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22 results on '"Cameron, Evan G."'

1. A molecular switch for neuroprotective astrocyte reactivity

Author

Cameron, Evan G., Nahmou, Michael, Toth, Anna B., Heo, Lyong, Tanasa, Bogdan, Dalal, Roopa, Yan, Wenjun, Nallagatla, Pratima, Xia, Xin, Hay, Sarah, Knasel, Cara, Stiles, Travis L., Douglas, Christopher, Atkins, Melissa, Sun, Catalina, Ashouri, Masoumeh, Bian, Minjuan, Chang, Kun-Che, Russano, Kristina, Shah, Sahil, Woodworth, Mollie B., Galvao, Joana, Nair, Ramesh V., Kapiloff, Michael S., and Goldberg, Jeffrey L.

Published
2024
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2. A molecular switch for neuroprotective astrocyte reactivity

Author

Cameron, Evan G., primary, Nahmou, Michael, additional, Toth, Anna B., additional, Heo, Lyong, additional, Tanasa, Bogdan, additional, Dalal, Roopa, additional, Yan, Wenjun, additional, Nallagatla, Pratima, additional, Xia, Xin, additional, Hay, Sarah, additional, Knasel, Cara, additional, Stiles, Travis L., additional, Douglas, Christopher, additional, Atkins, Melissa, additional, Sun, Catalina, additional, Ashouri, Masoumeh, additional, Bian, Minjuan, additional, Chang, Kun-Che, additional, Russano, Kristina, additional, Shah, Sahil, additional, Woodworth, Mollie B., additional, Galvao, Joana, additional, Nair, Ramesh V., additional, Kapiloff, Michael S., additional, and Goldberg, Jeffrey L., additional

Published
2023
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6. Shedding new light on opsin evolution

Author

Porter, Megan L., Blasic, Joseph R., Bok, Michael J., Cameron, Evan G., Pringle, Thomas, Cronin, Thomas W., and Robinson, Phyllis R.

Published
2012

7. Quantitative transportomics identifies Kif5a as a major regulator of neurodegeneration

Author

Shah, Sahil H, primary, Schiapparelli, Lucio M, primary, Ma, Yuanhui, additional, Yokota, Satoshi, additional, Atkins, Melissa, additional, Xia, Xin, additional, Cameron, Evan G, additional, Huang, Thanh, additional, Saturday, Sarah, additional, Sun, Catalina B, additional, Knasel, Cara, additional, Blackshaw, Seth, additional, Yates, John R, additional, Cline, Hollis T, additional, and Goldberg, Jeffrey L, additional

Published
2022
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8. Author response: Quantitative transportomics identifies Kif5a as a major regulator of neurodegeneration

Author

Shah, Sahil H, primary, Schiapparelli, Lucio M, primary, Ma, Yuanhui, additional, Yokota, Satoshi, additional, Atkins, Melissa, additional, Xia, Xin, additional, Cameron, Evan G, additional, Huang, Thanh, additional, Saturday, Sarah, additional, Sun, Catalina B, additional, Knasel, Cara, additional, Blackshaw, Seth, additional, Yates, John R, additional, Cline, Hollis T, additional, and Goldberg, Jeffrey L, additional

Published
2022
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9. MEF2 transcription factors differentially contribute to retinal ganglion cell loss after optic nerve injury

Author

Xia, Xin, primary, Yu, Caroline Y., additional, Bian, Minjuan, additional, Sun, Catalina B., additional, Tanasa, Bogdan, additional, Chang, Kun-Che, additional, Bruffett, Dawn M., additional, Thakur, Hrishikesh, additional, Shah, Sahil H., additional, Knasel, Cara, additional, Cameron, Evan G., additional, Kapiloff, Michael S., additional, and Goldberg, Jeffrey L., additional

Published
2020
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11. Opposing Effects of Growth and Differentiation Factors in Cell-Fate Specification

Author

Chang, Kun-Che, primary, Sun, Catalina, additional, Cameron, Evan G., additional, Madaan, Ankush, additional, Wu, Suqian, additional, Xia, Xin, additional, Zhang, Xiong, additional, Tenerelli, Kevin, additional, Nahmou, Michael, additional, Knasel, Cara M., additional, Russano, Kristina R., additional, Hertz, Jonathan, additional, and Goldberg, Jeffrey L., additional

Published
2019
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13. MOLECULAR DETERMINANTS OF MELANOPSIN SIGNALING AND DEACTIVATION

Author

Cameron, Evan G.

Subjects
Arrestin, genetic structures, Deactivation, sense organs, GPCR Signaling, Phosphorylation, Melanopsin, Calcium Imaging
Abstract

The unique visual pigment melanopsin is expressed in a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs) within the mammalian retina. The axons of ipRGCs primarily project to brain nuclei that regulate non-image forming visual functions including circadian photoentrainment, pupillary light reflex, and sleep. Unlike rods and cones which hyperpolarize in response to light, ipRGCs depolarize likely through the activation of a Gq-mediated phototransduction cascade. IpRGCs exhibit very poor temporal resolution with sluggish on/off kinetics and a high threshold of activation. Despite this, ipRGCs respond robustly to prolonged illumination and are capable of firing sustained action potentials beyond the lifetime of the stimulus. These response characteristics raise questions about how melanopsin signaling is regulated within the retina. Typically, visual pigment signaling is deactivated by receptor phosphorylation and arrestin binding which act to attenuate and inhibit G-protein binding, respectively. In this work, I investigate the role of arrestin in melanopsin signaling and identify a region within the C-terminal tail of melanopsin that is required for proper activation and deactivation. Using a combination of in vitro and in vivo approaches, I provide evidence for a light- and phosphorylation-dependent deactivation of melanopsin by Beta-arrestin. This work is the first description of a visual pigment deactivation mechanism mediated by Beta-arrestin and is consistent with canonical deactivation mechanism described for other non-visual G-protein coupled receptors (GPCRs). Additionally, I demonstrate that removal or mutation of a region within the proximal portion of melanopsin's C-tail delays the activation and deactivation of the photoresponse. I also show that this region is conserved within the melanopsin family implying important functional significance. Based on these results, I hypothesize that a 9th helix in the C-tail of melanopsin serves two purposes; 1) to stabilize ICL3 and form a portion of the G-protein binding domain and 2) to tether the C-tail close to the membrane surface, facilitating receptor phosphorylation and arrestin binding.

Published
2014
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14. Muscle A-Kinase Anchoring Protein-α is an Injury-Specific Signaling Scaffold Required for Neurotrophic- and Cyclic Adenosine Monophosphate-Mediated Survival

Author

Wang, Yan, primary, Cameron, Evan G., additional, Li, Jinliang, additional, Stiles, Travis L., additional, Kritzer, Michael D., additional, Lodhavia, Rahul, additional, Hertz, Jonathan, additional, Nguyen, Tu, additional, Kapiloff, Michael S., additional, and Goldberg, Jeffrey L., additional

Published
2015
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18. Shedding new light on opsin evolution

Author

Porter, Megan L., primary, Blasic, Joseph R., additional, Bok, Michael J., additional, Cameron, Evan G., additional, Pringle, Thomas, additional, Cronin, Thomas W., additional, and Robinson, Phyllis R., additional

Published
2011
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19. Characterization of visual pigments, oil droplets, lens and cornea in the whooping crane Grus americana.

Author

Porter, Megan L., Kingston, Alexandra C. N., McCready, Robert, Cameron, Evan G., Hofmann, Christopher M., Suarez, Lauren, Olsen, Glenn H., Cronin, Thomas W., and Robinson, Phyllis R.

Subjects
VISUAL pigments, WHOOPING crane, ULTRAVIOLET radiation, MICROSPECTROPHOTOMETRY, RETINAL rod photoreceptor cells, RETINAL cone photoreceptor cells
Abstract

Vision has been investigated in many species of birds, but few studies have considered the visual systems of large birds and the particular implications of large eyes and long-life spans on visual system capabilities. To address these issues we investigated the visual system of the whooping crane Grus americana (Gruiformes, Gruidae), which is one of only two North American crane species. It is a large, long-lived bird in which UV sensitivity might be reduced by chromatic aberration and entrance of UV radiation into the eye could be detrimental to retinal tissues. To investigate the whooping crane visual system we used microspectrophotometry to determine the absorbance spectra of retinal oil droplets and to investigate whether the ocular media (i.e. the lens and cornea) absorb UV radiation. In vitro expression and reconstitution was used to determine the absorbance spectra of rod and cone visual pigments. The rod visual pigments had wavelengths of peak absorbance (λmax) at 500 nm, whereas the cone visual pigment λmax values were determined to be 404 nm (SWS1 ), 450 nm (SWS2), 499 nm (RH2) and 561 nm (LWS), similar to other characterized bird visual pigment absorbance values. The oil droplet cut-off wavelength (λcut) values similarly fell within ranges recorded in other avian species: 576 nm (R-type), 522 nm (Y-type), 506 nm (P-type) and 448 nm (C-type). We confirm that G. americana has a violet-sensitive visual system; however, as a consequence of the αmax of the SWS1 visual pigment (404 nm), it might also have some UV sensitivity. [ABSTRACT FROM AUTHOR]

Published
2014
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20. Optic Nerve Crush in Mice to Study Retinal Ganglion Cell Survival and Regeneration.

Author

Cameron EG, Xia X, Galvao J, Ashouri M, Kapiloff MS, and Goldberg JL

Abstract

In diseases such as glaucoma, the failure of retinal ganglion cell (RGC) neurons to survive or regenerate their optic nerve axons underlies partial and, in some cases, complete vision loss. Optic nerve crush (ONC) serves as a useful model not only of traumatic optic neuropathy but also of glaucomatous injury, as it similarly induces RGC cell death and degeneration. Intravitreal injection of adeno-associated virus serotype 2 (AAV2) has been shown to specifically and efficiently transduce RGCs in vivo and has thus been proposed as an effective means of gene delivery for the treatment of glaucoma. Indeed, we and others routinely use AAV2 to study the mechanisms that promote neuroprotection and axon regeneration in RGCs following ONC. Herein, we describe a step-by-step protocol to assay RGC survival and regeneration in mice following AAV2-mediated transduction and ONC injury including 1) intravitreal injection of AAV2 viral vectors, 2) optic nerve crush, 3) cholera-toxin B (CTB) labeling of regenerating axons, 4) optic nerve clearing, 5) flat mount retina immunostaining, and 6) quantification of RGC survival and regeneration. In addition to providing all the materials and procedural details necessary to execute this protocol, we highlight its advantages over other similar published approaches and include useful tips to ensure its faithful reproduction in any modern laboratory., Competing Interests: Competing interests The authors declare no competing interests.

Published
2020
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22. NEUROREGENERATION. Promoting CNS repair.

Author

Cameron EG and Goldberg JL

Subjects
Animals, Immunomodulation, Nerve Growth Factors immunology, Nerve Growth Factors pharmacology, Neuroprotective Agents pharmacology, Retina physiology, Wound Healing immunology
Published
2016
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