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437 results on '"Calatroni, Agustin"'

1. A pediatric randomized, controlled trial of German cockroach subcutaneous immunotherapy

Author

Zoratti, Edward, Wood, Robert, Pomés, Anna, Da Silva Antunes, Ricardo, Altman, Matthew C., Benson, Basilin, Wheatley, Lisa M., Cho, Kate, Calatroni, Agustin, Little, Frederic F., Pongracic, J., Makhija, Melanie, Khurana Hershey, Gurjit K., Sherenian, Michael G., Rivera-Spoljaric, Katherine, Stokes, Jeffrey R., Gill, Michelle A., Gruchalla, Rebecca S., Chambliss, Jeffrey, Liu, Andrew H., Kattan, Meyer, Busse, Paula J., Bacharier, Leonard B., Sheehan, William, Kim, Haejin., Glesner, Jill, Gergen, Peter J., Togias, Alkis, Baucom, Jessica L., Visness, Cynthia M., Sette, Alessandro, Busse, William W., and Jackson, Daniel J.

Published
2024
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3. Clinical and molecular analysis of longitudinal rhinitis phenotypes in an urban birth cohort

Author

Ramratnam, Sima K., Johnson, Molly, Visness, Cynthia M., Calatroni, Agustin, Altman, Mathew C., Janczyk, Tomasz, McCauley, Kathryn E., Schachtschneider, Claire, Fujimura, Kei E., Fadrosh, Douglas W., Lynch, Susan V., Bacharier, Leonard B., O'Connor, George T., Sandel, Megan T., Kattan, Meyer, Wood, Robert A., Gergen, Peter J., Jackson, Daniel J., Togias, Alkis, and Gern, James E.

Published
2024
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5. Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial

Author

Nakatsuji, Teruaki, Hata, Tissa R, Tong, Yun, Cheng, Joyce Y, Shafiq, Faiza, Butcher, Anna M, Salem, Secilia S, Brinton, Samantha L, Rudman Spergel, Amanda K, Johnson, Keli, Jepson, Brett, Calatroni, Agustin, David, Gloria, Ramirez-Gama, Marco, Taylor, Patricia, Leung, Donald YM, and Gallo, Richard L

Subjects
Clinical Research, Emerging Infectious Diseases, Infectious Diseases, Eczema / Atopic Dermatitis, Clinical Trials and Supportive Activities, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Skin, Administration, Topical, Adolescent, Adult, Aged, Aged, 80 and over, Animals, Bacterial Proteins, Bacteriocins, Colony Count, Microbial, Dermatitis, Atopic, Humans, Inflammation, Mice, Inbred BALB C, Microbial Sensitivity Tests, Microbial Viability, Middle Aged, Peptides, Cyclic, Reproducibility of Results, Staphylococcal Infections, Staphylococcus aureus, Staphylococcus hominis, Transcription, Genetic, Treatment Outcome, Virulence Factors, Young Adult, Medical and Health Sciences, Immunology
Abstract

Staphylococcus aureus colonizes patients with atopic dermatitis (AD) and exacerbates disease by promoting inflammation. The present study investigated the safety and mechanisms of action of Staphylococcus hominis A9 (ShA9), a bacterium isolated from healthy human skin, as a topical therapy for AD. ShA9 killed S. aureus on the skin of mice and inhibited expression of a toxin from S. aureus (psmα) that promotes inflammation. A first-in-human, phase 1, double-blinded, randomized 1-week trial of topical ShA9 or vehicle on the forearm skin of 54 adults with S. aureus-positive AD (NCT03151148) met its primary endpoint of safety, and participants receiving ShA9 had fewer adverse events associated with AD. Eczema severity was not significantly different when evaluated in all participants treated with ShA9 but a significant decrease in S. aureus and increased ShA9 DNA were seen and met secondary endpoints. Some S. aureus strains on participants were not directly killed by ShA9, but expression of mRNA for psmα was inhibited in all strains. Improvement in local eczema severity was suggested by post-hoc analysis of participants with S. aureus directly killed by ShA9. These observations demonstrate the safety and potential benefits of bacteriotherapy for AD.

Published
2021

6. Rapid reduction in Staphylococcus aureus in atopic dermatitis subjects following dupilumab treatment

Author

Simpson, Eric L., Schlievert, Patrick M., Yoshida, Takeshi, Lussier, Stephanie, Boguniewicz, Mark, Hata, Tissa, Fuxench, Zelma, De Benedetto, Anna, Ong, Peck Y., Ko, Justin, Calatroni, Agustin, Rudman Spergel, Amanda K., Plaut, Marshall, Quataert, Sally A., Kilgore, Samuel H., Peterson, Liam, Gill, Ann L., David, Gloria, Mosmann, Tim, Gill, Steven R., Leung, Donald Y.M., and Beck, Lisa A.

Published
2023
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8. The SunBEAm birth cohort: Protocol design

Author

Keet, Corinne, Sicherer, Scott H., Bunyavanich, Supinda, Visness, Cynthia, Fulkerson, Patricia C., Togias, Alkis, Davidson, Wendy, Perry, Susan, Hamrah, Sanaz, Calatroni, Agustin, Robinson, Katina, Dunaway, Lars, Davis, Carla M., Anvari, Sara, Leong-Kee, Susan M., Hershey, Gurjit Khurana, DeFranco, Emily, Devonshire, Ashley, Kim, Haejin, Joseph, Christine, Davidson, Brent, Strong, Noel K., Tsuang, Angela J., Groetch, Marion, Wang, Julie, Dantzer, Jennifer, Mudd, Kim, Aina, Abimbola, Shreffler, Wayne, Yuan, Qian, Simmons, Virginia, Leung, Donald Y.M., Hui-Beckman, Jessica, Ramos, Jania Arcia, Chinthrajah, Sharon, Winn, Virginia, Sindher, Tina, Jones, Stacie M., Manning, Nirvana A., Scurlock, Amy M., Kim, Edwin, Stuebe, Alison, Gern, James E., Singh, Anne Marie, Krupp, Jennifer, and Wood, Robert A.

Published
2023
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9. Associations between outdoor air pollutants and non-viral asthma exacerbations and airway inflammatory responses in children and adolescents living in urban areas in the USA: a retrospective secondary analysis

Author

Altman, Matthew C, Kattan, Meyer, O'Connor, George T, Murphy, Ryan C, Whalen, Elizabeth, LeBeau, Petra, Calatroni, Agustin, Gill, Michelle A, Gruchalla, Rebecca S, Liu, Andrew H, Lovinsky-Desir, Stephanie, Pongracic, Jacqueline A, Kercsmar, Carolyn M, Khurana Hershey, Gurjit K, Zoratti, Edward M, Teach, Stephen J, Bacharier, Leonard B, Wheatley, Lisa M, Sigelman, Steve M, Gergen, Peter J, Togias, Alkis, Busse, William W, Gern, James E, and Jackson, Daniel J

Published
2023
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10. Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma

Author

McCauley, Kathryn, Durack, Juliana, Valladares, Ricardo, Fadrosh, Douglas W, Lin, Din L, Calatroni, Agustin, LeBeau, Petra K, Tran, Hoang T, Fujimura, Kei E, LaMere, Brandon, Merana, Geil, Lynch, Kole, Cohen, Robyn T, Pongracic, Jacqueline, Hershey, Gurjit K Khurana, Kercsmar, Carolyn M, Gill, Michelle, Liu, Andrew H, Kim, Haejin, Kattan, Meyer, Teach, Stephen J, Togias, Alkis, Boushey, Homer A, Gern, James E, Jackson, Daniel J, Lynch, Susan V, and Consortium, Institute of Allergy and Infectious Diseases–sponsored Inner-City Asthma

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Asthma, Clinical Research, Pediatric, Infectious Diseases, 2.1 Biological and endogenous factors, Aetiology, 2.2 Factors relating to the physical environment, Infection, Respiratory, A549 Cells, Adolescent, Cell Death, Child, Disease Progression, Eosinophils, Female, Humans, Infant, Inflammation, Male, Microbiota, Nasal Mucosa, RNA, Ribosomal, 16S, Respiratory System, Respiratory Tract Infections, Moraxella species, Staphylococcus species, 16S rRNA, airway, asthma, exacerbation, rhinovirus, National Institute of Allergy and Infectious Diseases–sponsored Inner-City Asthma Consortium, Immunology, Allergy
Abstract

BackgroundIn infants, distinct nasopharyngeal bacterial microbiotas differentially associate with the incidence and severity of acute respiratory tract infection and childhood asthma development.ObjectiveWe hypothesized that distinct nasal airway microbiota structures also exist in children with asthma and relate to clinical outcomes.MethodsNasal secretion samples (n = 3122) collected after randomization during the fall season from children with asthma (6-17 years, n = 413) enrolled in a trial of omalizumab (anti-IgE) underwent 16S rRNA profiling. Statistical analyses with exacerbation as the primary outcome and rhinovirus infection and respiratory illnesses as secondary outcomes were performed. Using A549 epithelial cells, we assessed nasal isolates of Moraxella, Staphylococcus, and Corynebacterium species for their capacity to induce epithelial damage and inflammatory responses.ResultsSix nasal airway microbiota assemblages, each dominated by Moraxella, Staphylococcus, Corynebacterium, Streptococcus, Alloiococcus, or Haemophilus species, were observed. Moraxella and Staphylococcus species-dominated microbiotas were most frequently detected and exhibited temporal stability. Nasal microbiotas dominated by Moraxella species were associated with increased exacerbation risk and eosinophil activation. Staphylococcus or Corynebacterium species-dominated microbiotas were associated with reduced respiratory illness and exacerbation events, whereas Streptococcus species-dominated assemblages increased the risk of rhinovirus infection. Nasal microbiota composition remained relatively stable despite viral infection or exacerbation; only a few taxa belonging to the dominant genera exhibited relative abundance fluctuations during these events. In vitro, Moraxella catarrhalis induced significantly greater epithelial damage and inflammatory cytokine expression (IL-33 and IL-8) compared with other dominant nasal bacterial isolates tested.ConclusionDistinct nasal airway microbiotas of children with asthma relate to the likelihood of exacerbation, rhinovirus infection, and respiratory illnesses during the fall season.

Published
2019

11. Mepolizumab for urban children with exacerbation-prone eosinophilic asthma in the USA (MUPPITS-2): a randomised, double-blind, placebo-controlled, parallel-group trial

Author

Jackson, Daniel J, Bacharier, Leonard B, Gergen, Peter J, Gagalis, Lisa, Calatroni, Agustin, Wellford, Stephanie, Gill, Michelle A, Stokes, Jeffrey, Liu, Andrew H, Gruchalla, Rebecca S, Cohen, Robyn T, Makhija, Melanie, Khurana Hershey, Gurjit K, O'Connor, George T, Pongracic, Jacqueline A, Sherenian, Michael G, Rivera-Spoljaric, Katherine, Zoratti, Edward M, Teach, Stephen J, Kattan, Meyer, Dutmer, Cullen M, Kim, Haejin, Lamm, Carin, Sheehan, William J, Segnitz, R Max, Dill-McFarland, Kimberly A, Visness, Cynthia M, Becker, Patrice M, Gern, James E, Sorkness, Christine A, Busse, William W, and Altman, Matthew C

Published
2022
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12. Human Epidemiology and Response to SARS-CoV-2 (HEROS): objectives, design, and enrollment results of a 12-city remote observational surveillance study of households with children, using direct-to-participant methods.

Author

Fulkerson, Patricia C, Lussier, Stephanie J, Bendixsen, Casper G, Castina, Sharon M, Gebretsadik, Tebeb, Marlin, Jessica S, Russell, Patty B, Seibold, Max A, Everman, Jamie L, Moore, Camille M, Snyder, Brittney M, Thompson, Kathy, Tregoning, George S, Wellford, Stephanie, Arbes, Samuel J, Bacharier, Leonard B, Calatroni, Agustin, Camargo Jr, Carlos A, Dupont, William D, and Furuta, Glenn T

Subjects
PUBLIC health surveillance, RISK assessment, RESEARCH funding, FAMILIES, ALLERGIES, LONGITUDINAL method, TELEMEDICINE, GENE expression profiling, COVID-19, SARS-CoV-2, ASTHMA, MEDICAL referrals
Abstract

The Human Epidemiology and Response to SARS-CoV-2 (HEROS) Study is a prospective, multicity, 6-month incidence study conducted from May 2020 to February 2021. The objectives were to identify risk factors for SARS-CoV-2 infection and household transmission among children and people with asthma and allergic diseases, and to use the host nasal transcriptome sampled longitudinally to understand infection risk and sequelae at the molecular level. To overcome challenges of clinical study implementation due to the coronavirus pandemic, this surveillance study used direct-to-participant methods to remotely enroll and prospectively follow eligible children who are participants in other National Institutes of Health–funded pediatric research studies and their household members. Households participated in weekly surveys and biweekly nasal sampling regardless of symptoms. The aim of this report is to widely share the methods and study instruments and to describe the rationale, design, execution, logistics, and characteristics of a large, observational, household-based, remote cohort study of SARS-CoV-2 infection and transmission in households with children. The study enrolled a total of 5598 individuals, including 1913 principal participants (children), 1913 primary caregivers, 729 secondary caregivers, and 1043 other household children. This study was successfully implemented without necessitating any in-person research visits and provides an approach for rapid execution of clinical research. Trial registration: ClinicalTrials.gov. Identifier: NCT04375761 [ABSTRACT FROM AUTHOR]

Published
2024
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15. Viral and non‐viral episodes of wheezing in early life and the development of asthma and respiratory phenotypes among urban children.

Author

Havens, Tara N., LeBeau, Petra, Calatroni, Agustin, Gern, James E., O'Connor, George T., Wood, Robert A., Lamm, Carin, Krouse, Rebecca Z., Visness, Cynthia M., Gergen, Peter J., Jackson, Daniel J., and Bacharier, Leonard B.

Subjects
WHEEZE, ASTHMATICS, PHENOTYPES, ASTHMA in children, ASTHMA, DIAGNOSTIC use of polymerase chain reaction
Abstract

Background: Viral wheezing is an important risk factor for asthma, which comprises several respiratory phenotypes. We sought to understand if the etiology of early‐life wheezing illnesses relates to childhood respiratory and asthma phenotypes. Methods: Data were collected prospectively on 429 children in the Urban Environment and Childhood Asthma (URECA) birth cohort study through age 10 years. We identified wheezing illnesses and the corresponding viral etiology (PCR testing of nasal mucus) during the first 3 years of life. Six phenotypes of respiratory health were identified at 10 years of age based on trajectories of wheezing, allergic sensitization, and lung function. We compared the etiology of early wheezing illnesses to these wheezing respiratory phenotypes and the development of asthma. Results: In the first 3 years of life, at least one virus was detected in 324 (67%) of the 483 wheezing episodes documented in the study cohort. Using hierarchical partitioning we found that non‐viral wheezing episodes accounted for the greatest variance in asthma diagnosed at both 7 and 10 years of age (8.0% and 5.8% respectively). Rhinovirus wheezing illnesses explained the most variance in respiratory phenotype outcome followed by non‐viral wheezing episodes (4.9% and 3.9% respectively) at 10 years of age. Conclusion and Relevance: Within this high‐risk urban‐residing cohort in early life, non‐viral wheezing episodes were frequently identified and associated with asthma development. Though rhinovirus wheezing illnesses had the greatest association with phenotype outcome, the specific etiology of wheezing episodes in early life provided limited information about subsequent wheezing phenotypes. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Follow-up to Adolescence after Early Peanut Introduction for Allergy Prevention.

Author

Du Toit, George, Huffaker, Michelle F., Radulovic, Suzana, Feeney, Mary, Fisher, Helen R., Byron, Margie, Dunaway, Lars, Calatroni, Agustin, Johnson, Molly, Foong, Ru-Xin, Marques-Mejias, Andreina, Bartha, Irene, Basting, Monica, Brough, Helen A., Baloh, Carolyn, Laidlaw, Tanya M., Bahnson, Henry T., Roberts, Graham, Plaut, Marshall, and Wheatley, Lisa M.

Subjects
FOOD allergy prevention, PEANUTS, IMMUNOLOGICAL tolerance, RESEARCH funding, STATISTICAL sampling, IMMUNOGLOBULINS, QUESTIONNAIRES, RANDOMIZED controlled trials, DESCRIPTIVE statistics, EARLY intervention (Education), LONGITUDINAL method, ANAPHYLAXIS, ADOLESCENCE
Abstract

Background: A randomized trial demonstrated consumption of peanut from infancy to age 5 years prevented the development of peanut allergy. An extension of that trial demonstrated the effect persisted after 1 year of peanut avoidance. This follow-up trial examined the durability of peanut tolerance at age 144 months after years of ad libitum peanut consumption. Methods: Participants from a randomized peanut consumption trial were assessed for peanut allergy following an extended period of eating or avoiding peanuts as desired. The primary end point was the rate of peanut allergy at age 144 months. Results: We enrolled 508 of the original 640 participants (79.4%); 497 had complete primary end point data. At age 144 months, peanut allergy remained significantly more prevalent in participants in the original peanut avoidance group than in the original peanut consumption group (15.4% [38 of 246 participants] vs. 4.4% [11 of 251 participants]; P<0.001). Participants in both groups reported avoiding peanuts for prolonged periods of time between 72 and 144 months. Participants at 144 months in the peanut consumption group had levels of Ara h2-specific immunoglobulin E (a peanut allergen associated with anaphylaxis) of 0.03 ± 3.42 kU/l and levels of peanut-specific immunoglobulin G4 of 535.5 ± 4.98 µg/l, whereas participants in the peanut avoidance group had levels of Ara h2-specific immunoglobulin E of 0.06 ± 11.21 kU/l and levels of peanut-specific immunoglobulin G4 of 209.3 ± 3.84 µg/l. Adverse events were uncommon, and the majority were related to the food challenge. Conclusions: Peanut consumption, starting in infancy and continuing to age 5 years, provided lasting tolerance to peanut into adolescence irrespective of subsequent peanut consumption, demonstrating that long-term prevention and tolerance can be achieved in food allergy. (Funded by the National Institute of Allergy and Infectious Diseases and others; ITN070AD, ClinicalTrials.gov number, NCT03546413.) [ABSTRACT FROM AUTHOR]

Published
2024
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17. Aeroallergen Sensitization, Serum IgE, and Eosinophilia as Predictors of Response to Omalizumab Therapy During the Fall Season Among Children with Persistent Asthma

Author

Sheehan, William J., Krouse, Rebecca Z., Calatroni, Agustin, Gergen, Peter J., Gern, James E., Gill, Michelle A., Gruchalla, Rebecca S., Khurana Hershey, Gurjit K., Kattan, Meyer, Kercsmar, Carolyn M., Lamm, Carin I., Little, Frederic F., Makhija, Melanie M., Searing, Daniel A., Zoratti, Edward, Busse, William W., and Teach, Stephen J.

Published
2020
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18. Expression quantitative trait locus fine mapping of the 17q12–21 asthma locus in African American children: a genetic association and gene expression study

Author

Achten, Niek, Ainsworth, John, Akkerman, Nonna, Anderson, Elizabeth, Anderson, Larry J., Andrews, Howard, Armagost, Elizabeth, Aubuchon, Mary Ann, Bach, Julia, Bacharier, Leonard, Barnes, Kathrine L., Barone, Charles, Bauer, Irma, Beamer, Paloma, Becker, Patrice, Bednarek, Alyssa, Bellemore, Stacey, Bendixsen, Casper G., Biagini Myers, Jocelyn M., Billheimer, Dean, Billstrand, Christine, Birg, Geraldine, Blocki, Shirley, Bloomberg, Gordon, Bobbitt, Kevin, Bochkov, Yury, Bourgeois, Karen, Boushey, Homer, Brockman-Schneider, Rebecca, Brunwasser, Steven M., Budrevich, Richard, Burkle, Jeffrey W., Busse, William, Calatroni, Agustin, Campbell, Janice, Carlson-Dakes, Kirsten, Cassidy-Bushrow, Andrea, Chappell, James D., Chasman, Deborah, Chipps, Teresa M., Chirkova, Tatiana, Cole, Deanna, Connolly, Alexandra, Cootauco, Michelle, Costello, Kaitlin, Couch, Philip, Coull, Brent, Craven, Mark, Crisafi, Gina, Cruikshank, William, Curtsinger, Kristi, Custovic, Adnan, Das, Suman R., DaSilva, Douglas, Datta, Soma, Davidson, Brent, De La Ossa, Lydia, DeVries, Mark, Di, Qian, Dixon, Samara, Donnerbauer, Erin, Dorst, Marian, Doyle, Susan, Dresen, Amy, Dupont, William D., Durrange, Janet, Erickson, Heidi, Evans, Michael D., Ezell, Jerel, Farnham, Leanna, Filardo-Collins, Roxanne, Finazzo, Salvatore, Flege, Zachary, Fleurat, Conner, Floerke, Heather, Floerke, Dorothy, Foss, Terry, Freie, Angela, Frome, Wayne, Fye, Samantha, Gagalis, Lisa, Gammell, Rebecca, Gangnon, Ronald E., Ge, James E., Gebretsadik, Tebeb, Gergen, Peter, Gern, James E., Gibson, Heike, Gjerasi, Edlira, Gold, Diane R., Gonzalez, Nicole, Goodman, Kayla, Gress, Lisa, Grindle, Kristine, Groeschen, Taylor, Hallmark, Brian, Halonen, Marilyn, Hart, Jaime, Hartert, Tina V., Havstad, Suzanne, Heinritz, Patrick, Hensley Alford, Sharon, Herbstman, Julie, Hernandez, Kellie, Hoepner, Lori, Jackson, Daniel J., Jadhao, Samadhan J., Jaffee, Katy, James, Peter, Jezioro, Jacqueline, Jimenez Pescador, Marcia, Johnson, Christine C., Johnson, Tara, Johnson, Camille, Jones, Amelia, Jones, Kyra, Jones, Paul, Jordan, Carolina, Joseph, Christine LM, Kattan, Meyer, Keidel, Kristina, Keifer, Matthew C., Kelley, Rick, Khurana Hershey, Gurgit K., Kim, Haejin, Kloog, Itai, Koepel, Tammy Kronenwetter, Koerkenmeier, Clint, Ladick, Laura, Lamm, Carin, Larkin, Emma, Lederman, Howard, Lee-Parritz, Aviva, Leimenstoll, Stephanie, Lemanske, Jr., Robert F., LeMasters, Grace K., Levin, Albert M., Levine, Jessica, Liu, Xinhua, Liu, Zhouwen, Lopez, Silvia, Lothrop, Nathan, Lovinsky-Desir, Stephanie, Lukacs, Nicholas, Lynch, Susan, Lynch, Christian, Mann, Erik, Martin, Jennifer, Martin, Lisa, Martinez, Fernando D., Matsui, Elizabeth, McCauley, Katherine, Mccollum, Megan, McCullough, Judith, McKennon, Chris G., Meece, Jennifer, Mendonca, Eneida, Mikus, Lance, Miller, Rachel L., Minton, Patricia, Mitchell, Herman, Moon, Vicki, Moore, Paul E., Morgan, Wayne, Morgan, Valerie, Morgan, David, Murrison, Liza, Nicholas, Charlotte, Nicolae, Daniel, Nunez, Adam, O'Connor, George, O'Toole, Sharon, Ober, Carole, Olson, Brent F., Ong, Irene, Osmundson, Sarah, Ownby, Dennis, Pappas, Tressa, Perera, Frederica, Perzanowski, Matthew, Peterson, Edward, Pierce, Marcela, Price-Johnson, Penny, Rajamanickam, Victoria, Ramirez, Judyth, Ray, Kimberly, Renneberg, Megan, Requia, Weeberb, Riley, Kylie, Rivera, Janelle, Rivers, Neisha, Roberg, Kathy, Rogers, Theresa, Rosas-Salazar, Christian, Russell, Pat, Ryan, Patrick H., Sadovsky, Yoel, Salazar, Lisa, Sampson, Hugh, Sandel, Megan, Schoettler, Nathan, Schwartz, Joel, Scott, Dena, Seroogy, Christine M., Sharp, Renee, Shilts, Meghan H., Sigelman, Steve, Singh, Anne Marie, Sitarik, Alexandra, Smartt, Ernestine, Sorkness, Ronald, Sorkness, Christine, Spangenberg, Amber, Sperling, Rhoda, Spies, David, Stern, Debra A., Stoffel, Brandy, Peebles, R. Stokes, Stouffer, Gina, Strauchman Boyer, Cathey, Suddeuth, Caitlin, Tachinardi, Umberto, Tang, Deliang, Tang, Zhengzheng, Tate, Jena, Taylor, William, Tensing, Krista, Tesson, Elizabeth, Thompson, Kathy, Thompson, Emma, Tisler, Christopher, Togias, Alkis, Turi, Kedir, Turner, Victoria, Tuzova, Marina, VanWormer, Jeffrey J., Visness, Cynthia M., Vrtis, Rose, Wahlman, Anthony, Wang, Lena, Wegienka, Ganesa, Wells, Karen, Wentworth-Sheilds, William, Wheatley, Lisa, Whitney, Nitsa, Williams, L. Keoki, Witter, Frank, Wolfe, Christopher, Wood, Robert A., Woodcroft, Kimberley, Woodward, Kim B., Wright, Anne L., Wright, Rosalind, Wu, Pingsheng, Yaeger, Melissa, Yaniv, Perri, Zanobetti, Antonella, Zhang, Shirley, Zook, Patricia, Zoratti, Edward M., McKennan, Chris G, Magnaye, Kevin M, Altman, Matthew C, Washington, Charles, 3rd, Stanhope, Catherine, Naughton, Katherine A, Rosasco, Mario G, Bacharier, Leonard B, Gold, Diane R, Hartert, Tina, Khurana Hershey, Gurjit K, Hogarth, D Kyle, Jackson, Daniel J, Johnson, Christine C, Lemanske, Robert F, Lynch, Susan V, Mendonca, Eneida A, Miller, Rachel L, Naureckas, Edward T, O'Connor, George T, Seroogy, Christine M, White, Steven R, Wood, Robert A, Wright, Anne L, Zoratti, Edward M, Martinez, Fernando D, Nicolae, Dan L, Levin, Albert M, and Gern, James E

Published
2020
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19. An Unintentional Randomized Trial of Early Environmental Exposure to Peanut: The Younger Siblings of LEAP Participants

Author

Lack, Gideon, primary, Du Toit, George, additional, Radulovic, Suzana, additional, Feeney, Mary, additional, Fischer, Helen, additional, Byron, Margie, additional, Dunaway, Lars, additional, Calatroni, Agustin, additional, Johnson, Molly, additional, Foong, Ru-Xin, additional, Marques-Mejias, Andreina, additional, Bartha, Irene, additional, Brough, Helen, additional, Basting, Monica, additional, Baloh, Carolyn, additional, Laidlaw, Tanya, additional, Bahnson, Henry, additional, Roberts, Graham, additional, Plaut, Marshall, additional, Wheatley, Lisa, additional, and Huffaker, Michelle, additional

Published
2024
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20. Omalizumab for the Treatment of Multiple Food Allergy (OUtMATCH)

Author

Wood, Robert, primary, Togias, Alkis, additional, Sicherer, Scott, additional, Shreffler, Wayne, additional, Kim, Edwin, additional, Jones, Stacie, additional, Leung, Donald, additional, Vickery, Brian, additional, Bird, J. Andrew, additional, Spergel, Jonathan, additional, Iqbal, Ahmar, additional, Olsson, Julie, additional, Ligueros-Saylan, Monica, additional, Uddin, Alkaz, additional, Calatroni, Agustin, additional, Huckabee, Charmaine, additional, Rogers, Nicole, additional, Yovetich, Nancy, additional, Dantzer, Jennifer, additional, Mudd, Kim, additional, Wang, Julie, additional, Groetch, Marion, additional, Pyle, David, additional, Keet, Corinne, additional, Kulis, Michael, additional, Sindher, Sayantani, additional, Long, Andrew, additional, Scurlock, Amy, additional, Lanser, Bruce, additional, Lee, Tricia, additional, Parrish, Christopher, additional, Brown-Whitehorn, Terri, additional, Spergel, Amanda Rudman, additional, Veri, Maria, additional, Hamrah, Sanaz, additional, Brittain, Erica, additional, Poyser, Julian, additional, Wheatley, Lisa, additional, and Chinthrajah, R. Sharon, additional

Published
2024
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21. Cutaneous Ceramide Synthase 1 (CERS1) Gene Expression is a Biomarker of Staphylococcus aureus Abundance and Severity of Atopic Dermatitis

Author

Kenney, H. Mark, primary, Yoshida, Takeshi, additional, Berdyshev, Evgeny, additional, Calatroni, Agustin, additional, Gill, Steven, additional, Simpson, Eric, additional, Lussier, Stephanie, additional, Boguniewicz, Mark, additional, Hata, Tissa, additional, Fuxench, Zelma, additional, De Benedetto, Anna, additional, Ong, Peck, additional, Ko, Justin, additional, Davidson, Wendy, additional, David, Gloria, additional, Schlievert, Patrick, additional, Leung, Donald, additional, and Beck, Lisa, additional

Published
2024
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22. Heterogeneity of cockroach allergen-specific T cell responses in allergic sensitized children

Author

Antunes, Ricardo da Silva, primary, Sutherland, Aaron, additional, Frazier, April, additional, Schulten, Veronique, additional, Pomés, Anna, additional, Glesner, Jill, additional, Calatroni, Agustin, additional, Altman, Matthew, additional, Wood, Robert A., additional, O'Connor, George, additional, Pongracic, Jackie, additional, Hershey, Gurjit Khurana, additional, Kercsmar, Carolyn, additional, Gruchalla, Rebecca, additional, Gill, Michelle, additional, Liu, Andrew, additional, Zoratti, Edward, additional, Kattan, Meyer, additional, Busse, Paula, additional, Bacharier, Leonard, additional, Teach, Stephen, additional, Wheatley, Lisa, additional, Togias, Alkis, additional, Busse, William, additional, Jackson, Daniel, additional, and Sette, Alessandro, additional

Published
2024
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27. Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children

Author

Lynch, Susan V, Wood, Robert A, Boushey, Homer, Bacharier, Leonard B, Bloomberg, Gordon R, Kattan, Meyer, O’Connor, George T, Sandel, Megan T, Calatroni, Agustin, Matsui, Elizabeth, Johnson, Christine C, Lynn, Henry, Visness, Cynthia M, Jaffee, Katy F, Gergen, Peter J, Gold, Diane R, Wright, Rosalind J, Fujimura, Kei, Rauch, Marcus, Busse, William W, and Gern, James E

Subjects
Asthma, Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Prevention, Pediatric, Lung, Aetiology, 2.2 Factors relating to the physical environment, Inflammatory and immune system, Respiratory, Sustainable Cities and Communities, Allergens, Antigens, Bacterial, Bacteria, Case-Control Studies, Child, Preschool, Cohort Studies, Dust, Environmental Exposure, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Recurrence, Respiratory Sounds, Risk, United States, Urban Population, atopy, allergen exposure, microbial exposure, inner city, Immunology, Allergy
Abstract

BackgroundWheezing illnesses cause major morbidity in infants and are frequent precursors to asthma.ObjectiveWe sought to examine environmental factors associated with recurrent wheezing in inner-city environments.MethodsThe Urban Environment and Childhood Asthma study examined a birth cohort at high risk for asthma (n = 560) in Baltimore, Boston, New York, and St Louis. Environmental assessments included allergen exposure and, in a nested case-control study of 104 children, the bacterial content of house dust collected in the first year of life. Associations were determined among environmental factors, aeroallergen sensitization, and recurrent wheezing at age 3 years.ResultsCumulative allergen exposure over the first 3 years was associated with allergic sensitization, and sensitization at age 3 years was related to recurrent wheeze. In contrast, first-year exposure to cockroach, mouse, and cat allergens was negatively associated with recurrent wheeze (odds ratio, 0.60, 0.65, and 0.75, respectively; P ≤ .01). Differences in house dust bacterial content in the first year, especially reduced exposure to specific Firmicutes and Bacteriodetes, was associated with atopy and atopic wheeze. Exposure to high levels of both allergens and this subset of bacteria in the first year of life was most common among children without atopy or wheeze.ConclusionsIn inner-city environments children with the highest exposure to specific allergens and bacteria during their first year were least likely to have recurrent wheeze and allergic sensitization. These findings suggest that concomitant exposure to high levels of certain allergens and bacteria in early life might be beneficial and suggest new preventive strategies for wheezing and allergic diseases.

Published
2014

29. Development of a standardized approach for environmental microbiota investigations related to asthma development in children

Author

Fujimura, Kei E, Rauch, Marcus, Matsui, Elizabeth, Iwai, Shoko, Calatroni, Agustin, Lynn, Henry, Mitchell, Herman, Johnson, Christine C, Gern, James E, Togias, Alkis, Boushey, Homer A, Kennedy, Suzanne, and Lynch, Susan V

Subjects
Microbiology, Biological Sciences, Lung, Genetics, Human Genome, Pediatric, Clinical Research, Asthma, Biota, Child, Dust, Environmental Microbiology, Humans, Metagenome, Metagenomics, Microarray Analysis, Phylogeny, RNA, Ribosomal, 16S, Sequence Analysis, DNA, Dust microbiome, Standardized sampling, Phylogenetic microarray, 454-Pyrosequencing, Medical Microbiology
Abstract

Standardized studies examining environmental microbial exposure in populations at risk for asthma are necessary to improve our understanding of the role this factor plays in disease development. Here we describe studies aimed at developing guidelines for high-resolution culture-independent microbiome profiling, using a phylogenetic microarray (PhyloChip), of house dust samples in a cohort collected as part of the NIH-funded Inner City Asthma Consortium (ICAC). We demonstrate that though extracted DNA concentrations varied across dust samples, the majority produced sufficient 16S rRNA to be profiled by the array. Comparison of array and 454-pyrosequencing performed in parallel on a subset of samples, illustrated that increasingly deeper sequencing efforts validated greater numbers of array-detected taxa. Community composition agreement across samples exhibited a hierarchy in concordance, with the highest level of agreement in replicate array profiles followed by samples collected from adjacent 1×1 m(2) sites in the same room, adjacent sites with different sized sampling quadrants (1×1 and 2×2 m(2)), different sites within homes (living and bedroom) to lowest in living room samples collected from different homes. The guidelines for sample collection and processing in this pilot study extend beyond PhyloChip based studies of house-associated microbiota, and bear relevance for other microbiome profiling approaches such as next-generation sequencing.

Published
2012

30. Developing a Prediction Model for Determination of Peanut Allergy Status in the Learning Early About Peanut Allergy (LEAP) Studies

Author

Sever, Michelle L, Calatroni, Agustin, Roberts, Graham, du Toit, George, Bahnson, Henry T, Radulovic, Suzana, Larson, David, Byron, Margie, Santos, Alexandra F, Huffaker, Michelle F, Wheatley, Lisa M, and Lack, Gideon

Abstract

Background: The Learning Early About Peanut Allergy (LEAP) study team developed a protocol-specific algorithm using dietary history, peanut-specific IgE, and skin prick test (SPT) to determine peanut allergy status if the oral food challenge (OFC) could not be administered or did not provide a determinant result.Objective: To investigate how well the algorithm determined allergy status in LEAP; to develop a new prediction model to determine peanut allergy status when OFC results are not available in LEAP Trio, a follow-up study of LEAP participants and their families; and to compare the new prediction model with the algorithm.Methods: The algorithm was developed for the LEAP protocol before the analysis of the primary outcome. Subsequently, a prediction model was developed using logistic regression.Results: Using the protocol-specified algorithm, 73% (453/617) of allergy determinations matched the OFC, 0.6% (4/617) were mismatched, and 26% (160/617) participants were nonevaluable. The prediction model included SPT, peanut-specific IgE, Ara h 1, Ara h 2, and Ara h 3. The model inaccurately predicted 1 of 266 participants as allergic who were not allergic by OFC and 8 of 57 participants as not allergic who were allergic by OFC. The overall error rate was 9 of 323 (2.8%) with an area under the curve of 0.99. The prediction model additionally performed well in an external validation cohort.Conclusion: The prediction model performed with high sensitivity and accuracy, eliminated the problem of nonevaluable outcomes, and can be used to estimate peanut allergy status in the LEAP Trio study when OFC is not available.

Published
2023

31. ISID1599 - Rapid reduction in S. aureus in atopic dermatitis subjects following dupilumab treatment

Author

A Beck, Lisa, primary, Simpson, Eric, primary, M. Schlievert, Patrick, primary, Yoshida, Takeshi, primary, Lussier, Stephanie, primary, Boguniewicz, Mark, primary, Hata, Tissa, primary, Chiesa Fuxench, Zelma, primary, De Benedetto, Anna, primary, Y. Ong, Peck, primary, Ko, Justin, primary, Calatroni, Agustin, primary, Plaut, Marshall, primary, A. Quataert, Sally, primary, H. Kilgore, Samuel, primary, Peterson, Liam, primary, Bunny, Dumb, primary, David, Gloria, primary, Mosmann, Tim, primary, Richard Gill, Steven, primary, and Y.M. Leung, Donald, primary

Published
2023
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33. Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations

Author

Teach, Stephen J., Gill, Michelle A., Togias, Alkis, Sorkness, Christine A., Arbes, Samuel J., Jr., Calatroni, Agustin, Wildfire, Jeremy J., Gergen, Peter J., Cohen, Robyn T., Pongracic, Jacqueline A., Kercsmar, Carolyn M., Khurana Hershey, Gurjit K., Gruchalla, Rebecca S., Liu, Andrew H., Zoratti, Edward M., Kattan, Meyer, Grindle, Kristine A., Gern, James E., Busse, William W., and Szefler, Stanley J.

Published
2015
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34. Comparison of Rhinitis Phenotypes with the Development of Asthma by Age 10 in an Urban Birth Cohort

Author

Tanis, Ross, primary, Calatroni, Agustin, additional, Bacharier, Leonard, additional, Little, Frederic, additional, Sandel, Megan, additional, Rivera-Spoljaric, Katherine, additional, Visness, Cynthia, additional, Togias, Alkis, additional, Gergen, Peter, additional, Gern, James, additional, Ramratnam, Sima, additional, Lamm, Carin, additional, Wood, Robert, additional, and Johnson, Molly, additional

Published
2023
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35. Mepolizumab Alters Regulation of Airway Type-2 Inflammation in Urban Children with Asthma by Disrupting Eosinophil Gene Expression but Enhancing Mast Cell and Epithelial Pathways

Author

Gaberino, Courtney, primary, Segnitz, R. Max, additional, Cox, Madison, additional, Bacharier, Leonard, additional, Calatroni, Agustin, additional, Gill, Michelle, additional, Stokes, Jeffrey, additional, Liu, Andrew, additional, Cohen, Robyn, additional, Makhija, Melanie, additional, Hershey, Gurjit Khurana, additional, O'Connor, George, additional, Zoratti, Edward, additional, Teach, Stephen, additional, Kattan, Meyer, additional, Becker, Patrice, additional, Togias, Alkis, additional, Busse, William, additional, Jackson, Daniel, additional, and Altman, Matthew, additional

Published
2023
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36. Epithelial-Associated Inflammatory Pathways Underlie Residual Asthma Exacerbations in Urban Children Treated with Mepolizumab Therapy

Author

Patel, Sana, primary, Altman, Matthew, additional, Cox, Madison, additional, Bacharier, Leonard, additional, Calatroni, Agustin, additional, Gill, Michelle, additional, Stokes, Jeffrey, additional, Liu, Andrew, additional, Cohen, Robyn, additional, Makhija, Melanie, additional, Hershey, Gurjit Khurana, additional, O’Connor, George, additional, Zoratti, Edward, additional, Teach, Stephen, additional, Kattan, Meyer, additional, Becker, Patrice, additional, Togias, Alkis, additional, Busse, William, additional, and Jackson, Daniel, additional

Published
2023
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37. The Effect of Subcutaneous German Cockroach Immunotherapy (SCIT) on Nasal Allergen Challenge (NAC) and Cockroach-specific Antibody Responses Among Urban Children and Adolescents

Author

Zoratti, Edward, primary, Wood, Robert, additional, O, George, additional, Pongracic, Jacqueline, additional, Makhija, Melanie, additional, Hershey, Gurjit Khurana, additional, Sherenian, Michael, additional, Gill, Michelle, additional, Gruchalla, Rebecca, additional, Chambliss, Jeffrey, additional, Liu, Andrew, additional, Kattan, Meyer, additional, Busse, Paula, additional, Bacharier, Leonard, additional, Rivera-Spoljaric, Katherine, additional, Sheehan, William, additional, Jackson, Daniel, additional, Gergen, Peter, additional, Togias, Alkis, additional, Calatroni, Agustin, additional, Visness, Cynthia, additional, Cho, Kate, additional, Sette, Alessandro, additional, Altman, Matthew, additional, and Busse, William, additional

Published
2023
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38. Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings

Author

Dapas, Matthew, primary, Thompson, Emma E., additional, Wentworth-Sheilds, William, additional, Clay, Selene, additional, Visness, Cynthia M., additional, Calatroni, Agustin, additional, Sordillo, Joanne E., additional, Gold, Diane R., additional, Wood, Robert A., additional, Makhija, Melanie, additional, Khurana Hershey, Gurjit K., additional, Sherenian, Michael G., additional, Gruchalla, Rebecca S., additional, Gill, Michelle A., additional, Liu, Andrew H., additional, Kim, Haejin, additional, Kattan, Meyer, additional, Bacharier, Leonard B., additional, Rastogi, Deepa, additional, Altman, Matthew C., additional, Busse, William W., additional, Becker, Patrice M., additional, Nicolae, Dan, additional, O’Connor, George T., additional, Gern, James E., additional, Jackson, Daniel J., additional, and Ober, Carole, additional

Published
2023
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39. Effects of Worry About COVID-19 on Activities that Increase Risk of SARS-CoV-2 Infection in a 12-City Surveillance Study of Households with Children

Author

Brunwasser, Steven M., primary, Gebretsadik, Tebeb, additional, Cole, Jennifer C., additional, Dupont, William D., additional, Satish, Anisha, additional, Joseph, Christine, additional, Bendixsen, Casper G., additional, Calatroni, Agustin, additional, Arbes Jr, Samuel J., additional, Fulkerson, Patricia C., additional, Sanders, Joshua, additional, Bacharier, Leonard B., additional, Camargo, Carlos, additional, Cole Johnson, Christine, additional, Furuta, Glenn T., additional, Gruchalla, Rebecca S., additional, Gupta, Ruchi S., additional, Khurana Hershey, Gurjit K., additional, Jackson, Daniel J., additional, Kattan, Meyer, additional, Liu, Andrew H., additional, O’Connor, George T., additional, Rivera-Spoljaric, Katherine, additional, Phipatanakul, Wanda, additional, Rothenberg, Marc E., additional, Seibold, Max A., additional, Seroogy, Christine M., additional, Teach, Stephen J., additional, Zoratti, Edward M., additional, Togias, Alkis, additional, and Hartert, Tina V., additional

Published
2023
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41. DNA methylation and childhood asthma in the inner city

Author

Yang, Ivana V., Pedersen, Brent S., Liu, Andrew, O'Connor, George T., Teach, Stephen J., Kattan, Meyer, Misiak, Rana Tawil, Gruchalla, Rebecca, Steinbach, Suzanne F., Szefler, Stanley J., Gill, Michelle A., Calatroni, Agustin, David, Gloria, Hennessy, Corinne E., Davidson, Elizabeth J., Zhang, Weiming, Gergen, Peter, Togias, Alkis, Busse, William W., and Schwartz, David A.

Published
2015
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46. Risk factors for SARS-CoV-2 infection and transmission in households with children with asthma and allergy: A prospective surveillance study

Author

Seibold, Max A., primary, Moore, Camille M., additional, Everman, Jamie L., additional, Williams, Blake J.M., additional, Nolin, James D., additional, Fairbanks-Mahnke, Ana, additional, Plender, Elizabeth G., additional, Patel, Bhavika B., additional, Arbes, Samuel J., additional, Bacharier, Leonard B., additional, Bendixsen, Casper G., additional, Calatroni, Agustin, additional, Camargo, Carlos A., additional, Dupont, William D., additional, Furuta, Glenn T., additional, Gebretsadik, Tebeb, additional, Gruchalla, Rebecca S., additional, Gupta, Ruchi S., additional, Khurana Hershey, Gurjit K., additional, Murrison, Liza Bronner, additional, Jackson, Daniel J., additional, Johnson, Christine C., additional, Kattan, Meyer, additional, Liu, Andrew H., additional, Lussier, Stephanie J., additional, O’Connor, George T., additional, Rivera-Spoljaric, Katherine, additional, Phipatanakul, Wanda, additional, Rothenberg, Marc E., additional, Seroogy, Christine M., additional, Teach, Stephen J., additional, Zoratti, Edward M., additional, Togias, Alkis, additional, Fulkerson, Patricia C., additional, and Hartert, Tina V., additional

Published
2022
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47. Seasonal airway microbiome and transcriptome interactions promote childhood asthma exacerbations

Author

McCauley, Kathryn E., primary, Flynn, Kaitlin, additional, Calatroni, Agustin, additional, DiMassa, Vincent, additional, LaMere, Brandon, additional, Fadrosh, Douglas W., additional, Lynch, Kole V., additional, Gill, Michelle A., additional, Pongracic, Jacqueline A., additional, Khurana Hershey, Gurjit K., additional, Kercsmar, Carolyn M., additional, Liu, Andrew H., additional, Johnson, Christine C., additional, Kim, Haejin, additional, Kattan, Meyer, additional, O’Connor, George T., additional, Bacharier, Leonard B., additional, Teach, Stephen J., additional, Gergen, Peter J., additional, Wheatley, Lisa M., additional, Togias, Alkis, additional, LeBeau, Petra, additional, Presnell, Scott, additional, Boushey, Homer A., additional, Busse, William W., additional, Gern, James E., additional, Jackson, Daniel J., additional, Altman, Matthew C., additional, and Lynch, Susan V., additional

Published
2022
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48. Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings

Author

Dapas, Matthew, primary, Thompson, Emma E., additional, Wentworth-Sheilds, William, additional, Clay, Selene M., additional, Visness, Cynthia M., additional, Calatroni, Agustin, additional, Sordillo, Joanne E., additional, Gold, Diane R., additional, Wood, Robert A., additional, Makhija, Melanie, additional, Khurana Hershey, Gurjit K., additional, Sherenian, Michael G., additional, Gruchalla, Rebecca S., additional, Gill, Michelle A., additional, Liu, Andrew H., additional, Kim, Haejin, additional, Kattan, Meyer, additional, Bacharier, Leonard B., additional, Rastogi, Deepa, additional, Altman, Matthew C., additional, Busse, William W., additional, Becker, Patrice M., additional, Nicolae, Dan L., additional, O'Connor, George T., additional, Gern, James E., additional, Jackson, Daniel J., additional, and Ober, Carole, additional

Published
2022
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