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Your search keyword '"Cambier, C.J."' showing total 13 results
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13 results on '"Cambier, C.J."'

1. Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids

Author

Cambier, C.J., Takaki, Kevin K., Larson, Ryan P., Hernandez, Rafael E., Tobin, David M., Urdahl, Kevin B., Cosma, Christine L., and Ramakrishnan, Lalita

Subjects
Membrane lipids -- Properties, Mycobacterial infections -- Development and progression -- Physiological aspects, Macrophages -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The evolutionary survival of Mycobacterium tuberculosis, the cause of human tuberculosis, depends on its ability to invade the host, replicate, and transmit infection. At its initial peripheral infection site in [...]

Published
2014
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3. Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling

Author

Walton, Eric M., primary, Cronan, Mark R., additional, Cambier, C.J., additional, Rossi, Andrea, additional, Marass, Michele, additional, Foglia, Matthew D., additional, Brewer, W. Jared, additional, Poss, Kenneth D., additional, Stainier, Didier Y.R., additional, Bertozzi, Carolyn R., additional, and Tobin, David M., additional

Published
2018
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4. Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration

Author

Berg, Russell D., Levitte, Steven, O’Sullivan, Mary P., O’Leary, Seónadh M., Cambier, C.J., Cameron, James, Takaki, Kevin K., Moens, Cecilia B., Tobin, David M., Keane, Joseph, Ramakrishnan, Lalita, Takaki, Kevin [0000-0002-4790-4598], Ramakrishnan, Lalita [0000-0003-0692-5533], and Apollo - University of Cambridge Repository

Subjects
Mycobacterium Infections, Granuloma, Biochemistry, Genetics and Molecular Biology(all), Macrophages, Smoking, Mycobacterium Infections, Nontuberculous, Zebrafish Proteins, Article, Mycobacterium, Pulmonary Alveoli, Macrophages, Alveolar, Mycobacterium marinum, Humans, Animals, Tuberculosis, Disease Susceptibility, Lysosomes, Transport Vesicles, Zebrafish, Transcription Factors
Abstract

Summary A zebrafish genetic screen for determinants of susceptibility to Mycobacterium marinum identified a hypersusceptible mutant deficient in lysosomal cysteine cathepsins that manifests hallmarks of human lysosomal storage diseases. Under homeostatic conditions, mutant macrophages accumulate undigested lysosomal material, which disrupts endocytic recycling and impairs their migration to, and thus engulfment of, dying cells. This causes a buildup of unengulfed cell debris. During mycobacterial infection, macrophages with lysosomal storage cannot migrate toward infected macrophages undergoing apoptosis in the tuberculous granuloma. The unengulfed apoptotic macrophages undergo secondary necrosis, causing granuloma breakdown and increased mycobacterial growth. Macrophage lysosomal storage similarly impairs migration to newly infecting mycobacteria. This phenotype is recapitulated in human smokers, who are at increased risk for tuberculosis. A majority of their alveolar macrophages exhibit lysosomal accumulations of tobacco smoke particulates and do not migrate to Mycobacterium tuberculosis. The incapacitation of highly microbicidal first-responding macrophages may contribute to smokers’ susceptibility to tuberculosis., Graphical Abstract, Highlights • Lysosomal storage diseases reduce macrophage endocytic recycling and migration • Reduced macrophage migration increases tuberculosis severity via granuloma breakdown • Tobacco smoke particles accumulate in lysosomes of smokers’ alveolar macrophages • Lysosomal particles reduce smokers’ macrophage migration to infecting mycobacteria, Lysosomal dysfunction caused by genetic mutations or accumulation of tobacco particulates in the lysosomal compartment impairs macrophage function and formation of stable tuberculous granulomas, providing a possible explanation for the increased susceptibility to tuberculosis in smokers.

Published
2016

6. A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy

Author

Madigan, Cressida A., primary, Cambier, C.J., additional, Kelly-Scumpia, Kindra M., additional, Scumpia, Philip O., additional, Cheng, Tan-Yun, additional, Zailaa, Joseph, additional, Bloom, Barry R., additional, Moody, D. Branch, additional, Smale, Stephen T., additional, Sagasti, Alvaro, additional, Modlin, Robert L., additional, and Ramakrishnan, Lalita, additional

Published
2017
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8. A macrophage response toMycobacterium lepraephenolic glycolipid initiates nerve damage in leprosy

Author

Madigan, Cressida A., primary, Cambier, C.J., additional, Kelly-Scumpia, Kindra M., additional, Scumpia, Philip O., additional, Cheng, Tan-Yun, additional, Zailaa, Joseph, additional, Bloom, Barry R., additional, Moody, D. Branch, additional, Smale, Steven T., additional, Sagasti, Alvaro, additional, Modlin, Robert L., additional, and Ramakrishnan, Lalita, additional

Published
2017
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