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12. The new Italian SIDAPA Baseline Series for patch testing (2023): an update according to the new regulatory pathway for contact allergens

Author

Luca, S, Leonardo, B, S, C, Fortina Anna, B, Francesca, C, Monica, C, Alessandro, B, Rosella, G, Ilaria, T, M, F, Andrea, B, Fabrizio, G, Emanuela, M, Maddalena, N, Lucia Mario, D, Cataldo, P, Luigi, B, Paolo, R, Caterina, F, Marta, T, Rossella, M, Giuseppe, A, Katharina, H, Abategiovanni, L, Albertazzi, D, Ali Biglu Marash, S, Amendolagine, G, Angelini, G, Annunziata, A, Assalve, D, Ayala, F, Babino, G, Barruscotti, S, Battista, T, Berta, M, Biondi, F, Boccaletti, V, Bonamonte, D, Bruni, F, Buffon, R, Caccavale, S, Calabrese, L, Calzavara Pinton, P, Camela, E, Carugno, A, Casciola, G, Cecchini, E, Cristaudo, A, D'Agostino, M, Damiani, G, Danese, P, Dattola, A, DE Salvo, V, Errichetti, E, Esposito, G, Esposito, M, Fantini, C, Fontana, E, Fornaro, L, Adina Frasin, L, Galeotti, T, Gasparini, G, Genco, L, Gravante, M, Guastaferro, D, Guerrasio, G, Guerriero, L, Lauro, W, Lucagnano, G, Malatesta, N, Desmond Mandel, V, Marano, L, Marino, V, Martora, F, Menna, L, Miano, C, Miccio, L, Michelerio, A, Milanesi, N, Monfrecola, G, Motolese, A, Nocerino, M, Noto, M, Ornielli, M, Pacifico, A, Papini, M, Pasolini, G, Penchini, L, Perazzolli, G, Peserico, A, Piccolo, V, Pigatto, P, Potestio, L, Pugliese, A, Recalcati, S, Rivetti, N, Rossi, M, Russo, F, Russo, T, Schena, D, Sensini, C, Tesauri, D, Marco Tomassini, G, Ventura, V, Venturini, M, Vezzoli, P, Vincenzi, C, Stingeni Luca, Bianchi Leonardo, Caroppo Elena S, Belloni Fortina Anna, Caroppo Francesca, Corazza Monica, Borghi Alessandro, Gallo Rosella, Trave Ilaria, Ferrucci Silvia M, Beretta Andrea, Guarneri Fabrizio, Martina Emanuela, Napolitano Maddalena, De Lucia Mario, Patruno Cataldo, Bennardo Luigi, Romita Paolo, Foti Caterina, Tramontana Marta, Marietti Rossella, Argenziano Giuseppe, Hansel Katharina, Luisa Abategiovanni, Donatella Albertazzi, Samane Ali Biglu Marash, Graziana Amendolagine, Gianni Angelini, Alberto Annunziata, Danilo Assalve, Fabio Ayala, Graziella Babino, Stefania Barruscotti, Teresa Battista, Mauro Berta, Filippo Biondi, Valeria Boccaletti, Domenico Bonamonte, Francesca Bruni, Rosana Buffon, Stefano Caccavale, Laura Calabrese, Piergiacomo Calzavara Pinton, Elisa Camela, Andrea Carugno, Gabriele Casciola, Elisa Cecchini, Antonio Cristaudo, Michela D'Agostino, Giovanni Damiani, Pietro Danese, Annunziata Dattola, Vincenzo DE Salvo, Enzo Errichetti, Gianluca Esposito, Maria Esposito, Carolina Fantini, Elena Fontana, Luigi Fornaro, Lucretia Adina Frasin, Tommaso Galeotti, Giulia Gasparini, Lucia Genco, Massimo Gravante, Donatella Guastaferro, Gianluca Guerrasio, Luigi Guerriero, Wanda Lauro, Gioacchino Lucagnano, Nicolò Malatesta, Victor Desmond Mandel, Laura Marano, Vincenzo Marino, Fabrizio Martora, Luca Menna, Chiara Miano, Laura Miccio, Andrea Michelerio, Nicola Milanesi, Giuseppe Monfrecola, Alberico Motolese, Mariateresa Nocerino, Matteo Noto, Matteo Ornielli, Alessia Pacifico, Manuela Papini, Giorgio Pasolini, Luca Penchini, Gabriele Perazzolli, Andrea Peserico, Vincenzo Piccolo, Paolo Pigatto, Luca Potestio, Antonio Pugliese, Sebastiano Recalcati, Nicolò Rivetti, Mariateresa Rossi, Filomena Russo, Teresa Russo, Donatella Schena, Chiara Sensini, David Tesauri, Gian Marco Tomassini, Virginia Ventura, Marina Venturini, Pamela Vezzoli, Colombina Vincenzi, Luca, S, Leonardo, B, S, C, Fortina Anna, B, Francesca, C, Monica, C, Alessandro, B, Rosella, G, Ilaria, T, M, F, Andrea, B, Fabrizio, G, Emanuela, M, Maddalena, N, Lucia Mario, D, Cataldo, P, Luigi, B, Paolo, R, Caterina, F, Marta, T, Rossella, M, Giuseppe, A, Katharina, H, Abategiovanni, L, Albertazzi, D, Ali Biglu Marash, S, Amendolagine, G, Angelini, G, Annunziata, A, Assalve, D, Ayala, F, Babino, G, Barruscotti, S, Battista, T, Berta, M, Biondi, F, Boccaletti, V, Bonamonte, D, Bruni, F, Buffon, R, Caccavale, S, Calabrese, L, Calzavara Pinton, P, Camela, E, Carugno, A, Casciola, G, Cecchini, E, Cristaudo, A, D'Agostino, M, Damiani, G, Danese, P, Dattola, A, DE Salvo, V, Errichetti, E, Esposito, G, Esposito, M, Fantini, C, Fontana, E, Fornaro, L, Adina Frasin, L, Galeotti, T, Gasparini, G, Genco, L, Gravante, M, Guastaferro, D, Guerrasio, G, Guerriero, L, Lauro, W, Lucagnano, G, Malatesta, N, Desmond Mandel, V, Marano, L, Marino, V, Martora, F, Menna, L, Miano, C, Miccio, L, Michelerio, A, Milanesi, N, Monfrecola, G, Motolese, A, Nocerino, M, Noto, M, Ornielli, M, Pacifico, A, Papini, M, Pasolini, G, Penchini, L, Perazzolli, G, Peserico, A, Piccolo, V, Pigatto, P, Potestio, L, Pugliese, A, Recalcati, S, Rivetti, N, Rossi, M, Russo, F, Russo, T, Schena, D, Sensini, C, Tesauri, D, Marco Tomassini, G, Ventura, V, Venturini, M, Vezzoli, P, Vincenzi, C, Stingeni Luca, Bianchi Leonardo, Caroppo Elena S, Belloni Fortina Anna, Caroppo Francesca, Corazza Monica, Borghi Alessandro, Gallo Rosella, Trave Ilaria, Ferrucci Silvia M, Beretta Andrea, Guarneri Fabrizio, Martina Emanuela, Napolitano Maddalena, De Lucia Mario, Patruno Cataldo, Bennardo Luigi, Romita Paolo, Foti Caterina, Tramontana Marta, Marietti Rossella, Argenziano Giuseppe, Hansel Katharina, Luisa Abategiovanni, Donatella Albertazzi, Samane Ali Biglu Marash, Graziana Amendolagine, Gianni Angelini, Alberto Annunziata, Danilo Assalve, Fabio Ayala, Graziella Babino, Stefania Barruscotti, Teresa Battista, Mauro Berta, Filippo Biondi, Valeria Boccaletti, Domenico Bonamonte, Francesca Bruni, Rosana Buffon, Stefano Caccavale, Laura Calabrese, Piergiacomo Calzavara Pinton, Elisa Camela, Andrea Carugno, Gabriele Casciola, Elisa Cecchini, Antonio Cristaudo, Michela D'Agostino, Giovanni Damiani, Pietro Danese, Annunziata Dattola, Vincenzo DE Salvo, Enzo Errichetti, Gianluca Esposito, Maria Esposito, Carolina Fantini, Elena Fontana, Luigi Fornaro, Lucretia Adina Frasin, Tommaso Galeotti, Giulia Gasparini, Lucia Genco, Massimo Gravante, Donatella Guastaferro, Gianluca Guerrasio, Luigi Guerriero, Wanda Lauro, Gioacchino Lucagnano, Nicolò Malatesta, Victor Desmond Mandel, Laura Marano, Vincenzo Marino, Fabrizio Martora, Luca Menna, Chiara Miano, Laura Miccio, Andrea Michelerio, Nicola Milanesi, Giuseppe Monfrecola, Alberico Motolese, Mariateresa Nocerino, Matteo Noto, Matteo Ornielli, Alessia Pacifico, Manuela Papini, Giorgio Pasolini, Luca Penchini, Gabriele Perazzolli, Andrea Peserico, Vincenzo Piccolo, Paolo Pigatto, Luca Potestio, Antonio Pugliese, Sebastiano Recalcati, Nicolò Rivetti, Mariateresa Rossi, Filomena Russo, Teresa Russo, Donatella Schena, Chiara Sensini, David Tesauri, Gian Marco Tomassini, Virginia Ventura, Marina Venturini, Pamela Vezzoli, and Colombina Vincenzi

Abstract

Allergic contact dermatitis (ACD) is a common inflammatory skin disease caused by delayed hypersensitivity to chemical and biotic contact allergens. ACD significantly affects the patients' quality of life negatively impacting both occupational and non-occupational settings. Patch testing is the gold standard diagnostic in vivo test to precise the ACD etiology and to correctly perform prevention. According to the Italian Medicines Agency (AIFA) legislative decree no. 178 of 29th May 1991, allergens are defined as medicines and therefore they are subject to strict regulation. In 2017, AIFA (decree no. 2130/2017) started a procedure to regulate contact allergens on the Italian market and actually the contact allergens temporarily authorized are reported in AIFA decree no. 98/2022, valid until November 2023. The availability on the market of contact allergens to diagnose ACD and continuous updating on the basis of new epidemiological trends are mandatory, jointly with the continuous update of the baseline and integrative series for patch testing. For this reason, the scientific community represented in Italy by the Skin Allergies Study Group of SIDeMaST (Italian Society of Dermatology and Venereology) and SIDAPA (Italian Society of Allergological, Occupational and Environmental Dermatology) are constantly working, in close relationship with the European scientific communities with large expertise in this important sector of the modern Dermatology. Herein, we report the setting up of regulatory legislation by AIFA and the new Italian Adult Baseline Series for patch testing.

Published
2024

13. Drug survival of biologics and non-biologics in patients affected by palmoplantar psoriasis: a “real-world”, mono-center experience

Author

Caldarola, Giacomo, Falco, Gennaro Marco, Calabrese, Laura, D'Amore, Antonio, Chiricozzi, Andrea, Mariani, Marco, Palmisano, Gerardo, De Simone, Clara, Peris, Ketty, Caldarola G. (ORCID:0000-0002-8837-9232), Falco G. M., Calabrese L., D'Amore A., Chiricozzi A. (ORCID:0000-0002-6739-0387), Mariani M., Palmisano G., De Simone C. (ORCID:0000-0002-0898-0045), Peris K. (ORCID:0000-0002-5237-0463), Caldarola, Giacomo, Falco, Gennaro Marco, Calabrese, Laura, D'Amore, Antonio, Chiricozzi, Andrea, Mariani, Marco, Palmisano, Gerardo, De Simone, Clara, Peris, Ketty, Caldarola G. (ORCID:0000-0002-8837-9232), Falco G. M., Calabrese L., D'Amore A., Chiricozzi A. (ORCID:0000-0002-6739-0387), Mariani M., Palmisano G., De Simone C. (ORCID:0000-0002-0898-0045), and Peris K. (ORCID:0000-0002-5237-0463)

Abstract

Background: Data on the treatment of palmoplantar psoriasis (PP) are very limited as these patients are often excluded from clinical trials. Moreover, this form of psoriasis is often resistant to treatment, making its clinical management complex. Methods: Primary endpoint was to evaluate the clinical and demographic characteristics and the drug survival of both biological and non-biological drugs in a population affected by PP. Secondary endpoint was to highlight any differences between the hyperkeratotic and pustular variant. We analyzed data from 233 psoriasis patients with palmoplantar involvement, with or without chronic plaque psoriasis. We performed a drug-survival analysis with the aid of Kaplan-Meier survival and a multivariate analysis to highlight the influence of certain variables on treatment persistence using a Cox regression model. Results: The drug-survival analysis revealed that biologic drugs compared to non-biologic drugs are associated with a higher persistence in treatment (59.73 vs. 43.56%); in particular, anti-IL23 drugs were found to be the drugs with the best drug-survival overall (67.94% of patients at 60 months are still on these drugs). Furthermore, our multivariate analysis shows that when compared with biological drugs, non-biological drugs are associated with an increased risk of treatment discontinuation (HR = 1.95 [95% CI: 1.41-2.68], P = 0.001). Conclusions: Our study confirms the difficulty of treating PP and shows that biologic drugs are associated with longer persistence in treatment than non-biologics in both PP's variants, not because of their higher effectiveness but because of their better safety profile.

Published
2024

15. Profil de tolérance de l’upadacitinib chez des patients atteints de polyarthrite rhumatoïde après une durée d’exposition pouvant aller jusqu’à 6,5 ans

Author

Cohen, S.B., primary, Van Vollenhoven, R., additional, Curtis, J., additional, Calabrese, L., additional, Zerbini, C., additional, Tanaka, Y., additional, Bessette, L., additional, Richez, C., additional, Strengholt, S., additional, Coombs, D., additional, Khan, N., additional, Gara, A., additional, and Burmester, G.R., additional

Published
2023
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19. Contributors

Author

Accornero, F., primary, Aggelis, D.G., additional, Calabrese, L., additional, Carpinteri, A., additional, Deraemaeker, A., additional, Dumoulin, C., additional, ElBatanouny, M., additional, Fukuyama, T., additional, Grondinn, F., additional, Karaiskos, G., additional, Kawasaki, Y., additional, Lacidogna, G., additional, Linzer, L., additional, Loukili, A., additional, Matikas, T.E., additional, Mhamdi, L., additional, Mpalaskas, A.C., additional, Niccolini, G., additional, Ohno, Kentaro, additional, Okamoto, T., additional, Oshita, H., additional, Piana, G., additional, Prasad, B.K. Raghu, additional, Proverbio, E., additional, Sagar, R. Vidya, additional, Saliba, J., additional, Schumacher, T., additional, Shimamoto, Y., additional, Singh, R.K., additional, Suzuki, T., additional, Takeda, Mitsuhiro, additional, and Ziehl, P., additional

Published
2021
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22. Flax–Glass Fiber Reinforced Hybrid Composites Exposed to a Salt-Fog/Dry Cycle: A Simplified Approach to Predict Their Performance Recovery

Author

Calabrese L., Badagliacco D., Sanfilippo C., Fiore V., Calabrese L., Badagliacco D., Sanfilippo C., and Fiore V.

Subjects
Settore ING-IND/22 - Scienza E Tecnologia Dei Materiali, environmental degradation, flax fibers, forecasting modeling, hybrid composites, mechanical properties, moisture sorption
Abstract

Despite natural fibers gaining significant attention in recent decades, their limited performance and poor durability under humid environments cannot allow them to fully replace their synthetic counterparts as reinforcement for structural composites. In such a context, this paper aims to investigate how exposure to a humid/dry cycle affects the mechanical response of epoxy laminates reinforced with flax and glass fibers. In particular, the main goal is to assess the performance evolution of a glass–flax hybridized stacking sequence in comparison with the full glass and flax fiber reinforced composites. To this end, the investigated composites were first exposed to salt-fog for 15 or 30 days and then to dry conditions (i.e., 50% R.H. and 23 °C) for up to 21 days. The presence of glass fibers in the stacking sequence significantly stabilizes the mechanical performance of composites during the humid/dry cycle. Indeed, hybridization of inner flax laminae with outer glass ones, acting as a protective shield, hinders the composite degradation due to the humid phase also promoting performance recovery during the dry phase. Hence, this work showed that a tailored hybridization of natural fibers with glass fibers represents a suitable approach to extend the service-life of natural fiber reinforced composites exposed to discontinuous humid conditions, thus allowing their employment in practical indoor and outdoor applications. Finally, a simplified theoretical pseudo-second-order model that aimed to forecast the performance recovery shown by composites was proposed and experimentally validated, highlighting good agreement with the experimental data.

Published
2023

34. List of Contributors

Author

Aggarwal, Geeta, primary, Ahmad, Mudasir, additional, Ahmad, Suhail, additional, Amorim, M. Teresa P., additional, Andronescu, Ecaterina, additional, Barreiro, Maria Filomena, additional, Batra, Sonali, additional, Brar, Amandeep, additional, Calabrese, L., additional, Campos-Cruz, Juan-Ramòn, additional, Chaturvedi, Thakur Prasad, additional, Costache, Marieta, additional, Dias, Madalena Maria, additional, Fabiano, F., additional, Felgueiras, Helena P., additional, Ficai, Anton, additional, Galateanu, Bianca, additional, Grumezescu, Alexandru Mihai, additional, Han, Sung Soo, additional, Hudita, Ariana, additional, Ikram, Saiqa, additional, Kumar, Anuj, additional, Kumar, Ashish, additional, Kumar, Manish, additional, Lopes, Jose Carlos, additional, Maman, Paramjot, additional, Manzoor, Kaiser, additional, Nagpal, Manju, additional, Oprea, Alexandra Elena, additional, Pandey, Lalit M., additional, Pareek, Nidhi, additional, Popescu, Roxana C., additional, Prakash, Rajiv, additional, Proverbio, E., additional, Rangel-Vàzquez, Norma-Aurea, additional, Rangel-Vàzquez, Ricardo, additional, Ruphuy, Gabriela, additional, Saharan, Lokesh, additional, Saxena, Varun, additional, Sharma, Sumit, additional, Shukla, Ishani, additional, Tadesse, Yonas, additional, Vivek, Rajul, additional, and Vivekanand, V., additional

Published
2019
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35. Overview of Atopic Dermatitis in Different Ethnic Groups

Author

Chiricozzi, Andrea, Maurelli, M., Calabrese, Laura, Peris, Ketty, Girolomoni, G., Chiricozzi A. (ORCID:0000-0002-6739-0387), Calabrese L., Peris K. (ORCID:0000-0002-5237-0463), Chiricozzi, Andrea, Maurelli, M., Calabrese, Laura, Peris, Ketty, Girolomoni, G., Chiricozzi A. (ORCID:0000-0002-6739-0387), Calabrese L., and Peris K. (ORCID:0000-0002-5237-0463)

Abstract

Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a high prevalence worldwide, including countries from Asia, Africa, and Latin America, and in different ethnic groups. In recent years, more attention has been placed on the heterogeneity of AD associated with multiple factors, including a patient’s ethnic background, resulting in an increasing body of clinical, genetic, epidemiologic, and immune-phenotypic evidence that delineates differences in AD among racial groups. Filaggrin (FLG) mutations, the strongest genetic risk factor for the development of AD, are detected in up to 50% of European and 27% of Asian AD patients, but very rarely in Africans. Th2 hyperactivation is a common attribute of all ethnic groups, though the Asian endotype of AD is also characterized by an increased Th17-mediated signal, whereas African Americans show a strong Th2/Th22 signature and an absence of Th1/Th17 skewing. In addition, the ethnic heterogeneity of AD may hold important therapeutic implications as a patient’s genetic predisposition may affect treatment response and, thereby, a tailored strategy that better targets the dominant immunologic pathways in each ethnic subgroup may be envisaged. Nevertheless, white patients with AD represent the largest ethnicity enrolled and tested in clinical trials and the most treated in a real-world setting, limiting investigations about safety and efficacy across different ethnicities. The purpose of this review is to describe the heterogeneity in the pathophysiology of AD across ethnicities and its potential therapeutic implications.

Published
2023

41. BURNING MOUTH DISEASE, MODERN TREATMENT AND CLINICAL MANAGEMENT: A NARRATIVE REVIEW

Author

Luciani F, Papa E, Leggeri A, Calabrese C, Condo ' R, and Calabrese L

Abstract

PURPOSE: The purpose of this review was to investigate the current and modern therapy approach of BMD (burning mouth disease) also referred as BMS (burning mouth syndrome), in order to have a better comprehension for the best and most successful way of treatment and management for this pathology. A literature research was carried outMATERIALS & METHODS: mainly using online sources, Pubmed database, and paper sources (specialized books). articles published over the last years have been rstly examined. Systematic reviews, narrative reviews, mini reviews and meta-analysis were primarily selected. If a subject matter appeared to have few or no such sources, articles based on case reports were also considered. Finally, 20 sources have been considered eligible for theRESULTS: purpose of the review, 19 scientic articles and 1 specialized book were selected. Clonazepam, capsaicin and Vortioxetine areCONCLUSIONS: currently the most widely used and known drugs even if further studies are needed especially in the case of Vortioxetine and selective serotonin reuptake inhibitors.

Published
2022

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