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1. CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy

Author

Gonnin, Cécile, Leemans, Michelle, Canoui-Poitrine, Florence, Lebraud, Morgane, Corneau, Aurélien, Roquebert, Louise, Caillet, Philippe, Gay, Pierre, Canovas, Johanna, Histe, Axelle, Blanc, Catherine, El-Sissy, Carine, Larbi, Anis, Poisson, Johanne, Ober, Pauline, Boudou-Rouquette, Pascaline, Natella, Pierre-André, Vallet, Hélène, Saadaoui, Besma, Layese, Richard, Tartour, Eric, Paillaud, Elena, and Granier, Clémence

Published
2024
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6. CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy.

Author

Gonnin, Cécile, Leemans, Michelle, Canoui-Poitrine, Florence, Lebraud, Morgane, Corneau, Aurélien, Roquebert, Louise, Caillet, Philippe, Gay, Pierre, Canovas, Johanna, Histe, Axelle, Blanc, Catherine, El-Sissy, Carine, Larbi, Anis, Poisson, Johanne, Ober, Pauline, Boudou-Rouquette, Pascaline, Natella, Pierre-André, Vallet, Hélène, Saadaoui, Besma, and Layese, Richard

Subjects
T-cell exhaustion, OLDER people, MEDICAL sciences, T cells, OLDER patients
Abstract

Background: Immune ageing complicates cancer treatment in older individuals. While immunotherapy targeting the PD-1/PD-L1 pathway can reinvigorate T cells, these cells tend to become senescent with age. This study investigates different CD8+ T cell subsets usually associated with senescence, in cancer patients over 70 years old who are undergoing anti-PD-1/PD-L1 immunotherapy, and examines the relationship between these senescent cells and prior chemotherapy exposure. We analyzed data from the Elderly Cancer Patient (ELCAPA) cohort, which included 35 patients enrolled between March 2018 and March 2021. Results: Flow cytometry and unsupervised analysis were employed to characterize Effector Memory CD45RA+ (EMRA) and CD8+ T cell senescence at baseline, before initiating PD-1/PD-L1 therapy. EMRA cells were found to overexpress CD57 and KLRG1 compared to overall CD8+ T cells. Chemotherapy prior to anti-PD-1/PD-L1 was associated with an increased proportion of CD57+ EMRA CD8+ T cells (p = 0.009) and its granzyme B (GRZB) subset (p = 0.007). Using a 10% cut-off to define positivity, the six-month non-response tends to be associated with the CD57+ GRZB+ EMRA positivity (p = 0.097). Other CD8+ T cell subsets (EMRA, CD57+, or KLRG1+), usually associated with senescence, showed no significant association with previous chemotherapy or response to anti-PD-1/anti-PD-L1 therapy. Conclusions: These findings underscore the impact of prior chemotherapy on expanding the pool of senescent T cells, particularly CD57+ EMRA CD8+ T and CD57+ GRZB+ EMRA CD8+ T cells, whose expansion could potentially affect the effectiveness of anti-PD-1/PD-L1 immunotherapy in elderly patients. This highlights the need for tailored approaches in this population. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Energy expenditure profiles and the risk of early limiting toxicity in older patients with cancer: The ELCAPA-25 prospective cohort survey

Author

Baudin, Aurélie, Bobin, Margot, Canovas, Johanna, Chaoui, Sabrina, Iratni, Lina, Garrigou, Sonia, Lacour, Sandrine, Mabungu, Helène, Morisset, Laure, Saadaoui, Besma, Boudou-Rouquette, Pascaline, de Moura, Alexandre, Martinez-Tapia, Claudia, Serrano, Adolfo Gonzalez, Chahwakilian, Anne, Jouinot, Anne, Ulmann, Guillaume, Orvoën, Galdric, Chambraud, Clélia, Durand, Jean-Philippe, Caillet, Philippe, Goldwasser, Francois, Paillaud, Elena, and Canouï-Poitrine, Florence

Published
2022
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12. Prediction of moderate and severe toxicities of chemotherapy in older patients with cancer: a propensity weighted analysis of ELCAPA cohort.

Author

Benderra, Marc-Antoine, Paillaud, Elena, Broussier, Amaury, Layese, Richard, Tapia, Claudia M, Mebarki, Soraya, Boudou-Rouquette, Pascale, Laurent, Marie, Piero, Monica, Rollot-Trad, Florence, Gligorov, Joseph, Caillet, Philippe, and Canoui-Poitrïne, Florence

Subjects
DRUG toxicity, RISK assessment, RESEARCH funding, DESCRIPTIVE statistics, CANCER chemotherapy, LONGITUDINAL method, ODDS ratio, STATISTICS, CONFIDENCE intervals, OLD age
Abstract

Background Currently available predictive models for chemotherapy-related toxicity are not sufficiently discriminative in older patients with cancer and do not consider moderate toxicities. The purpose of this study was to identify factors associated with moderate and severe chemotherapy toxicities in older patients with cancer. Materials and methods Patients aged 70+ recruited in the prospective ELCAPA cohort were analyzed. A total of 837 patients with data on toxicities had received chemotherapy without other systemic treatment and were included between 2015 and 2022. To adjust for any imbalances in the distribution of covariates between patients receiving single-agent chemotherapy vs combination chemotherapy, we applied overlap weighting (a propensity-score-based technique). We used multinomial logistic regression. Results Median (interquartile range) age was 81 (77-84). Forty-one percent experienced moderate toxicity, and 33% experienced severe toxicity. Hematologic toxicities accounted for 53% of severe toxicities and 66% of moderate toxicities. Age <80 years, cancer type, metastatic status, Eastern Cooperative Oncology Group performance status (ECOG-PS) >1, no cognitive impairment were associated with combination chemotherapy decision. In a univariate analysis with overlap weighting, no factors were associated with moderate toxicity. Hemoglobin < 10 g/dL and a CIRS-G score >12 were associated with severe toxicity. In a multivariate analysis, only hemoglobin < 10 g/dL was independently associated with severe toxicity, adjusted OR 2.96 (95% CI, 1.20-7.29). Conclusion By addressing indication bias for combination chemotherapy decision, only anemia and not cancer type, combination chemotherapy was predicting for severe chemotherapy-related toxicity in older patients with cancer. We did not find any predictors of moderate chemotherapy-related toxicity. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Predicting frailty domain impairments and mortality with the Hospital Frailty Risk Score among older adults with cancer: the ELCAPA-EDS cohort study.

Author

Jean, Charline, Paillaud, Elena, Boudou-Rouquette, Pascaline, Martinez-Tapia, Claudia, Pamoukdjian, Frédéric, Hagège, Meoïn, Bréant, Stéphane, Hassen-Khodja, Claire, Natella, Pierre-André, Cudennec, Tristan, Laurent, Marie, Caillet, Philippe, Canouï-Poitrine, Florence, and Audureau, Etienne

Subjects
RISK assessment, PREDICTIVE tests, ELDER care, NUTRITION disorders, ACADEMIC medical centers, URINARY incontinence, FRAIL elderly, RESEARCH methodology evaluation, BENCHMARKING (Management), LOGISTIC regression analysis, CANCER patients, HOSPITAL mortality, RETROSPECTIVE studies, POLYPHARMACY, AFFECTIVE disorders, DESCRIPTIVE statistics, RESEARCH methodology, MEDICAL records, ACQUISITION of data, GERIATRIC assessment, COGNITION disorders, MEDICAL screening, HOSPITAL care of older people, LENGTH of stay in hospitals, PREDICTIVE validity, CRITICAL care medicine, PROPORTIONAL hazards models, COMORBIDITY, DISCRIMINANT analysis, OLD age
Abstract

Background Automated frailty screening tools like the Hospital Frailty Risk Score (HFRS) are primarily validated for care consumption outcomes. We assessed the predictive ability of the HFRS regarding care consumption outcomes, frailty domain impairments and mortality among older adults with cancer, using the Geriatric 8 (G8) screening tool as a clinical benchmark. Methods This retrospective, linkage-based study included patients aged ≥70 years with solid tumor, enrolled in the Elderly Cancer Patients (ELCAPA) multicentre cohort study (2016–2020) and hospitalized in acute care within the Greater Paris University Hospitals. HFRS scores, which encompass hospital-acquired problems and frailty-related syndromes, were calculated using data from the index admission and the preceding 6 months. A multidomain geriatric assessment (GA), including cognition, nutrition, mood, functional status, mobility, comorbidities, polypharmacy, incontinence, and social environment, was conducted at ELCAPA inclusion, with computation of the G8 score. Logistic and Cox regressions measured associations between the G8, HFRS, altered GA domains, length of stay exceeding 10 days, 30-day readmission, and mortality. Results Among 587 patients included (median age 82 years, metastatic cancer 47.0%), 237 (40.4%) were at increased frailty risk by the HFRS (HFRS>5) and 261 (47.5%) by the G8 (G8≤10). Both HFRS and G8 were significantly associated with cognitive and functional impairments, incontinence, comorbidities, prolonged length of stay, and 30-day mortality. The G8 was associated with polypharmacy, nutritional and mood impairment. Discussion Although showing significant associations with short-term care consumption, the HFRS could not identify polypharmacy, nutritional, mood and social environment impairments and showed low discriminatory ability across all GA domains. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Hospital Care Trajectories of Older Adults with Cancer and the Associated Clinical Profiles: linking a French Prospective Cohort Study and a Clinical Data Warehouse

Author

Jean, Charline, primary, Paillaud, Elena, additional, Boudou-Rouquette, Pascaline, additional, Martinez-Tapia, Claudia, additional, Pamoukdjian, Frédéric, additional, Hagège, Meoïn, additional, Bréant, Stéphane, additional, Hassen-Khodja, Claire, additional, Natella, Pierre-André, additional, Cudennec, Tristan, additional, Laurent, Marie, additional, Caillet, Philippe, additional, Audureau, Etienne, additional, and Canouï-Poitrine, Florence, additional

Published
2024
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20. Alterations in comprehensive geriatric assessment decrease survival of elderly patients with cancer

Author

Jeannin, Gaelle, Patrick, Merle, Nehme, Hélène, Leroy, Virginie, De Mones Del Pujol, Erwan, Ravaud, Alain, Maget, Brigitte, Jovenin, Nicolas, Feugier, Pierre, Bologna, Serge, Comte, Brigitte, Falandry, Claire, Mailliez, Audrey, Villers, Arnauld, Rose, Christian, Bonnal, Jean-Louis, Minard, Aurélien, Gisselbrecht, Mathilde, Ladoire, Sylvain, Quipourt, Valérie, Lavau-Denes, Sandrine, Le Brun-Ly, Valérie, Thiberville, Luc, Rigal, Olivier, Lagrange, Jean Léon, Caillet, Philippe, Rousseau, Frédérique, De Decker, Laure, Bourbouloux, Emmanuelle, Carola, Elisabeth, Woerth, Florence, Brain, Etienne, Ribiere, Ludmilla, Stefani, Laeticia, Debray, Matthieu, Thieblemont, Catherine, Gisselbrecht, Christian, Balardy, Laurent, Mourey, Loic, Chaibi, Pascal, Frasca, M., Soubeyran, P., Bellera, C., Rainfray, M., Leffondre, K., and Mathoulin-Pélissier, S.

Published
2018
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21. Cancer mortality and competing causes of death in older adults with cancer: A prospective, multicentre cohort study (ELCAPA‐19)

Author

Assouan, Déborah, primary, Paillaud, Elena, additional, Caillet, Philippe, additional, Broussier, Amaury, additional, Kempf, Emmanuelle, additional, Frelaut, Maxime, additional, Brain, Etienne, additional, Lorisson, Emmanuelle, additional, Chambraud, Clelia, additional, Bastuji‐Garin, Sylvie, additional, Hanon, Olivier, additional, Canouï‐Poitrine, Florence, additional, Laurent, Marie, additional, and Martinez‐Tapia, Claudia, additional

Published
2023
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26. Geriatric assessment and quality of life for 2 years in older patients with head and neck cancer.

Author

Lafont, Charlotte, Paillaud, Elena, Bertolus, Chloe, Baron, Melany, Caillet, Philippe, Bouvard, Eric, Laurent, Marie, Salvan, Didier, Chaumette, Laurence, Decker, Laure de, Piot, Benoit, Barry, Beatrix, Raynaud-Simon, Agathe, Sauvaget, Elisabeth, Minard, Aurélien, Anota, Amélie, Panjo, Henri, Brugel, Lydia, and Canouï-Poitrine, Florence

Subjects
HEAD & neck cancer, OLDER patients, GERIATRIC assessment, QUALITY of life, FUNCTIONAL status
Abstract

Due to the location and toxicity of treatments, head and neck cancer (HNC) has a major impact on quality of life (QoL). Objective: to assess the effects of geriatric-assessment (GA)-driven interventions on QoL over 2 years in older adults with HNC. EGeSOR was a randomized study of HNC patients aged ≥65, receiving a pretreatment GA, a geriatric intervention and follow-up (intervention) or standard of care (control). The primary endpoint was QoL score using the European Organisation for Research and Treatment of Cancer's (EORTC QLQ-C30) and HNC (QLQ-HN35) QoL questionnaires over 24 months. In total, 475 patients were included (median age: 75.3; women: 31%; oral cancer: 44%). QoL scores improved over 24 months with various trajectories, without significant differences between the groups. A total of 74% of patients (interventional group) did not receive the complete intervention. Cancer characteristics, functional status, and risk of frailty were associated with change in the Global Health Status QoL score. There is a need to develop an alternative model of implementation such as patient-centered health-care pathways. Trial registration NCT02025062. [ABSTRACT FROM AUTHOR]

Published
2024
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28. External Validity of Two Scores for Predicting the Risk of Chemotherapy Toxicity Among Older Patients With Solid Tumors: Results From the ELCAPA Prospective Cohort

Author

Frelaut, Maxime, primary, Paillaud, Elena, additional, Beinse, Guillaume, additional, Scain, Anne-Laure, additional, Culine, Stéphane, additional, Tournigand, Christophe, additional, Poisson, Johanne, additional, Bastuji-Garin, Sylvie, additional, Canoui-Poitrine, Florence, additional, and Caillet, Philippe, additional

Published
2023
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29. A Two-Step Frailty Assessment Strategy in Older Patients With Solid Tumors: A Decision Curve Analysis

Author

González Serrano, Adolfo, primary, Laurent, Marie, additional, Barnay, Thomas, additional, Martínez-Tapia, Claudia, additional, Audureau, Etienne, additional, Boudou-Rouquette, Pascaline, additional, Aparicio, Thomas, additional, Rollot-Trad, Florence, additional, Soubeyran, Pierre, additional, Bellera, Carine, additional, Caillet, Philippe, additional, Paillaud, Elena, additional, and Canouï-Poitrine, Florence, additional

Published
2023
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35. Chronological Age and Risk of Chemotherapy Nonfeasibility: A Real-Life Cohort Study of 153 Stage II or III Colorectal Cancer Patients Given Adjuvant-modified FOLFOX6

Author

Laurent, Marie, Des Guetz, Gaétan, Bastuji-Garin, Sylvie, Culine, Stéphane, Caillet, Philippe, Aparicio, Thomas, Audureau, Etienne, Carvahlo-Verlinde, Muriel, Reinald, Nicoleta, Tournigand, Christophe, Landre, Thierry, LeThuaut, Aurélie, Paillaud, Elena, and Canouï-Poitrine, Florence

Published
2018
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36. Effectiveness of Geriatric Assessment-Driven Interventions on Survival and Functional and Nutritional Status in Older Patients with Head and Neck Cancer: A Randomized Controlled Trial (EGeSOR)

Author

Paillaud, Elena, primary, Brugel, Lydia, additional, Bertolus, Chloe, additional, Baron, Melany, additional, Bequignon, Emilie, additional, Caillet, Philippe, additional, Schouman, Thomas, additional, Lacau Saint Guily, Jean, additional, Périé, Sophie, additional, Bouvard, Eric, additional, Laurent, Marie, additional, Salvan, Didier, additional, Chaumette, Laurence, additional, de Decker, Laure, additional, Piot, Benoit, additional, Barry, Beatrix, additional, Raynaud-Simon, Agathe, additional, Sauvaget, Elisabeth, additional, Bach, Christine, additional, Bizard, Antoine, additional, Bounar, Abderrahmane, additional, Minard, Aurelien, additional, Aziz, Bechara, additional, Chevalier, Eric, additional, Chevalier, Dominique, additional, Gaxatte, Cedric, additional, Malard, Olivier, additional, Liuu, Evelyne, additional, Lacour, Sandrine, additional, Gregoire, Laetitia, additional, Lafont, Charlotte, additional, and Canouï-Poitrine, Florence, additional

Published
2022
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37. A decision curve analysis of the clinical usefulness of a two-step frailty assessment strategy in older patients with prostate, breast, colorectal, or lung cancer.

Author

Gonzalez Serrano, Adolfo, primary, Laurent, Marie, additional, Barnay, Thomas, additional, Martinez-Tapia, Claudia, additional, Audureau, Etienne, additional, Boudou-Rouquette, Pascaline, additional, Aparicio, Thomas, additional, Rollot-Trad, Florence, additional, Soubeyran, Pierre, additional, Bellera, Carine A., additional, Paillaud, Elena, additional, Caillet, Philippe, additional, and Canoui-Poitrine, Florence, additional

Published
2022
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38. Energy expenditure profiles and the risk of early limiting toxicity in older patients with cancer: The ELCAPA-25 prospective cohort survey

Author

Boudou-Rouquette, Pascaline, primary, de Moura, Alexandre, additional, Martinez-Tapia, Claudia, additional, Serrano, Adolfo Gonzalez, additional, Chahwakilian, Anne, additional, Jouinot, Anne, additional, Ulmann, Guillaume, additional, Orvoën, Galdric, additional, Chambraud, Clélia, additional, Durand, Jean-Philippe, additional, Caillet, Philippe, additional, Goldwasser, Francois, additional, Paillaud, Elena, additional, Canouï-Poitrine, Florence, additional, Baudin, Aurélie, additional, Bobin, Margot, additional, Canovas, Johanna, additional, Chaoui, Sabrina, additional, Iratni, Lina, additional, Garrigou, Sonia, additional, Lacour, Sandrine, additional, Mabungu, Helène, additional, Morisset, Laure, additional, and Saadaoui, Besma, additional

Published
2022
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41. Liste des auteurs

Author

Aquino, Jean-Pierre, primary, Cudennec, Tristan, additional, Barthélémy, Lucette, additional, Andrieu, Sandrine, additional, Ankri, Joël, additional, Arrouy, Laurence, additional, Aubert, Lucie, additional, Baranes, Joseph John, additional, Barret, Béatrice, additional, Baudry, Élodie, additional, Bayle, Catherine, additional, Beaune, Sébastien, additional, Beguin, Anne-Marie, additional, Beguin, Mathilde, additional, Bérard, Alain, additional, Blanckaert, Antonin, additional, Zamponi, Dominique Bonnet, additional, Bouaziz, Walid, additional, Bouccara, Didier, additional, Bouchara, Julie, additional, Brieu, Marie-Anne, additional, Bula, Christophe, additional, Caillet, Philippe, additional, Cambon, Laurent, additional, Caron-Thibault, Gauthier, additional, Carrère, Barbara, additional, Chapon, Pierre-Marie, additional, Charras, Kevin, additional, Chassagne, Philippe, additional, Chevallier, Anita, additional, Chevrier, Roland, additional, Coconnier, Andrée, additional, Cohen, Marc, additional, Curatolo, Niccolo, additional, Daire, Rodolphe, additional, De Malherbe, Adèle, additional, de Rotrou, Jocelyne, additional, Dejardin, Philippe, additional, Demory, Mathilde, additional, Denis, Bertrand, additional, Derville, Sandrine, additional, Desana, Marie-Odile, additional, Driessen, Élodie, additional, Duportet, Bernard, additional, Dupré-Lévêque, Delphine, additional, Dupuy, Charlotte, additional, Durpoix, Catherine, additional, Eclancher, Sandra, additional, Forestier, Begum Errol, additional, Farag, Laurent, additional, Fauchard, Gwenaelle, additional, Faucher, Nathalie, additional, Feteanu, Dorin, additional, Forestier, Romain, additional, Forette, Françoise, additional, Françon, Alain, additional, Fuchs, Marie-Françoise, additional, Fulop, Tamas, additional, Gavazzi, Gaëtan, additional, Geoffroy, Marie, additional, Gervais, Xavier, additional, Giron, Paule, additional, Godart, Marie-Christine, additional, Guérin, Oliver, additional, Guillet, Philippe, additional, Guitton, Claire, additional, Gzil, Fabrice, additional, Halimi, Didier, additional, Harboun, Marc, additional, Hautin, Pascale, additional, Hervy, Bernard, additional, Houles, Mathieu, additional, Hubert, Sidonie, additional, Hugonot-Diener, Laurence, additional, Hugues, Julie, additional, Hugues, Philippe, additional, Jacquin-Mourain, Nicole, additional, Jeandel, Claude, additional, Jothy, Anne-Catherine, additional, Kaltenbach, Georges, additional, Lapierre, Vincent, additional, Lefebvre, Pierre-Olivier, additional, Legrain, Sylvie, additional, Le Guen, Julien, additional, Lemaire, Aurélie, additional, Lesure, Christine, additional, Madjlessi, Arach, additional, Malaquin-Pavan, Évelyne, additional, Manciaux, Marie-Agnès, additional, Martin, Marie-Laure, additional, Maubourguet, Nathalie, additional, Menecier, Pascal, additional, Mohebi, Alexis, additional, Morvillers, Jean-Manuel, additional, Motte, Valérie, additional, Moulias, Sophie, additional, Garcia, Araceli Muela, additional, Muller, Florence, additional, Noaillon, Mathilde, additional, Nogues, Michel, additional, Nouvel, Fabrice, additional, Paccard, Delphine, additional, Paillaud, Éléna, additional, Péan, Hélène, additional, Pedepeyrau, Cécilia, additional, Pigné, Étienne, additional, Pin, Stéphanie, additional, Platel, Hervé, additional, Prate, Frédéric, additional, Rapagnani, Giuliana, additional, Raynaud-Simon, Agathe, additional, Reguer, Daniel, additional, Renkes, Jacqueline, additional, Reznikoff, Valérie, additional, Robert, Philippe, additional, Robine, Jean-Marie, additional, Rogez, Élisabeth, additional, Rolland, Yves, additional, Rothan-Tondeur, Monique, additional, Sacco, Guillaume, additional, Saint-Gaudens, Pascale, additional, Salord, Jean-Claude, additional, Schmitt, Elisé, additional, Sifaoui, Brigitte, additional, Somme, Dominique, additional, Sophie, Lartigue, additional, Suzanne, Olivier, additional, Teillet, Laurent, additional, Teixeira, Antonio, additional, Thillard, Anne Lyse, additional, Tifratène, Karim, additional, Trotet, Sarah, additional, Vellas, Bruno, additional, Verny, Christiane, additional, Verny, Marc, additional, Viatour, Géraldine, additional, Vilaine, Ève, additional, Villez, Marion, additional, Vincent, Hélène, additional, and Vogel, Thomas, additional

Published
2016
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43. Abstract P1-18-04: Feasibility of palbociclib in women aged 70 and older with resistant and/or pretreated advanced breast cancer in the PALOMAGE study

Author

Brain, Etienne, primary, Pulido, Marina, additional, Paillaud, Elena, additional, Grosjean, Jessica, additional, Mina, William, additional, Caillet, Philippe, additional, Tassy, Louis, additional, Soubeyran, Pierre, additional, Bouteiller, Fanny, additional, Rifi, Nada, additional, Vauthier, Jean-Michel, additional, Falandry, Claire, additional, and Carola, Elisabeth, additional

Published
2022
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44. Targeted Therapy for Older Patients with Non-Small Cell Lung Cancer: Systematic Review and Guidelines from the French Society of Geriatric Oncology (SoFOG) and the French-Language Society of Pulmonology (SPLF)/French-Language Oncology Group (GOLF)

Author

Greillier, Laurent, primary, Gauvrit, Manon, additional, Paillaud, Elena, additional, Girard, Nicolas, additional, Montégut, Coline, additional, Boulahssass, Rabia, additional, Wislez, Marie, additional, Pamoukdjian, Frédéric, additional, Corre, Romain, additional, Cabart, Mathilde, additional, Caillet, Philippe, additional, Belaroussi, Yaniss, additional, Frasca, Matthieu, additional, Noize, Pernelle, additional, Wang, Pascal, additional, Mebarki, Soraya, additional, Mathoulin-Pelissier, Simone, additional, and Couderc, Anne-Laure, additional

Published
2022
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45. Predicting Frailty and Geriatric Interventions in Older Cancer Patients: Performance of Two Screening Tools for Seven Frailty Definitions—ELCAPA Cohort

Author

Martinez-Tapia, Claudia, primary, Laurent, Marie, additional, Paillaud, Elena, additional, Caillet, Philippe, additional, Ferrat, Emilie, additional, Lagrange, Jean-Léon, additional, Rwabihama, Jean-Paul, additional, Allain, Mylène, additional, Chahwakilian, Anne, additional, Boudou-Rouquette, Pascaline, additional, Bastuji-Garin, Sylvie, additional, and Audureau, Etienne, additional

Published
2022
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46. Prognostic Value of Routinely Measured Inflammatory Biomarkers in Older Cancer Patients: Pooled Analysis of Three Cohorts

Author

Oubaya, Nadia, primary, Soubeyran, Pierre, additional, Reinald, Nicoleta, additional, Fonck, Marianne, additional, Allain, Mylène, additional, Zebachi, Sonia, additional, Heitz, Damien, additional, Laurent, Marie, additional, Delattre, Cécile, additional, Caillet, Philippe, additional, Dauba, Jérôme, additional, Bastuji-Garin, Sylvie, additional, Albrand, Gilles, additional, Bringuier, Michael, additional, Rainfray, Muriel, additional, Brain, Etienne, additional, Grellety, Thomas, additional, Paillaud, Elena, additional, Mathoulin-Pélissier, Simone, additional, Bellera, Carine, additional, and Canouï-Poitrine, Florence, additional

Published
2021
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48. Complications and Discharge after Radical Cystectomy for Older Patients with Muscle-Invasive Bladder Cancer: The ELCAPA-27 Cohort Study

Author

Geiss, Romain, primary, Sebaste, Lucrezia, additional, Valter, Rémi, additional, Poisson, Johanne, additional, Mebarki, Soraya, additional, Conti, Catherine, additional, Vordos, Dimitri, additional, Bringuier, Michael, additional, Méjean, Arnaud, additional, Mongiat-Artus, Pierre, additional, Cudennec, Tristan, additional, Canoui-Poitrine, Florence, additional, Caillet, Philippe, additional, and Paillaud, Elena, additional

Published
2021
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49. PALOMAGE, a French real-world cohort of elderly women beyond age 70 with advanced breast cancer receiving palbociclib: Baseline characteristics and safety evaluation.

Author

Caillet, Philippe, primary, Pulido, Marina, additional, Brain, Etienne, additional, Falandry, Claire, additional, Desmoulins, Isabelle, additional, Ghebriou, Djamel, additional, Soubeyran, Pierre-Louis, additional, Paillaud, Elena, additional, Rifi, Nada, additional, Vauthier, Jean Michel, additional, Tassy, Louis, additional, and Carola, Elisabeth, additional

Published
2021
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50. Relations between undernutrition and nosocomial infections in elderly patients

Author

Paillaud, Elena, Herbaud, Stephane, Caillet, Philippe, Lejonc, Jean-Louis, Campillo, Bernard, and Bories, Phuong-Nhi

Subjects
Cross infection -- Risk factors, Nosocomial infections -- Risk factors, Aged -- Care and treatment, Aged -- Health aspects, Malnutrition -- Risk factors, Health, Psychology and mental health, Seniors, Social sciences
Published
2005

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