1. Influence of selective laser sintering process parameters on microstructure and physicochemical properties of poly(vinyl alcohol) for the production of scaffolds
- Author
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Paulo Inforçatti, Thatyanne Gradowski, Camila Fernandes Higa, Selene Elifio-Esposito, Jorge Vicente Lopes da Silva, Marcelo Fernandes de Oliveira, Fred Lacerda Amorim, and Michelle S. Meruvia
- Subjects
chemistry.chemical_classification ,0209 industrial biotechnology ,Vinyl alcohol ,Materials science ,Mechanical Engineering ,Sintering ,02 engineering and technology ,Polymer ,021001 nanoscience & nanotechnology ,Microstructure ,Industrial and Manufacturing Engineering ,law.invention ,Selective laser sintering ,chemistry.chemical_compound ,Crystallinity ,020901 industrial engineering & automation ,chemistry ,Chemical engineering ,law ,Particle size ,Laser power scaling ,0210 nano-technology - Abstract
Purpose This study aims to investigate the production of scaffolds by selective laser sintering (SLS) using poly(vinyl alcohol) (PVA) polymer, for in vitro studies, a relatively new and growing area in which scaffolds could be used in the design of three-dimensional models for in vitro disease model or tissue equivalent for safety and effectiveness tests. Design/methodology/approach The influence of the SLS process parameters laser power, 26 W and 32 W, and number of laser scans, 1, 2, 4 and 6, on the surface microstructure of the samples and on the degree of crystallinity and chemical stability of PVA material, was investigated using powder with particle size of 20-320 µm. Laser sintered PVA samples were subjected to cell culture tests using osteoblastic cells derived from human osteosarcoma (SaOs-2). Findings The laser power has no significant influence on the microstructure of the laser-sintered samples, however the number of scans has a considerable influence on the sintering degree; the SLS process causes a decrease in the degree of crystallinity and changes the chemical structure of the as-received PVA, especially when using higher laser power and more number of scans. Preliminary in vitro cell culture tests show that the laser-sintered PVA material is biocompatible with SaOs-2 cells. Originality/value SLS offers good potential for the fabrication of scaffolds and thus, may be applied as an alternative to conventional scaffold fabrication processes to overcome their limitations.
- Published
- 2020
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