Search

Black phosphorus (BP) is a narrow bandgap layered semiconductor promising for mid-infrared optoelectronic applications. BP-based devices have been shown to surpass state-of-the-art mid-infrared detectors and light-emitting diodes (LEDs) in terms of performance. Despite their device advantages, the material's inherent instability in the air could hinder its use in practical optoelectronic applications. Here, we investigated the impact of passivation on the device lifetime of BP LEDs, which deteriorate in a matter of seconds without using passivation. The lifetime is significantly extended with an Al2O3 passivation layer and nitrogen packaging via atomic layer deposition and ultra-violet curable resin sealing. The operational lifetime (half-life) at room temperature is extrapolated to be ~15,000 h with an initial power density of 340 mW/cm2 based on accelerated life testing. The present results indicate that efficient BP optoelectronics can be highly robust through simple and scalable packaging technologies, with important practical implications for mid-infrared applications.

Developing efficient electrocatalysts is very important for water electrolysis technology to deal with the energy crisis. The oxygen evolution reaction (OER) in the semireaction of electrolytic water is a crucial step. Herein, we report a facial strategy to fabricate the bird nest-like Fe3O4/CoOx (BN-Fe3O4/CoOx) nanosphere heterojunctions with amorphous/crystalline (a/c) structure through cation-exchange and subsequent calcination treatment in a reducing Ar/H2 atmosphere. Owing to its unique structure and the electron state near the heterogeneous interface, the BN-Fe3O4/CoOx nanosphere exhibits a very competitive overpotential of 286 mV at the current density of 10 mA cm–2 for OER with a low Tafel slope of 55.51 mV dec–1 in 1.0 M KOH, and long-term durability for more than 20 h. This work may provide an idea and a convenient method for the preparation of a/c-heterostructure electrocatalysts. [ABSTRACT FROM AUTHOR]

Glioblastoma multiforme (GBM) heterogeneity causes a greater number of deaths than any other brain tumor, despite the availability of alkylating chemotherapy. GBM stem-like cells (GSCs) contribute to GBM complexity and chemoresistance, but It remains challenging to Identify and target GSCs or factors that control their activity. Here, we Identified a specific GSC subset and show that activity of these cells Is positively regulated by stabilization of methyl CpG binding domain 3 (MBD3) protein. MBD3 binds to CK1A and to BTRCP E3 ubiquitin ligase, triggering MBD3 degradation, suggesting that modulating this circuit could antagonize GBM recurrence. Accordingly, xenograft mice treated with the CK1A activator pyrvinium pamoate (Pyr-Pam) showed enhanced MBD3 degradation In cells expressing high levels of [O.sup.6]-methylguamne-DNA methyltransferase (MGMT) and In GSCs, overcoming temozolomide chemoresistance. Pyr-Pam blocked recruitment of MBD3 and the repressive nudeosome remodeling and deacetylase (NuRD) complex to neurogenesisassodated gene lod and Increased acetyl-histone H3 activity and GSC differentiation. We conclude that CK1A/BTRCP/ MBD3/NuRD signaling modulates GSC activation and malignancy, and that targetingthis signaling could suppress GSC proliferation and GBM recurrence., Introduction Glioblastoma multiforme (GBM; grade IV glioma) is a heterogeneous and highly aggressive primary brain tumor with a 14.6-month survival, even after surgery, chemotherapy, and radiation therapy (1). T reatments [...]

In the volatile, uncertain, complex, and ambiguous environment (VUCA), employees can better match the organization and jobs by crafting their job perceptions, work tasks, and relationships, which is valuable to maintain organizational sustainable competitiveness and promote employees' personal growth. This study explores the influence mechanisms of job autonomy and work meaning on employees' job-crafting behaviors and the moderating effect of perceived organizational change through a survey of 318 employees in Chinese companies. The results show that job autonomy and work meaning can promote employees' job-crafting behaviors by increasing individuals' harmonious work passion. The indirect effects of job autonomy and work meaning on employee job-crafting behaviors through harmonious work passion are stronger for individuals with high perceived organizational change relative to those with low perceived organizational change. Organizations should concentrate on job redesign to improve employees' job autonomy and work meaning. A climate of change should also be created within the organization to keep employees aware of the crisis. Meanwhile, employees should actively use work resources to meet the changing needs of organizational development and promote individual career development through job-crafting behaviors. [ABSTRACT FROM AUTHOR]

Cobalt-based spinel oxides are considered potential candidates for the oxygen evolution reaction (OER) due to their abundant valence changes and promising electrochemical activity, but their low intrinsic activity hinders their practical applications. Herein, we synthesize a series of CoCeMOx (M = Zn, Ni, Ru, Er, Mg, Mn, Sn) derived from CoCeM coordination-driven self-assembled aggregates (CDSAAs) using a general ion exchange and subsequent calcination method. Interestingly, CoCeMOx exhibit different morphologies from porous nanospheres, particle-stacked nanospheres, to hollow nanospheres as the third metal element is altered. Markedly, CoCeZnOx porous nanospheres (PNs) exhibit the best OER performance. The XPS results reveal that the existence of CeO2 and Zn2+ ions significantly increased the Co2+/Co3+ ratio and the content of oxygen vacancies in Co3O4. Furthermore, Co2+ can be used as highly reactive sites to form CoOOH and the high content of oxygen vacancies can optimize the oxygen-containing intermediate adsorption energy, both of which can effectively improve the OER performance. Therefore, well-designed CoCeZnOx PNs demonstrate high OER activity with a lower overpotential (η = 333 mV) than that of commercial RuO2 (344 mV) in 10 mA cm−2, a Tafel slope of 98 mV dec−1, and a long-term durability of 45 h. This work may provide some inspiration for the design of trimetallic oxide nanomaterials. [ABSTRACT FROM AUTHOR]

Glioblastoma multiforme (GBM) heterogeneity causes a greater number of deaths than any other brain tumor, despite the availability of alkylating chemotherapy. GBM stem-like cells (GSCs) contribute to GBM complexity and chemoresistance, but it remains challenging to identify and target GSCs or factors that control their activity. Here, we identified a specific GSC subset and show that activity of these cells is positively regulated by stabilization of methyl CpG binding domain 3 (MBD3) protein. MBD3 binds to CK1A and to BTRCP E3 ubiquitin ligase, triggering MBD3 degradation, suggesting that modulating this circuit could antagonize GBM recurrence. Accordingly, xenograft mice treated with the CK1A activator pyrvinium pamoate (Pyr-Pam) showed enhanced MBD3 degradation in cells expressing high levels of O6-methylguanine-DNA methyltransferase (MGMT) and in GSCs, overcoming temozolomide chemoresistance. Pyr-Pam blocked recruitment of MBD3 and the repressive nucleosome remodeling and deacetylase (NuRD) complex to neurogenesis-associated gene loci and increased acetyl-histone H3 activity and GSC differentiation. We conclude that CK1A/BTRCP/MBD3/NuRD signaling modulates GSC activation and malignancy, and that targeting this signaling could suppress GSC proliferation and GBM recurrence. [ABSTRACT FROM AUTHOR]

Cobalt-based spinel oxides are considered potential candidates for the oxygen evolution reaction (OER) due to their abundant valence changes and promising electrochemical activity, but their low intrinsic activity hinders their practical applications. Herein, we synthesize a series of CoCeMO x (M = Zn, Ni, Ru, Er, Mg, Mn, Sn) derived from CoCeM coordination-driven self-assembled aggregates (CDSAAs) using a general ion exchange and subsequent calcination method. Interestingly, CoCeMO x exhibit different morphologies from porous nanospheres, particle-stacked nanospheres, to hollow nanospheres as the third metal element is altered. Markedly, CoCeZnO x porous nanospheres (PNs) exhibit the best OER performance. The XPS results reveal that the existence of CeO 2 and Zn 2+ ions significantly increased the Co 2+ /Co 3+ ratio and the content of oxygen vacancies in Co 3 O 4 . Furthermore, Co 2+ can be used as highly reactive sites to form CoOOH and the high content of oxygen vacancies can optimize the oxygen-containing intermediate adsorption energy, both of which can effectively improve the OER performance. Therefore, well-designed CoCeZnO x PNs demonstrate high OER activity with a lower overpotential ( η = 333 mV) than that of commercial RuO 2 (344 mV) in 10 mA cm -2 , a Tafel slope of 98 mV dec -1 , and a long-term durability of 45 h. This work may provide some inspiration for the design of trimetallic oxide nanomaterials.

The increasing demand for compact and high-performance photonic devices drives the development of optical resonators with nanoscale sizes and ultrahigh quality factors. Fabry-Pérot (FP) resonators, the most widely employed optical resonators, can support ultrahigh quality factors in the simple structure, which is particularly attractive for applications in lasers, filters, and ultrasensitive sensors. However, the construction of FP resonators with both nanoscale sizes and high quality factors has still faced challenges. Herein we demonstrate the construction of FP nanoresonators out of single Au nanodisks (NDs) and a Au film, with a WS 2 flake sandwiched in between. The atomically flat surfaces of the WS 2 flake and Au NDs benefit mirror alignment and boost the quality factor up to 76. The nanoresonators can support FP resonances with different mode orders in the visible region. The optical properties and formation mechanisms of the high-quality FP modes are systematically studied. The FP modes are further hybridized with excitons in the WS 2 flake spacer, enabling the modulation of the WS 2 indirect band gap emissions. Our study combines the advantages of plasmonic nanoparticles and FP resonators, providing a promising platform for the development of compact nanophotonic devices such as tunable nanolasers, smart sensors, and photonic-circuit elements.

Objective: To investigate the effect of inverse ratio ventilation (IRV) combined with positive end-expiratory pressure (PEEP) in infants undergoing thoracoscopic surgery with single lung ventilation (OLV) for lung cystadenomas., Methods: A total of 66 infants undergoing thoracoscopic surgery with OLV for lung cystadenomas in our hospital from February, 2018 to February, 2019 were randomized into conventional ventilation groups (group N, n =33) and inverse ventilation group (group R, n =33). Hemodynamics and respiratory parameters of the infants were recorded and arterial blood gas analysis was performed at 15 min after two lung ventilation (TLV) (T 1 ), OLV30 min (T 2 ), OLV60 min (T 3 ), and 15 min after recovery of TLV (T 4 ). Bronchoalveolar lavage fluid was collected before and after surgery to detect the expression level of advanced glycation end product receptor (RAGE)., Results: Sixty-three infants were finally included in this study. At T 2 and T 3 , Cdyn, PaO 2 and OI in group R were significantly higher ( P < 0.05) and Ppeak, PaCO 2 and PA-aO 2 were significantly lower than those in group N ( P < 0.05). There was no significant difference in HR or MAP between the two groups at T 2 and T 3 ( P > 0.05). The level of RAGE significantly increased after the surgery in both groups ( P < 0.05), and was significantly lower in R group than in N group ( P < 0.05)., Conclusions: In infants undergoing thoracoscopic surgery with OLV for pulmonary cystadenoma, appropriate IRV combined with PEEP does not affect hemodynamic stability and can increases pulmonary compliance, reduce the peak pressure, and improve oxygenation to provide pulmonary protection.