1. Plant-based Sterols and Stanols in Health & Disease: 'Consequences of Human Development in a Plant-Based Environment?'
- Author
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Plat, J, Baumgartner, S, Vanmierlo, T, Lütjohann, D, Calkins, K L, Burrin, D G, Guthrie, G, Thijs, C, Te Velde, A A, Vreugdenhil, A C E, Sverdlov, R, Garssen, J, Wouters, K, Trautwein, E A, Wolfs, T G, van Gorp, C, Mulder, M T, Riksen, N P, Groen, A K, Mensink, R P, Afd Pharmacology, Pharmacology, Afd Pharmacology, Pharmacology, and Internal Medicine
- Subjects
0106 biological sciences ,0301 basic medicine ,Plant stanols ,RECEPTOR-DEFICIENT MICE ,Sitosterols/administration & dosage ,Physiology ,Disease ,01 natural sciences ,Biochemistry ,Inflammatory bowel disease ,chemistry.chemical_compound ,Cholesterol/metabolism ,Non-alcoholic Fatty Liver Disease ,Phytosterols/administration & dosage ,INFANT FORMULAS ,Non-alcoholic steatohepatitis ,FISH-OIL ,DIETARY-CHOLESTEROL ,beta-Sitosterol ,Phytosterols ,Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16] ,BETA-SITOSTEROL ,Intestinal Absorption/drug effects ,Cardiovascular disease ,3. Good health ,INTESTINAL CHOLESTEROL ABSORPTION ,Cholesterol ,Cardiovascular Diseases ,FAT DIET ,Intestinal cholesterol absorption ,LIPID EMULSIONS ,lipids (amino acids, peptides, and proteins) ,LDL/antagonists & inhibitors ,Cholesterol, LDL/antagonists & inhibitors ,Intestinal-failure associated liver disease ,Immune fitness ,Breast milk ,Plant sterols ,LDL RECEPTOR ,03 medical and health sciences ,Cholesterol precursors ,SDG 3 - Good Health and Well-being ,LIVER-DISEASE ,Inflammatory Bowel Diseases/drug therapy ,medicine ,Humans ,Asthma/drug therapy ,business.industry ,Cell Biology ,Cholesterol, LDL ,medicine.disease ,Inflammatory Bowel Diseases ,Sitosterols ,Asthma ,030104 developmental biology ,Parenteral nutrition ,chemistry ,Intestinal Absorption ,Non-alcoholic Fatty Liver Disease/drug therapy ,Oxyphytosterols ,Steatohepatitis ,Cardiovascular Diseases/drug therapy ,business ,010606 plant biology & botany - Abstract
Contains fulltext : 206793.pdf (Publisher’s version ) (Open Access) Dietary plant sterols and stanols as present in our diet and in functional foods are well-known for their inhibitory effects on intestinal cholesterol absorption, which translates into lower low-density lipoprotein cholesterol concentrations. However, emerging evidence suggests that plant sterols and stanols have numerous additional health effects, which are largely unnoticed in the current scientific literature. Therefore, in this review we pose the intriguing question "What would have occurred if plant sterols and stanols had been discovered and embraced by disciplines such as immunology, hepatology, pulmonology or gastroenterology before being positioned as cholesterol-lowering molecules?" What would then have been the main benefits and fields of application of plant sterols and stanols today? We here discuss potential effects ranging from its presence and function intrauterine and in breast milk towards a potential role in the development of non-alcoholic steatohepatitis (NASH), cardiovascular disease (CVD), inflammatory bowel diseases (IBD) and allergic asthma. Interestingly, effects clearly depend on the route of entrance as observed in intestinal-failure associated liver disease (IFALD) during parenteral nutrition regimens. It is only until recently that effects beyond lowering of cholesterol concentrations are being explored systematically. Thus, there is a clear need to understand the full health effects of plant sterols and stanols.
- Published
- 2019
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