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427 results on '"Callicott, Joseph H."'

1. KCNH2-3.1 mediates aberrant complement activation and impaired hippocampal-medial prefrontal circuitry associated with working memory deficits

Author

Ren, Ming, Hu, Zhonghua, Chen, Qiang, Jaffe, Andrew, Li, Yingbo, Sadashivaiah, Vijay, Zhu, Shujuan, Rajpurohit, Nina, Heon Shin, Joo, Xia, Wei, Jia, Yankai, Wu, Jingxian, Lang Qin, Sunny, Li, Xinjian, Zhu, Jian, Tian, Qingjun, Paredes, Daniel, Zhang, Fengyu, Wang, Kuan Hong, Mattay, Venkata S., Callicott, Joseph H., Berman, Karen F., Weinberger, Daniel R., and Yang, Feng

Published
2020
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4. Variation in GRM3 Affects Cognition, Prefrontal Glutamate, and Risk for Schizophrenia

Author

Egan, Michael F., Straub, Richard E., Goldberg, Terry E., Yakub, Imtiaz, Callicott, Joseph H., Hariri, Ahmad R., Mattay, Venkata S., Bertolino, Alessandro, Hyde, Thomas M., Shannon-Weickert, Cynthia, Akil, Mayada, Crook, Jeremy, Vakkalanka, Radha Krishna, Balkissoon, Rishi, Gibbs, Richard A., Kleinman, Joel E., Weinberger, Daniel R., and Mishkin, Mortimer

Published
2004

10. The Evolutionarily Conserved G Protein-Coupled Receptor SREB2/GPR85 Influences Brain Size, Behavior, and Vulnerability to Schizophrenia

Author

Matsumoto, Mitsuyuki, Straub, Richard E., Marenco, Stefano, Nicodemus, Kristin K., Matsumoto, Shun-ichiro, Fujikawa, Akihiko, Miyoshi, Sosuke, Shobo, Miwako, Takahashi, Shinji, Yarimizu, Junko, Yuri, Masatoshi, Hiramoto, Masashi, Morita, Shuji, Yokota, Hiroyuki, Sasayama, Takeshi, Terai, Kazuhiro, Yoshino, Masayasu, Miyake, Akira, Callicott, Joseph H., Egan, Michael F., Meyer-Lindenberg, Andreas, Kempf, Lucas, Honea, Robyn, Vakkalanka, Radha Krishna, Takasaki, Jun, Kamohara, Masazumi, Soga, Takatoshi, Hiyama, Hideki, Ishii, Hiroyuki, Matsuo, Ayako, Nishimura, Shintaro, Matsuoka, Nobuya, Kobori, Masato, Matsushime, Hitoshi, Katoh, Masao, Furuichi, Kiyoshi, and Weinberger, Daniel R.

Published
2008
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15. DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity

Author

Callicott, Joseph H., Feighery, Emer L., Mattay, Venkata S., White, Michael G., Chen, Qiang, Baranger, David A.A., Berman, Karen F., Lu, Bai, Song, Hongjun, Ming, Guo-li, and Weinberger, Daniel R.

Subjects
Schizophrenia -- Genetic aspects, Neurochemistry -- Research, Parahippocampal region -- Physiological aspects -- Genetic aspects, GABA -- Physiological aspects, Developmental neurophysiology -- Research, Health care industry
Abstract

Hippocampal development is coordinated by both extracellular factors like GABA neurotransmission and intracellular components like DISC1. We previously reported that SLC12A2-dependent GABA depolarization and DISC1 coregulate hippocampal neuronal development, and [...]

Published
2013
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19. Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls

Author

Nicodemus, Kristin K., Law, Amanda J., Radulescu, Eugenia, Luna, Augustin, Kolachana, Bhaskar, Vakkalanka, Radhakrishna, Rujescu, Dan, Giegling, Ina, Straub, Richard E., McGee, Kate, Gold, Bert, Dean, Michael, Muglia, Pierandrea, Callicott, Joseph H., Tan, Hao-Yang, and Weinberger, Daniel R.

Subjects
Schizophrenia -- Risk factors, Schizophrenia -- Genetic aspects, Schizophrenia -- Research, Genetic epistasis -- Research, Neuroimaging -- Usage, Neuroimaging -- Research, Health, Psychology and mental health
Published
2010

20. Genetic variation in CACNA1C affects brain circuitries related to mental illness

Author

Bigos, Kristin L., Mattay, Venkata S., Callicott, Joseph H., Straub, Richard E., Vakkalanka, Radhakrishna, Kolachana, Bhaskar, Hyde, Thomas M., Lipska, Barbara K., Kleinman, Joel E., and Weinberger, Daniel R.

Subjects
Mental illness -- Research, Mental illness -- Genetic aspects, Gene expression -- Research, Gene expression -- Physiological aspects, Brain research -- Physiological aspects, Genetic polymorphisms -- Research, Health, Psychology and mental health
Published
2010

21. Differential Effects of Common Variants in SCN2A on General Cognitive Ability, Brain Physiology, and messenger RNA Expression in Schizophrenia Cases and Control Individuals

Author

Dickinson, Dwight, Straub, Richard E., Trampush, Joey W., Gao, Yuan, Feng, Ningping, Xie, Bin, Shin, Joo Heon, Lim, Hun Ki, Ursini, Gianluca, Bigos, Kristin L., Kolachana, Bhaskar, Hashimoto, Ryota, Takeda, Masatoshi, Baum, Graham L., Rujescu, Dan, Callicott, Joseph H., Hyde, Thomas M., Berman, Karen F., Kleinman, Joel E., and Weinberger, Daniel R.

Published
2014
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23. Age-related alterations in simple declarative memory and the effect of negative stimulus valence

Author

Murty, Vishnu P., Sambataro, Fabio, Das, Saumitra, Tan, Hao-Yang, Callicott, Joseph H., Goldberg, Terry E., Meyer- Lindenberg, Andreas, Weinberger, Daniel R., and Mattay, Venkata S.

Subjects
Magnetic resonance imaging -- Usage, Magnetic resonance imaging -- Health aspects, Aging -- Physiological aspects, Aging -- Research, Amygdala (Brain) -- Physiological aspects, Amygdala (Brain) -- Research, Health, Psychology and mental health
Published
2009

24. A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia

Author

Huffaker, Stephen J., Chen, Jingshan, Nicodemus, Kristin K., Sambataro, Fabio, Yang, Feng, Mattay, Venkata, Lipska, Barbara K., Hyde, Thomas M., Song, Jian, Rujescu, Dan, Giegling, Ina, Mayilyan, Karine, Proust, Morgan J., Soghoyan, Armen, Caforio, Grazia, Callicott, Joseph H., Bertolino, Alessandro, Meyer-Lindenberg, Andreas, Chang, Jay, Ji, Yuanyuan, Egan, Michael F., Goldberg, Terry E., Kleinman, Joel E., Lu, Bai, and Weinberger, Daniel R.

Subjects
Genetic susceptibility -- Research, Potassium channels -- Physiological aspects, Potassium channels -- Genetic aspects, Potassium channels -- Research, Schizophrenia -- Risk factors, Schizophrenia -- Drug therapy, Schizophrenia -- Genetic aspects, Schizophrenia -- Research, Single nucleotide polymorphisms -- Research
Abstract

Organized neuronal firing is crucial for cortical processing and is disrupted in schizophrenia. Using rapid amplification of 5' complementary DNA ends in human brain, we identified a primate-specific isoform (3.1) of the ether-a-go-go-related [K.sup.+] channel KCNH2 that modulates neuronal firing. KCNH2-3.1 messenger RNA levels are comparable to full-length KCNH2 (lA) levels in brain but three orders of magnitude lower in heart. In hippocampus from individuals with schizophrenia, KCNH2-3.1 expression is 2.5-fold greater than KCNH2-lA expression. A meta-analysis of five clinical data sets (367 families, 1,158 unrelated cases and 1,704 controls) shows association of single nucleotide polymorphisms in KCNH2 with schizophrenia. Risk-associated alleles predict lower intelligence quotient scores and speed of cognitive processing, altered memory-linked functional magnetic resonance imaging signals and increased KCNH2-3.1 mRNA levels in postmortem hippocampus. KCNH2-3.1 lacks a domain that is crucial for slow channel deactivation. Overexpression of KCNH2-3.1 in primary cortical neurons induces a rapidly deactivating [K.sup.+] current and a high-frequency, nonadapting firing pattern. These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target., A major challenge in modern medicine is to understand cellular and molecular mechanisms underlying common mental illnesses such as schizophrenia, which involve complicated genetic and environmental determinantsl. Prevailing etiological hypotheses [...]

Published
2009

25. Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans

Author

Tan, Hao-Yang, Nicodemus, Kristin K., Chen, Qiang, Li, Zhen, Brooke, Jennifer K., Honea, Robyn, Kolachana, Bhaskar S., Straub, Richard E., Meyer-Lindenberg, Andreas, Sei, Yoshitasu, Mattay, Venkata S., Callicott, Joseph H., and Weinberger, Daniel R.

Subjects
Genetic variation -- Health aspects, Prefrontal cortex -- Structure, Prefrontal cortex -- Physiological aspects, Protein kinases -- Physiological aspects, Protein kinases -- Genetic aspects, Protein kinases -- Research
Abstract

AKT1-dependent molecular pathways control diverse aspects of cellular development and adaptation, including interactions with neuronal dopaminergic signaling. If AKT1 has an impact on dopaminergic signaling, then genetic variation in AKT1 would be associated with brain phenotypes related to cortical dopaminergic function. Here, we provide evidence that a coding variation in AKT1 that affects protein expression in human B lymphoblasts influenced several brain measures related to dopaminergic function. Cognitive performance linked to frontostriatal circuitry, prefrontal physiology during executive function, and frontostriatal gray-matter volume on MRI were altered in subjects with the AKT1 variation. Moreover, on neuroimaging measures with a main effect of the AKT1 genotype, there was significant epistasis with a functional polymorphism (Val158Met) in catechol-O-methyltransferase [COMT], a gene that indexes cortical synaptic dopamine. This genetic interaction was consistent with the putative role of AKT1 in dopaminergic signaling. Supportive of an earlier tentative association of AKT1 with schizophrenia, we also found that this AKT1 variant was associated with risk for schizophrenia. These data implicate AKT1 in modulating human prefrontal-striatal structure and function and suggest that the mechanism of this effect may be coupled to dopaminergic signaling and relevant to the expression of psychosis., Introduction Dopaminergic abnormalities have long served as a major frame-work for understanding the pathophysiology as well as pharmacology of psychosis, such as schizophrenia, and also associated cognitive deficits, particularly those [...]

Published
2008

26. Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition

Author

Meyer-Lindenberg, Andreas, Straub, Richard E., Lipska, Barbara K., Verchinski, Beth A., Goldberg, Terry, Callicott, Joseph H., Egan, Michael F., Huffaker, Stephen S., Mattay, Venkata S., Kolachana, Bhaskar, Kleinman, Joel E., and Weinberger, Daniel R.

Subjects
Molecular weights -- Case studies, Neurons -- Genetic aspects, Neurons -- Case studies, Cardiac glycosides, Cardiotonic agents, Cognition, Dopamine, Phosphoproteins
Abstract

Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32), encoded by PPP1R1B, is a pivotal integrator of information in dopaminoceptive neurons, regulating the response to neuroleptics, psychotomimetics, and drugs [...]

Published
2007

31. KCNH2-3.1 mediates aberrant complement activation and impaired hippocampal-medial prefrontal circuitry associated with working memory deficits

Author

Ren, Ming, primary, Hu, Zhonghua, additional, Chen, Qiang, additional, Jaffe, Andrew, additional, Li, Yingbo, additional, Sadashivaiah, Vijay, additional, Zhu, Shujuan, additional, Rajpurohit, Nina, additional, Heon Shin, Joo, additional, Xia, Wei, additional, Jia, Yankai, additional, Wu, Jingxian, additional, Lang Qin, Sunny, additional, Li, Xinjian, additional, Zhu, Jian, additional, Tian, Qingjun, additional, Paredes, Daniel, additional, Zhang, Fengyu, additional, Wang, Kuan Hong, additional, Mattay, Venkata S., additional, Callicott, Joseph H., additional, Berman, Karen F., additional, Weinberger, Daniel R., additional, and Yang, Feng, additional

Published
2019
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36. Enuresis as a premorbid developmental marker of schizophrenia*

Author

Hyde, Thomas M., Deep-Soboslay, Amy, Iglesias, Bianca, Callicott, Joseph H., Gold, James M., Meyer-Lindenberg, Andreas, Honea, Robyn A., Bigelow, Llewellyn B., Egan, Michael F., Emsellem, Esther M., and Weinberger, Daniel R.

Published
2008

37. A Voxelwise and Genome-Wide Association Study

Author

Luo, Qiang, Chen, Qiang, Wang, Wenjia, Desrivières, Sylvane, Quinlan, Erin Burke, Jia, Tianye, Macare, Christine, Robert, Gabriel H., Cui, Jing, Guedj, Mickaël, Palaniyappan, Lena, Kherif, Ferath, Banaschewski, Tobias, Bokde, Arun L. W., Büchel, Christian, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Artiges, Eric, Paillère-Martinot, Marie-Laure, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Poustka, Luise, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Callicott, Joseph H., Mattay, Venkata S., Pausova, Zdenka, Dartigues, Jean-François, Tzourio, Christophe, Crivello, Fabrice, Berman, Karen F., Li, Fei, Paus, Tomáš, Weinberger, Daniel R., Murray, Robin M., Schumann, Gunter, and Feng, Jianfeng

Subjects
Adult, Male, Adolescent, Research, Siblings, Mutation, Missense, Putamen, Schizophrenia, Neuroimaging, Hypertrophy, Magnetic Resonance Imaging, Case-Control Studies, mental disorders, RC0321, Online First, Humans, Female, Genetic Predisposition to Disease, Gray Matter, Cation Transport Proteins, Original Investigation, Genome-Wide Association Study
Abstract

Key Points Question Is there any genetic variant associated with adolescent brain development that can inform psychopathology of schizophrenia? Findings In this imaging genetics study of brain structure, a significant association between a missense mutation in SLC39A8 (a gene previously associated with schizophrenia) and gray matter volume in putamen was discovered and replicated using 10 411 healthy participants from 5 independent studies. Compared with healthy control individuals, such association was significantly weakened in both patients with schizophrenia and unaffected siblings. Meaning Common genetic variant indicates an involvement of neuronal ion transport in both pathophysiology of schizophrenia and structural development of putamen., Importance Deviation from normal adolescent brain development precedes manifestations of many major psychiatric symptoms. Such altered developmental trajectories in adolescents may be linked to genetic risk for psychopathology. Objective To identify genetic variants associated with adolescent brain structure and explore psychopathologic relevance of such associations. Design, Setting, and Participants Voxelwise genome-wide association study in a cohort of healthy adolescents aged 14 years and validation of the findings using 4 independent samples across the life span with allele-specific expression analysis of top hits. Group comparison of the identified gene-brain association among patients with schizophrenia, unaffected siblings, and healthy control individuals. This was a population-based, multicenter study combined with a clinical sample that included participants from the IMAGEN cohort, Saguenay Youth Study, Three-City Study, and Lieber Institute for Brain Development sample cohorts and UK biobank who were assessed for both brain imaging and genetic sequencing. Clinical samples included patients with schizophrenia and unaffected siblings of patients from the Lieber Institute for Brain Development study. Data were analyzed between October 2015 and April 2018. Main Outcomes and Measures Gray matter volume was assessed by neuroimaging and genetic variants were genotyped by Illumina BeadChip. Results The discovery sample included 1721 adolescents (873 girls [50.7%]), with a mean (SD) age of 14.44 (0.41) years. The replication samples consisted of 8690 healthy adults (4497 women [51.8%]) from 4 independent studies across the life span. A nonsynonymous genetic variant (minor T allele of rs13107325 in SLC39A8, a gene implicated in schizophrenia) was associated with greater gray matter volume of the putamen (variance explained of 4.21% in the left hemisphere; 8.66; 95% CI, 6.59-10.81; P = 5.35 × 10−18; and 4.44% in the right hemisphere; t = 8.90; 95% CI, 6.75-11.19; P = 6.80 × 10−19) and also with a lower gene expression of SLC39A8 specifically in the putamen (t127 = −3.87; P = 1.70 × 10−4). The identified association was validated in samples across the life span but was significantly weakened in both patients with schizophrenia (z = −3.05; P = .002; n = 157) and unaffected siblings (z = −2.08; P = .04; n = 149). Conclusions and Relevance Our results show that a missense mutation in gene SLC39A8 is associated with larger gray matter volume in the putamen and that this association is significantly weakened in schizophrenia. These results may suggest a role for aberrant ion transport in the etiology of psychosis and provide a target for preemptive developmental interventions aimed at restoring the functional effect of this mutation., This imaging genetics study examines genetic variants associated with adolescent brain structure and explores the psychopathologic relevance of such associations in the development of schizophrenia.

Published
2019

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