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10. FRIPON: a worldwide network to track incoming meteoroids

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Marsset, Michaël, Brož, Miroslav, Castillo-Rogez, Julie, Hanuš, Josef, Viikinkoski, Matti, Ševeček, Pavel, Marchis, Franck, Podlewska-Gaca, Edyta, Asphaug, Erik, Bartczak, Przemyslaw, Berthier, Jérôme, Cipriani, Fabrice, Dudziński, Grzegorz, Dumas, Christophe, Ďurech, Josef, Ferrais, Marin, Fétick, Romain, Fusco, Thierry, Kaasalainen, Mikko, Kryszczynska, Agnieszka, Lamy, Philippe, Le Coroller, Hervé, Marciniak, Anna, Michalowski, Tadeusz, Michel, Patrick, Richardson, Derek, Santana-Ros, Toni, Vachier, Frédéric, Vigan, Arthur, Witasse, Olivier, Yang, Bin, Colas, François, Zanda, B., Bouley, S., Jeanne, S., Malgoyre, A., Birlan, Mirel, Blanpain, C., Gattacceca, J., Jorda, Laurent, Lecubin, J., Marmo, C., Rault, J., Vaubaillon, J., Vernazza, Pierre, Yohia, C., Gardiol, D., Nedelcu, A., Poppe, B., Rowe, J., Forcier, M., Trigo-Rodriguez, J., Lamy, H., Behrend, R., Ferrière, L., Barghini, D., Buzzoni, A., Carbognani, A., Di Carlo, M., Di Martino, M., Knapic, C., Londero, E., Pratesi, G., Rasetti, S., Riva, W., Stirpe, G., Valsecchi, G., Volpicelli, C., Zorba, S., Coward, D., Drolshagen, E., Drolshagen, G., Hernandez, O., Jehin, Emmanuel, Jobin, M., King, A., Nitschelm, C., Ott, T., Sanchez-Lavega, A., Toni, A., Abraham, P., Affaticati, F., Albani, M., Andreis, A., Andrieu, T., Anghel, S., Antaluca, E., Antier, K., Appéré, T., Armand, A., Ascione, G., Audureau, Y., Auxepaules, G., Avoscan, T., Baba Aissa, D., Bacci, P., Bǎdescu, O., Baldini, R., Baldo, R., Balestrero, A., Baratoux, D., Barbotin, E., Bardy, M., Basso, S., Bautista, O., Bayle, L., Beck, P., Bellitto, R., Belluso, R., Benna, C., Benammi, M., Beneteau, E., Benkhaldoun, Z., Bergamini, P., Bernardi, F., Bertaina, M., Bessin, P., Betti, L., Bettonvil, F., Bihel, D., Birnbaum, C., Blagoi, O., Blouri, E., Boacă, I., Boatǎ, R., Bobiet, B., Bonino, R., Boros, K., Bouchet, E., Borgeot, V., Bouchez, E., Boust, D., Boudon, V., Bouman, T., Bourget, P., Brandenburg, S., Bramond, Ph., Braun, E., Bussi, A., Cacault, P., Caillier, B., Calegaro, A., Camargo, J., Caminade, S., Campana, A., Campbell-Burns, P., Canal-Domingo, R., Carell, O., Carreau, S., Cascone, E., Cattaneo, C., Cauhape, P., Cavier, P., Celestin, S., Cellino, A., Champenois, M., Chennaoui Aoudjehane, H., Chevrier, S., Cholvy, P., Chomier, L., Christou, A., Cricchio, D., Coadou, P., Cocaign, J., Cochard, F., Cointin, S., Colombi, E., Colque Saavedra, J., Corp, L., Costa, M., Costard, F., COTTIER, M., Cournoyer, P., Coustal, E., Cremonese, G., Cristea, O., Cuzon, J., D’Agostino, G., Daiffallah, K., Dǎnescu, C., Dardon, A., Dasse, T., Davadan, C., Debs, V., Defaix, J., Deleflie, F., D’Elia, M., De Luca, P., De Maria, P., Deverchère, P., Devillepoix, H., Dias, A., Di Dato, A., Di Luca, R., Dominici, F., Drouard, Alexis, Dumont, J., Dupouy, P., Duvignac, L., Egal, A., Erasmus, N., Esseiva, N., Ebel, A., Eisengarten, B., Federici, F., Feral, S., Ferrant, G., Ferreol, E., Finitzer, P., Foucault, A., Francois, P., Frîncu, M., Froger, J., Gaborit, F., Gagliarducci, V., Galard, J., Gardavot, A., Garmier, M., Garnung, M., Gautier, B., Gendre, B., Gerard, D., Gerardi, A., Godet, J., Grandchamps, A., Grouiez, B., Groult, S., Guidetti, D., Giuli, G., Hello, Y., Henry, X., Herbreteau, G., Herpin, M., Hewins, P., Hillairet, J., Horak, J., Hueso, R., Huet, E., Huet, S., Hyaumé, F., Interrante, G., Isselin, Y., Jeangeorges, Y., Janeux, P., Jeanneret, P., Jobse, K., Jouin, S., Jouvard, J., Joy, K., Julien, J., Kacerek, R., Kaire, M., Kempf, M., Koschny, D., Krier, C., Kwon, M., Lacassagne, L., Lachat, D., Lagain, A., Laisné, E., Lanchares, V., Laskar, J., Lazzarin, M., Leblanc, M., Lebreton, J., Lecomte, J., Le Dû, P., LELONG, F., Lera, S., Leoni, J., Le-Pichon, A., Le-Poupon, P., Leroy, A., Leto, G., Levansuu, A., Lewin, E., Lienard, A., Licchelli, D., LOCATELLI, H., Loehle, S., Loizeau, D., Luciani, L., Maignan, M., Manca, F., Mancuso, S., Mandon, E., Mangold, N., Mannucci, F., Maquet, L., Marant, D., Marchal, Y., Marin, J., Martin-Brisset, J., Martin, D., Mathieu, D., Maury, A., Mespoulet, N., Meyer, F., Meyer, J., Meza, E., Moggi Cecchi, V., Moiroud, J., Millan, M., Montesarchio, M., Misiano, A., Molinari, E., Molau, S., Monari, J., Monflier, B., Monkos, A., Montemaggi, M., Monti, G., Moreau, R., Morin, J., Mourgues, R., Mousis, O., Nablanc, C., Nastasi, A., Niacşu, L., Notez, P., Ory, M., Pace, E., Paganelli, M., Pagola, A., Pajuelo, M., Palacián, J., Pallier, G., Paraschiv, P., Pardini, R., Pavone, M., Pavy, G., Payen, G., Pegoraro, A., Peña-Asensio, E., Perez, L., Pérez-Hoyos, S., Perlerin, V., Peyrot, A., Peth, F., Pic, V., Pietronave, S., Pilger, C., Piquel, M., Pisanu, T., Poppe, M., Portois, L., Prezeau, J., Pugno, N., Quantin, C., Quitté, G., Rambaux, Nicolas, Ravier, E., Repetti, U., Ribas, S., Richard, C., Richard, D., RIGONI, M., Rivet, J., Rizzi, N., Rochain, S., Rojas, J.F., Romeo, M., Rotaru, M., Rotger, M., Rougier, P., Rousselot, P., Rousset, J., Rousseu, D., Rubiera, O., Rudawska, R., Rudelle, J., Ruguet, J.P., Russo, P., Sales, S., Sauzereau, O., Salvati, F., Schieffer, M., Schreiner, D., Scribano, Y., Selvestrel, D., Serra, R., Shengold, L., Shuttleworth, A., Smareglia, R., Sohy, S., Soldi, M., Stanga, R., Steinhausser, A., Strafella, F., Sylla Mbaye, S., Smedley, A., Tagger, M., Tanga, Paolo, Taricco, C., Teng, J., Tercu, J., Thizy, O., Thomas, J., Tombelli, M., Trangosi, R., Tregon, B., Trivero, P., Tukkers, A., Turcu, V., Umbriaco, G., Unda-Sanzana, E., Vairetti, R., Valenzuela, M., Valente, G., Varennes, G., Vauclair, S., Vergne, J., Verlinden, M., Vidal-Alaiz, M., Vieira-Martins, R., Viel, A., Vîntdevarǎ, D., Vinogradoff, V., Volpini, P., Wendling, M., Wilhelm, P., Wohlgemuth, K., Yanguas, P., Zagarella, R., Zollo, A., l'Observatoire de Paris, Muséum national d'Histoire naturelle (France), Université Paris-Saclay, OSU Institut Pythéas, Istituto Nazionale di Astrofisica, Fondazione Cassa di Risparmio di Torino, Fondazione De Mari Savona, Diputación Foral de Bizkaia, Ministry of Research and Innovation (Romania), Museu de Astronomia e Ciências Afins (Brazil), Labex ESEP, Sorbonne Université, Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa. InaMat - Institute for Advanced Materials, Universidad Pública de Navarra. Departamento de Estadística, Informática y Matemáticas, Nafarroako Unibertsitate Publikoa. Estatistika, Informatika eta Matematika Saila, Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Pythéas (OSU PYTHEAS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA (UMR_8112)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Unité Scientifique de la Station de Nançay (USN), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), Laboratoire de paléontologie, évolution, paléoécosystèmes, paléoprimatologie (PALEVOPRIM ), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL), Diagnostic des Plasmas Hors Equilibres (DPHE), Institut national universitaire Champollion [Albi] (INUC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Laboratoire de Physique et Chimie de l'Environnement et de l'Espace (LPC2E), Observatoire des Sciences de l'Univers en région Centre (OSUC), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Architecture et Logiciels pour Systèmes Embarqués sur Puce (ALSOC), LIP6, Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres (LERMA), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Planétologie et Géosciences - Le Mans (LPG - Le Mans), Laboratoire de Planétologie et Géosciences [UMR_C 6112] (LPG), Université d'Angers (UA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Université d'Angers (UA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB), Université de Technologie de Belfort-Montbeliard (UTBM)-Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT), Lumière, nanomatériaux et nanotechnologies (L2n), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Morphodynamique Continentale et Côtière (M2C), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Géosciences Paris Saclay (GEOPS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Colas, F., Zanda, B., Bouley, S., Jeanne, S., Malgoyre, A., Birlan, M., Blanpain, C., Gattacceca, J., Jorda, L., Lecubin, J., Marmo, C., Rault, J. L., Vaubaillon, J., Vernazza, P., Yohia, C., Gardiol, D., Nedelcu, A., Poppe, B., Rowe, J., Forcier, M., Koschny, D., Trigo-Rodriguez, J. M., Lamy, H., Behrend, R., Ferriere, L., Barghini, D., Buzzoni, A., Carbognani, A., Di Carlo, M., Di Martino, M., Knapic, C., Londero, E., Pratesi, G., Rasetti, S., Riva, W., Stirpe, G. M., Valsecchi, G. B., Volpicelli, C. A., Zorba, S., Coward, D., Drolshagen, E., Drolshagen, G., Hernandez, O., Jehin, E., Jobin, M., King, A., Nitschelm, C., Ott, T., Sanchez-Lavega, A., Toni, A., Abraham, P., Affaticati, F., Albani, M., Andreis, A., Andrieu, T., Anghel, S., Antaluca, E., Antier, K., Appere, T., Armand, A., Ascione, G., Audureau, Y., Auxepaules, G., Avoscan, T., Baba Aissa, D., Bacci, P., Badescu, O., Baldini, R., Baldo, R., Balestrero, A., Baratoux, D., Barbotin, E., Bardy, M., Basso, S., Bautista, O., Bayle, L. D., Beck, P., Bellitto, R., Belluso, R., Benna, C., Benammi, M., Beneteau, E., Benkhaldoun, Z., Bergamini, P., Bernardi, F., Bertaina, M. E., Bessin, P., Betti, L., Bettonvil, F., Bihel, D., Birnbaum, C., Blagoi, O., Blouri, E., Boaca, I., Boata, R., Bobiet, B., Bonino, R., Boros, K., Bouchet, E., Borgeot, V., Bouchez, E., Boust, D., Boudon, V., Bouman, T., Bourget, P., Brandenburg, S., Bramond, P., Braun, E., Bussi, A., Cacault, P., Caillier, B., Calegaro, A., Camargo, J., Caminade, S., Campana, A. P. C., Campbell-Burns, P., Canal-Domingo, R., Carell, O., Carreau, S., Cascone, E., Cattaneo, C., Cauhape, P., Cavier, P., Celestin, S., Cellino, A., Champenois, M., Chennaoui Aoudjehane, H., Chevrier, S., Cholvy, P., Chomier, L., Christou, A., Cricchio, D., Coadou, P., Cocaign, J. Y., Cochard, F., Cointin, S., Colombi, E., Colque Saavedra, J. P., Corp, L., Costa, M., Costard, F., Cottier, M., Cournoyer, P., Coustal, E., Cremonese, G., Cristea, O., Cuzon, J. C., D'Agostino, G., Daiffallah, K., Danescu, C., Dardon, A., Dasse, T., Davadan, C., Debs, V., Defaix, J. P., Deleflie, F., D'Elia, M., De Luca, P., De Maria, P., Deverchere, P., Devillepoix, H., Dias, A., Di Dato, A., Di Luca, R., Dominici, F. M., Drouard, A., Dumont, J. L., Dupouy, P., Duvignac, L., Egal, A., Erasmus, N., Esseiva, N., Ebel, A., Eisengarten, B., Federici, F., Feral, S., Ferrant, G., Ferreol, E., Finitzer, P., Foucault, A., Francois, P., Frincu, M., Froger, J. L., Gaborit, F., Gagliarducci, V., Galard, J., Gardavot, A., Garmier, M., Garnung, M., Gautier, B., Gendre, B., Gerard, D., Gerardi, A., Godet, J. P., Grandchamps, A., Grouiez, B., Groult, S., Guidetti, D., Giuli, G., Hello, Y., Henry, X., Herbreteau, G., Herpin, M., Hewins, P., Hillairet, J. J., Horak, J., Hueso, R., Huet, E., Huet, S., Hyaume, F., Interrante, G., Isselin, Y., Jeangeorges, Y., Janeux, P., Jeanneret, P., Jobse, K., Jouin, S., Jouvard, J. M., Joy, K., Julien, J. F., Kacerek, R., Kaire, M., Kempf, M., Krier, C., Kwon, M. K., Lacassagne, L., Lachat, D., Lagain, A., Laisne, E., Lanchares, V., Laskar, J., Lazzarin, M., Leblanc, M., Lebreton, J. P., Lecomte, J., Le Du, P., Lelong, F., Lera, S., Leoni, J. F., Le-Pichon, A., Le-Poupon, P., Leroy, A., Leto, G., Levansuu, A., Lewin, E., Lienard, A., Licchelli, D., Locatelli, H., Loehle, S., Loizeau, D., Luciani, L., Maignan, M., Manca, F., Mancuso, S., Mandon, E., Mangold, N., Mannucci, F., Maquet, L., Marant, D., Marchal, Y., Marin, J. L., Martin-Brisset, J. C., Martin, D., Mathieu, D., Maury, A., Mespoulet, N., Meyer, F., Meyer, J. Y., Meza, E., Moggi Cecchi, V., Moiroud, J. J., Millan, M., Montesarchio, M., Misiano, A., Molinari, E., Molau, S., Monari, J., Monflier, B., Monkos, A., Montemaggi, M., Monti, G., Moreau, R., Morin, J., Mourgues, R., Mousis, O., Nablanc, C., Nastasi, A., Niacsu, L., Notez, P., Ory, M., Pace, E., Paganelli, M. A., Pagola, A., Pajuelo, M., Palacian, J. F., Pallier, G., Paraschiv, P., Pardini, R., Pavone, M., Pavy, G., Payen, G., Pegoraro, A., Pena-Asensio, E., Perez, L., Perez-Hoyos, S., Perlerin, V., Peyrot, A., Peth, F., Pic, V., Pietronave, S., Pilger, C., Piquel, M., Pisanu, T., Poppe, M., Portois, L., Prezeau, J. F., Pugno, N., Quantin, C., Quitte, G., Rambaux, N., Ravier, E., Repetti, U., Ribas, S., Richard, C., Richard, D., Rigoni, M., Rivet, J. P., Rizzi, N., Rochain, S., Rojas, J. F., Romeo, M., Rotaru, M., Rotger, M., Rougier, P., Rousselot, P., Rousset, J., Rousseu, D., Rubiera, O., Rudawska, R., Rudelle, J., Ruguet, J. P., Russo, P., Sales, S., Sauzereau, O., Salvati, F., Schieffer, M., Schreiner, D., Scribano, Y., Selvestrel, D., Serra, R., Shengold, L., Shuttleworth, A., Smareglia, R., Sohy, S., Soldi, M., Stanga, R., Steinhausser, A., Strafella, F., Sylla Mbaye, S., Smedley, A. R. D., Tagger, M., Tanga, P., Taricco, C., Teng, J. P., Tercu, J. O., Thizy, O., Thomas, J. P., Tombelli, M., Trangosi, R., Tregon, B., Trivero, P., Tukkers, A., Turcu, V., Umbriaco, G., Unda-Sanzana, E., Vairetti, R., Valenzuela, M., Valente, G., Varennes, G., Vauclair, S., Vergne, J., Verlinden, M., Vidal-Alaiz, M., Vieira-Martins, R., Viel, A., Vintdevara, D. C., Vinogradoff, V., Volpini, P., Wendling, M., Wilhelm, P., Wohlgemuth, K., Yanguas, P., Zagarella, R., Zollo, A., Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa. INAMAT2 - Institute for Advanced Materials and Mathematics, Ferrière, L., Appéré, T., Bǎdescu, O., Boacă, I., Boatǎ, R., Bramond, Ph., D’Agostino, G., Dǎnescu, C., D’Elia, M., Deverchère, P., Frîncu, M., Hyaumé, F., Laisné, E., Le Dû, P., Niacşu, L., Palacián, J. F., Peña-Asensio, E., Pérez-Hoyos, S., Quitté, G., Rojas, J.F., Ruguet, J.P., Vîntdevarǎ, D. C., Research unit Medical Physics, and Damage and Repair in Cancer Development and Cancer Treatment (DARE)

Subjects
DYNAMICS, [INFO.INFO-AR]Computer Science [cs]/Hardware Architecture [cs.AR], Meteors, Computer science, Radio receiver, [INFO.INFO-DM]Computer Science [cs]/Discrete Mathematics [cs.DM], Surveys, 010502 geochemistry & geophysics, Track (rail transport), 01 natural sciences, Meteorites, meteors, meteoroids, law.invention, Planets and planetary system, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Methods: observational, law, [INFO.INFO-RB]Computer Science [cs]/Robotics [cs.RO], meteoroids, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, Observational methods, Earth and Planetary Astrophysics (astro-ph.EP), meteoroids -surveys -methods: observational -interplanetary medium, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], ORIGIN, [INFO.INFO-AO]Computer Science [cs]/Computer Arithmetic, meteorites, meteors, meteoroids – surveys – methods: observational – interplanetary medium, Meteoroids, RECOVERY, ORBIT, Meteorite, Fully automated, Interplanetary medium, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], [INFO.INFO-DC]Computer Science [cs]/Distributed, Parallel, and Cluster Computing [cs.DC], Astrophysics - Instrumentation and Methods for Astrophysics, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, FLUX, Real-time computing, fripon, [INFO.INFO-DS]Computer Science [cs]/Data Structures and Algorithms [cs.DS], FOS: Physical sciences, Context (language use), CAMERA, [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], [SPI.AUTO]Engineering Sciences [physics]/Automatic, [SDU.STU.PL]Sciences of the Universe [physics]/Earth Sciences/Planetology, 0103 physical sciences, FIREBALL NETWORK, observational [Methods], meteors, Instrumentation and Methods for Astrophysics (astro-ph.IM), 0105 earth and related environmental sciences, Meteoroid, INNISFREE METEORITE, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], Astronomy and Astrophysics, METEORITE FALL, Meteorites, meteors, meteoroid, Camera network, Space and Planetary Science, [SDU]Sciences of the Universe [physics], Interplanetary spaceflight, meteroids tracking, meteoroids - surveys - methods: observational, SYSTEM, Astrophysics - Earth and Planetary Astrophysics, Meteorites
Abstract

Context. Until recently, camera networks designed for monitoring fireballs worldwide were not fully automated, implying that in case of a meteorite fall, the recovery campaign was rarely immediate. This was an important limiting factor as the most fragile - hence precious - meteorites must be recovered rapidly to avoid their alteration. Aims. The Fireball Recovery and InterPlanetary Observation Network (FRIPON) scientific project was designed to overcome this limitation. This network comprises a fully automated camera and radio network deployed over a significant fraction of western Europe and a small fraction of Canada. As of today, it consists of 150 cameras and 25 European radio receivers and covers an area of about 1.5 × 10km. Methods. The FRIPON network, fully operational since 2018, has been monitoring meteoroid entries since 2016, thereby allowing the characterization of their dynamical and physical properties. In addition, the level of automation of the network makes it possible to trigger a meteorite recovery campaign only a few hours after it reaches the surface of the Earth. Recovery campaigns are only organized for meteorites with final masses estimated of at least 500 g, which is about one event per year in France. No recovery campaign is organized in the case of smaller final masses on the order of 50 to 100 g, which happens about three times a year; instead, the information is delivered to the local media so that it can reach the inhabitants living in the vicinity of the fall. Results. Nearly 4000 meteoroids have been detected so far and characterized by FRIPON. The distribution of their orbits appears to be bimodal, with a cometary population and a main belt population. Sporadic meteors amount to about 55% of all meteors. A first estimate of the absolute meteoroid flux (mag < -5; meteoroid size ≥∼1 cm) amounts to 1250/yr/10km. This value is compatible with previous estimates. Finally, the first meteorite was recovered in Italy (Cavezzo, January 2020) thanks to the PRISMA network, a component of the FRIPON science project., FRIPON was initiated by funding from ANR (grant N.13- BS05-0009-03), carried by the Paris Observatory, Muséum National d’Histoire Naturelle, Paris-Saclay University and Institut Pythéas (LAM-CEREGE). VigieCiel was part of the 65 Millions d’Observateurs project, carried by the Muséum National d’Histoire Naturelle and funded by the French Investissements d’Avenir program. FRIPON data are hosted and processed at Institut Pythéas SIP (Service Informatique Pythéas), and a mirror is hosted at IMCCE (Institut de Mécanique Céleste et de Calcul des Éphémérides / Paris Observatory) with the help of IDOC (https://idoc.ias.u-psud.fr) (Integrated Data and Operation Center), supported by CNRS and CNES. PRISMA is the Italian Network for Systematic surveillance of Meteors and Atmosphere. It is a collaboration initiated and coordinated by the Italian National Institute for Astrophysics (INAF) that counts members among research institutes, associations and schools (http://www.prisma.inaf.it). PRISMA was partially funded by 2016 and 2020 Research and Education grants from Fondazione Cassa di Risparmio di Torino and by a 2016 grant from Fondazione Agostino De Mari (Savona). FRIPON-Bilbao is supported by a grant from Diputacion Foral Bizkaia (DFB/BFA). FRIPONMOROI was supported by a grant of the Romanian Ministery of Research and Innovation, CCCDI - UEFISCDI, project number PN-III-P1-1.2-PCCDI2017-0226/16PCCDI/2018 , within PNCDI III. Rio de Janeiro camera is hosted and partially maintained by MAST (Museum of Astronomy and Related Sciences)/MCTIC. The Meteorix project acknowledges supports from labex ESEP (Exploration Spatiale des Environnements Planétaires), DIM-ACAV+ Région Île-de-France, Janus CNES, IDEX Sorbonne Universités and Sorbonne Université.

Published
2020

13. FRIPON: a worldwide network to track incoming meteoroids

Author

Colas, F., primary, Zanda, B., additional, Bouley, S., additional, Jeanne, S., additional, Malgoyre, A., additional, Birlan, M., additional, Blanpain, C., additional, Gattacceca, J., additional, Jorda, L., additional, Lecubin, J., additional, Marmo, C., additional, Rault, J. L., additional, Vaubaillon, J., additional, Vernazza, P., additional, Yohia, C., additional, Gardiol, D., additional, Nedelcu, A., additional, Poppe, B., additional, Rowe, J., additional, Forcier, M., additional, Koschny, D., additional, Trigo-Rodriguez, J. M., additional, Lamy, H., additional, Behrend, R., additional, Ferrière, L., additional, Barghini, D., additional, Buzzoni, A., additional, Carbognani, A., additional, Di Carlo, M., additional, Di Martino, M., additional, Knapic, C., additional, Londero, E., additional, Pratesi, G., additional, Rasetti, S., additional, Riva, W., additional, Stirpe, G. M., additional, Valsecchi, G. B., additional, Volpicelli, C. A., additional, Zorba, S., additional, Coward, D., additional, Drolshagen, E., additional, Drolshagen, G., additional, Hernandez, O., additional, Jehin, E., additional, Jobin, M., additional, King, A., additional, Nitschelm, C., additional, Ott, T., additional, Sanchez-Lavega, A., additional, Toni, A., additional, Abraham, P., additional, Affaticati, F., additional, Albani, M., additional, Andreis, A., additional, Andrieu, T., additional, Anghel, S., additional, Antaluca, E., additional, Antier, K., additional, Appéré, T., additional, Armand, A., additional, Ascione, G., additional, Audureau, Y., additional, Auxepaules, G., additional, Avoscan, T., additional, Baba Aissa, D., additional, Bacci, P., additional, Bǎdescu, O., additional, Baldini, R., additional, Baldo, R., additional, Balestrero, A., additional, Baratoux, D., additional, Barbotin, E., additional, Bardy, M., additional, Basso, S., additional, Bautista, O., additional, Bayle, L. D., additional, Beck, P., additional, Bellitto, R., additional, Belluso, R., additional, Benna, C., additional, Benammi, M., additional, Beneteau, E., additional, Benkhaldoun, Z., additional, Bergamini, P., additional, Bernardi, F., additional, Bertaina, M. E., additional, Bessin, P., additional, Betti, L., additional, Bettonvil, F., additional, Bihel, D., additional, Birnbaum, C., additional, Blagoi, O., additional, Blouri, E., additional, Boacă, I., additional, Boatǎ, R., additional, Bobiet, B., additional, Bonino, R., additional, Boros, K., additional, Bouchet, E., additional, Borgeot, V., additional, Bouchez, E., additional, Boust, D., additional, Boudon, V., additional, Bouman, T., additional, Bourget, P., additional, Brandenburg, S., additional, Bramond, Ph., additional, Braun, E., additional, Bussi, A., additional, Cacault, P., additional, Caillier, B., additional, Calegaro, A., additional, Camargo, J., additional, Caminade, S., additional, Campana, A. P. C., additional, Campbell-Burns, P., additional, Canal-Domingo, R., additional, Carell, O., additional, Carreau, S., additional, Cascone, E., additional, Cattaneo, C., additional, Cauhape, P., additional, Cavier, P., additional, Celestin, S., additional, Cellino, A., additional, Champenois, M., additional, Chennaoui Aoudjehane, H., additional, Chevrier, S., additional, Cholvy, P., additional, Chomier, L., additional, Christou, A., additional, Cricchio, D., additional, Coadou, P., additional, Cocaign, J. Y., additional, Cochard, F., additional, Cointin, S., additional, Colombi, E., additional, Colque Saavedra, J. P., additional, Corp, L., additional, Costa, M., additional, Costard, F., additional, Cottier, M., additional, Cournoyer, P., additional, Coustal, E., additional, Cremonese, G., additional, Cristea, O., additional, Cuzon, J. C., additional, D’Agostino, G., additional, Daiffallah, K., additional, Dǎnescu, C., additional, Dardon, A., additional, Dasse, T., additional, Davadan, C., additional, Debs, V., additional, Defaix, J. P., additional, Deleflie, F., additional, D’Elia, M., additional, De Luca, P., additional, De Maria, P., additional, Deverchère, P., additional, Devillepoix, H., additional, Dias, A., additional, Di Dato, A., additional, Di Luca, R., additional, Dominici, F. M., additional, Drouard, A., additional, Dumont, J. L., additional, Dupouy, P., additional, Duvignac, L., additional, Egal, A., additional, Erasmus, N., additional, Esseiva, N., additional, Ebel, A., additional, Eisengarten, B., additional, Federici, F., additional, Feral, S., additional, Ferrant, G., additional, Ferreol, E., additional, Finitzer, P., additional, Foucault, A., additional, Francois, P., additional, Frîncu, M., additional, Froger, J. L., additional, Gaborit, F., additional, Gagliarducci, V., additional, Galard, J., additional, Gardavot, A., additional, Garmier, M., additional, Garnung, M., additional, Gautier, B., additional, Gendre, B., additional, Gerard, D., additional, Gerardi, A., additional, Godet, J. P., additional, Grandchamps, A., additional, Grouiez, B., additional, Groult, S., additional, Guidetti, D., additional, Giuli, G., additional, Hello, Y., additional, Henry, X., additional, Herbreteau, G., additional, Herpin, M., additional, Hewins, P., additional, Hillairet, J. J., additional, Horak, J., additional, Hueso, R., additional, Huet, E., additional, Huet, S., additional, Hyaumé, F., additional, Interrante, G., additional, Isselin, Y., additional, Jeangeorges, Y., additional, Janeux, P., additional, Jeanneret, P., additional, Jobse, K., additional, Jouin, S., additional, Jouvard, J. M., additional, Joy, K., additional, Julien, J. F., additional, Kacerek, R., additional, Kaire, M., additional, Kempf, M., additional, Krier, C., additional, Kwon, M. K., additional, Lacassagne, L., additional, Lachat, D., additional, Lagain, A., additional, Laisné, E., additional, Lanchares, V., additional, Laskar, J., additional, Lazzarin, M., additional, Leblanc, M., additional, Lebreton, J. P., additional, Lecomte, J., additional, Le Dû, P., additional, Lelong, F., additional, Lera, S., additional, Leoni, J. F., additional, Le-Pichon, A., additional, Le-Poupon, P., additional, Leroy, A., additional, Leto, G., additional, Levansuu, A., additional, Lewin, E., additional, Lienard, A., additional, Licchelli, D., additional, Locatelli, H., additional, Loehle, S., additional, Loizeau, D., additional, Luciani, L., additional, Maignan, M., additional, Manca, F., additional, Mancuso, S., additional, Mandon, E., additional, Mangold, N., additional, Mannucci, F., additional, Maquet, L., additional, Marant, D., additional, Marchal, Y., additional, Marin, J. L., additional, Martin-Brisset, J. C., additional, Martin, D., additional, Mathieu, D., additional, Maury, A., additional, Mespoulet, N., additional, Meyer, F., additional, Meyer, J. Y., additional, Meza, E., additional, Moggi Cecchi, V., additional, Moiroud, J. J., additional, Millan, M., additional, Montesarchio, M., additional, Misiano, A., additional, Molinari, E., additional, Molau, S., additional, Monari, J., additional, Monflier, B., additional, Monkos, A., additional, Montemaggi, M., additional, Monti, G., additional, Moreau, R., additional, Morin, J., additional, Mourgues, R., additional, Mousis, O., additional, Nablanc, C., additional, Nastasi, A., additional, Niacşu, L., additional, Notez, P., additional, Ory, M., additional, Pace, E., additional, Paganelli, M. A., additional, Pagola, A., additional, Pajuelo, M., additional, Palacián, J. F., additional, Pallier, G., additional, Paraschiv, P., additional, Pardini, R., additional, Pavone, M., additional, Pavy, G., additional, Payen, G., additional, Pegoraro, A., additional, Peña-Asensio, E., additional, Perez, L., additional, Pérez-Hoyos, S., additional, Perlerin, V., additional, Peyrot, A., additional, Peth, F., additional, Pic, V., additional, Pietronave, S., additional, Pilger, C., additional, Piquel, M., additional, Pisanu, T., additional, Poppe, M., additional, Portois, L., additional, Prezeau, J. F., additional, Pugno, N., additional, Quantin, C., additional, Quitté, G., additional, Rambaux, N., additional, Ravier, E., additional, Repetti, U., additional, Ribas, S., additional, Richard, C., additional, Richard, D., additional, Rigoni, M., additional, Rivet, J. P., additional, Rizzi, N., additional, Rochain, S., additional, Rojas, J.F., additional, Romeo, M., additional, Rotaru, M., additional, Rotger, M., additional, Rougier, P., additional, Rousselot, P., additional, Rousset, J., additional, Rousseu, D., additional, Rubiera, O., additional, Rudawska, R., additional, Rudelle, J., additional, Ruguet, J.P., additional, Russo, P., additional, Sales, S., additional, Sauzereau, O., additional, Salvati, F., additional, Schieffer, M., additional, Schreiner, D., additional, Scribano, Y., additional, Selvestrel, D., additional, Serra, R., additional, Shengold, L., additional, Shuttleworth, A., additional, Smareglia, R., additional, Sohy, S., additional, Soldi, M., additional, Stanga, R., additional, Steinhausser, A., additional, Strafella, F., additional, Sylla Mbaye, S., additional, Smedley, A. R. D., additional, Tagger, M., additional, Tanga, P., additional, Taricco, C., additional, Teng, J. P., additional, Tercu, J. O., additional, Thizy, O., additional, Thomas, J. P., additional, Tombelli, M., additional, Trangosi, R., additional, Tregon, B., additional, Trivero, P., additional, Tukkers, A., additional, Turcu, V., additional, Umbriaco, G., additional, Unda-Sanzana, E., additional, Vairetti, R., additional, Valenzuela, M., additional, Valente, G., additional, Varennes, G., additional, Vauclair, S., additional, Vergne, J., additional, Verlinden, M., additional, Vidal-Alaiz, M., additional, Vieira-Martins, R., additional, Viel, A., additional, Vîntdevarǎ, D. C., additional, Vinogradoff, V., additional, Volpini, P., additional, Wendling, M., additional, Wilhelm, P., additional, Wohlgemuth, K., additional, Yanguas, P., additional, Zagarella, R., additional, and Zollo, A., additional

Published
2020
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14. Large-gap AC coplanar plasma display cells: macro-cell experiments and 3-D simulations

Author

Ouyang, J., Callegari, Th., Caillier, B., and Boeuf, J.P.

Subjects
Plasma display, Business, Chemistry, Electronics, Electronics and electrical industries
Abstract

We present experimental and simulation studies of the plasma in a macroscopic ac plasma display panel discharge cell operating with a large coplanar gap. We find that the xenon excitation efficiency is much larger than that in the conventional, small-gap electrode configuration hut with larger sustaining voltage. We discuss the discharge mode and efficiency in such large gap configurations, with the help of time resolved optical diagnostics and simulations. Index Terms--Dielectric barrier discharges, discharge simulation, glow discharge plasma, plasma display panel (PDP), ultraviolet (UV) emission.

Published
2003

20. Atmospheric plasma-assisted modification of nanosized LiYF4:Eu3+ with gold nanoparticles.

Author

Gonçalves, João Marcos, Guillot, Ph., Caiut, J. M. A., and Caillier, B.

Subjects
GOLD nanoparticles, SURFACE plasmon resonance, HELIUM plasmas, PLASMA jets, SURFACE energy
Abstract

Both gold and rare-earth doped fluoride nanoparticles have been drawing interest for their possible biological applications, for therapy or for bioimaging. Gold nanoparticles can be used as a heat source for photothermal therapy, absorbing energy through its surface plasmon resonance (SPR) band and converting it to heat, whereas the low phonon energy, long emission lifetimes and sharp emission lines of the fluoride nanoparticles can circumvent several drawbacks of other used materials for bioimaging. In this context, this article proposes a modification of nanosized europium doped-LiYF4 with gold nanoparticles using a helium atmospheric plasma to reduce Au3+ to form the gold nanoparticles. In this article, we successfully synthesized citrate stabilized gold nanoparticles assisted by a helium atmospheric plasma, which showed a broad size distribution between 30 and 109 nm and different shapes, and a SPR band at 544 nm. We also successfully modified LiYF4:Eu3+ with gold nanoparticles with the atmospheric plasma jet, which presented a SPR band at 539 nm and significantly suppressed europium luminescence possibly due to the absorption of the emitted photons of the Eu3+ by the gold SPR band. [ABSTRACT FROM AUTHOR]

Published
2019
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21. Elaboration of phosphor particles with spherical shape and micronic size

Author

Joffin, Nicolas, Dexpert-Ghys, Jeannette, Garcia, A, Verelst, Marc, Schamm-Chardon, Sylvie, Caillier, B, Baret, G, Centre d'élaboration de matériaux et d'études structurales (CEMES), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Plasmas de Toulouse (CPAT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), DGTec, Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), and Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics]
Abstract

International audience; Red phosphor (Y2O3:Eu) and green phosphor (Zn2SiO4:Mn) powders with a spherical shape and an average diameter of Dv50 = 3.2 +/-0.2 mum have been prepared by the technique of spray-pyrolysis and optimal post-synthetic heat treatments. The photo-luminescence of these powders under excitation in the UV-VUV are measured and compared with those of commercial phosphors used in plasma display panels. Additional characterizations are presented.

Published
2004

23. Electrical Diagnostics of a Macroscopic rf Plasma Display Panel Cell

Author

TOULOUSE-3 UNIV (FRANCE), Caillier, B., Guillot, Ph., Galy, J., Pitchford, L. C., Boeuf, J. P., TOULOUSE-3 UNIV (FRANCE), Caillier, B., Guillot, Ph., Galy, J., Pitchford, L. C., and Boeuf, J. P.

Abstract

Although Plasma Display Panels (PDPs) are now produced industrially, their luminous efficiency is still low, on the order of2 lumens per watt (lm/W) or less, and needs to be increased up to 5 lm/W. Research efforts are directed toward the increase of efficiency by optimization of the electrode and cell design or by seeking more efficient discharge regimes. Recently some attempts at operating PDP cells in a RF regime have been made'. The RF regime is much more efficient than the usual dielectric barrier discharge ac regime because the better electron confinement allows lower operating voltages. Less energy is therefore dissipated in ion heating in the sheaths, and the lower electric field allows a more efficient energy deposition into xenon excitation (the efficiency of the PDP cell is directly related to the UV emission of the xenon resonant and excimer states., Pub. in International Conference on Phenomena in Ionized Gases (26th), v4 p129-130, July 2003. This article is from ADA421147 International Conference on Phenomena in Ionized Gases (26th) Held in Greifswald, Germany on 15-20 July 2003. Proceedings, Volume 4

Published
2003

29. FRIPON: a worldwide network to track incoming meteoroids

Author

Colas, F., Zanda, B., Bouley, S., Jeanne, S., Malgoyre, A., Birlan, M., Blanpain, C., Gattacceca, J., Jorda, L., Lecubin, J., Marmo, C., Rault, J. L., Vaubaillon, J., Vernazza, P., Yohia, C., Gardiol, D., Nedelcu, A., Poppe, B., Rowe, J., Forcier, M., Koschny, D., Trigo-Rodriguez, J. M., Lamy, H., Behrend, R., Ferrière, L., Barghini, D., Buzzoni, A., Carbognani, A., Di Carlo, M., Di Martino, M., Knapic, C., Londero, E., Pratesi, G., Rasetti, S., Riva, W., Stirpe, G. M., Valsecchi, G. B., Volpicelli, C. A., Zorba, S., Coward, D., Drolshagen, E., Drolshagen, G., Hernandez, O., Jehin, E., Jobin, M., King, A., Nitschelm, C., Ott, T., Sanchez-Lavega, A., Toni, A., Abraham, P., Affaticati, F., Albani, M., Andreis, A., Andrieu, T., Anghel, S., Antaluca, E., Antier, K., Appéré, T., Armand, A., Ascione, G., Audureau, Y., Auxepaules, G., Avoscan, T., Baba Aissa, D., Bacci, P., Bǎdescu, O., Baldini, R., Baldo, R., Balestrero, A., Baratoux, D., Barbotin, E., Bardy, M., Basso, S., Bautista, O., Bayle, L. D., Beck, P., Bellitto, R., Belluso, R., Benna, C., Benammi, M., Beneteau, E., Benkhaldoun, Z., Bergamini, P., Bernardi, F., Bertaina, M. E., Bessin, P., Betti, L., Bettonvil, F., Bihel, D., Birnbaum, C., Blagoi, O., Blouri, E., Boacă, I., Boatǎ, R., Bobiet, B., Bonino, R., Boros, K., Bouchet, E., Borgeot, V., Bouchez, E., Boust, D., Boudon, V., Bouman, T., Bourget, P., Brandenburg, S., Bramond, Ph., Braun, E., Bussi, A., Cacault, P., Caillier, B., Calegaro, A., Camargo, J., Caminade, S., Campana, A. P. C., Campbell-Burns, P., Canal-Domingo, R., Carell, O., Carreau, S., Cascone, E., Cattaneo, C., Cauhape, P., Cavier, P., Celestin, S., Cellino, A., Champenois, M., Chennaoui Aoudjehane, H., Chevrier, S., Cholvy, P., Chomier, L., Christou, A., Cricchio, D., Coadou, P., Cocaign, J. Y., Cochard, F., Cointin, S., Colombi, E., Colque Saavedra, J. P., Corp, L., Costa, M., Costard, F., Cottier, M., Cournoyer, P., Coustal, E., Cremonese, G., Cristea, O., Cuzon, J. C., D’Agostino, G., Daiffallah, K., Dǎnescu, C., Dardon, A., Dasse, T., Davadan, C., Debs, V., Defaix, J. P., Deleflie, F., D’Elia, M., De Luca, P., De Maria, P., Deverchère, P., Devillepoix, H., Dias, A., Di Dato, A., Di Luca, R., Dominici, F. M., Drouard, A., Dumont, J. L., Dupouy, P., Duvignac, L., Egal, A., Erasmus, N., Esseiva, N., Ebel, A., Eisengarten, B., Federici, F., Feral, S., Ferrant, G., Ferreol, E., Finitzer, P., Foucault, A., Francois, P., Frîncu, M., Froger, J. L., Gaborit, F., Gagliarducci, V., Galard, J., Gardavot, A., Garmier, M., Garnung, M., Gautier, B., Gendre, B., Gerard, D., Gerardi, A., Godet, J. P., Grandchamps, A., Grouiez, B., Groult, S., Guidetti, D., Giuli, G., Hello, Y., Henry, X., Herbreteau, G., Herpin, M., Hewins, P., Hillairet, J. J., Horak, J., Hueso, R., Huet, E., Huet, S., Hyaumé, F., Interrante, G., Isselin, Y., Jeangeorges, Y., Janeux, P., Jeanneret, P., Jobse, K., Jouin, S., Jouvard, J. M., Joy, K., Julien, J. F., Kacerek, R., Kaire, M., Kempf, M., Krier, C., Kwon, M. K., Lacassagne, L., Lachat, D., Lagain, A., Laisné, E., Lanchares, V., Laskar, J., Lazzarin, M., Leblanc, M., Lebreton, J. P., Lecomte, J., Le Dû, P., Lelong, F., Lera, S., Leoni, J. F., Le-Pichon, A., Le-Poupon, P., Leroy, A., Leto, G., Levansuu, A., Lewin, E., Lienard, A., Licchelli, D., Locatelli, H., Loehle, S., Loizeau, D., Luciani, L., Maignan, M., Manca, F., Mancuso, S., Mandon, E., Mangold, N., Mannucci, F., Maquet, L., Marant, D., Marchal, Y., Marin, J. L., Martin-Brisset, J. C., Martin, D., Mathieu, D., Maury, A., Mespoulet, N., Meyer, F., Meyer, J. Y., Meza, E., Moggi Cecchi, V., Moiroud, J. J., Millan, M., Montesarchio, M., Misiano, A., Molinari, E., Molau, S., Monari, J., Monflier, B., Monkos, A., Montemaggi, M., Monti, G., Moreau, R., Morin, J., Mourgues, R., Mousis, O., Nablanc, C., Nastasi, A., Niacşu, L., Notez, P., Ory, M., Pace, E., Paganelli, M. A., Pagola, A., Pajuelo, M., Palacián, J. F., Pallier, G., Paraschiv, P., Pardini, R., Pavone, M., Pavy, G., Payen, G., Pegoraro, A., Peña-Asensio, E., Perez, L., Pérez-Hoyos, S., Perlerin, V., Peyrot, A., Peth, F., Pic, V., Pietronave, S., Pilger, C., Piquel, M., Pisanu, T., Poppe, M., Portois, L., Prezeau, J. F., Pugno, N., Quantin, C., Quitté, G., Rambaux, N., Ravier, E., Repetti, U., Ribas, S., Richard, C., Richard, D., Rigoni, M., Rivet, J. P., Rizzi, N., Rochain, S., Rojas, J.F., Romeo, M., Rotaru, M., Rotger, M., Rougier, P., Rousselot, P., Rousset, J., Rousseu, D., Rubiera, O., Rudawska, R., Rudelle, J., Ruguet, J.P., Russo, P., Sales, S., Sauzereau, O., Salvati, F., Schieffer, M., Schreiner, D., Scribano, Y., Selvestrel, D., Serra, R., Shengold, L., Shuttleworth, A., Smareglia, R., Sohy, S., Soldi, M., Stanga, R., Steinhausser, A., Strafella, F., Sylla Mbaye, S., Smedley, A. R. D., Tagger, M., Tanga, P., Taricco, C., Teng, J. P., Tercu, J. O., Thizy, O., Thomas, J. P., Tombelli, M., Trangosi, R., Tregon, B., Trivero, P., Tukkers, A., Turcu, V., Umbriaco, G., Unda-Sanzana, E., Vairetti, R., Valenzuela, M., Valente, G., Varennes, G., Vauclair, S., Vergne, J., Verlinden, M., Vidal-Alaiz, M., Vieira-Martins, R., Viel, A., Vîntdevarǎ, D. C., Vinogradoff, V., Volpini, P., Wendling, M., Wilhelm, P., Wohlgemuth, K., Yanguas, P., Zagarella, R., Zollo, A., Colas, F., Zanda, B., Bouley, S., Jeanne, S., Malgoyre, A., Birlan, M., Blanpain, C., Gattacceca, J., Jorda, L., Lecubin, J., Marmo, C., Rault, J. L., Vaubaillon, J., Vernazza, P., Yohia, C., Gardiol, D., Nedelcu, A., Poppe, B., Rowe, J., Forcier, M., Koschny, D., Trigo-Rodriguez, J. M., Lamy, H., Behrend, R., Ferrière, L., Barghini, D., Buzzoni, A., Carbognani, A., Di Carlo, M., Di Martino, M., Knapic, C., Londero, E., Pratesi, G., Rasetti, S., Riva, W., Stirpe, G. M., Valsecchi, G. B., Volpicelli, C. A., Zorba, S., Coward, D., Drolshagen, E., Drolshagen, G., Hernandez, O., Jehin, E., Jobin, M., King, A., Nitschelm, C., Ott, T., Sanchez-Lavega, A., Toni, A., Abraham, P., Affaticati, F., Albani, M., Andreis, A., Andrieu, T., Anghel, S., Antaluca, E., Antier, K., Appéré, T., Armand, A., Ascione, G., Audureau, Y., Auxepaules, G., Avoscan, T., Baba Aissa, D., Bacci, P., Bǎdescu, O., Baldini, R., Baldo, R., Balestrero, A., Baratoux, D., Barbotin, E., Bardy, M., Basso, S., Bautista, O., Bayle, L. D., Beck, P., Bellitto, R., Belluso, R., Benna, C., Benammi, M., Beneteau, E., Benkhaldoun, Z., Bergamini, P., Bernardi, F., Bertaina, M. E., Bessin, P., Betti, L., Bettonvil, F., Bihel, D., Birnbaum, C., Blagoi, O., Blouri, E., Boacă, I., Boatǎ, R., Bobiet, B., Bonino, R., Boros, K., Bouchet, E., Borgeot, V., Bouchez, E., Boust, D., Boudon, V., Bouman, T., Bourget, P., Brandenburg, S., Bramond, Ph., Braun, E., Bussi, A., Cacault, P., Caillier, B., Calegaro, A., Camargo, J., Caminade, S., Campana, A. P. C., Campbell-Burns, P., Canal-Domingo, R., Carell, O., Carreau, S., Cascone, E., Cattaneo, C., Cauhape, P., Cavier, P., Celestin, S., Cellino, A., Champenois, M., Chennaoui Aoudjehane, H., Chevrier, S., Cholvy, P., Chomier, L., Christou, A., Cricchio, D., Coadou, P., Cocaign, J. Y., Cochard, F., Cointin, S., Colombi, E., Colque Saavedra, J. P., Corp, L., Costa, M., Costard, F., Cottier, M., Cournoyer, P., Coustal, E., Cremonese, G., Cristea, O., Cuzon, J. C., D’Agostino, G., Daiffallah, K., Dǎnescu, C., Dardon, A., Dasse, T., Davadan, C., Debs, V., Defaix, J. P., Deleflie, F., D’Elia, M., De Luca, P., De Maria, P., Deverchère, P., Devillepoix, H., Dias, A., Di Dato, A., Di Luca, R., Dominici, F. M., Drouard, A., Dumont, J. L., Dupouy, P., Duvignac, L., Egal, A., Erasmus, N., Esseiva, N., Ebel, A., Eisengarten, B., Federici, F., Feral, S., Ferrant, G., Ferreol, E., Finitzer, P., Foucault, A., Francois, P., Frîncu, M., Froger, J. L., Gaborit, F., Gagliarducci, V., Galard, J., Gardavot, A., Garmier, M., Garnung, M., Gautier, B., Gendre, B., Gerard, D., Gerardi, A., Godet, J. P., Grandchamps, A., Grouiez, B., Groult, S., Guidetti, D., Giuli, G., Hello, Y., Henry, X., Herbreteau, G., Herpin, M., Hewins, P., Hillairet, J. J., Horak, J., Hueso, R., Huet, E., Huet, S., Hyaumé, F., Interrante, G., Isselin, Y., Jeangeorges, Y., Janeux, P., Jeanneret, P., Jobse, K., Jouin, S., Jouvard, J. M., Joy, K., Julien, J. F., Kacerek, R., Kaire, M., Kempf, M., Krier, C., Kwon, M. K., Lacassagne, L., Lachat, D., Lagain, A., Laisné, E., Lanchares, V., Laskar, J., Lazzarin, M., Leblanc, M., Lebreton, J. P., Lecomte, J., Le Dû, P., Lelong, F., Lera, S., Leoni, J. F., Le-Pichon, A., Le-Poupon, P., Leroy, A., Leto, G., Levansuu, A., Lewin, E., Lienard, A., Licchelli, D., Locatelli, H., Loehle, S., Loizeau, D., Luciani, L., Maignan, M., Manca, F., Mancuso, S., Mandon, E., Mangold, N., Mannucci, F., Maquet, L., Marant, D., Marchal, Y., Marin, J. L., Martin-Brisset, J. C., Martin, D., Mathieu, D., Maury, A., Mespoulet, N., Meyer, F., Meyer, J. Y., Meza, E., Moggi Cecchi, V., Moiroud, J. J., Millan, M., Montesarchio, M., Misiano, A., Molinari, E., Molau, S., Monari, J., Monflier, B., Monkos, A., Montemaggi, M., Monti, G., Moreau, R., Morin, J., Mourgues, R., Mousis, O., Nablanc, C., Nastasi, A., Niacşu, L., Notez, P., Ory, M., Pace, E., Paganelli, M. A., Pagola, A., Pajuelo, M., Palacián, J. F., Pallier, G., Paraschiv, P., Pardini, R., Pavone, M., Pavy, G., Payen, G., Pegoraro, A., Peña-Asensio, E., Perez, L., Pérez-Hoyos, S., Perlerin, V., Peyrot, A., Peth, F., Pic, V., Pietronave, S., Pilger, C., Piquel, M., Pisanu, T., Poppe, M., Portois, L., Prezeau, J. F., Pugno, N., Quantin, C., Quitté, G., Rambaux, N., Ravier, E., Repetti, U., Ribas, S., Richard, C., Richard, D., Rigoni, M., Rivet, J. P., Rizzi, N., Rochain, S., Rojas, J.F., Romeo, M., Rotaru, M., Rotger, M., Rougier, P., Rousselot, P., Rousset, J., Rousseu, D., Rubiera, O., Rudawska, R., Rudelle, J., Ruguet, J.P., Russo, P., Sales, S., Sauzereau, O., Salvati, F., Schieffer, M., Schreiner, D., Scribano, Y., Selvestrel, D., Serra, R., Shengold, L., Shuttleworth, A., Smareglia, R., Sohy, S., Soldi, M., Stanga, R., Steinhausser, A., Strafella, F., Sylla Mbaye, S., Smedley, A. R. D., Tagger, M., Tanga, P., Taricco, C., Teng, J. P., Tercu, J. O., Thizy, O., Thomas, J. P., Tombelli, M., Trangosi, R., Tregon, B., Trivero, P., Tukkers, A., Turcu, V., Umbriaco, G., Unda-Sanzana, E., Vairetti, R., Valenzuela, M., Valente, G., Varennes, G., Vauclair, S., Vergne, J., Verlinden, M., Vidal-Alaiz, M., Vieira-Martins, R., Viel, A., Vîntdevarǎ, D. C., Vinogradoff, V., Volpini, P., Wendling, M., Wilhelm, P., Wohlgemuth, K., Yanguas, P., Zagarella, R., and Zollo, A.

Abstract

Context. Until recently, camera networks designed for monitoring fireballs worldwide were not fully automated, implying that in case of a meteorite fall, the recovery campaign was rarely immediate. This was an important limiting factor as the most fragile – hence precious – meteorites must be recovered rapidly to avoid their alteration. Aims. The Fireball Recovery and InterPlanetary Observation Network (FRIPON) scientific project was designed to overcome this limitation. This network comprises a fully automated camera and radio network deployed over a significant fraction of western Europe and a small fraction of Canada. As of today, it consists of 150 cameras and 25 European radio receivers and covers an area of about 1.5 × 106 km2. Methods. The FRIPON network, fully operational since 2018, has been monitoring meteoroid entries since 2016, thereby allowing the characterization of their dynamical and physical properties. In addition, the level of automation of the network makes it possible to trigger a meteorite recovery campaign only a few hours after it reaches the surface of the Earth. Recovery campaigns are only organized for meteorites with final masses estimated of at least 500 g, which is about one event per year in France. No recovery campaign is organized in the case of smaller final masses on the order of 50 to 100 g, which happens about three times a year; instead, the information is delivered to the local media so that it can reach the inhabitants living in the vicinity of the fall. Results. Nearly 4000 meteoroids have been detected so far and characterized by FRIPON. The distribution of their orbits appears to be bimodal, with a cometary population and a main belt population. Sporadic meteors amount to about 55% of all meteors. A first estimate of the absolute meteoroid flux (mag < –5; meteoroid size ≥~1 cm) amounts to 1250/yr/106 km

30. FRIPON: a worldwide network to track incoming meteoroids

Author

Colas, F., Zanda, B., Bouley, S., Jeanne, S., Malgoyre, A., Birlan, M., Blanpain, C., Gattacceca, J., Jorda, L., Lecubin, J., Marmo, C., Rault, J. L., Vaubaillon, J., Vernazza, P., Yohia, C., Gardiol, D., Nedelcu, A., Poppe, B., Rowe, J., Forcier, M., Koschny, D., Trigo-Rodriguez, J. M., Lamy, H., Behrend, R., Ferrière, L., Barghini, D., Buzzoni, A., Carbognani, A., Di Carlo, M., Di Martino, M., Knapic, C., Londero, E., Pratesi, G., Rasetti, S., Riva, W., Stirpe, G. M., Valsecchi, G. B., Volpicelli, C. A., Zorba, S., Coward, D., Drolshagen, E., Drolshagen, G., Hernandez, O., Jehin, E., Jobin, M., King, A., Nitschelm, C., Ott, T., Sanchez-Lavega, A., Toni, A., Abraham, P., Affaticati, F., Albani, M., Andreis, A., Andrieu, T., Anghel, S., Antaluca, E., Antier, K., Appéré, T., Armand, A., Ascione, G., Audureau, Y., Auxepaules, G., Avoscan, T., Baba Aissa, D., Bacci, P., Bǎdescu, O., Baldini, R., Baldo, R., Balestrero, A., Baratoux, D., Barbotin, E., Bardy, M., Basso, S., Bautista, O., Bayle, L. D., Beck, P., Bellitto, R., Belluso, R., Benna, C., Benammi, M., Beneteau, E., Benkhaldoun, Z., Bergamini, P., Bernardi, F., Bertaina, M. E., Bessin, P., Betti, L., Bettonvil, F., Bihel, D., Birnbaum, C., Blagoi, O., Blouri, E., Boacă, I., Boatǎ, R., Bobiet, B., Bonino, R., Boros, K., Bouchet, E., Borgeot, V., Bouchez, E., Boust, D., Boudon, V., Bouman, T., Bourget, P., Brandenburg, S., Bramond, Ph., Braun, E., Bussi, A., Cacault, P., Caillier, B., Calegaro, A., Camargo, J., Caminade, S., Campana, A. P. C., Campbell-Burns, P., Canal-Domingo, R., Carell, O., Carreau, S., Cascone, E., Cattaneo, C., Cauhape, P., Cavier, P., Celestin, S., Cellino, A., Champenois, M., Chennaoui Aoudjehane, H., Chevrier, S., Cholvy, P., Chomier, L., Christou, A., Cricchio, D., Coadou, P., Cocaign, J. Y., Cochard, F., Cointin, S., Colombi, E., Colque Saavedra, J. P., Corp, L., Costa, M., Costard, F., Cottier, M., Cournoyer, P., Coustal, E., Cremonese, G., Cristea, O., Cuzon, J. C., D’Agostino, G., Daiffallah, K., Dǎnescu, C., Dardon, A., Dasse, T., Davadan, C., Debs, V., Defaix, J. P., Deleflie, F., D’Elia, M., De Luca, P., De Maria, P., Deverchère, P., Devillepoix, H., Dias, A., Di Dato, A., Di Luca, R., Dominici, F. M., Drouard, A., Dumont, J. L., Dupouy, P., Duvignac, L., Egal, A., Erasmus, N., Esseiva, N., Ebel, A., Eisengarten, B., Federici, F., Feral, S., Ferrant, G., Ferreol, E., Finitzer, P., Foucault, A., Francois, P., Frîncu, M., Froger, J. L., Gaborit, F., Gagliarducci, V., Galard, J., Gardavot, A., Garmier, M., Garnung, M., Gautier, B., Gendre, B., Gerard, D., Gerardi, A., Godet, J. P., Grandchamps, A., Grouiez, B., Groult, S., Guidetti, D., Giuli, G., Hello, Y., Henry, X., Herbreteau, G., Herpin, M., Hewins, P., Hillairet, J. J., Horak, J., Hueso, R., Huet, E., Huet, S., Hyaumé, F., Interrante, G., Isselin, Y., Jeangeorges, Y., Janeux, P., Jeanneret, P., Jobse, K., Jouin, S., Jouvard, J. M., Joy, K., Julien, J. F., Kacerek, R., Kaire, M., Kempf, M., Krier, C., Kwon, M. K., Lacassagne, L., Lachat, D., Lagain, A., Laisné, E., Lanchares, V., Laskar, J., Lazzarin, M., Leblanc, M., Lebreton, J. P., Lecomte, J., Le Dû, P., Lelong, F., Lera, S., Leoni, J. F., Le-Pichon, A., Le-Poupon, P., Leroy, A., Leto, G., Levansuu, A., Lewin, E., Lienard, A., Licchelli, D., Locatelli, H., Loehle, S., Loizeau, D., Luciani, L., Maignan, M., Manca, F., Mancuso, S., Mandon, E., Mangold, N., Mannucci, F., Maquet, L., Marant, D., Marchal, Y., Marin, J. L., Martin-Brisset, J. C., Martin, D., Mathieu, D., Maury, A., Mespoulet, N., Meyer, F., Meyer, J. Y., Meza, E., Moggi Cecchi, V., Moiroud, J. J., Millan, M., Montesarchio, M., Misiano, A., Molinari, E., Molau, S., Monari, J., Monflier, B., Monkos, A., Montemaggi, M., Monti, G., Moreau, R., Morin, J., Mourgues, R., Mousis, O., Nablanc, C., Nastasi, A., Niacşu, L., Notez, P., Ory, M., Pace, E., Paganelli, M. A., Pagola, A., Pajuelo, M., Palacián, J. F., Pallier, G., Paraschiv, P., Pardini, R., Pavone, M., Pavy, G., Payen, G., Pegoraro, A., Peña-Asensio, E., Perez, L., Pérez-Hoyos, S., Perlerin, V., Peyrot, A., Peth, F., Pic, V., Pietronave, S., Pilger, C., Piquel, M., Pisanu, T., Poppe, M., Portois, L., Prezeau, J. F., Pugno, N., Quantin, C., Quitté, G., Rambaux, N., Ravier, E., Repetti, U., Ribas, S., Richard, C., Richard, D., Rigoni, M., Rivet, J. P., Rizzi, N., Rochain, S., Rojas, J.F., Romeo, M., Rotaru, M., Rotger, M., Rougier, P., Rousselot, P., Rousset, J., Rousseu, D., Rubiera, O., Rudawska, R., Rudelle, J., Ruguet, J.P., Russo, P., Sales, S., Sauzereau, O., Salvati, F., Schieffer, M., Schreiner, D., Scribano, Y., Selvestrel, D., Serra, R., Shengold, L., Shuttleworth, A., Smareglia, R., Sohy, S., Soldi, M., Stanga, R., Steinhausser, A., Strafella, F., Sylla Mbaye, S., Smedley, A. R. D., Tagger, M., Tanga, P., Taricco, C., Teng, J. P., Tercu, J. O., Thizy, O., Thomas, J. P., Tombelli, M., Trangosi, R., Tregon, B., Trivero, P., Tukkers, A., Turcu, V., Umbriaco, G., Unda-Sanzana, E., Vairetti, R., Valenzuela, M., Valente, G., Varennes, G., Vauclair, S., Vergne, J., Verlinden, M., Vidal-Alaiz, M., Vieira-Martins, R., Viel, A., Vîntdevarǎ, D. C., Vinogradoff, V., Volpini, P., Wendling, M., Wilhelm, P., Wohlgemuth, K., Yanguas, P., Zagarella, R., Zollo, A., Colas, F., Zanda, B., Bouley, S., Jeanne, S., Malgoyre, A., Birlan, M., Blanpain, C., Gattacceca, J., Jorda, L., Lecubin, J., Marmo, C., Rault, J. L., Vaubaillon, J., Vernazza, P., Yohia, C., Gardiol, D., Nedelcu, A., Poppe, B., Rowe, J., Forcier, M., Koschny, D., Trigo-Rodriguez, J. M., Lamy, H., Behrend, R., Ferrière, L., Barghini, D., Buzzoni, A., Carbognani, A., Di Carlo, M., Di Martino, M., Knapic, C., Londero, E., Pratesi, G., Rasetti, S., Riva, W., Stirpe, G. M., Valsecchi, G. B., Volpicelli, C. A., Zorba, S., Coward, D., Drolshagen, E., Drolshagen, G., Hernandez, O., Jehin, E., Jobin, M., King, A., Nitschelm, C., Ott, T., Sanchez-Lavega, A., Toni, A., Abraham, P., Affaticati, F., Albani, M., Andreis, A., Andrieu, T., Anghel, S., Antaluca, E., Antier, K., Appéré, T., Armand, A., Ascione, G., Audureau, Y., Auxepaules, G., Avoscan, T., Baba Aissa, D., Bacci, P., Bǎdescu, O., Baldini, R., Baldo, R., Balestrero, A., Baratoux, D., Barbotin, E., Bardy, M., Basso, S., Bautista, O., Bayle, L. D., Beck, P., Bellitto, R., Belluso, R., Benna, C., Benammi, M., Beneteau, E., Benkhaldoun, Z., Bergamini, P., Bernardi, F., Bertaina, M. E., Bessin, P., Betti, L., Bettonvil, F., Bihel, D., Birnbaum, C., Blagoi, O., Blouri, E., Boacă, I., Boatǎ, R., Bobiet, B., Bonino, R., Boros, K., Bouchet, E., Borgeot, V., Bouchez, E., Boust, D., Boudon, V., Bouman, T., Bourget, P., Brandenburg, S., Bramond, Ph., Braun, E., Bussi, A., Cacault, P., Caillier, B., Calegaro, A., Camargo, J., Caminade, S., Campana, A. P. C., Campbell-Burns, P., Canal-Domingo, R., Carell, O., Carreau, S., Cascone, E., Cattaneo, C., Cauhape, P., Cavier, P., Celestin, S., Cellino, A., Champenois, M., Chennaoui Aoudjehane, H., Chevrier, S., Cholvy, P., Chomier, L., Christou, A., Cricchio, D., Coadou, P., Cocaign, J. Y., Cochard, F., Cointin, S., Colombi, E., Colque Saavedra, J. P., Corp, L., Costa, M., Costard, F., Cottier, M., Cournoyer, P., Coustal, E., Cremonese, G., Cristea, O., Cuzon, J. C., D’Agostino, G., Daiffallah, K., Dǎnescu, C., Dardon, A., Dasse, T., Davadan, C., Debs, V., Defaix, J. P., Deleflie, F., D’Elia, M., De Luca, P., De Maria, P., Deverchère, P., Devillepoix, H., Dias, A., Di Dato, A., Di Luca, R., Dominici, F. M., Drouard, A., Dumont, J. L., Dupouy, P., Duvignac, L., Egal, A., Erasmus, N., Esseiva, N., Ebel, A., Eisengarten, B., Federici, F., Feral, S., Ferrant, G., Ferreol, E., Finitzer, P., Foucault, A., Francois, P., Frîncu, M., Froger, J. L., Gaborit, F., Gagliarducci, V., Galard, J., Gardavot, A., Garmier, M., Garnung, M., Gautier, B., Gendre, B., Gerard, D., Gerardi, A., Godet, J. P., Grandchamps, A., Grouiez, B., Groult, S., Guidetti, D., Giuli, G., Hello, Y., Henry, X., Herbreteau, G., Herpin, M., Hewins, P., Hillairet, J. J., Horak, J., Hueso, R., Huet, E., Huet, S., Hyaumé, F., Interrante, G., Isselin, Y., Jeangeorges, Y., Janeux, P., Jeanneret, P., Jobse, K., Jouin, S., Jouvard, J. M., Joy, K., Julien, J. F., Kacerek, R., Kaire, M., Kempf, M., Krier, C., Kwon, M. K., Lacassagne, L., Lachat, D., Lagain, A., Laisné, E., Lanchares, V., Laskar, J., Lazzarin, M., Leblanc, M., Lebreton, J. P., Lecomte, J., Le Dû, P., Lelong, F., Lera, S., Leoni, J. F., Le-Pichon, A., Le-Poupon, P., Leroy, A., Leto, G., Levansuu, A., Lewin, E., Lienard, A., Licchelli, D., Locatelli, H., Loehle, S., Loizeau, D., Luciani, L., Maignan, M., Manca, F., Mancuso, S., Mandon, E., Mangold, N., Mannucci, F., Maquet, L., Marant, D., Marchal, Y., Marin, J. L., Martin-Brisset, J. C., Martin, D., Mathieu, D., Maury, A., Mespoulet, N., Meyer, F., Meyer, J. Y., Meza, E., Moggi Cecchi, V., Moiroud, J. J., Millan, M., Montesarchio, M., Misiano, A., Molinari, E., Molau, S., Monari, J., Monflier, B., Monkos, A., Montemaggi, M., Monti, G., Moreau, R., Morin, J., Mourgues, R., Mousis, O., Nablanc, C., Nastasi, A., Niacşu, L., Notez, P., Ory, M., Pace, E., Paganelli, M. A., Pagola, A., Pajuelo, M., Palacián, J. F., Pallier, G., Paraschiv, P., Pardini, R., Pavone, M., Pavy, G., Payen, G., Pegoraro, A., Peña-Asensio, E., Perez, L., Pérez-Hoyos, S., Perlerin, V., Peyrot, A., Peth, F., Pic, V., Pietronave, S., Pilger, C., Piquel, M., Pisanu, T., Poppe, M., Portois, L., Prezeau, J. F., Pugno, N., Quantin, C., Quitté, G., Rambaux, N., Ravier, E., Repetti, U., Ribas, S., Richard, C., Richard, D., Rigoni, M., Rivet, J. P., Rizzi, N., Rochain, S., Rojas, J.F., Romeo, M., Rotaru, M., Rotger, M., Rougier, P., Rousselot, P., Rousset, J., Rousseu, D., Rubiera, O., Rudawska, R., Rudelle, J., Ruguet, J.P., Russo, P., Sales, S., Sauzereau, O., Salvati, F., Schieffer, M., Schreiner, D., Scribano, Y., Selvestrel, D., Serra, R., Shengold, L., Shuttleworth, A., Smareglia, R., Sohy, S., Soldi, M., Stanga, R., Steinhausser, A., Strafella, F., Sylla Mbaye, S., Smedley, A. R. D., Tagger, M., Tanga, P., Taricco, C., Teng, J. P., Tercu, J. O., Thizy, O., Thomas, J. P., Tombelli, M., Trangosi, R., Tregon, B., Trivero, P., Tukkers, A., Turcu, V., Umbriaco, G., Unda-Sanzana, E., Vairetti, R., Valenzuela, M., Valente, G., Varennes, G., Vauclair, S., Vergne, J., Verlinden, M., Vidal-Alaiz, M., Vieira-Martins, R., Viel, A., Vîntdevarǎ, D. C., Vinogradoff, V., Volpini, P., Wendling, M., Wilhelm, P., Wohlgemuth, K., Yanguas, P., Zagarella, R., and Zollo, A.

Abstract

Context. Until recently, camera networks designed for monitoring fireballs worldwide were not fully automated, implying that in case of a meteorite fall, the recovery campaign was rarely immediate. This was an important limiting factor as the most fragile – hence precious – meteorites must be recovered rapidly to avoid their alteration. Aims. The Fireball Recovery and InterPlanetary Observation Network (FRIPON) scientific project was designed to overcome this limitation. This network comprises a fully automated camera and radio network deployed over a significant fraction of western Europe and a small fraction of Canada. As of today, it consists of 150 cameras and 25 European radio receivers and covers an area of about 1.5 × 106 km2. Methods. The FRIPON network, fully operational since 2018, has been monitoring meteoroid entries since 2016, thereby allowing the characterization of their dynamical and physical properties. In addition, the level of automation of the network makes it possible to trigger a meteorite recovery campaign only a few hours after it reaches the surface of the Earth. Recovery campaigns are only organized for meteorites with final masses estimated of at least 500 g, which is about one event per year in France. No recovery campaign is organized in the case of smaller final masses on the order of 50 to 100 g, which happens about three times a year; instead, the information is delivered to the local media so that it can reach the inhabitants living in the vicinity of the fall. Results. Nearly 4000 meteoroids have been detected so far and characterized by FRIPON. The distribution of their orbits appears to be bimodal, with a cometary population and a main belt population. Sporadic meteors amount to about 55% of all meteors. A first estimate of the absolute meteoroid flux (mag < –5; meteoroid size ≥~1 cm) amounts to 1250/yr/106 km

32. OV-A-3.

Author

Caillier, B., Villeneuve, L., Barbier, O., and Guillemette, C.

Subjects
GENETIC polymorphisms, MEDICAL sciences, CLINICAL pharmacology, GENETIC transformation, XENOBIOTICS
Abstract

Background/aims: UDP-glucuronosyltransferase UGT1A3 is significant for the glucuronic acid conjugation of a diversity of endo- and xenobiotics in the liver. Considering the variability in UGT1A3-mediated hepatic glucuronidation activity, this study was designed to identify common UGT1A3 genetic variants and determine their potential for contributing to interindividual differences.Methods: Single nucleotide polymorphism (SNP) discovery was accomplished by resequencing DNA samples from healthy Caucasians. Haplotypes were inferred and population frequencies estimated using PHASE version 2.1. For functional analysis, we used HepG2 cells in transfection studies with UGT1A3/luciferase constructs and electromobility shift assays.Results: Sequence analysis revealed six UGT1A3 upstream SNPs and 4 common (3-26%) promoter region haplotypes were inferred. One of the promoter variants fell within a putative binding factor site for the hepatocyte nuclear factor (HNF)-1α at -148 and is associated with a significant decrease in luciferase activity. The −148 T>C variant significantly decreased by 50% the binding of the protein complex while the HNF1α-specific antibody was able to supershift entirely the DNA-protein complex.Conclusion: UGT1A3 common promoter haplotype variants modulate gene function, namely through a reduction of the HNF1α-mediated promoter activation, and might contribute to interindividual differences in UGT1A3-mediated glucuronidation.Clinical Pharmacology & Therapeutics (2005) 79, P35–P35; doi: 10.1016/j.clpt.2005.12.124 [ABSTRACT FROM AUTHOR]

Published
2006
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33. Synthesis of silver nanoparticles by atmospheric pressure plasma jet.

Author

Habib T, Caiut JMA, and Caillier B

Abstract

Silver nanoparticles are one of the most extensively used metallic nanomaterials due to their unusual physical and chemical properties as well as their promising applications in a wide range of different fields. In this study, a non-thermal atmospheric pressure helium plasma jet was used to successfully synthesize silver nanoparticles with silver nitrate as a precursor and trisodium citrate as a capping agent. The browning of the solution after only 5 min of plasma irradiation is a result of the surface plasmon resonance (SPR) from the obtained silver nanoparticles. The SPR was confirmed by the presence of an absorption band in the visible range between 400 and 450 nm demonstrated in the UV-vis spectra. The effect of different chemical parameters such as the concentration of silver nitrate and the concentration of citrate on the silver nanoparticles have been studied. These nanoparticles were further characterized using transmission electron microscopy and dynamic light scattering. Therefore, the plasma jet was advantageous to fast produce silver nanoparticles in friendly conditions. In addition, the used experimental setup allows further studies in different solvents conditions and with different capping agents. So, this methodology could be useful for the preparation of silver nanoparticles required for numerous applications such as bioactivity, catalysis, surface enhanced Raman scattering, and photonic., (© 2022 IOP Publishing Ltd.)

Published
2022
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34. Decontamination Efficiency of a DBD Lamp Containing an UV-C Emitting Phosphor.

Author

Caillier B, Caiut JM, Muja C, Demoucron J, Mauricot R, Dexpert-Ghys J, and Guillot P

Abstract

Among different physical and chemical agents, the UV radiation appears to be an important route for inactivation of resistant microorganisms. The present study introduces a new mercury-free Dielectric Barrier Discharge (DBD) flat lamp, where the biocide action comes from the UV emission produced by rare-earth phosphor obtained by spray pyrolysis, following plasma excitation. In this study, the emission intensity of the prototype lamp is tuned by controlling gas pressure and electrical power, 500 mbar and 15 W, corresponding to optimal conditions. In order to characterize the prototype lamp, the energetic output, temperature increase following lamp ignition and ozone production of the source were measured. The bactericidal experiments carried out showed excellent results for several gram-positive and gram-negative bacterial strains, thus demonstrating the high decontamination efficiency of the DBD flat lamp. Finally, the study of the external morphology of the microorganisms after the exposure to the UV emission suggested that other mechanisms than the bacterial DNA damage could be involved in the inactivation process., (© 2015 The American Society of Photobiology.)

Published
2015
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35. QRS widening and QT prolongation under bupropion: a unique cardiac electrophysiological profile.

Author

Caillier B, Pilote S, Castonguay A, Patoine D, Ménard-Desrosiers V, Vigneault P, Hreiche R, Turgeon J, Daleau P, De Koninck Y, Simard C, and Drolet B

Subjects
Animals, Antidepressive Agents, Second-Generation administration & dosage, Antidepressive Agents, Second-Generation pharmacology, Bupropion administration & dosage, Bupropion pharmacology, CHO Cells, Cell Communication drug effects, Cell Line, Cricetinae, Cricetulus, Drug Overdose, Electrocardiography, Electrophysiological Phenomena, Fluorescence Recovery After Photobleaching, Gap Junctions drug effects, Gap Junctions metabolism, Guinea Pigs, Humans, Inhibitory Concentration 50, Long QT Syndrome chemically induced, Male, Patch-Clamp Techniques, Potassium Channel Blockers administration & dosage, Potassium Channel Blockers pharmacology, Potassium Channel Blockers toxicity, Rats, Antidepressive Agents, Second-Generation toxicity, Bupropion toxicity, Glycyrrhetinic Acid pharmacology, Heptanol pharmacology
Abstract

QRS widening and QT prolongation are associated with bupropion. The objectives were to elucidate its cardiac electrophysiological properties. Patch-clamp technique was used to assess the I(Kr) -, I(Ks) -, and I(Na) -blocking effects of bupropion. Langendorff retroperfusion technique on isolated guinea-pig hearts was used to evaluate the MAPD(90) -, MAP amplitude-, phase 0 dV/dt-, and ECG-modulating effects of bupropion and of two gap junction intercellular communication inhibitors: glycyrrhetinic acid and heptanol. To evaluate their effects on cardiac intercellular communication, fluorescence recovery after photobleaching (FRAP) technique was used. Bupropion is an I(Kr) blocker. IC(50) was estimated at 34 μm. In contrast, bupropion had hardly any effect on I(Ks) and I(Na) . Bupropion had no significant MAPD(90) -modulating effect. However, as glycyrrhetinic acid and heptanol, bupropion caused important reductions in MAP amplitude and phase 0 dV/dt. A modest but significant QRS-widening effect of bupropion was also observed. FRAP experiments confirmed that bupropion inhibits gap junctional intercellular communication. QT prolongation during bupropion overdosage is due to its I(Kr) -blocking effect. QRS widening with bupropion is not related to cardiac sodium channel block. Bupropion rather mimics the QRS-widening, MAP amplitude- and phase 0 dV/dt -reducing effect of glycyrrhetinic acid and heptanol. Unlike class I anti-arrhythmics, bupropion causes cardiac conduction disturbances by reducing cardiac intercellular coupling., (© 2011 The Authors Fundamental and Clinical Pharmacology © 2011 Société Française de Pharmacologie et de Thérapeutique.)

Published
2012
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36. Galantamine (Reminyl) delays cardiac ventricular repolarization and prolongs the QT interval by blocking the HERG current.

Author

Vigneault P, Bourgault S, Kaddar N, Caillier B, Pilote S, Patoine D, Simard C, and Drolet B

Subjects
Action Potentials drug effects, Animals, Cholinesterase Inhibitors administration & dosage, Dose-Response Relationship, Drug, Electrocardiography, Galantamine administration & dosage, Guinea Pigs, Inhibitory Concentration 50, Injections, Intraperitoneal, KCNQ1 Potassium Channel antagonists & inhibitors, Male, Patch-Clamp Techniques, Potassium Channels, Voltage-Gated antagonists & inhibitors, Cholinesterase Inhibitors toxicity, Ether-A-Go-Go Potassium Channels antagonists & inhibitors, Galantamine toxicity, Long QT Syndrome chemically induced
Abstract

Galantamine is a reversible inhibitor of acetylcholinesterase and an allosteric-potentiating ligand of the nicotinic acetylcholine receptors. It is used for treating mild-to-moderate Alzheimer's disease. Interestingly, QT interval prolongation on the electrocardiogram (ECG), malignant ventricular arrhythmias and syncope have been reported with galantamine. Our objective was to evaluate the effects of galantamine on cardiac ventricular repolarization. Three sets of experiments were undertaken: 1) Whole cell patch-clamp experiments: HERG- or KCNQ1+KCNE1-transfected cells were exposed to galantamine 0.1-1000 μmol/l (n=25 cells, total) to assess drug effect on HERG and KCNQ1+KCNE1 currents. 2) Langendorff perfusion experiments: Isolated hearts from male Hartley guinea pigs (n=9) were exposed to galantamine 1 μmol/l to assess drug-induced prolongation of monophasic action potential duration measured at 90% repolarization (MAPD(90)). 3) Cardiac telemetry experiments: Guinea pigs (n=7) implanted with wireless transmitters were injected a single intraperitoneal (i.p.) dose of galantamine 3mg/kg and 24h ECG recordings were made. 1) The estimated IC(50) for galantamine on HERG current was 760.2 μmol/l. Moreover, galantamine 10 μmol/l had a small inhibiting effect on KCNQ1+KCNE1 current (12.17 ± 2.19% inhibition, n=10 cells). 2) While pacing at cycle lengths of 150, 200 or 250 ms, galantamine 1 μmol/l prolonged MAPD(90) by respectively 5.1 ± 1.6 ms, 9.4 ± 1.9 ms and 12.1 ± 2.1 ms. 3) Galantamine 3 mg/kgi.p. caused a maximal 11.9 ± 2.7 ms prolongation of the corrected QT (QTc). Galantamine is a weak HERG blocker. This contributes to its mild QT-prolonging effect. Patients could be at risk of cardiac proarrhythmia during drug overdosage or interactions involving cytochrome 2D6 drug-metabolizing enzyme., (Copyright © 2012 Elsevier B.V. All rights reserved.)

Published
2012
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37. Metabolic syndrome potentiates the cardiac action potential-prolonging action of drugs: a possible 'anti-proarrhythmic' role for amlodipine.

Author

Caillier B, Pilote S, Patoine D, Levac X, Couture C, Daleau P, Simard C, and Drolet B

Subjects
Animals, Diet, High-Fat adverse effects, Guinea Pigs, Heart physiopathology, Male, Metabolic Syndrome etiology, Amlodipine pharmacology, Antihypertensive Agents pharmacology, Electrocardiography drug effects, Heart drug effects, Metabolic Syndrome drug therapy, Metabolic Syndrome physiopathology
Abstract

Type II diabetes was shown to prolong the QT interval on the ECG and to promote cardiac arrhythmias. This is not so clear for metabolic syndrome, a precursor state of type II diabetes. The objectives of the present study were to generate a guinea pig model of metabolic syndrome by long-term exposure to diabetogenic diets, and to evaluate the monophasic action potential duration (MAPD)-modulating effects of drugs in these animals. Male Hartley guinea pigs were fed with either the control, the High Fat High Sucrose (HFHS) or the High Fat High Fructose (HFHF) diet for 150 days. Evolution of weight, blood cholesterol, triglycerides, urea and glucose tolerance were regularly monitored. Histopathological evolution was also evaluated in target organs such as pancreas, heart, liver and kidneys. Ex vivo experiments using the Langendorff retroperfusion technique, isolated hearts from guinea pigs either fed with the control, the HFHS or the HFHF diet were exposed to dofetilide 20 nM (D), chromanol 293B 10 μM (C) and amlodipine 100 nM (A) in different drug combinations and monophasic action potential duration was measured at 90% repolarization (MAPD₉₀). Our data show that it is possible to generate a guinea pig model of metabolic syndrome by chronic exposure to diabetogenic diets. Minor histopathological abnormalities were observed, mainly in the pancreas and the liver. Metabolic syndrome potentiates the MAPD-prolonging actions of I(Kr)-blocking (dofetilide) and I(Ks)-blocking (chromanol 293B) drugs, an effect that is reversible upon administration of the calcium channel blocker amlodipine., (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Published
2012
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38. Prolongation of cardiac ventricular repolarization under paliperidone: how and how much?

Author

Vigneault P, Kaddar N, Bourgault S, Caillier B, Pilote S, Patoine D, Simard C, and Drolet B

Subjects
Animals, Antipsychotic Agents administration & dosage, CHO Cells, Cardiac Pacing, Artificial, Cricetinae, Cricetulus, ERG1 Potassium Channel, Ether-A-Go-Go Potassium Channels antagonists & inhibitors, Ether-A-Go-Go Potassium Channels genetics, Ether-A-Go-Go Potassium Channels metabolism, Guinea Pigs, HEK293 Cells, Humans, In Vitro Techniques, Isoxazoles administration & dosage, KCNQ1 Potassium Channel genetics, KCNQ1 Potassium Channel metabolism, Male, Paliperidone Palmitate, Patch-Clamp Techniques, Potassium Channels, Voltage-Gated genetics, Potassium Channels, Voltage-Gated metabolism, Pyrimidines administration & dosage, Recombinant Proteins antagonists & inhibitors, Recombinant Proteins metabolism, Antipsychotic Agents adverse effects, Dopamine Antagonists adverse effects, Heart drug effects, Isoxazoles adverse effects, Potassium Channel Blockers adverse effects, Pyrimidines adverse effects, Serotonin 5-HT2 Receptor Antagonists adverse effects, Ventricular Dysfunction chemically induced
Abstract

Introduction: Paliperidone (9-hydroxyrisperidone) is a second-generation antipsychotic. As observed with risperidone, QT interval prolongation was reported with paliperidone., Objective: The aim was to evaluate the effects of paliperidone on cardiac ventricular repolarization., Methods: (1) Patch-clamp experiments: Human ether-a-go-go-related gene (HERG)- or KCNQ1 + KCNE1-transfected cells were exposed to 0.1-100 μmol/L paliperidone (N = 39 cells, total) to assess the drug effect on HERG and KCNQ1 + KCNE1 currents. (2) Langendorff perfusion experiments: Hearts isolated from male Hartley guinea pigs (N = 9) were exposed to 0.1 μmol/L paliperidone to assess drug-induced prolongation of monophasic action potential duration measured at 90% repolarization. (3) In vivo cardiac telemetry experiments: Guinea pigs (N = 8) implanted with transmitters were injected a single intraperitoneal dose of 1 mg/kg of paliperidone, and 24-hour electrocardiogram recordings were made., Results: (1) The estimated concentration at which 50% of the maximal inhibitory effect is observed (IC(50)) for paliperidone on HERG current was 0.5276 μmol/L. In contrast, 1 μmol/L paliperidone had hardly any effect on KCNQ1 + KCNE1 current (4.0 ± 1.6% inhibition, N = 5 cells). (2) While pacing the hearts at cycle lengths of 150, 200, or 250 milliseconds, 0.1 μmol/L paliperidone prolonged monophasic action potential duration measured at 90% repolarization by, respectively, 6.1 ± 3.1, 9.8 ± 2.7, and 12.8 ± 2.7 milliseconds. (3) Paliperidone (1 mg/kg) intraperitoneal caused a maximal 15.7 ± 5.3-millisecond prolongation of QTc., Conclusions: Paliperidone prolongs the QT interval by blocking HERG current at clinically relevant concentrations and is potentially unsafe.

Published
2011
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39. Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity.

Author

Girard H, Lévesque E, Bellemare J, Journault K, Caillier B, and Guillemette C

Subjects
Animals, Base Sequence, Cell Line, DNA Primers genetics, DNA, Complementary genetics, Exons, Genetic Variation, Glucuronides metabolism, Humans, Macaca fascicularis, Models, Genetic, Pharmacogenetics, RNA, Messenger genetics, RNA, Messenger metabolism, Rats, Recombinant Proteins genetics, Recombinant Proteins metabolism, Tissue Distribution, Transfection, Alternative Splicing, Glucuronosyltransferase genetics, Glucuronosyltransferase metabolism
Abstract

Background: The gene UGT1 encodes phase II detoxification proteins involved in the elimination of small hydrophobic substances of both endogenous and exogenous origin. To date, nine functional UGT1A proteins are known to be produced from a single gene composed of alternative first exons shared with four common exons. Recently, a novel exon (referred to as exon 5b) was identified in the common shared region., Results: We now reveal a novel alternative splicing mechanism and demonstrate that the exon 5a and the new exon 5b are alternatively spliced, generating several variant mRNAs and up to nine previously unknown variant UGT1A proteins, referred to as isoforms 2 or i2. Isoform-specific RT-PCR analyses reveal that the alternatively spliced mRNAs are widely distributed in human tissues. Immunoreactive proteins at the predicted molecular weight of approximately 45 kDa were confirmed in microsomes of human tissues using antibodies against UGT1A1 and anti-UGT1A7/8/9/10. Functional enzyme assays demonstrate that i2 proteins containing exon 5b are enzymatically inactive. On the other hand, co-expression experiments of i2 of UGT1A1, UGT1A7, UGT1A8 and UGT1A9 with their classical isoform 1 homologs results in a significant repression (15 to 79%) of UGT1A&#95;i1-mediated drug metabolism., Conclusion: The UGT1A isoforms 2 act as negative modulators of their isoform 1 homologs in microsome preparations, revealing a new regulatory mechanism of the glucuronidation pathway. Findings further provide the first direct evidence of a novel alternative splicing mechanism at the 3' end of the UGT1 locus that further increases the number of proteins derived from this single gene.

Published
2007
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40. A pharmacogenomics study of the human estrogen glucuronosyltransferase UGT1A3.

Author

Caillier B, Lépine J, Tojcic J, Ménard V, Perusse L, Bélanger A, Barbier O, and Guillemette C

Subjects
5' Flanking Region, Base Sequence, Cell Line, DNA genetics, DNA metabolism, Estrone metabolism, Exons, Female, Genetic Variation, Haplotypes, Humans, Kinetics, Molecular Sequence Data, Mutagenesis, Site-Directed, Pharmacogenetics, Phenotype, Polymorphism, Genetic, Promoter Regions, Genetic, Protein Binding, Recombinant Proteins genetics, Recombinant Proteins metabolism, White People genetics, Glucuronosyltransferase genetics, Glucuronosyltransferase metabolism
Abstract

UGT1A3 is one of the most efficient at conjugating estrone, a precursor for biosynthesis of estradiol in peripheral tissues. We established the genetic mechanisms that might contribute to individual variation in UGT1A3 expression and activity. UGT1A3 first exon and 5'-flanking regions were sequenced in 249 Caucasians. We identified 17 polymorphisms, among them seven regulatory and 10 exonic polymorphisms with six leading to amino-acid changes. Luciferase reporter assays, site-directed mutagenesis and electrophoretic mobility shift assays using hepatoma HepG2 cells were carried out to show functionality of variant promoters. Reduced transcriptional activity was associated with all six variant promoters (two-fold; P<0.001). One of the potential mechanisms would involve the -148 T>C and -581 C>T variations that modulate gene function by affecting hepatocyte nuclear factor-1alpha and hepatocyte nuclear factor-4alpha binding, respectively. Then, estrone-conjugating activity was assessed with 11 heterologously expressed allozymes. Three phenotypes were observed; UGT1A3*1, *2 (WR, VA) and *3 (WR) with high intrinsic clearance values; UGT1A3*5 (QR, WR), *7 (FI), *9 (WR, ML), *10 (VA) and *11 (WR, VA and MI) had intermediate CLint (2X-10X lower vs. *1), whereas UGT1A3*4 (RW), *6 (WR, VA, MV) and *8 (AV) had low CLint (>10X lower vs. *1). Diplotype analyses indicate that 20.1% of individuals carry two alleles affecting UGT1A3 expression and/or activity. This study did not investigate genotype-phenotype association, but raise the possibility that genetically determined variation might contribute to variability in the inactivation of estrone by UGT1A3 and subsequent changes in lifetime exposure to estrogens potentially modifying risk of cancer.

Published
2007
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