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1. Evidence of Zika Virus Reinfection by Genome Diversity and Antibody Response Analysis, Brazil

Author

Castilho, Marcia da Costa, de Filippis, Ana Maria Bispo, Machado, Lais Ceschini, de Lima Calvanti, Thaise Yasmine Vasconcelos, Lima, Morganna Costa, Fonseca, Vagner, Giovanetti, Marta, Docena, Cassia, Neto, Armando Menezes, Botto-Menezes, Camila Helena Aguiar, Kara, Edna Oliveira, de La Barrera, Rafael, Modjarrad, Kayvon, Giozza, Silvana Pereira, Pereira, Gerson Fernando, Alcantara, Luiz Carlos Junior, Broutet, Nathalie Jeanne Nicole, Calvet, Guilherme Amaral, Wallau, Gabriel Luz, and Franca, Rafael Freitas Oliveira

Subjects
Diagnosis, Genetic aspects, Recurrence (Disease) -- Genetic aspects -- Diagnosis, Zika virus infection -- Genetic aspects -- Diagnosis, Diseases -- Relapse
Abstract

Zika virus (ZIKV) is an arthropodborne virus belonging to the Flaviviridae family. Virions are enveloped for a single-stranded positive-sense RNA genome of [approximately equal to]10.8-kb (1). ZIKV is transmitted through [...]

Published
2024
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2. Cohort-profile: Household transmission of SARS-CoV-2 in a low-resource community in Rio de Janeiro, Brazil

Author

Brasil, Patrícia, Damasceno, Luana, Fuller, Trevon, Bastos, Leonardo S, Cruz, Oswaldo G, Medeiros, Fernando, Calvet, Guilherme Amaral, Resende, Paola, Whitworth, Jimmy, Smith, Chris, Siqueira, Marilda M, and Carvalho, Marilia

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Prevention, Clinical Research, Infectious Diseases, Emerging Infectious Diseases, Biodefense, Immunization, Vaccine Related, Biotechnology, Lung, Infection, Good Health and Well Being, Adult, Child, Humans, Female, Male, SARS-CoV-2, COVID-19, Prospective Studies, Pandemics, Brazil, Antibodies, Community child health, Epidemiology, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

PurposeTo better understand the household transmission of SARS-COV-2 in a low-resource community in Rio de Janeiro during the COVID-19 pandemic (2020-2022).ParticipantsThis is an open prospective cohort study of children ≤12 years old and their household contacts. During home visits over 24 months, we collected data on sociodemographic characteristics, behavioural data, clinical manifestations of SARS-CoV-2, vaccination status, SARS-CoV-2 (reverse transcription-polymerase chain reaction) RT-PCR and anti-S antibody tests. Among adults, the majority of participants were women (62%).Findings to dateWe enrolled 845 families from May 2020 to May 2022. The median number of residents per household was four. The median household density, defined as the number of persons per room, was 0.95. The risk of SARS-CoV-2 occurrence was higher in households with a high number of persons per room. Children were not the principal source of SARS-CoV-2 infections in their households during the first wave of the pandemic.Future plansFuture studies will investigate cellular and humoral immune responses to locally circulating SARS-CoV-2 variants, which is relevant for the design of vaccines, antivirals and monoclonal antibodies. We will also engage in outreach to encourage vaccination as a means of limiting the transmission of novel SARS-CoV-2 variants and other emerging pathogens.

Published
2022

3. Characteristics of women diagnosed with mpox infection compared to men: A case series from Brazil

Author

Accetta, André Figueiredo, Japiassu, André Miguel, Rendelli, Bruna, Santos, Desirée Vieira, Umaña Robleda, Gabriela Lisseth, Calvet, Guilherme Amaral, Pedroso Barbosa, Hugo Perazzo, Ferreira, Italo Guariz, Fagundes Neto, Jadir Rodrigues, Bortot Soares, João Paulo, Jaegger de França, João Victor, Hildebrant Coutinho, José Ricardo, Azevedo, Katia Maria, Villela, Larissa, Truccoli, Luciana, Fares, Luisa, Siqueira Camacho, Luiz Ricardo, Mesquita, Maira Braga, Cunha, Marcel, Trepow, Marcel, Terra, Marcela, Meneguetti, Maria Roberta, Castro de Souza Pires, Mariah, Amparo, Pedro, da Silva Martins, Pedro, Fraga, Rafael Teixeira, Menezes, Rodrigo Caldas, Otavio da Silva Escada, Rodrigo, Eiras, Rosangela Vieira, Pereira, Sandro Antônio, Davila da Silva, Wladmyr, Coutinho, Carolina, Secco Torres Silva, Mayara, Torres, Thiago S., Peixoto, Eduardo, Avelar Magalhães, Monica, Wagner Cardoso, Sandra, Nazário, Gabriela, Mendonça, Maíra, Menezes, Mariana, Almeida, Paula Maria, Dias de Brito de Carvalho, Paula Rita, Bia Bedin, Shenon, Almeida, Aline Maria, Carvalho, Silvia, Gonçalves Veloso, Valdilea, Grinsztejn, Beatriz, and Velasque, Luciane

Published
2023
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4. Detection and persistence of Zika virus in body fluids and associated factors: a prospective cohort study

Author

Calvet, Guilherme Amaral, Kara, Edna Oliveira, Bôtto-Menezes, Camila Helena Aguiar, da Costa Castilho, Marcia, de Oliveira Franca, Rafael Freitas, Habib, Ndema, Neto, Armando Menezes, Pereira, Gerson Fernando Mendes, Giozza, Silvana Pereira, Bermúdez, Ximena Pamela Díaz, Fernandes, Tatiana Jorge, Modjarrad, Kayvon, Brasil, Patrícia, Broutet, Nathalie Jeanne Nicole, and de Filippis, Ana Maria Bispo

Published
2023
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6. Myopericarditis associated with acute Zika virus infection: a case report

Author

Bôtto-Menezes, Camila Helena Aguiar, Safe, Izabella Picinin, da Cunha Ferreira, Ana Cláudia, do Nascimento Couceiro, Katia, Neto, Armando Menezes, Franca, Rafael Freitas Oliveira, Calvet, Guilherme Amaral, de Filippis, Ana Maria Bispo, Kara, Edna Oliveira, da Costa Castilho, Marcia, Bastos, Michele Souza, de Brito, Carlos Alexandre Antunes, Modjarrad, Kayvon, Broutet, Nathalie Jeanne Nicole, Brasil, Patrícia, Hajjar, Ludhmila Abrahão, and de Lacerda, Marcus Vinícius Guimarães

Published
2022
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7. A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014–2018)

Author

de Aguiar, Daniele Fernandes, de Barros, Eliana Nogueira C, Ribeiro, Guilherme Sousa, Brasil, Patricia, Mourao, Maria Paula Gomes, Luz, Kleber, Aoki, Francisco Hideo, Freitas, Andre Ricardo Ribas, Calvet, Guilherme Amaral, Oliveira, Eduardo, Branco, Bianca F, Abreu, Ariane, Cheuvart, Brigitte, Guignard, Adrienne, de Boer, Melanie, Duarte, Ana Claudia, Borges, Maria Beatriz, and de Noronha, Tatiana Guimarães

Published
2021
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8. Evidence of Zika Virus Reinfection by Genome Diversity and Antibody Response Analysis, Brazil

Author

da Costa Castilho, Marcia, primary, de Filippis, Ana Maria Bispo, additional, Machado, Lais Ceschini, additional, de Lima Calvanti, Thaise Yasmine Vasconcelos, additional, Lima, Morganna Costa, additional, Fonseca, Vagner, additional, Giovanetti, Marta, additional, Docena, Cassia, additional, Neto, Armando Menezes, additional, Bôtto-Menezes, Camila Helena Aguiar, additional, Kara, Edna Oliveira, additional, de La Barrera, Rafael, additional, Modjarrad, Kayvon, additional, Giozza, Silvana Pereira, additional, Pereira, Gerson Fernando, additional, Alcantara, Luiz Carlos Junior, additional, Broutet, Nathalie Jeanne Nicole, additional, Calvet, Guilherme Amaral, additional, Wallau, Gabriel Luz, additional, and Franca, Rafael Freitas Oliveira, additional

Published
2024
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9. Zika Virus in Rectal Swab Samples

Author

Botto-Menezes, Camila Helena Aguiar, Neto, Armando Menezes, Calvet, Guilherme Amaral, Kara, Edna Oliveira, Lacerda, Marcus Vinicius Guimaraes, Castilho, Marcia da Costa, Stroher, Ute, de Brito, Carlos Alexandre Antunes, Modjarrad, Kayvon, Broutet, Nathalie, Brasil, Patricia, de Filippis, Ana Maria Bispo, and Franca, Rafael Freitas Oliveira

Subjects
Prevention, Health aspects, Transcription (Genetics) -- Health aspects, Medical research -- Health aspects, Zika virus -- Health aspects, Infection -- Prevention -- Health aspects, Genetic disorders -- Prevention -- Health aspects, RNA -- Health aspects, Polymerase chain reaction
Abstract

In early 2015, Zika virus was identified in Brazil and spread across nearly the whole continent, affecting thousands of persons (1). This outbreak was associated with microcephaly and other congenital [...]

Published
2019
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10. Characteristics of women diagnosed with mpox infection compared to men: A case series from Brazil

Author

Coutinho, Carolina, primary, Secco Torres Silva, Mayara, additional, S. Torres, Thiago, additional, Peixoto, Eduardo, additional, Avelar Magalhães, Monica, additional, Wagner Cardoso, Sandra, additional, Nazário, Gabriela, additional, Mendonça, Maíra, additional, Menezes, Mariana, additional, Almeida, Paula Maria, additional, Dias de Brito de Carvalho, Paula Rita, additional, Bia Bedin, Shenon, additional, Almeida, Aline Maria, additional, Carvalho, Silvia, additional, Gonçalves Veloso, Valdilea, additional, Grinsztejn, Beatriz, additional, Velasque, Luciane, additional, Japiassu, André Miguel, additional, Trepow, Marcel, additional, Ferreira, Italo Guariz, additional, Villela, Larissa, additional, Fraga, Rafael Teixeira, additional, Castro de Souza Pires, Mariah, additional, da Silva Escada, Rodrigo Otavio, additional, Paiva de Sousa, Leonardo, additional, Robleda, Gabriela Lisseth Umaña, additional, Santos, Desirée Vieira, additional, Siqueira Camacho, Luiz Ricardo, additional, Amparo, Pedro, additional, de França, João Victor Jaegger, additional, de Oliveira Heluy Correa, Felipe, additional, de Sousa, Bruno Ivanovinsky Costa, additional, do Valle, Bernardo Vicari, additional, Soares, João Paulo Bortot, additional, Ferreira, Livia Cristina Fonseca, additional, da Silva Martins, Pedro, additional, Mesquita, Maira Braga, additional, Coutinho, José Ricardo Hildebrant, additional, de Moraes Perlingeiro, Raissa, additional, de Castro Oliveira, Priscila Peixoto, additional, Barbosa, Hugo Perazzo Pedroso, additional, Accetta, André Figueiredo, additional, Cunha, Marcelo, additional, Eiras, Rosangela Vieira, additional, Martins dos Santos, Ticiana, additional, Davila da Silva, Wladmyr, additional, Silveira, Monique do Vale, additional, de Souza Brum, Tania, additional, Calvet, Guilherme Amaral, additional, Menezes, Rodrigo Caldas, additional, and Pereira, Sandro Antônio, additional

Published
2023
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11. Paracoccidioidomycosis and pregnancy: A 40-year single-center cohort study in the endemic area of Rio de Janeiro, Brazil

Author

Benko, Lorena Macedo Pestana, primary, Vieira da Silva, Mariana Evangelista de Souza, additional, Falcão, Eduardo Mastrangelo Marinho, additional, Freitas, Dayvison Francis Saraiva, additional, Calvet, Guilherme Amaral, additional, Almeida, Marcos de Abreu, additional, Almeida-Paes, Rodrigo, additional, Zancopé-Oliveira, Rosely Maria, additional, do Valle, Antonio Carlos Francesconi, additional, and de Macedo, Priscila Marques, additional

Published
2023
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12. Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes

Author

Sankhala, Rajeshwer S., primary, Dussupt, Vincent, additional, Donofrio, Gina, additional, Gromowski, Gregory D., additional, De La Barrera, Rafael A., additional, Larocca, Rafael A., additional, Mendez-Rivera, Letzibeth, additional, Lee, Anna, additional, Choe, Misook, additional, Zaky, Weam, additional, Mantus, Grace, additional, Jensen, Jaime L., additional, Chen, Wei-Hung, additional, Gohain, Neelakshi, additional, Bai, Hongjun, additional, McCracken, Michael K., additional, Mason, Rosemarie D., additional, Leggat, David, additional, Slike, Bonnie M., additional, Tran, Ursula, additional, Jian, Ningbo, additional, Abbink, Peter, additional, Peterson, Rebecca, additional, Mendes, Eric Araujo, additional, Freitas de Oliveira Franca, Rafael, additional, Calvet, Guilherme Amaral, additional, Bispo de Filippis, Ana Maria, additional, McDermott, Adrian, additional, Roederer, Mario, additional, Hernandez, Mayda, additional, Albertus, Amie, additional, Davidson, Edgar, additional, Doranz, Benjamin J., additional, Rolland, Morgane, additional, Robb, Merlin L., additional, Lynch, Rebecca M., additional, Barouch, Dan H., additional, Jarman, Richard G., additional, Thomas, Stephen J., additional, Modjarrad, Kayvon, additional, Michael, Nelson L., additional, Krebs, Shelly J., additional, and Joyce, M. Gordon, additional

Published
2023
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13. Zika Virus Infection and Differential Diagnosis in A Cohort of HIV-Infected Patients

Author

Calvet, Guilherme Amaral, Brasil, Patricia, Siqueira, Andre Machado, Zogbi, Heruza Einsfeld, de Santis Gonçalves, Bianca, da Silva Santos, Aline, Lupi, Otilia, Valls de Souza, Rogerio, Santos Rodrigues, Cintia Damasceno dos, da Silveira Bressan, Clarisse, Wakimoto, Mauymi Duarte, de Araújo, Eliane Saraiva, Santos, Ingrid Cardoso dos, Georg, Ingebourg, Ribeiro Nogueira, Rita Maria, Veloso, Valdilea Gonçalves, and Bispo de Filippis, Ana Maria

Published
2018
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14. Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance

Author

Bressan, Clarisse da Silveira, primary, Teixeira, Maria de Lourdes Benamor, additional, Gouvêa, Maria Isabel Fragoso da Silveira, additional, de Pina-Costa, Anielle, additional, Santos, Heloísa Ferreira Pinto, additional, Calvet, Guilherme Amaral, additional, Lupi, Otilia, additional, Siqueira, Andre Machado, additional, Valls-de-Souza, Rogério, additional, Valim, Clarissa, additional, and Brasil, Patrícia, additional

Published
2023
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15. Ambulatory and hospitalized patients with suspected and confirmed mpox: an observational cohort study from Brazil

Author

Silva, Mayara Secco Torres, primary, Coutinho, Carolina, additional, Torres, Thiago Silva, additional, Peixoto, Eduardo, additional, Ismério, Ronaldo, additional, Lessa, Flavia, additional, Nunes, Estevão Portela, additional, Hoagland, Brenda, additional, Echeverria Guevara, Amanda Dolores, additional, Bastos, Matheus Oliveira, additional, Ferreira Tavares, Isabel Cristina, additional, Diniz Ribeiro, Maria Pia, additional, Meneguetti Seravalli Ramos, Maria Roberta, additional, Andrade, Hugo Boechat, additional, Lovetro Santana, Ana Paula, additional, Santini-Oliveira, Marilia, additional, Santos Netto, Juliana Barbosa, additional, Reges, Paula, additional, Magalhães, Monica Avelar, additional, Silva Rosadas, Leonardo Azevedo, additional, Nazer, Sandro, additional, Velasque, Luciane, additional, Cardoso, Sandra Wagner, additional, da Silva, Edson Elias, additional, Veloso, Valdilea Gonçalves, additional, Wakimoto, Mayumi Duarte, additional, Grinsztejn, Beatriz, additional, Japiassu, André Miguel, additional, Trepow, Marcel, additional, Ferreira, Italo Guariz, additional, Villela, Larissa, additional, Fraga, Rafael Teixeira, additional, Castro de Souza Pires, Mariah, additional, Otavio da Silva Escada, Rodrigo, additional, Paiva de Sousa, Leonardo, additional, Umaña Robleda, Gabriela Lisseth, additional, Santos, Desirée Vieira, additional, Siqueira Camacho, Luiz Ricardo, additional, Amparo, Pedro, additional, Jaegger de França, João Victor, additional, de Oliveira Heluy Correa, Felipe, additional, Costa de Sousa, Bruno Ivanovinsky, additional, Vicari do Valle, Bernardo, additional, Bortot Soares, João Paulo, additional, Fonseca Ferreira, Livia Cristina, additional, da Silva Martins, Pedro, additional, Mesquita, Maira Braga, additional, Hildebrant Coutinho, José Ricardo, additional, de Moraes Perlingeiro, Raissa, additional, Peixoto de Castro Oliveira, Priscila, additional, Pedroso Barbosa, Hugo Perazzo, additional, Accetta, André Figueiredo, additional, Cunha, Marcelo, additional, Eiras, Rosangela Vieira, additional, Martins dos Santos, Ticiana, additional, Davila da Silva, Wladmyr, additional, Silveira, Monique do Vale, additional, de Souza Brum, Tania, additional, Calvet, Guilherme Amaral, additional, Menezes, Rodrigo Caldas, additional, and Pereira, Sandro Antônio, additional

Published
2023
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16. Long COVID-19 syndrome associated with Omicron XBB.1.5 infection: a case report

Author

Espíndola, Otávio, primary, Resende, Paola C, additional, Guaraldo, Lusiele, additional, Calvet, Guilherme Amaral, additional, Fuller, Trevon L, additional, Penetra, Stephanie Lema Suarez, additional, Santos, Heloisa Ferreira Pinto, additional, Pina-Costa, Anielle, additional, da Silva, Michele Fernanda Borges, additional, Moraes, Isabella Campos Vargas, additional, Medeiros, Fernando, additional, Whitworth, Jimmy, additional, Smith, Christopher, additional, Nielsen-Saines, Karin, additional, Siqueira, Marilda M, additional, and Brasil, Patrícia, additional

Published
2023
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17. Fatal Brazilian spotted fever in a healthy military man during field training in Rio de Janeiro city, southeastern Brazil

Author

Pacheco-Silva, Ana Beatriz, Martins, Ezequias Batista, López, Angie Jeannine Rios, Detepo, Paula João Tomas, Mamani, Roxana Flores, Japiassú, André Miguel, Lupi, Otilia, Mendes, Tulio Vieira, Pina-Costa, Anielle de, Calvet, Guilherme Amaral, Bressan, Clarisse da Silveira, Silva, Michele Fernanda Borges da, Ogino, Liana Lumi, Assis, Matheus Ribeiro da Silva, Marques, Amanda Meneleu, Dias, Cristina Maria Giordano, Borchert, Juliana Mildward, Lemos, Elba Regina Sampaio de, and Brasil, Patrícia

Subjects
Capybaras, Vector-borne, Rickettsia infection, Rio de Janeiro city, Spotted fever
Abstract

Brazilian spotted fever, a zoonotic disease transmitted by ticks, is caused by Rickettsia rickettsii. We report a fulminant case of this zoonosis in a healthy 46-year-old military man in the urban region of Rio de Janeiro city, in October, 2021. Ticks and capybaras (Amblyomma sculptum, Hydrochoerus hydrochaeris, respectively) were identified in the military fields, pointing to the participation of this large synanthropic rodent, recognized as an efficient amplifier host of Rickettsia rickettsii in Brazil. As the military population is considered a risk group for spotted fever, it is necessary to alert health professionals to the importance of the early detection of the disease and its adequate management, mainly in populations that are particularly at risk of exposure to ticks, in order to avoid fatal outcomes.

Published
2022

18. Beyond arboviruses: A multicenter study to evaluate differential diagnosis of rash diseases and acute febrile illness cases in Rio de Janeiro, Brazil

Author

Alves, Arthur Daniel Rocha, primary, Raposo, Jéssica Vasques, additional, de Sousa, Rafaela Moraes Pereira, additional, Cardoso, Claudete Aparecida Araújo, additional, Costa, Pâmela Karla Simões de Freitas, additional, Araújo, Julienne Martins, additional, Barreiro, Sabrina Teresinha Alvim, additional, Bressan, Clarisse da Silveira, additional, Calvet, Guilherme Amaral, additional, de Souza, Rogério Valls, additional, Brasil, Patrícia, additional, Cubel Garcia, Rita de Cássia Nasser, additional, Pinto, Marcelo Alves, additional, de Paula, Vanessa Salete, additional, and Amado, Luciane Almeida, additional

Published
2022
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22. Fatal Brazilian spotted fever in a healthy military man during field training in Rio de Janeiro city, southeastern Brazil

Author

Pacheco-Silva, Ana Beatriz, primary, Martins, Ezequias Batista, additional, López, Angie Jeannine Rios, additional, Detepo, Paula João Tomas, additional, Mamani, Roxana Flores, additional, Japiassú, André Miguel, additional, Lupi, Otilia, additional, Mendes, Tulio Vieira, additional, Pina-Costa, Anielle de, additional, Calvet, Guilherme Amaral, additional, Bressan, Clarisse da Silveira, additional, Silva, Michele Fernanda Borges da, additional, Ogino, Liana Lumi, additional, Assis, Matheus Ribeiro da Silva, additional, Marques, Amanda Meneleu, additional, Dias, Cristina Maria Giordano, additional, Borchert, Juliana Mildward, additional, Lemos, Elba Regina Sampaio de, additional, and Brasil, Patrícia, additional

Published
2022
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24. Investigation of SARS-CoV-2 infection in dogs and cats of humans diagnosed with COVID-19 in Rio de Janeiro, Brazil

Author

Calvet, Guilherme Amaral, primary, Pereira, Sandro Antonio, additional, Ogrzewalska, Maria, additional, Pauvolid-Corrêa, Alex, additional, Resende, Paola Cristina, additional, Tassinari, Wagner de Souza, additional, Costa, Anielle de Pina, additional, Keidel, Lucas Oliveira, additional, da Rocha, Alice Sampaio Barreto, additional, da Silva, Michele Fernanda Borges, additional, dos Santos, Shanna Araujo, additional, Lima, Ana Beatriz Machado, additional, de Moraes, Isabella Campos Vargas, additional, Mendes Junior, Artur Augusto Velho, additional, Souza, Thiago das Chagas, additional, Martins, Ezequias Batista, additional, Ornellas, Renato Orsini, additional, Corrêa, Maria Lopes, additional, Antonio, Isabela Maria da Silva, additional, Guaraldo, Lusiele, additional, Motta, Fernando do Couto, additional, Brasil, Patrícia, additional, Siqueira, Marilda Mendonça, additional, Gremião, Isabella Dib Ferreira, additional, and Menezes, Rodrigo Caldas, additional

Published
2021
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26. Zika virus RNA excretion in sweat with concomitant detection in other body fluid specimens

Author

Menezes-Neto, Armando, primary, Castilho, Marcia da Costa, additional, Calvet, Guilherme Amaral, additional, Kara, Edna Oliveira, additional, Bôtto-Menezes, Camila Helena Aguiar, additional, Lacerda, Marcus Vinícius Guimarães, additional, Pereira, Gerson Fernando Mendes, additional, Giozza, Silvana Pereira, additional, Bermudez, Ximena Pamela Diaz, additional, Lima, Noemia Santana, additional, Modjarrad, Kayvon, additional, Broutet, Nathalie, additional, de Filippis, Ana Maria Bispo, additional, and Franca, Rafael Freitas Oliveira, additional

Published
2020
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27. Diagnostic performance of anti-Zika virus IgM, IgAM and IgG ELISAs during co-circulation of Zika, dengue, and chikungunya viruses in Brazil and Venezuela.

Author

Morales, Ivonne, Rosenberger, Kerstin D., Magalhaes, Tereza, Morais, Clarice N. L., Braga, Cynthia, Marques, Ernesto T. A., Calvet, Guilherme Amaral, Damasceno, Luana, Brasil, Patricia, Bispo de Filippis, Ana Maria, Bethencourt, Sarah, Tami, Adriana, Alvarez, Mayling, Martínez, Pedro A., Guzmán, María G., Souza Benevides, Bruno, Caprara, Andrea, Quyen, Nguyen Thanh Ha, Simmons, Cameron, and Wills, Bridget

Subjects
IMMUNOGLOBULIN G, CHIKUNGUNYA virus, ZIKA virus infections, DIAGNOSIS, DENGUE
Abstract

Background: Serological diagnosis of Zika virus (ZIKV) infection is challenging because of the antibody cross-reactivity among flaviviruses. At the same time, the role of Nucleic Acid Testing (NAT) is limited by the low proportion of symptomatic infections and the low average viral load. Here, we compared the diagnostic performance of commercially available IgM, IgAM, and IgG ELISAs in sequential samples during the ZIKV and chikungunya (CHIKV) epidemics and co-circulation of dengue virus (DENV) in Brazil and Venezuela. Methodology/Principal findings: Acute (day of illness 1–5) and follow-up (day of illness ≥ 6) blood samples were collected from nine hundred and seven symptomatic patients enrolled in a prospective multicenter study of symptomatic patients recruited between June 2012 and August 2016. Acute samples were tested by RT-PCR for ZIKV, DENV, and CHIKV. Acute and follow-up samples were tested for IgM, IgAM, and IgG antibodies to ZIKV using commercially available ELISAs. Among follow-up samples with a RT-PCR confirmed ZIKV infection, anti-ZIKV IgAM sensitivity was 93.5% (43/48), while IgM and IgG exhibited sensitivities of 30.3% (10/35) and 72% (18/25), respectively. An additional 24% (26/109) of ZIKV infections were detected via IgAM seroconversion in ZIKV/DENV/CHIKV RT-PCR negative patients. The specificity of anti-ZIKV IgM was estimated at 93% and that of IgAM at 85%. Conclusions/Significance: Our findings exemplify the challenges of the assessment of test performance for ZIKV serological tests in the real-world setting, during co-circulation of DENV, ZIKV, and CHIKV. However, we can also demonstrate that the IgAM immunoassay exhibits superior sensitivity to detect ZIKV RT-PCR confirmed infections compared to IgG and IgM immunoassays. The IgAM assay also proves to be promising for detection of anti-ZIKV seroconversions in sequential samples, both in ZIKV PCR-positive as well as PCR-negative patients, making this a candidate assay for serological monitoring of pregnant women in future ZIKV outbreaks. Author summary: Zika virus (ZIKV) is transmitted through the bite of infected Aedes mosquitos but can also be transmitted sexually or vertically from mother-to-child. The same mosquitoes transmit dengue virus (DENV) and chikungunya virus (CHIKV), which cause similar clinical syndromes. The ZIKV epidemics in the Pacific and the Americas that occurred between 2015 and 2017 were linked to congenital abnormalities, most prominently microcephaly, in newborns. Because most infections are asymptomatic, diagnosis via indirect serological assays is an important strategy. On the other hand, many serological assays are affected by cross-reactivity resulting from prior infections by closely related viruses, such as DENV. This study evaluated three commercially available and widely used immunoassays that detect IgG, IgM or IgA and M (IgAM) antibodies to ZIKV. Our results suggest that the IgAM test performs best by detecting around 90% of RT-PCR confirmed infections. We also detected additional infections that were not detected by RT-PCR. The strength of this study is that it was carried out in two different countries of the American region where several arboviruses are endemic and that sequential blood samples from individual patients were available to evaluate the performance of the tests over time. [ABSTRACT FROM AUTHOR]

Published
2021
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28. An initiative of cooperation in Zika virus research: the experience of the ZIKABRA study in Brazil.

Author

Giozza, Silvana Pereira, Bermúdez, Ximena Pamela Díaz, Kara, Edna Oliveira, Calvet, Guilherme Amaral, de Filippis, Ana Maria Bispo, Lacerda, Marcus Vinícius Guimarães, Bôtto-Menezes, Camila Helena Aguiar, da Costa Castilho, Marcia, Franca, Rafael Freitas Oliveira, Neto, Armando Menezes, Storme, Casey, Lima, Noemia S., Modjarrad, Kayvon, de Oliveira, Maria Cristina Pimenta, Pereira, Gerson Fernando Mendes, Broutet, Nathalie, on behalf of ZIKABRA Study Team, de Abreu, André Luiz, Brasil, Patrícia, and Brito, Carlos Alexandre Antunes

Subjects
ZIKA virus, PUBLIC health, INTERNATIONAL cooperation on public health, VIRUS disease transmission, EMERGENCY management, INTERNATIONAL agencies
Abstract

Background: The Zika virus outbreak has triggered a set of local and global actions for a rapid, effective, and timely public health response. A World Health Organization (WHO) initiative, supported by the Department of Chronic Condition Diseases and Sexually Transmitted Infections (DCCI) of the Health Surveillance Secretariat (SVS), Brazil Ministry of Health (MoH) and other public health funders, resulted in the start of the "Study on the persistence of Zika virus in body fluids of patients with ZIKV infection in Brazil - ZIKABRA study". The ZIKABRA study was designed to increase understanding of how long ZIKV persists in bodily fluids and informing best measures to prevent its transmission. Data collection began in July 2017 and the last follow up visit occurred in 06/26/2020.Methods: A framework for the ZIKABRA Cooperation initiative is provided through a description and analysis of the mechanisms, strategies and the ethos that have guided the models of international governance and technical cooperation in health for scientific exchange in the context of a public health emergency. Among the methodological strategies, we included a review of the legal documents that supported the ZIKABRA Cooperation; weekly documents produced in the meetings and working sessions; technical reports; memorandum of understanding and the research protocol.Conclusion: We highlight the importance of working in cooperation between different institutional actors to achieve more significant results than that obtained by each group working in isolation. In addition, we point out the advantages of training activities, ongoing supervision, the construction of local installed research capacity, training academic and non-academic human resources, improvement of laboratory equipment, knowledge transfer and the availability of the ZIKABRA study protocol for development of similar studies, favoring the collective construction of knowledge to provide public health emergency responses. Strategy harmonization; human resources and health services; timing and recruiting particularities and processing institutional clearance in the different sites can be mentioned as challenges in this type of initiative. [ABSTRACT FROM AUTHOR]

Published
2021
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29. Cohort profile: Study on Zika virus infection in Brazil (ZIKABRA study).

Author

Calvet, Guilherme Amaral, Kara, Edna Oliveira, Landoulsi, Sihem, Habib, Ndema, Bôtto-Menezes, Camila Helena Aguiar, Franca, Rafael Freitas de Oliveira, Neto, Armando Menezes, Castilho, Marcia da Costa, Fernandes, Tatiana Jorge, Pereira, Gerson Fernando, Giozza, Silvana Pereira, Bermúdez, Ximena Pamela Díaz, Modjarrad, Kayvon, Lima, Noemia, Brasil, Patrícia, de Lacerda, Marcus Vinicius Guimarães, de Filippis, Ana Maria Bispo, and Broutet, Nathalie Jeanne Nicole

Subjects
*ZIKA virus infections, *CEREBROSPINAL fluid, *AMNIOTIC liquid, *SALIVA, *SEMEN, *COHORT analysis, *ITCHING
Abstract

Zika virus (ZIKV) has been detected in blood, urine, semen, cerebral spinal fluid, saliva, amniotic fluid, and breast milk. In most ZIKV infected individuals, the virus is detected in the blood to one week after the onset of symptoms and has been found to persist longer in urine and semen. To better understand virus dynamics, a prospective cohort study was conducted in Brazil to assess the presence and duration of ZIKV and related markers (viral RNA, antibodies, T cell response, and innate immunity) in blood, semen, saliva, urine, vaginal secretions/menstrual blood, rectal swab and sweat. The objective of the current manuscript is to describe the cohort, including an overview of the collected data and a description of the baseline characteristics of the participants. Men and women ≥ 18 years with acute illness and their symptomatic and asymptomatic household contacts with positive reverse transcriptase-polymerase chain reaction test for ZIKV in blood and/or urine were included. All participants were followed up for 12 months. From July 2017 to June 2019, a total of 786 participants (284 men, 502 women) were screened. Of these, 260 (33.1%) were enrolled in the study; index cases: 64 men (24.6%), 162 (62.3%) women; household contacts: 12 men (4.6%), 22 (8.5%) women. There was a statistically significant difference in age and sex between enrolled and not enrolled participants (p<0.005). Baseline sociodemographic and medical data were collected at enrollment from all participants. The median and interquartile range (IQR) age was 35 (IQR; 25.3, 43) for men and 36.5 years (IQR; 28, 47) for women. Following rash, which was one of the inclusion criteria for index cases, the most reported symptoms in the enrollment visit since the onset of the disease were fever, itching, arthralgia with or without edema, non-purulent conjunctivitis, headache, and myalgia. Ten hospitalizations were reported by eight patients (two patients were hospitalized twice) during follow up, after a median of 108 days following symptom onset (range 7 to 266 days) and with a median of 1.5 days (range 1 to 20 days) of hospital stay. A total of 4,137 visits were performed, 223 (85.8%) participants have attended all visits and 37 (14.2%) patients were discontinued. [ABSTRACT FROM AUTHOR]

Published
2021
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31. Zika Virus Outbreak in Rio de Janeiro, Brazil : Clinical Characterization, Epidemiological and Virological Aspects

Author

Calvet, Guilherme Amaral and Brasil, Patricia

Abstract

In 2015, Brazil was faced with the cocirculation of three arboviruses of major public health importance. The emergence of Zika virus (ZIKV) presents new challenges to both clinicians and public health authorities. Overlapping clinical features between diseases caused by ZIKV, Dengue (DENV) and Chikungunya (CHIKV) and the lack of validated serological assays for ZIKV make accurate diagnosis difficult.

Published
2016

32. Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics

Author

Braga, José Ueleres, primary, Bressan, Clarisse, additional, Dalvi, Ana Paula Razal, additional, Calvet, Guilherme Amaral, additional, Daumas, Regina Paiva, additional, Rodrigues, Nadia, additional, Wakimoto, Mayumi, additional, Nogueira, Rita Maria Ribeiro, additional, Nielsen-Saines, Karin, additional, Brito, Carlos, additional, Bispo de Filippis, Ana Maria, additional, and Brasil, Patrícia, additional

Published
2017
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33. Zika Virus in Rectal Swab Samples.

Author

Aguiar Bôtto-Menezes, Camila Helena, Neto, Armando Menezes, Calvet, Guilherme Amaral, Kara, Edna Oliveira, Guimarães Lacerda, Marcus Vinícius, da Costa Castilho, Marcia, Ströher, Ute, de Brito, Carlos Alexandre Antunes, Modjarrad, Kayvon, Broutet, Nathalie, Brasil, Patrícia, de Filippis, Ana Maria Bispo, Oliveira Franca, Rafael Freitas, Bôtto-Menezes, Camila Helena Aguiar, Lacerda, Marcus Vinícius Guimarães, Castilho, Marcia da Costa, Antunes de Brito, Carlos Alexandre, Bispo de Filippis, Ana Maria, Franca, Rafael Freitas Oliveira, and ZIKABRA Study Team

Subjects
ZIKA virus, RNA viruses, INFECTION prevention
Abstract

We detected Zika virus RNA in rectal swab samples from 10 patients by using real-time reverse transcription PCR, and we isolated the virus from 1 patient. The longest interval from symptom onset to detection was 14 days. These findings are applicable to diagnosis and infection prevention recommendations. [ABSTRACT FROM AUTHOR]

Published
2019
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34. Zika virus infection

Author

Calvet, Guilherme Amaral, primary, Santos, Flavia Barreto dos, additional, and Sequeira, Patricia Carvalho, additional

Published
2016
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35. Zika Virus Outbreak in Rio de Janeiro, Brazil: Clinical Characterization, Epidemiological and Virological Aspects

Author

Brasil, Patrícia, primary, Calvet, Guilherme Amaral, additional, Siqueira, André Machado, additional, Wakimoto, Mayumi, additional, de Sequeira, Patrícia Carvalho, additional, Nobre, Aline, additional, Quintana, Marcel de Souza Borges, additional, Mendonça, Marco Cesar Lima de, additional, Lupi, Otilia, additional, de Souza, Rogerio Valls, additional, Romero, Carolina, additional, Zogbi, Heruza, additional, Bressan, Clarisse da Silveira, additional, Alves, Simone Sampaio, additional, Lourenço-de-Oliveira, Ricardo, additional, Nogueira, Rita Maria Ribeiro, additional, Carvalho, Marilia Sá, additional, de Filippis, Ana Maria Bispo, additional, and Jaenisch, Thomas, additional

Published
2016
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36. Guillain-Barré syndrome associated with Zika virus infection

Author

Brasil, Patrícia, primary, Sequeira, Patricia Carvalho, additional, Freitas, Andrea D'Avila, additional, Zogbi, Heruza Einsfeld, additional, Calvet, Guilherme Amaral, additional, de Souza, Rogerio Valls, additional, Siqueira, André Machado, additional, de Mendonca, Marcos Cesar Lima, additional, Nogueira, Rita Maria Ribeiro, additional, de Filippis, Ana Maria Bispo, additional, and Solomon, Tom, additional

Published
2016
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38. Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil.

Author

Calvet, Guilherme Amaral, Kara, Edna Oliveira, Giozza, Silvana Pereira, Bôtto-Menezes, Camila Helena Aguiar, Gaillard, Philippe, de Oliveira Franca, Rafael Freitas, de Lacerda, Marcus Vinicius Guimarães, da Costa Castilho, Marcia, Brasil, Patrícia, de Sequeira, Patrícia Carvalho, de Mello, Maeve Brito, Bermudez, Ximena Pamela Diaz, Modjarrad, Kayvon, Meurant, Robyn, Landoulsi, Sihem, Benzaken, Adele Schwartz, de Filippis, Ana Maria Bispo, Broutet, Nathalie Jeanne Nicole, and ZIKABRA Study Team

Subjects
*ZIKA virus infections, *ZIKA virus, *REVERSE transcriptase polymerase chain reaction, *RNA sequencing, *BLOOD testing, *DIAGNOSIS, *VIRAL transmission, *BODY fluids, *BREAST milk, *COMPARATIVE studies, *DENGUE, *IMMUNOGLOBULINS, *LONGITUDINAL method, *RESEARCH methodology, *MEDICAL cooperation, *RESEARCH, *RESEARCH funding, *SEMEN, *EVALUATION research, *CHIKUNGUNYA, *NEUTRALIZATION tests, *MIXED infections
Abstract

Background: Zika virus (ZIKV) has been identified in several body fluids of infected individuals. In most cases, it remained detected in blood from few days to 1 week after the onset of symptoms, and can persist longer in urine and in semen. ZIKV infection can have dramatic consequences such as microcephaly and Guillain-Barré syndrome. ZIKV sexual transmission has been documented. A better understanding of ZIKV presence and persistence across biologic compartments is needed to devise rational measures to prevent its transmission.Methods: This observational cohort study will recruit non-pregnant participants aged 18 years and above with confirmed ZIKV infection [positive reverse transcriptase-polymerase chain reaction (RT-PCR) test in blood and/or urine]: symptomatic men and women in ZIKV infection acute phase, and their symptomatic or asymptomatic household/sexual infected contacts. Specimens of blood, urine, semen, vaginal secretion/menstrual blood, rectal swab, oral fluids, tears, sweat, urine and breast milk (if applicable) will be collected at pre-established intervals and tested for ZIKV RNA presence by RT-PCR, other co-infection (dengue, Chikungunya, HIV, hepatitis B and C, syphilis), antibody response (including immunoglobulins M and G), plaque reduction neutralization test (if simultaneously positive for ZIKV and dengue), and ZIKV culture and RNA sequencing. Data on socio-demographic characteristics and comorbidities will be collected in parallel. Participants will be followed up for 12 months.Discussion: This prolonged longitudinal follow-up of ZIKV infected persons with regular biologic testing and data collection will offer a unique opportunity to investigate the presence and persistence of ZIKV in various biologic compartments, their clinical and immunological correlates as well as the possibility of ZIKV reactivation/reinfection over time. This valuable information will substantially contribute to the body of knowledge on ZIKV infection and serve as a base for the development of more effective recommendation on the prevention of ZIKV transmission.Trial Registration: NCT03106714 . Registration Date: April, 7, 2017. [ABSTRACT FROM AUTHOR]

Published
2018
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39. Absence of Effect of Menopause Status at Initiation of First-Line Antiretroviral Therapy on Immunologic or Virologic Responses: A Cohort Study from Rio de Janeiro, Brazil

Author

Calvet, Guilherme Amaral, primary, Velasque, Luciane, additional, Luz, Paula Mendes, additional, Cardoso, Sandra Wagner, additional, Derrico, Monica, additional, Moreira, Ronaldo Ismério, additional, de Andrade, Angela Cristina Vasconcelos, additional, Cytryn, Andrea, additional, Pires, Elaine, additional, Veloso, Valdiléa Gonçalves, additional, Grinsztejn, Beatriz, additional, and Friedman, Ruth Khalili, additional

Published
2014
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42. Trends in a Cohort of HIV-infected pregnant women in Rio de Janeiro, 1996-2004

Author

Calvet, Guilherme Amaral, primary, João, Esaú Custódio, additional, Nielsen-Saines, Karin, additional, Cunha, Cynthia Braga, additional, Menezes, Jacqueline Anita, additional, d'Ippolito, Marcos Machado, additional, Cruz, Maria Letícia Santos, additional, Martins, Ezequias Batista, additional, Silva, Sônia Maria Santos, additional, Medeiros, Adriana Ferreira, additional, and Matos, Haroldo José, additional

Published
2007
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46. Adesão ao pré-natal de mulheres HIV+ que não fizeram profilaxia da transmissão vertical: um estudo sócio-comportamental e de acesso ao sistema de saúde.

Author

Rocha Darmont, Mariana de Queiroz, Martins, Helena Santos, Calvet, Guilherme Amaral, Deslandes, Suely Ferreira, and de Menezes, Jacqueline Anita

Abstract

Copyright of Cadernos de Saude Publica is the property of Escola Nacional de Saude Publica Sergio Arouca and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2010
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47. Chikungunya: an arbovirus infection in the process of establishment and expansion in Brazil.

Author

Honório, Nildimar Alves, Portela Câmara, Daniel Cardoso, Calvet, Guilherme Amaral, and Brasil, Patrícia

Abstract

The article argues on mosquito-borne arboviruses such as dengue virus (DENV) and chikungunya virus (CHIKV) epidemics in Brazil which are both transmitted by mosquitoes of the genus Aedes (Ae) particularly Ae. aegypti and Ae. albopictus.

Published
2015
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49. Ambulatory and hospitalized patients with suspected and confirmed mpox: An observational cohort study from Brazil

Author

Silva, Mayara Secco Torres, Coutinho, Carolina, Torres, Thiago Silva, Peixoto, Eduardo, Ismério, Ronaldo, Lessa, Flavia, Nunes, Estevão Portela, Hoagland, Brenda, Echeverria Guevara, Amanda Dolores, Bastos, Matheus Oliveira, Ferreira Tavares, Isabel Cristina, Diniz Ribeiro, Maria Pia, Meneguetti Seravalli Ramos, Maria Roberta, Andrade, Hugo Boechat, Lovetro Santana, Ana Paula, Santini-Oliveira, Marilia, Santos Netto, Juliana Barbosa, Reges, Paula, Magalhães, Monica Avelar, Silva Rosadas, Leonardo Azevedo, Nazer, Sandro, Velasque, Luciane, Cardoso, Sandra Wagner, da Silva, Edson Elias, Veloso, Valdilea Gonçalves, Wakimoto, Mayumi Duarte, Grinsztejn, Beatriz, Japiassu, André Miguel, Trepow, Marcel, Ferreira, Italo Guariz, Villela, Larissa, Fraga, Rafael Teixeira, Castro de Souza Pires, Mariah, Otavio da Silva Escada, Rodrigo, Paiva de Sousa, Leonardo, Umaña Robleda, Gabriela Lisseth, Santos, Desirée Vieira, Siqueira Camacho, Luiz Ricardo, Amparo, Pedro, Jaegger de França, João Victor, de Oliveira Heluy Correa, Felipe, Costa de Sousa, Bruno Ivanovinsky, Vicari do Valle, Bernardo, Bortot Soares, João Paulo, Fonseca Ferreira, Livia Cristina, da Silva Martins, Pedro, Mesquita, Maira Braga, Hildebrant Coutinho, José Ricardo, de Moraes Perlingeiro, Raissa, Peixoto de Castro Oliveira, Priscila, Pedroso Barbosa, Hugo Perazzo, Accetta, André Figueiredo, Cunha, Marcelo, Eiras, Rosangela Vieira, Martins dos Santos, Ticiana, Davila da Silva, Wladmyr, Silveira, Monique do Vale, de Souza Brum, Tania, Calvet, Guilherme Amaral, Menezes, Rodrigo Caldas, and Pereira, Sandro Antônio

Abstract

By October 30, 2022, 76,871 cases of mpox were reported worldwide, with 20,614 cases in Latin America. This study reports characteristics of a case series of suspected and confirmed mpox cases at a referral infectious diseases center in Rio de Janeiro, Brazil.

Published
2022
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