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4. Investigating hormesis, aging, and neurodegeneration: From bench to clinics

Author

Calabrese Vittorio, Wenzel Uwe, Piccoli Tommaso, Jacob Ursula M., Nicolosi Lidia, Fazzolari Giovanni, Failla Gabriella, Fritsch Tilman, Osakabe Naomi, and Calabrese Edward J.

Subjects
antioxidants, hormesis, nrf2, mitochondrial medicine, c. elegans, longevity, Medicine
Abstract

Mitochondria-derived reactive oxygen species production at a moderate physiological level plays a fundamental role in the anti-aging signaling, due to their action as redox-active sensors for the maintenance of optimal mitochondrial balance between intracellular energy status and hormetic nutrients. Iron regulatory protein dysregulation, systematically increased iron levels, mitochondrial dysfunction, and the consequent oxidative stress are recognized to underlie the pathogenesis of multiple neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease. Central to their pathogenesis, Nrf2 signaling dysfunction occurs with disruption of metabolic homeostasis. We highlight the potential therapeutic importance of nutritional polyphenols as substantive regulators of the Nrf2 pathway. Here, we discuss the common mechanisms targeting the Nrf2/vitagene pathway, as novel therapeutic strategies to minimize consequences of oxidative stress and neuroinflammation, generally associated to cognitive dysfunction, and demonstrate its key neuroprotective and anti-neuroinflammatory properties, summarizing pharmacotherapeutic aspects relevant to brain pathophysiology.

Published
2024
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11. Hormesis determines lifespan

Author

Calabrese, Edward J., Nascarella, Marc, Pressman, Peter, Hayes, A. Wallace, Dhawan, Gaurav, Kapoor, Rachna, Calabrese, Vittorio, and Agathokleous, Evgenios

Published
2024
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19. Hormesis defines the limits of lifespan

Author

Calabrese, Edward J., Osakabe, Naomi, Di Paola, Rosanna, Siracusa, Rosalba, Fusco, Roberta, D’Amico, Ramona, Impellizzeri, Daniela, Cuzzocrea, Salvatore, Fritsch, Tilman, Abdelhameed, Ali S., Wenzel, Uwe, Franceschi, Claudio, and Calabrese, Vittorio

Published
2023
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44. Food for Brain Health

Author

Calabrese, Vittorio, Trovato, Angela, Scuto, Maria, Ontario, Maria Laura, Rampulla, Francesco, Zimbone, Vincenzo, La Mantia, Ignazio, Greco, Valentina, Sciuto, Sebastiano, Crea, Roberto, Calabrese, Edward J., Dionisio, Giuseppe, Rattan, Suresh I.S., Series Editor, Barbagallo, Mario, Editorial Board Member, Çakatay, Ufuk, Editorial Board Member, Fraifeld, Vadim E., Editorial Board Member, Fülöp, Tamàs, Editorial Board Member, Gruber, Jan, Editorial Board Member, Jin, Kunlin, Editorial Board Member, Kaul, Sunil, Editorial Board Member, Kaur, Gurcharan, Editorial Board Member, Le Bourg, Eric, Editorial Board Member, Lopez Lluch, Guillermo, Editorial Board Member, Moskalev, Alexey, Editorial Board Member, Nehlin, Jan, Editorial Board Member, Pawelec, Graham, Editorial Board Member, Rizvi, Syed Ibrahim, Editorial Board Member, Sholl, Jonathan, Editorial Board Member, Stambler, Ilia, Editorial Board Member, Szczerbińska, Katarzyna, Editorial Board Member, Trougakos, Ioannis P., Editorial Board Member, Wadhwa, Renu, Editorial Board Member, Wnuk, Maciej, Editorial Board Member, and Rattan, Suresh I. S., editor

Published
2021
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