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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to present with pulmonary and extra-pulmonary organ complications. In comparison with the 2009 pandemic (pH1N1), SARS-CoV-2 infection is likely to lead to more severe disease, with multi-organ effects, including cardiovascular disease. SARS-CoV-2 has been associated with acute and long-term cardiovascular disease, but the molecular changes govern this remain unknown.In this study, we investigated the landscape of cardiac tissues collected at rapid autopsy from SARS-CoV-2, pH1N1, and control patients using targeted spatial transcriptomics approaches. Although SARS-CoV-2 was not detected in cardiac tissue, host transcriptomics showed upregulation of genes associated with DNA damage and repair, heat shock, and M1-like macrophage infiltration in the cardiac tissues of COVID-19 patients. The DNA damage present in the SARS-CoV-2 patient samples, were further confirmed by γ−H2Ax immunohistochemistry. In comparison, pH1N1 showed upregulation of Interferon-stimulated genes (ISGs), in particular interferon and complement pathways, when compared with COVID-19 patients.These data demonstrate the emergence of distinct transcriptomic profiles in cardiac tissues of SARS-CoV-2 and pH1N1 influenza infection supporting the need for a greater understanding of the effects on extra-pulmonary organs, including the cardiovascular system of COVID-19 patients, to delineate the immunopathobiology of SARS-CoV-2 infection, and long term impact on health.

Se supone que la cobertura de la vida cotidiana en la periferia brasilena puede adquirir una dimension que aun no ha sido explorada con el surgimiento de la pandemia Covid-19. Enfrentada concomitantemente ala polarizacion politica brasilena, la emergencia sanitaria permitio a la oposicion acunar la nocion de pandemonio como termino aplicable a las diferencias en la politica publica para combatir la pandemia. Lamaterializacion de la periferia metropolitana, tratada como el lugar simbolico de los mas pobres, esta ligada a las condiciones narrativas y discursivas establecidas por la orden de las noticias, encargadas deexpresar las condiciones de afrontamiento de los hechos. El analisis empirico de articulos periodisticos publicados online que exploran el (no) enfrentamiento de la pandemia en la periferia brasilena junto con el estudio de publicaciones en plataformas de redes sociales expone resultados que descalifican el imaginario de caos aplicable a las noticias de la periferia metropolitana en portadas de revistas del periodo de 1994 a 2014 para la situacion actual.Palabras clave: Periferia. Noticias. Pandemonio. Pandemia .Covid-19.

PT. Com a emergência da plataformização da atividade jornalística, busca-se investigar a relevância das capas na (re)constituição identitária do jornalismo. Desde a abordagem teórico-metodológica da semiótica material articulada aos estudos de plataformas, o objetivo deste texto é problematizar como a capa de jornal e de revista, considerada um elemento que foi fundamental para a atividade jornalística a contar de seu surgimento, passa a ser tratada com a convergência digital. Para tanto, são observadas transformações manifestas em capas jornalísticas. Trata-se de uma reflexão que requer situar as capas dentro de uma complexa rede de relações na qual se inscrevem questões como o propósito de sua produção atualmente, a queda na tiragem de veículos consagrados, a emergência de iniciativas jornalísticas inovadoras, o tensionamento entre a disposição material de capas em bancas, mercados ou na casa das pessoas e no meio digital e os recursos passíveis de se mobilizar em capas impressas e em capas veiculadas online. Reconfigurar suas capas no contexto de uma sociedade midiatizada representa um desafio grandioso às revistas e aos jornais tradicionais em todo o mundo. Observa-se que o valor das capas passa pelo percurso de migrar para as plataformas de mídia social com vistas a promover um determinado veículo. Elas manteriam, assim, seu valor tradicional de venda de um projeto editorial; agora, com o bônus de propagar-se rapidamente para muitas pessoas. O objeto empírico estudado, o projeto ACAPA, destaca-se pela produção de capas avulsas veiculadas exclusivamente em plataformas de mídia social. Como aponta a análise, suas criações subvertem a lógica da formatação consagrada de capas de revista e de jornal. Com recursos verbovisuais análogos, o ACAPA faz jornalismo de uma forma distinta do padrão dominante em capas, explicitando a mutação das modalidades de expressão editorial, e atinente ao contexto plataformizado de uma sociedade midiatizada. Um cenário em que a capa mantém seu potencial jornalístico e se reconfigura, midiatizando-se. *** EN. This paper will examine the relevance of front pages in (re)building journalism's identity in the context of the emergence of platform journalism. From a theoretical-methodological approach of articulated material semiotics to platform studies, our objective is to discuss how the front pages of newspapers and magazines, an essential feature of journalism, are being handled in a world of digital convergence. In order to accomplish this we observed the changes that have occurred to journalistic front pages over time. We looked at factors such as the objective of their current production; the drop in circulation of established media vehicles; the emergence of innovative journalistic initiatives; the tension between the material placement of front pages at newsstands, supermarkets or in people's homes; and the digital medium and the resources (e.g., graphics) that can be mobilized in printed and online front pages. Restructuring front pages in an online media-driven society is a major challenge for magazines and traditional newspapers around the world. Out of all the news products that must adapt to the communicational order of the new media, it is front pages that seem to have gone through a particularly substantial restructuring process. News-promotional pieces are considered editorial identity; they are a direct product of socio-cultural consumption. Front pages have to constantly include innovative elements in order to meet the (new) expectations of readers and, at the same time, keep up with changing social structures, especially in media. We have seen that the value of front pages nowadays has shifted to social media platforms and are used to promote a particular media vehicle. They therefore maintain their traditional selling value for an editorial project, with the added bonus of being quickly spread to many people. This paper's object of study, the ACAPA project, stands out for its production of front pages published exclusively for social media platforms. As our analysis demonstrates, this project’s creations represent a break from traditional forms of doing journalism and supplant the long-standing format of front pages for magazines and newspapers. It uses similar verbal and visual resources, but the ACAPA’s front pages are different from the standard as forms of editorial expression have changed due to the platform-based world of a media-driven society; a time during which front pages must maintain their journalistic relevance while being restructured to accommodate the new media. *** FR. Cet article examine la pertinence des Unes dans la (re)construction de l'identité du journalisme dans le contexte de l'émergence du journalisme de plateforme. D'une approche théorique-méthodologique de la sémiotique des matériaux articulés aux études de plates-formes, notre objectif est de discuter la manière dont les Unes des journaux et des magazines, une caractéristique essentielle du journalisme, sont traitées dans un monde de convergence numérique. Pour ce faire, nous avons observé les évolutions des Unes journalistiques. Nous avons examiné des facteurs tels que l'objectif de leur production actuelle, la baisse de la circulation des supports médiatiques établis, l'émergence d'initiatives journalistiques innovantes, la tension entre le placement matériel des Unes dans les kiosques à journaux, les supermarchés ou au domicile des gens, et le medium numérique et les ressources (par exemple, les graphiques) qui peuvent être mobilisées dans les Unes imprimées et en ligne. La restructuration des Unes dans une société dominée par les médias en ligne est un défi majeur pour les magazines et les journaux traditionnels dans le monde entier. Parmi tous les produits médiatique qui doivent s'adapter à l'ordre communicationnel des nouveaux médias, ce sont les Unes qui semblent avoir subi un processus de restructuration particulièrement important. Les articles promotionnels sont considérés comme une identité éditoriale ; ils sont un produit direct de la consommation socioculturelle. Les Unes doivent constamment inclure des éléments innovants afin de répondre aux (nouvelles) attentes des lecteurs et, en même temps, de suivre l'évolution des structures sociales, notamment dans les médias. Nous avons vu que la valeur des Unes s'est aujourd'hui déplacée vers les plateformes de médias sociaux et qu'elles sont utilisées pour promouvoir un support médiatique particulier. Elles conservent donc leur valeur de vente traditionnelle pour un projet éditorial, avec l'avantage supplémentaire d'être rapidement diffusées à un grand nombre de personnes. L'objet d'étude de ce document, le projet ACAPA, se distingue par sa production de premières pages publiées exclusivement pour les plateformes de médias sociaux. Comme le montre notre analyse, les créations de ce projet représentent une rupture par rapport aux formes traditionnelles de pratiques journalistiques et supplantent le format traditionnel des Unes de magazines et de journaux. Ce projet utilise des ressources textuelles et visuelles similaires, mais les Unes de l'ACAPA sont différentes des standards habituels dans la mesure où les formes d'expression éditoriale ont changé en raison de la prédominance des plates-formes dans une société dominée par les médias. Nous sommes ainsi encore dans une période pendant laquelle les Unes doivent conserver leur pertinence journalistique tout en étant restructurées pour s'adapter aux nouveaux médias. ***

The article analyses denunciations of media shielding operated by the alternative media with a view to the performance of the reference media. Paying attention to the context of digital convergence associated with political polarization, we study the crisis faced by journalistic mediation that allowed him to question his competence and communicational legitimacy. The analysis results from the composition of corpora formed by articles published between the years 2010 and 2015, election period and the governments of President Dilma Rousseff, by Brazilian electronic portals, websites and blogs. Among the results, there are procedures that recognize the use of shielding as an action of the reference media that acquires reverberation in the alternative media sphere when it lists complaints about the strategies used in situations recognized as shielding. His responsibility as an agent of socio-political polarization is unavoidable, given that he collaborated on laying the foundations for the practice of disseminating false news that had a wide impact on Brazil's 2018 presidential election.

Background An acute coronary syndrome (ACS) event can be linked to several risk factors, including kidney disease. Currently, it is unknown if kidney disease is associated with the in-hospital mortality of patients admitted with ACS, regardless of the main confounders. In this study, we aimed to determine if kidney disease predicts in-hospital mortality among ACS patients. Methodology This is a retrospective cohort study that included patients who were admitted to the cardiology center with ACS. The patients were analyzed for their clinical characteristics, previous diseases, risk factors, and blood samples for laboratory analysis. Continuous variables were analyzed using Student’s t-test, and categorical variables using the chi-square test. A p-value of

This article analyzes the journalistic discourses produced on the impeachment of President Dilma Rousseff on weekly magazine covers of national circulation within the context of mediatization of society. As empirical object of analysis, three covers were selected at the same date for each of the following magazines: CartaCapital, IstoE and Veja, ensuing the impeachment voting process in the Chamber of Deputies. The action of the weekly magazines on their elaborate covers during the political trial of Dilma Rousseff is subject of this article, considering the publishing commitment of these journalistic-promotional works.

El actual protagonismo de las personas naturales, inclusive en el derecho penal, se ha visto cuestionado por la paulatina relevancia económica y jurídica contemporánea de las personas jurídicas. De cara a este cambio de paradigma, este artículo académico estudia la controversia que produce la máxima societas delinquere non potest frente a la cada vez más notoria incorporación de un derecho penal expansivo, su vigencia y los intentos que han existido por derogarla en el ordenamiento jurídico na-cional. Para ello, estudia conceptos propios del derecho penal económico y luego brinda un recuento histórico acerca de la responsabilidad penal empresarial en el derecho colombiano. A continuación se ocupa de tres situaciones concretas en las que las personas jurídicas se relacionan con el derecho penal: i) la inhabilidad por extensión para contratar a la persona jurídica por delitos cometidos por sus directivos, ii) la suspensión y cancelación de la personería jurídica y iii) la vinculación como civilmente responsable en el incidente de reparación integral. Estos tres fenómenos son analizados en forma crítica desde los principios constitucionales que rigen el derecho penal. Finalmente, se pro-ponen algunas conclusiones, y en particular se afirma que la negativa a incorporar un régimen claro y coherente de responsabilidad para las personas jurídicas ha terminado por vincular estas, de facto, al derecho penal nacional.

No presente artigo analisamos os objetos empíricos selecionados para as investigações desenvolvidas na linha de pesquisa Mídias e Identidades Contemporâneas do Programa de PósGraduação em Comunicação da Universidade Federal de Santa Maria (UFSM). Consideramos como fonte de dados as dissertações e teses referentes à primeira década de produção efetiva do programa (2008-2017). O objetivo principal é identificar os objetos empíricos que foram submetidos ao exame científico e, como objetivo secundário, buscamos tecer alguns comentários e distinções acerca dos modos como os objetos do mundo – aquilo que se analisa – são estudados. Os resultados encontrados apontam para a predominância de pesquisas sobre a televisão (45,45%), seguida pelo jornal impresso (12,12%) e pela internet (10,60%).

O artigo analisa a produção científica da linha de pesquisa Mídias e Identidades Contemporâneas do Programa de Pós-Graduação em Comunicação (POSCOM) da Universidade Federal de Santa Maria (UFSM) durante a primeira década de publicações efetivas de dissertações de mestrado e teses de doutorado, entre 2008 e 2017. Foram analisados 66 trabalhos (56 dissertações e 10 teses) através do método pesquisa documental. Dentre os resultados, observou-se os principais autores utilizados (destacam-se Stuart Hall e Kathryn Woodward), o predomínio da abordagem qualitativa (87,88%), a presença do problema de pesquisa (80,30%) e do objetivo geral (100%). Verificou-se as abordagens metodológicas recorrentes (análise do discurso e semiótica, etnografia, análise cultural-midiática), a descrição dos procedimentos metodológicos (96,97%) e das técnicas de coletas de dados (92,43%).

Background: Myocardial injury is significantly and independently associated with mortality in COVID-19 patients. However, the pathogenesis of myocardial injury in COVID-19 is still not clear, and cardiac involvement by SARS-CoV-2 remains a major challenge worldwide.Aim: This histopathological and immunohistochemical study seeks to clarify the pathogenesis of myocardial injury in COVID-19.Methods: Postmortem minimally invasive autopsies were performed in two patients who died from COVID-19, and the myocardium samples were compared to a control patient. Immunohistochemistry (IHC) staining was performed using monoclonal antibodies against the following targets: caspase-1, ICAM-1, TNF-α, IL-4, IL-6, CD163, TGF-β, MMP-9, type 1 and type 3 collagen.Results: The histopathological analysis showed severe pericellular interstitial edema surrounding each of the cardiomyocytes. The IHC analysis showed increased expression of caspase-1, ICAM-1, IL-4, IL-6, CD163, MMP-9 and type 3 collagen in the COVID-19 patients compared to the control. On the other hand, no difference from the control was observed in expression of TNF-α, TGF-β and type 1 collagen. Conclusion: Our findings point to a pathogenesis related with pyroptosis leading to endothelial disfunction. The subsequent inflammation with associated interstitial edema could explain the myocardial disfunction and arrythmias in COVID-19 patients. The presence of Th2 response, MMP-9 and type-3 collagen suggests progression to myocardial fibrosis in the long term.

Background Ivabradine is currently indicated to lower heart rate in Heart Failure with Reduced Ejection Fraction (HFrEF) patients. However its effect apart from beta-blockers is not clear. Aim of the review To study the additional effect of ivabradine, apart from the effect of beta-blockers, on cardiovascular death, all-cause mortality, hospitalization due to HF and heart rate in HFrEF population. Method Electronic searches were conducted up to June 2016 to include randomized controlled trials where ivabradine was compared to a control group. Relative risks RRs and their 95% confidence intervals (CI 95%) were pooled and the random and fixed effect were used to summarize the results according to heterogeneity levels. Heterogeneity among studies was measured by the I-squared statistic Results Of 1790 studies, seven met the inclusion criteria for the systematic review and meta-analysis. The population consisted of 17,747 patients. Risk of bias was generally high for beta-blocker doses lower than recommended. Interventions lasted 1.5–22.9 months and pooled relative risks RR (95%) for all-cause mortality, cardiovascular death and hospitalization for HF were 0.98 (0.90–1.06); 0.99 (0.91–1.08); and 0.87 (0.68–1.12) respectively. Heart rate (CI 95%) decreased by 8.7 (6.37–11.03) beats per minute with ivabradine compared to the control group. Subgroup analysis by beta-blocker dose showed that for patients on recommended treatment (at least 50% of the beta-blocker target dose), heart rate (CI 95%) decreased by 4.70 (3.67–5.73), whereas for patients not on recommended treatment or with unreported dose, heart rate decreased by 8.60 (8.13–9.08). Conclusion Ivabradine significantly reduced heart rate and its additional effect on heart rate appears to be inversely correlated with the dose of beta-blocker. It showed no significant effect for all-cause mortality, cardiovascular death and hospitalization due to HF. Unreported beta-blocker doses and beta-blocker doses lower than recommended limited the conclusions.

O projeto de ensino “Internato Extracurricular em Obstetrícia na Maternidade do Hospital Escola UFPEL” foi desenvolvido com o objetivo de inserir os estudantes já no início de sua graduação em um ambiente hospitalar. O projeto extracurricular ocorre no Hospital Escola da UFPel, e os estudantes vivenciam as rotinas práticas de uma maternidade com portas abertas 24horas, elucidando e ilustrando os conteúdos teóricos apresentados nas disciplinas curriculares do curso de medicina da UFPEL. Assim, o aluno aprende a prática da Ginecologia e Obstetrícia de maneira segura e produtiva junto aos professores e aos profissionais em formação da área.