy, M, Dardir, MD, Deising, J, Butz, T, Suermeci, G, Liebeton, J, Wennemann, R, Tzikas, S, Van Bracht, M, Prull, MW, Trappe, H-J, Martin Hidalgo, M, Delgado Ortega, M, Ruiz Ortiz, M, Mesa Rubio, D, Carrasco Avalos, F, Seoane Garcia, T, Pan Alvarez-Ossorio, M, Lopez Aguilera, J, Puentes Chiachio, M, Suarez De Lezo Cruz Conde, J, Petrovic, M T, Giga, V, Stepanovic, J, Tesic, M, Jovanovic, I, Djordjevic-Dikic, A, Generati, G, Pellegrino, M, Bandera, F, Donghi, V, Alfonzetti, E, Guazzi, M, Piatkowski, R, Kochanowski, J, Scislo, P, Opolski, G, Zagatina, A, Zhuravskaya, N, Krylova, L, Vareldzhyan, Y, Tyurina, TV, Clitsenko, O, Bombardini, T, Gherardi, S, Leone, O, Picano, E, Michelotto, E, Ciccarone, A, Tarantino, N, Ostuni, V, Rubino, M, Genco, W, Santoro, G, Carretta, D, Romito, R, Colonna, P, foundation, Cassa di Risparmio di Puglia, Cameli, M, Lunghetti, S, Lisi, M, Curci, V, Cameli, P, Focardi, M, Favilli, R, Galderisi, M, Mondillo, S, Hoffmann, R, Barletta, G, Von Bardeleben, S, Kasprzak, J, Greis, C, Vanoverschelde, J, Becher, H, Machida, T, Izumo, M, Suzuki, K, Kaimijima, R, Mizukoshi, K, Manabe-Uematsu, M, Takai, M, Harada, T, Akashi, YJ, Medicine., St. Marianna University School of, Cardiology, Division of, Martin Garcia, A, Arribas-Jimenez, A, Cruz-Gonzalez, I, Nieto, F, Iscar, A, Merchan, S, Martin-Luengo, C, Brecht, A, Theres, L, Spethmann, S, Dreger, H, Baumann, G, Knebel, F, Jasaityte, R, Heyde, B, Rademakers, F, Claus, P, Dhooge, J, Lervik Nilsen, L C, Lund, J, Brekke, B, Stoylen, A, Giraldeau, G, Duchateau, N, Gabrielli, L, Penela, D, Evertz, R, Mont, L, Brugada, J, Berruezo, A, Bijnens, BH, Sitges, M, Kordybach, M, Kowalski, M, Hoffman, P, Pilichowska, E, Zaborska, B, Baran, J, Kulakowski, P, Budaj, A, Wahi, S, Vollbon, W, Leano, R, Thomas, A, Bricknell, K, Holland, D, Napier, S, Stanton, T, Teferici, D, Qirko, S, Petrela, E, Dibra, A, Bajraktari, G, Bara, P, Sanchis Ruiz, L, Gabrielli, L, Andrea, R, Falces, C, Duchateau, N, Perez-Villa, F, Bijnens, B, Sitges, M, Sulemane, S, Panoulas, VF, Bratsas, AH, Tam, FW, Nihoyannopoulos, P, Abduch, MCD, Alencar, AM, Coracin, FL, Barban, A, Saboya, R, Dulley, FL, Mathias, W, Vieira, MLC, Buccheri, S, Mangiafico, S, Arcidiacono, A, Bottari, VE, Leggio, S, Tamburino, C, Monte, I P, Cruz, C, Lebreiro, A, Pinho, T, Dias, CC, Silva Cardoso, J, Julia Maciel, M, Spitzer, E, Beitzke, D, Kaneider, A, Pavo, N, Gottsauner-Wolf, M, Wolf, F, Loewe, C, Mushtaq, S, Andreini, D, Pontone, G, Bertella, E, Conte, E, Baggiano, A, Annoni, A, Cortinovis, S, Fiorentini, C, Pepi, M, Gustafsson, M, Alehagen, U, Dahlstrom, U, Johansson, P, Faden, G, Faggiano, P, Albertini, L, Reverberi, C, Gaibazzi, N, Taylor, R J, Moody, WE, Umar, F, Edwards, NC, Townend, JN, Steeds, RP, Leyva, F, Mihaila, S, Muraru, D, Piasentini, E, Peluso, D, Casablanca, S, Naso, P, Puma, L, Iliceto, S, Vinereanu, D, Badano, LP, Ciciarello, F L, Agati, L, Cimino, S, De Luca, L, Petronilli, V, Fedele, F, and Tsverava, M

Abstract

Purpose: Transthoracic 3D echocardiography (3DE) allows an unparalleled opportunity for quantifying the dynamic changes of the tricuspid annulus (TA). Accordingly, our aims were: (I) to assess the determinants of TA size during cardiac cycle in healthy subjects; (II) to propose an approach and timing for TA sizing using 3DE. Methods: In 50 healthy volunteers (45±14 yrs, range 18-74, 27 males, with no risk factors, symptoms, signs or history of cardiovascular disease and on no medication), a full-volume dataset of the right ventricle (RV) containing the tricuspid valve (TV) was acquired (Vivid E9, GE Healthcare). TA diameters (septo-lateral, SL; antero-posterior, AP) and areas were measured on multiplanar images (Flexi-slice, EchoPac BT12, GE Healthcare) at 5 time points during the cardiac cycle: OS (onset of systole, at TV closure); MS (mid-systole); ES (end-systole); ED (onset of diastole); LD (late diastole, after the P wave). RV volumes and ejection fraction (EF) were analyzed with commercial software (4D RV analysis, TomTec, D). Results: Temporal resolution of the 3D datasets was 32±4 vps (range 24-53). TA areas were more closely correlated with RV volumes and body surface area (BSA) than with either SL or AP diameters. TA areas increased during systole from OS (3.9±0.6 cm2/m2) to ES (4.9±0.8 cm2/m2) and reached its largest area in LD (6.7±1.0 cm2/m2). All 5 TA areas were correlated with BSA (r range 0.57-0.62) and RV volumes (r ranges 0.53-0.60 for end-diastolic volume and 0.43-0.50 for end-systolic volume, p<0.0001 for all). Indexed TA areas were not related to either age or gender. With multivariable analysis, both RV end-diastolic volume and BSA determined TA areas during systole and early diastole, while TA area at LD and at OS were independently related with BSA only. Conclusions: In healthy subjects, the main determinants of TA size are RV volume and BSA. The largest TA area occurs at LD and is independently related with BSA only. Therefore, normative values should be based on TA areas measured at LD and indexed for BSA. However, the rapid change in TA areas occurring from LD to OS underscores the importance of adequate temporal resolution of 3DE data sets for reliable TA measurements.

Published
2013
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50. PHYTOPLASMAS INFECTING FRUIT TREES IN SERBIA

Author

Milan Ivanović, Bojan Duduk, Samanta Paltrinieri, Assunta Bertaccini, K. CAGLAYAN E F. ERTUNC, B. Duduk, S. Paltrinieri, M. Ivanović, and A. Bertaccini

Subjects
disease, food and beverages, apple, pear, Horticulture, Biology, DISEASE, peach, PCR/RFLP ANALYSES, APPLE, Botany, PEAR, PCR/RFLP analyses, apricot, PEACH
Abstract

During 2003–2005 extensive surveys were carried out in diverse location in Serbia to verify phytoplasma presence in fruit trees species affected by decline, reddening, yellowing or witches’ broom symptoms. Tests were carried out using PCR/RFLP analyses to detect phytoplasma presence and to determine their identity. European stone fruit yellows phytoplasmas (16SrX-B) were identified in apricot plants showing typical chlorotic leaf roll symptoms and in samples collected from peach plants showing general decline together with yellowing and reddening of leaves. In other samples from peaches with similar symptoms, stolbur (16SrXII-A) phytoplasmas were detected. Two different symptoms were associated with diverse phytoplasmas in pear: pear decline (16SrX-C) phytoplasmas were identified in samples from plants showing typical decline symptoms, while X-disease (16SrIII-B) phytoplasmas were identified in a pear plant showing witches’ broom and reduced growth. Samples from apple showing symptoms of proliferation, witches’ broom and reduced fruit size, resulted to be infected by apple proliferation (16SrX-A) phytoplasmas.

Published
2008

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