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26 results on '"Cai, Mengtan"'

13. Elevated Blood S100B Levels in Patients With Migraine: A Systematic Review and Meta-Analysis

Author

Chu, Chaojia, Zhong, Rui, Cai, Mengtan, Li, Nan, and Lin, Weihong

Subjects
Neurology, Neurology (clinical)
Abstract

Background:In recent years, a growing number of researches indicate that S100B may act in migraine, but the relationship between S100B and migraine remains controversial. Therefore, the current study aimed to perform a meta-analysis to quantitatively summarize S100B levels in migraine patients.MethodsWe used Stata 12.0 software to summarize eligible studies from PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang databases. We applied standardized mean differences (SMDs) with 95% confidence intervals (95%CIs) to appraise the association between S100B and migraine.ResultsThe combined results of nine case-control studies indicated that compared with healthy controls, overall migraine patients had significantly increased S100B levels in peripheral blood (SMD = 0.688, 95%CI: 0.341–1.036, P < 0.001). The S100B levels in migraineurs during ictal periods (SMD =1.123, 95%CI: 0.409–1.836, P = 0.002) and interictal periods (SMD = 0.487, 95%CI: 0313–0.661, P < 0.001), aura (SMD = 0.999, 95%CI: 0.598–1.400, P < 0.001) and without aura (SMD = 0.534, 95%CI: 0.286–0.783, P < 0.001) were significantly higher than those in the controls. The subgroup analyses by age, country, migraine assessment, and assay method of S100B also illustrated a statistically obvious association between S100B levels and migraine, indicating that age may be the most important source of heterogeneity. Sensitivity analysis showed that no individual study has a significant influence on the overall association between S100B and migraine.ConclusionThis meta-analysis demonstrates that the level of S100B in peripheral blood of patients with migraine was significantly increased. Migraine may be associated with pathological reactions involving S100B, which is instrumental for the clinical diagnosis of migraine and therapy that considers S100B as a potential target.

Published
2022
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15. Effects of copolymer component on the properties of phosphorylcholine micelles

Author

Wu,Zhengzhong, Cai,Mengtan, Cao,Jun, Zhang,Jiaxing, Luo,Xianglin, Wu,Zhengzhong, Cai,Mengtan, Cao,Jun, Zhang,Jiaxing, and Luo,Xianglin

Abstract

Zhengzhong Wu,1 Mengtan Cai,1 Jun Cao,2 Jiaxing Zhang,1 Xianglin Luo1,3 1College of Polymer Science and Engineering, 2National Engineering Research Center for Biomaterials, 3State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, People’s Republic of China Abstract: Zwitterionic polymers have unique features, such as good compatibility, and show promise in the application of drug delivery. In this study, the zwitterionic copolymers, poly(ε-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine) with disulfide (PCL-ss-PMPC) or poly(ε-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine) or without disulfide (PCL-PMPC) and with different block lengths in PCL-ss-PMPC, were designed. The designed copolymers were obtained by a combination of ring-opening polymerization and atom transferring radical polymerization. The crystallization properties of these polymers were investigated. The micelles were prepared based on the obtained copolymers with zwitterionic phosphorylcholine as the hydrophilic shell and PCL as the hydrophobic core. The size distributions of the blank micelles and the doxorubicin (DOX)-loaded micelles were uniform, and the micelle diameters were <100 nm. In vitro drug release and intracellular drug release results showed that DOX-loaded PCL-ss-PMPC micelles could release drugs faster responding to the reduction condition and the intracellular microenvironment in contrast to PCL-PMPC micelles. Moreover, in vitro cytotoxicity evaluation revealed that the designed copolymers possessed low cell toxicity, and the inhibiting effect of DOX-loaded phosphorylcholine micelles to tumor cells was related to the components of these copolymers. These results reveal that the reduction-responsive phosphorylcholine micelles with a suitable ratio of hydrophilic/hydrophobic units can serve as promising drug carriers. Keywords: zwitterionic, reduction-sensitive, disulfide, phosphory

Published
2017

26. In situ chemically crosslinked chitosan membrane by adipic acid.

Author

Cai, Mengtan, Gong, Jiang, Cao, Jun, Chen, Yuanwei, and Luo, Xianglin

Subjects
CHITOSAN, ADIPIC acid, X-ray diffraction, X-ray diffractometers, ALKALINE solutions, COMPUTER software
Abstract

Adipic acid, which is nontoxic, was used to dissolve chitosan. The chitosan/adipic acid solution was used to prepare chitosan membrane. After being heated at 80-100°C, the membrane was in situ chemically crosslinked by adipic acid, as verified by Fourier transform infrared and wide-angle X-ray diffractometer analysis. The crosslinked membrane did not collapse even without treatment in alkaline solution. In addition, the in situ crosslinking reaction was studied. The crosslinking degree (CLD) was quantitatively calculated based on the mass of water produced. The results showed that CLD was positively related to both heating temperature and time. Results of kinetic of crosslinking reaction suggested that the amidation was in agreement with the first-order rate equation and that the temperature effect could be described with the Arrhenius equation. The results of weight loss of chitosan membrane in phosphate-buffered solution (pH = 7.4) indicated that the best water resistance of chitosan membrane was obtained at 90°C. In brief, a straightforward, nontoxic, environment-friendly, and economical chemically crosslinking approach has been developed for chitosan materials. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 [ABSTRACT FROM AUTHOR]

Published
2013
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