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1. Dysregulated Lipid Metabolism Precedes Onset of Psychosis

Author: McGuire, Philip, Valmaggia, Lucia R., Kempton, Matthew J., Calem, Maria, Tognin, Stefania, Modinos, Gemma, de Haan, Lieuwe, van der Gaag, Mark, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Amminger, G. Paul, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Riecher-Rössler, Anita, Borgwardt, Stefan, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Barrantes-Vidal, Neus, Domínguez-Martínez, Tecelli, Racciopi, Anna, Kwapil, Thomas R., Monsonet, Manel, Rosa, Araceli, Frajerman, Ariel, Chaumette, Boris, Bourgin, Julie, Kebir, Oussama, Jantac, Célia, Krebs, Marie-Odile, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise, Glenthøj, Birte, Nordentoft, Merete, Ruhrmann, Stephan, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Sachs, Gabriele, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., Rutten, Bart P., van Os, Jim, Dickens, Alex M., Sen, Partho, Iyegbe, Conrad, Pollak, Thomas, Valmaggia, Lucia, Hyötyläinen, Tuulia, and Orešič, Matej more...
Published: 2021
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2. Gender differences of patients at-risk for psychosis regarding symptomatology, drug use, comorbidity and functioning – Results from the EU-GEI study

Author: Menghini-Müller, Stephanie, Studerus, Erich, Ittig, Sarah, Heitz, Ulrike, Egloff, Laura, Andreou, Christina, Valmaggia, Lucia R., Kempton, Matthew J., van der Gaag, Mark, de Haan, Lieuwe, Nelson, Barnaby, Barrantes-Vidal, Neus, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P., Os, Jim van, Riecher-Rössler, Anita, McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, McGorry, Patrick, Amminger, G Paul, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Rapp, Charlotte, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Racioppi, Anna, Cristóbal-Narváez, Paula, Kwapil, Thomas R., Monsonet, Manel, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Célia, Krebs, Marie-Odile, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise, Glenthøj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., and van Os, Jim more...
Published: 2019
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3. Meta-analysis of associations between childhood adversity and hippocampus and amygdala volume in non-clinical and general population samples

Author: Calem, Maria, Bromis, Konstantinos, McGuire, Philip, Morgan, Craig, and Kempton, Matthew J
Published: 2017
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4. Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis

Author: Ong, Hui Lin, Isvoranu, Adela-Maria, Schirmbeck, Frederike, McGuire, Philip, Valmaggia, Lucia, Kempton, Matthew J., van der Gaag, Mark, Riecher-Rössler, Anita, Bressan, Rodrigo A., Barrantes-Vidal, Neus, Nelson, Barnaby, Amminger, G. Paul, McGorry, Patrick, Pantelis, Christos, Krebs, Marie-Odile, Nordentoft, Merete, Glenthøj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, de Haan, Lieuwe, Borsboom, Denny, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Pisani, Sara, Hedges, Emily, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Monsonet, Manel, Hinojosa, Lidia, Racioppi, Anna, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, C. lia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise Birkedal, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., University of Amsterdam [Amsterdam] (UvA), Arkin Institute for Mental Health [Amsterdam, The Netherlands] (AIMH), King‘s College London, Vrije Universiteit Amsterdam [Amsterdam] (VU), Universitätsspital Basel [Switzerland], Universidade Federal de São Paulo, Universitat Autònoma de Barcelona (UAB), Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), University of Melbourne, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), University of Copenhagen = Københavns Universitet (KU), University of Cologne, Medizinische Universität Wien = Medical University of Vienna, Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], Utrecht University [Utrecht], EU-GEI High Risk Study: Maria Calem, Stefania Tognin, Gemma Modinos, Sara Pisani, Emily Hedges, Eva Velthorst, Tamar C Kraan, Daniella S van Dam, Nadine Burger, Athena Politis, Joanne Goodall, Stefan Borgwardt, Erich Studerus, Ary Gadelha, Elisa Brietzke, Graccielle Asevedo, Elson Asevedo, Andre Zugman, Tecelli Domínguez-Martínez, Manel Monsonet, Lidia Hinojosa, Anna Racioppi, Thomas R Kwapil, Mathilde Kazes, Claire Daban, Julie Bourgin, Olivier Gay, Célia Mam-Lam-Fook, Dorte Nordholm, Lasse Randers, Kristine Krakauer, Louise Birkedal Glenthøj, Dominika Gebhard, Julia Arnhold, Joachim Klosterkötter, Iris Lasser, Bernadette Winklbaur, Philippe A Delespaul, Adult Psychiatry, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, ANS - Complex Trait Genetics, Psychologische Methodenleer (Psychologie, FMG), Clinical Psychology, RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie, MUMC+: MA Psychiatrie (3), RS: MHeNs - R2 - Mental Health, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), University of Copenhagen = Københavns Universitet (UCPH), and Martinez Rico, Clara more...
Subjects: Male, DISORDER, Obsessive-Compulsive Disorder, Ultra-high risk, obsessive-compulsive, Psychological intervention, clinical high risk, Anxiety, 0302 clinical medicine, SCHIZOPHRENIA, COMPREHENSIVE ASSESSMENT, psychosis, Social isolation, network analysis, Depression (differential diagnoses), ASSOCIATIONS, Psychiatry, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Obsessive-compulsive, Depression, Clinical high risk, anxiety, CHILDHOOD TRAUMA, Psychiatry and Mental health, Schizophrenia, depression, Blunted Affect, Female, Network analysis, medicine.symptom, Life Sciences & Biomedicine, Clinical psychology, Adult, Psychosis, AcademicSubjects/MED00810, Risk Assessment, ultra-high risk, 03 medical and health sciences, Young Adult, medicine, Humans, METAANALYSIS, VULNERABILITY, SPECTRUM, Science & Technology, business.industry, At risk mental state, medicine.disease, 030227 psychiatry, INDIVIDUALS, Psychotic Disorders, Case-Control Studies, business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Regular Articles
Abstract: Background The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. Method Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. Results Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. Conclusions Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence. more...
Published: 2021
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5. The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis

Author: Tognin, Stefania, Richter, Anja, Kempton, Matthew J., Modinos, Gemma, Antoniades, Mathilde, Azis, Matilda, Allen, Paul, Bossong, Matthijs G., Perez, Jesus, Pantelis, Christos, Nelson, Barnaby, Amminger, Paul, Riecher-Rössler, Anita, Barrantes-Vidal, Neus, Krebs, Marie Odile, Glenthøj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P., De Haan, Lieuwe, Van Der Gaag, Mark, Mcguire, Philip, Valmaggia, Lucia R., Calem, Maria, Pisani, Sara, Velthorst, Eva, Kraan, Tamar C., Van Dam, Daniella S., Burger, Nadine, Mcgorry, Patrick, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Racciopi, Anna, Kwapil, Thomas R., Monsonet, Manel, Hinojosa, Lídia, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise, Nordentoft, Merete, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Aschauer, Harald, Delespaul, Philippe A., Van Os, Jim, Tognin, Stefania, Richter, Anja, Kempton, Matthew J., Modinos, Gemma, Antoniades, Mathilde, Azis, Matilda, Allen, Paul, Bossong, Matthijs G., Perez, Jesus, Pantelis, Christos, Nelson, Barnaby, Amminger, Paul, Riecher-Rössler, Anita, Barrantes-Vidal, Neus, Krebs, Marie Odile, Glenthøj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P., De Haan, Lieuwe, Van Der Gaag, Mark, Mcguire, Philip, Valmaggia, Lucia R., Calem, Maria, Pisani, Sara, Velthorst, Eva, Kraan, Tamar C., Van Dam, Daniella S., Burger, Nadine, Mcgorry, Patrick, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Racciopi, Anna, Kwapil, Thomas R., Monsonet, Manel, Hinojosa, Lídia, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise, Nordentoft, Merete, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Aschauer, Harald, Delespaul, Philippe A., and Van Os, Jim more...
Abstract: Objective: To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcomes in people at clinical high risk (CHR) for psychosis. Methods: 265 CHR individuals and 92 healthy controls were recruited as part of a prospective multi-center study. After a baseline assessment using magnetic resonance imaging (MRI), participants were followed for at least two years to determine clinical and functional outcomes, including transition to psychosis (according to the Comprehensive Assessment of an At Risk Mental State, CAARMS), level of functioning (according to the Global Assessment of Functioning), and symptomatic remission (according to the CAARMS). GMV was measured in selected cortical and subcortical regions of interest (ROI) based on previous studies (ie orbitofrontal gyrus, cingulate gyrus, gyrus rectus, inferior temporal gyrus, parahippocampal gyrus, striatum, and hippocampus). Using voxel-based morphometry, we analysed the relationship between GMV and clinical and functional outcomes. Results: Within the CHR sample, a poor functional outcome (GAF < 65) was associated with relatively lower GMV in the right striatum at baseline (P <. 047 after Family Wise Error correction). There were no significant associations between baseline GMV and either subsequent remission or transition to psychosis. Conclusions: In CHR individuals, lower striatal GMV was associated with a poor level of overall functioning at follow-up. This finding was not related to effects of antipsychotic or antidepressant medication. The failure to replicate previous associations between GMV and later psychosis onset, despite studying a relatively large sample, is consistent with the findings of recent large-scale multi-center studies. more...
Published: 2022

6. Modeling the Interplay Between Psychological Processes and Adverse, Stressful Contexts and Experiences in Pathways to Psychosis: An Experience Sampling Study

Author: Klippel, Annelie, Myin-Germeys, Inez, Chavez-Baldini, UnYoung, Preacher, Kristopher J., Kempton, Matthew, Valmaggia, Lucia, Calem, Maria, So, Suzanne, Beards, Stephanie, Hubbard, Kathryn, Gayer-Anderson, Charlotte, Onyejiaka, Adanna, Wichers, Marieke, McGuire, Philip, Murray, Robin, Garety, Philippa, van Os, Jim, Wykes, Til, Morgan, Craig, and Reininghaus, Ulrich more...
Published: 2017
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7. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project

Author: Calem, Maria, Tognin, Stefania, Modinos, Gemma, Pisani, Sara, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, McGorry, Patrick, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Monsonet, Manel, Hinojosa, Lidia, Cristóbal-Narváez, Paula, Racioppi, Anna, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Célia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise Birkedal, Glenthøj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Szöke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rössler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P.F., van Os, Jim, Velthorst, Eva, and de Haan, Lieuwe more...
Published: 2021
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8. Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis

Author: Pollak, Thomas A, Kempton, Matthew J, Iyegbe, Conrad, Vincent, Angela, Irani, Sarosh R, Coutinho, Ester, Menassa, David A, Jacobson, Leslie, de Haan, Lieuwe, Ruhrmann, Stephan, Sachs, Gabriele, Riecher-Roessler, Anita, Krebs, Marie-Odile, Amminger, Paul, Glenthoj, Birte, Barrantes-Vidal, Neus, van Os, Jim, Rutten, Bart PF, Bressan, Rodrigo A, van der Gaag, Mark, Yolken, Robert, Hotopf, Matthew, Valmaggia, Lucia, Stone, James, David, Anthony S, McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C, van Dam, Daniella S, Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Rosa, Araceli, Racioppi, Anna, Monsonet, Manel, Hinojosa-Marques, Lidia, Kwapil, Thomas R, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise, Nordentoft, Merete, Gebhard, Dominika, Arnhold, Julia, Klosterkoetter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A, Clinical Psychology, APH - Mental Health, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, Adult Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, and Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep more...
Subjects: Psychosis, Biochemistry & Molecular Biology, NEURONAL AUTOANTIBODIES, Verbal learning, Prognostic markers, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, ASPARTATE RECEPTOR AUTOANTIBODIES, medicine, 1ST-EPISODE PSYCHOSIS, LIMBIC ENCEPHALITIS, RATING-SCALE, BRAIN, Molecular Biology, Autoimmune disease, Autoimmune encephalitis, Psychiatry, Science & Technology, HIPPOCAMPAL, business.industry, Limbic encephalitis, Case-control study, Autoantibody, Neurosciences, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, INDIVIDUALS, nervous system, Immunology, ANTIBODIES, Schizophrenia, MENTAL STATE, Neurosciences & Neurology, business, Life Sciences & Biomedicine, 030217 neurology & neurosurgery, Neuroscience, Psychopathology
Abstract: Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic disorders. It is not known if they are present before the onset of psychosis or whether they are associated with particular clinical features or outcomes. In a case–control study, sera from 254 subjects at clinical high risk (CHR) for psychosis and 116 healthy volunteers were tested for antibodies against multiple neuronal antigens implicated in CNS autoimmune disorders, using fixed and live cell-based assays (CBAs). Within the CHR group, the relationship between NMDAR antibodies and symptoms, cognitive function and clinical outcomes over 24 month follow-up was examined. CHR subjects were not more frequently seropositive for neuronal autoantibodies than controls (8.3% vs. 5.2%; OR = 1.50; 95% CI: 0.58–3.90). The NMDAR was the most common target antigen and NMDAR IgGs were more sensitively detected with live versus fixed CBAs (p p p p p more...
Published: 2021
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9. Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: Findings from the EU-GEI High Risk Study

Author: Paetzold, I., Myin-Germeys, I., Schick, A., Nelson, B., Velthorst, Eva, Schirmbeck, F., Os, J., Morgan, C., Hartmann, J., van der Gaag, Mark, de Haan, Lieuwe, Valmaggia, Lucia R., McGuire, P., Kempton, Matthew J., Reininghaus, U., McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Kraan, Tamar C., Burger, Nadine, van Dam, Daniella S., Barrantes-Vidal, Neus, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R., Monsonet-Bardají, Manel, Hinojosa, Lídia, Riecher-Rössler, Anita, Borgwardt, Stefan, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Ruhrmann, Stephan, Nordholm, Dorte, Randers, Lasse, Nordentoft, Merete, Pantelis, Christos, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Psychiatrie & Neuropsychologie, Adult Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, and Amsterdam Neuroscience - Complex Trait Genetics more...
Subjects: Experience sampling method, Psychosis, Experience sampling method (ESM), Epidemiology, Ultra high risk, At-risk mental state, Affect (psychology), TRANSITION RATE, Stress sensitization, ECOLOGICAL MOMENTARY INTERVENTIONS, Surveys and Questionnaires, medicine, Humans, experience sampling method (ESM), EMOTIONAL REACTIVITY, Ecological momentary assessment (EMA), Depression (differential diagnoses), METAANALYSIS, Psychiatry, Science & Technology, Mechanism (biology), business.industry, Childhood abuse, BLACK-BOX, Public Health, Environmental and Occupational Health, childhood abuse, transition, EXPERIENCE SAMPLING RESEARCH, At risk mental state, medicine.disease, DEPRESSION, DAILY-LIFE STRESS, Psychiatry and Mental health, Psychotic Disorders, Transition, at-risk mental state, stress sensitization, ecological momentary assessment (EMA), SCHIZOPHRENIA SPECTRUM DISORDERS, Original Article, Self Report, SENSITIVITY, Stress reactivity, business, Life Sciences & Biomedicine, Stress, Psychological, Clinical psychology
Abstract: Aims Childhood trauma is associated with an elevated risk for psychosis, but the psychological mechanisms involved remain largely unclear. This study aimed to investigate emotional and psychotic stress reactivity in daily life as a putative mechanism linking childhood trauma and clinical outcomes in individuals at ultra-high-risk (UHR) for psychosis. Methods Experience sampling methodology was used to measure momentary stress, affect and psychotic experiences in the daily life of N = 79 UHR individuals in the EU-GEI High Risk Study. The Childhood Trauma Questionnaire was used to assess self-reported childhood trauma. Clinical outcomes were assessed at baseline, 1- and 2-year follow-up. Results The association of stress with positive (β = −0.14, p = 0.010) and negative affect (β = 0.11, p = 0.020) was modified by transition status such that stress reactivity was greater in individuals who transitioned to psychosis. Moreover, the association of stress with negative affect (β = 0.06, p = 0.019) and psychotic experiences (β = 0.05, p = 0.037) was greater in individuals exposed to high v. low levels of childhood trauma. We also found evidence that decreased positive affect in response to stress was associated with reduced functioning at 1-year follow-up (B = 6.29, p = 0.034). In addition, there was evidence that the association of childhood trauma with poor functional outcomes was mediated by stress reactivity (e.g. indirect effect: B = −2.13, p = 0.026), but no evidence that stress reactivity mediated the association between childhood trauma and transition (e.g. indirect effect: B = 0.14, p = 0.506). Conclusions Emotional and psychotic stress reactivity may be potential mechanisms linking childhood trauma with clinical outcomes in UHR individuals. more...
Published: 2021
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10. Brain structure changes in healthy people with childhood adversity: a meta-analysis: B52

Author: Calem, Maria, McGuire, Philip, Morgan, Craig, and Kempton, Matthew J
Published: 2014

11. Current prevalence of dementia, depression and behavioural problems in the older adult care home sector: the South East London Care Home Survey

Author: Stewart, Robert, Hotopf, Matthew, Dewey, Michael, Ballard, Clive, Bisla, Jatinder, Calem, Maria, Fahmy, Viola, Hockley, Jo, Kinley, Julie, Pearce, Hywel, Saraf, Anoop, and Begum, Aysha
Published: 2014
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12. Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis:Findings from the EU-GEI High risk study

Author: Paetzold, I., Myin-Germeys, I., Schick, A., Nelson, B., Velthorst, Eva, Schirmbeck, F., Os, J., Morgan, C., Hartmann, J., van der Gaag, Mark, de Haan, Lieuwe, Valmaggia, Lucia R., McGuire, P., Kempton, Matthew J., Reininghaus, U., McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Kraan, Tamar C., Burger, Nadine, van Dam, Daniella S., Barrantes-Vidal, Neus, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R., Monsonet-Bardají, Manel, Hinojosa, Lídia, Riecher-Rössler, Anita, Borgwardt, Stefan, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Ruhrmann, Stephan, Nordholm, Dorte, Randers, Lasse, Nordentoft, Merete, Pantelis, Christos, Paetzold, I., Myin-Germeys, I., Schick, A., Nelson, B., Velthorst, Eva, Schirmbeck, F., Os, J., Morgan, C., Hartmann, J., van der Gaag, Mark, de Haan, Lieuwe, Valmaggia, Lucia R., McGuire, P., Kempton, Matthew J., Reininghaus, U., McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Kraan, Tamar C., Burger, Nadine, van Dam, Daniella S., Barrantes-Vidal, Neus, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R., Monsonet-Bardají, Manel, Hinojosa, Lídia, Riecher-Rössler, Anita, Borgwardt, Stefan, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Ruhrmann, Stephan, Nordholm, Dorte, Randers, Lasse, Nordentoft, Merete, and Pantelis, Christos more...
Published: 2021

13. Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis

Author: Pollak, Thomas A., Kempton, Matthew J., Iyegbe, Conrad, Vincent, Angela, Irani, Sarosh R., Coutinho, Ester, Menassa, David A., Jacobson, Leslie, de Haan, Lieuwe, Ruhrmann, Stephan, Sachs, Gabriele, Riecher-Rössler, Anita, Krebs, Marie Odile, Amminger, Paul, Glenthøj, Birte, Barrantes-Vidal, Neus, van Os, Jim, Rutten, Bart P.F., Bressan, Rodrigo A., van der Gaag, Mark, Yolken, Robert, Hotopf, Matthew, Valmaggia, Lucia, Stone, James, David, Anthony S., Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Nordholm, Dorte, Randers, Lasse, Nordentoft, Merete, Pollak, Thomas A., Kempton, Matthew J., Iyegbe, Conrad, Vincent, Angela, Irani, Sarosh R., Coutinho, Ester, Menassa, David A., Jacobson, Leslie, de Haan, Lieuwe, Ruhrmann, Stephan, Sachs, Gabriele, Riecher-Rössler, Anita, Krebs, Marie Odile, Amminger, Paul, Glenthøj, Birte, Barrantes-Vidal, Neus, van Os, Jim, Rutten, Bart P.F., Bressan, Rodrigo A., van der Gaag, Mark, Yolken, Robert, Hotopf, Matthew, Valmaggia, Lucia, Stone, James, David, Anthony S., Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Nordholm, Dorte, Randers, Lasse, and Nordentoft, Merete more...
Abstract: Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic disorders. It is not known if they are present before the onset of psychosis or whether they are associated with particular clinical features or outcomes. In a case–control study, sera from 254 subjects at clinical high risk (CHR) for psychosis and 116 healthy volunteers were tested for antibodies against multiple neuronal antigens implicated in CNS autoimmune disorders, using fixed and live cell-based assays (CBAs). Within the CHR group, the relationship between NMDAR antibodies and symptoms, cognitive function and clinical outcomes over 24 month follow-up was examined. CHR subjects were not more frequently seropositive for neuronal autoantibodies than controls (8.3% vs. 5.2%; OR = 1.50; 95% CI: 0.58–3.90). The NMDAR was the most common target antigen and NMDAR IgGs were more sensitively detected with live versus fixed CBAs (p < 0.001). Preliminary phenotypic analyses revealed that within the CHR sample, the NMDAR antibody seropositive subjects had higher levels of current depression, performed worse on the Rey Auditory Verbal Learning Task (p < 0.05), and had a markedly lower IQ (p < 0.01). NMDAR IgGs were not more frequent in subjects who later became psychotic than those who did not. NMDAR antibody serostatus and titre was associated with poorer levels of functioning at follow-up (p < 0.05) and the presence of a neuronal autoantibody was associated with larger amygdala volumes (p < 0.05). Altogether, these findings demonstrate that NMDAR autoantibodies are detectable in a subgroup of CHR subjects at equal rates to controls. In the CHR group, they are associated with affective psychopathology, impairments in verbal memory, and overall cognitive function: these findings are qualitatively and individually similar to core features of autoimmune encephalitis and/or animal models of NMDAR antibody-mediated CNS disease. Ov more...
Published: 2021

14. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project

Author: Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Szöke, Andrei, Tortelli, Andrea, Llorca, Pierre Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rössler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P.F., van Os, Jim, Velthorst, Eva, de Haan, Lieuwe, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Nordholm, Dorte, Randers, Lasse, Glenthøj, Birte, Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Szöke, Andrei, Tortelli, Andrea, Llorca, Pierre Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rössler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P.F., van Os, Jim, Velthorst, Eva, de Haan, Lieuwe, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Nordholm, Dorte, Randers, Lasse, and Glenthøj, Birte more...
Published: 2021

15. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project

Author: Berendsen, Steven, primary, Kapitein, Pim, additional, Schirmbeck, Frederike, additional, van Tricht, Mirjam J., additional, McGuire, Philip, additional, Morgan, Craig, additional, Gayer-Anderson, Charlotte, additional, Kempton, Matthew J., additional, Valmaggia, Lucia, additional, Quattrone, Diego, additional, di Forti, Marta, additional, van der Gaag, Mark, additional, Kirkbride, James B., additional, Jongsma, Hannah E., additional, Jones, Peter B., additional, Parellada, Maria, additional, Arango, Celso, additional, Arrojo, Manuel, additional, Bernardo, Miguel, additional, Sanjuán, Julio, additional, Santos, José Luis, additional, Szöke, Andrei, additional, Tortelli, Andrea, additional, Llorca, Pierre-Michel, additional, Tarricone, Ilaria, additional, Tripoli, Giada, additional, Ferraro, Laura, additional, La Cascia, Caterina, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Menezes, Paulo Rossi, additional, Del-Ben, Cristina Marta, additional, Nelson, Barnaby, additional, Riecher-Rössler, Anita, additional, Bressan, Rodrigo, additional, Barrantes-Vidal, Neus, additional, Krebs, Marie-Odile, additional, Nordentoft, Merete, additional, Ruhrmann, Stephan, additional, Sachs, Gabriele, additional, Rutten, Bart P.F., additional, van Os, Jim, additional, Velthorst, Eva, additional, de Haan, Lieuwe, additional, Calem, Maria, additional, Tognin, Stefania, additional, Modinos, Gemma, additional, Pisani, Sara, additional, Kraan, Tamar C., additional, van Dam, Daniella S., additional, Burger, Nadine, additional, McGorry, Patrick, additional, Amminger, G. Paul, additional, Politis, Athena, additional, Goodall, Joanne, additional, Borgwardt, Stefan, additional, Studerus, Erich, additional, Gadelha, Ary, additional, Brietzke, Elisa, additional, Asevedo, Graccielle, additional, Asevedo, Elson, additional, Zugman, Andre, additional, Domínguez-Martínez, Tecelli, additional, Monsonet, Manel, additional, Hinojosa, Lidia, additional, Cristóbal-Narváez, Paula, additional, Racioppi, Anna, additional, Kwapil, Thomas R., additional, Kazes, Mathilde, additional, Daban, Claire, additional, Bourgin, Julie, additional, Gay, Olivier, additional, Mam-Lam-Fook, Célia, additional, Nordholm, Dorte, additional, Randers, Lasse, additional, Krakauer, Kristine, additional, Glenthøj, Louise Birkedal, additional, Glenthøj, Birte, additional, Gebhard, Dominika, additional, Arnhold, Julia, additional, Klosterkötter, Joachim, additional, Lasser, Iris, additional, Winklbaur, Bernadette, additional, and Delespaul, Philippe A., additional more...
Published: 2021
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16. Dysregulated Lipid Metabolism Precedes Onset of Psychosis

Author: Dickens, Alex M., primary, Sen, Partho, additional, Kempton, Matthew J., additional, Barrantes-Vidal, Neus, additional, Iyegbe, Conrad, additional, Nordentoft, Merete, additional, Pollak, Thomas, additional, Riecher-Rössler, Anita, additional, Ruhrmann, Stephan, additional, Sachs, Gabriele, additional, Bressan, Rodrigo, additional, Krebs, Marie-Odile, additional, Amminger, G. Paul, additional, de Haan, Lieuwe, additional, van der Gaag, Mark, additional, Valmaggia, Lucia, additional, Hyötyläinen, Tuulia, additional, Orešič, Matej, additional, McGuire, Philip, additional, Valmaggia, Lucia R., additional, Calem, Maria, additional, Tognin, Stefania, additional, Modinos, Gemma, additional, Velthorst, Eva, additional, Kraan, Tamar C., additional, van Dam, Daniella S., additional, Burger, Nadine, additional, Nelson, Barnaby, additional, McGorry, Patrick, additional, Pantelis, Christos, additional, Politis, Athena, additional, Goodall, Joanne, additional, Borgwardt, Stefan, additional, Rapp, Charlotte, additional, Ittig, Sarah, additional, Studerus, Erich, additional, Smieskova, Renata, additional, Gadelha, Ary, additional, Brietzke, Elisa, additional, Asevedo, Graccielle, additional, Asevedo, Elson, additional, Zugman, Andre, additional, Domínguez-Martínez, Tecelli, additional, Racciopi, Anna, additional, Kwapil, Thomas R., additional, Monsonet, Manel, additional, Rosa, Araceli, additional, Frajerman, Ariel, additional, Chaumette, Boris, additional, Bourgin, Julie, additional, Kebir, Oussama, additional, Jantac, Célia, additional, Nordholm, Dorte, additional, Randers, Lasse, additional, Krakauer, Kristine, additional, Glenthøj, Louise, additional, Glenthøj, Birte, additional, Gebhard, Dominika, additional, Arnhold, Julia, additional, Klosterkötter, Joachim, additional, Lasser, Iris, additional, Winklbaur, Bernadette, additional, Delespaul, Philippe A., additional, Rutten, Bart P., additional, and van Os, Jim, additional more...
Published: 2021
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17. Criminal offending and distinguishing features of offenders among persons experiencing a first episode of psychosis

Author: Hodgins, Sheilagh, Calem, Maria, Shimel, Rhiannon, Williams, Andrew, Harleston, Dionne, Morgan, Craig, Dazzan, Paola, Fearon, Paul, Morgan, Kevin, Lappin, Julia, Zanelli, Jolanta, Reichenberg, Abraham, and Jones, Peter more...
Published: 2011
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18. Have we forgotten about dementia in care homes? The importance of maintaining survey research in this sector

Author: Bisla, Jatinder, Calem, Maria, Begum, Aysha, and Stewart, Robert
Published: 2011
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19. Child Maltreatment and Clinical Outcome in Individuals at Ultra-High Risk for Psychosis in the EU-GEI High Risk Study

Author: Kraan, Tamar C., Velthorst, Eva, Themmen, Manouk, Valmaggia, Lucia, Kempton, Matthew J., McGuire, Phillip, Van Os, Jim, Rutten, Bart P.F., Smit, Filip, De Haan, Lieuwe, Van Der Gaag, Mark, McGuire, Philip, Valmaggia, Lucia R., Calem, Maria, Tognin, Stefania, Modinos, Gemma, Burger, Nadine, Van Dam, Daniella S., Barrantes-Vidal, Neus, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R., Monsonet-Bardají, Manel, Hinojosa, Lídia, Riecher-Rössler, Anita, Borgwardt, Stefan, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Ruhrmann, Stephan, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Naumann, Tanya Louise, Glenthøj, Louise Birkedal, Nordentoft, Merete, De Hert, Marc, Van Winkel, Ruud, Nelson, Barnaby, McGorry, Patrick, Clinical Psychology, APH - Mental Health, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, and Epidemiology and Data Science more...
Subjects: Male, Child abuse, INCREASES, clinical outcome, Poison control, Stress Disorders, Post-Traumatic, 0302 clinical medicine, Risk Factors, SCHIZOPHRENIA, Child Abuse, psychosis, Psychological abuse, ultra high risk, Adult Survivors of Child Abuse, PSYCHOPATHOLOGY, Justice and Strong Institutions, Europe, Psychiatry and Mental health, Schizophrenia, Panic Disorder, Female, Psychology, TRANSITION, Psychopathology, Clinical psychology, Adult, medicine.medical_specialty, Psychosis, SDG 16 - Peace, LIFE EVENTS, Adolescent, DISORDERS, Young Adult, 03 medical and health sciences, medicine, Humans, COHORT, Risk factor, Psychiatry, METAANALYSIS, Depressive Disorder, Panic disorder, SDG 16 - Peace, Justice and Strong Institutions, Phobia, Social, medicine.disease, 030227 psychiatry, CONVERSION, Psychotic Disorders, child maltreatment, TRAUMATIC EXPERIENCES, 030217 neurology & neurosurgery, Regular Articles, Follow-Up Studies
Abstract: Background: Child maltreatment has been associated with a wide range of mental disorders in adulthood. Whether child maltreatment is specifically associated with psychosis risk in individuals at ultra-high risk (UHR) for psychosis, or leads to a general vulnerability for overall psychopathology in the UHR stage remains unclear. The present study examines the association between child maltreatment and transition to psychosis and other mental disorders. Methods: The sample consisted of 259 UHR individuals from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Participants were followed-up for 2 years to assess clinical outcome. Clinical outcome was assessed at 6 months, 12 months, and 24 months after baseline. Child maltreatment before the age of 17 years was assessed at baseline. Results: Our findings show that a history of emotional abuse was associated with an increased risk for transition to psychosis (OR = 3.78, 95% CI = 1.17 to 12.39, P = -027). Apart from psychosis, a history of physical abuse was associated with depressive disorder (OR = 4.92, 95% CI = 2.12 to 11.39, P = .001), post-traumatic stress disorder (OR = 2.06, 95% CI = 1.10 to 3.86, P = .023), panic disorder (OR = 2.00, 95% CI = 1.00 to 3.99, P = .048) and social phobia (OR = 2.47, 95% CI = 1.18 to 5.16, P = .016) at follow-up. Conclusion: Our findings suggest that in the UHR stage child maltreatment is a pluripotent risk factor for developing psychosis, depressive disorder, post-traumatic stress disorder (PTSD), panic disorder, and social phobia in adulthood. more...
Published: 2017
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20. From Speech Illusions to Onset of Psychotic Disorder: Applying Network Analysis to an Experimental Measure of Aberrant Experiences

Author: Boyette, Lindy-Lou, Isvoranu, Adela-Maria, Schirmbeck, Frederike, Velthorst, Eva, Simons, Claudia J P, Barrantes-Vidal, Neus, Bressan, Rodrigo, Kempton, Matthew J, Krebs, Marie-Odile, McGuire, Philip, Nelson, Barnaby, Nordentoft, Merete, Riecher-Rössler, Anita, Ruhrmann, Stephan, Rutten, Bart P, Sachs, Gabriele, Valmaggia, Lucia R, van der Gaag, Mark, Borsboom, Denny, de Haan, Lieuwe, van Os, Jim, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Kraan, Tamar C, van Dam, Daniella S, Burger, Nadine, McGorry, Patrick, Amminger, G Paul, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R, Monsonet, Manel, Hinojosa, Lídia, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Célia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise, Glenthøj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A, Klinische Psychologie (Psychologie, FMG), and Psychologische Methodenleer (Psychologie, FMG) more...
Subjects: Psychosis, media_common.quotation_subject, Illusion, Network structure, Ideation, Affect (psychology), medicine.disease, 030227 psychiatry, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, medicine, In patient, Psychology, 030217 neurology & neurosurgery, Depression (differential diagnoses), Network approach, Clinical psychology, media_common
Abstract: Aberrant perceptional experiences are a potential early marker of psychosis development. Earlier studies have found experimentally assessed speech illusions to be associated with positive symptoms in patients with psychotic disorders, but findings for attenuated symptoms in individuals without psychotic disorders have been inconsistent. Also, the role of affect is unclear. The aim of this study was to use the network approach to investigate how speech illusions relate to individual symptoms and onset of a psychotic disorder. We estimated a network model based on data from 289 Clinical High-Risk (CHR) subjects, participating in the EU-GEI project. The network structure depicts statistical associations between (affective and all) speech illusions, cross-sectional individual attenuated positive and affective symptoms, and transition to psychotic disorder after conditioning on all other variables in the network. Speech illusions were assessed with the White Noise Task, symptoms with the BPRS and transition during 24-month follow-up with the CAARMS. Affective, not all, speech illusions were found to be directly, albeit weakly, associated with hallucinatory experiences. Hallucinatory experiences, in turn, were associated with delusional ideation. Bizarre behavior was the only symptom in the network steadily predictive of transition. Affective symptoms were highly interrelated, with depression showing the highest overall strength of connections to and predictability by other symptoms. Both speech illusions and transition showed low overall predictability by symptoms. Our findings suggest that experimentally assessed speech illusions are not a mere consequence of psychotic symptoms or disorder, but that their single assessment is likely not useful for assessing transition risk. more...
Published: 2020

21. Association of Adverse Outcomes With Emotion Processing and Its Neural Substrate in Individuals at Clinical High Risk for Psychosis

Author: Modinos, Gemma, Kempton, Matthew J, Tognin, Stefania, Calem, Maria, Porffy, Lilla, Antoniades, Mathilde, Mason, Ava, Azis, Matilda, Allen, Paul, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Riecher-Rossler, Anita, Borgwardt, Stefan, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Glenthoj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart, van Os, Jim, de Haan, Lieuwe, Velthorst, Eva, van der Gaag, Mark, Valmaggia, Lucia R, McGuire, Philip, Kraan, Tamar C, van Dam, Daniella S, Burger, Nadine, Amminger, G Paul, Politis, Athena, Goodall, Joanne, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Dominguez-Martinez, Tecelli, Monsonet, Manel, Hinojosa, Lidia, Racioppi, Anna, Kwapil, Thomas R, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise Birkedal, Gebhard, Dominika, Arnhold, Julia, Klosterkotter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A, MUMC+: MA Psychiatrie (3), Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, RS: MHeNs - R2 - Mental Health, Adult Psychiatry, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, King‘s College London, University of Roehampton, United Kingdom, University of Melbourne, University of Copenhagen = Københavns Universitet (KU), University of Basel (Unibas), Universidade Federal de São Paulo-Escola Paulista de Medicina [Brazil] (UNIFESP-EPM), Universitat Autònoma de Barcelona (UAB), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), University of Cologne, Medizinische Universität Wien = Medical University of Vienna, Maastricht University [Maastricht], University Medical Center [Utrecht], Amsterdam UMC, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Vrije Universiteit Amsterdam [Amsterdam] (VU), Parnassia Psychiatric Institute [The Hague], South London and Maudsley NHS Foundation Trust, EU-GEI High Risk Study Group, University of Copenhagen = Københavns Universitet (UCPH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Amsterdam UMC - Amsterdam University Medical Center, Martinez Rico, Clara, and Clinical Psychology more...
Subjects: Male, Global Assessment of Functioning, Emotions, Psychological intervention, FEARFUL FACES, PREFRONTAL CORTEX, 0302 clinical medicine, SCHIZOPHRENIA, Young adult, Gray Matter, Emotional Intelligence, Psychiatry, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Socioemotional selectivity theory, Brain, Magnetic Resonance Imaging, NEUTRAL FACES, 3. Good health, Psychiatry and Mental health, SOCIAL COGNITION, Female, Life Sciences & Biomedicine, Facial Recognition, Clinical psychology, Psychosis, longitudinal, Bipolar disorder, Neuroimaging, functioning, 03 medical and health sciences, Young Adult, medicine, trajectories, Humans, GRAY-MATTER VOLUME, METAANALYSIS, Psychiatric Status Rating Scales, Science & Technology, business.industry, Case-control study, RECOGNITION, prediction, medicine.disease, 030227 psychiatry, Psychotic Disorders, ULTRA-HIGH RISK, Case-Control Studies, ONSET, business, Insula, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Ajuts: Project is funded by grant agreement HEALTH-F2-2010-241909 (Project EU-GEI) from the European Community Seventh Framework Programme. Additional financial support was obtained from the Institut National de la Santé et de la Recherche Médicale (recurrent funding and fellowships) and by Fondation Pierre Deniker. The study received grant 08-MNP-007 from the French government Agence Nationale de la Recherche and grant AOM-07-118 (Influence of Cannabis Psychopathological Outcome in At-risk Mental State [ICAAR study]) from the French Health Ministry Programme Hospitalier de Recherche Clinique. The Sainte-Anne Hospital Center promoted the study. Dr Kempton was supported by a Medical Research Council Fellowship grant MR/J008915/1. Dr Pantelis was supported by Australia's National Health and Medical Research Council Senior Principal Research Fellowship (ID: 628386 & 1105825) and by grant R246-2016-3237 from the Lundbeck Foundation. Dr Barrantes-Vidal was supported by the Ministerio de Ciencia, Innovación e Universidades (PSI2017-87512-C2-1-R), and the Generalitat de Catalunya (2017SGR1612 and ICREA Academia Award). Dr Modinos was supported by a Sir Henry Dale Fellowship #202397/Z/16/Z, jointly funded by The Wellcome Trust and the Royal Society. This case-control study analyzes emotion recognition and neuroimaging data as well as clinical and functional outcomes for individuals at risk for transition to psychosis and those without psychiatric or neurological disorders. Is altered emotion recognition associated with adverse clinical and functional outcomes in people at clinical high risk for psychosis? In this case-control study of 213 individuals at clinical high risk for psychosis and 52 healthy participants, abnormalities in the recognition of negative emotion at baseline were associated with neuroanatomical alterations in the medial prefrontal cortex and hippocampus and with a low level of functioning at a 12-month follow-up. This study found that, in people with high risk for developing psychosis, functional outcomes are associated with the degree to which their emotion processing is altered. The development of adverse clinical outcomes in patients with psychosis has been associated with behavioral and neuroanatomical deficits related to emotion processing. However, the association between alterations in brain regions subserving emotion processing and clinical outcomes remains unclear. To examine the association between alterations in emotion processing and regional gray matter volumes in individuals at clinical high risk (CHR) for psychosis, and the association with subsequent clinical outcomes. This naturalistic case-control study with clinical follow-up at 12 months was conducted from July 1, 2010, to August 31, 2016, and collected data from 9 psychosis early detection centers (Amsterdam, Basel, Cologne, Copenhagen, London, Melbourne, Paris, The Hague, and Vienna). Participants (213 individuals at CHR and 52 healthy controls) were enrolled in the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) project. Data were analyzed from October 1, 2018, to April 24, 2019. Emotion recognition was assessed with the Degraded Facial Affect Recognition Task. Three-Tesla magnetic resonance imaging scans were acquired from all participants, and gray matter volume was measured in regions of interest (medial prefrontal cortex, amygdala, hippocampus, and insula). Clinical outcomes at 12 months were evaluated for transition to psychosis using the Comprehensive Assessment of At-Risk Mental States criteria, and the level of overall functioning was measured through the Global Assessment of Functioning [GAF] scale. A total of 213 individuals at CHR (105 women [49.3%]; mean [SD] age, 22.9 [4.7] years) and 52 healthy controls (25 women [48.1%]; mean [SD] age, 23.3 [4.0] years) were included in the study at baseline. At the follow-up within 2 years of baseline, 44 individuals at CHR (20.7%) had developed psychosis and 169 (79.3%) had not. Of the individuals at CHR reinterviewed with the GAF, 39 (30.0%) showed good overall functioning (GAF score, ≥65), whereas 91 (70.0%) had poor overall functioning (GAF score more...
Published: 2019
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22. Basic Self-Disturbances Related to Reduced Anterior Cingulate Volume in Subjects at Ultra-High Risk for Psychosis

Author: Bonoldi, Ilaria, Allen, Paul, Madeira, Luis, Tognin, Stefania, Bossong, Matthijs G, Azis, Mathilda, Samson, Carly, Quinn, Beverly, Calem, Maria, Valmaggia, Lucia, Modinos, Gemma, Stone, James, Perez, Jesus, Howes, Oliver, Politi, Pierluigi, Kempton, Matthew J, Fusar-Poli, Paolo, and McGuire, Philip more...
Subjects: Psychiatry, CORTEX, Science & Technology, Ultra-high risk, DISORDERS, SCHIZOPHRENIA INTEGRATING PHENOMENOLOGY, Voxel-based morphometry, Psychosis, Self-disturbances, INDIVIDUALS, Psychiatry and Mental health, WORKING-MEMORY, Magnetic resonance imaging, ONSET, MENTAL STATE, Journal Article, Schizophrenia, EXPERIENCE, sense organs, CLINICAL HIGH-RISK, BRAIN, Life Sciences & Biomedicine
Abstract: Introduction: Alterations of the "pre-reflective" sense of first-person perspective (e.g., of the "basic self") are characteristic features of schizophrenic spectrum disorders and are significantly present in the prodromal phase of psychosis and in subjects at ultra-high risk for psychosis (UHR). Studies in healthy controls suggest that neurobiological substrate of the basic self involves cortical midline structures, such as the anterior and posterior cingulate cortices. Neuroimaging studies have identified neuroanatomical cortical midline structure abnormalities in schizophrenic spectrum disorders. Objectives: i) To compare basic self-disturbances levels in UHR subjects and controls and ii) to assess the relationship between basic self-disturbances and alterations in cortical midline structures volume in UHR subjects. Methods: Thirty-one UHR subjects (27 antipsychotic-naïve) and 16 healthy controls were assessed using the 57-item semistructured Examination of Anomalous Self-Experiences (EASE) interview. All subjects were scanned using magnetic resonance imaging (MRI) at 3 T, and gray matter volume was measured in a priori defined regions of interest (ROIs) in the cortical midline structures. Results: EASE scores were much higher in UHR subjects than controls (p < 0.001). The UHR group had smaller anterior cingulate volume than controls (p = 0.037). There were no structural brain imaging alterations between UHR individuals with or without self-disturbances. Within the UHR sample, the subgroup with higher EASE scores had smaller anterior cingulate volumes than UHR subjects with lower EASE scores and controls (p = 0.018). In the total sample, anterior cingulate volume was inversely correlated with the EASE score (R = 0.52, p < 0.016). Conclusions: Basic self-disturbances in UHR subjects appear to be related to reductions in anterior cingulate volume. ispartof: FRONTIERS IN PSYCHIATRY vol:10 ispartof: location:Switzerland status: published more...
Published: 2019
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23. Association of Adverse Outcomes With Emotion Processing and Its Neural Substrate in Individuals at Clinical High Risk for Psychosis

Author: Modinos, Gemma, Kempton, Matthew J., Tognin, Stefania, Calem, Maria, Porffy, Lilla, Antoniades, Mathilde, Mason, Ava, Azis, Matilda, Allen, Paul, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Riecher-Rossler, Anita, Borgwardt, Stefan, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Glenthoj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart, van Os, Jim, de Haan, Lieuwe, Velthorst, Eva, van der Gaag, Mark, Valmaggia, Lucia R., McGuire, Philip, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Dominguez-Martinez, Tecelli, Monsonet, Manel, Hinojosa, Lidia, Racioppi, Anna, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise Birkedal, Gebhard, Dominika, Arnhold, Julia, Klosterkotter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., Modinos, Gemma, Kempton, Matthew J., Tognin, Stefania, Calem, Maria, Porffy, Lilla, Antoniades, Mathilde, Mason, Ava, Azis, Matilda, Allen, Paul, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Riecher-Rossler, Anita, Borgwardt, Stefan, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Glenthoj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart, van Os, Jim, de Haan, Lieuwe, Velthorst, Eva, van der Gaag, Mark, Valmaggia, Lucia R., McGuire, Philip, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Dominguez-Martinez, Tecelli, Monsonet, Manel, Hinojosa, Lidia, Racioppi, Anna, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise Birkedal, Gebhard, Dominika, Arnhold, Julia, Klosterkotter, Joachim, Lasser, Iris, Winklbaur, Bernadette, and Delespaul, Philippe A. more...
Abstract: This case-control study analyzes emotion recognition and neuroimaging data as well as clinical and functional outcomes for individuals at risk for transition to psychosis and those without psychiatric or neurological disorders. Question Is altered emotion recognition associated with adverse clinical and functional outcomes in people at clinical high risk for psychosis? Findings In this case-control study of 213 individuals at clinical high risk for psychosis and 52 healthy participants, abnormalities in the recognition of negative emotion at baseline were associated with neuroanatomical alterations in the medial prefrontal cortex and hippocampus and with a low level of functioning at a 12-month follow-up. Meaning This study found that, in people with high risk for developing psychosis, functional outcomes are associated with the degree to which their emotion processing is altered. Importance The development of adverse clinical outcomes in patients with psychosis has been associated with behavioral and neuroanatomical deficits related to emotion processing. However, the association between alterations in brain regions subserving emotion processing and clinical outcomes remains unclear. Objective To examine the association between alterations in emotion processing and regional gray matter volumes in individuals at clinical high risk (CHR) for psychosis, and the association with subsequent clinical outcomes. Design, Setting, and Participants This naturalistic case-control study with clinical follow-up at 12 months was conducted from July 1, 2010, to August 31, 2016, and collected data from 9 psychosis early detection centers (Amsterdam, Basel, Cologne, Copenhagen, London, Melbourne, Paris, The Hague, and Vienna). Participants (213 individuals at CHR and 52 healthy controls) were enrolled in the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) project. Data were analyzed from October 1, 2018, to April 24, 2019. Main Mea more...
Published: 2020

24. O6.5. INVESTIGATING VARIABLES FROM THE NAPLS RISK CALCULATOR FOR PSYCHOSIS IN THE EU-GEI HIGH RISK STUDY

Author: Kempton, Matthew, primary, Valmaggia, Lucia, additional, Calem, Maria, additional, Tognin, Stefania, additional, Modinos, Gemma, additional, Fusar-poli, Paolo, additional, Antoniades, Mathilde, additional, Van der Gaag, Mark, additional, Haan, Lieuwe De, additional, Nelson, Barnaby, additional, Riecher-Rössler, Anita, additional, Bressan, Rodrigo, additional, Barrantes-Vidal, Neus, additional, Krebs, Marie-Odile, additional, Nordentoft, Merete, additional, Ruhrmann, Stephan, additional, Sachs, Gabriele, additional, Rutten, Bart, additional, Os, Jim Van, additional, McGuire, Philip, additional, WP, EU-GEI, additional, and Study, High Risk, additional more...
Published: 2019
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25. Gender differences of patients at-risk for psychosis regarding symptomatology, drug use, comorbidity and functioning - Results from the EU-GEI study

Author: Menghini-Mueller, Stephanie, Studerus, Erich, Ittig, Sarah, Heitz, Ulrike, Egloff, Laura, Andreou, Christina, Valmaggia, Lucia R., Kempton, Matthew J., van der Gaag, Mark, de Haan, Lieuwe, Nelson, Barnaby, Barrantes-Vidal, Neus, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P., van Os, Jim, Riecher-Rossler, Anita, McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, McGorry, Patrick, Amminger, G. Paul, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Rapp, Charlotte, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Dominguez-Martinez, Tecelli, Racioppi, Anna, Cristobal-Narvaez, Paula, Kwapil, Thomas R., Monsonet, Manel, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Krebs, Marie-Odile, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise, Glenthoj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkotter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespau, Philippe A., Menghini-Mueller, Stephanie, Studerus, Erich, Ittig, Sarah, Heitz, Ulrike, Egloff, Laura, Andreou, Christina, Valmaggia, Lucia R., Kempton, Matthew J., van der Gaag, Mark, de Haan, Lieuwe, Nelson, Barnaby, Barrantes-Vidal, Neus, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P., van Os, Jim, Riecher-Rossler, Anita, McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, McGorry, Patrick, Amminger, G. Paul, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Rapp, Charlotte, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Dominguez-Martinez, Tecelli, Racioppi, Anna, Cristobal-Narvaez, Paula, Kwapil, Thomas R., Monsonet, Manel, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Krebs, Marie-Odile, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise, Glenthoj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkotter, Joachim, Lasser, Iris, Winklbaur, Bernadette, and Delespau, Philippe A. more...
Published: 2019

26. Basic Self-Disturbances Related to Reduced Anterior Cingulate Volume in Subjects at Ultra-High Risk for Psychosis

Author: Onderzoeksgroep 1, Brain, Bonoldi, Ilaria, Allen, Paul, Madeira, Luis, Tognin, Stefania, Bossong, Matthijs G, Azis, Mathilda, Samson, Carly, Quinn, Beverly, Calem, Maria, Valmaggia, Lucia, Modinos, Gemma, Stone, James, Perez, Jesus, Howes, Oliver, Politi, Pierluigi, Kempton, Matthew J, Fusar-Poli, Paolo, McGuire, Philip, Onderzoeksgroep 1, Brain, Bonoldi, Ilaria, Allen, Paul, Madeira, Luis, Tognin, Stefania, Bossong, Matthijs G, Azis, Mathilda, Samson, Carly, Quinn, Beverly, Calem, Maria, Valmaggia, Lucia, Modinos, Gemma, Stone, James, Perez, Jesus, Howes, Oliver, Politi, Pierluigi, Kempton, Matthew J, Fusar-Poli, Paolo, and McGuire, Philip more...
Published: 2019

27. Meta-Analysis of 89 Structural MRI Studies in Posttraumatic Stress Disorder and Comparison With Major Depressive Disorder

Author: Bromis, Konstantinos, primary, Calem, Maria, additional, Reinders, Antje A.T.S., additional, Williams, Steven C.R., additional, and Kempton, Matthew J., additional
Published: 2018
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28. Increased Resting Hippocampal and Basal Ganglia Perfusion in People at Ultra High Risk for Psychosis : Replication in a Second Cohort

Author: Allen, Paul, Azis, Matilda, Modinos, Gemma, Bossong, MG, Bonoldi, Ilaria, Samson, Carly, Quinn, Beverly, Kempton, Matthew, Howes, Oliver, Stone, James, Calem, Maria, Perez, Jesus, Bhattacharyya, Sagnik, Broome, Matthew, Grace, Anthony, Zelaya, Fernando, McGuire, Philip, Allen, Paul, Azis, Matilda, Modinos, Gemma, Bossong, MG, Bonoldi, Ilaria, Samson, Carly, Quinn, Beverly, Kempton, Matthew, Howes, Oliver, Stone, James, Calem, Maria, Perez, Jesus, Bhattacharyya, Sagnik, Broome, Matthew, Grace, Anthony, Zelaya, Fernando, and McGuire, Philip more...
Published: 2018

29. Child Maltreatment and Clinical Outcome in Individuals at Ultra-High Risk for Psychosis in the EU-GEI High Risk Study

Author: Kraan, Tamar C., Velthorst, Eva, Themmen, Manouk, Valmaggia, Lucia, Kempton, Matthew J., McGuire, Phillip, Van Os, Jim, Rutten, Bart P.F., Smit, Filip, De Haan, Lieuwe, Van Der Gaag, Mark, McGuire, Philip, Valmaggia, Lucia R., Calem, Maria, Tognin, Stefania, Modinos, Gemma, Burger, Nadine, Van Dam, Daniella S., Barrantes-Vidal, Neus, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R., Monsonet-Bardají, Manel, Hinojosa, Lídia, Riecher-Rössler, Anita, Borgwardt, Stefan, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Ruhrmann, Stephan, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Naumann, Tanya Louise, Glenthøj, Louise Birkedal, Nordentoft, Merete, De Hert, Marc, Van Winkel, Ruud, Nelson, Barnaby, McGorry, Patrick, EU-GEI High Risk Study, Kraan, Tamar C., Velthorst, Eva, Themmen, Manouk, Valmaggia, Lucia, Kempton, Matthew J., McGuire, Phillip, Van Os, Jim, Rutten, Bart P.F., Smit, Filip, De Haan, Lieuwe, Van Der Gaag, Mark, McGuire, Philip, Valmaggia, Lucia R., Calem, Maria, Tognin, Stefania, Modinos, Gemma, Burger, Nadine, Van Dam, Daniella S., Barrantes-Vidal, Neus, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R., Monsonet-Bardají, Manel, Hinojosa, Lídia, Riecher-Rössler, Anita, Borgwardt, Stefan, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Ruhrmann, Stephan, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Naumann, Tanya Louise, Glenthøj, Louise Birkedal, Nordentoft, Merete, De Hert, Marc, Van Winkel, Ruud, Nelson, Barnaby, McGorry, Patrick, and EU-GEI High Risk Study more...
Abstract: Background: Child maltreatment has been associated with a wide range of mental disorders in adulthood. Whether child maltreatment is specifically associated with psychosis risk in individuals at ultra-high risk (UHR) for psychosis, or leads to a general vulnerability for overall psychopathology in the UHR stage remains unclear. The present study examines the association between child maltreatment and transition to psychosis and other mental disorders. Methods: The sample consisted of 259 UHR individuals from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Participants were followed-up for 2 years to assess clinical outcome. Clinical outcome was assessed at 6 months, 12 months, and 24 months after baseline. Child maltreatment before the age of 17 years was assessed at baseline. Results: Our findings show that a history of emotional abuse was associated with an increased risk for transition to psychosis (OR = 3.78, 95% CI = 1.17 to 12.39, P = -027). Apart from psychosis, a history of physical abuse was associated with depressive disorder (OR = 4.92, 95% CI = 2.12 to 11.39, P = .001), post-traumatic stress disorder (OR = 2.06, 95% CI = 1.10 to 3.86, P = .023), panic disorder (OR = 2.00, 95% CI = 1.00 to 3.99, P = .048) and social phobia (OR = 2.47, 95% CI = 1.18 to 5.16, P = .016) at follow-up. Conclusion: Our findings suggest that in the UHR stage child maltreatment is a pluripotent risk factor for developing psychosis, depressive disorder, post-traumatic stress disorder (PTSD), panic disorder, and social phobia in adulthood. more...
Published: 2018
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30. Increased Resting Hippocampal and Basal Ganglia Perfusion in People at Ultra High Risk for Psychosis: Replication in a Second Cohort

Author: Brain, Onderzoeksgroep 1, Onderzoeksgroep 9, Allen, Paul, Azis, Matilda, Modinos, Gemma, Bossong, MG, Bonoldi, Ilaria, Samson, Carly, Quinn, Beverly, Kempton, Matthew, Howes, Oliver, Stone, James, Calem, Maria, Perez, Jesus, Bhattacharyya, Sagnik, Broome, Matthew, Grace, Anthony, Zelaya, Fernando, McGuire, Philip, Brain, Onderzoeksgroep 1, Onderzoeksgroep 9, Allen, Paul, Azis, Matilda, Modinos, Gemma, Bossong, MG, Bonoldi, Ilaria, Samson, Carly, Quinn, Beverly, Kempton, Matthew, Howes, Oliver, Stone, James, Calem, Maria, Perez, Jesus, Bhattacharyya, Sagnik, Broome, Matthew, Grace, Anthony, Zelaya, Fernando, and McGuire, Philip more...
Published: 2018

31. Increased Resting Hippocampal and Basal Ganglia Perfusion in People at Ultra High Risk for Psychosis: Replication in a Second Cohort

Author: Allen, Paul, primary, Azis, Matilda, additional, Modinos, Gemma, additional, Bossong, Matthijs G, additional, Bonoldi, Ilaria, additional, Samson, Carly, additional, Quinn, Beverly, additional, Kempton, Matthew J, additional, Howes, Oliver D, additional, Stone, James M, additional, Calem, Maria, additional, Perez, Jesus, additional, Bhattacharayya, Sagnik, additional, Broome, Matthew R, additional, Grace, Anthony A, additional, Zelaya, Fernando, additional, and McGuire, Philip, additional more...
Published: 2017
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32. Basic Self-Disturbances Related to Reduced Anterior Cingulate Volume in Subjects at Ultrahigh Risk for Psychosis.

Author: Bonoldi, Ilaria, Allen, Paul, Madeira, Luis, Tognin, Stefania, Bossong, Matthijs G., Azis, Mathilda, Samson, Carly, Quinn, Beverly, Calem, Maria, Valmaggia, Lucia, Modinos, Gemma, Stone, James, Perez, Jesus, Howes, Oliver, Politi, Pierluigi, Kempton, Matthew J., Fusar-Poli, Paolo, and McGuire, Philip more...
Subjects: PSYCHOSES, CINGULATE cortex, SCHIZOPHRENIA, BRAIN imaging, ANTIPSYCHOTIC agents, MAGNETIC resonance imaging
Abstract: Introduction: Alterations of the "pre-reflective" sense of first-person perspective (e.g., of the "basic self") are characteristic features of schizophrenic spectrum disorders and are significantly present in the prodromal phase of psychosis and in subjects at ultrahigh risk for psychosis (UHR). Studies in healthy controls suggest that neurobiological substrate of the basic self involves cortical midline structures, such as the anterior and posterior cingulate cortices. Neuroimaging studies have identified neuroanatomical cortical midline structure abnormalities in schizophrenic spectrum disorders. Objectives: i) To compare basic self-disturbances levels in UHR subjects and controls and ii) to assess the relationship between basic self-disturbances and alterations in cortical midline structures volume in UHR subjects. Methods: Thirty-one UHR subjects (27 antipsychotic-naïve) and 16 healthy controls were assessed using the 57-item semistructured Examination of Anomalous Self-Experiences (EASE) interview. All subjects were scanned using magnetic resonance imaging (MRI) at 3 T, and gray matter volume was measured in a priori defined regions of interest (ROIs) in the cortical midline structures. Results: EASE scores were much higher in UHR subjects than controls (p < 0.001). The UHR group had smaller anterior cingulate volume than controls (p = 0.037). There were no structural brain imaging alterations between UHR individuals with or without self-disturbances. Within the UHR sample, the subgroup with higher EASE scores had smaller anterior cingulate volumes than UHR subjects with lower EASE scores and controls (p = 0.018). In the total sample, anterior cingulate volume was inversely correlated with the EASE score (R = 0.52, p < 0.016). Conclusions: Basic self-disturbances in UHR subjects appear to be related to reductions in anterior cingulate volume. [ABSTRACT FROM AUTHOR] more...
Published: 2019
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33. SA92. Trauma, Stress, and the Hippocampus in the At-Risk Mental State

Author: Calem, Maria, primary, Reininghaus, Ulrich, additional, Valmaggia, Lucia, additional, Nelson, Barnaby, additional, Velthorst, Eva, additional, Myin-Germeys, Inez, additional, Morgan, Craig, additional, McGuire, Philip, additional, and Kempton, Matthew, additional more...
Published: 2017
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34. M122. Impact of Childhood Trauma on Educational Achievement in Young People at Clinical High Risk of Psychosis

Author: Tognin, Stefania, primary and Calem, Maria, additional
Published: 2017
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35. Neuroanatomical correlates of HPA axis biomarkers among children at elevated risk for schizophrenia

Author: Cullen, Alexis, Sagar, Sajani, Calem, Maria, Roberts, Ruth, Kempton, Matthew, Pariante, Carmine, Fisher, Helen, Zunszain, Patricia, Laurens, Kristin, Cullen, Alexis, Sagar, Sajani, Calem, Maria, Roberts, Ruth, Kempton, Matthew, Pariante, Carmine, Fisher, Helen, Zunszain, Patricia, and Laurens, Kristin more...
Abstract: Background: The hypothalamic-pituitary-adrenal (HPA) axis disturbances observed in psychosis might feasibly contribute to some of the structural brain abnormalities associated with the disorder (i.e., via the potentially toxic effects of elevated glucocorticoid levels on the brain). However, the association between brain structure and cortisol has rarely been investigated. The current study examined relationships between salivary cortisol and regional brain volumes among at-risk children aged 11-14 years, who present multiple antecedents of schizophrenia (ASz=30) or a family history of illness (FHx=22), and typically-developing children (TD=32). Methods: Volumes of specific brain regions known to express glucocorticoid receptors were extracted from structural brain images using FreeSurfer. Diurnal cortisol levels and the cortisol awakening response (CAR) were determined from multiple salivary cortisol samples obtained throughout the day. Results: In the FHx group only, higher diurnal cortisol was correlated with smaller right amygdala and white matter hypointensity volumes (r=-0.51 and -0.62, respectively, p<0.05). In post-hoc analyses, a higher CAR was associated with smaller bilateral cerebellum, bilateral hippocampus, right ventral diencephalon, and total subcortical grey matter volumes among FHx children with a first-degree relative with schizophrenia. In FHx children with an affected second-degree relative, increased diurnal cortisol levels were associated with smaller left hippocampal and white matter hypointensity volumes. Conclusions: Our findings are consistent with the few previous studies examining cortisol and brain structure among adults with established psychosis. These associations may not necessarily reflect a direct effect of cortisol on the developing brain; indeed, abnormal neurodevelopment affecting these brain regions may contribute to HPA-axis dysregulation. Funding: This work was supported by a Sir Henry Well more...
Published: 2016

36. Identifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations

Author: van Os, Jim, Rutten, Bart P., Myin-Germeys, Inez, Delespaul, Philippe, Viechtbauer, Wolfgang, van Zelst, Catherine, Bruggeman, Richard, Reininghaus, Ulrich, Morgan, Craig, Murray, Robin M., Di Forti, Marta, McGuire, Philip, Valmaggia, Lucia R., Kempton, Matthew J., Gayer-Anderson, Charlotte, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Onyejiaka, Adanna, Bourque, Francois, Modinos, Gemma, Tognin, Stefania, Calem, Maria, O'Donovan, Michael C., Owen, Michael J., Holmans, Peter, Williams, Nigel, Craddock, Nicholas, Richards, Alexander, Humphreys, Isla, Meyer-Lindenberg, Andreas, Leweke, F. Markus, Tost, Heike, Akdeniz, Ceren, Rohleder, Cathrin, Bumb, J. Malte, Schwarz, Emanuel, Alptekin, Koksal, Ucok, Alp, Saka, Meram Can, Atbasoglu, E. Cem, Guloksuz, Sinan, Gumus-Akay, Guvem, Cihan, Burin, Karadag, Hasan, Soygur, Haldan, Cankurtaran, Eylem Sahin, Ulusoy, Semra, Akdede, Berna, Binbay, Tolga, Ayer, Ahmet, Noyan, Handan, Karadayi, Gulsah, Akturan, Elin, Ulas, Halis, Arango, Celso, Parellada, Mara, Bernardo, Miguel, Sanjuan, Julio, Bobes, Julio, Arrojo, Manuel, Luis Santos, Jose, Cuadrado, Pedro, Rodriguez Solano, Jose Juan, Carracedo, Angel, Garcia Bernardo, Enrique, Roldan, Laura, Lopez, Gonzalo, Cabrera, Bibiana, Cruz, Sabrina, Diaz Mesa, Eva Ma, Pouso, Maria, Jimenez, Estela, Sanchez, Teresa, Rapado, Marta, Gonzalez, Emiliano, Martinez, Covadonga, Sanchez, Emilio, Soledad Olmeda, Ma, de Haan, Lieuwe, Velthorst, Eva, van der Gaag, Mark, Selten, Jean-Paul, van Dam, Daniella, van der Ven, Elsje, van der Meer, Floor, Messchaert, Elles, Kraan, Tamar, Burger, Nadine, Leboyer, Marion, Szoke, Andrei, Schurhoff, Franck, Llorca, Pierre-Michel, Jamain, Stephane, Tortelli, Andrea, Frijda, Flora, Vilain, Jeanne, Galliot, Anne-Marie, Baudin, Gregoire, Ferchiou, Aziz, Richard, Jean-Romain, Bulzacka, Ewa, Charpeaud, Thomas, Tronche, Anne-Marie, De Hert, Marc, van Winkel, Ruud, Decoster, Jeroen, Derom, Catherine, Thiery, Evert, Stefanis, Nikos C., Sachs, Gabriele, Aschauer, Harald, Lasser, Iris, Winklbaur, Bernadette, Schlogelhofer, Monika, Riecher-Rossler, Anita, Borgwardt, Stefan, Walter, Anna, Harrisberger, Fabienne, Smieskova, Renata, Rapp, Charlotte, Ittig, Sarah, Soguel-Dit-Piquard, Fabienne, Studerus, Erich, Klosterkotter, Joachim, Ruhrmann, Stephan, Paruch, Julia, Julkowski, Dominika, Hilboll, Desiree, Sham, Pak C., Cherny, Stacey S., Chen, Eric Y. H., Campbell, Desmond D., Li, Miaoxin, Maria Romeo-Casabona, Carlos, Emaldi Cirion, Aitziber, Urruela Mora, Asier, Jones, Peter, Kirkbride, James, Cannon, Mary, Rujescu, Dan, Tarricone, Ilaria, Berardi, Domenico, Bonora, Elena, Seri, Marco, Marcacci, Thomas, Chiri, Luigi, Chierzi, Federico, Storbini, Viviana, Braca, Mauro, Minenna, Maria Gabriella, Donegani, Ivonne, Fioritti, Angelo, La Barbera, Daniele, La Cascia, Caterina Erika, Mule, Alice, Sideli, Lucia, Sartorio, Rachele, Ferraro, Laura, Tripoli, Giada, Seminerio, Fabio, Marinaro, Anna Maria, McGorry, Patrick, Nelson, Barnaby, Amminger, G. Paul, Pantelis, Christos, Menezes, Paulo R., Del-Ben, Cristina M., Tenan, Silvia H. Gallo, Shuhama, Rosana, Ruggeri, Mirella, Tosato, Sarah, Lasalvia, Antonio, Bonetto, Chiara, Ira, Elisa, Nordentoft, Merete, Krebs, Marie-Odile, Barrantes-Vidal, Neus, Cristobal, Paula, Kwapil, Thomas R., Brietzke, Elisa, Bressan, Rodrigo A., Gadelha, Ary, Maric, Nadja P., Andric, Sanja, Mihaljevic, Marina, Mirjanic, Tijana, van Os, Jim, Rutten, Bart P., Myin-Germeys, Inez, Delespaul, Philippe, Viechtbauer, Wolfgang, van Zelst, Catherine, Bruggeman, Richard, Reininghaus, Ulrich, Morgan, Craig, Murray, Robin M., Di Forti, Marta, McGuire, Philip, Valmaggia, Lucia R., Kempton, Matthew J., Gayer-Anderson, Charlotte, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Onyejiaka, Adanna, Bourque, Francois, Modinos, Gemma, Tognin, Stefania, Calem, Maria, O'Donovan, Michael C., Owen, Michael J., Holmans, Peter, Williams, Nigel, Craddock, Nicholas, Richards, Alexander, Humphreys, Isla, Meyer-Lindenberg, Andreas, Leweke, F. Markus, Tost, Heike, Akdeniz, Ceren, Rohleder, Cathrin, Bumb, J. Malte, Schwarz, Emanuel, Alptekin, Koksal, Ucok, Alp, Saka, Meram Can, Atbasoglu, E. Cem, Guloksuz, Sinan, Gumus-Akay, Guvem, Cihan, Burin, Karadag, Hasan, Soygur, Haldan, Cankurtaran, Eylem Sahin, Ulusoy, Semra, Akdede, Berna, Binbay, Tolga, Ayer, Ahmet, Noyan, Handan, Karadayi, Gulsah, Akturan, Elin, Ulas, Halis, Arango, Celso, Parellada, Mara, Bernardo, Miguel, Sanjuan, Julio, Bobes, Julio, Arrojo, Manuel, Luis Santos, Jose, Cuadrado, Pedro, Rodriguez Solano, Jose Juan, Carracedo, Angel, Garcia Bernardo, Enrique, Roldan, Laura, Lopez, Gonzalo, Cabrera, Bibiana, Cruz, Sabrina, Diaz Mesa, Eva Ma, Pouso, Maria, Jimenez, Estela, Sanchez, Teresa, Rapado, Marta, Gonzalez, Emiliano, Martinez, Covadonga, Sanchez, Emilio, Soledad Olmeda, Ma, de Haan, Lieuwe, Velthorst, Eva, van der Gaag, Mark, Selten, Jean-Paul, van Dam, Daniella, van der Ven, Elsje, van der Meer, Floor, Messchaert, Elles, Kraan, Tamar, Burger, Nadine, Leboyer, Marion, Szoke, Andrei, Schurhoff, Franck, Llorca, Pierre-Michel, Jamain, Stephane, Tortelli, Andrea, Frijda, Flora, Vilain, Jeanne, Galliot, Anne-Marie, Baudin, Gregoire, Ferchiou, Aziz, Richard, Jean-Romain, Bulzacka, Ewa, Charpeaud, Thomas, Tronche, Anne-Marie, De Hert, Marc, van Winkel, Ruud, Decoster, Jeroen, Derom, Catherine, Thiery, Evert, Stefanis, Nikos C., Sachs, Gabriele, Aschauer, Harald, Lasser, Iris, Winklbaur, Bernadette, Schlogelhofer, Monika, Riecher-Rossler, Anita, Borgwardt, Stefan, Walter, Anna, Harrisberger, Fabienne, Smieskova, Renata, Rapp, Charlotte, Ittig, Sarah, Soguel-Dit-Piquard, Fabienne, Studerus, Erich, Klosterkotter, Joachim, Ruhrmann, Stephan, Paruch, Julia, Julkowski, Dominika, Hilboll, Desiree, Sham, Pak C., Cherny, Stacey S., Chen, Eric Y. H., Campbell, Desmond D., Li, Miaoxin, Maria Romeo-Casabona, Carlos, Emaldi Cirion, Aitziber, Urruela Mora, Asier, Jones, Peter, Kirkbride, James, Cannon, Mary, Rujescu, Dan, Tarricone, Ilaria, Berardi, Domenico, Bonora, Elena, Seri, Marco, Marcacci, Thomas, Chiri, Luigi, Chierzi, Federico, Storbini, Viviana, Braca, Mauro, Minenna, Maria Gabriella, Donegani, Ivonne, Fioritti, Angelo, La Barbera, Daniele, La Cascia, Caterina Erika, Mule, Alice, Sideli, Lucia, Sartorio, Rachele, Ferraro, Laura, Tripoli, Giada, Seminerio, Fabio, Marinaro, Anna Maria, McGorry, Patrick, Nelson, Barnaby, Amminger, G. Paul, Pantelis, Christos, Menezes, Paulo R., Del-Ben, Cristina M., Tenan, Silvia H. Gallo, Shuhama, Rosana, Ruggeri, Mirella, Tosato, Sarah, Lasalvia, Antonio, Bonetto, Chiara, Ira, Elisa, Nordentoft, Merete, Krebs, Marie-Odile, Barrantes-Vidal, Neus, Cristobal, Paula, Kwapil, Thomas R., Brietzke, Elisa, Bressan, Rodrigo A., Gadelha, Ary, Maric, Nadja P., Andric, Sanja, Mihaljevic, Marina, and Mirjanic, Tijana more...
Abstract: Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G x E), however, so far, thorough replication of findings is rare and G x E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G x E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G x E in schizophrenia. While such investigations are now well underway, new challenges emerge for G x E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype. more...
Published: 2014

37. Identifying Gene-Environment Interactions in Schizophrenia:Contemporary Challenges for Integrated, Large-scale Investigations

Author: van Os, Jim, Rutten, Bart P, Myin-Germeys, Inez, Delespaul, Philippe, Viechtbauer, Wolfgang, van Zelst, Catherine, Bruggeman, Richard, Reininghaus, Ulrich, Morgan, Craig, Murray, Robin M, Di Forti, Marta, McGuire, Philip, Valmaggia, Lucia R, Kempton, Matthew J, Gayer-Anderson, Charlotte, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A, Onyejiaka, Adanna, Bourque, Francois, Modinos, Gemma, Tognin, Stefania, Calem, Maria, O'Donovan, Michael C, Owen, Michael J, Holmans, Peter, Williams, Nigel, Craddock, Nicholas, Richards, Alexander, Humphreys, Isla, Meyer-Lindenberg, Andreas, Leweke, F Markus, Tost, Heike, Akdeniz, Ceren, Rohleder, Cathrin, Bumb, J Malte, Schwarz, Emanuel, Alptekin, Köksal, Üçok, Alp, Saka, Meram Can, Atbaşoğlu, E Cem, Gülöksüz, Sinan, Gumus-Akay, Guvem, Cihan, Burçin, Karadağ, Hasan, Soygür, Haldan, Cankurtaran, Eylem Şahin, Ulusoy, Semra, Akdede, Berna, Nordentoft, Merete, van Os, Jim, Rutten, Bart P, Myin-Germeys, Inez, Delespaul, Philippe, Viechtbauer, Wolfgang, van Zelst, Catherine, Bruggeman, Richard, Reininghaus, Ulrich, Morgan, Craig, Murray, Robin M, Di Forti, Marta, McGuire, Philip, Valmaggia, Lucia R, Kempton, Matthew J, Gayer-Anderson, Charlotte, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A, Onyejiaka, Adanna, Bourque, Francois, Modinos, Gemma, Tognin, Stefania, Calem, Maria, O'Donovan, Michael C, Owen, Michael J, Holmans, Peter, Williams, Nigel, Craddock, Nicholas, Richards, Alexander, Humphreys, Isla, Meyer-Lindenberg, Andreas, Leweke, F Markus, Tost, Heike, Akdeniz, Ceren, Rohleder, Cathrin, Bumb, J Malte, Schwarz, Emanuel, Alptekin, Köksal, Üçok, Alp, Saka, Meram Can, Atbaşoğlu, E Cem, Gülöksüz, Sinan, Gumus-Akay, Guvem, Cihan, Burçin, Karadağ, Hasan, Soygür, Haldan, Cankurtaran, Eylem Şahin, Ulusoy, Semra, Akdede, Berna, and Nordentoft, Merete more...
Abstract: Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype. more...
Published: 2014

38. Poster #S7 META-ANALYSIS OF CHANGES IN BRAIN STRUCTURE IN HEALTHY INDIVIDUALS WITH A HISTORY OF CHILDHOOD ADVERSITY

Author: Calem, Maria, primary and Kempton, Matthew, additional
Published: 2014
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39. Increased Prevalence of Insomnia and Changes in Hypnotics Use in England over 15 Years: Analysis of the 1993, 2000, and 2007 National Psychiatric Morbidity Surveys

Author: Calem, Maria, primary, Bisla, Jatinder, additional, Begum, Aysha, additional, Dewey, Michael, additional, Bebbington, Paul E., additional, Brugha, Traolach, additional, Cooper, Claudia, additional, Jenkins, Rachel, additional, Lindesay, James, additional, McManus, Sally, additional, Meltzer, Howard, additional, Spiers, Nicola, additional, Weich, Scott, additional, and Stewart, Robert, additional more...
Published: 2012
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40. S42. NEUROANATOMY OF EMOTIONAL PROCESSING AND IMPACT ON CLINICAL OUTCOMES IN SUBJECTS AT HIGH RISK OF PSYCHOSIS.

Author: Modinos, Gemma, Kempton, Matthew, Tognin, Stefania, Calem, Maria, Porffy, Lilla, Antoniades, Mathilde, Azis, Matilda, Valmaggia, Lucia, and McGuire, Philip
Subjects: GRAY matter (Nerve tissue), EVALUATION of medical care, PSYCHOSES, FACE perception, CONFERENCES & conventions, NEUROANATOMY, EMOTION regulation
Abstract: Background The development of adverse clinical outcomes in psychosis has been associated with behavioral and neuroanatomical changes related to emotional processing (Aleman & Kahn, 2005; Philips & Seidman, 2008). However, the relationship between emotional processing deficits and neuroanatomy in subjects at clinical high risk of psychosis (CHR), and their relationship to longitudinal outcomes, remains unclear. The primary aim of the present study was to investigate the association between facial emotional recognition and grey matter volume (GMV) in a large cohort of CHR individuals compared to healthy controls, and their relationship with subsequent clinical outcomes. Methods Structural imaging scans at 3T and a computer-based measure of emotional processing (Degraded Facial Affect Recognition task, DFAR), were collected at baseline from 53 healthy controls (mean age: 23.3 SD ± 3.9; 52.8% male) and 213 CHR subjects (mean age: 22.9 SD ± 4.7; 50.7% male) participating in the multi-centre EU-GEI study (data pooled from 9 sites). CHR subjects were then clinically monitored for 12 months and clinical outcomes were assessed in terms of transition/non-transition to psychosis (CAARMS criteria) and the level of overall functioning (Global Assessment of Function scale; GAF). Structural images were preprocessed with voxel-based morphometry in SPM12. DFAR performance (total, happy, angry, fear and anger) was analyzed with repeated measures ANOVA at baseline (HC/CHR as between-group factor and DFAR as within-subject factor, adjusted for age, gender, IQ and site); and with binary logistic regression at the 12-month follow-up point (adjusting for the same variables). One-way ANOVAs in SPM12 were specified to examine interactions between group status (HC/CHR, CHR-T/CHR-NT, CHR-GO/CHR/PO) and DFAR performance (total, happy, angry, fear and anger), adjusting for the same variables. Statistical inferences were made at p<.05 after voxel-wise FWE correction within four pre-defined anatomical regions of interest (ROI: amygdala, hippocampus, insula, anterior cingulate cortex/medial prefrontal cortex -ACC/MPFC-). Results At baseline, DFAR performance did not differ between HC and CHR groups and was not significantly associated with GMV in our ROIs. At the 12-month follow-up point, 39 CHR subjects showed good overall functioning (GAF≥65), whereas 93 CHR subjects had a poor functional outcome (GAF score<65); 44 CHR subjects developed a psychotic disorder and 169 did not. Compared to subjects with a good functional outcome, CHR subjects with poor overall functioning showed exacerbated recognition of angry facial emotion (p=.030), decreased GMV in ACC and hippocampus (both p=.033 FWE), and a significantly different (inverse) association between angry facial emotion recognition and hippocampal volume compared to CHR subjects with good functioning (p=.037 FWE). CHR subjects who developed psychosis did not show significant differences in DFAR performance or significant associations between DFAR and GMV compared with CHR subjects who did not become psychotic. Discussion These findings indicate that adverse global functional outcomes in people at CHR of psychosis (but not transition to psychosis) are associated with baseline deficits in the recognition of angry facial emotion, which are in turn directly related to hippocampal volume decreases compared to CHR subjects with good functional outcomes. This has implications not only for stratification of CHR subjects according to baseline behavioral and volumetric characteristics, but also suggest potential preventative avenues for poorer outcomes focused on social cognitive and emotional processes. [ABSTRACT FROM AUTHOR] more...
Published: 2019
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41. Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis

Author: Pollak, Thomas A., Kempton, Matthew J., Iyegbe, Conrad, Vincent, Angela, Irani, Sarosh R., Coutinho, Ester, Menassa, David A., Jacobson, Leslie, de Haan, Lieuwe, Ruhrmann, Stephan, Sachs, Gabriele, Riecher-Roessler, Anita, Krebs, Marie-Odile, Amminger, Paul, Glenthoj, Birte, Barrantes-Vidal, Neus, van Os, Jim, Rutten, Bart P. F., Bressan, Rodrigo A., van der Gaag, Mark, Yolken, Robert, Hotopf, Matthew, Valmaggia, Lucia, Stone, James, David, Anthony S., McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Rosa, Araceli, Racioppi, Anna, Monsonet, Manel, Hinojosa-Marques, Lidia, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise, Nordentoft, Merete, Gebhard, Dominika, Arnhold, Julia, Klosterkoetter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., Pollak, Thomas A., Kempton, Matthew J., Iyegbe, Conrad, Vincent, Angela, Irani, Sarosh R., Coutinho, Ester, Menassa, David A., Jacobson, Leslie, de Haan, Lieuwe, Ruhrmann, Stephan, Sachs, Gabriele, Riecher-Roessler, Anita, Krebs, Marie-Odile, Amminger, Paul, Glenthoj, Birte, Barrantes-Vidal, Neus, van Os, Jim, Rutten, Bart P. F., Bressan, Rodrigo A., van der Gaag, Mark, Yolken, Robert, Hotopf, Matthew, Valmaggia, Lucia, Stone, James, David, Anthony S., McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Rosa, Araceli, Racioppi, Anna, Monsonet, Manel, Hinojosa-Marques, Lidia, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise, Nordentoft, Merete, Gebhard, Dominika, Arnhold, Julia, Klosterkoetter, Joachim, Lasser, Iris, Winklbaur, Bernadette, and Delespaul, Philippe A. more...
Abstract: Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic disorders. It is not known if they are present before the onset of psychosis or whether they are associated with particular clinical features or outcomes. In a case-control study, sera from 254 subjects at clinical high risk (CHR) for psychosis and 116 healthy volunteers were tested for antibodies against multiple neuronal antigens implicated in CNS autoimmune disorders, using fixed and live cell-based assays (CBAs). Within the CHR group, the relationship between NMDAR antibodies and symptoms, cognitive function and clinical outcomes over 24 month follow-up was examined. CHR subjects were not more frequently seropositive for neuronal autoantibodies than controls (8.3% vs. 5.2%; OR = 1.50; 95% CI: 0.58-3.90). The NMDAR was the most common target antigen and NMDAR IgGs were more sensitively detected with live versus fixed CBAs (p < 0.001). Preliminary phenotypic analyses revealed that within the CHR sample, the NMDAR antibody seropositive subjects had higher levels of current depression, performed worse on the Rey Auditory Verbal Learning Task (p < 0.05), and had a markedly lower IQ (p < 0.01). NMDAR IgGs were not more frequent in subjects who later became psychotic than those who did not. NMDAR antibody serostatus and titre was associated with poorer levels of functioning at follow-up (p < 0.05) and the presence of a neuronal autoantibody was associated with larger amygdala volumes (p < 0.05). Altogether, these findings demonstrate that NMDAR autoantibodies are detectable in a subgroup of CHR subjects at equal rates to controls. In the CHR group, they are associated with affective psychopathology, impairments in verbal memory, and overall cognitive function: these findings are qualitatively and individually similar to core features of autoimmune encephalitis and/or animal models of NMDAR antibody-mediated CNS disease. Overall the current more...

42. Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis

Author: Pollak, Thomas A., Kempton, Matthew J., Iyegbe, Conrad, Vincent, Angela, Irani, Sarosh R., Coutinho, Ester, Menassa, David A., Jacobson, Leslie, de Haan, Lieuwe, Ruhrmann, Stephan, Sachs, Gabriele, Riecher-Roessler, Anita, Krebs, Marie-Odile, Amminger, Paul, Glenthoj, Birte, Barrantes-Vidal, Neus, van Os, Jim, Rutten, Bart P. F., Bressan, Rodrigo A., van der Gaag, Mark, Yolken, Robert, Hotopf, Matthew, Valmaggia, Lucia, Stone, James, David, Anthony S., McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Rosa, Araceli, Racioppi, Anna, Monsonet, Manel, Hinojosa-Marques, Lidia, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise, Nordentoft, Merete, Gebhard, Dominika, Arnhold, Julia, Klosterkoetter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., Pollak, Thomas A., Kempton, Matthew J., Iyegbe, Conrad, Vincent, Angela, Irani, Sarosh R., Coutinho, Ester, Menassa, David A., Jacobson, Leslie, de Haan, Lieuwe, Ruhrmann, Stephan, Sachs, Gabriele, Riecher-Roessler, Anita, Krebs, Marie-Odile, Amminger, Paul, Glenthoj, Birte, Barrantes-Vidal, Neus, van Os, Jim, Rutten, Bart P. F., Bressan, Rodrigo A., van der Gaag, Mark, Yolken, Robert, Hotopf, Matthew, Valmaggia, Lucia, Stone, James, David, Anthony S., McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Rosa, Araceli, Racioppi, Anna, Monsonet, Manel, Hinojosa-Marques, Lidia, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise, Nordentoft, Merete, Gebhard, Dominika, Arnhold, Julia, Klosterkoetter, Joachim, Lasser, Iris, Winklbaur, Bernadette, and Delespaul, Philippe A. more...
Abstract: Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic disorders. It is not known if they are present before the onset of psychosis or whether they are associated with particular clinical features or outcomes. In a case-control study, sera from 254 subjects at clinical high risk (CHR) for psychosis and 116 healthy volunteers were tested for antibodies against multiple neuronal antigens implicated in CNS autoimmune disorders, using fixed and live cell-based assays (CBAs). Within the CHR group, the relationship between NMDAR antibodies and symptoms, cognitive function and clinical outcomes over 24 month follow-up was examined. CHR subjects were not more frequently seropositive for neuronal autoantibodies than controls (8.3% vs. 5.2%; OR = 1.50; 95% CI: 0.58-3.90). The NMDAR was the most common target antigen and NMDAR IgGs were more sensitively detected with live versus fixed CBAs (p < 0.001). Preliminary phenotypic analyses revealed that within the CHR sample, the NMDAR antibody seropositive subjects had higher levels of current depression, performed worse on the Rey Auditory Verbal Learning Task (p < 0.05), and had a markedly lower IQ (p < 0.01). NMDAR IgGs were not more frequent in subjects who later became psychotic than those who did not. NMDAR antibody serostatus and titre was associated with poorer levels of functioning at follow-up (p < 0.05) and the presence of a neuronal autoantibody was associated with larger amygdala volumes (p < 0.05). Altogether, these findings demonstrate that NMDAR autoantibodies are detectable in a subgroup of CHR subjects at equal rates to controls. In the CHR group, they are associated with affective psychopathology, impairments in verbal memory, and overall cognitive function: these findings are qualitatively and individually similar to core features of autoimmune encephalitis and/or animal models of NMDAR antibody-mediated CNS disease. Overall the current more...

43. Association of Adverse Outcomes With Emotion Processing and Its Neural Substrate in Individuals at Clinical High Risk for Psychosis.

Author: Modinos G, Kempton MJ, Tognin S, Calem M, Porffy L, Antoniades M, Mason A, Azis M, Allen P, Nelson B, McGorry P, Pantelis C, Riecher-Rössler A, Borgwardt S, Bressan R, Barrantes-Vidal N, Krebs MO, Nordentoft M, Glenthøj B, Ruhrmann S, Sachs G, Rutten B, van Os J, de Haan L, Velthorst E, van der Gaag M, Valmaggia LR, and McGuire P more...
Subjects: Brain diagnostic imaging, Case-Control Studies, Emotions, Facial Recognition, Female, Gray Matter diagnostic imaging, Gray Matter pathology, Gray Matter physiopathology, Humans, Magnetic Resonance Imaging, Male, Neuroimaging, Psychiatric Status Rating Scales, Psychotic Disorders diagnostic imaging, Psychotic Disorders pathology, Young Adult, Brain pathology, Emotional Intelligence, Psychotic Disorders psychology
Abstract: Importance: The development of adverse clinical outcomes in patients with psychosis has been associated with behavioral and neuroanatomical deficits related to emotion processing. However, the association between alterations in brain regions subserving emotion processing and clinical outcomes remains unclear., Objective: To examine the association between alterations in emotion processing and regional gray matter volumes in individuals at clinical high risk (CHR) for psychosis, and the association with subsequent clinical outcomes., Design, Setting, and Participants: This naturalistic case-control study with clinical follow-up at 12 months was conducted from July 1, 2010, to August 31, 2016, and collected data from 9 psychosis early detection centers (Amsterdam, Basel, Cologne, Copenhagen, London, Melbourne, Paris, The Hague, and Vienna). Participants (213 individuals at CHR and 52 healthy controls) were enrolled in the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) project. Data were analyzed from October 1, 2018, to April 24, 2019., Main Measures and Outcomes: Emotion recognition was assessed with the Degraded Facial Affect Recognition Task. Three-Tesla magnetic resonance imaging scans were acquired from all participants, and gray matter volume was measured in regions of interest (medial prefrontal cortex, amygdala, hippocampus, and insula). Clinical outcomes at 12 months were evaluated for transition to psychosis using the Comprehensive Assessment of At-Risk Mental States criteria, and the level of overall functioning was measured through the Global Assessment of Functioning [GAF] scale., Results: A total of 213 individuals at CHR (105 women [49.3%]; mean [SD] age, 22.9 [4.7] years) and 52 healthy controls (25 women [48.1%]; mean [SD] age, 23.3 [4.0] years) were included in the study at baseline. At the follow-up within 2 years of baseline, 44 individuals at CHR (20.7%) had developed psychosis and 169 (79.3%) had not. Of the individuals at CHR reinterviewed with the GAF, 39 (30.0%) showed good overall functioning (GAF score, ≥65), whereas 91 (70.0%) had poor overall functioning (GAF score, <65). Within the CHR sample, better anger recognition at baseline was associated with worse functional outcome (odds ratio [OR], 0.88; 95% CI, 0.78-0.99; P = .03). In individuals at CHR with a good functional outcome, positive associations were found between anger recognition and hippocampal volume (ze = 3.91; familywise error [FWE] P = .02) and between fear recognition and medial prefrontal cortex volume (z = 3.60; FWE P = .02), compared with participants with a poor outcome. The onset of psychosis was not associated with baseline emotion recognition performance (neutral OR, 0.93; 95% CI, 0.79-1.09; P = .37; happy OR, 1.03; 95% CI, 0.84-1.25; P = .81; fear OR, 0.98; 95% CI, 0.85-1.13; P = .77; anger OR, 1.00; 95% CI, 0.89-1.12; P = .96). No difference was observed in the association between performance and regional gray matter volumes in individuals at CHR who developed or did not develop psychosis (FWE P < .05)., Conclusions and Relevance: In this study, poor functional outcome in individuals at CHR was found to be associated with baseline abnormalities in recognizing negative emotion. This finding has potential implications for the stratification of individuals at CHR and suggests that interventions that target socioemotional processing may improve functional outcomes. more...
Published: 2020
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44. Increased Resting Hippocampal and Basal Ganglia Perfusion in People at Ultra High Risk for Psychosis: Replication in a Second Cohort.

Author: Allen P, Azis M, Modinos G, Bossong MG, Bonoldi I, Samson C, Quinn B, Kempton MJ, Howes OD, Stone JM, Calem M, Perez J, Bhattacharayya S, Broome MR, Grace AA, Zelaya F, and McGuire P
Subjects: Adult, Basal Ganglia diagnostic imaging, Case-Control Studies, Female, Hippocampus diagnostic imaging, Humans, Magnetic Resonance Imaging, Male, Psychotic Disorders diagnostic imaging, Rest, Risk, Young Adult, Adult Survivors of Child Adverse Events, Basal Ganglia physiopathology, Cerebrovascular Circulation physiology, Hippocampus physiopathology, Neuroimaging methods, Psychotic Disorders physiopathology
Abstract: We recently reported that resting hippocampal, basal ganglia and midbrain perfusion is elevated in people at ultra high risk (UHR) for psychosis. The present study sought to replicate our previous finding in an independent UHR cohort, and examined the relationship between resting perfusion in these regions, psychosis and depression symptoms, and traumatic experiences in childhood. Pseudo-Continuous Arterial Spin Labelling (p-CASL) imaging was used to measure resting cerebral blood flow (rCBF) in 77 UHR for psychosis individuals and 25 healthy volunteers in a case-control design. UHR participants were recruited from clinical early detection services at 3 sites in the South of England. Symptoms levels were assessed using the Comprehensive Assessment of At Risk Mental States (CAARMS), the Hamilton Depression Scale (HAM-D), and childhood trauma was assessed retrospectively using the Childhood Trauma Questionnaire (CTQ). Right hippocampal and basal ganglia rCBF were significantly increased in UHR subjects compared to controls, partially replicating our previous finding in an independent cohort. In UHR participants, positive symptoms were positively correlated with rCBF in the right pallidum. CTQ scores were positively correlated with rCBF values in the bilateral hippocampus and negatively associated with rCBF in the left prefrontal cortex. Elevated resting hippocampal and basal ganglia activity appears to be a consistent finding in individuals at high risk for psychosis, consistent with data from preclinical models of the disorder. The association with childhood trauma suggests that its influence on the risk of psychosis may be mediated through an effect on hippocampal function. more...
Published: 2018
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45. Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations.

Author: van Os J, Rutten BP, Myin-Germeys I, Delespaul P, Viechtbauer W, van Zelst C, Bruggeman R, Reininghaus U, Morgan C, Murray RM, Di Forti M, McGuire P, Valmaggia LR, Kempton MJ, Gayer-Anderson C, Hubbard K, Beards S, Stilo SA, Onyejiaka A, Bourque F, Modinos G, Tognin S, Calem M, O'Donovan MC, Owen MJ, Holmans P, Williams N, Craddock N, Richards A, Humphreys I, Meyer-Lindenberg A, Leweke FM, Tost H, Akdeniz C, Rohleder C, Bumb JM, Schwarz E, Alptekin K, Üçok A, Saka MC, Atbaşoğlu EC, Gülöksüz S, Gumus-Akay G, Cihan B, Karadağ H, Soygür H, Cankurtaran EŞ, Ulusoy S, Akdede B, Binbay T, Ayer A, Noyan H, Karadayı G, Akturan E, Ulaş H, Arango C, Parellada M, Bernardo M, Sanjuán J, Bobes J, Arrojo M, Santos JL, Cuadrado P, Rodríguez Solano JJ, Carracedo A, García Bernardo E, Roldán L, López G, Cabrera B, Cruz S, Díaz Mesa EM, Pouso M, Jiménez E, Sánchez T, Rapado M, González E, Martínez C, Sánchez E, Olmeda MS, de Haan L, Velthorst E, van der Gaag M, Selten JP, van Dam D, van der Ven E, van der Meer F, Messchaert E, Kraan T, Burger N, Leboyer M, Szoke A, Schürhoff F, Llorca PM, Jamain S, Tortelli A, Frijda F, Vilain J, Galliot AM, Baudin G, Ferchiou A, Richard JR, Bulzacka E, Charpeaud T, Tronche AM, De Hert M, van Winkel R, Decoster J, Derom C, Thiery E, Stefanis NC, Sachs G, Aschauer H, Lasser I, Winklbaur B, Schlögelhofer M, Riecher-Rössler A, Borgwardt S, Walter A, Harrisberger F, Smieskova R, Rapp C, Ittig S, Soguel-dit-Piquard F, Studerus E, Klosterkötter J, Ruhrmann S, Paruch J, Julkowski D, Hilboll D, Sham PC, Cherny SS, Chen EY, Campbell DD, Li M, Romeo-Casabona CM, Emaldi Cirión A, Urruela Mora A, Jones P, Kirkbride J, Cannon M, Rujescu D, Tarricone I, Berardi D, Bonora E, Seri M, Marcacci T, Chiri L, Chierzi F, Storbini V, Braca M, Minenna MG, Donegani I, Fioritti A, La Barbera D, La Cascia CE, Mulè A, Sideli L, Sartorio R, Ferraro L, Tripoli G, Seminerio F, Marinaro AM, McGorry P, Nelson B, Amminger GP, Pantelis C, Menezes PR, Del-Ben CM, Gallo Tenan SH, Shuhama R, Ruggeri M, Tosato S, Lasalvia A, Bonetto C, Ira E, Nordentoft M, Krebs MO, Barrantes-Vidal N, Cristóbal P, Kwapil TR, Brietzke E, Bressan RA, Gadelha A, Maric NP, Andric S, Mihaljevic M, and Mirjanic T more...
Subjects: Genetic Predisposition to Disease, Humans, Schizophrenia epidemiology, Social Environment, Gene-Environment Interaction, Schizophrenia genetics, Schizophrenic Psychology
Abstract: Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype., (© The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.) more...
Published: 2014
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