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12 results on '"Cai, Baowei"'

5. Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality

Author

Yu, Xiao, primary, Cai, Baowei, additional, Wang, Mingjun, additional, Tan, Peng, additional, Ding, Xilai, additional, Wu, Jian, additional, Li, Jian, additional, Li, Qingtian, additional, Liu, Pinghua, additional, Xing, Changsheng, additional, Wang, Helen Y., additional, Su, Xin-zhuan, additional, and Wang, Rong-Fu, additional

Published
2016
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6. Genome-Wide Interactions of Mouse-Plasmodium yoelii Parasite and Identification of Regulators of Type I Interferon Response

Author

Wu, Jian, Cai, Baowei, Sun, Wenxiang, Huang, Ruili, Liu, Xueqiao, Lin, Meng, Pattaradilokrat, Sittiporn, Martin, Scott, Qi, Yanwei, Nair, Sethu C., Bolland, Silvia, Cohen, Jeffrey I., Austin, Christopher P., Long, Carole A., Myers, Timothy G., Wang, Rong-fu, and Su, Xin-zhuan

Subjects
Mice, Inbred C57BL, Mice, Interferon Type I, Quantitative Trait Loci, Animals, Plasmodium yoelii, Genome, Protozoan, Article, Genome-Wide Association Study, Host-Parasite Interactions, Malaria
Abstract

Invading pathogens trigger specific host responses, an understanding of which might identify genes that function in pathogen recognition and elimination. In this study, we performed trans-species expression quantitative trait locus (ts-eQTL) analysis using genotypes of the Plasmodium yoelii malaria parasite and phenotypes of mouse gene expression. We significantly linked 1,054 host genes to parasite genetic loci (LOD score ≥ 3.0). Using LOD score patterns, which produced results that differed from direct expression-level clustering, we grouped host genes that function in related pathways, allowing functional prediction of unknown genes. As a proof of principle, 14 of 15 randomly selected genes predicted to function in type I interferon (IFN-I) responses were experimentally validated using overexpression, small hairpin RNA knockdown, viral infection, and/or infection of knockout mice. This study demonstrates an effective strategy for studying gene function, establishes a functional gene database, and identifies regulators in IFN-I pathways.

Published
2015

8. Genome-wide Analysis of Host-Plasmodium yoelii Interactions Reveals Regulators of the Type I Interferon Response

Author

Wu, Jian, primary, Cai, Baowei, additional, Sun, Wenxiang, additional, Huang, Ruili, additional, Liu, Xueqiao, additional, Lin, Meng, additional, Pattaradilokrat, Sittiporn, additional, Martin, Scott, additional, Qi, Yanwei, additional, Nair, Sethu C., additional, Bolland, Silvia, additional, Cohen, Jeffrey I., additional, Austin, Christopher P., additional, Long, Carole A., additional, Myers, Timothy G., additional, Wang, Rong-Fu, additional, and Su, Xin-zhuan, additional

Published
2015
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11. Multi-Strain Infections and ‘Relapse’ of Leucocytozoon sabrazesi Gametocytes in Domestic Chickens in Southern China.

Author

Zhao, Wenting, Cai, Baowei, Qi, Yanwei, Liu, Shengfa, Hong, Lingxian, Lu, Mingke, Chen, Xin, Qiu, Chunhui, Peng, Wenfeng, Li, Jian, and Su, Xin-zhuan

Subjects
*LEUCOCYTOZOON, *GERM cells, *DISEASE relapse, *CHICKEN diseases, *PARASITIC diseases
Abstract

Leucocytozoon parasites infect many species of avian hosts, including domestic chicken, and can inflict heavy economic loss to the poultry industry. Although the prevalence and distribution of two Leucocytozoon species (L. sabrazesi and L. caulleryi) have been reported in China previously, there are many questions related to the parasite infection that remain unanswered, including population diversity and transmission dynamics in domestic chickens. Here we surveyed chicken blood samples from seven sites in four provinces of China to identify Leucocytozoon infection, characterized parasite diversity within individual infected hosts and between sampling sites, and investigated the dynamics of gametocytemia in chickens over time. We found high infection rates in three of the seven sites. Clustering parasite sequences of the mitochondrial cytochrome oxidase III (coxIII) and cytochrome b (cytb) genes showed lack of grouping according to geographic origins and individual hosts carrying large numbers of L. sabrazesi strains. Monitoring gametocytemia in blood samples from infected chickens over time showed ‘relapse’ or persistence of low-level gametocytemia for 4–5 months, which could be explored as an in vivo model for testing drugs against liver stages of Apicomplexan parasites. This study provides important information on population diversity and transmission dynamics of L. sabrazesi and for disease control. [ABSTRACT FROM AUTHOR]

Published
2014
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12. Genome-wide Analysis of Host-Plasmodium yoeliiInteractions Reveals Regulators of the Type I Interferon Response

Author

Wu, Jian, Cai, Baowei, Sun, Wenxiang, Huang, Ruili, Liu, Xueqiao, Lin, Meng, Pattaradilokrat, Sittiporn, Martin, Scott, Qi, Yanwei, Nair, Sethu C., Bolland, Silvia, Cohen, Jeffrey I., Austin, Christopher P., Long, Carole A., Myers, Timothy G., Wang, Rong-Fu, and Su, Xin-zhuan

Abstract

Invading pathogens trigger specific host responses, an understanding of which might identify genes that function in pathogen recognition and elimination. In this study, we performed trans-species expression quantitative trait locus (ts-eQTL) analysis using genotypes of the Plasmodium yoeliimalaria parasite and phenotypes of mouse gene expression. We significantly linked 1,054 host genes to parasite genetic loci (LOD score ≥ 3.0). Using LOD score patterns, which produced results that differed from direct expression-level clustering, we grouped host genes that function in related pathways, allowing functional prediction of unknown genes. As a proof of principle, 14 of 15 randomly selected genes predicted to function in type I interferon (IFN-I) responses were experimentally validated using overexpression, small hairpin RNA knockdown, viral infection, and/or infection of knockout mice. This study demonstrates an effective strategy for studying gene function, establishes a functional gene database, and identifies regulators in IFN-I pathways.

Published
2015
Full Text
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